MCID: CYC008
MIFTS: 49

Cyclic Vomiting Syndrome

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Cyclic Vomiting Syndrome

MalaCards integrated aliases for Cyclic Vomiting Syndrome:

Name: Cyclic Vomiting Syndrome 57 76 53 25
Cyclical Vomiting Syndrome 25 6 73
Cvs 57 53 25
Abdominal Migraine 25 73
Familial Cyclic Vomiting Syndrome 53
Cyclical Vomiting 25
Periodic Vomiting 25

Characteristics:

OMIM:

57
Inheritance:
multifactorial
mitochondrial

Miscellaneous:
mean age at onset 5 years
mean age at resolution of symptoms 10 years
cyclic vomiting syndrome plus (cvs+) is characterized by additional neuromuscular and/or visceral organ manifestations (as indicated above)


HPO:

32
cyclic vomiting syndrome:
Inheritance multifactorial inheritance mitochondrial inheritance


Classifications:



Summaries for Cyclic Vomiting Syndrome

NIH Rare Diseases : 53 Cyclic vomiting syndrome (CVS) is a condition characterized by recurrent, prolonged episodes of severe nausea and vomiting. Episodes of vomiting may last hours or days. Other signs and symptoms during episodes may include intense sweating, paleness, weakness and fatigue, abdominal pain, diarrhea, fever, dizziness, and headache. Most people with CVS are symptom-free in between episodes, but some people have milder symptoms. The condition can begin at any age, but it most often begins in childhood. A subset of people with CVS also have neurologic or neuromuscular disorders; the condition in these cases is referred to as "CVS plus." The underlying cause of CVS is unknown. Data suggest there is a strong genetic component for CVS in children, involving changes (mutations) in mitochondrial DNA. Researchers believe that the condition primarily affects the brain, causing abnormalities in how the brain and gut interact. Many people with CVS report "triggers" for episodes, such as excitement, stress, infections, eating certain foods, and menstruation. People with a family history of migraines may be more likely to develop CVS. Treatment strategies for controlling symptoms may include avoiding triggers, medications to prevent or relieve nausea, tricyclic antidepressants, anti-migraine medications, and supplements called coenzyme Q-10 and L-carnitine. While some people with CVS outgrow the condition within a few years, others continue to have episodes through adulthood. Children who outgrow CVS may go on to develop migraines. 

MalaCards based summary : Cyclic Vomiting Syndrome, also known as cyclical vomiting syndrome, is related to anxiety and dihydropyrimidinase deficiency, and has symptoms including abdominal pain, lethargy and nausea. An important gene associated with Cyclic Vomiting Syndrome is MT-TL1 (Mitochondrially Encoded TRNA Leucine 1 (UUA/G)), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Interleukin-4 and 13 signaling. The drugs Dopamine and Haloperidol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are microcephaly and hearing impairment

Genetics Home Reference : 25 Cyclic vomiting syndrome is a disorder that causes recurrent episodes of nausea, vomiting, and tiredness (lethargy). This condition is diagnosed most often in young children, but it can affect people of any age.

Wikipedia : 76 Cyclic vomiting syndrome (US English) or cyclical vomiting syndrome (UK English) (CVS) is a chronic... more...

Description from OMIM: 500007

Related Diseases for Cyclic Vomiting Syndrome

Diseases related to Cyclic Vomiting Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 anxiety 29.3 CNR1 HTR3A
2 dihydropyrimidinase deficiency 11.0
3 neu-laxova syndrome 1 10.9
4 anophthalmos with limb anomalies 10.9
5 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.9
6 trisomy 2 mosaicism 10.9
7 chronic pain 10.3 CNR1 OPRM1
8 withdrawal disorder 10.2 CNR1 OPRM1
9 amnestic disorder 10.2 CNR1 HTR3A
10 influenza 10.2
11 pain agnosia 10.2 CNR1 OPRM1
12 haemophilus influenzae 10.2
13 fibromyalgia 10.2 HTR3A IL6
14 agnosia 10.2 CNR1 OPRM1
15 drug dependence 10.2 CNR1 OPRM1
16 constipation 10.1 HTR3A OPRM1
17 uremic pruritus 10.1 CNR1 IL6
18 specific developmental disorder 10.1 CNR1 OPRM1
19 headache 10.1
20 aging 10.0
21 mitochondrial disorders 10.0
22 japanese encephalitis 10.0
23 encephalitis 10.0
24 disease of mental health 10.0 CNR1 OPRM1
25 overnutrition 10.0 CNR1 IL6
26 neuropathy 9.9
27 rabies 9.9
28 albinism 9.9
29 pertussis 9.8 IL6 OPRM1
30 psychotic disorder 9.8 CNR1 HTR3A
31 alcohol dependence 9.8 CNR1 HTR3A OPRM1
32 diabetes mellitus, noninsulin-dependent 9.8
33 otitis media 9.8
34 familial adenomatous polyposis 9.8
35 nasopharyngitis 9.8
36 adenoma 9.8
37 gastroesophageal reflux 9.8
38 renal cell carcinoma, nonpapillary 9.8
39 autoimmune hepatitis 9.8
40 hepatitis 9.8
41 sinusitis 9.8
42 autonomic neuropathy 9.8
43 esophagitis 9.8
44 guillain-barre syndrome 9.8
45 epilepsy 9.8
46 wernicke encephalopathy 9.8
47 sensory peripheral neuropathy 9.8
48 food allergy 9.8
49 ischemia 9.8
50 cerebritis 9.8

Graphical network of the top 20 diseases related to Cyclic Vomiting Syndrome:



Diseases related to Cyclic Vomiting Syndrome

Symptoms & Phenotypes for Cyclic Vomiting Syndrome

Symptoms via clinical synopsis from OMIM:

57
Skin Nails Hair Skin:
pallor

Neurologic Central Nervous System:
lethargy
vomiting, episodic
rapid onset
occurs most often during the night or early morning
peak frequency of vomiting every 10 to 15 minutes
more
Head And Neck Head:
microcephaly (in patients with 'cvs-plus,' cvs+)

Head And Neck Eyes:
strabismus (cvs+)

Muscle Soft Tissue:
hypotonia (cvs+)
muscle weakness (cvs+)
delayed motor development (cvs+)
exercise intolerance (cvs+)

Abdomen Gastrointestinal:
abdominal pain
anorexia
nausea
gastrointestinal dysmotility (cvs+)

Growth Other:
growth retardation

Head And Neck Ears:
hearing loss (cvs+)

Cardiovascular Heart:
cardiomyopathy (cvs+)

Neurologic Behavioral Psychiatric Manifestations:
attention deficit-hyperactivity disorder (cvs+)
autism (cvs+)
pervasive developmental disorder (cvs+)


Clinical features from OMIM:

500007

Human phenotypes related to Cyclic Vomiting Syndrome:

32 (show all 24)
# Description HPO Frequency HPO Source Accession
1 microcephaly 32 HP:0000252
2 hearing impairment 32 HP:0000365
3 strabismus 32 HP:0000486
4 autism 32 HP:0000717
5 pallor 32 HP:0000980
6 intellectual disability 32 HP:0001249
7 seizures 32 HP:0001250
8 ataxia 32 HP:0001251
9 muscular hypotonia 32 HP:0001252
10 lethargy 32 HP:0001254
11 motor delay 32 HP:0001270
12 generalized hypotonia 32 HP:0001290
13 muscle weakness 32 HP:0001324
14 growth delay 32 HP:0001510
15 cardiomyopathy 32 HP:0001638
16 vomiting 32 HP:0002013
17 nausea 32 HP:0002018
18 abdominal pain 32 HP:0002027
19 anorexia 32 HP:0002039
20 migraine 32 HP:0002076
21 gastrointestinal dysmotility 32 HP:0002579
22 exercise intolerance 32 HP:0003546
23 attention deficit hyperactivity disorder 32 HP:0007018
24 cognitive impairment 32 HP:0100543

UMLS symptoms related to Cyclic Vomiting Syndrome:


abdominal pain, lethargy, nausea, nausea and vomiting, vomiting, persistent vomiting, vomiting alone, signs and symptoms, digestive

Drugs & Therapeutics for Cyclic Vomiting Syndrome

Drugs for Cyclic Vomiting Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Haloperidol Approved Phase 4 52-86-8 3559
3
Ondansetron Approved Phase 4 99614-02-5 4595
4
Topiramate Approved Phase 4 97240-79-4 5284627
5 Neurotransmitter Agents Phase 4,Phase 3
6 Psychotropic Drugs Phase 4,Phase 3
7 decanoic acid Phase 4
8 Haloperidol decanoate Phase 4
9 Central Nervous System Depressants Phase 4
10 Serotonin Agents Phase 4
11 Serotonin Antagonists Phase 4
12 Gastrointestinal Agents Phase 4
13 Dermatologic Agents Phase 4,Phase 2
14 Tranquilizing Agents Phase 4
15 Anti-Anxiety Agents Phase 4
16 Dopamine Agents Phase 4
17 Dopamine Antagonists Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 2
19 Antiemetics Phase 4
20 Antipruritics Phase 4,Phase 2
21 Antipsychotic Agents Phase 4
22 Autonomic Agents Phase 4
23 Neuroprotective Agents Phase 4
24 Anticonvulsants Phase 4
25 Anti-Obesity Agents Phase 4
26 Protective Agents Phase 4
27
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
28
Desipramine Approved, Investigational Phase 3 50-47-5 2995
29
Baclofen Approved Phase 3 1134-47-0 2284
30 Adrenergic Agents Phase 3
31 Neurotransmitter Uptake Inhibitors Phase 3
32 Antidepressive Agents Phase 3
33 Antidepressive Agents, Tricyclic Phase 3
34 Proton Pump Inhibitors Phase 3
35
Capsaicin Approved Phase 2 404-86-4 1548943
36
Pancrelipase Approved, Investigational 53608-75-6
37
Coenzyme Q10 Approved, Investigational, Nutraceutical 303-98-0 5281915
38 Ubiquinone
39 Micronutrients
40 Trace Elements
41 Vitamins
42 pancreatin

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) Recruiting NCT03056482 Phase 4 Ondansetron 8mg;Haloperidol 0.05mg/kg;Haloperidol 0.1mg/kg
2 Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children Terminated NCT00286988 Phase 4 Topiramate
3 A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Completed NCT01265550 Phase 3 baclofen;Desipramine
4 Topical Capsaicin for Cyclical Vomiting Recruiting NCT03223350 Phase 2 Capsaicin 0.075% Cream;Placebos
5 Analysis of Q10 Coenzyme Efficacy for Long-term Treatment of Cyclic Vomiting Syndrome in Children Completed NCT03295760 Q10 Coenzyme
6 Quality of Life And Psychological Symptoms In Children With Cyclic Vomiting Syndrome (CVS) Completed NCT00743665
7 Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea Completed NCT00728026
8 Quality of Life (QOL), Coping and Psychological Symptoms in Children and Adolescents With Cyclic Vomiting Syndrome Completed NCT00728039
9 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
10 Auricular Neurostimulation for Cyclic Vomiting Syndrome Recruiting NCT03434652 Not Applicable
11 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
12 Infants Colics : Towards a Migrainous Origin ? Recruiting NCT03155360
13 Applying Nutrient Drink Test in Understanding Pathophysiology of CVS Enrolling by invitation NCT03470181
14 The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS) Withdrawn NCT00728104

Search NIH Clinical Center for Cyclic Vomiting Syndrome

Genetic Tests for Cyclic Vomiting Syndrome

Anatomical Context for Cyclic Vomiting Syndrome

MalaCards organs/tissues related to Cyclic Vomiting Syndrome:

41
Brain, Testes, Cortex, Heart

Publications for Cyclic Vomiting Syndrome

Articles related to Cyclic Vomiting Syndrome:

(show top 50) (show all 190)
# Title Authors Year
1
Cyclic vomiting syndrome: a case series and review of the literature. ( 29484154 )
2018
2
Family Health-related Quality of Life in Pediatric Cyclic Vomiting Syndrome. ( 29697487 )
2018
3
Cyclic vomiting syndrome: epidemiology, diagnosis, and treatment. ( 29442203 )
2018
4
Cyclic vomiting syndrome: the nervous system has the guts. ( 29470758 )
2018
5
An overview of the clinical management of cyclic vomiting syndrome in childhood. ( 29484898 )
2018
6
Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis. ( 29969994 )
2018
7
Cyclic Vomiting Syndrome in Children. ( 29556858 )
2018
8
Cyclic vomiting syndrome: diagnostic approach and current management strategies. ( 29520160 )
2018
9
Cyclic Vomiting Syndrome ( 29763194 )
2018
10
Continuing Medical Education Questions: January 2018: Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. ( 29311736 )
2018
11
Yield and Costs of Evaluating Children with Cyclic Vomiting Syndrome. ( 29373437 )
2018
12
Cyclic Vomiting Syndrome. ( 29437134 )
2018
13
Depression, young age, chronic marijuana use, and interepisodic symptoms predict psychological distress in patients with cyclic vomiting syndrome. ( 29152814 )
2017
14
Cyclic vomiting syndrome after acute autonomic and sensory neuropathy. ( 28244649 )
2017
15
Cyclic vomiting syndrome is a prevalent and under-recognized condition in the gastroenterology outpatient clinic. ( 28745840 )
2017
16
Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults: recognition, diagnosis, acute and long-term treatment. ( 28400711 )
2017
17
Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. ( 28719594 )
2017
18
Cyclic Vomiting Syndrome: Randomized Controlled Trials Are also Needed in Adults. ( 29109491 )
2017
19
Cyclic Vomiting Syndrome in Adults and Children: A Hypothesis. ( 28488756 )
2017
20
Recurrent Gastrointestinal Disturbance: Abdominal Migraine and Cyclic Vomiting Syndrome. ( 28283964 )
2017
21
[Cyclic vomiting syndrome in children]. ( 28947248 )
2017
22
The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran. ( 29358999 )
2017
23
A Recurrent Theme: A Nationwide Analysis of Hospitalization for Cyclic Vomiting Syndrome. ( 28194596 )
2017
24
Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome. ( 28349993 )
2017
25
Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis. ( 28050780 )
2017
26
Problems in the Diagnosis of Cyclic Vomiting Syndrome in Children. ( 28461835 )
2016
27
Symptomatic management of a child with cyclic vomiting syndrome. ( 27530876 )
2016
28
Cyclic vomiting syndrome versus inborn errors of metabolism: A review with clinical recommendations. ( 26678622 )
2016
29
Prognosis of Cyclic Vomiting Syndrome. ( 27004140 )
2016
30
Novel Treatments for Cyclic Vomiting Syndrome: Beyond Ondansetron and Amitriptyline. ( 27757817 )
2016
31
Gastric Electrical Stimulation as Potential Treatment in Drug Refractory Cyclic Vomiting Syndrome. ( 27241799 )
2016
32
Cyclic vomiting syndrome, inborn errors of metabolism, migraine variants, episodic syndromes that may be associated with migraine, and other unusual pediatric headache syndromes. ( 26790854 )
2016
33
Anesthetic Considerations for the Patient With Cyclic Vomiting Syndrome. ( 26939389 )
2016
34
The Cyclic Vomiting Syndrome Threshold: A Framework for Understanding Pathogenesis and Predicting Successful Treatments. ( 27787513 )
2016
35
Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome. ( 27098832 )
2016
36
Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: a cross-comparison with migraine and healthy adults. ( 27910222 )
2016
37
Cyclic Vomiting Syndrome: An Update Illustrated by a Case Report. ( 27733950 )
2016
38
Cyclic Vomiting Syndrome in Infants and Children: A Clinical Follow-Up Study. ( 26861170 )
2016
39
Anxiety and physiological responses to the Trier Social Stress Test for Children in adolescents with cyclic vomiting syndrome. ( 27554769 )
2016
40
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
41
Case 2: Severe headache and paroxysmal seizures in a 14-year-old boy with cyclic vomiting syndrome. ( 25838778 )
2015
42
OnabotulinumtoxinA Injections for the Treatment of Cyclic Vomiting Syndrome. ( 25823714 )
2015
43
Cyclic vomiting syndrome. ( 25638903 )
2015
44
Challenges With Acute Care and Response to Treatment Among Adult Patients With Cyclic Vomiting Syndrome. ( 26626034 )
2015
45
Cyclic Vomiting Syndrome: A Functional Disorder. ( 26770896 )
2015
46
Pediatric Emergency Update: Cyclic Vomiting Syndrome. ( 25814094 )
2015
47
NextGen nuclear DNA sequencing in cyclic vomiting syndrome reveals a significant association with the stress-induced calcium channel (RYR2). ( 25925909 )
2015
48
Type 1 diabetes complicated with uncontrollable adult cyclic vomiting syndrome: a case report. ( 26401489 )
2015
49
Cyclic vomiting syndrome in multisystem mitochondrial disorder. ( 26757496 )
2015
50
Combination of erythromycin and propranolol for treatment of childhood cyclic vomiting syndrome: a novel regimen. ( 26468347 )
2015

Variations for Cyclic Vomiting Syndrome

ClinVar genetic disease variations for Cyclic Vomiting Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-TL1 m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh37 Chromosome MT, 3243: 3243
2 MT-TL1 m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh38 Chromosome MT, 3243: 3243

Expression for Cyclic Vomiting Syndrome

Search GEO for disease gene expression data for Cyclic Vomiting Syndrome.

Pathways for Cyclic Vomiting Syndrome

Pathways related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 HTR3A IL6 RYR2
2 11.21 IL6 OPRM1
3 9.74 CNR1 RYR2

GO Terms for Cyclic Vomiting Syndrome

Cellular components related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcolemma GO:0042383 8.96 OPRM1 RYR2
2 axon GO:0030424 8.8 CNR1 HTR3A OPRM1

Biological processes related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory postsynaptic potential GO:0060079 9.37 HTR3A OPRM1
2 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.32 CNR1 OPRM1
3 sensory perception of pain GO:0019233 9.26 CNR1 OPRM1
4 response to morphine GO:0043278 9.16 CNR1 OPRM1
5 response to ethanol GO:0045471 9.13 CNR1 HTR3A OPRM1
6 response to cocaine GO:0042220 8.8 CNR1 HTR3A OPRM1

Sources for Cyclic Vomiting Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....