MCID: CTN020
MIFTS: 18

Cutaneous Sclerosis

Categories: Rare diseases

Aliases & Classifications for Cutaneous Sclerosis

MalaCards integrated aliases for Cutaneous Sclerosis:

Name: Cutaneous Sclerosis 53

Classifications:



Summaries for Cutaneous Sclerosis

MalaCards based summary : Cutaneous Sclerosis is related to scleroderma, familial progressive and systemic scleroderma. The drugs rituximab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and lung.

Related Diseases for Cutaneous Sclerosis

Graphical network of the top 20 diseases related to Cutaneous Sclerosis:



Diseases related to Cutaneous Sclerosis

Symptoms & Phenotypes for Cutaneous Sclerosis

Drugs & Therapeutics for Cutaneous Sclerosis

Drugs for Cutaneous Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2 174722-31-7 10201696
2 Antibodies Phase 2
3 Immunologic Factors Phase 2
4 Antibodies, Monoclonal Phase 2
5 Protein Kinase Inhibitors Phase 2
6 Antineoplastic Agents, Immunological Phase 2
7 Imatinib Mesylate Phase 2 220127-57-1 123596
8 Immunoglobulins Phase 2
9 Antirheumatic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SCLERoderma et Adipose-DErived Stroma Cells Unknown status NCT02866552 Phase 2 Stromal Vascular fraction;Ringer lactate
2 A Randomized Phase II Study of Imatinib and Rituximab for Cutaneous Sclerosis After Allogeneic Hematopoietic Cell Transplantation Completed NCT01309997 Phase 2 imatinib mesylate
3 The Effectiveness of UVB Irradiation in the Treatment of Skin Conditions With Altered Dermal Matrix: An Open Pilot Study Completed NCT00129428 Phase 1, Phase 2
4 A Pilot Study of Imatinib in the Treatment of Refractory Systemic Sclerosis Completed NCT00506831 Phase 1, Phase 2 Imatinib mesylate
5 Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis : Controlled Clinical Trial With Efficacy Assessment Terminated NCT02558543 Phase 2 Stromal Vascular fraction;Ringer lactate
6 Multicentre, Placebo-Controlled, Multi-Dosis, Phase I Clinical Trial to Evaluate the Tolerability and Bioavailability of TGF β1 Inhibitor Peptide 144 After Topical Administration in Healthy Volunteers. Completed NCT00656825 Phase 1 P144 cream;P144 cream;P144 cream;Placebo
7 Longitudinal Study of Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplantation (HCT) Completed NCT01206309
8 The Effectiveness Of UVA1 Irradiation In The Treatment Of Skin Conditions With Altered Dermal Matrix: A Controlled, Cross-Over Study Completed NCT00476801
9 Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis Recruiting NCT03374618
10 The Effectiveness of UVA1 Irradiation in the Treatment of Skin Conditions With Altered Dermal Matrix: An Open Pilot Study Terminated NCT00476697

Search NIH Clinical Center for Cutaneous Sclerosis

Genetic Tests for Cutaneous Sclerosis

Anatomical Context for Cutaneous Sclerosis

MalaCards organs/tissues related to Cutaneous Sclerosis:

41
Skin, Neutrophil, Lung, Eye, B Cells, T Cells

Publications for Cutaneous Sclerosis

Articles related to Cutaneous Sclerosis:

(show top 50) (show all 140)
# Title Authors PMID Year
1
Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease. 38
30994873 2019
2
Systemic Sclerosis at an Intensive Care Unit: A Case Series and Literature Review. 38
29912771 2019
3
Cervical cutaneous sclerosis: the stomach is not far from the skin. 38
30653760 2019
4
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in limited cutaneous sclerosis: a rare disease combination. 38
30617191 2019
5
Pulmonary hypertension on systemic sclerosis-lupus erythematosus overlap syndrome. 38
30685083 2019
6
Favorable impact of extracorporeal photopheresis in acute and chronic graft versus host disease: Prospective single-center study. 38
30394564 2018
7
[Sclerodermatous changes revealing porphyria cutanea tarda]. 38
29804804 2018
8
Lower-limb Ulcers in Systemic Sclerosis: A Multicentre Retrospective Case-control Study. 38
29648670 2018
9
Systemic sclerosis: Current concepts of skin and systemic manifestations. 38
30047430 2018
10
Case of generalized morphea with the manifestation of diffuse systemic cutaneous sclerosis without sclerodactyly. 38
29215147 2018
11
First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study. 38
29214548 2018
12
Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review. 38
28712039 2017
13
Tocilizumab for the Treatment of SLC29A3 Mutation Positive PHID Syndrome. 38
29079714 2017
14
Scleroderma in hospital settings in Lomé: 50 cases. 38
29313516 2017
15
Successful treatment of infliximab in a patient with scleroderma: a case report. 38
28562527 2017
16
UVA1 for diffuse cutaneous systemic sclerosis in a Fitzpatrick skin type VI patient: outcomes in the modified Rodnan skin score. 38
28375193 2017
17
[Macrovascular complications of systemic sclerosis: Prospective descriptive Doppler ultrasound study in 20 patients]. 38
27174391 2016
18
Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice. 38
26884373 2016
19
[Atypical scleromyxedema with a granulomatous histological pattern and delayed sclerosis]. 38
26969478 2016
20
Late Acute and Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation. 38
26541363 2016
21
Diagnosis and Management of Systemic Sclerosis: A Practical Approach. 38
26659258 2016
22
Paclitaxel-induced diffuse cutaneous sclerosis: a case with associated esophageal dysmotility, Raynaud's phenomenon, and myositis. 38
25266415 2016
23
A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation. 38
26378033 2016
24
Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review. 38
25626632 2015
25
Rituximab in the treatment of patients with systemic sclerosis. Our experience and review of the literature. 38
26209905 2015
26
Localized scleroderma: clinical spectrum and therapeutic update. 38
25672301 2015
27
Sclerosing disorders of the skin: an overview with focus on histopathological features. 38
25243394 2014
28
Prospective study to evaluate the clinical and radiological outcome of patients with scleroderma of the face. 38
23791631 2013
29
Progressive systemic sclerosis in a child. 38
24082203 2013
30
Paraneoplastic scleroderma-like tissue reactions in the setting of an underlying plasma cell dyscrasia: a report of 10 cases. 38
23669187 2013
31
Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. 38
23547053 2013
32
Immunohistochemical studies of the kynurenine pathway in morphea. 38
24385714 2013
33
[Special features of systemic sclerosis in men]. 38
22987380 2012
34
[Huge aspergilloma developed within a zone of scleroderma-related pulmonary fibrosis]. 38
22305135 2012
35
Red blood cell alterations in systemic sclerosis: a pilot study. 38
22814239 2012
36
Pesticide-induced scleroderma and early intensive immunosuppressive treatment. 38
22315935 2012
37
Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma. 38
22911870 2012
38
[A rare case of huge aspergilloma developed within a lesion of pulmonary fibrosis secondary with a systemic scleroderma in an immunocompetent patient in Madagascar]. 38
21698483 2011
39
Oral involvement of chronic graft-versus-host disease in hematopoietic stem cell transplant recipients. 38
22313917 2011
40
[Complaints, needs of patients with systemic sclerosis: a better understanding for a better care]. 38
21392865 2011
41
46, XX SRY-positive male syndrome presenting with primary hypogonadism in the setting of scleroderma. 38
20841307 2011
42
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. 38
21266028 2011
43
Cutaneous sclerosis: a previously undescribed manifestation of sclerosing mesenteritis. 38
20855700 2010
44
Nickel-induced allergy and contact dermatitis: does it induce autoimmunity and cutaneous sclerosis? An experimental study in Brown Norway rats. 38
19784841 2010
45
Taxane-induced morphea in a patient with CREST syndrome. 38
25386245 2010
46
[A cutaneous thickening case...]. 38
20518147 2010
47
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. 38
19714649 2009
48
Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. 38
19714619 2009
49
[Efficacy of intravenous immunoglobulin in Arndt-Gottron scleromyxedema]. 38
19361699 2009
50
[Erasmus syndrome: case report]. 38
19306779 2009

Variations for Cutaneous Sclerosis

Expression for Cutaneous Sclerosis

Search GEO for disease gene expression data for Cutaneous Sclerosis.

Pathways for Cutaneous Sclerosis

GO Terms for Cutaneous Sclerosis

Sources for Cutaneous Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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