MCID: CTN033
MIFTS: 30

Cutaneous Candidiasis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Cutaneous Candidiasis

MalaCards integrated aliases for Cutaneous Candidiasis:

Name: Cutaneous Candidiasis 12 15 72
Candidiasis, Cutaneous 44

Classifications:



External Ids:

Disease Ontology 12 DOID:0080161
MeSH 44 D002179
UMLS 72 C0006846

Summaries for Cutaneous Candidiasis

Disease Ontology : 12 A candidiasis that is characterized by Candida infection located in the skin.

MalaCards based summary : Cutaneous Candidiasis, also known as candidiasis, cutaneous, is related to candidiasis and exanthem. An important gene associated with Cutaneous Candidiasis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways is MAPK Pathway. The drugs Miconazole and 14-alpha Demethylase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and neutrophil.

Related Diseases for Cutaneous Candidiasis

Diseases related to Cutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 candidiasis 10.9
2 exanthem 10.2
3 vulvovaginitis 10.2
4 thymoma, familial 10.1
5 chorioamnionitis 10.1
6 oral candidiasis 10.1
7 chronic mucocutaneous candidiasis 10.1
8 thymoma 10.1
9 funisitis 10.0
10 paronychia 10.0
11 vaginitis 10.0
12 dermatophytosis 10.0
13 neonatal candidiasis 10.0
14 candida glabrata 10.0
15 mycosis fungoides 10.0
16 aplastic anemia 10.0
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
18 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
19 dermatomycosis 10.0
20 keratosis 10.0
21 neurodermatitis 10.0
22 skin disease 10.0
23 myopathy 10.0
24 pustulosis of palm and sole 10.0
25 folliculitis 10.0
26 psoriasis 10.0
27 alopecia 10.0
28 kid syndrome 10.0
29 alcohol dependence 9.8
30 autoimmune disease 9.8
31 candidiasis, familial, 1 9.8
32 keratitis, hereditary 9.8
33 pernicious anemia 9.8
34 candidiasis, familial, 2 9.8
35 pulmonary alveolar microlithiasis 9.8
36 branchiootic syndrome 1 9.8
37 dermatitis, atopic 9.8
38 deficiency anemia 9.8
39 good syndrome 9.8
40 lymphoma 9.8
41 cutaneous t cell lymphoma 9.8
42 hyper ige syndrome 9.8
43 endometritis 9.8
44 ehrlichiosis 9.8
45 bacterial infectious disease 9.8
46 tinea cruris 9.8
47 allergic hypersensitivity disease 9.8
48 cryptococcosis 9.8
49 tinea corporis 9.8
50 leukemia 9.8

Graphical network of the top 20 diseases related to Cutaneous Candidiasis:



Diseases related to Cutaneous Candidiasis

Symptoms & Phenotypes for Cutaneous Candidiasis

Drugs & Therapeutics for Cutaneous Candidiasis

Drugs for Cutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2 14-alpha Demethylase Inhibitors Phase 4
3 Hormones Phase 4
4 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
5 Cytochrome P-450 CYP3A Inhibitors Phase 4
6 Antifungal Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Steroid Synthesis Inhibitors Phase 4
9 Anti-Infective Agents Phase 4
10 Hormone Antagonists Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective 2-Year Longitudinal Study to Assess for Miconazole Resistance in Candida Spp. With Repeated Treatment Courses of 0.25% Miconazole Nitrate Ointment in Neonates and Infants up to 1 Year of Age With Recurrent Moderate-Severe Diaper Dermatitis Complicated by Cutaneous Candidiasis Completed NCT00702507 Phase 4 0.25 % Miconazole Nitrate Ointment

Search NIH Clinical Center for Cutaneous Candidiasis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


ciclopirox
Ciclopirox
Ciclopirox olamine
Clotrimazole
Clotrimazole
Econazole
Econazole
Econazole Nitrate
Gentian Violet
Ketoconazole
Miconazole
Miconazole Nitrate
MICONAZOLE NITRATE PWDR
NYSTATIN PWDR
oxiconazole
sulconazole
Sulconazole nitrate
Terbinafine
Triamcinolone

Cochrane evidence based reviews: candidiasis, cutaneous

Genetic Tests for Cutaneous Candidiasis

Anatomical Context for Cutaneous Candidiasis

MalaCards organs/tissues related to Cutaneous Candidiasis:

41
Skin, Liver, Neutrophil, Testes, Placenta, B Cells, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Cutaneous Candidiasis:

19
Skin

Publications for Cutaneous Candidiasis

Articles related to Cutaneous Candidiasis:

(show top 50) (show all 287)
# Title Authors PMID Year
1
Itraconazole lipid nanocapsules gel for dermatological applications: In vitro characteristics and treatment of induced cutaneous candidiasis. 38
31202972 2019
2
Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. 38
31287594 2019
3
Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis. 38
30171656 2019
4
Impact of Process Parameters on Particle Size Involved in Media Milling Technique Used for Preparing Clotrimazole Nanocrystals for the Management of Cutaneous Candidiasis. 38
31028492 2019
5
Severe Cutaneous Candidiasis in a Liver Transplant Patient. 38
30891169 2019
6
Autoimmune polyglandular syndrome type 1: a case report and brief review. 38
31258868 2019
7
Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity. 38
29873597 2018
8
Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. 38
29164434 2018
9
Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets. 38
29447400 2018
10
Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment. 38
30101725 2018
11
Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation. 38
29882446 2018
12
Cutaneous Candidiasis in a Gottingen Minipig: A Potential Pitfall in Preclinical Studies. 38
28929952 2017
13
Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions. 38
29118470 2017
14
Case of recurrent severe cellulitis and cutaneous candidiasis during psoriasis treatment with ustekinumab. 38
28432713 2017
15
Infection and tissue repair of experimental cutaneous candidiasis in diabetic mice. 38
28604330 2017
16
Effect of long-term exposure of mice to 900 MHz GSM radiation on experimental cutaneous candidiasis. 38
28490964 2017
17
Congenital Cutaneous Candidiasis: Prompt Systemic Treatment Is Associated With Improved Outcomes in Neonates. 38
28158439 2017
18
Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans. 38
29302625 2017
19
Different classes of hydrolytic enzymes produced by multidrug-resistant yeasts comprising the Candida haemulonii complex. 38
27555559 2017
20
Primary deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man: the first case report and literature review. 38
27600646 2016
21
Hydroxychavicol: A phytochemical targeting cutaneous fungal infections. 38
27897199 2016
22
Synergic effect of combination of glycyrol and fluconazole against experimental cutaneous candidiasis due to Candida albicans. 38
27572154 2016
23
Diminution of Langerhans cells in keratitis, ichthyosis and deafness (KID) syndrome patient with recalcitrant cutaneous candidiasis. 38
26333049 2016
24
Congenital cutaneous candidiasis. 38
27516110 2016
25
Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide HLR1r. 38
27155369 2016
26
Econazole imprinted textiles with antifungal activity. 38
26883854 2016
27
A retrospective study of cutaneous fungal infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000-2011. 38
28681008 2016
28
Mycological Considerations in the Topical Treatment of Superficial Fungal Infections. 38
26885799 2016
29
Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies. 38
27822033 2016
30
Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity. 38
26377898 2015
31
Immunological and histopathological characterization of cutaneous candidiasis. 38
26271575 2015
32
Vulvovaginal candidiasis in pregnancy. 38
25916994 2015
33
Novel use of terpenoids for treatment of dermatologic diseases: a systematic review of clinical trials. 38
25923990 2015
34
Protease and phospholipase activities of Candida spp. isolated from cutaneous candidiasis. 38
24853474 2015
35
Darier disease can be complicated by generalized cutaneous candidiasis: a case report. 38
25142759 2015
36
Lamisil, a potent alternative antifungal drug for otomycosis. 38
28680976 2015
37
Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis. 38
25849644 2015
38
[2011 Epidemiological Survey of Dermatomycoses in Japan]. 38
26617109 2015
39
Bioadhesive films containing fluconazole for mucocutaneous candidiasis. 38
25767319 2015
40
Treatment of cutaneous candidiasis through fluconazole encapsulated cubosomes. 38
25787202 2014
41
Dehydrated human amnion/chorion membrane for the treatment of severe skin and tissue loss in an preterm infant: a case report. 38
25296350 2014
42
Mycology - an update part 2: dermatomycoses: clinical picture and diagnostics. 38
25176455 2014
43
Polymeric microparticles-based formulation for the eradication of cutaneous candidiasis: development and characterization. 38
23560821 2014
44
Paediatric oropharyngeal and cutaneous candidiasis with special reference to Candida dubliniensis. 38
24445508 2014
45
Animal models for candidiasis. 38
24700323 2014
46
Oleic acid vesicles: a new approach for topical delivery of antifungal agent. 38
23656670 2014
47
Primary cutaneous Candida tropicalis infection in a patient with B-cell lymphoma. 38
24818181 2014
48
Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency. 38
24186907 2014
49
[Congenital cutaneous candidiasis]. 38
24196777 2013
50
Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis. 38
24196340 2013

Variations for Cutaneous Candidiasis

Expression for Cutaneous Candidiasis

Search GEO for disease gene expression data for Cutaneous Candidiasis.

Pathways for Cutaneous Candidiasis

Pathways related to Cutaneous Candidiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.72 TLR3 IL2RA

GO Terms for Cutaneous Candidiasis

Sources for Cutaneous Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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