CVS
MCID: CYC008
MIFTS: 52

Cyclic Vomiting Syndrome (CVS)

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cyclic Vomiting Syndrome

MalaCards integrated aliases for Cyclic Vomiting Syndrome:

Name: Cyclic Vomiting Syndrome 58 77 54 26
Cyclical Vomiting Syndrome 26 6 74
Cvs 58 54 26
Abdominal Migraine 26 74
Familial Cyclic Vomiting Syndrome 54
Cyclical Vomiting 26
Periodic Vomiting 26

Characteristics:

OMIM:

58
Inheritance:
multifactorial
mitochondrial

Miscellaneous:
mean age at onset 5 years
mean age at resolution of symptoms 10 years
cyclic vomiting syndrome plus (cvs+) is characterized by additional neuromuscular and/or visceral organ manifestations (as indicated above)


HPO:

33
cyclic vomiting syndrome:
Inheritance multifactorial inheritance mitochondrial inheritance


Classifications:



Summaries for Cyclic Vomiting Syndrome

NIH Rare Diseases : 54 Cyclic vomiting syndrome (CVS) is a condition characterized by recurrent, prolonged episodes of severe nausea and vomiting. Episodes of vomiting may last hours or days. Other signs and symptoms during episodes may include intense sweating, paleness, weakness and fatigue, abdominal pain, diarrhea, fever, dizziness, and headache. Most people with CVS are symptom-free in between episodes, but some people have milder symptoms. The condition can begin at any age, but it most often begins in childhood. A subset of people with CVS also have neurologic or neuromuscular disorders; the condition in these cases is referred to as "CVS plus." The underlying cause of CVS is unknown. Data suggest there is a strong genetic component for CVS in children, involving changes (mutations) in mitochondrial DNA. Researchers believe that the condition primarily affects the brain, causing abnormalities in how the brain and gut interact. Many people with CVS report "triggers" for episodes, such as excitement, stress, infections, eating certain foods, and menstruation. People with a family history of migraines may be more likely to develop CVS. Treatment strategies for controlling symptoms may include avoiding triggers, medications to prevent or relieve nausea, tricyclic antidepressants, anti-migraine medications, and supplements called coenzyme Q-10 and L-carnitine. While some people with CVS outgrow the condition within a few years, others continue to have episodes through adulthood. Children who outgrow CVS may go on to develop migraines. 

MalaCards based summary : Cyclic Vomiting Syndrome, also known as cyclical vomiting syndrome, is related to migraine with or without aura 1 and anxiety, and has symptoms including nausea and vomiting, vomiting and abdominal pain. An important gene associated with Cyclic Vomiting Syndrome is MT-TL1 (Mitochondrially Encoded TRNA-Leu (UUA/G) 1), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Interleukin-4 and 13 signaling. The drugs Ondansetron and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and heart, and related phenotypes are intellectual disability and seizures

Genetics Home Reference : 26 Cyclic vomiting syndrome is a disorder that causes recurrent episodes of nausea, vomiting, and tiredness (lethargy). This condition is diagnosed most often in young children, but it can affect people of any age.

Wikipedia : 77 Cyclic vomiting syndrome (US English) or cyclical vomiting syndrome (UK English) is a chronic functional... more...

Description from OMIM: 500007

Related Diseases for Cyclic Vomiting Syndrome

Diseases related to Cyclic Vomiting Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 30.2 CNR1 HTR3A
2 anxiety 29.8 CNR1 HTR3A
3 pain agnosia 29.7 CNR1 OPRM1
4 dihydropyrimidinase deficiency 11.2
5 neu-laxova syndrome 1 11.1
6 anophthalmos with limb anomalies 11.1
7 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 11.1
8 trisomy 2 mosaicism 11.1
9 haemophilus influenzae 10.5
10 bowenoid papulosis 10.3
11 rabies 10.2
12 headache 10.2
13 pulmonary alveolar microlithiasis 10.2
14 japanese encephalitis 10.2
15 encephalitis 10.2
16 nevus comedonicus 10.2
17 amnestic disorder 10.1 CNR1 HTR3A
18 withdrawal disorder 10.1 CNR1 OPRM1
19 arthritis 10.1
20 agnosia 10.1 CNR1 OPRM1
21 aplasia cutis congenita, nonsyndromic 10.1
22 multiple sclerosis 10.1
23 tetralogy of fallot 10.1
24 drug dependence 10.1 CNR1 OPRM1
25 uremic pruritus 10.0 CNR1 IL6
26 fibromyalgia 10.0 HTR3A IL6
27 rheumatoid arthritis 10.0
28 glucose intolerance 10.0
29 xp22.3 microdeletion syndrome 10.0
30 inherited metabolic disorder 10.0
31 neuropathy 10.0
32 specific developmental disorder 10.0 CNR1 OPRM1
33 constipation 10.0 HTR3A OPRM1
34 arteries, anomalies of 10.0
35 down syndrome 10.0
36 polycythemia vera 10.0
37 stroke, ischemic 10.0
38 acromegaly 10.0
39 adenoma 10.0
40 albinism 10.0
41 chromosomal triplication 10.0
42 bone cancer 10.0 CNR1 IL6
43 overnutrition 9.9 CNR1 IL6
44 alcohol dependence 9.9 CNR1 HTR3A OPRM1
45 colorectal cancer 9.9
46 diabetes mellitus, noninsulin-dependent 9.9
47 fish-eye disease 9.9
48 guillain-barre syndrome, familial 9.9
49 otitis media 9.9
50 pituitary adenoma, prolactin-secreting 9.9

Graphical network of the top 20 diseases related to Cyclic Vomiting Syndrome:



Diseases related to Cyclic Vomiting Syndrome

Symptoms & Phenotypes for Cyclic Vomiting Syndrome

Human phenotypes related to Cyclic Vomiting Syndrome:

33 (show all 24)
# Description HPO Frequency HPO Source Accession
1 intellectual disability 33 HP:0001249
2 seizures 33 HP:0001250
3 ataxia 33 HP:0001251
4 muscular hypotonia 33 HP:0001252
5 muscle weakness 33 HP:0001324
6 hearing impairment 33 HP:0000365
7 microcephaly 33 HP:0000252
8 cognitive impairment 33 HP:0100543
9 vomiting 33 HP:0002013
10 pallor 33 HP:0000980
11 abdominal pain 33 HP:0002027
12 strabismus 33 HP:0000486
13 autism 33 HP:0000717
14 attention deficit hyperactivity disorder 33 HP:0007018
15 growth delay 33 HP:0001510
16 cardiomyopathy 33 HP:0001638
17 anorexia 33 HP:0002039
18 migraine 33 HP:0002076
19 motor delay 33 HP:0001270
20 lethargy 33 HP:0001254
21 generalized hypotonia 33 HP:0001290
22 exercise intolerance 33 HP:0003546
23 nausea 33 HP:0002018
24 gastrointestinal dysmotility 33 HP:0002579

Symptoms via clinical synopsis from OMIM:

58
Skin Nails Hair Skin:
pallor

Neurologic Central Nervous System:
lethargy
vomiting, episodic
rapid onset
occurs most often during the night or early morning
peak frequency of vomiting every 10 to 15 minutes
more
Head And Neck Head:
microcephaly (in patients with 'cvs-plus,' cvs+)

Head And Neck Eyes:
strabismus (cvs+)

Muscle Soft Tissue:
hypotonia (cvs+)
muscle weakness (cvs+)
delayed motor development (cvs+)
exercise intolerance (cvs+)

Abdomen Gastrointestinal:
abdominal pain
anorexia
nausea
gastrointestinal dysmotility (cvs+)

Growth Other:
growth retardation

Head And Neck Ears:
hearing loss (cvs+)

Cardiovascular Heart:
cardiomyopathy (cvs+)

Neurologic Behavioral Psychiatric Manifestations:
attention deficit-hyperactivity disorder (cvs+)
autism (cvs+)
pervasive developmental disorder (cvs+)

Clinical features from OMIM:

500007

UMLS symptoms related to Cyclic Vomiting Syndrome:


nausea and vomiting, vomiting, abdominal pain, lethargy, nausea, signs and symptoms, digestive, vomiting alone, persistent vomiting

Drugs & Therapeutics for Cyclic Vomiting Syndrome

Drugs for Cyclic Vomiting Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 4 99614-02-5 4595
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Haloperidol Approved Phase 4 52-86-8 3559
4
Topiramate Approved Phase 4 97240-79-4 5284627
5 Neurotransmitter Agents Phase 4,Phase 3
6 Psychotropic Drugs Phase 4,Phase 3
7 Peripheral Nervous System Agents Phase 4,Phase 2
8 Autonomic Agents Phase 4
9 Anti-Anxiety Agents Phase 4
10 Dopamine Antagonists Phase 4
11 Central Nervous System Depressants Phase 4
12 Gastrointestinal Agents Phase 4
13 Antipsychotic Agents Phase 4
14 Serotonin Antagonists Phase 4
15 Antiemetics Phase 4
16 Antipruritics Phase 4,Phase 2
17 Haloperidol decanoate Phase 4
18 Dermatologic Agents Phase 4,Phase 2
19 Tranquilizing Agents Phase 4
20 Dopamine Agents Phase 4
21 Serotonin Agents Phase 4
22 Hypoglycemic Agents Phase 4
23 Anticonvulsants Phase 4
24
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
25
Desipramine Approved, Investigational Phase 3 50-47-5 2995
26
Baclofen Approved Phase 3 1134-47-0 2284
27
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
28 Proton Pump Inhibitors Phase 3
29 Antidepressive Agents Phase 3
30 Antidepressive Agents, Tricyclic Phase 3
31 Adrenergic Agents Phase 3
32 Neurotransmitter Uptake Inhibitors Phase 3
33
Capsaicin Approved Phase 2 404-86-4 1548943
34
Pancrelipase Approved, Investigational 53608-75-6
35
Coenzyme Q10 Approved, Investigational, Nutraceutical 303-98-0 5281915
36 Micronutrients
37 Nutrients
38 Vitamins
39 Ubiquinone
40 Trace Elements
41 pancreatin

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) Recruiting NCT03056482 Phase 4 Ondansetron 8mg;Haloperidol 0.05mg/kg;Haloperidol 0.1mg/kg
2 Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children Terminated NCT00286988 Phase 4 Topiramate
3 A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Completed NCT01265550 Phase 3 baclofen;Desipramine
4 Topical Capsaicin for Cyclical Vomiting Recruiting NCT03223350 Phase 2 Capsaicin 0.075% Cream;Placebos
5 Analysis of Q10 Coenzyme Efficacy for Long-term Treatment of Cyclic Vomiting Syndrome in Children Completed NCT03295760 Q10 Coenzyme
6 Quality of Life And Psychological Symptoms In Children With Cyclic Vomiting Syndrome (CVS) Completed NCT00743665
7 Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea Completed NCT00728026
8 Quality of Life (QOL), Coping and Psychological Symptoms in Children and Adolescents With Cyclic Vomiting Syndrome Completed NCT00728039
9 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
10 Auricular Neurostimulation for Cyclic Vomiting Syndrome Recruiting NCT03434652 Not Applicable
11 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
12 Infants Colics : Towards a Migrainous Origin ? Recruiting NCT03155360
13 Applying Nutrient Drink Test in Understanding Pathophysiology of CVS Enrolling by invitation NCT03470181
14 The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS) Withdrawn NCT00728104

Search NIH Clinical Center for Cyclic Vomiting Syndrome

Genetic Tests for Cyclic Vomiting Syndrome

Anatomical Context for Cyclic Vomiting Syndrome

MalaCards organs/tissues related to Cyclic Vomiting Syndrome:

42
Brain, Pituitary, Heart, Testes, Thyroid, Eye, Colon

Publications for Cyclic Vomiting Syndrome

Articles related to Cyclic Vomiting Syndrome:

(show top 50) (show all 488)
# Title Authors Year
1
Recent trends in cyclic vomiting syndrome-associated hospitalisations with liberalisation of cannabis use in the state of Colorado. ( 30426628 )
2019
2
Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome. ( 30613204 )
2019
3
Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a high risk of developing primary headache: A longitudinal study. ( 30982347 )
2019
4
CVS share fall prompts acquisitions rethink. ( 30705203 )
2019
5
Faculty Applicants' Attempt to Inflate CVs Using Predatory Journals. ( 30894776 )
2019
6
Depression, young age, chronic marijuana use, and interepisodic symptoms predict psychological distress in patients with cyclic vomiting syndrome. ( 29152814 )
2018
7
Continuing Medical Education Questions: January 2018: Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. ( 29311736 )
2018
8
Yield and Costs of Evaluating Children With Cyclic Vomiting Syndrome. ( 29373437 )
2018
9
Cyclic Vomiting Syndrome. ( 29437134 )
2018
10
Cyclic vomiting syndrome: epidemiology, diagnosis, and treatment. ( 29442203 )
2018
11
Cyclic vomiting syndrome: the nervous system has the guts. ( 29470758 )
2018
12
Cyclic vomiting syndrome: a case series and review of the literature. ( 29484154 )
2018
13
An overview of the clinical management of cyclic vomiting syndrome in childhood. ( 29484898 )
2018
14
Cyclic vomiting syndrome: diagnostic approach and current management strategies. ( 29520160 )
2018
15
Cyclic Vomiting Syndrome in Children. ( 29556858 )
2018
16
Family Health-related Quality of Life in Pediatric Cyclic Vomiting Syndrome. ( 29697487 )
2018
17
Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis. ( 29969994 )
2018
18
Managing cyclic vomiting syndrome in children: beyond the guidelines. ( 30076469 )
2018
19
Cyclic Vomiting Syndrome in Children and Adults: What Is New in 2018? ( 30159612 )
2018
20
Migraine, Cyclic Vomiting Syndrome, and Other Gastrointestinal Disorders. ( 30361855 )
2018
21
Emphysematous Gastritis in a Patient with Untreated Cyclic Vomiting Syndrome. ( 30775393 )
2018
22
Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. ( 28719594 )
2018
23
Cyclic vomiting syndrome is a prevalent and under-recognized condition in the gastroenterology outpatient clinic. ( 28745840 )
2018
24
Prenatal diagnosis of Pallister-Killian syndrome in pregnancy with normal CVS result and abnormal ultrasound findings in the second trimester. ( 30342660 )
2018
25
Feasibility and Safety of Chorionic Villus Sampling (CVS) for Prenatal Diagnosis of Thalassemia in Bangladesh. ( 30141449 )
2018
26
Changes in physiological and some nutritional, nutraceuticals, chemical-physical, microbiological and sensory quality of minimally processed cactus pears cvs 'Bianca', 'Gialla' and 'Rossa' stored under passive modified atmosphere. ( 28885688 )
2018
27
The CVS-Aetna Merger: Another Large Bet on the Changing U.S. Health Care Landscape. ( 29310130 )
2018
28
Individual shrink wrapping extends the storage life and maintains the quality of pomegranates (cvs. 'Mridula' and 'Bhagwa') at ambient and low temperature. ( 29358828 )
2018
29
CVS effects of ▼ canagliflozin. ( 29431611 )
2018
30
Does CVS-Aetna Spell the End of Business as Usual? ( 29443670 )
2018
31
The CVS Effect on American Health Insurance. ( 29595468 )
2018
32
Metabolomics and antioxidant activity of the leaves of Prunus dulcis Mill. (Italian cvs. Toritto and Avola). ( 29860179 )
2018
33
Influence of Temperature on Susceptibility of CVS. Tifguard and Georgia-06G Peanut to Meloidogyne arenaria. ( 30335910 )
2018
34
Genetic abnormalities seen on CVS in early pregnancy failure. ( 30373416 )
2018
35
Characterisation of Monovarietal Olive Oils Obtained from Croatian cvs. Drobnica and Buza during the Ripening Period. ( 30428616 )
2018
36
CVS and the $100,000 QALY. ( 30620315 )
2018
37
The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran. ( 29358999 )
2017
38
Anxiety and physiological responses to the Trier Social Stress Test for Children in adolescents with cyclic vomiting syndrome. ( 27554769 )
2017
39
Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults. ( 27910222 )
2017
40
Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis. ( 28050780 )
2017
41
A Recurrent Theme: A Nationwide Analysis of Hospitalization for Cyclic Vomiting Syndrome. ( 28194596 )
2017
42
Cyclic vomiting syndrome after acute autonomic and sensory neuropathy. ( 28244649 )
2017
43
Recurrent Gastrointestinal Disturbance: Abdominal Migraine and Cyclic Vomiting Syndrome. ( 28283964 )
2017
44
Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome. ( 28349993 )
2017
45
Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults: recognition, diagnosis, acute and long-term treatment. ( 28400711 )
2017
46
Cyclic Vomiting Syndrome in Adults and Children: A Hypothesis. ( 28488756 )
2017
47
Cyclic Vomiting Syndrome: Randomized Controlled Trials Are also Needed in Adults. ( 29109491 )
2017
48
Comparison of adverse perinatal outcomes after single-needle and double-needle CVS techniques. ( 27276527 )
2017
49
Temperature and CO2 dependency of the photosynthetic photon flux density responses of leaves of Vitis vinifera cvs. Chardonnay and Merlot grown in a hot climate. ( 27987474 )
2017
50
Predicting Unsuccessful Electrical Cardioversion for Acute Atrial Fibrillation (from the AF-CVS Score). ( 28017305 )
2017

Variations for Cyclic Vomiting Syndrome

ClinVar genetic disease variations for Cyclic Vomiting Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-TL1 NC_012920.1: m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh37 Chromosome MT, 3243: 3243
2 MT-TL1 NC_012920.1: m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh38 Chromosome MT, 3243: 3243

Expression for Cyclic Vomiting Syndrome

Search GEO for disease gene expression data for Cyclic Vomiting Syndrome.

Pathways for Cyclic Vomiting Syndrome

Pathways related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 HTR3A IL6 RYR2
2 11.21 IL6 OPRM1
3 9.74 CNR1 RYR2

GO Terms for Cyclic Vomiting Syndrome

Cellular components related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.33 CNR1 HTR3A OPRM1
2 sarcolemma GO:0042383 9.26 OPRM1 RYR2
3 integral component of postsynaptic membrane GO:0099055 8.96 HTR3A OPRM1
4 integral component of presynaptic membrane GO:0099056 8.8 CNR1 HTR3A OPRM1

Biological processes related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory postsynaptic potential GO:0060079 9.37 HTR3A OPRM1
2 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.32 CNR1 OPRM1
3 sensory perception of pain GO:0019233 9.26 CNR1 OPRM1
4 response to morphine GO:0043278 9.16 CNR1 OPRM1
5 response to ethanol GO:0045471 9.13 CNR1 HTR3A OPRM1
6 response to cocaine GO:0042220 8.8 CNR1 HTR3A OPRM1

Sources for Cyclic Vomiting Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....