TNCY
MCID: CYN002
MIFTS: 45

Cyanosis, Transient Neonatal (TNCY)

Categories: Blood diseases, Fetal diseases, Genetic diseases

Aliases & Classifications for Cyanosis, Transient Neonatal

MalaCards integrated aliases for Cyanosis, Transient Neonatal:

Name: Cyanosis, Transient Neonatal 56 29 13 6 39 71
Cyanosis 43 32
Tncy 56 73
Cyanosis Transient Neonatal 73

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant

Miscellaneous:
onset at birth
spontaneously resolves by 5 to 6 months of age


HPO:

31
cyanosis, transient neonatal:
Inheritance autosomal dominant inheritance
Onset and clinical course congenital onset


Classifications:



External Ids:

OMIM 56 613977
MeSH 43 D003490
ICD10 32 R23.0
MedGen 41 C3151421
UMLS 71 C3151421

Summaries for Cyanosis, Transient Neonatal

OMIM : 56 Neonatal cyanosis is characterized by symptoms in the fetus and neonate that gradually abate by 5 to 6 months of age. The disorder is caused by a defect in the fetal hemoglobin chain, which causes reduced affinity for oxygen due to steric inhibition of oxygen binding and/or due to increased oxidation of the fetal hemoglobin molecule to methemoglobin (Hb FM), which has decreased oxygen-binding capacity. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain (HBB; 141900) is produced and replaces the fetal gamma-globin chain (summary by Crowley et al., 2011). (613977)

MalaCards based summary : Cyanosis, Transient Neonatal, also known as cyanosis, is related to cyanosis and hepatic disease and rombo syndrome, and has symptoms including cyanosis An important gene associated with Cyanosis, Transient Neonatal is HBG2 (Hemoglobin Subunit Gamma 2). The drugs Clindamycin and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and liver, and related phenotypes are hepatomegaly and anemia

UniProtKB/Swiss-Prot : 73 Cyanosis transient neonatal: A disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain.

Related Diseases for Cyanosis, Transient Neonatal

Diseases related to Cyanosis, Transient Neonatal via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 266, show less)
# Related Disease Score Top Affiliating Genes
1 cyanosis and hepatic disease 12.4
2 rombo syndrome 12.0
3 congenital methemoglobinemia 11.7
4 methemoglobinemia due to deficiency of methemoglobin reductase 11.7
5 tetralogy of fallot 11.6
6 hemoglobinopathy toms river 11.6
7 methemoglobinemia, beta-globin type 11.5
8 methemoglobinemia 11.5
9 heart disease 11.4
10 cor triatriatum dexter 11.4
11 eisenmenger syndrome 11.4
12 dextro-looped transposition of the great arteries 11.4
13 heterotaxy 11.4
14 sulfhemoglobinemia 11.4
15 tricuspid atresia 11.3
16 pulmonary venous return anomaly 11.3
17 buerger disease 11.3
18 alveolar capillary dysplasia with misalignment of pulmonary veins 11.3
19 central hypoventilation syndrome, congenital 11.2
20 methemoglobinemia, beta type 11.2
21 methemoglobinemia, alpha type 11.2
22 arterial calcification of infancy 11.2
23 pulmonary atresia with intact ventricular septum 11.2
24 seizures, benign familial infantile, 1 11.2
25 acrocephalopolysyndactyly type iii 11.0
26 emphysema, congenital lobar 11.0
27 laryngomalacia 11.0
28 neuropathy, hereditary sensory and autonomic, type iii 11.0
29 methemoglobinemia and ambiguous genitalia 11.0
30 obesity-hypoventilation syndrome 11.0
31 glycogen storage disease of heart, lethal congenital 11.0
32 lymphangiectasia, pulmonary, congenital 11.0
33 right ventricular hypoplasia, isolated 11.0
34 hydrocephalus with cerebellar agenesis 11.0
35 hypomagnesemia 1, intestinal 11.0
36 pulmonary alveolar proteinosis, acquired 11.0
37 pitt-hopkins syndrome 11.0
38 reynolds syndrome 11.0
39 episodic pain syndrome, familial, 1 11.0
40 chronic mountain sickness 11.0
41 hypoplastic right heart syndrome 11.0
42 esophageal atresia/tracheoesophageal fistula 11.0
43 silicosis 11.0
44 severe pre-eclampsia 11.0
45 blue toe syndrome 11.0
46 congenital myasthenic syndrome 11.0
47 pulmonary venoocclusive disease 11.0
48 congenital laryngeal palsy 11.0
49 infantile apnea 11.0
50 tracheal agenesis 11.0
51 critical congenital heart disease 11.0
52 univentricular heart 11.0
53 heart septal defect 10.7
54 atrial heart septal defect 10.7
55 pulmonary hypertension 10.5
56 patent foramen ovale 10.4
57 liver cirrhosis 10.4
58 pulmonary arteriovenous fistulas 10.4
59 arteriovenous malformation 10.4
60 ventricular septal defect 10.4
61 polycythemia 10.4
62 pulmonary arteriovenous malformation 10.4
63 patent ductus arteriosus 1 10.3
64 hepatopulmonary syndrome 10.3
65 cor triatriatum 10.3
66 single ventricular heart 10.3
67 tricuspid valve insufficiency 10.3
68 liver disease 10.3
69 congestive heart failure 10.3
70 pulmonary hypertension, primary, 1 10.2
71 pulmonary valve stenosis 10.2
72 mitral valve stenosis 10.2
73 lung disease 10.2
74 pulmonary embolism 10.2
75 anoxia 10.2
76 interatrial communication 10.2
77 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.2
78 deficiency anemia 10.2
79 telangiectasis 10.2
80 hemoglobinopathy 10.2
81 pneumonia 10.2
82 portal hypertension 10.1
83 double outlet right ventricle 10.1
84 dextrocardia 10.1
85 aneurysm 10.1
86 acquired methemoglobinemia 10.1
87 argyria 10.1
88 ebstein anomaly 10.0
89 sudden infant death syndrome 10.0
90 cardiac arrest 10.0
91 hemopericardium 10.0
92 hereditary hemorrhagic telangiectasia 10.0
93 aortic aneurysm 10.0
94 tricuspid valve stenosis 10.0
95 bronchitis 10.0
96 situs inversus 10.0
97 hypoplastic left heart syndrome 10.0
98 aortic arch interruption 10.0
99 atrial septal defect coronary sinus 10.0
100 carcinoid syndrome 10.0
101 noonan syndrome 1 10.0
102 pulmonary atresia with ventricular septal defect 10.0
103 dowling-degos disease 1 10.0
104 schistosoma mansoni infection, susceptibility/ 10.0
105 scleroderma, familial progressive 10.0
106 methemoglobin reductase deficiency 10.0
107 dermatitis herpetiformis, familial 10.0
108 atrioventricular septal defect 10.0
109 aortic aneurysm, familial thoracic 1 10.0
110 alpha-1-antitrypsin deficiency 10.0
111 rheumatic heart disease 10.0
112 endocarditis 10.0
113 microcephaly 10.0
114 respiratory failure 10.0
115 pulmonary edema 10.0
116 cardiac tamponade 10.0
117 pericardial effusion 10.0
118 persistent fetal circulation syndrome 10.0
119 schistosomiasis 10.0
120 urticaria 10.0
121 pericarditis 10.0
122 cerebral palsy 10.0
123 dermatitis 10.0
124 hemolytic anemia 10.0
125 dermatitis herpetiformis 10.0
126 hypereosinophilic syndrome 10.0
127 48,xyyy 10.0
128 double discordia 10.0
129 pseudo-turner syndrome 10.0
130 raynaud phenomenon 10.0
131 headache 10.0
132 hypertonia 10.0
133 hypoxia 10.0
134 syncope 10.0
135 congenital portosystemic shunt 10.0
136 levocardia 10.0
137 persistent eustachian valve 10.0
138 amyotrophic lateral sclerosis 1 9.8
139 atrial standstill 1 9.8
140 gastroesophageal reflux 9.8
141 attention deficit-hyperactivity disorder 9.8
142 lipomatosis, multiple 9.8
143 systemic lupus erythematosus 9.8
144 pulmonary hemosiderosis 9.8
145 raynaud disease 9.8
146 sarcoidosis 1 9.8
147 triiodothyronine receptor auxiliary protein 9.8
148 down syndrome 9.8
149 varicose veins 9.8
150 vitiligo-associated multiple autoimmune disease susceptibility 6 9.8
151 wolff-parkinson-white syndrome 9.8
152 chiari malformation type ii 9.8
153 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
154 leprosy 3 9.8
155 pulmonic stenosis 9.8
156 reticulum cell sarcoma 9.8
157 anemia, nonspherocytic hemolytic, due to g6pd deficiency 9.8
158 stroke, ischemic 9.8
159 branchiootic syndrome 1 9.8
160 dermatitis, atopic 9.8
161 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8
162 pulmonary disease, chronic obstructive 9.8
163 nasopharyngeal carcinoma 9.8
164 anxiety 9.8
165 angina pectoris 9.8
166 arrhythmogenic right ventricular cardiomyopathy 9.8
167 visceral heterotaxy 9.8
168 metabolic acidosis 9.8
169 limb ischemia 9.8
170 fibroma 9.8
171 inflammatory myofibroblastic tumor 9.8
172 infective endocarditis 9.8
173 pain agnosia 9.8
174 scoliosis 9.8
175 adenoid hypertrophy 9.8
176 umbilical hernia 9.8
177 thrombosis 9.8
178 postural orthostatic tachycardia syndrome 9.8
179 pleomorphic lipoma 9.8
180 meningoencephalitis 9.8
181 sarcoma 9.8
182 plethora of newborn 9.8
183 disseminated intravascular coagulation 9.8
184 adult respiratory distress syndrome 9.8
185 gestational diabetes 9.8
186 hepatorenal syndrome 9.8
187 visual epilepsy 9.8
188 allergic hypersensitivity disease 9.8
189 hemosiderosis 9.8
190 pyloric stenosis 9.8
191 diarrhea 9.8
192 tuberous sclerosis 9.8
193 cholestasis 9.8
194 biliary atresia 9.8
195 toxic shock syndrome 9.8
196 capillary leak syndrome 9.8
197 candidiasis 9.8
198 thrombocytopenia 9.8
199 pneumothorax 9.8
200 factitious disorder 9.8
201 vascular disease 9.8
202 hepatitis c 9.8
203 lutembacher's syndrome 9.8
204 autoimmune hepatitis 9.8
205 intestinal perforation 9.8
206 hepatitis 9.8
207 lateral sclerosis 9.8
208 arteriosclerosis 9.8
209 post-thrombotic syndrome 9.8
210 dyskeratosis congenita 9.8
211 skin atrophy 9.8
212 pulmonary tuberculosis 9.8
213 adenocarcinoma 9.8
214 glioblastoma multiforme 9.8
215 interstitial lung disease 9.8
216 ischemia 9.8
217 gastric adenocarcinoma 9.8
218 pulmonary fibrosis 9.8
219 gastritis 9.8
220 intracranial thrombosis 9.8
221 spindle cell sarcoma 9.8
222 hypotrichosis 9.8
223 nutritional deficiency disease 9.8
224 dystonia 9.8
225 aortic valve insufficiency 9.8
226 connective tissue disease 9.8
227 cerebral angioma 9.8
228 achenbach syndrome 9.8
229 myocarditis 9.8
230 cataract 9.8
231 influenza 9.8
232 myeloid leukemia 9.8
233 lupus erythematosus 9.8
234 erythromelalgia 9.8
235 cleft lip 9.8
236 intracranial hypertension 9.8
237 primary ciliary dyskinesia 9.8
238 hydrocele 9.8
239 47,xyy 9.8
240 cardiac rupture 9.8
241 chiari malformation 9.8
242 chromosomal triplication 9.8
243 complete atrioventricular canal 9.8
244 congenital extrahepatic portosystemic shunt 9.8
245 congenital hepatic fibrosis 9.8
246 congenitally corrected transposition of the great arteries 9.8
247 hansen's disease 9.8
248 neonatal stroke 9.8
249 osteochondroma 9.8
250 undifferentiated connective tissue disease 9.8
251 weber syndrome 9.8
252 angiomatosis 9.8
253 brain injury 9.8
254 dysautonomia 9.8
255 hypotonia 9.8
256 myotonia 9.8
257 seizure disorder 9.8
258 posttransplant acute limbic encephalitis 9.8
259 rare cardiac tumor 9.8
260 congenital systemic arteriovenous fistula 9.8
261 inferior vena cava interruption without azygos continuation 9.8
262 azygos continuation of the inferior vena cava 9.8
263 atrial septal aneurysm 9.8
264 polyendocrinopathy 9.8
265 primary adrenal insufficiency 9.8
266 fetal hemoglobin quantitative trait locus 1 9.2 LOC106099065 HBG2

Graphical network of the top 20 diseases related to Cyanosis, Transient Neonatal:



Diseases related to Cyanosis, Transient Neonatal

Symptoms & Phenotypes for Cyanosis, Transient Neonatal

Human phenotypes related to Cyanosis, Transient Neonatal:

31 (showing 6, show less)
# Description HPO Frequency HPO Source Accession
1 hepatomegaly 31 occasional (7.5%) HP:0002240
2 anemia 31 occasional (7.5%) HP:0001903
3 jaundice 31 occasional (7.5%) HP:0000952
4 reticulocytosis 31 occasional (7.5%) HP:0001923
5 cyanosis 31 HP:0000961
6 methemoglobinemia 31 HP:0012119

Symptoms via clinical synopsis from OMIM:

56
Skin Nails Hair Skin:
cyanosis
jaundice (in some)

Abdomen Liver:
hepatomegaly (in some)

Laboratory Abnormalities:
methemoglobinemia

Hematology:
decreased oxygen-binding capacity of hemoglobin
decreased hemoglobin oxygen saturation
anemia (in some)
reticulocytosis (in some)

Clinical features from OMIM:

613977

UMLS symptoms related to Cyanosis, Transient Neonatal:


cyanosis

Drugs & Therapeutics for Cyanosis, Transient Neonatal

Drugs for Cyanosis, Transient Neonatal (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 164, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Sodium citrate Approved, Investigational Phase 4 68-04-2
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Caffeine Approved Phase 4 58-08-2 2519
5
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
6
Ceftriaxone Approved Phase 4 73384-59-5 5361919 5479530
7
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
12
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
13
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
14 Gentamicins Phase 4
15 Clindamycin phosphate Phase 4
16 Clindamycin palmitate Phase 4
17 Phosphodiesterase Inhibitors Phase 4
18 Citrate Phase 4
19 Anti-Bacterial Agents Phase 4
20 Anti-Infective Agents Phase 4
21 Central Nervous System Stimulants Phase 4
22 Caffeine citrate Phase 4
23 Antibiotics, Antitubercular Phase 4
24 Fat Emulsions, Intravenous Phase 4
25 Soy Bean Phase 4
26 Amoxicillin-Potassium Clavulanate Combination Phase 4
27 beta-Lactamase Inhibitors Phase 4
28 Micronutrients Phase 4
29 Trace Elements Phase 4
30 Pharmaceutical Solutions Phase 4
31 Antiemetics Phase 4
32 Gastrointestinal Agents Phase 4
33 Dopamine Agents Phase 4
34 Dopamine Antagonists Phase 4
35 Anesthetics Phase 4
36 Adrenergic beta-Agonists Phase 4
37 Respiratory System Agents Phase 4
38 Adrenergic Agents Phase 4
39 Anti-Asthmatic Agents Phase 4
40 Albuterol Phase 4
41 Adrenergic Agonists Phase 4
42 Neurotransmitter Agents Phase 4
43 Tocolytic Agents Phase 4
44 Bronchodilator Agents Phase 4
45 Anti-Inflammatory Agents Phase 4
46 Anesthetics, General Phase 4
47 Antioxidants Phase 4
48 Platelet Aggregation Inhibitors Phase 4
49 Hypnotics and Sedatives Phase 4
50 Anesthetics, Intravenous Phase 4
51 Anesthetics, Inhalation Phase 4
52
Enalapril Approved, Vet_approved Phase 3 75847-73-3 40466924 5362032
53
Enalaprilat Approved Phase 3 76420-72-9 6917719
54
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
55 Fasudil Investigational Phase 3 103745-39-7
56 Angiotensin-Converting Enzyme Inhibitors Phase 3
57 Antihypertensive Agents Phase 3
58 Phosphodiesterase 5 Inhibitors Phase 3
59 Vasodilator Agents Phase 3
60 Endothelin Receptor Antagonists Phase 3
61 Sildenafil Citrate Phase 3 171599-83-0
62 Protein Kinase Inhibitors Phase 3
63 Calcium, Dietary Phase 3
64 calcium channel blockers Phase 3
65
Calcium Nutraceutical Phase 3 7440-70-2 271
66
Nitric Oxide Approved Phase 2 10102-43-9 145068
67
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
68
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 27284 23925
69
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
70
Vitamin D3 Approved, Nutraceutical Phase 1, Phase 2 67-97-0 5280795 6221
71
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 1406-16-2
72 Molgramostim Investigational Phase 2 99283-10-0
73 omega-N-Methylarginine Phase 2
74 Protective Agents Phase 1, Phase 2
75 Hematinics Phase 2
76 Epoetin alfa Phase 2 113427-24-0
77 Iron Supplement Phase 2
78 Vitamins Phase 1, Phase 2
79 Calciferol Phase 1, Phase 2
80 Immunologic Factors Phase 2
81
Primaquine Approved Phase 1 90-34-6 4908
82
Methadone Approved Phase 1 76-99-3 4095
83
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
84
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
85
Budesonide Approved Phase 1 51333-22-3 63006 5281004
86 Vaccines Phase 1
87 Heptavalent Pneumococcal Conjugate Vaccine Phase 1
88 Antiparasitic Agents Phase 1
89 Antiprotozoal Agents Phase 1
90 Antimalarials Phase 1
91
protease inhibitors Phase 1
92 HIV Protease Inhibitors Phase 1
93 Hormones Phase 1
94 Antineoplastic Agents, Hormonal Phase 1
95 Hormone Antagonists Phase 1
96 glucocorticoids Phase 1
97 BB 1101 Phase 1
98
Iloprost Approved, Investigational 78919-13-8 6443959
99
Ipratropium Approved, Experimental 60205-81-4, 22254-24-6 43232 657309
100
Tranylcypromine Approved, Investigational 155-09-9 441233
101
Tranexamic Acid Approved 1197-18-8 5526
102
Dobutamine Approved 34368-04-2 36811
103
tannic acid Approved 1401-55-4
104
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
105
Prednisone Approved, Vet_approved 53-03-2 5865
106
Fluticasone Approved, Experimental 90566-53-3 62924
107
Lidocaine Approved, Vet_approved 137-58-6 3676
108
Prilocaine Approved 721-50-6 4906
109
Epinephrine Approved, Vet_approved 51-43-4 5816
110
Racepinephrine Approved 329-65-7 838
111
Nifedipine Approved Early Phase 1 21829-25-4 4485
112
Norepinephrine Approved 51-41-2 439260
113
Apixaban Approved 503612-47-3 10182969
114
Ampicillin Approved, Vet_approved 69-53-4 6249
115
Turmeric Approved, Experimental, Investigational
116
Enoxaparin Approved 9005-49-6 772
117
Phenylephrine Approved 59-42-7 6041
118
Oxymetazoline Approved, Investigational 1491-59-4 4636
119 Kava Approved, Investigational, Nutraceutical 9000-38-8
120
Imidacloprid Vet_approved 105827-78-9 86418
121 Hemostatics
122 Antifibrinolytic Agents
123 Anti-Anxiety Agents
124 Antidepressive Agents
125 Psychotropic Drugs
126 Monoamine Oxidase Inhibitors
127 Coagulants
128 Calamus
129 Sodium Channel Blockers
130 Adrenergic alpha-Agonists
131 Anti-Arrhythmia Agents
132 Epinephryl borate
133 Anesthetics, Local
134 Diuretics, Potassium Sparing
135 Mydriatics
136 Sympathomimetics
137 Anti-Allergic Agents
138 Chelating Agents
139 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
140 Vasoactive intestinal peptide 40077-57-4
141 neurokinin A
142
Substance P 33507-63-0 44359816
143 Immunoglobulins
144 Vitamin B Complex
145 Antibodies
146 Antibodies, Antinuclear
147 Fluorides
148 Antithrombins
149 Antithrombin III
150 Serine Proteinase Inhibitors
151 Factor Xa Inhibitors
152 Chinese Salvia
153 Astragalus
154 Ginkgo
155 Fibrinolytic Agents
156 Anticoagulants
157 Vasoconstrictor Agents
158 Bromides
159 Cholinergic Agents
160 Muscarinic Antagonists
161 Cholinergic Antagonists
162
Glycopyrrolate 596-51-0 3494
163 Anticonvulsants
164
Serine Investigational, Nutraceutical 56-45-1 5951

Interventional clinical trials:

(showing 100, show less)
# Name Status NCT ID Phase Drugs
1 A Randomized Clinical Trial Between Clindamycin Once and Thrice a Day in Septic Abortion. Unknown status NCT02309346 Phase 4 Clindamycin
2 Magnetic Resonance Imaging and Neurodevelopmental Outcomes in Preterm Infants Following Administration of High-Dose Caffeine - A Pilot Study Completed NCT00809055 Phase 4 Caffeine citrate
3 The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis: a Randomized Pilot Controlled Trial Completed NCT03275090 Phase 4 Smoflipid ®
4 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
5 Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children Completed NCT00968370 Phase 4
6 Use of Metoclopramide for the Prevention of Gastroesophageal Reflux in Premature Infants Followed in an Outpatient Kangaroo Mother Care Clinic Before 40 Weeks of Gestational Age: A Randomized Controlled Trial Recruiting NCT02907632 Phase 4 Metoclopramide;Placebo
7 A Prospective Study on the Use of Hypertonic Saline Inhalation in Acute Bronchiolitis in Children Not yet recruiting NCT03880903 Phase 4 normal saline and salbutamol;hypertonic saline and salbutamol;Hypertonic saline
8 The Anti-inflammatory and Anti-oxidant Effects of Propofol and Sevoflurane in Children With Cyanotic Congenital Heart Disease Not yet recruiting NCT04125550 Phase 4 Propofol;Sevoflurane
9 Trial of ACE Inhibition in Infants With Single Ventricle (A Trial Conducted by the Pediatric Heart Network) Completed NCT00113087 Phase 3 Enalapril;Placebo
10 Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers Syndrome Completed NCT00303004 Phase 3 Bosentan and Sildenafil
11 NEWBORN VENTILATION IN THE DELIVERY ROOM: CAN IT BE IMPROVED WITH A T-PIECE RESUSCITATOR? Multicenter Cross-over Cluster Randomized Controlled Trial Completed NCT00443118 Phase 3
12 Efficacy, Tolerability and Biology of a Rho-kinase Inhibitor (Fasudil) in the Treatment of Raynaud's Phenomenon Completed NCT00498615 Phase 3 Fasudil
13 " Ilomedin for Treatment of Septic Shock With Persistent Microperfusion Defects ", a Double-blind, Randomized Controlled Trial:The I-MICRO Trial Recruiting NCT03788837 Phase 3 Ilomedin;NaCl
14 Safety and Feasibility of Controlled Tidal Volume Resuscitation of Preterm Infants ≤ 28 Weeks’ Gestation: A Randomized Controlled Pilot Study Terminated NCT00157989 Phase 3
15 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Injection for Diabetes Secondary Peripheral Arterial Disease Unknown status NCT02287831 Phase 1, Phase 2
16 Solar Powered Oxygen Delivery: An Open-label Non-inferiority Comparison to Standard Oxygen Delivery Using Oxygen Cylinders Completed NCT02100865 Phase 2
17 Determination of Nitrite as a Source of Bioactive Nitric Oxide in Human Subjects Completed NCT00048477 Phase 2 L-NMMA and Sodium Nitrite
18 Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis Completed NCT03295162 Phase 1, Phase 2 Melatonin 10 mg
19 Erythropoietin to Prevent Unnecessary Transfusions In Patients With Cyanotic Congenital Heart Disease - A Prospective Randomized Control Trial Recruiting NCT02564796 Phase 2 Epoetin Alfa and Iron
20 Randomized Controlled Trial of Vitamin D Supplementation on Improvement of Pneumonic Children at Tertiary Pediatric Hospital in Egypt Active, not recruiting NCT04244474 Phase 1, Phase 2 A single one ml injection
21 RIGENERA 2.0 (Recupero Dall'Infarto Miocardico Con G-CSF E Nuovi Esempi di Rigenerazione Avanzata) Project: "The Combined Effect of Subcutaneous Granulocyte - Colony Stimulating Factor and Myocardial Contrast Echocardiography With Intravenous Infusion of Sulphur Hexafluoride on Post-infarction Left Ventricular Function" Suspended NCT02502747 Phase 2 rhu G-CSF;optimal standard of care
22 Impact of Early Enteral Feeding on Splanchnic Blood Flow After Surgery for Critical Heart Disease in the Newborn Terminated NCT00919945 Phase 2
23 Feasibility and Efficacy Of Negative Pressure Ventilation in Fontan populatioN: Cardiovascular Flow Assessment by Magnetic Resonance Imaging Completed NCT03251742 Phase 1
24 Dynamics of the Immune Response in Children to the 23-valent Pneumococcal Capsular Polysaccharide Vaccine (Pneumovax) Completed NCT03460730 Phase 1
25 A Study of the Pharmacokinetics of Primaquine in Lactating Women and Breastfed Infants for the Radical Treatment of Uncomplicated Maternal P. Vivax Completed NCT01780753 Phase 1 Primaquine
26 Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy. Not yet recruiting NCT03436225 Phase 1 Dexamethasone orally.;Dexamethasone parenteral.;Inhaled nebulized Budesonide.;Inhaled nebulized salbutamol.
27 Diagnosis of Ascites in Infants and Children Unknown status NCT03341221
28 Pulse Oximetry With Clinical Observation to Screen for Lung Disease in Neonates Unknown status NCT02533583
29 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
30 Aerobic Exercise Increases Phosphate Removal During Hemodialysis Unknown status NCT01912417
31 Long-term Effects on Pulmonary Function in Post- Fontan Operation Unknown status NCT01413308
32 Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart Disease (Eisenmenger Physiology): Safety, Tolerability, Clinical, and Hemodynamic Effect. Unknown status NCT01383083
33 Detection of Pleural Effusion by Internal Thoracic Impedance Method Unknown status NCT01601444
34 Fenestrated Vs Non Fenestrated Extra-Cardiac Total Cavo-pulmonary Connection in Patients With Standard Preoperative Risk Profiles, A Prospective Randomized Study Unknown status NCT03503032
35 Effect of Assisted Exercise on Musculoskeletal System and Growth in Preterm Infants Unknown status NCT03354988
36 Salbutamol in the Pediatric Emergencies: Nebulization Estimated Via AerogeN or Jet Unknown status NCT03042065
37 Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery: Implication of Preoperative Cyanosis Completed NCT01311310
38 Accuracy Assessment of 7 Clinical Indicators in Newborn Screening for Congenital Heart Disease Completed NCT01665261
39 Tranexamic Acid Reduces Blood Loss in Pediatric Cardiac Surgery Completed NCT00994994 Tranexamic Acid
40 Laryngomalacia Exposed Completed NCT01042223
41 Retrospective Review of Neonates With Neurological Complications Following Cardiac Surgery Completed NCT00366561
42 ST2, a Novel Biomarker for Cardiac Remodeling in Adults With Congenital Heart Disease Completed NCT01774890
43 Neuromuscular Electrical Stimulation Improves Exercise Tolerance in Patients With Advanced Heart Failure on Continuous Dobutamine Use - A Randomized Controlled Trial Completed NCT02668419
44 The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension Completed NCT01313832
45 Different Modalities for Evaluation of Fetal Cardiac Function in Pregnant Women With Rheumatic Heart Disease (RHD) Patients Completed NCT03095937
46 Sleep-disordered Breathing in Eisenmenger Syndrome Completed NCT02614417
47 Use of Bubble CPAP Compared to Nasal Prong Oxygen or Humidified High Flow in Children Under Five With Severe Pneumonia and Hypoxaemia: a Randomized Trial Completed NCT01396759
48 Efficacy of Aquatic Physiotherapy in Stress Level and Muscle Tone of Children Between 3 and 24 Months With Microcephaly by Zika Virus Congenital Syndrome Completed NCT03330600
49 The Effects of Endotracheal Tube Fixation Methods on Hemodynamic Parameters During Endotracheal Suction in Cardiovascular Surgery Intensive Care Patients Completed NCT04199039
50 The Effect of Vest Type Dynamic Elastomeric Fabric Orthosis (DEFO) on Sitting Balance and Gross Manuel Dexterity in Children With Bilateral Cerebral Palsy: A Feasibility and Randomized, Single-blinded, Pilot Study Completed NCT03191552
51 A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP) Completed NCT02506062
52 Intestinal Function in Neonates With Complex Congenital Heart Disease Completed NCT01475357
53 Assessment of Clinical Competence of Medical Students: a Comparison of High-fidelity Simulation, Serious Game and Multiple-choice Questions Completed NCT03884114
54 Safety of Airway Clearance Combined With Bronchodilator and Hypertonic Saline in Non-hospitalized Infants With Acute Viral Bronchiolitis Completed NCT03835858
55 Neurodevelopmental Outcomes and Postoperative Hemodynamics in Children With Hypoplastic Left Heart Syndrome Completed NCT00464100
56 IndiaCLEN Multicentric Trial of Home Versus Hospital Oral Amoxicillin for Management of Severe Pneumonia in Children Completed NCT01386840
57 Urine and Serum Biomarkers for Early Detection of Acute Kidney Injury Following Cardiopulmonary Bypass Surgery for Congenital Heart Disease in Children and Adults: A Pilot Study Completed NCT01531985
58 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine Completed NCT01402869 4% prilocaine plain;2% Lidocaine with 1:100,000 epinephrine
59 Immediate Effects and Safety of High-frequency Chest Wall Oscillation Compared to Airway Clearance Techniques in Non-hospitalized Infants With Acute Viral Bronchiolitis Completed NCT03835936
60 Orogastric Intubation With Dental Fixation Versus Nasogastric Intubation: a Cross-over Randomized Trial Completed NCT03670238
61 Effects of Compression in Mixed Ulcers Completed NCT02838251
62 Assessment of Autonomic Function and Cardiovascular Response to Exercise Testing in Parkinson's Disease Patients Completed NCT03156400
63 Effect of Chronic Changes in Heart Rate on Congestive Heart Failure Completed NCT00389649
64 PCR Technique of a Commercial Test and Blood Culture to Early Detect Sepsis in NICU Completed NCT03884894
65 Pre-warming With Thermal Gown Prevents Maternal Hypothermia in Elective Cesarean Section Completed NCT02091466
66 "Color Doppler Ultrasound Comparison of Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud: A Randomized, Double-blind, Placebo-controlled Pilot Study" Completed NCT03027674 Early Phase 1 10% nifedipine cream;5% sildenafil cream
67 Assessment of Immediate Adverse Reactions in Children Under 2 Years of Age Following Administration of Gadoteric Acid (Gd-DOTA or Dotarem) Completed NCT02609919 Gadoteric Acid
68 Air Cleaners for Children and Adolescents With Asthma and Dog Allergy Completed NCT00220753
69 Use of Oral 40% Destrogel to Prevent Hypoglycaemia in Late-term Births and SGA or LGA Term Newborns Completed NCT04185766
70 Pediatric Remote Ischemic Pre-conditioning Prior to Complex Cardiac Surgery Completed NCT01739088
71 An Investigation Into The Potential Roles Of Vasoactive Intestinal Peptide And Substance P In The Pathophysiology Of Plastic Bronchitis And Protein Losing Enteropathy In Children With Palliated Single Ventricle Physiology Completed NCT01563757
72 RaynAUT - Thermography and the Autonomic Nervous System in Raynaud's Phenomenon - Investigation of the Autonomic Nervous System in Patients With Raynaud's Phenomenon, Glaucoma, and Autonomic Neuropathy. Completed NCT03094910
73 Evaluation of an Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438
74 Randomized Controlled Trial (RCT) in Children With Severe Pneumonia Completed NCT00455468
75 Pilot Project on Clinical Tolerance to a Live Attenuated Vaccine Against Influenza (Flumist®) in the Context of Influenza Vaccination in a Population Allergic to Eggs. Completed NCT02142491
76 Maternal and Neonatal Outcome in Severe Preeclamptic Patients Recruiting NCT04126122
77 Factors Associated With Normal Exercise Capacity in Patients With Single Ventricle: the Multicenter Cross-sectional Study Recruiting NCT04026542
78 A Prospective Study on the Safety and Efficacy of Apixaban for the PReventiOn of ThromboEmbolism in Adults With Congenital HearΤ Disease and Atrial ARrhythmias Recruiting NCT03854149 Apixaban
79 The Maternal and Neonatal Impact of Early Versus Delayed Umbilical Cord Clamping Among Pregnant Severe Preeclampsia Patients Delivered by Cesarean Section Recruiting NCT04193345
80 Efficacy of Two Doses of Parenteral Amoxicillin Plus Single Dose Gentamicin Compared to Four Doses of Parenteral Ampicillin Plus Single Dose Gentamicin in Managing Children Hospitalized With WHO Classified Severe Pneumonia: a RCT Recruiting NCT03369093 Amoxicillin
81 Effects of Hydrotherapy in Premature Infants With Bronchopulmonary Dysplasia During Hospitalization: a Randomized Clinical Trial Recruiting NCT03538977
82 Effect of Solar Powered Oxygen Delivery on Childhood Mortality in Uganda: A Cluster-Randomized Trial Recruiting NCT03851783
83 Effects of a N95 Respirator vs Cloth Mask on Exercise Capacity During Treadmill Exercise. Recruiting NCT04415879
84 4DFlow Magnetic Resonance Imaging in Patients With Pulmonary Hypertension Associated With Congenital Heart Disease Recruiting NCT03928002
85 Comparison Of The Fast Pharmaco-invasive Strategy With The Standard Pharmaco-invasive Strategy In Patients With ST Elevation Myocardial Infarction Stratified By The Forearm Approach: Randomized Clinical Trial Recruiting NCT04300582
86 The Effectiveness of an Empirical Chinese Medicine Formulation for Idiopathic Pulmonary Fibrosis: an Open Label Clinical Trial Recruiting NCT03274544
87 Implementation Research for Introducing Sustainable Uptake of cKMC Intervention Package in Rural Pakistan. A Community-based Cluster Randomized Controlled Trial. Recruiting NCT03545204
88 Multicenter Randomized Controlled Trial: Evaluation of the Effects of Respiratory Physiotherapy, Placebo-controlled, in Infants With Moderate Acute Bronchiolitis Recruiting NCT03753802
89 Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial Active, not recruiting NCT02600260 Enoxaparin
90 Ventilator Weaning Outcome Between Non-invasive Neural Adjusted Ventilator Assist and Nasal Continuous Positive Airway Pressure (or Intermittent Mandatory Ventilation) Modes in Premature Neonates Enrolling by invitation NCT04118400
91 Iron Profile in Patients With Congenital Cyanotic Heart Disease Not yet recruiting NCT04104061
92 Impact of Neurophysiological Facilitation of Respiration in Preterm Neonates Admitted in Level II Neonatal Intensive Care Unit: A Randomized Controlled Trail Not yet recruiting NCT04019886
93 Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia Not yet recruiting NCT04401345 Glycopyrrolate 0.2 MG/ML;Normal saline
94 Primary Spontaneous Pneumothorax and Different Types of Surgical Management Not yet recruiting NCT03804385
95 A Retrospective Review of Postoperative Management of Cyanosis Following Bidirectional Glenn Operation Terminated NCT00327886
96 Optimal Timing for Repair of Right-to-Left Shunt Lesions Terminated NCT00268099
97 Proposal for Retrospective Review of Descending Aortic Flow Reversal in Total Anomalous Pulmonary Venous Connection Terminated NCT00486070
98 Evaluation of Professional Practices on the Management of Cardiogenic Pulmonary Edema (RENAU-OAP) Terminated NCT03148847
99 Randomised Controlled Trial to Study the Effect of Nasal Continuous Positive Airway Pressure (NCPAP) Cycling on Successful Weaning When Compared With Nasal Continuous Positive Airway Pressure (NCPAP) in Premature Infants of 25-28 Weeks Gestation Terminated NCT02114112
100 Ultrasound to Predict Steal-Syndrome After Arteriovenous-Fistula Creation (UPSAC - Trial) Withdrawn NCT01468506

Search NIH Clinical Center for Cyanosis, Transient Neonatal

Cochrane evidence based reviews: cyanosis

Genetic Tests for Cyanosis, Transient Neonatal

Genetic tests related to Cyanosis, Transient Neonatal:

# Genetic test Affiliating Genes
1 Cyanosis, Transient Neonatal 29 HBG2

Anatomical Context for Cyanosis, Transient Neonatal

MalaCards organs/tissues related to Cyanosis, Transient Neonatal:

40
Heart, Lung, Liver, Testes, Skin, Brain, Kidney

Publications for Cyanosis, Transient Neonatal

Articles related to Cyanosis, Transient Neonatal:

(showing 5763, show less)
# Title Authors PMID Year
1
A hemoglobin variant associated with neonatal cyanosis and anemia. 56 6 61
21561349 2011
2
Neonatal cyanosis due to a novel fetal hemoglobin: Hb F-Circleville [Ggamma63(E7)His-->Leu, CAT>CTT]. 6 56 61
19065339 2008
3
A new case of Hb F-M-Osaka [G gamma 63(E7)His-->Tyr] showed only benign neonatal cyanosis. 56 61 6
8811323 1996
4
Hemoglobin F-Cincinnati, alpha 2G gamma 2 41(C7) Phe-->Ser in a newborn with cyanosis. 56 6 61
7741137 1995
5
Mutant fetal hemoglobin causing cyanosis in a newborn. 61 56 6
2470017 1989
6
Hb F-M-Osaka [Ggamma63(E7)His --> tyr] in a newborn from southwest France. 56 6
12603090 2003
7
Hemoglobin FM-Fort Ripley: another lesson from the neonate. 6 56
2470018 1989
8
Hb F-M-Osaka or alpha 2G gamma 2(63)(E7)His----Tyr in a Caucasian male infant. 56 6
2483933 1989
9
A new abnormal fetal hemoglobin, Hb FM-Osaka (alpha 2 gamma 2 63His replaced by Tyr). 56 6
6158500 1980
10
Fractional exhaled nitric oxide in adult congenital heart disease. 61
32407788 2020
11
Exercise testing for assessment of heart failure in adults with congenital heart disease. 61
31686282 2020
12
IDDCA syndrome in a Chinese infant due to GNB5 biallelic mutations. 61
32203251 2020
13
Heart failure in the adult Ebstein patient. 61
32472521 2020
14
[Cardiogenic shock]. 61
32095880 2020
15
Early hours in the development of high-altitude pulmonary edema: time course and mechanisms. 61
32213112 2020
16
Successful occlusion of a large pulmonary arterio-venous fistula with Amplatzer septal occluder in a 16-year-old cyanotic boy. 61
32547663 2020
17
Bridging bronchus (pseudocarina) and left pulmonary artery sling: A case report and literature review. 61
32534300 2020
18
The many faces and outcomes of pulmonary vein stenosis in early childhood. 61
32506838 2020
19
EF hand-like motif mutations of Nav1.4 C-terminus cause myotonic syndrome by impairing fast inactivation. 61
32129495 2020
20
Adult congenital heart disease and the COVID-19 pandemic. 61
32522822 2020
21
Interstitial pneumonia as the initial presentation in an infant with a novel mutation of CD40 ligand-associated X-linked hyper-IgM syndrome: A case report. 61
32541472 2020
22
MAFB modulates the maturation of lymphatic vascular networks in mice. 61
32525258 2020
23
Primary repair of transposition of the great arteries with an interrupted aortic arch: a case report and literature review. 61
32527284 2020
24
Tricuspid atresia: Where are we now? 61
32484582 2020
25
Epidemiological and clinical characteristics of severe hand-foot-and-mouth disease (HFMD) among children: a 6-year population-based study. 61
32460823 2020
26
Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes. 61
32390527 2020
27
Prevalence and Prognostic Association of a Clinical Diagnosis of Depression in Adult Congenital Heart Disease: Results of the Boston Adult Congenital Heart Disease Biobank. 61
32342722 2020
28
Assessing the Incidence of Symptomatic Respiratory Syncytial Virus Illness Within a Prospective Birth Cohort in Managua, Nicaragua. 61
31257406 2020
29
The Peacock study: feasibility of the dynamic characterisation of the paediatric hypothalamic-pituitary-adrenal function during and after cardiac surgery. 61
32450805 2020
30
Clinical and surgical aspects of congenital lobar over-inflation: a single center retrospective study. 61
32429981 2020
31
Percutaneous Atrial Septal Defect Closure in Adult Ebstein's Anomaly with Exertional Hypoxemia. 61
32418968 2020
32
Whole bowel irrigation in dapsone intoxication with persistent methemoglobinemia: A case report. 61
32507475 2020
33
Clinical Spectrum and Long-term Outcome of 183 Cases of Ebstein's Anomaly, Experience of Mexican Population. 61
32253047 2020
34
A summary of second systemic pulmonary shunt for congenital heart disease with pulmonary hypoxemia. 61
32410655 2020
35
Image to Fit the Clinical Picture: Point-of-care Ultrasound Assessment of Ebstein's Anomaly in Peru. 61
32426677 2020
36
Acquired methemoglobinemia presenting to the pediatric emergency department: a clinical challenge. 61
32396060 2020
37
Systematic Review of Methemoglobinemia in Acetaminophen Poisoning. 61
32428237 2020
38
Coronavirus: a clinical update of Covid-19. 61
32428144 2020
39
Pulmonary hypertension in late-onset Methylmalonic Aciduria and Homocystinemia: a case report. 61
32443968 2020
40
Congenital systemic venous drainage obstruction: A case report. 61
32403179 2020
41
Chronic active Epstein-Barr virus infection with intrapulmonary shunting: A case report. 61
31983614 2020
42
Foreign Body Aspiration Presenting as Pneumothorax in a Child. 61
32550077 2020
43
Development of Eosinophilic Temporal Arteritis and Digital Ischemia in a Patient with Hypereosinophilic Syndrome. 61
32101832 2020
44
New type of corona virus induced acute otitis media in adult. 61
32336572 2020
45
Supraglottoplasty in Neonates under One Month of Age. 61
31875410 2020
46
Successful rescue using tracheal intubation cannula for severe central airway stenosis after tracheotomy: A CARE compliant case report. 61
32481279 2020
47
Severe acute dried gangrene in COVID-19 infection: a case report. 61
32495913 2020
48
Approach to Cyanotic Congenit