MCID: CTN001
MIFTS: 21

Cutaneous Solitary Mastocytoma

Categories: Blood diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Solitary Mastocytoma

MalaCards integrated aliases for Cutaneous Solitary Mastocytoma:

Name: Cutaneous Solitary Mastocytoma 12 15
Solitary Mastocytoma of Skin 12
Solitary Mastocytoma 12
Skin Mastocytoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3666
UMLS 71 C0343115

Summaries for Cutaneous Solitary Mastocytoma

MalaCards based summary : Cutaneous Solitary Mastocytoma, also known as solitary mastocytoma of skin, is related to extracutaneous mastocytoma and mastocytosis. An important gene associated with Cutaneous Solitary Mastocytoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are NF-kappaB Signaling and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include skin.

Related Diseases for Cutaneous Solitary Mastocytoma

Diseases related to Cutaneous Solitary Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 extracutaneous mastocytoma 31.2 KITLG KIT CD2
2 mastocytosis 30.6 KITLG KIT CD2
3 dowling-degos disease 1 30.4 KITLG KIT
4 mast cell neoplasm 30.3 SERPINA3 KITLG KIT CMA1 CD2
5 systemic mastocytosis 30.1 KITLG KIT CD2
6 mastocytosis, cutaneous 29.7 KITLG KIT CMA1 CD2
7 cutaneous mastocytoma 12.0
8 urticaria 10.4
9 fibrous histiocytoma 10.3 SERPINA3 KIT
10 type c thymoma 10.3 SERPINA3 KIT
11 breast malignant phyllodes tumor 10.3 SERPINA3 KIT
12 embryonal sarcoma 10.3 SERPINA3 KIT
13 tenosynovial giant cell tumor 10.3 SERPINA3 KIT
14 malignant spindle cell melanoma 10.3 SERPINA3 KIT
15 heart cancer 10.3 SERPINA3 KIT
16 fibrosarcoma of bone 10.3 SERPINA3 KIT
17 pleomorphic liposarcoma 10.2 SERPINA3 KIT
18 adenosarcoma 10.2 SERPINA3 KIT
19 amelanotic melanoma 10.2 SERPINA3 KIT
20 mixed cell type cancer 10.2 SERPINA3 KIT
21 hemangiopericytoma, malignant 10.2 SERPINA3 KIT
22 mesenchymal cell neoplasm 10.2 SERPINA3 KIT
23 dysgerminoma 10.2 KITLG KIT
24 dysgerminoma of ovary 10.2 KITLG KIT
25 cardiovascular cancer 10.2 SERPINA3 KIT
26 vascular cancer 10.2 SERPINA3 KIT
27 synovium cancer 10.2 SERPINA3 KIT
28 smooth muscle tumor 10.2 SERPINA3 KIT
29 tonsil cancer 10.2 SERPINA3 KIT
30 waardenburg syndrome, type 4b 10.2 KITLG KIT
31 lipomatosis, multiple 10.2 SERPINA3 KIT
32 well-differentiated liposarcoma 10.2 SERPINA3 KIT
33 oropharynx cancer 10.2 SERPINA3 KIT
34 salivary gland disease 10.2 SERPINA3 KIT
35 cystadenoma 10.2 SERPINA3 KIT
36 lethal midline granuloma 10.2 SERPINA3 CD2
37 myxofibrosarcoma 10.2 SERPINA3 KIT
38 mast-cell leukemia 10.2 KITLG KIT
39 skeletal muscle cancer 10.2 SERPINA3 KIT
40 muscle cancer 10.1 SERPINA3 KIT
41 oligospermia 10.1 KITLG KIT
42 intestinal obstruction 10.1 SERPINA3 KIT
43 germ cell and embryonal cancer 10.1 SERPINA3 KIT
44 neurilemmoma 10.1 SERPINA3 KIT
45 testicular germ cell tumor 10.1 KITLG KIT
46 prolidase deficiency 10.1
47 angioedema 10.1
48 hepatitis b 10.1
49 skin disease 10.1
50 granuloma annulare 10.1

Graphical network of the top 20 diseases related to Cutaneous Solitary Mastocytoma:



Diseases related to Cutaneous Solitary Mastocytoma

Symptoms & Phenotypes for Cutaneous Solitary Mastocytoma

Drugs & Therapeutics for Cutaneous Solitary Mastocytoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Active, not recruiting NCT02761473

Search NIH Clinical Center for Cutaneous Solitary Mastocytoma

Genetic Tests for Cutaneous Solitary Mastocytoma

Anatomical Context for Cutaneous Solitary Mastocytoma

MalaCards organs/tissues related to Cutaneous Solitary Mastocytoma:

40
Skin

Publications for Cutaneous Solitary Mastocytoma

Articles related to Cutaneous Solitary Mastocytoma:

# Title Authors PMID Year
1
Solitary mastocytoma with massive eosinophilic infiltration. 61
7526356 1994

Variations for Cutaneous Solitary Mastocytoma

Expression for Cutaneous Solitary Mastocytoma

Search GEO for disease gene expression data for Cutaneous Solitary Mastocytoma.

Pathways for Cutaneous Solitary Mastocytoma

Pathways related to Cutaneous Solitary Mastocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.09 KITLG KIT CD2
2
Show member pathways
11.82 KITLG KIT CLEC11A
3 11.2 KITLG KIT CD2
4 11.05 KITLG KIT
5 10.93 KITLG KIT
6 10.79 KITLG KIT CD2
7 10.46 KITLG KIT CLEC11A CD2
8 10.36 KITLG KIT

GO Terms for Cutaneous Solitary Mastocytoma

Cellular components related to Cutaneous Solitary Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.43 KIT CLEC2A CD2
2 extracellular region GO:0005576 9.43 TPSD1 SERPINA3 KITLG CMA1 CLEC11A CD2
3 cytoplasmic side of plasma membrane GO:0009898 9.16 KIT CD2
4 extracellular space GO:0005615 9.1 TPSD1 SERPINA3 KITLG KIT CMA1 CLEC11A

Biological processes related to Cutaneous Solitary Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.26 KITLG KIT
2 ovarian follicle development GO:0001541 9.16 KITLG KIT
3 embryonic hemopoiesis GO:0035162 8.96 KITLG KIT
4 ectopic germ cell programmed cell death GO:0035234 8.62 KITLG KIT

Sources for Cutaneous Solitary Mastocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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