MCID: CTN012
MIFTS: 27

Cutaneous Leiomyosarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

MalaCards integrated aliases for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 15 72
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 50 C4484
UMLS 72 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and epithelioid leiomyosarcoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include skin, smooth muscle and lymph node.

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 30.7 FH DES ACTC1
2 epithelioid leiomyosarcoma 30.1 DES ACTC1
3 smooth muscle tumor 29.7 DES ACTC1
4 dermatofibrosarcoma protuberans 29.5 DES ACTC1
5 leiomyoma 29.3 FH DES ACTC1
6 spindle cell sarcoma 29.2 MUC1 DES ACTC1
7 medulloblastoma 28.4 GFAP DES ACTC1
8 syringocystadenoma papilliferum 28.0 MUC1 GFAP DES ACTC1
9 mucinous ovarian cystadenoma 10.2 MUC1 FH
10 soft tissue sarcoma 10.2
11 adenofibroma 10.2 MUC1 ACTC1
12 spiradenoma 10.2 MUC1 ACTC1
13 ovarian benign neoplasm 10.2 FH DES
14 ovarian fibrothecoma 10.1 DES ACTC1
15 fibroblastic rheumatism 10.1 DES ACTC1
16 dendritic cell tumor 10.1 MUC1 ACTC1
17 angiolipoma 10.1 DES ACTC1
18 chickenpox 10.1 MUC1 ACTC1
19 spindle cell thymoma 10.1 MUC1 DES
20 botryoid rhabdomyosarcoma 10.1 DES ACTC1
21 glomangioma 10.1 DES ACTC1
22 spindle cell lipoma 10.1 DES ACTC1
23 benign metastasizing leiomyoma 10.1 DES ACTC1
24 polymorphous low-grade adenocarcinoma 10.1 MUC1 ACTC1
25 biphasic synovial sarcoma 10.1 MUC1 DES
26 pulmonary vein stenosis 10.1 DES ACTC1
27 non-langerhans-cell histiocytosis 10.1 DES ACTC1
28 desmoplastic small round cell tumor 10.1 MUC1 DES
29 pleomorphic liposarcoma 10.1 MUC1 DES
30 proximal spinal muscular atrophy 10.1 MUC1 DES
31 congenital fibrosarcoma 10.1 DES ACTC1
32 cutaneous fibrous histiocytoma 10.1 DES ACTC1
33 fibrous histiocytoma 10.1 DES ACTC1
34 extraskeletal ewing sarcoma 10.1 MUC1 DES
35 mesenchymal chondrosarcoma 10.1 MUC1 DES
36 dedifferentiated liposarcoma 10.0 DES ACTC1
37 plasmablastic lymphoma 10.0 MUC1 DES
38 pseudosarcomatous fibromatosis 10.0 DES ACTC1
39 fibromatosis 10.0 DES ACTC1
40 glomus tumor 10.0 DES ACTC1
41 infantile myofibromatosis 10.0 DES ACTC1
42 polycystic liver disease 1 with or without kidney cysts 10.0 MUC1 ACTC1
43 chondromyxoid fibroma 10.0 DES ACTC1
44 angiomyolipoma 10.0 DES ACTC1
45 retinoblastoma 10.0
46 basal cell carcinoma 10.0
47 familial retinoblastoma 10.0
48 malignant mesenchymoma 10.0
49 keloid disorder 10.0
50 rare tumor 10.0

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

41
Skin, Smooth Muscle, Lymph Node, Adipocyte

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 132)
# Title Authors PMID Year
1
Cutaneous Leiomyosarcoma: A SEER Database Analysis. 38
31306276 2019
2
Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study. 38
30932400 2019
3
Cutaneous Sarcomas. 38
30497679 2019
4
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment. 38
30409380 2019
5
Primary cutaneous vascular leiomyosarcoma: A rare subtype of leiomyosarcoma of the skin. 38
29740853 2018
6
Primary leiomyosarcoma of the skin: a comprehensive review on diagnosis and treatment. 38
30140957 2018
7
Advanced Magnetic Resonance Imaging in the Evaluation of a Chronic Non-healing ulcer - A Case Report of Rare Primary Cutaneous Leiomyosarcoma. 38
30687652 2018
8
Leiomyosarcoma of the head and neck: A 17-year single institution experience and review of the National Cancer Data Base. 38
29286183 2018
9
Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation with Prognosis in 12 Patients. 38
29100621 2018
10
Cutaneous Leiomyosarcoma: On the Importance of Histologic Location. 38
29233527 2018
11
Cutaneous leiomyosarcoma on the face. 38
29723357 2018
12
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome: A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. 38
28475508 2018
13
Cutaneous leiomyosarcoma on the trunk: An unusual presentation with an aggressive course - Case report and review of literature. 38
31068995 2018
14
Cutaneous Leiomyosarcoma with Multiple Visceral Metastases in a Domestic Pigeon. 38
28665730 2017
15
Cutaneous Leiomyosarcoma of the Face. 38
28913324 2017
16
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. 38
28177971 2017
17
Periorbital leiomyosarcoma treated by means of conventional surgery and frontal myocutaneous flap. 38
29267467 2017
18
Subcutaneous Leiomyosarcoma Metastasized to the Lymph Nodes Involved with Small Lymphocytic Lymphoma / Chronic Lymphocytic Leukemia. 38
28272651 2017
19
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of the fumarate hydratase gene. 38
25913776 2016
20
Incidence of mature adipocytic component within cutaneous smooth muscle neoplasms. 38
27404774 2016
21
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. 38
26787636 2016
22
S100A6 expression in cutaneous smooth muscle neoplasms. 38
26238340 2015
23
Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX. 38
26098709 2015
24
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. 38
26276213 2015
25
Recurrent cutaneous leiomyosarcoma of the inner thigh. 38
25900934 2015
26
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. 38
26516329 2015
27
[Cutaneous and subcutaneous leiomyosarcoma: report of two cases]. 38
25780967 2014
28
Leiomyosarcoma of the skin: clinical, histopathologic, and prognostic factors that influence outcomes. 38
25174541 2014
29
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. 38
25263848 2014
30
Cutaneous leiomyosarcoma - Case report. 38
25408738 2014
31
Leiomyosarcoma of the Face. 38
28913187 2014
32
Pleomorphic dermal neoplasms: a review. 38
24508694 2014
33
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. 38
24077407 2013
34
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. 38
23851868 2013
35
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. 38
23984230 2013
36
Rapid growing superficial cutaneous leiomyosarcoma of the face. 38
23717020 2013
37
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. 38
23293965 2013
38
Superficial paramucosal clear cell sarcoma of the soft parts resembling melanoma in a 13-year-old boy. 38
23228147 2013
39
Cutaneous leiomyosarcoma arising in a smallpox scar. 38
22799750 2012
40
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin. 38
22207443 2012
41
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. 38
22324176 2012
42
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. 38
22019008 2011
43
Primary cutaneous leiomysarcoma. 38
22345781 2011
44
Cutaneous leiomyosarcoma on the trunk. 38
22147043 2011
45
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. 38
21571171 2011
46
Superficial cutaneous leiomyosarcoma of the face: report of three cases. 38
21352334 2011
47
Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma". 38
21358302 2011
48
Sarcomas of the skin in the elderly. 38
21146736 2011
49
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. 38
19780873 2011
50
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. 38
20579459 2010

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 MUC1 DES ACTC1
2
Show member pathways
11.19 GFAP DES
3 10.81 DES ACTC1

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.46 MUC1 FH DES ACTC1
2 cell body GO:0044297 8.96 GFAP ACTC1
3 intermediate filament cytoskeleton GO:0045111 8.62 GFAP DES

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.96 DES ACTC1
2 intermediate filament organization GO:0045109 8.62 GFAP DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 GFAP DES

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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