MCID: CTN010
MIFTS: 28

Cutaneous Ganglioneuroma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Ganglioneuroma

MalaCards integrated aliases for Cutaneous Ganglioneuroma:

Name: Cutaneous Ganglioneuroma 12 15
Ganglioneuroma of Skin 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2425
NCIt 49 C4481
UMLS 71 C0346063

Summaries for Cutaneous Ganglioneuroma

MalaCards based summary : Cutaneous Ganglioneuroma, also known as ganglioneuroma of skin, is related to gangliocytoma and ganglioneuroma. An important gene associated with Cutaneous Ganglioneuroma is CNP (2',3'-Cyclic Nucleotide 3' Phosphodiesterase), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, lung and breast, and related phenotypes are cellular and nervous system

Related Diseases for Cutaneous Ganglioneuroma

Diseases related to Cutaneous Ganglioneuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 30.8 SYP CHGA
2 ganglioneuroma 30.3 SYP NCAM1 ENO2 CHGA
3 thyroid gland medullary carcinoma 29.7 SYP ENO2 CHGA
4 neurofibroma 28.6 SYP MITF KIT CNP CD34
5 neuroblastoma 28.1 SYP NCAM1 KIT ENO2 CHGA APP
6 vulvar apocrine adenocarcinoma 10.4 KRT20 ENO2
7 vaginal glandular tumor 10.3 ENO2 CHGA
8 choriocarcinoma of ovary 10.3 NCAM1 ENO2
9 breast rhabdomyosarcoma 10.3 NCAM1 ENO2
10 gastric gastrinoma 10.3 ENO2 CHGA
11 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
12 bile duct adenoma 10.3 NCAM1 KRT20
13 eyelid benign neoplasm 10.3 KRT20 CHGA
14 penis sarcoma 10.3 ENO2 CD34
15 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
16 cerebral neuroblastoma 10.3 SYP ENO2
17 angiomyoma 10.3 ENO2 CD34
18 pacinian tumor 10.3 ENO2 CD34
19 papillary tumor of the pineal region 10.3 SYP ENO2
20 middle cerebral artery infarction 10.3 NCAM1 ENO2
21 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
22 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
23 nodular prostate 10.3 SYP ENO2
24 cloacogenic carcinoma 10.3 SYP ENO2
25 appendix lymphoma 10.3 ENO2 CHGA
26 female urethral cancer 10.3 KRT20 CHGA
27 angiomatous meningioma 10.3 ENO2 CD34
28 mature teratoma of the ovary 10.3 SYP ENO2
29 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
30 lung combined type small cell carcinoma 10.3 SYP NCAM1
31 spindle cell thymoma 10.3 ENO2 CD34
32 jejunal cancer 10.3 KRT20 CHGA
33 cerebellar liponeurocytoma 10.2 SYP ENO2
34 papillary ependymoma 10.2 SYP ENO2
35 optic nerve astrocytoma 10.2 SYP ENO2
36 hypoganglionosis 10.2 SYP NCAM1
37 frontal lobe neoplasm 10.2 SYP ENO2
38 pineal parenchymal tumor of intermediate differentiation 10.2 SYP ENO2
39 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT20 ENO2
40 adrenal neuroblastoma 10.2 SYP ENO2
41 aortic malignant tumor 10.2 KRT20 CD34
42 glycogen-rich clear cell breast carcinoma 10.2 SYP KRT20
43 congenital granular cell tumor 10.2 ENO2 CD34
44 extraskeletal ewing sarcoma 10.2 SYP ENO2
45 vulvar leiomyoma 10.2 NCAM1 CD34
46 rhabdoid meningioma 10.2 SYP ENO2
47 spinal cord oligodendroglioma 10.2 SYP ENO2
48 colonic lymphangioma 10.2 KRT20 CD34
49 krukenberg carcinoma 10.2 SYP KRT20
50 biliary tract benign neoplasm 10.2 SYP NCAM1

Graphical network of the top 20 diseases related to Cutaneous Ganglioneuroma:



Diseases related to Cutaneous Ganglioneuroma

Symptoms & Phenotypes for Cutaneous Ganglioneuroma

MGI Mouse Phenotypes related to Cutaneous Ganglioneuroma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 APP CD34 CNP ENO2 GNS KIT
2 nervous system MP:0003631 9.28 APP CHGA CNP ENO2 GNS KIT

Drugs & Therapeutics for Cutaneous Ganglioneuroma

Search Clinical Trials , NIH Clinical Center for Cutaneous Ganglioneuroma

Genetic Tests for Cutaneous Ganglioneuroma

Anatomical Context for Cutaneous Ganglioneuroma

MalaCards organs/tissues related to Cutaneous Ganglioneuroma:

40
Skin, Lung, Breast, Small Intestine, Colon, Thyroid, Ovary

Publications for Cutaneous Ganglioneuroma

Articles related to Cutaneous Ganglioneuroma:

(show all 16)
# Title Authors PMID Year
1
Cutaneous ganglioneuroma: A case report and discussion of the literature. 61
30632184 2019
2
Primary cutaneous ganglioneuroma: anatomico-clinical study of 4 cases with focus on Merkel cells. 61
29569258 2018
3
Ganglion cell like cells, diagnostic dilemma. 61
23919032 2013
4
Primary cutaneous ganglioneuroma of the finger mimicking verruca vulgaris: a case report. 61
22719011 2013
5
Acquired primary cutaneous ganglioneuroma with adipocytic metaplasia: "An end point of melanocytic 'maturation'?" a case report and meta-analysis with comparison to a cross-sectional study of neurotized melanocytic nevi. 61
21048488 2011
6
[Facial primary cutaneous ganglioneuroma]. 61
19364589 2009
7
Cutaneous ganglioneuroma associated with overlying hyperkeratotic epidermal changes: a report of 2 cases. 61
19033938 2008
8
Cutaneous ganglioneuroma. 61
17651174 2007
9
Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association. 61
15725239 2005
10
Cutaneous ganglioneuroma within a giant congenital nevus. 61
24223002 2005
11
Primary cutaneous ganglioneuroma: a report of two cases and literature review. 61
12775986 2003
12
A case of cutaneous ganglioneuroma developing within a lesion of seborrheic keratosis. 61
12081162 2002
13
Desmoplastic cutaneous ganglioneuroma. 61
9934592 1999
14
Primary congenital cutaneous ganglioneuroma. 61
8698926 1996
15
Cutaneous ganglioneuromas: a case report and review of the literature. 61
8698321 1996
16
Cutaneous ganglion cell choristoma. Report of a case. 61
1774358 1991

Variations for Cutaneous Ganglioneuroma

Expression for Cutaneous Ganglioneuroma

Search GEO for disease gene expression data for Cutaneous Ganglioneuroma.

Pathways for Cutaneous Ganglioneuroma

Pathways related to Cutaneous Ganglioneuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 SYP NCAM1 ENO2 CNP APP
2 11.5 NCAM1 KIT CD34
3 11.23 NCAM1 KIT CD34
4 11 NCAM1 KIT CD34

GO Terms for Cutaneous Ganglioneuroma

Cellular components related to Cutaneous Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.1 SYP S100A6 CNP CHGA CD34 APP
2 mast cell granule GO:0042629 8.96 KIT CHGA

Biological processes related to Cutaneous Ganglioneuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 MITF KIT CD34 APP
2 melanocyte differentiation GO:0030318 9.4 MITF KIT
3 axonogenesis GO:0007409 9.33 S100A6 CNP APP
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.32 SYP APP
5 mast cell degranulation GO:0043303 9.26 KIT CHGA
6 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
7 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Sources for Cutaneous Ganglioneuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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