MCID: CTN012
MIFTS: 30

Cutaneous Leiomyosarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

MalaCards integrated aliases for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 15 74
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 51 C4484
UMLS 74 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and epithelioid leiomyosarcoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Signaling by ERBB4. Affiliated tissues include skin, smooth muscle and brain, and related phenotype is homeostasis/metabolism.

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 30.4 ACTC1 DES FH S100B
2 epithelioid leiomyosarcoma 30.0 ACTC1 DES
3 leiomyoma 29.4 ACTC1 DES FH
4 dermatofibrosarcoma protuberans 29.4 ACTC1 DES S100B
5 syringocystadenoma papilliferum 28.7 ACTC1 DES GFAP S100B
6 malignant giant cell tumor 10.1 ACTC1 S100B
7 malignant giant cell tumor of soft parts 10.1 ACTC1 S100B
8 myopericytoma 10.1 ACTC1 S100B
9 spiradenoma 10.1 ACTC1 S100B
10 myoma 10.1
11 ovarian benign neoplasm 10.1 DES FH
12 ovarian fibrothecoma 10.1 ACTC1 DES
13 fibroblastic rheumatism 10.1 ACTC1 DES
14 angiolipoma 10.1 ACTC1 DES
15 dendritic cell tumor 10.1 ACTC1 S100B
16 giant cell tumor 10.1 ACTC1 DES
17 malignant triton tumor 10.1 DES S100B
18 botryoid rhabdomyosarcoma 10.1 ACTC1 DES
19 spindle cell lipoma 10.1 ACTC1 DES
20 glomangioma 10.1 ACTC1 DES
21 myxofibrosarcoma 10.1 DES S100B
22 benign metastasizing leiomyoma 10.1 ACTC1 DES
23 polymorphous low-grade adenocarcinoma 10.1 ACTC1 S100B
24 non-langerhans-cell histiocytosis 10.0 ACTC1 DES
25 pulmonary vein stenosis 10.0 ACTC1 DES
26 juvenile xanthogranuloma 10.0 DES S100B
27 pleomorphic liposarcoma 10.0 DES S100B
28 perivascular epithelioid cell tumor 10.0 ACTC1 DES
29 congenital fibrosarcoma 10.0 ACTC1 DES
30 ischemic fasciitis 10.0 ACTC1 DES
31 fasciitis 10.0 ACTC1 DES
32 reticulum cell sarcoma 10.0 ACTC1 DES
33 pseudosarcomatous fibromatosis 10.0 ACTC1 DES
34 fibromatosis 10.0 ACTC1 DES
35 dedifferentiated liposarcoma 10.0 ACTC1 DES
36 glomus tumor 10.0 ACTC1 DES
37 embryonal sarcoma 10.0 DES S100B
38 smooth muscle tumor 10.0 ACTC1 DES
39 infantile myofibromatosis 10.0 ACTC1 DES
40 chondromyxoid fibroma 10.0 ACTC1 DES
41 rhabdoid tumor predisposition syndrome 1 10.0 ACTC1 DES
42 angiomyolipoma 10.0 ACTC1 DES
43 spindle cell carcinoma 10.0 ACTC1 DES
44 anaplastic ganglioglioma 10.0 ACTC1 GFAP
45 ganglioglioma 10.0 GFAP S100B
46 familial isolated dilated cardiomyopathy 10.0 ACTC1 DES
47 intracranial cysts 10.0 GFAP S100B
48 malignant peripheral nerve sheath tumor 9.9 ACTC1 S100B
49 gemistocytic astrocytoma 9.9 GFAP S100B
50 chordoid meningioma 9.9 GFAP S100B

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 ACTC1 DES FH GFAP S100B

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

42
Skin, Smooth Muscle, Brain, Lymph Node, Kidney, Cervix

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 84)
# Title Authors Year
1
Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study. ( 30932400 )
2019
2
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome: A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. ( 28475508 )
2018
3
Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation with Prognosis in 12 Patients. ( 29100621 )
2018
4
Cutaneous Leiomyosarcoma: On the Importance of Histologic Location. ( 29233527 )
2018
5
Cutaneous leiomyosarcoma on the face. ( 29723357 )
2018
6
Advanced Magnetic Resonance Imaging in the Evaluation of a Chronic Non-healing ulcer - A Case Report of Rare Primary Cutaneous Leiomyosarcoma. ( 30687652 )
2018
7
Cutaneous leiomyosarcoma on the trunk: An unusual presentation with an aggressive course - Case report and review of literature. ( 31068995 )
2018
8
Primary cutaneous vascular leiomyosarcoma: A rare subtype of leiomyosarcoma of the skin. ( 29740853 )
2018
9
Primary leiomyosarcoma of the skin: a comprehensive review on diagnosis and treatment. ( 30140957 )
2018
10
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. ( 28177971 )
2017
11
Cutaneous Leiomyosarcoma with Multiple Visceral Metastases in a Domestic Pigeon. ( 28665730 )
2017
12
Cutaneous Leiomyosarcoma of the Face. ( 28913324 )
2017
13
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of the fumarate hydratase gene. ( 25913776 )
2016
14
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. ( 26787636 )
2016
15
Recurrent cutaneous leiomyosarcoma of the inner thigh. ( 25900934 )
2015
16
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. ( 26276213 )
2015
17
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. ( 26516329 )
2015
18
Cutaneous leiomyosarcoma - Case report. ( 25408738 )
2014
19
Leiomyosarcoma of the skin: clinical, histopathologic, and prognostic factors that influence outcomes. ( 25174541 )
2014
20
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. ( 23293965 )
2013
21
Rapid growing superficial cutaneous leiomyosarcoma of the face. ( 23717020 )
2013
22
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. ( 23851868 )
2013
23
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. ( 23984230 )
2013
24
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. ( 24077407 )
2013
25
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. ( 22324176 )
2012
26
Cutaneous leiomyosarcoma arising in a smallpox scar. ( 22799750 )
2012
27
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. ( 19780873 )
2011
28
Superficial cutaneous leiomyosarcoma of the face: report of three cases. ( 21352334 )
2011
29
Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma". ( 21358302 )
2011
30
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. ( 21571171 )
2011
31
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. ( 22019008 )
2011
32
Cutaneous leiomyosarcoma on the trunk. ( 22147043 )
2011
33
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. ( 20102404 )
2010
34
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. ( 20534095 )
2010
35
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. ( 20579459 )
2010
36
Childhood cutaneous leiomyosarcoma. ( 19689533 )
2009
37
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. ( 19010751 )
2009
38
Cutaneous leiomyosarcoma developing on a pacemaker pocket. ( 19389092 )
2009
39
Cutaneous leiomyosarcoma in a pigeon. ( 18296669 )
2008
40
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. ( 18429649 )
2008
41
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. ( 18986479 )
2008
42
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. ( 17343592 )
2007
43
Cutaneous leiomyosarcoma: a tumor of the head and neck. ( 17451590 )
2007
44
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. ( 18416331 )
2007
45
Leiomyosarcoma of the skin with osteoclast-like giant cells: a case report. ( 18081931 )
2007
46
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? ( 16634920 )
2006
47
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. ( 16972948 )
2006
48
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. ( 16972950 )
2006
49
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. ( 14765271 )
2004
50
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. ( 15491456 )
2004

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 DES GFAP
2
Show member pathways
11.19 GFAP S100B
3 10.85 GFAP S100B
4 10.48 ACTC1 DES

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.96 ACTC1 GFAP
2 intermediate filament cytoskeleton GO:0045111 8.62 DES GFAP

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.16 GFAP S100B
2 muscle filament sliding GO:0030049 8.96 ACTC1 DES
3 intermediate filament organization GO:0045109 8.62 DES GFAP

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 DES GFAP

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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