MCID: CTN033
MIFTS: 38

Cutaneous Candidiasis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Cutaneous Candidiasis

MalaCards integrated aliases for Cutaneous Candidiasis:

Name: Cutaneous Candidiasis 12 15 71
Candidiasis, Cutaneous 43

Classifications:



External Ids:

Disease Ontology 12 DOID:0080161
MeSH 43 D002179
UMLS 71 C0006846

Summaries for Cutaneous Candidiasis

Disease Ontology : 12 A candidiasis that is characterized by Candida infection located in the skin.

MalaCards based summary : Cutaneous Candidiasis, also known as candidiasis, cutaneous, is related to pustulosis of palm and sole and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Cutaneous Candidiasis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Cytochrome P-450 CYP3A Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Cutaneous Candidiasis

Diseases related to Cutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.2 IL17A CCR6
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 IL17A AIRE
3 pernicious anemia 29.9 CCR6 AIRE
4 bacterial infectious disease 29.8 TLR3 IL17A CCR6
5 keratitis, hereditary 29.8 TLR3 IL17A CCR6
6 tinea cruris 29.6 CARD9 B4GALNT2
7 tinea corporis 29.6 CARD9 B4GALNT2
8 cryptococcosis 29.4 IL17A CLEC7A CCR6
9 candidiasis 29.1 TLR3 IL17RC IL17RA IL17F IL17A CLEC7A
10 dermatitis, atopic 29.1 TLR3 IL2RA IL17F IL17A CCR6
11 autoimmune disease 29.0 IL2RA IL17F IL17A CCR6 AIRE
12 dermatophytosis 28.5 IL17A CLEC7A CCR6 CARD9 B4GALNT2
13 tinea pedis 28.4 ZNF347 CLEC7A CARD9 B4GALNT2
14 oral candidiasis 28.3 IL17RA IL17F IL17A CLEC7A CCR6 CARD9
15 chronic mucocutaneous candidiasis 26.7 TLR3 IL2RA IL17RE IL17RC IL17RA IL17F
16 nail disorder, nonsyndromic congenital, 1 10.4 CCR6 AIRE
17 vernal conjunctivitis 10.4 IL2RA CCR6
18 autoimmune polyendocrine syndrome, type ii 10.4 CCR6 AIRE
19 tuberculoid leprosy 10.3 IL2RA CCR6
20 t-cell adult acute lymphocytic leukemia 10.3 IL2RA CCR6
21 retinal vasculitis 10.3 TLR3 CCR6
22 adrenal cortical hypofunction 10.2 CCR6 AIRE
23 autoimmune enteropathy 10.2 IL2RA IL17A
24 exanthem 10.2
25 systemic autoimmune disease 10.2 IL17A AIRE
26 esophageal candidiasis 10.2 CCR6 CARD9 AIRE
27 seborrheic infantile dermatitis 10.2 IL17RE IL17RC
28 pneumonic tularemia 10.2 IL17A CCR6
29 scleral disease 10.2 IL17A CCR6
30 inflammatory bowel disease 18 10.2 IL17A CCR6
31 acute generalized exanthematous pustulosis 10.2 IL17F IL17A
32 meningovascular neurosyphilis 10.2 IL17RA IL17A
33 dacryoadenitis 10.2 IL17A CCR6
34 vulvovaginitis 10.2
35 viral pneumonia 10.1 TLR3 IL17A
36 central nervous system vasculitis 10.1 IL17A CCR6
37 tinea profunda 10.1 CLEC7A CARD9
38 neuroaspergillosis 10.1 CLEC7A CARD9
39 thymoma, familial 10.1
40 chorioamnionitis 10.1
41 thymoma 10.1
42 penicilliosis 10.1 CLEC7A CARD9
43 intestinal schistosomiasis 10.1 IL17A CCR6
44 sporotrichosis 10.1 CLEC7A CARD9
45 conjunctival disease 10.1 TLR3 IL17A CCR6
46 coccidiosis 10.1 TLR3 IL17A CCR6
47 rectal disease 10.1 TLR3 IL17A CCR6
48 common cold 10.1 TLR3 IL17A CCR6
49 nose disease 10.1 TLR3 IL17A CCR6
50 extrinsic cardiomyopathy 10.1 TLR3 IL17A CCR6

Graphical network of the top 20 diseases related to Cutaneous Candidiasis:



Diseases related to Cutaneous Candidiasis

Symptoms & Phenotypes for Cutaneous Candidiasis

MGI Mouse Phenotypes related to Cutaneous Candidiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 AIRE B4GALNT2 CARD9 CCR6 CLEC7A IL17A
2 digestive/alimentary MP:0005381 9.87 AIRE B4GALNT2 CLEC7A IL17A IL17F IL17RE
3 homeostasis/metabolism MP:0005376 9.85 AIRE B4GALNT2 CARD9 CCR6 CLEC7A IL17A
4 immune system MP:0005387 9.73 AIRE B4GALNT2 CARD9 CCR6 CLEC7A IL17A
5 respiratory system MP:0005388 9.17 AIRE CLEC7A IL17A IL17F IL17RA IL2RA

Drugs & Therapeutics for Cutaneous Candidiasis

Drugs for Cutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2 Cytochrome P-450 CYP3A Inhibitors Phase 4
3 Anti-Infective Agents Phase 4
4 Cytochrome P-450 Enzyme Inhibitors Phase 4
5 Hormone Antagonists Phase 4
6 Antifungal Agents Phase 4
7 Steroid Synthesis Inhibitors Phase 4
8 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
9 Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective 2-Year Longitudinal Study to Assess for Miconazole Resistance in Candida Spp. With Repeated Treatment Courses of 0.25% Miconazole Nitrate Ointment in Neonates and Infants up to 1 Year of Age With Recurrent Moderate-Severe Diaper Dermatitis Complicated by Cutaneous Candidiasis Completed NCT00702507 Phase 4 0.25 % Miconazole Nitrate Ointment

Search NIH Clinical Center for Cutaneous Candidiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ciclopirox
Ciclopirox olamine
Clotrimazole
Econazole
Econazole Nitrate
Gentian Violet
Ketoconazole
Miconazole
Miconazole Nitrate
MICONAZOLE NITRATE PWDR
NYSTATIN PWDR
oxiconazole
sulconazole
Sulconazole nitrate

Cochrane evidence based reviews: candidiasis, cutaneous

Genetic Tests for Cutaneous Candidiasis

Anatomical Context for Cutaneous Candidiasis

The Foundational Model of Anatomy Ontology organs/tissues related to Cutaneous Candidiasis:

19
Skin

MalaCards organs/tissues related to Cutaneous Candidiasis:

40
Skin, T Cells, Liver, Bone, Neutrophil, Placenta, Testes

Publications for Cutaneous Candidiasis

Articles related to Cutaneous Candidiasis:

(show top 50) (show all 290)
# Title Authors PMID Year
1
Quinine Improves the Fungicidal Effects of Antimicrobial Blue Light: Implications for the Treatment of Cutaneous Candidiasis. 61
31746024 2019
2
Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. 61
31287594 2019
3
Itraconazole lipid nanocapsules gel for dermatological applications: In vitro characteristics and treatment of induced cutaneous candidiasis. 61
31202972 2019
4
Cutaneous candidiasis in Tehran-Iran: from epidemiology to multilocus sequence types, virulence factors and antifungal susceptibility of etiologic Candida species. 61
31719957 2019
5
Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis. 61
30171656 2019
6
Impact of Process Parameters on Particle Size Involved in Media Milling Technique Used for Preparing Clotrimazole Nanocrystals for the Management of Cutaneous Candidiasis. 61
31028492 2019
7
Management of congenital cutaneous candidiasis in a healthy term baby: A case report. 61
31588361 2019
8
Severe Cutaneous Candidiasis in a Liver Transplant Patient. 61
30891169 2019
9
Autoimmune polyglandular syndrome type 1: a case report and brief review. 61
31258868 2019
10
Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets. 61
29447400 2018
11
Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity. 61
29873597 2018
12
Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. 61
29164434 2018
13
Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment. 61
30101725 2018
14
Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation. 61
29882446 2018
15
Cutaneous Candidiasis in a Gottingen Minipig: A Potential Pitfall in Preclinical Studies. 61
28929952 2017
16
Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions. 61
29118470 2017
17
Case of recurrent severe cellulitis and cutaneous candidiasis during psoriasis treatment with ustekinumab. 61
28432713 2017
18
Infection and tissue repair of experimental cutaneous candidiasis in diabetic mice. 61
28604330 2017
19
Effect of long-term exposure of mice to 900 MHz GSM radiation on experimental cutaneous candidiasis. 61
28490964 2017
20
Congenital Cutaneous Candidiasis: Prompt Systemic Treatment Is Associated With Improved Outcomes in Neonates. 61
28158439 2017
21
Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans. 61
29302625 2017
22
Different classes of hydrolytic enzymes produced by multidrug-resistant yeasts comprising the Candida haemulonii complex. 61
27555559 2017
23
Primary deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man: the first case report and literature review. 61
27600646 2016
24
Hydroxychavicol: A phytochemical targeting cutaneous fungal infections. 61
27897199 2016
25
Synergic effect of combination of glycyrol and fluconazole against experimental cutaneous candidiasis due to Candida albicans. 61
27572154 2016
26
Diminution of Langerhans cells in keratitis, ichthyosis and deafness (KID) syndrome patient with recalcitrant cutaneous candidiasis. 61
26333049 2016
27
Congenital cutaneous candidiasis. 61
27516110 2016
28
Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide HLR1r. 61
27155369 2016
29
Econazole imprinted textiles with antifungal activity. 61
26883854 2016
30
A retrospective study of cutaneous fungal infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000-2011. 61
28681008 2016
31
Mycological Considerations in the Topical Treatment of Superficial Fungal Infections. 61
26885799 2016
32
Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies. 61
27822033 2016
33
Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity. 61
26377898 2015
34
Immunological and histopathological characterization of cutaneous candidiasis. 61
26271575 2015
35
Vulvovaginal candidiasis in pregnancy. 61
25916994 2015
36
Novel use of terpenoids for treatment of dermatologic diseases: a systematic review of clinical trials. 61
25923990 2015
37
Protease and phospholipase activities of Candida spp. isolated from cutaneous candidiasis. 61
24853474 2015
38
Darier disease can be complicated by generalized cutaneous candidiasis: a case report. 61
25142759 2015
39
Lamisil, a potent alternative antifungal drug for otomycosis. 61
28680976 2015
40
Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis. 61
25849644 2015
41
Bioadhesive films containing fluconazole for mucocutaneous candidiasis. 61
25767319 2015
42
[2011 Epidemiological Survey of Dermatomycoses in Japan]. 61
26617109 2015
43
Treatment of cutaneous candidiasis through fluconazole encapsulated cubosomes. 61
25787202 2014
44
Dehydrated human amnion/chorion membrane for the treatment of severe skin and tissue loss in an preterm infant: a case report. 61
25296350 2014
45
Mycology - an update part 2: dermatomycoses: clinical picture and diagnostics. 61
25176455 2014
46
Polymeric microparticles-based formulation for the eradication of cutaneous candidiasis: development and characterization. 61
23560821 2014
47
Paediatric oropharyngeal and cutaneous candidiasis with special reference to Candida dubliniensis. 61
24445508 2014
48
Oleic acid vesicles: a new approach for topical delivery of antifungal agent. 61
23656670 2014
49
Animal models for candidiasis. 61
24700323 2014
50
Primary cutaneous Candida tropicalis infection in a patient with B-cell lymphoma. 61
24818181 2014

Variations for Cutaneous Candidiasis

Expression for Cutaneous Candidiasis

Search GEO for disease gene expression data for Cutaneous Candidiasis.

Pathways for Cutaneous Candidiasis

Pathways related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 TLR3 IL2RA IL17RE IL17RC IL17RA IL17F
2
Show member pathways
13.34 IL2RA IL17RE IL17RC IL17RA IL17F IL17A
3
Show member pathways
13.03 TLR3 IL2RA IL17RC IL17RA IL17A CCR6
4
Show member pathways
12.96 IL2RA IL17RE IL17RC IL17RA IL17F IL17A
5 12.14 TLR3 IL2RA IL17A CARD9
6
Show member pathways
11.72 TLR3 IL17F IL17A
7
Show member pathways
11.36 IL17RE IL17RC IL17RA IL17F IL17A
8 11.34 IL2RA IL17A CCR6
9
Show member pathways
11.23 IL17RC IL17RA IL17F IL17A

GO Terms for Cutaneous Candidiasis

Cellular components related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 TLR3 IL2RA IL17RC CLEC7A CCR6

Biological processes related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 IL2RA IL17A CCR6 AIRE
2 inflammatory response GO:0006954 9.8 TLR3 IL17RE IL17F IL17A CLEC7A
3 cytokine-mediated signaling pathway GO:0019221 9.55 IL2RA IL17RE IL17RC IL17F IL17A
4 positive regulation of interleukin-6 secretion GO:2000778 9.54 IL17RC IL17F IL17A
5 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.51 TLR3 CLEC7A
6 granulocyte chemotaxis GO:0071621 9.49 IL17RC IL17RA
7 positive regulation of interleukin-23 production GO:0032747 9.48 IL17RA IL17A
8 regulation of interleukin-6 biosynthetic process GO:0045408 9.46 IL17F CARD9
9 fibroblast activation GO:0072537 9.43 IL17RA IL17A
10 defense response to fungus GO:0050832 9.43 IL17RC IL17RA IL17A
11 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.35 IL17RC IL17RA IL17F IL17A CLEC7A
12 regulation of interleukin-2 biosynthetic process GO:0045076 9.32 IL17F CARD9
13 interleukin-17-mediated signaling pathway GO:0097400 9.02 IL17RE IL17RC IL17RA IL17F IL17A

Molecular functions related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-17 receptor activity GO:0030368 8.8 IL17RE IL17RC IL17RA

Sources for Cutaneous Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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