MCID: CTN013
MIFTS: 37

Cutaneous Anthrax

Categories: Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Cutaneous Anthrax

MalaCards integrated aliases for Cutaneous Anthrax:

Name: Cutaneous Anthrax 12 74 52 43 15 71 32
Anthrax, Skin Type 52
Skin Anthrax 52

Classifications:



External Ids:

Disease Ontology 12 DOID:7426
ICD9CM 34 022.0
MeSH 43 C531621
SNOMED-CT 67 84980006
ICD10 32 A22.0
UMLS 71 C0003177

Summaries for Cutaneous Anthrax

Disease Ontology : 12 An anthrax disease that results in infection located in skin, has material basis in Bacillus anthracis, which is transmitted by contact with infected animals or animal products. The infection has symptom skin lesion that eventually forms an ulcer with a black center.

MalaCards based summary : Cutaneous Anthrax, also known as anthrax, skin type, is related to anthrax disease and gastrointestinal anthrax, and has symptoms including skin lesion An important gene associated with Cutaneous Anthrax is PON1 (Paraoxonase 1), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Uptake and actions of bacterial toxins. The drugs Aluminum hydroxide and Antacids have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related phenotype is mortality/aging.

Wikipedia : 74 Anthrax is an infection caused by the bacterium Bacillus anthracis. It can occur in four forms: skin,... more...

Related Diseases for Cutaneous Anthrax

Graphical network of the top 20 diseases related to Cutaneous Anthrax:



Diseases related to Cutaneous Anthrax

Symptoms & Phenotypes for Cutaneous Anthrax

Symptoms:

12
  • skin lesion

MGI Mouse Phenotypes related to Cutaneous Anthrax:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.32 ADA ADCY7 ANTXR1 ANTXR2 FURIN MAP2K3

Drugs & Therapeutics for Cutaneous Anthrax

Drugs for Cutaneous Anthrax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
2 Antacids Phase 2
3 Adjuvants, Immunologic Phase 2
4 Anti-Ulcer Agents Phase 2
5 Gastrointestinal Agents Phase 2
6 Immunologic Factors Phase 2
7 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-Blind, Parallel-Group Study of the Safety, Tolerability and Immunogenicity of a Range of Doses and Dosing Schedules of Recombinant (rPA Based) Anthrax Vaccine in Healthy Subjects Completed NCT00170456 Phase 2
2 A Phase II, Dose Ranging Multi-Centre, Single Blind, Parallel-Group, Controlled Study of the Safety, Tolerability and Immunogenicity of Recombinant (rPA Based) Anthrax Vaccine Compared With Anthrax Vaccine Adsorbed in a Healthy Population Completed NCT00170469 Phase 2
3 Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated Recipients Recruiting NCT00050310

Search NIH Clinical Center for Cutaneous Anthrax

Cochrane evidence based reviews: cutaneous anthrax

Genetic Tests for Cutaneous Anthrax

Anatomical Context for Cutaneous Anthrax

The Foundational Model of Anatomy Ontology organs/tissues related to Cutaneous Anthrax:

19
Skin

MalaCards organs/tissues related to Cutaneous Anthrax:

40
Skin, Lung, T Cells, Eye, Lymph Node, Brain, Liver

Publications for Cutaneous Anthrax

Articles related to Cutaneous Anthrax:

(show top 50) (show all 318)
# Title Authors PMID Year
1
Human anthrax in Kyrgyz Republic: Epidemiology and clinical features. 61
32276875 2020
2
Epidemiological and comparative genomic analysis of Bacillus anthracis isolated from northern Vietnam. 61
32084143 2020
3
Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes. 61
32294093 2020
4
Epidemiological Investigation and Etiological Analysis of a Cutaneous Anthrax Epidemic Caused by Butchering Sick Cattle in Guizhou, China. 61
32269982 2020
5
Sporadic human cutaneous anthrax outbreak in Shaanxi Province, China: report of two cases from 2018. 61
31926898 2020
6
Human Orf: An Under-recognized Entity. 61
31969245 2019
7
Bacillus cereus-Attributable Primary Cutaneous Anthrax-Like Infection in Newborn Infants, India. 61
31211665 2019
8
Unexpected human cases of cutaneous anthrax in Latium region, Italy, August 2017: integrated human-animal investigation of epidemiological, clinical, microbiological and ecological factors. 61
31213220 2019
9
Cutaneous Anthrax Outbreak in the Trakya Region of Turkey 61
30701847 2019
10
A cutaneous Anthrax outbreak in Koraput District of Odisha-India 2015. 61
32326927 2019
11
Development and Performance of a Checklist for Initial Triage After an Anthrax Mass Exposure Event. 61
30884525 2019
12
Gastrointestinal and cutaneous anthrax: Case series. 61
31073544 2019
13
Suspected cutaneous anthrax in rural areas. 61
32036346 2019
14
Surgical Treatment of Cutaneous Anthrax. 61
31859939 2019
15
An ELISA using a recombinant chimera of protective antigen and lethal factor for serodiagnosis of cutaneous anthrax in India. 61
30635155 2019
16
Risk factors for human cutaneous anthrax outbreaks in the hotspot districts of Northern Tanzania: an unmatched case-control study. 61
30839712 2018
17
[Cutaneous anthrax, the last outbreak diagnosed in Chile]. 61
29912259 2018
18
Two cases of human cutaneous anthrax with massive tissue damage, severe edema, and slight injury to the liver. 61
29231245 2018
19
Exaggerated Arthropod Bite: A Case Report and Review of the Mimics. 61
29849262 2018
20
Rates and risk factors for human cutaneous anthrax in the country of Georgia: National surveillance data, 2008-2015. 61
29415029 2018
21
Correction: Rates and risk factors for human cutaneous anthrax in the country of Georgia: National surveillance data, 2008-2015. 61
29718987 2018
22
Investigation and source-tracing of an anthrax outbreak in Gansu Province, China. 61
30161194 2018
23
Diagnosis of cutaneous anthrax in resource-poor settings in West Arsi Province, Ethiopia. 61
29284252 2017
24
A serious case of anthrax associated with compartment syndrome. 61
28076996 2017
25
[Epidemiological characteristics of a cutaneous anthrax outbreak in Huairou District of Beijing]. 61
29136755 2017
26
Evaluation of clinical and serological findings for diagnosis of cutaneous anthrax infection after an outbreak. 61
28076993 2017
27
Anthrax: Where Margins are Merging between Emerging Threats and Bioterrorism. 61
28979006 2017
28
Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax. 61
27461010 2017
29
Cutaneous Anthrax. 61
27742398 2017
30
Genetic source tracking of an anthrax outbreak in Shaanxi province, China. 61
28093076 2017
31
Immune-modulating Activity of Hydrogel Microparticles Contributes to the Host Defense in a Murine Model of Cutaneous Anthrax. 61
28894739 2017
32
Evaluation of cutaneous anthrax cases during an outbreak in the east region of Turkey. 61
27966316 2016
33
A single black ulcer in a child with acute lymphocytic leukemia. 61
28099607 2016
34
Source and risk factors of a cutaneous anthrax outbreak, Jiangsu, Eastern China, 2012. 61
27277672 2016
35
Cutaneous anthrax: evaluation of 28 cases in the Eastern Anatolian region of Turkey. 61
26293781 2016
36
A retrospective chart review study to describe selected zoonotic and arboviral etiologies in hospitalized febrile patients in the Republic of Armenia. 61
27553785 2016
37
An outbreak of cutaneous anthrax in Yunnan, China. 61
27329849 2016
38
Cutaneous Anthrax on Eyelid in a Pregnant Woman. 61
27551179 2016
39
Childhood-onset eosinophilic granulomatosis with polyangiitis: a rare childhood vasculitis mimicking anthrax and eosinophilic leukaemia. 61
26887883 2016
40
Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child. 61
26868410 2016
41
Human Cutaneous Anthrax, the East Anatolian Region of Turkey 2008-2014. 61
26720232 2016
42
Mapping as a tool for predicting the risk of anthrax outbreaks in Northern Region of Ghana. 61
28149439 2016
43
Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015. 61
27299730 2016
44
A Comparison of the Adaptive Immune Response between Recovered Anthrax Patients and Individuals Receiving Three Different Anthrax Vaccines. 61
27007118 2016
45
Cutaneous anthrax in an unusual location: case report. 61
26700091 2015
46
A case of cutaneous anthrax presenting with classical lesions. 61
26340973 2015
47
Periorbital cellulitis due to cutaneous anthrax. 61
25763844 2015
48
Genome Sequence of Bacillus anthracis Larissa, Associated with a Case of Cutaneous Anthrax in Greece. 61
26564034 2015
49
Antimicrobial Treatment for Systemic Anthrax: Analysis of Cases from 1945 to 2014 Identified Through a Systematic Literature Review. 61
26623698 2015
50
Development & validation of a quantitative anti-protective antigen IgG enzyme linked immunosorbent assay for serodiagnosis of cutaneous anthrax. 61
26354217 2015

Variations for Cutaneous Anthrax

Expression for Cutaneous Anthrax

Search GEO for disease gene expression data for Cutaneous Anthrax.

Pathways for Cutaneous Anthrax

GO Terms for Cutaneous Anthrax

Biological processes related to Cutaneous Anthrax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of adenylate cyclase activity GO:0007190 9.43 ADCY7 ADCY2
2 toxin transport GO:1901998 9.4 ANTXR2 ANTXR1
3 renal water homeostasis GO:0003091 9.37 ADCY7 ADCY2
4 cellular response to glucagon stimulus GO:0071377 9.32 ADCY7 ADCY2
5 activation of protein kinase A activity GO:0034199 9.26 ADCY7 ADCY2
6 cyclic nucleotide biosynthetic process GO:0009190 9.16 ADCY7 ADCY2
7 reproductive process GO:0022414 8.96 ANTXR2 ANTXR1
8 cAMP biosynthetic process GO:0006171 8.62 ADCY7 ADCY2

Molecular functions related to Cutaneous Anthrax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.73 PPIP5K2 MKKS MAP2K3 KIF1C ADCY7 ADCY2
2 nucleotide binding GO:0000166 9.5 PPIP5K2 MTG1 MKKS MAP2K3 KIF1C ADCY7
3 phosphorus-oxygen lyase activity GO:0016849 9.16 ADCY7 ADCY2
4 adenylate cyclase activity GO:0004016 8.62 ADCY7 ADCY2

Sources for Cutaneous Anthrax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....