MCID: CTN033
MIFTS: 38

Cutaneous Candidiasis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Cutaneous Candidiasis

MalaCards integrated aliases for Cutaneous Candidiasis:

Name: Cutaneous Candidiasis 12 15 70
Candidiasis, Cutaneous 44

Classifications:



External Ids:

Disease Ontology 12 DOID:0080161
MeSH 44 D002179
UMLS 70 C0006846

Summaries for Cutaneous Candidiasis

Disease Ontology : 12 A candidiasis that is characterized by Candida infection located in the skin.

MalaCards based summary : Cutaneous Candidiasis, also known as candidiasis, cutaneous, is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and candidiasis. An important gene associated with Cutaneous Candidiasis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, placenta and neutrophil, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Cutaneous Candidiasis

Diseases related to Cutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.2 IL17A AIRE
2 candidiasis 30.1 IL17RC IL17RA IL17F IL17A CLEC7A CARD9
3 pustulosis of palm and sole 30.0 IL17A CCR6
4 pernicious anemia 29.9 CCR6 AIRE
5 candidiasis, familial, 2 29.9 CLEC7A CARD9
6 bacterial infectious disease 29.8 TLR3 IL17A CCR6
7 tinea cruris 29.7 CLEC6A CARD9
8 neonatal candidiasis 29.6 CLEC7A CLEC6A CARD9
9 autoimmune disease 29.3 IL2RA IL17F IL17A CCR6 AIRE
10 tinea pedis 29.3 CLEC7A CLEC6A CARD9
11 tinea corporis 29.3 CLEC7A CLEC6A CARD9
12 hyper ige syndrome 29.1 TLR3 IL17RA IL17F IL17A CCR6 CARD9
13 dermatophytosis 29.0 IL17A CLEC7A CLEC6A CCR6 CARD9
14 cryptococcosis 28.7 IL17A CLEC7A CLEC6A CCR6 CARD9
15 oral candidiasis 28.6 IL17RA IL17A CLEC7A CLEC6A CCR6 CARD9
16 fungal infectious disease 27.9 IL17RC IL17RA IL17F IL17A CLEC7A CLEC6A
17 chronic mucocutaneous candidiasis 27.3 IL2RA IL17RE IL17RC IL17RA IL17F IL17A
18 bell's palsy 10.3 TLR3 IL2RA
19 vernal conjunctivitis 10.3 IL2RA CCR6
20 exanthem 10.3
21 autoimmune polyendocrine syndrome, type ii 10.3 CCR6 AIRE
22 tuberculoid leprosy 10.3 IL2RA CCR6
23 retinal vasculitis 10.3 TLR3 CCR6
24 anogenital venereal wart 10.2 TLR3 CCR6
25 t-cell adult acute lymphocytic leukemia 10.2 IL2RA CCR6
26 immunodeficiency 31c 10.2 IL2RA AIRE
27 immunodeficiency 29 10.2 IL17RC CARD9
28 autoimmune enteropathy 10.2 IL2RA IL17A
29 nail disorder, nonsyndromic congenital, 1 10.2 CCR6 AIRE
30 pneumonic tularemia 10.2 IL17A CCR6
31 adrenal cortical hypofunction 10.2 CCR6 AIRE
32 tularemia 10.2 IL17A CCR6
33 systemic autoimmune disease 10.2 IL17A AIRE
34 scleral disease 10.2 IL17A CCR6
35 dacryoadenitis 10.2 IL17A CCR6
36 iritis 10.2 IL17A CCR6
37 inflammatory bowel disease 18 10.2 IL17A CCR6
38 meningovascular neurosyphilis 10.2 IL17RA IL17A
39 autoimmune cholangitis 10.2 IL17A CCR6
40 intermediate uveitis 10.2 IL2RA CCR6
41 fungal meningitis 10.2 IL17A CCR6
42 acute generalized exanthematous pustulosis 10.2 IL17F IL17A
43 central nervous system vasculitis 10.2 IL17A CCR6
44 acute proliferative glomerulonephritis 10.2 IL17A CCR6
45 vulvovaginitis 10.2
46 nasopharyngitis 10.2 IL17A CCR6
47 autoimmune disease of urogenital tract 10.2 IL17A CCR6
48 nickel allergic contact dermatitis 10.2 IL17F IL17A
49 intestinal schistosomiasis 10.1 IL17A CCR6
50 psoriasis 15 10.1 IL17F IL17A

Graphical network of the top 20 diseases related to Cutaneous Candidiasis:



Diseases related to Cutaneous Candidiasis

Symptoms & Phenotypes for Cutaneous Candidiasis

MGI Mouse Phenotypes related to Cutaneous Candidiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 AIRE CARD9 CCR6 CLEC6A CLEC7A IL17A
2 digestive/alimentary MP:0005381 9.73 AIRE CLEC7A IL17A IL17F IL17RE IL2RA
3 immune system MP:0005387 9.73 AIRE CARD9 CCR6 CLEC6A CLEC7A IL17A
4 respiratory system MP:0005388 9.17 AIRE CLEC7A IL17A IL17F IL17RA IL2RA

Drugs & Therapeutics for Cutaneous Candidiasis

Drugs for Cutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3 Cytochrome P-450 CYP3A Inhibitors Phase 4
4 Anti-Infective Agents, Local Phase 4
5 Hormones Phase 4
6 Hormone Antagonists Phase 4
7 Antifungal Agents Phase 4
8 Anti-Infective Agents Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective 2-Year Longitudinal Study to Assess for Miconazole Resistance in Candida Spp. With Repeated Treatment Courses of 0.25% Miconazole Nitrate Ointment in Neonates and Infants up to 1 Year of Age With Recurrent Moderate-Severe Diaper Dermatitis Complicated by Cutaneous Candidiasis Completed NCT00702507 Phase 4 0.25 % Miconazole Nitrate Ointment

Search NIH Clinical Center for Cutaneous Candidiasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ciclopirox
Ciclopirox olamine
Clotrimazole
Econazole
Econazole Nitrate
Gentian Violet
Ketoconazole
Miconazole
Miconazole Nitrate
MICONAZOLE NITRATE PWDR
NYSTATIN PWDR
oxiconazole
sulconazole
Sulconazole nitrate

Cochrane evidence based reviews: candidiasis, cutaneous

Genetic Tests for Cutaneous Candidiasis

Anatomical Context for Cutaneous Candidiasis

The Foundational Model of Anatomy Ontology organs/tissues related to Cutaneous Candidiasis:

19
Skin

MalaCards organs/tissues related to Cutaneous Candidiasis:

40
Skin, Placenta, Neutrophil, Bone Marrow, Bone

Publications for Cutaneous Candidiasis

Articles related to Cutaneous Candidiasis:

(show top 50) (show all 305)
# Title Authors PMID Year
1
Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis. 61
33741400 2021
2
Exploiting solid lipid nanoparticles and nanostructured lipid carriers for drug delivery against cutaneous fungal infections. 61
33156736 2021
3
Congenital Cutaneous Candidiasis With Systemic Dissemination in a Preterm Infant: A Case Report and Review of the Literature. 61
33538540 2021
4
Oleic Acid Vesicles as a new Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar rats. 61
33176662 2020
5
Utilization of an in vitro biofabricated 3D skin as a pathological model of cutaneous candidiasis. 61
33021319 2020
6
Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis. 61
32649991 2020
7
In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis. 61
32429646 2020
8
Quinine Improves the Fungicidal Effects of Antimicrobial Blue Light: Implications for the Treatment of Cutaneous Candidiasis. 61
31746024 2020
9
Case of acne-like lesion of cutaneous candidiasis in a healthy man. 61
32147819 2020
10
A case of cutaneous candidiasis of upper eyelid in association with facial paralysis. 61
32174586 2020
11
Congenital cutaneous candidiasis associated with maternal peripartum candidemia. 61
32493666 2020
12
Chronic cutaneous candidiasis in children: should we stop there? Report of two cases associated with auto-immune polyendocrinopathy syndrome type I. 61
32188450 2020
13
In-vitro and in-vivo anticandidal activity of Trachyspermum ammi (L.) sprague seeds ethanolic extract and thymol-containing hexanes fraction. 61
32233667 2020
14
A case of Jarisch-Herxheimer reaction in candidiasis treated with systemic fluconazole. 61
32020750 2020
15
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient. 61
32118703 2020
16
Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant Candida albicans in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment. 61
32983038 2020
17
Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. 61
31287594 2019
18
Itraconazole lipid nanocapsules gel for dermatological applications: In vitro characteristics and treatment of induced cutaneous candidiasis. 61
31202972 2019
19
Cutaneous candidiasis in Tehran-Iran: from epidemiology to multilocus sequence types, virulence factors and antifungal susceptibility of etiologic Candida species. 61
31719957 2019
20
Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis. 61
30171656 2019
21
Impact of Process Parameters on Particle Size Involved in Media Milling Technique Used for Preparing Clotrimazole Nanocrystals for the Management of Cutaneous Candidiasis. 61
31028492 2019
22
Severe Cutaneous Candidiasis in a Liver Transplant Patient. 61
30891169 2019
23
Autoimmune polyglandular syndrome type 1: a case report and brief review. 61
31258868 2019
24
Management of congenital cutaneous candidiasis in a healthy term baby: A case report. 61
31588361 2019
25
Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets. 61
29447400 2018
26
Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity. 61
29873597 2018
27
Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. 61
29164434 2018
28
Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment. 61
30101725 2018
29
Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation. 61
29882446 2018
30
Cutaneous Candidiasis in a Gottingen Minipig: A Potential Pitfall in Preclinical Studies. 61
28929952 2017
31
Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions. 61
29118470 2017
32
Case of recurrent severe cellulitis and cutaneous candidiasis during psoriasis treatment with ustekinumab. 61
28432713 2017
33
Infection and tissue repair of experimental cutaneous candidiasis in diabetic mice. 61
28604330 2017
34
Effect of long-term exposure of mice to 900 MHz GSM radiation on experimental cutaneous candidiasis. 61
28490964 2017
35
Congenital Cutaneous Candidiasis: Prompt Systemic Treatment Is Associated With Improved Outcomes in Neonates. 61
28158439 2017
36
Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans. 61
29302625 2017
37
Different classes of hydrolytic enzymes produced by multidrug-resistant yeasts comprising the Candida haemulonii complex. 61
27555559 2017
38
Primary deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man: the first case report and literature review. 61
27600646 2016
39
Hydroxychavicol: A phytochemical targeting cutaneous fungal infections. 61
27897199 2016
40
Synergic effect of combination of glycyrol and fluconazole against experimental cutaneous candidiasis due to Candida albicans. 61
27572154 2016
41
Diminution of Langerhans cells in keratitis, ichthyosis and deafness (KID) syndrome patient with recalcitrant cutaneous candidiasis. 61
26333049 2016
42
Congenital cutaneous candidiasis. 61
27516110 2016
43
Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide HLR1r. 61
27155369 2016
44
Econazole imprinted textiles with antifungal activity. 61
26883854 2016
45
A retrospective study of cutaneous fungal infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000-2011. 61
28681008 2016
46
Mycological Considerations in the Topical Treatment of Superficial Fungal Infections. 61
26885799 2016
47
Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies. 61
27822033 2016
48
Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity. 61
26377898 2015
49
Immunological and histopathological characterization of cutaneous candidiasis. 61
26271575 2015
50
Vulvovaginal candidiasis in pregnancy. 61
25916994 2015

Variations for Cutaneous Candidiasis

Expression for Cutaneous Candidiasis

Search GEO for disease gene expression data for Cutaneous Candidiasis.

Pathways for Cutaneous Candidiasis

Pathways related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 IL2RA IL17RE IL17RC IL17RA IL17F IL17A
2
Show member pathways
13.06 TLR3 IL2RA IL17RC IL17RA IL17A CCR6
3
Show member pathways
12.99 IL2RA IL17RE IL17RC IL17RA IL17F IL17A
4
Show member pathways
12.99 TLR3 IL2RA IL17RE IL17RC IL17RA IL17F
5 12.18 TLR3 IL2RA IL17A CARD9
6
Show member pathways
11.89 CLEC7A CLEC6A CARD9
7
Show member pathways
11.69 IL17RE IL17RC IL17RA IL17F IL17A
8
Show member pathways
11.53 IL17RC IL17RA IL17F IL17A
9
Show member pathways
11.42 TLR3 IL17RA IL17F IL17A
10 11.4 IL2RA IL17A CCR6
11 11 IL17RC IL17F

GO Terms for Cutaneous Candidiasis

Cellular components related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 TLR3 IL2RA IL17RC CLEC7A CCR6

Biological processes related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 TLR3 IL2RA IL17A CCR6 AIRE
2 innate immune response GO:0045087 9.95 TLR3 IL17RA IL17F IL17A CLEC7A CLEC6A
3 immune system process GO:0002376 9.92 TLR3 IL2RA IL17RA IL17F IL17A CLEC7A
4 adaptive immune response GO:0002250 9.89 IL17RA IL17F IL17A CLEC6A
5 cytokine-mediated signaling pathway GO:0019221 9.85 IL2RA IL17RE IL17RC IL17F IL17A
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.77 TLR3 CLEC6A CARD9
7 inflammatory response GO:0006954 9.76 TLR3 IL2RA IL17RE IL17RC IL17RA IL17F
8 defense response to Gram-positive bacterium GO:0050830 9.74 IL17F IL17A CARD9
9 positive regulation of tumor necrosis factor production GO:0032760 9.73 TLR3 IL17A CLEC7A CARD9
10 positive regulation of interleukin-12 production GO:0032735 9.7 TLR3 IL17A CLEC7A
11 defense response to fungus GO:0050832 9.65 IL17RC IL17A CLEC6A
12 positive regulation of stress-activated MAPK cascade GO:0032874 9.58 CLEC7A CARD9
13 regulation of interleukin-6 production GO:0032675 9.58 IL17F CARD9
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.56 IL17RC IL17F IL17A CLEC7A
15 positive regulation of interleukin-23 production GO:0032747 9.55 IL17RA IL17A
16 fibroblast activation GO:0072537 9.54 IL17RA IL17A
17 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.54 IL17RA IL17F IL17A
18 regulation of interleukin-2 production GO:0032663 9.51 IL17F CARD9
19 positive regulation of interleukin-6 production GO:0032755 9.5 TLR3 IL17RC IL17RA IL17F IL17A CLEC7A
20 positive regulation of antimicrobial peptide production GO:0002225 9.49 IL17F IL17A
21 interleukin-17-mediated signaling pathway GO:0097400 9.02 IL17RE IL17RC IL17RA IL17F IL17A

Molecular functions related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-17 receptor activity GO:0030368 8.8 IL17RE IL17RC IL17RA

Sources for Cutaneous Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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