MCID: CTN012
MIFTS: 29

Cutaneous Leiomyosarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

MalaCards integrated aliases for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 15 70
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 50 C4484
SNOMED-CT 67 254771006
UMLS 70 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to rare tumor and leiomyosarcoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include skin, smooth muscle and lymph node.

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 rare tumor 30.4 DES ACTC1
2 leiomyosarcoma 30.3 VIM S100B MUC1 FH DES ACTC1
3 epithelioid leiomyosarcoma 29.8 VIM MUC1 DES ACTC1
4 malignant mesenchymoma 29.5 DES CD34 CALD1
5 intravenous leiomyomatosis 29.3 DES CD34 CALD1
6 medulloblastoma 29.2 VIM S100B GFAP DES ACTC1
7 mesenchymal cell neoplasm 29.1 CD68 CD34 CALD1
8 connective tissue benign neoplasm 29.1 CD68 CD34 CALD1
9 epithelioid sarcoma 29.1 VIM MUC1 CD68 CD34
10 liposarcoma 29.0 VIM DES CD68 CD34
11 angiosarcoma 28.9 VIM MUC1 CD68 CD34
12 leiomyoma 28.9 VIM FH DES CD34 ACTC1
13 syringocystadenoma papilliferum 28.8 VIM S100B MUC1 GFAP DES ACTC1
14 dermatofibrosarcoma protuberans 28.7 VIM S100B DES CD34 ACTC1
15 fibroma 28.7 VIM DES CD68 CD34 ACTC1
16 smooth muscle tumor 28.6 VIM DES CD34 CALD1 ACTC1
17 cutaneous fibrous histiocytoma 28.3 VIM S100B DES CD68 CD34 ACTC1
18 soft tissue sarcoma 10.4
19 fibroblastic rheumatism 10.3 DES ACTC1
20 ovarian fibrothecoma 10.3 DES ACTC1
21 adult cystic nephroma 10.3 DES ACTC1
22 anaplastic ganglioglioma 10.3 GFAP ACTC1
23 pulmonary vein stenosis 10.3 DES ACTC1
24 gliomatosis peritonei 10.3 GFAP DES
25 botryoid rhabdomyosarcoma 10.3 DES ACTC1
26 medullomyoblastoma 10.2 GFAP DES
27 spindle cell thymoma 10.2 MUC1 DES
28 binswanger's disease 10.2 GFAP ACTC1
29 myopericytoma 10.2 S100B ACTC1
30 papillary ependymoma 10.2 S100B GFAP
31 epithelioid trophoblastic tumor 10.2 MUC1 ACTC1
32 lymphangiectasis 10.2 VIM ACTC1
33 plasmablastic lymphoma 10.2 MUC1 DES
34 malignant triton tumor 10.2 S100B DES
35 intravascular papillary endothelial hyperplasia 10.2 VIM ACTC1
36 sclerosing perineurioma 10.2 S100B MUC1
37 localized hypertrophic neuropathy 10.2 S100B MUC1
38 reticular perineurioma 10.2 S100B MUC1
39 infantile digital fibromatosis 10.2 VIM DES
40 pineocytoma 10.2 S100B GFAP
41 giant cell myocarditis 10.2 DES CD68
42 lymphangiomatosis 10.2 VIM DES
43 aggressive digital papillary adenocarcinoma 10.2 S100B MUC1
44 meningeal melanocytoma 10.2 S100B MUC1
45 light chain deposition disease 10.2 CD68 ACTC1
46 cerebral primitive neuroectodermal tumor 10.2 S100B MUC1
47 ovarian benign neoplasm 10.2 MUC1 DES
48 non-functioning pituitary adenoma 10.2 S100B MUC1
49 proximal spinal muscular atrophy 10.2 MUC1 DES
50 gemistocytic astrocytoma 10.2 S100B GFAP

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

40
Skin, Smooth Muscle, Lymph Node

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 146)
# Title Authors PMID Year
1
Cutaneous Sarcomas. 61
33602520 2021
2
[Infiltration of the skull by dedifferentiated cutaneous leiomyosarcoma]. 61
33760962 2021
3
Cutaneous leiomyosarcoma: a 20-year retrospective study and review of the literature. 61
33775481 2021
4
Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review. 61
33543674 2021
5
Exophytic nodule resembling a horn - an unusual presentation of metastatic cutaneous leiomyosarcoma. 61
32686093 2021
6
Advanced Cutaneous Leiomyosarcoma of the Forearm. 61
33673555 2021
7
Cutaneous leiomyosarcoma mimicking arteriovenous malformation. 61
33363774 2020
8
A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations. 61
32540221 2020
9
Cutaneous leiomyosarcoma: dermal and subcutaneous. 61
32537765 2020
10
Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics. 61
31999365 2020
11
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited: Corrigendum. 61
32282499 2020
12
Leiomyosarcoma of the skin: review of the literature with an emphasis on prognosis and management. 61
31729020 2020
13
Cutaneous Leiomyosarcoma: A SEER Database Analysis. 61
31306276 2020
14
Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report. 61
32355488 2020
15
Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study. 61
30932400 2019
16
Cutaneous Sarcomas. 61
30497679 2019
17
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment. 61
30409380 2019
18
Primary cutaneous vascular leiomyosarcoma: A rare subtype of leiomyosarcoma of the skin. 61
29740853 2018
19
Primary leiomyosarcoma of the skin: a comprehensive review on diagnosis and treatment. 61
30140957 2018
20
Advanced Magnetic Resonance Imaging in the Evaluation of a Chronic Non-healing ulcer - A Case Report of Rare Primary Cutaneous Leiomyosarcoma. 61
30687652 2018
21
Leiomyosarcoma of the head and neck: A 17-year single institution experience and review of the National Cancer Data Base. 61
29286183 2018
22
Cutaneous Leiomyosarcoma: On the Importance of Histologic Location. 61
29233527 2018
23
Cutaneous leiomyosarcoma on the face. 61
29723357 2018
24
Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation with Prognosis in 12 Patients. 61
29100621 2018
25
Cutaneous leiomyosarcoma on the face. 61
33287977 2018
26
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome: A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. 61
28475508 2018
27
Cutaneous leiomyosarcoma on the trunk: An unusual presentation with an aggressive course - Case report and review of literature. 61
31068995 2018
28
Cutaneous Leiomyosarcoma of the Face. 61
28913324 2017
29
Cutaneous Leiomyosarcoma with Multiple Visceral Metastases in a Domestic Pigeon. 61
28665730 2017
30
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. 61
28177971 2017
31
Periorbital leiomyosarcoma treated by means of conventional surgery and frontal myocutaneous flap. 61
29267467 2017
32
Subcutaneous Leiomyosarcoma Metastasized to the Lymph Nodes Involved with Small Lymphocytic Lymphoma / Chronic Lymphocytic Leukemia. 61
28272651 2017
33
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of the fumarate hydratase gene. 61
25913776 2016
34
Incidence of mature adipocytic component within cutaneous smooth muscle neoplasms. 61
27404774 2016
35
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. 61
26787636 2016
36
S100A6 expression in cutaneous smooth muscle neoplasms. 61
26238340 2015
37
Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX. 61
26098709 2015
38
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. 61
26276213 2015
39
Recurrent cutaneous leiomyosarcoma of the inner thigh. 61
25900934 2015
40
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. 61
26516329 2015
41
[Cutaneous and subcutaneous leiomyosarcoma: report of two cases]. 61
25780967 2014
42
Leiomyosarcoma of the skin: clinical, histopathologic, and prognostic factors that influence outcomes. 61
25174541 2014
43
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. 61
25263848 2014
44
Cutaneous leiomyosarcoma - Case report. 61
25408738 2014
45
Leiomyosarcoma of the Face. 61
28913187 2014
46
Pleomorphic dermal neoplasms: a review. 61
24508694 2014
47
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. 61
24077407 2013
48
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. 61
23984230 2013
49
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. 61
23851868 2013
50
Rapid growing superficial cutaneous leiomyosarcoma of the face. 61
23717020 2013

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 VIM MUC1 DES CALD1 ACTC1
2
Show member pathways
11.47 VIM GFAP DES
3 11.23 VIM S100B GFAP
4 10.99 VIM DES ACTC1

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.65 VIM GFAP DES CALD1 ACTC1
2 cytoplasm GO:0005737 9.61 VIM S100B MUC1 GFAP FH DES
3 intermediate filament GO:0005882 9.33 VIM GFAP DES
4 intermediate filament cytoskeleton GO:0045111 8.8 VIM GFAP DES

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte development GO:0014002 9.32 VIM GFAP
2 Bergmann glial cell differentiation GO:0060020 9.26 VIM GFAP
3 intermediate filament-based process GO:0045103 9.16 VIM GFAP
4 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
5 intermediate filament organization GO:0045109 8.8 VIM GFAP DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myosin binding GO:0017022 8.96 CALD1 ACTC1
2 structural constituent of cytoskeleton GO:0005200 8.8 VIM GFAP DES

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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