MCID: CTN004
MIFTS: 39

Cutaneous Fibrous Histiocytoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Cutaneous Fibrous Histiocytoma

MalaCards integrated aliases for Cutaneous Fibrous Histiocytoma:

Name: Cutaneous Fibrous Histiocytoma 12 52 15 17 71
Dermatofibroma 12 74 52 54
Fibrohistiocytic Tumor 12 71
Benign Cutaneous Fibrous Histiocytoma 12
Fibrous Histiocytoma of Skin 12
Sclerosing Angioma of Skin 12
Fibrous Xanthoma of Skin 12
Pleomorphic Fibroma 12
Sclerosing Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4418
MeSH 43 D018219
NCIt 49 C6801 C8402
SNOMED-CT 67 254749001 448015002
UMLS 71 C0002991 C0346049

Summaries for Cutaneous Fibrous Histiocytoma

NIH Rare Diseases : 52 Dermatofibroma is a common benign skin nodule . It frequently develops on the extremities (most often the lower legs). Although it is generally not associated with any signs or symptoms, some affected people may experience itching and/or tenderness. Dermatofibromas are found in people of all ages and ethnicity and are more commonly diagnosed in women than men. The underlying cause of dermatofibroma is currently unknown. Treatment is generally not required, but if symptoms are present, the lesion can be surgically removed.

MalaCards based summary : Cutaneous Fibrous Histiocytoma, also known as dermatofibroma, is related to fibromatosis and pyogenic granuloma. An important gene associated with Cutaneous Fibrous Histiocytoma is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Innate Immune System and Hematopoietic cell lineage. Affiliated tissues include skin, breast and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 A dermatofibroma, or benign fibrous histiocytomas, is a benign skin... more...

Related Diseases for Cutaneous Fibrous Histiocytoma

Diseases related to Cutaneous Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 fibromatosis 30.8 VIM DES ACTC1
2 pyogenic granuloma 30.6 CD34 ACTC1
3 myopericytoma 30.4 S100B ACTC1
4 rare tumor 30.4 DES ACTC1
5 pleomorphic lipoma 30.3 SERPINA3 CD68 CD34
6 fasciitis 30.3 VIM CD34 ACTC1
7 malignant giant cell tumor 30.3 S100B CD68 ACTC1
8 granuloma annulare 30.2 VIM F13A1 CD68
9 spindle cell lipoma 30.2 VIM DES CD34 ACTC1
10 epithelioid sarcoma 30.1 VIM CD68 CD34
11 langerhans cell histiocytosis 30.1 S100B F13A1 CD68
12 liposarcoma 30.1 VIM DES CD68 CD34
13 amelanotic melanoma 30.1 SERPINA3 S100B MLANA
14 fibrous histiocytoma 30.0 VIM SERPINA3 S100B F13A1 DES CD68
15 juvenile xanthogranuloma 29.9 SERPINA3 S100B S100A1 MLANA F13A1
16 hemangioma 29.9 PDGFB CD68 CD34 ACTC1
17 benign giant cell tumor 29.9 VIM SERPINA3 DES CD68 ACTC1
18 lipomatosis, multiple 29.9 SERPINA3 MLANA DES CD34
19 pleomorphic liposarcoma 29.9 VIM SERPINA3 S100B DES ACTC1
20 infantile myofibromatosis 29.8 VIM PDGFB DES CD34 ACTC1
21 spindle cell sarcoma 29.8 VIM SERPINA3 S100B DES CD34 ACTC1
22 pilomatrixoma 29.8 S100B PAGR1 CLEC2A
23 malignant fibrous histiocytoma 29.7 VIM SERPINA3 S100B F13A1 DES CD68
24 myxofibrosarcoma 29.7 SERPINA3 S100B PAGR1 DES CD34
25 endometrial stromal sarcoma 29.6 VIM S100B MME DES ACTC1
26 fibroma 29.5 VIM SERPINA3 S100A1 F13A1 DES CD68
27 fibrosarcoma 29.5 VIM PDGFB DES COL1A1 ACTC1
28 malignant granular cell myoblastoma 29.5 SERPINA3 MLANA CD68 CD34
29 sarcoma 29.5 VIM SERPINA3 S100B S100A1 PDGFB DES
30 leiomyoma 29.3 VIM S100A1 MME DES CD34 ACTC1
31 bednar tumor 29.3 VIM S100B PDGFB COL1A1
32 granular cell tumor 29.3 VIM SERPINA3 S100B S100A1 MLANA DES
33 mesenchymal cell neoplasm 29.2 SERPINA3 MME MLANA CD68 CD34
34 leiomyosarcoma 29.1 VIM SERPINA3 S100B S100A1 MLANA DES
35 cutaneous leiomyosarcoma 29.0 VIM S100B FOXO4 DES CLEC2A ACTC1
36 vascular cancer 28.9 SERPINA3 MME MLANA CD68 CD34
37 smooth muscle tumor 28.9 VIM SERPINA3 S100A1 MME DES CD34
38 neurilemmoma 28.8 VIM SERPINA3 S100B S100A1 MLANA DES
39 neurofibroma 28.8 VIM S100B S100A1 MLANA KITLG F13A1
40 hemangiopericytoma, malignant 28.6 VIM SERPINA3 S100B MLANA F13A1 DES
41 pseudosarcomatous fibromatosis 28.4 VIM SERPINA3 DES COL1A1 CD68 CD34
42 skin benign neoplasm 28.1 SERPINA3 MLANA COL1A1 CLEC2A CD68 CD34
43 dermatofibrosarcoma protuberans 28.0 VIM SERPINA3 S100B S100A1 PDGFB MMP11
44 connective tissue benign neoplasm 27.5 SERPINA3 PAGR1 MME MLANA FOXO4 CLEC2A
45 malignant skin fibrous histiocytoma 11.7
46 sclerosing hemangioma 11.6
47 clear cell acanthoma 11.5
48 tumor of meninges 10.6 VIM F13A1
49 basal cell carcinoma 10.6
50 infantile digital fibromatosis 10.6 VIM DES

Graphical network of the top 20 diseases related to Cutaneous Fibrous Histiocytoma:



Diseases related to Cutaneous Fibrous Histiocytoma

Symptoms & Phenotypes for Cutaneous Fibrous Histiocytoma

MGI Mouse Phenotypes related to Cutaneous Fibrous Histiocytoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 ACTC1 COL1A1 DES F13A1 KITLG MMP11
2 homeostasis/metabolism MP:0005376 9.8 ACTC1 CD34 COL1A1 DES F13A1 FOXO4
3 integument MP:0010771 9.28 CD34 COL1A1 KITLG MLANA MME MMP11

Drugs & Therapeutics for Cutaneous Fibrous Histiocytoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas Active, not recruiting NCT03392935

Search NIH Clinical Center for Cutaneous Fibrous Histiocytoma

Genetic Tests for Cutaneous Fibrous Histiocytoma

Anatomical Context for Cutaneous Fibrous Histiocytoma

MalaCards organs/tissues related to Cutaneous Fibrous Histiocytoma:

40
Skin, Breast, Bone, Lung, Lymph Node, Smooth Muscle, Testes

Publications for Cutaneous Fibrous Histiocytoma

Articles related to Cutaneous Fibrous Histiocytoma:

(show top 50) (show all 745)
# Title Authors PMID Year
1
PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. 61 54
19663837 2010
2
Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34. 61 54
17596171 2007
3
High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors. 54 61
16740036 2006
4
Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa. 54 61
16640542 2006
5
Characterization of factor XIIIa+ dendritic cells in dermatofibroma: Immunohistochemical, electron and immunoelectron microscopical observations. 61 54
16055004 2005
6
Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity. 54 61
15249855 2004
7
Dermatofibrosarcoma protuberans--an update. 61 54
16279228 2004
8
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. 61 54
15016298 2004
9
Solitary sclerotic fibroma of skin: a possible link with pleomorphic fibroma with immunophenotypic expression for O13 (CD99) and CD34. 61 54
14744088 2003
10
Expression of desmin and smooth muscle myosin heavy chain in dermatofibromas. 54 61
12296754 2002
11
Stromelysin 3 expression: a useful marker for the differential diagnosis dermatofibroma versus dermatofibrosarcoma protuberans. 54 61
11862177 2002
12
Type XVI collagen is expressed in factor XIIIa+ monocyte-derived dermal dendrocytes and constitutes a potential substrate for factor XIIIa. 61 54
11841543 2002
13
A light microscopic and immunohistochemical evaluation of scars. 54 61
11841514 2002
14
The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. 54 61
11564169 2001
15
Tenascin differentiates dermatofibroma from dermatofibrosarcoma protuberans: comparison with CD34 and factor XIIIa. 61 54
11172295 2001
16
Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders. 61 54
10233668 1999
17
Expression of cathepsins in dermal fibrous tumors: an immunohistochemical study. 61 54
9649659 1998
18
Granular cell dermatofibroma. 61 54
9354896 1997
19
Verocay body--prominent cutaneous schwannoma. 54 61
9185909 1997
20
LN-2 (CD74). A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. 61 54
9179057 1997
21
CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma. 54 61
9129699 1997
22
Stromelysin-3 mRNA associated with myofibroblasts is overexpressed in aggressive basal cell carcinoma and in dermatofibroma but not in dermatofibrosarcoma. 54 61
8757754 1996
23
Impaired expression of stem cell factor in dermatofibroma fibroblasts. 54 61
8869678 1996
24
Atrophic variants of dermatofibroma and dermatofibrosarcoma protuberans. 54 61
7545142 1995
25
Dermatofibroma and dermatofibrosarcoma protuberans: differential expression of CD34 and factor XIIIa. 54 61
7528477 1994
26
Epithelioid cell histiocytoma. A report of 10 cases including a new cellular variant. 54 61
7909998 1994
27
CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. 54 61
7694515 1993
28
Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics. 61
31999365 2020
29
Features of dermatofibroma in reflectance confocal microscopy. 61
32496610 2020
30
Congenital multiple clustered dermatofibroma on the abdomen. 61
32390156 2020
31
Desmoplastic stromal changes in cutaneous neural granular cell tumors: An under-recognized histopathologic feature of diagnostic and prognostic importance. 61
31859431 2020
32
Granuloma annulare mimicking eruptive dermatofibroma in an HIV-positive male: A challenge with distinct dermatoscopic findings. 61
32246518 2020
33
Fat necrosis with an associated lymphocytic infiltrate represents a histopathologic clue that distinguishes cellular dermatofibroma from dermatofibrosarcoma protuberans. 61
32412128 2020
34
Fibrous histiocytoma/dermatofibroma in children: the same as adults? 61
32246988 2020
35
Multicoloured rainbow pattern in a case of aneurysmal dermatofibroma. 61
32342492 2020
36
Prospective Study of Q Switched Alexandrite Laser 755 nm and V Beam Pulsed Dye Laser 595 nm in Dermatofibroma. 61
31615627 2020
37
Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas. 61
31493396 2020
38
State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS). 61
31777957 2020
39
Could cathepsin-k be a driver of the myofibroblastic differentiation observed in dermatofibroma, atypical fibroxanthoma and pleomorphic dermal sarcoma? 61
31889532 2020
40
Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions. 61
32190505 2020
41
Dermoscopy Training Effect on Diagnostic Accuracy of Skin Lesions in Canadian Family Medicine Physicians Using the Triage Amalgamated Dermoscopic Algorithm. 61
32363097 2020
42
Dermatopathological characteristics of dermatofibromas from dermatoscopic clues. 61
31264200 2020
43
Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances? 61
31653978 2020
44
Hemosiderotic Dermatofibroma: A Rare and Atypical Variant Capable of Clinically Resembling Melanoma. 61
32133258 2020
45
Basal Cell Carcinoma Overlying a Dermatofibroma: A Rare Collision Tumor. 61
31921502 2020
46
Epithelioid Fibrous Histiocytoma: A Concise Review. 61
30289773 2019
47
Spectral indexes obtained by implementation of the fractional Fourier and Hermite transform for the diagnosis of malignant melanoma. 61
31853384 2019
48
Cellular Dermatofibroma: Clinicopathologic Review of 218 Cases of Cellular Dermatofibroma to Determine the Clinical Recurrence Rate. 61
30741794 2019
49
Perineural Invasion as a Clue to Malignant Behavior in a Dermatofibroma. 61
31725481 2019
50
Plaque-like dermatofibroma with satellitosis in a young woman. 61
30239985 2019

Variations for Cutaneous Fibrous Histiocytoma

Expression for Cutaneous Fibrous Histiocytoma

Search GEO for disease gene expression data for Cutaneous Fibrous Histiocytoma.

Pathways for Cutaneous Fibrous Histiocytoma

GO Terms for Cutaneous Fibrous Histiocytoma

Cellular components related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SERPINA3 S100B S100A1 PDGFB MMP11 KITLG
2 platelet alpha granule lumen GO:0031093 8.8 SERPINA3 PDGFB F13A1

Biological processes related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paracrine signaling GO:0038001 8.96 PDGFB CD34
2 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.65 S100B S100A1 PDGFB MME CLEC2A
2 identical protein binding GO:0042802 9.17 VIM S100B S100A1 PDGFB FOXO4 DES
3 S100 protein binding GO:0044548 9.16 S100B S100A1
4 platelet-derived growth factor binding GO:0048407 8.96 PDGFB COL1A1

Sources for Cutaneous Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....