MCID: CTN033
MIFTS: 38

Cutaneous Candidiasis

Categories: Infectious diseases, Skin diseases
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Aliases & Classifications for Cutaneous Candidiasis

MalaCards integrated aliases for Cutaneous Candidiasis:

Name: Cutaneous Candidiasis 11 14 71
Candidiasis, Cutaneous 43

Classifications:



External Ids:

Disease Ontology 11 DOID:0080161
MeSH 43 D002179
UMLS 71 C0006846

Summaries for Cutaneous Candidiasis

Disease Ontology: 11 A candidiasis that is characterized by Candida infection located in the skin.

MalaCards based summary: Cutaneous Candidiasis, also known as candidiasis, cutaneous, is related to candidiasis and vaginitis. An important gene associated with Cutaneous Candidiasis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and placenta, and related phenotypes are Increased shRNA abundance (Z-score > 2) and immune system

Related Diseases for Cutaneous Candidiasis

Diseases related to Cutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 candidiasis 30.6 IL17RC IL17RA IL17F IL17A CLEC7A CARD9
2 vaginitis 30.3 IL17A CCR6
3 psoriasis 1 30.2 IL17A CCR6
4 folliculitis 30.1 IL17RA IL17A CCR6
5 tinea cruris 30.0 CLEC6A CARD9
6 psoriasis 11 29.9 IL17RA IL17F IL17A
7 pernicious anemia 29.8 NUDT10 CCR6 AIRE
8 autoimmune disease 29.8 IL17F IL17A CCR6 AIRE
9 tinea corporis 29.7 CLEC7A CLEC6A CARD9
10 skin disease 29.7 IL17RA IL17F IL17A CCR6 AIRE
11 pustulosis of palm and sole 29.6 IL17F IL17C IL17A CCR6
12 cryptococcosis 29.3 IL17A CLEC7A CLEC6A CCR6 CARD9
13 vulvovaginal candidiasis 29.1 IL17RA IL17A CLEC7A CLEC6A CCR6 CARD9
14 dermatophytosis 29.0 IL17F IL17A IL12RB1 CLEC7A CLEC6A CCR6
15 tinea pedis 28.8 ZNF347 IL17A CLEC7A CLEC6A CCR6 CARD9
16 fungal infectious disease 28.1 IL17RC IL17RA IL17F IL17A IL12RB1 CLEC7A
17 oral candidiasis 28.1 IL17RC IL17RA IL17F IL17A IL12RB1 CLEC7A
18 hyper ige syndrome 28.1 IL17RC IL17RA IL17F IL17A IL12RB1 CLEC7A
19 chronic mucocutaneous candidiasis 27.2 NUDT10 IL17RE IL17RC IL17RA IL17F IL17C
20 exanthem 10.3
21 immunodeficiency 11 10.3 CCR6 CARD9
22 skin sarcoidosis 10.3 IL17A CCR6
23 sapho syndrome 10.3 IL17A CCR6
24 autoimmune cholangitis 10.3 IL17A CCR6
25 aortitis 10.3 IL17A CCR6
26 enthesopathy 10.3 IL17A CCR6
27 sympathetic ophthalmia 10.3 IL17A CCR6
28 scleral disease 10.3 IL17A CCR6
29 acute generalized exanthematous pustulosis 10.3 IL17F IL17A
30 angular cheilitis 10.3 IL17A AIRE
31 progressive relapsing multiple sclerosis 10.3 IL17A CCR6
32 dacryoadenitis 10.2 IL17A CCR6
33 iritis 10.2 IL17A CCR6
34 crohn's colitis 10.2 IL17A CCR6
35 autoimmune vasculitis 10.2 IL17A CCR6
36 autoimmune glomerulonephritis 10.2 IL17A CCR6
37 inflammatory bowel disease 18 10.2 IL17A CCR6
38 trichosporonosis 10.2 CLEC7A CARD9
39 intermediate uveitis 10.2 IL17A CCR6
40 choroiditis 10.2 IL17A CCR6
41 chorioretinitis 10.2 IL17A CCR6
42 chronic conjunctivitis 10.2 IL17A CCR6
43 birdshot chorioretinopathy 10.2 IL17A CCR6
44 seborrheic dermatitis 10.2 IL17A CCR6
45 meningovascular neurosyphilis 10.2 IL17RA IL17A
46 tularemia 10.2 IL17A CCR6
47 crescentic glomerulonephritis 10.2 IL17A CCR6
48 acute asthma 10.2 IL17A CCR6
49 central nervous system vasculitis 10.2 IL17A CCR6
50 acute proliferative glomerulonephritis 10.2 IL17A CCR6

Graphical network of the top 20 diseases related to Cutaneous Candidiasis:



Diseases related to Cutaneous Candidiasis

Symptoms & Phenotypes for Cutaneous Candidiasis

GenomeRNAi Phenotypes related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

25 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.53 IL17RC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 IL17RC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.53 IL17RC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.53 IL17A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.53 IL17RC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.53 IL17C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.53 IL17C IL17RC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.53 IL17A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.53 IL17C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.53 IL17RC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.53 IL17RC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.53 IL17RC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.53 IL17A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.53 IL17A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.53 IL17C

MGI Mouse Phenotypes related to Cutaneous Candidiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.77 AIRE CARD9 CCR6 CLEC6A CLEC7A IL12RB1
2 digestive/alimentary MP:0005381 9.63 AIRE CLEC7A IL17A IL17C IL17F IL17RE
3 hematopoietic system MP:0005397 9.36 AIRE CARD9 CCR6 CLEC6A CLEC7A IL12RB1

Drugs & Therapeutics for Cutaneous Candidiasis

Drugs for Cutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
3 Hormones Phase 4
4 Anti-Infective Agents Phase 4
5 Antifungal Agents Phase 4
6 Hormone Antagonists Phase 4
7 Anti-Infective Agents, Local Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Cytochrome P-450 CYP3A Inhibitors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective 2-Year Longitudinal Study to Assess for Miconazole Resistance in Candida Spp. With Repeated Treatment Courses of 0.25% Miconazole Nitrate Ointment in Neonates and Infants up to 1 Year of Age With Recurrent Moderate-Severe Diaper Dermatitis Complicated by Cutaneous Candidiasis Completed NCT00702507 Phase 4 0.25 % Miconazole Nitrate Ointment

Search NIH Clinical Center for Cutaneous Candidiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ciclopirox
Ciclopirox olamine
Clotrimazole
Econazole
Econazole Nitrate
Gentian Violet
Ketoconazole
Miconazole
Miconazole Nitrate
MICONAZOLE NITRATE PWDR
NYSTATIN PWDR
oxiconazole
sulconazole
Sulconazole nitrate

Cochrane evidence based reviews: candidiasis, cutaneous

Genetic Tests for Cutaneous Candidiasis

Anatomical Context for Cutaneous Candidiasis

Organs/tissues related to Cutaneous Candidiasis:

FMA: Skin
MalaCards : Skin, Liver, Placenta, Neutrophil

Publications for Cutaneous Candidiasis

Articles related to Cutaneous Candidiasis:

(show top 50) (show all 324)
# Title Authors PMID Year
1
Congenital cutaneous candidiasis in a full-term neonate. 62
35879203 2022
2
Congenital cutaneous candidiasis in one infant among a twin sibling pair. 62
34045281 2022
3
Synergistic Effect of the Combination of Deferoxamine and Fluconazole In Vitro and In Vivo against Fluconazole-Resistant Candida Spp. 62
36286552 2022
4
Hexyl-Aminolevulinate Ethosomes: a Novel Antibiofilm Agent Targeting Zinc Homeostasis in Candida albicans. 62
36301105 2022
5
Statement of retraction: Influence of various lipid core on characteristics of SLNs designed for topical delivery of fluconazole against cutaneous candidiasis. 62
36281888 2022
6
A pregnant woman with thymoma-associated pure red cell aplasia. 62
36303124 2022
7
Deep cutaneous candidiasis of the lip in a patient with acute myelogenous leukemia. 62
35996445 2022
8
Outbreak of canine distemper and coinfections in a maned wolf (Chrysocyon brachyurus) and in three giant anteaters (Myrmecophaga tridactyla). 62
35864379 2022
9
Microbiological and molecular screening of Candida spp. isolated from genital tract of asymptomatic pregnant women. 62
36126092 2022
10
An atypical case of cutaneous candidiasis caused by a face mask: With useful dermoscopic findings. 62
36093758 2022
11
Developing a new treatment for superficial fungal infection using antifungal Collagen-HSAF dressing. 62
36176602 2022
12
Congenital cutaneous candidiasis in a premature neonate: A case report. 62
35592050 2022
13
Mucocutaneous and cutaneous generalized candidiasis in a thymectomized dog. 62
35106278 2022
14
Risk of candidiasis associated with interleukin-17 inhibitors: A real-world observational study of multiple independent sources. 62
34950923 2022
15
Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years. 62
35992679 2022
16
In-vitro and in-vivo anticandidal activity of Trachyspermum ammi (L.) sprague seeds ethanolic extract and thymol-containing hexanes fraction. 62
32233667 2021
17
A Hematologic Disease Disguised as Cutaneous Candidiasis. 62
34956779 2021
18
Silver chitosan nanocomposites as a potential treatment for superficial candidiasis. 62
34036352 2021
19
Development of a Topical Amphotericin B and Bursera graveolens Essential Oil-Loaded Gel for the Treatment of Dermal Candidiasis. 62
34681257 2021
20
Two cases of primary cutaneous candidiasis caused by Candida parapsilosis: a report and literature review. 62
34147759 2021
21
A rare case report: Cutaneous Candida tropicalis infection disguised as a sacral decubitus rash in an immunocompetent individual. 62
34153726 2021
22
Congenital Cutaneous Candidiasis With Systemic Dissemination in a Preterm Infant. 62
33538540 2021
23
Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis. 62
33741400 2021
24
Evaluation of the effect of the gold nanoparticles prepared by green ‎chemistry on ‎the ‏treatment of cutaneous candidiasis. 62
34553090 2021
25
Exploiting solid lipid nanoparticles and nanostructured lipid carriers for drug delivery against cutaneous fungal infections. 62
33156736 2021
26
Cutaneous candidiasis caused by Candida kefyr. 62
33995784 2021
27
Oleic Acid Vesicles as a new Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar rats. 62
33176662 2020
28
Utilization of an in vitro biofabricated 3D skin as a pathological model of cutaneous candidiasis. 62
33021319 2020
29
In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis. 62
32429646 2020
30
Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis. 62
32649991 2020
31
Quinine Improves the Fungicidal Effects of Antimicrobial Blue Light: Implications for the Treatment of Cutaneous Candidiasis. 62
31746024 2020
32
Case of acne-like lesion of cutaneous candidiasis in a healthy man. 62
32147819 2020
33
A case of cutaneous candidiasis of upper eyelid in association with facial paralysis. 62
32174586 2020
34
Congenital cutaneous candidiasis associated with maternal peripartum candidemia. 62
32493666 2020
35
Chronic cutaneous candidiasis in children: should we stop there? Report of two cases associated with auto-immune polyendocrinopathy syndrome type I. 62
32188450 2020
36
A case of Jarisch-Herxheimer reaction in candidiasis treated with systemic fluconazole. 62
32020750 2020
37
Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant Candida albicans in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment. 62
32983038 2020
38
Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. 62
31287594 2019
39
Itraconazole lipid nanocapsules gel for dermatological applications: In vitro characteristics and treatment of induced cutaneous candidiasis. 62
31202972 2019
40
Cutaneous candidiasis in Tehran-Iran: from epidemiology to multilocus sequence types, virulence factors and antifungal susceptibility of etiologic Candida species. 62
31719957 2019
41
Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis. 62
30171656 2019
42
Impact of Process Parameters on Particle Size Involved in Media Milling Technique Used for Preparing Clotrimazole Nanocrystals for the Management of Cutaneous Candidiasis. 62
31028492 2019
43
Severe Cutaneous Candidiasis in a Liver Transplant Patient. 62
30891169 2019
44
Autoimmune polyglandular syndrome type 1: a case report and brief review. 62
31258868 2019
45
Management of congenital cutaneous candidiasis in a healthy term baby: A case report. 62
31588361 2019
46
Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets. 62
29447400 2018
47
Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity. 62
29873597 2018
48
Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. 62
29164434 2018
49
Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment. 62
30101725 2018
50
Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation. 62
29882446 2018

Variations for Cutaneous Candidiasis

Expression for Cutaneous Candidiasis

Search GEO for disease gene expression data for Cutaneous Candidiasis.

Pathways for Cutaneous Candidiasis

Pathways related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 IL17RE IL17RC IL17RA IL17F IL17C IL17A
2
Show member pathways
13.36 IL17RC IL17RA IL17F IL17C IL17A IL12RB1
3
Show member pathways
13.06 IL17RE IL17RC IL17RA IL17F IL17C IL17A
4
Show member pathways
11.72 IL17RE IL17RC IL17RA IL17F IL17C IL17A
5
Show member pathways
11.67 IL17F IL17A IL12RB1
6
Show member pathways
11.63 IL12RB1 IL17A IL17F IL17RA
7 11.56 IL17A IL12RB1 CCR6
8
Show member pathways
11.52 IL17RC IL17RA IL17F IL17A IL12RB1
9
Show member pathways
11.32 IL17F IL17C IL17A
10
Show member pathways
11.28 IL17RE IL17RC IL17RA IL17F IL17C IL17A
11 11.01 IL17F IL17C IL17A
12 10.97 IL17F IL17A
13 10.13 IL17RC IL17RA IL17A

GO Terms for Cutaneous Candidiasis

Biological processes related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.25 CARD9 CLEC6A CLEC7A IL17A IL17F IL17RA
2 inflammatory response GO:0006954 10.21 IL17RE IL17RC IL17RA IL17F IL17C IL17A
3 adaptive immune response GO:0002250 10.19 IL17RA IL17F IL17A CLEC6A CARD9
4 positive regulation of tumor necrosis factor production GO:0032760 10.08 IL17A CLEC7A CARD9
5 positive regulation of cytokine production GO:0001819 10.05 IL17F CLEC6A CARD9
6 immune system process GO:0002376 10 IL17RA IL17F IL17A CLEC7A CLEC6A CARD9
7 antifungal innate immune response GO:0061760 9.93 CLEC7A CLEC6A CARD9
8 defense response to fungus GO:0050832 9.92 IL17RC IL17RA IL17A CLEC6A
9 interleukin-17-mediated signaling pathway GO:0097400 9.91 IL17A IL17F IL17RA
10 positive regulation of interleukin-23 production GO:0032747 9.88 IL17RA IL17A CLEC7A
11 response to yeast GO:0001878 9.87 CLEC7A CLEC6A
12 granulocyte chemotaxis GO:0071621 9.86 IL17RC IL17RA
13 fibroblast activation GO:0072537 9.84 IL17RA IL17A
14 regulation of interleukin-2 production GO:0032663 9.81 IL17F CARD9
15 positive regulation of antimicrobial peptide production GO:0002225 9.8 IL17F IL17A
16 detection of yeast GO:0001879 9.78 CLEC7A CLEC6A
17 regulation of interleukin-6 production GO:0032675 9.77 IL17F CARD9
18 positive regulation of T-helper 17 type immune response GO:2000318 9.76 IL12RB1 CLEC7A CLEC6A CARD9
19 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.73 IL17A IL17F IL17RA
20 positive regulation of interleukin-6 production GO:0032755 9.73 IL17RC IL17RA IL17F IL17A CLEC7A CARD9
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.4 IL17RC IL17RA IL17F IL17A CLEC7A CARD9

Molecular functions related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-17 receptor activity GO:0030368 9.1 IL17RE IL17RC IL17RA

Sources for Cutaneous Candidiasis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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