MCID: CTN012
MIFTS: 29

Cutaneous Leiomyosarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

MalaCards integrated aliases for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 15 71
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 49 C4484
SNOMED-CT 67 254771006
UMLS 71 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to rare tumor and malignant mesenchymoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include skin, smooth muscle and lymph node.

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 rare tumor 30.5 DES ACTC1
2 malignant mesenchymoma 30.2 DES CALD1
3 intravenous leiomyomatosis 30.0 DES CALD1
4 leiomyosarcoma 29.9 VIM S100B MUC1 FH DES ACTC1
5 fibroma 29.7 VIM DES ACTC1
6 leiomyoma 29.4 VIM FH DES ACTC1
7 epithelioid sarcoma 29.3 VIM MUC1
8 dermatofibrosarcoma protuberans 29.2 VIM S100B DES ACTC1
9 syringocystadenoma papilliferum 29.0 S100B MUC1 GFAP DES ACTC1
10 epithelioid leiomyosarcoma 28.9 VIM MUC1 DES CALD1 ACTC1
11 smooth muscle tumor 28.8 VIM FH DES CALD1 ACTC1
12 spindle cell sarcoma 28.8 VIM S100B MUC1 DES ACTC1
13 medulloblastoma 28.7 VIM S100B GFAP DES ACTC1
14 cutaneous fibrous histiocytoma 27.6 VIM S100B FOXO4 DES CLEC2A ACTC1
15 fibroblastic rheumatism 10.4 DES ACTC1
16 ovarian fibrothecoma 10.4 DES ACTC1
17 anaplastic ganglioglioma 10.4 GFAP ACTC1
18 adult cystic nephroma 10.4 DES ACTC1
19 pulmonary vein stenosis 10.4 DES ACTC1
20 botryoid rhabdomyosarcoma 10.3 DES ACTC1
21 gliomatosis peritonei 10.3 GFAP DES
22 non-langerhans-cell histiocytosis 10.3 DES ACTC1
23 binswanger's disease 10.3 GFAP ACTC1
24 medullomyoblastoma 10.3 GFAP DES
25 spindle cell thymoma 10.3 MUC1 DES
26 myopericytoma 10.3 S100B ACTC1
27 papillary ependymoma 10.3 S100B GFAP
28 malignant giant cell tumor 10.3 S100B ACTC1
29 plasmablastic lymphoma 10.3 MUC1 DES
30 spindle cell rhabdomyosarcoma 10.3 GFAP DES
31 myofibroma 10.3 DES CALD1
32 lymphangiectasis 10.3 VIM ACTC1
33 malignant triton tumor 10.2 S100B DES
34 intravascular papillary endothelial hyperplasia 10.2 VIM ACTC1
35 gastric leiomyoma 10.2 FH CALD1
36 malignant giant cell tumor of soft parts 10.2 S100B ACTC1
37 sclerosing perineurioma 10.2 S100B MUC1
38 localized hypertrophic neuropathy 10.2 S100B MUC1
39 proximal spinal muscular atrophy 10.2 MUC1 DES
40 infantile digital fibromatosis 10.2 VIM DES
41 reticular perineurioma 10.2 S100B MUC1
42 pineocytoma 10.2 S100B GFAP
43 lymphangiomatosis 10.2 VIM DES
44 aggressive digital papillary adenocarcinoma 10.2 S100B MUC1
45 ovarian benign neoplasm 10.2 MUC1 DES
46 non-functioning pituitary adenoma 10.2 S100B MUC1
47 cerebral primitive neuroectodermal tumor 10.2 S100B MUC1
48 breast myoepithelial carcinoma 10.2 VIM ACTC1
49 congenital epulis 10.2 VIM DES
50 epulis 10.2 VIM DES

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

40
Skin, Smooth Muscle, Lymph Node, Adipocyte

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 138)
# Title Authors PMID Year
1
Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics. 61
31999365 2020
2
A Genomic Survey of Sarcomas on Sun-Exposed Skin Reveals Distinctive Candidate Drivers and Potentially Targetable Mutations. 61
32540221 2020
3
Cutaneous leiomyosarcoma: dermal and subcutaneous. 61
32537765 2020
4
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited: Corrigendum. 61
32282499 2020
5
Leiomyosarcoma of the skin: review of the literature with an emphasis on prognosis and management. 61
31729020 2020
6
Cutaneous Leiomyosarcoma: A SEER Database Analysis. 61
31306276 2020
7
Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report. 61
32355488 2020
8
Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study. 61
30932400 2019
9
Cutaneous Sarcomas. 61
30497679 2019
10
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment. 61
30409380 2019
11
Primary cutaneous vascular leiomyosarcoma: A rare subtype of leiomyosarcoma of the skin. 61
29740853 2018
12
Primary leiomyosarcoma of the skin: a comprehensive review on diagnosis and treatment. 61
30140957 2018
13
Advanced Magnetic Resonance Imaging in the Evaluation of a Chronic Non-healing ulcer - A Case Report of Rare Primary Cutaneous Leiomyosarcoma. 61
30687652 2018
14
Leiomyosarcoma of the head and neck: A 17-year single institution experience and review of the National Cancer Data Base. 61
29286183 2018
15
Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation with Prognosis in 12 Patients. 61
29100621 2018
16
Cutaneous Leiomyosarcoma: On the Importance of Histologic Location. 61
29233527 2018
17
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome: A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. 61
28475508 2018
18
Cutaneous leiomyosarcoma on the face. 61
29723357 2018
19
Cutaneous leiomyosarcoma on the trunk: An unusual presentation with an aggressive course - Case report and review of literature. 61
31068995 2018
20
Cutaneous Leiomyosarcoma with Multiple Visceral Metastases in a Domestic Pigeon. 61
28665730 2017
21
Cutaneous Leiomyosarcoma of the Face. 61
28913324 2017
22
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. 61
28177971 2017
23
Periorbital leiomyosarcoma treated by means of conventional surgery and frontal myocutaneous flap. 61
29267467 2017
24
Subcutaneous Leiomyosarcoma Metastasized to the Lymph Nodes Involved with Small Lymphocytic Lymphoma / Chronic Lymphocytic Leukemia. 61
28272651 2017
25
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of the fumarate hydratase gene. 61
25913776 2016
26
Incidence of mature adipocytic component within cutaneous smooth muscle neoplasms. 61
27404774 2016
27
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. 61
26787636 2016
28
S100A6 expression in cutaneous smooth muscle neoplasms. 61
26238340 2015
29
Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX. 61
26098709 2015
30
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. 61
26276213 2015
31
Recurrent cutaneous leiomyosarcoma of the inner thigh. 61
25900934 2015
32
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. 61
26516329 2015
33
[Cutaneous and subcutaneous leiomyosarcoma: report of two cases]. 61
25780967 2014
34
Leiomyosarcoma of the skin: clinical, histopathologic, and prognostic factors that influence outcomes. 61
25174541 2014
35
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. 61
25263848 2014
36
Cutaneous leiomyosarcoma - Case report. 61
25408738 2014
37
Leiomyosarcoma of the Face. 61
28913187 2014
38
Pleomorphic dermal neoplasms: a review. 61
24508694 2014
39
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. 61
24077407 2013
40
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. 61
23851868 2013
41
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. 61
23984230 2013
42
Rapid growing superficial cutaneous leiomyosarcoma of the face. 61
23717020 2013
43
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. 61
23293965 2013
44
Superficial paramucosal clear cell sarcoma of the soft parts resembling melanoma in a 13-year-old boy. 61
23228147 2013
45
Cutaneous leiomyosarcoma arising in a smallpox scar. 61
22799750 2012
46
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin. 61
22207443 2012
47
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. 61
22324176 2012
48
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. 61
22019008 2011
49
Primary cutaneous leiomysarcoma. 61
22345781 2011
50
Cutaneous leiomyosarcoma on the trunk. 61
22147043 2011

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 VIM MUC1 DES CALD1 ACTC1
2
Show member pathways
11.47 VIM GFAP DES
3 11.23 VIM S100B GFAP
4 10.99 VIM DES ACTC1
5
Show member pathways
10.97 VIM DES

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.86 VIM S100B GFAP FOXO4 FH DES
2 cytoskeleton GO:0005856 9.72 VIM GFAP DES CALD1 ACTC1
3 cytoplasm GO:0005737 9.61 VIM S100B MUC1 GFAP FOXO4 FH
4 intermediate filament GO:0005882 9.33 VIM GFAP DES
5 intermediate filament cytoskeleton GO:0045111 8.8 VIM GFAP DES

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte development GO:0014002 9.32 VIM GFAP
2 Bergmann glial cell differentiation GO:0060020 9.26 VIM GFAP
3 intermediate filament-based process GO:0045103 9.16 VIM GFAP
4 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
5 intermediate filament organization GO:0045109 8.8 VIM GFAP DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 VIM S100B GFAP FOXO4 DES
2 myosin binding GO:0017022 8.96 CALD1 ACTC1
3 structural constituent of cytoskeleton GO:0005200 8.8 VIM GFAP DES

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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