MCID: CYN003
MIFTS: 24

Cyanide Poisoning

Categories: Rare diseases

Aliases & Classifications for Cyanide Poisoning

MalaCards integrated aliases for Cyanide Poisoning:

Name: Cyanide Poisoning 58

Classifications:



External Ids:

ICD10 via Orphanet 33 T65.0
Orphanet 58 ORPHA466670

Summaries for Cyanide Poisoning

MalaCards based summary : Cyanide Poisoning is related to metabolic acidosis and lactic acidosis. An important gene associated with Cyanide Poisoning is HBG2 (Hemoglobin Subunit Gamma 2). The drugs Methylprednisolone and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin, and related phenotype is Increased shRNA abundance.

Wikipedia : 74 Cyanide poisoning is poisoning that results from exposure to a number of forms of cyanide. Early... more...

Related Diseases for Cyanide Poisoning

Diseases related to Cyanide Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 metabolic acidosis 10.7
2 lactic acidosis 10.6
3 ocular motor apraxia 10.5
4 methemoglobinemia 10.4
5 cardiac arrest 10.3
6 anoxia 10.3
7 cyanosis, transient neonatal 10.2
8 atrioventricular block 10.2
9 respiratory failure 10.1
10 urticaria 10.1
11 dystonia 10.1
12 neuropathy 10.1
13 encephalopathy 10.1
14 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
15 3-methylglutaconic aciduria, type iii 10.0
16 yemenite deaf-blind hypopigmentation syndrome 10.0
17 branchiootic syndrome 1 10.0
18 ventricular fibrillation, paroxysmal familial, 1 10.0
19 foodborne botulism 10.0
20 exanthem 10.0
21 apraxia 10.0
22 pulmonary edema 10.0
23 visual epilepsy 10.0
24 cholestasis 10.0
25 polyneuropathy 10.0
26 anuria 10.0
27 testicular cancer 10.0
28 acute kidney failure 10.0
29 benign ependymoma 10.0
30 pancreatitis 10.0
31 cellular ependymoma 10.0
32 kidney disease 10.0
33 diabetes insipidus 10.0
34 hypoglycemia 10.0
35 48,xyyy 10.0
36 brain injury 10.0
37 hypoxia 10.0
38 seizure disorder 10.0
39 syncope 10.0
40 sulfhemoglobinemia 9.2 MPST HBG2

Graphical network of the top 20 diseases related to Cyanide Poisoning:



Diseases related to Cyanide Poisoning

Symptoms & Phenotypes for Cyanide Poisoning

GenomeRNAi Phenotypes related to Cyanide Poisoning according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.62 HBG2 MPST

Drugs & Therapeutics for Cyanide Poisoning

Drugs for Cyanide Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
2
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
3
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
5 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
8 Antidotes Phase 2
9 Protective Agents Phase 2
10 Antioxidants Phase 2
11 Antitubercular Agents Phase 2
12 Chelating Agents Phase 2
13 Anti-Infective Agents Phase 2
14 Anti-Bacterial Agents Phase 2
15
Hydrogen sulfide Phase 2 7783-06-4 402
16 Pharmaceutical Solutions Phase 2
17 Methylprednisolone Acetate Phase 2
18 sodium thiosulfate Phase 2
19 Calcium, Dietary
20
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Groningen Intervention Study for the Preservation of Cardiac Function With Sodium Thiosulfate After ST-segment Elevation Myocardial Infarction Recruiting NCT02899364 Phase 2 Sodium thiosulfate;Sodium chloride 0.9%
2 Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff Recruiting NCT04251832 Phase 2 Sodium Thiosulfate
3 Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study Suspended NCT03582800 Phase 2 STS
4 Using an Electronic Nose to Predict Gastrointestinal Consequences of Pelvic Radiotherapy Unknown status NCT02649491
5 European Survey: Risk of Cyanide Poisoning in Smoke Inhalation, Symptoms, Key Treatment and Outcome (RISK) Completed NCT01386788
6 Is it Possible to Treat Cyanide Poisoning With HBO? Completed NCT00399100
7 The Effect of Sodium Thiosulfate Treatment on Vascular Calcification in End Stage Renal Failure Patients Completed NCT00568399 sodium thiosulfate
8 Treatment of Ectopic Calcification / Ossification With Sodium Thiosulfate (CATSSO) Recruiting NCT03979378
9 Cyanide Poisoning in Fire Victims Withdrawn NCT00280579
10 Hydroxycobalamin and Rural Emergency Medical Services Cyanide Exposure Patients: A Cost Analysis Withdrawn NCT01656616 Cyanide antidote administration

Search NIH Clinical Center for Cyanide Poisoning

Genetic Tests for Cyanide Poisoning

Anatomical Context for Cyanide Poisoning

MalaCards organs/tissues related to Cyanide Poisoning:

40
Heart, Brain, Skin, Testes, Kidney, Liver, Skeletal Muscle

Publications for Cyanide Poisoning

Articles related to Cyanide Poisoning:

(show top 50) (show all 730)
# Title Authors PMID Year
1
Long-Term Neuropsychiatric Sequelae in a Survivor of Cyanide Toxicity Patient With Arterialization. 61
32509487 2020
2
Smoke inhalation injury in a 2-year-old domestic fire victim. 61
32192813 2020
3
Inhaler intoxications developed during autopsy of the corpse due to cyanide intake: Case series. 61
32276813 2020
4
Toxic inhalational injury. 61
32161078 2020
5
Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning. 61
31389254 2020
6
Carbon Monoxide and Cyanide Intoxication: An Association to Remember. 61
32035501 2020
7
Diagnosis of cyanide poisoning using an automated, field-portable sensor for rapid analysis of blood cyanide concentrations. 61
31948575 2020
8
Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. 61
31008657 2020
9
Carbon monoxide poisoning. 61
32176957 2020
10
Vitamin B12 for the treatment of vasoplegia in cardiac surgery and liver transplantation: a narrative review of cases and potential biochemical mechanisms. 61
31346957 2019
11
Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. 61
31870461 2019
12
Antidotes in Poisoning. 61
32020997 2019
13
Cyanide concentrations in blood and tissues of fire victims. 61
31711010 2019
14
From Fixing Photos to Fixing Cyanide Poisoning: Herschel's "Hypo" or Sodium Thiosulfate. 61
31613861 2019
15
Case Report of Lethal Toxin Lurking in an Edible Plant. 61
31904202 2019
16
Behavioural and physiological assessments of dimethyl trisulfide treatment for acute oral sodium cyanide poisoning. 61
30843331 2019
17
Bacterial Cheaters Evade Punishment by Cyanide. 61
31357168 2019
18
Determination of free cyano-cobinamide in swine and rabbit plasma by liquid chromatography tandem mass spectrometry. 61
31185415 2019
19
Biodegradable Therapeutic Microneedle Patch for Rapid Antihypertensive Treatment. 61
31382742 2019
20
Fatality from potassium gold cyanide poisoning. 61
31350229 2019
21
Efficacy assessment of co-treated alpha-ketoglutarate and N-acetyl cysteine against the subchronic toxicity of cyanide in rats. 61
31244408 2019
22
En Route Resuscitation - Utilization of CCATT to Transport and Stabilize Critically Injured and Unstable Casualties. 61
30535030 2019
23
Outbreak of Cyanide Poisoning Caused by Consumption of Cassava Flour - Kasese District, Uganda, September 2017. 61
30946738 2019
24
A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges. 61
30539383 2019
25
Cyanide Toxicity!! Colour of Blood Says It All. 61
31097895 2019
26
Rationally designed molecules for resurgence of cyanide mitigated cytochrome c oxidase activity. 61
30391853 2019
27
Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning. 61
31355359 2019
28
Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide. 61
30855115 2019
29
A Case of Hydroxocobalamin-Induced False Blood Leak Alarm on Dialysis Machine. 61
31701774 2019
30
An inhalational swine model for the characterization of physiological effects and toxicological profile associated with cyanide poisoning. 61
30757927 2018
31
Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication. 61
30208987 2018
32
Challenges in the diagnosis of acute cyanide poisoning. 61
29417853 2018
33
Determinants of Lactic Acidosis in Acute Cyanide Poisonings. 61
29543597 2018
34
Cyanide poisoning is a possible cause of cardiac arrest among fire victims, and empiric antidote treatment may improve outcomes. 61
29395761 2018
35
Alpha ketoglutarate nanoparticles: A potentially effective treatment for cyanide poisoning. 61
28629719 2018
36
DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice. 61
28922956 2018
37
Neuronal nitric oxide inhibition attenuates the protective effect of HBO2 during cyanide poisoning. 61
30028920 2018
38
Methylene blue counteracts cyanide cardiotoxicity: cellular mechanisms. 61
29420146 2018
39
Cyanide poisoning in Thailand before and after establishment of the National Antidote Project. 61
28871819 2018
40
Carbon Monoxide and Cyanide Poisoning in the Burned Pregnant Patient: An Indication for Hyperbaric Oxygen Therapy. 61
29461288 2018
41
Modulating Electrocatalysis on Graphene Heterostructures: Physically Impermeable Yet Electronically Transparent Electrodes. 61
29444401 2018
42
Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. 61
29879736 2018
43
Lactate blood measurement in acute cyanide poisoning: effect of preanalytical delay and hydroxocobalamin uses as treatment. 61
29243660 2018
44
[Socioemotional disorders in children living in Konzo-affected areas, an epidemic paralytic disease associated with cyanide poisoning from food in sub-Saharan Africa]. 61
31037178 2018
45
[A case report of acute severe hydrogen cyanide poisoning]. 61
29495184 2018
46
Inhaled cyanide poisoning as a vital sign in a room fire victim. 61
29128126 2017
47
Hemolysis index to detect degree of hydroxocobalamin interference with common laboratory tests. 61
27859624 2017
48
Live reef fish displaying physiological evidence of cyanide poisoning are still traded in the EU marine aquarium industry. 61
28747697 2017
49
Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. 61
28041825 2017
50
Methylene blue modulates functional connectivity in the human brain. 61
26961091 2017

Variations for Cyanide Poisoning

Expression for Cyanide Poisoning

Search GEO for disease gene expression data for Cyanide Poisoning.

Pathways for Cyanide Poisoning

GO Terms for Cyanide Poisoning

Sources for Cyanide Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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