MCID: CTN004
MIFTS: 39

Cutaneous Fibrous Histiocytoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Cutaneous Fibrous Histiocytoma

MalaCards integrated aliases for Cutaneous Fibrous Histiocytoma:

Name: Cutaneous Fibrous Histiocytoma 12 20 15 17 71
Dermatofibroma 12 74 20 54
Fibrohistiocytic Tumor 12 71
Benign Cutaneous Fibrous Histiocytoma 12
Fibrous Histiocytoma of Skin 12
Sclerosing Angioma of Skin 12
Fibrous Xanthoma of Skin 12
Pleomorphic Fibroma 12
Sclerosing Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4418
MeSH 44 D018219
NCIt 50 C6801 C8402
SNOMED-CT 67 254749001 403999006
UMLS 71 C0002991 C0346049

Summaries for Cutaneous Fibrous Histiocytoma

GARD : 20 Dermatofibroma is a common benign skin nodule. It frequently develops on the extremities (most often the lower legs). Although it is generally not associated with any signs or symptoms, some affected people may experience itching and/or tenderness. Dermatofibromas are found in people of all ages and ethnicity and are more commonly diagnosed in women than men. The underlying cause of dermatofibroma is currently unknown. Treatment is generally not required, but if symptoms are present, the lesion can be surgically removed.

MalaCards based summary : Cutaneous Fibrous Histiocytoma, also known as dermatofibroma, is related to fibromatosis and well-differentiated liposarcoma. An important gene associated with Cutaneous Fibrous Histiocytoma is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. Affiliated tissues include skin, smooth muscle and eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 A dermatofibroma, or benign fibrous histiocytomas, is a benign skin... more...

Related Diseases for Cutaneous Fibrous Histiocytoma

Diseases related to Cutaneous Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)
# Related Disease Score Top Affiliating Genes
1 fibromatosis 30.6 VIM DES ACTC1
2 well-differentiated liposarcoma 30.3 SERPINA3 MLANA CD34
3 pleomorphic lipoma 30.2 SERPINA3 CD68 CD34
4 fibrous histiocytoma 30.2 VIM SERPINA3 S100B F13A1 DES CD68
5 myopericytoma 30.2 S100B ACTC1
6 rare tumor 30.1 DES ACTC1
7 langerhans cell histiocytosis 30.1 S100B F13A1 CD68
8 malignant giant cell tumor 30.1 S100B CD68 ACTC1
9 spindle cell lipoma 30.1 VIM DES CD34 ACTC1
10 fasciitis 30.0 VIM CD34 ACTC1
11 liposarcoma 30.0 VIM DES CD68 CD34
12 granuloma annulare 29.9 VIM F13A1 CD68
13 lipomatosis, multiple 29.9 SERPINA3 MLANA DES CD34
14 epithelioid sarcoma 29.9 VIM CD68 CD34
15 spindle cell sarcoma 29.9 VIM SERPINA3 S100B DES CD34 ACTC1
16 pleomorphic liposarcoma 29.8 VIM SERPINA3 S100B DES ACTC1
17 infantile myofibromatosis 29.8 VIM PDGFB DES CD34 ACTC1
18 fibrosarcoma 29.7 VIM PDGFB DES COL1A1 ACTC1
19 malignant fibrous histiocytoma 29.7 VIM SERPINA3 S100B F13A1 DES CD68
20 myxofibrosarcoma 29.6 SERPINA3 S100B PAGR1 DES CD34
21 malignant granular cell myoblastoma 29.6 SERPINA3 MLANA CD68
22 juvenile xanthogranuloma 29.6 SERPINA3 S100B S100A1 MLANA F13A1
23 fibroma 29.6 VIM SERPINA3 S100A1 F13A1 DES CD68
24 giant cell reparative granuloma 29.6 SERPINA3 CD68
25 amelanotic melanoma 29.6 VIM SERPINA3 S100B MLANA
26 neurilemmoma 29.5 VIM SERPINA3 S100B S100A1 DES CD34
27 cutaneous leiomyosarcoma 29.5 VIM S100B DES CD68 CD34 ACTC1
28 vascular cancer 29.4 SERPINA3 MLANA CD68 CD34
29 granular cell tumor 29.4 VIM SERPINA3 S100B S100A1 MLANA DES
30 endometrial stromal sarcoma 29.4 VIM S100B MME DES ACTC1
31 leiomyosarcoma 29.3 VIM SERPINA3 S100B S100A1 MLANA DES
32 hemangiopericytoma, malignant 29.2 VIM SERPINA3 S100B F13A1 DES CD34
33 leiomyoma 29.2 VIM S100A1 MME DES CD34 ACTC1
34 mesenchymal cell neoplasm 29.1 SERPINA3 MME MLANA CD68 CD34
35 skin carcinoma 29.1 MME MLANA KITLG CD68 CD34
36 neurofibroma 28.9 VIM S100B S100A1 MLANA KITLG F13A1
37 skin benign neoplasm 28.9 SERPINA3 MLANA COL1A1 CD68 CD34
38 pseudosarcomatous fibromatosis 28.7 VIM SERPINA3 DES COL1A1 CD68 CD34
39 dermatofibrosarcoma protuberans 28.7 VIM SERPINA3 S100B S100A1 PDGFB MMP11
40 connective tissue benign neoplasm 28.6 SERPINA3 PAGR1 MME MLANA CD68 CD34
41 malignant skin fibrous histiocytoma 11.5
42 sclerosing hemangioma 11.3
43 clear cell acanthoma 11.0
44 tumor of meninges 10.4 VIM F13A1
45 basal cell carcinoma 10.4
46 infantile digital fibromatosis 10.4 VIM DES
47 generalized eruptive histiocytosis 10.4 S100B F13A1
48 primitive neuroectodermal tumor of the cervix uteri 10.4 VIM DES
49 lymphangiomatosis 10.4 VIM DES
50 hydromyelia 10.4 VIM S100B

Graphical network of the top 20 diseases related to Cutaneous Fibrous Histiocytoma:



Diseases related to Cutaneous Fibrous Histiocytoma

Symptoms & Phenotypes for Cutaneous Fibrous Histiocytoma

MGI Mouse Phenotypes related to Cutaneous Fibrous Histiocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ACTC1 COL1A1 DES F13A1 KITLG MME
2 homeostasis/metabolism MP:0005376 9.77 ACTC1 CD34 COL1A1 DES F13A1 KITLG
3 integument MP:0010771 9.32 CD34 COL1A1 F13A1 KITLG MLANA MME

Drugs & Therapeutics for Cutaneous Fibrous Histiocytoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas Active, not recruiting NCT03392935

Search NIH Clinical Center for Cutaneous Fibrous Histiocytoma

Genetic Tests for Cutaneous Fibrous Histiocytoma

Anatomical Context for Cutaneous Fibrous Histiocytoma

MalaCards organs/tissues related to Cutaneous Fibrous Histiocytoma:

40
Skin, Smooth Muscle, Eye, Lymph Node, Thyroid, Prostate, Endothelial

Publications for Cutaneous Fibrous Histiocytoma

Articles related to Cutaneous Fibrous Histiocytoma:

(show top 50) (show all 764)
# Title Authors PMID Year
1
PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. 54 61
19663837 2010
2
Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34. 61 54
17596171 2007
3
High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors. 54 61
16740036 2006
4
Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa. 61 54
16640542 2006
5
Characterization of factor XIIIa+ dendritic cells in dermatofibroma: Immunohistochemical, electron and immunoelectron microscopical observations. 61 54
16055004 2005
6
Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity. 54 61
15249855 2004
7
Dermatofibrosarcoma protuberans--an update. 54 61
16279228 2004
8
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. 61 54
15016298 2004
9
Solitary sclerotic fibroma of skin: a possible link with pleomorphic fibroma with immunophenotypic expression for O13 (CD99) and CD34. 61 54
14744088 2003
10
Expression of desmin and smooth muscle myosin heavy chain in dermatofibromas. 54 61
12296754 2002
11
Stromelysin 3 expression: a useful marker for the differential diagnosis dermatofibroma versus dermatofibrosarcoma protuberans. 61 54
11862177 2002
12
Type XVI collagen is expressed in factor XIIIa+ monocyte-derived dermal dendrocytes and constitutes a potential substrate for factor XIIIa. 54 61
11841543 2002
13
A light microscopic and immunohistochemical evaluation of scars. 54 61
11841514 2002
14
The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. 61 54
11564169 2001
15
Tenascin differentiates dermatofibroma from dermatofibrosarcoma protuberans: comparison with CD34 and factor XIIIa. 61 54
11172295 2001
16
Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders. 61 54
10233668 1999
17
Expression of cathepsins in dermal fibrous tumors: an immunohistochemical study. 61 54
9649659 1998
18
Granular cell dermatofibroma. 54 61
9354896 1997
19
LN-2 (CD74). A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. 54 61
9179057 1997
20
Verocay body--prominent cutaneous schwannoma. 61 54
9185909 1997
21
CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma. 61 54
9129699 1997
22
Stromelysin-3 mRNA associated with myofibroblasts is overexpressed in aggressive basal cell carcinoma and in dermatofibroma but not in dermatofibrosarcoma. 54 61
8757754 1996
23
Impaired expression of stem cell factor in dermatofibroma fibroblasts. 54 61
8869678 1996
24
Atrophic variants of dermatofibroma and dermatofibrosarcoma protuberans. 54 61
7545142 1995
25
Dermatofibroma and dermatofibrosarcoma protuberans: differential expression of CD34 and factor XIIIa. 61 54
7528477 1994
26
Epithelioid cell histiocytoma. A report of 10 cases including a new cellular variant. 61 54
7909998 1994
27
CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. 61 54
7694515 1993
28
Role of Wnt signaling in dermatofibroma induction phenomenon. 61
32767564 2021
29
[Differential diagnosis dermatofibroma]. 61
33398388 2021
30
Rosettes in T-cell pseudolymphoma: a new dermoscopic finding. 61
33288369 2021
31
A rare case of atrophic dermatofibroma with dermoscopic findings. 61
33403769 2021
32
Basal cell carcinoma in dermatofibroma: Dual diagnosis. 61
33254214 2020
33
A Deep Learning Approach to Skin Cancer Detection in Dermoscopy Images. 61
33364218 2020
34
Positive MITF and NKI/C3 Expression in Cellular Neurothekeoma and Dermatofibroma. 61
33264109 2020
35
Multicoloured rainbow pattern in a case of aneurysmal dermatofibroma. 61
32342492 2020
36
Dermatofibroma Botryoides on Nipple: A Report. 61
33487729 2020
37
[Anatomoclinical and immunohistochemical study of 8 cases of dermatomyofibroma]. 61
33059951 2020
38
Fat necrosis with an associated lymphocytic infiltrate represents a histopathologic clue that distinguishes cellular dermatofibroma from dermatofibrosarcoma protuberans. 61
32412128 2020
39
Classification of Skin Lesions into Seven Classes Using Transfer Learning with AlexNet. 61
32607904 2020
40
Congenital multiple clustered dermatofibroma on the abdomen. 61
32390156 2020
41
Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma. 61
32711930 2020
42
A Clinicohistopathological Analysis of Cutaneous Fibrous Histiocytomas of the Finger. 61
33165359 2020
43
SOX9 Immunohistochemistry in the Distinction of Angiomatoid Fibrous Histiocytoma From Histologic Mimics: Diagnostic Utility and Pitfalls. 61
31567275 2020
44
Cutaneous Leiomyoma Mimicking a Keloid. 61
32876039 2020
45
Features of dermatofibroma in reflectance confocal microscopy. 61
32496610 2020
46
Mohs Surgery for Cellular Dermatofibroma in a Child. 61
32796324 2020
47
Perineural Invasion as a Clue to Malignant Behavior in a Dermatofibroma. 61
31725481 2020
48
Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics. 61
31999365 2020
49
Fibrous histiocytoma/dermatofibroma in children: the same as adults? 61
32246988 2020
50
Granuloma annulare mimicking eruptive dermatofibroma in an HIV-positive male: A challenge with distinct dermatoscopic findings. 61
32246518 2020

Variations for Cutaneous Fibrous Histiocytoma

Expression for Cutaneous Fibrous Histiocytoma

Search GEO for disease gene expression data for Cutaneous Fibrous Histiocytoma.

Pathways for Cutaneous Fibrous Histiocytoma

GO Terms for Cutaneous Fibrous Histiocytoma

Cellular components related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 SERPINA3 S100B S100A1 PDGFB MMP11 KITLG
2 platelet alpha granule lumen GO:0031093 9.13 SERPINA3 PDGFB F13A1

Biological processes related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.33 SERPINA3 PDGFB F13A1
2 intermediate filament organization GO:0045109 9.26 VIM DES
3 paracrine signaling GO:0038001 8.96 PDGFB CD34
4 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Cutaneous Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 S100 protein binding GO:0044548 8.96 S100B S100A1
2 platelet-derived growth factor binding GO:0048407 8.62 PDGFB COL1A1

Sources for Cutaneous Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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