MCID: CTN004
MIFTS: 41

Cutaneous Fibrous Histiocytoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Cutaneous Fibrous Histiocytoma

MalaCards integrated aliases for Cutaneous Fibrous Histiocytoma:

Name: Cutaneous Fibrous Histiocytoma 12 52 15 17 71
Dermatofibroma 12 74 52 54
Fibrohistiocytic Tumor 12 71
Benign Cutaneous Fibrous Histiocytoma 12
Dermatofibroma, No Icd-O Subtype 12
Fibrous Histiocytoma of Skin 12
Sclerosing Angioma of Skin 12
Fibrohistiocytic Neoplasm 12
Fibrous Xanthoma of Skin 12
Pleomorphic Fibroma 12
Sclerosing Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4418
MeSH 43 D018219
NCIt 49 C6801 C8402
SNOMED-CT 67 72079004
UMLS 71 C0002991 C0346049

Summaries for Cutaneous Fibrous Histiocytoma

NIH Rare Diseases : 52 Dermatofibroma is a common benign skin nodule . It frequently develops on the extremities (most often the lower legs). Although it is generally not associated with any signs or symptoms, some affected people may experience itching and/or tenderness. Dermatofibromas are found in people of all ages and ethnicity and are more commonly diagnosed in women than men. The underlying cause of dermatofibroma is currently unknown. Treatment is generally not required, but if symptoms are present, the lesion can be surgically removed.

MalaCards based summary : Cutaneous Fibrous Histiocytoma, also known as dermatofibroma, is related to histiocytoma and fibromatosis. An important gene associated with Cutaneous Fibrous Histiocytoma is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Dopamine and Methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 74 A dermatofibroma, or benign fibrous histiocytomas, is a benign skin... more...

Related Diseases for Cutaneous Fibrous Histiocytoma

Diseases related to Cutaneous Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 417)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 32.0 VIM SERPINA3 MITF CD68 CD34 ACTC1
2 fibromatosis 30.9 VIM DES ACTC1
3 myxofibrosarcoma 30.8 S100B DES
4 pyogenic granuloma 30.6 CD34 ACTC1
5 pleomorphic lipoma 30.6 SERPINA3 CD34
6 dowling-degos disease 1 30.5 MITF KITLG
7 myopericytoma 30.5 S100B ACTC1
8 fibrosarcoma 30.4 VIM PDGFB DES ACTC1
9 rare tumor 30.4 DES ACTC1
10 connective tissue benign neoplasm 30.3 SERPINA3 CD68 CD34
11 malignant giant cell tumor 30.3 S100B CD68 ACTC1
12 bednar tumor 30.3 VIM S100B PDGFB
13 pleomorphic liposarcoma 30.2 VIM S100B DES ACTC1
14 spindle cell lipoma 30.2 VIM DES CD34 ACTC1
15 infantile myofibromatosis 30.2 VIM DES CD34 ACTC1
16 langerhans cell histiocytosis 30.2 S100B F13A1 CD68
17 epithelioid sarcoma 30.2 VIM CD68 CD34
18 liposarcoma 30.1 VIM DES CD68 CD34
19 fasciitis 30.1 VIM DES CD34 ACTC1
20 clear cell sarcoma 30.1 S100B MLANA MITF
21 juvenile xanthogranuloma 30.0 SERPINA3 S100B S100A1 MLANA F13A1
22 lipomatosis, multiple 30.0 SERPINA3 MLANA DES CD34
23 hemangioma 30.0 PDGFB CD68 CD34 ACTC1
24 malignant granular cell myoblastoma 29.8 SERPINA3 MLANA CD68
25 spindle cell sarcoma 29.8 VIM SERPINA3 S100B DES CD34 ACTC1
26 skin benign neoplasm 29.7 SERPINA3 CLEC2A CD68 CD34
27 giant cell tumor 29.5 VIM SERPINA3 S100B DES CD68 ACTC1
28 fibroma 29.5 VIM SERPINA3 S100A1 F13A1 DES CD68
29 amelanotic melanoma 29.4 VIM SERPINA3 S100B MLANA MITF
30 fibrous histiocytoma 29.4 VIM SERPINA3 S100B MITF F13A1 DES
31 granular cell tumor 29.4 VIM SERPINA3 S100B S100A1 MLANA DES
32 pseudosarcomatous fibromatosis 29.3 VIM SERPINA3 DES CD68 CD34 ACTC1
33 endometrial stromal sarcoma 29.3 VIM S100B MME DES ACTC1
34 malignant fibroxanthoma 29.2 VIM SERPINA3 FOXO4 F13A1 DES CD68
35 hemangiopericytoma, malignant 29.2 VIM SERPINA3 S100B F13A1 DES CD34
36 leiomyosarcoma 29.2 VIM SERPINA3 S100B S100A1 MLANA DES
37 cutaneous leiomyosarcoma 29.2 VIM S100B FOXO4 DES CLEC2A ACTC1
38 leiomyoma 29.0 VIM S100A1 MME DES CD34 ACTC1
39 mesenchymal cell neoplasm 28.9 SERPINA3 MME MLANA CD68 CD34
40 dermatofibrosarcoma protuberans 28.9 VIM SERPINA3 S100B S100A1 PDGFB MMP11
41 neurilemmoma 28.8 VIM SERPINA3 S100B S100A1 MITF DES
42 smooth muscle tumor 28.5 VIM SERPINA3 S100A1 MME DES CD34
43 neurofibroma 28.3 VIM S100B S100A1 MLANA MITF KITLG
44 vascular cancer 28.1 SERPINA3 MME MLANA MITF CD68 CD34
45 malignant skin fibrous histiocytoma 11.7
46 clear cell acanthoma 11.5
47 sclerosing hemangioma 11.5
48 tumor of meninges 10.6 VIM F13A1
49 infantile digital fibromatosis 10.6 VIM DES
50 generalized eruptive histiocytosis 10.6 S100B F13A1

Graphical network of the top 20 diseases related to Cutaneous Fibrous Histiocytoma:



Diseases related to Cutaneous Fibrous Histiocytoma

Symptoms & Phenotypes for Cutaneous Fibrous Histiocytoma

MGI Mouse Phenotypes related to Cutaneous Fibrous Histiocytoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 ACTC1 CD34 DES F13A1 FOXO4 KITLG
2 integument MP:0010771 9.23 CD34 KITLG MITF MLANA MME MMP11

Drugs & Therapeutics for Cutaneous Fibrous Histiocytoma

Drugs for Cutaneous Fibrous Histiocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved 51-61-6, 62-31-7 681
2
Methamphetamine Approved, Illicit 537-46-2 10836
3 Neurotransmitter Agents
4 Sympathomimetics
5 Dopamine Uptake Inhibitors
6 Dopamine Agents
7 Central Nervous System Stimulants
8 Autonomic Agents
9 Adrenergic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas Active, not recruiting NCT03392935

Search NIH Clinical Center for Cutaneous Fibrous Histiocytoma

Genetic Tests for Cutaneous Fibrous Histiocytoma

Anatomical Context for Cutaneous Fibrous Histiocytoma

MalaCards organs/tissues related to Cutaneous Fibrous Histiocytoma:

40
Skin, Breast, Bone, Heart, Lung, Smooth Muscle, B Cells

Publications for Cutaneous Fibrous Histiocytoma

Articles related to Cutaneous Fibrous Histiocytoma:

(show top 50) (show all 736)
# Title Authors PMID Year
1
PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. 54 61
19663837 2010
2
Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34. 54 61
17596171 2007
3
High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors. 54 61
16740036 2006
4
Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa. 54 61
16640542 2006
5
Characterization of factor XIIIa+ dendritic cells in dermatofibroma: Immunohistochemical, electron and immunoelectron microscopical observations. 54 61
16055004 2005
6
Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity. 54 61
15249855 2004
7
Dermatofibrosarcoma protuberans--an update. 54 61
16279228 2004
8
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. 54 61
15016298 2004
9
Solitary sclerotic fibroma of skin: a possible link with pleomorphic fibroma with immunophenotypic expression for O13 (CD99) and CD34. 54 61
14744088 2003
10
Expression of desmin and smooth muscle myosin heavy chain in dermatofibromas. 54 61
12296754 2002
11
Stromelysin 3 expression: a useful marker for the differential diagnosis dermatofibroma versus dermatofibrosarcoma protuberans. 54 61
11862177 2002
12
Type XVI collagen is expressed in factor XIIIa+ monocyte-derived dermal dendrocytes and constitutes a potential substrate for factor XIIIa. 54 61
11841543 2002
13
A light microscopic and immunohistochemical evaluation of scars. 54 61
11841514 2002
14
The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. 54 61
11564169 2001
15
Tenascin differentiates dermatofibroma from dermatofibrosarcoma protuberans: comparison with CD34 and factor XIIIa. 54 61
11172295 2001
16
Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders. 54 61
10233668 1999
17
Expression of cathepsins in dermal fibrous tumors: an immunohistochemical study. 54 61
9649659 1998
18
Granular cell dermatofibroma. 54 61
9354896 1997
19
Verocay body--prominent cutaneous schwannoma. 54 61
9185909 1997
20
LN-2 (CD74). A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. 54 61
9179057 1997
21
CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma. 54 61
9129699 1997
22
Stromelysin-3 mRNA associated with myofibroblasts is overexpressed in aggressive basal cell carcinoma and in dermatofibroma but not in dermatofibrosarcoma. 54 61
8757754 1996
23
Impaired expression of stem cell factor in dermatofibroma fibroblasts. 54 61
8869678 1996
24
Atrophic variants of dermatofibroma and dermatofibrosarcoma protuberans. 54 61
7545142 1995
25
Dermatofibroma and dermatofibrosarcoma protuberans: differential expression of CD34 and factor XIIIa. 54 61
7528477 1994
26
Epithelioid cell histiocytoma. A report of 10 cases including a new cellular variant. 54 61
7909998 1994
27
CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. 54 61
7694515 1993
28
State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS). 61
31777957 2020
29
Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances? 61
31653978 2020
30
Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics. 61
31999365 2020
31
Basal Cell Carcinoma Overlying a Dermatofibroma: A Rare Collision Tumor. 61
31921502 2020
32
Epithelioid Fibrous Histiocytoma: A Concise Review. 61
30289773 2019
33
Spectral indexes obtained by implementation of the fractional Fourier and Hermite transform for the diagnosis of malignant melanoma. 61
31853384 2019
34
Could cathepsin-k be a driver of the myofibroblastic differentiation observed in dermatofibroma, atypical fibroxanthoma and pleomorphic dermal sarcoma? 61
31889532 2019
35
Desmoplastic stromal changes in cutaneous neural granular cell tumors: An under-recognized histopathologic feature of diagnostic and prognostic importance. 61
31859431 2019
36
Cellular Dermatofibroma: Clinicopathologic Review of 218 Cases of Cellular Dermatofibroma to Determine the Clinical Recurrence Rate. 61
30741794 2019
37
Perineural Invasion as a Clue to Malignant Behavior in a Dermatofibroma. 61
31725481 2019
38
Prospective Study of Q Switched Alexandrite Laser 755 nm and V Beam Pulsed Dye Laser 595 nm in Dermatofibroma. 61
31615627 2019
39
Plaque-like dermatofibroma with satellitosis in a young woman. 61
30239985 2019
40
Dermatofibroma With Sebaceous Induction: Dermoscopic Clues to Improve Recognition. 61
31723473 2019
41
High-frequency ultrasound in the diagnosis of selected non-melanoma skin nodular lesions. 61
31839774 2019
42
A Rare Case of Atrophic Dermatofibroma Featuring Linear Skin Dimple. 61
31616278 2019
43
Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection. 61
29629953 2019
44
A Case of Atrophic Dermatofibroma Overexpressing Matrix Metalloproteinase-1. 61
31616280 2019
45
Dermoscopic patterns of dermatofibroma in 72 Chinese patients. 61
31425360 2019
46
Small Benign Storiform Fibrous Tumor (Fibrous Histiocytoma) of the Conjunctival Substantia Propria in a Child: Review and Clarification of Biologic Behavior. 61
30893190 2019
47
SOX9 Immunohistochemistry in the Distinction of Angiomatoid Fibrous Histiocytoma From Histologic Mimics: Diagnostic Utility and Pitfalls. 61
31567275 2019
48
Atrophic Dermatofibroma: A Comprehensive Literature Review. 61
31338755 2019
49
Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas. 61
31493396 2019
50
Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. 61
30927287 2019

Variations for Cutaneous Fibrous Histiocytoma

Expression for Cutaneous Fibrous Histiocytoma

Search GEO for disease gene expression data for Cutaneous Fibrous Histiocytoma.

Pathways for Cutaneous Fibrous Histiocytoma

GO Terms for Cutaneous Fibrous Histiocytoma

Cellular components related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.8 SERPINA3 PDGFB F13A1

Biological processes related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.55 VIM PDGFB MITF CD34 ACTC1
2 intermediate filament organization GO:0045109 9.26 VIM DES
3 paracrine signaling GO:0038001 8.96 PDGFB CD34
4 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 S100 protein binding GO:0044548 8.62 S100B S100A1

Sources for Cutaneous Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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