Aliases & Classifications for Cycloplegia

MalaCards integrated aliases for Cycloplegia:

Name: Cycloplegia 12 15 17 71
Cycloplegic Paralysis of Accommodation 12
Paresis of Accommodation 12
Ciliary Muscle Paresis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10033
ICD9CM 34 367.51
SNOMED-CT 67 68158006
ICD10 32 H52.52
UMLS 71 C0235238

Summaries for Cycloplegia

MalaCards based summary : Cycloplegia, also known as cycloplegic paralysis of accommodation, is related to suppression amblyopia and strabismus, and has symptoms including mydriasis An important gene associated with Cycloplegia is IFITM2 (Interferon Induced Transmembrane Protein 2). The drugs Pseudoephedrine and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and heart.

Wikipedia : 74 Cycloplegia is paralysis of the ciliary muscle of the eye, resulting in a loss of accommodation. Because... more...

Related Diseases for Cycloplegia

Diseases related to Cycloplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 suppression amblyopia 31.1 DSE DPT
2 strabismus 30.7 SFTA3 DSE DPT CYLC1
3 accommodative spasm 30.6 IFITM2 CYLC1
4 amblyopia 30.3 SFTA3 IFITM2 DSE DPT CYLC1
5 esotropia 30.2 SFTA3 DSE DPT CYLC1
6 anisometropia 29.6 SFTA3 IFITM2 DSE DPT CYLC1 CTSC
7 astigmatism 29.4 NBL1 IFITM2 GREM2 DSE DPT CYLC1
8 refractive error 10.8
9 myopia 10.6
10 mechanical strabismus 10.5
11 aniseikonia 10.4 DSE DPT
12 farsightedness 10.3
13 choroid cancer 10.3 IFITM2 CYLC1
14 ocular motor apraxia 10.3
15 secondary corneal edema 10.3 SFTA3 CYLC1
16 irregular astigmatism 10.2 IFITM2 CYLC1
17 abducens nerve disease 10.2 SFTA3 CYLC1
18 central corneal ulcer 10.2 SFTA3 CER1
19 corneal ectasia 10.2 IFITM2 CYLC1
20 vitreous syneresis 10.2 SFTA3 CYLC1
21 monocular esotropia 10.2
22 presbyopia 10.2 IFITM2 CTSC
23 retinal lattice degeneration 10.1 SFTA3 DPT CYLC1
24 regular astigmatism 10.1 DPT CYLC1 CER1
25 spherocytosis, type 2 10.1 SFTA3 CYLC1
26 exotropia 10.0 DPT CYLC1
27 exudative vitreoretinopathy 1 10.0
28 glaucoma, primary open angle 10.0
29 retinal detachment 10.0
30 macular degeneration, age-related, 1 10.0
31 intraocular pressure quantitative trait locus 10.0
32 hydrops, lactic acidosis, and sideroblastic anemia 10.0
33 keratoconus 10.0
34 parotitis 10.0
35 open-angle glaucoma 10.0
36 macular retinal edema 10.0
37 cataract 10.0
38 diabetes mellitus 10.0
39 accommodative esotropia 10.0
40 headache 10.0
41 myopic macular degeneration 10.0
42 ametropic amblyopia 10.0 NBL1 DSE DPT CYLC1
43 spherocytosis, type 1 9.8 SFTA3 CYLC1
44 transient refractive change 9.7 IRX6 IRX3
45 eye accommodation disease 8.4 SFTA3 POTEC NBL1 IFITM2 GREM2 DSE

Graphical network of the top 20 diseases related to Cycloplegia:



Diseases related to Cycloplegia

Symptoms & Phenotypes for Cycloplegia

UMLS symptoms related to Cycloplegia:


mydriasis

Drugs & Therapeutics for Cycloplegia

Drugs for Cycloplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pseudoephedrine Approved Phase 4 90-82-4 7028
2
Ephedrine Approved Phase 4 299-42-3 9294
3
Cyclopentolate Approved Phase 4 512-15-2 2905
4
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
5
Phenylephrine Approved Phase 4 59-42-7 6041
6
Tropicamide Approved, Investigational Phase 4 1508-75-4 5593
7
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
8 Sympathomimetics Phase 4
9 Adrenergic Agonists Phase 4
10 Vasoconstrictor Agents Phase 4
11 Nasal Decongestants Phase 4
12 Protective Agents Phase 4
13 Adrenergic Agents Phase 4
14 Mydriatics Phase 4
15 Neurotransmitter Agents Phase 4
16 Autonomic Agents Phase 4
17 Respiratory System Agents Phase 4
18 Muscarinic Antagonists Phase 4
19 Cholinergic Agents Phase 4
20 Parasympatholytics Phase 4
21 Cholinergic Antagonists Phase 4
22 Anti-Arrhythmia Agents Phase 4
23 Anti-Asthmatic Agents Phase 4
24 Adjuvants, Anesthesia Phase 4
25 Ophthalmic Solutions Phase 4
26 Anesthetics Phase 4
27 Bronchodilator Agents Phase 4
28 Pharmaceutical Solutions Phase 4

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A New More Efficient Cycloplegia Scheme Unknown status NCT02177539 Phase 4 Cyclopentolate;Cyclopentolate+tropicamide+phenylephrine
2 The Effects of Low Dose Atropine on Choroidal Thickness Completed NCT03544827 Phase 4 Atropine;Atropine
3 Atropine for Children and Adolescent Myopia Progression Study (ACAMP) Enrolling by invitation NCT03949101 Phase 4 Atropine Sulfate 1 % Ophthalmic Ointment and Atropine Sulfate 0.01% Eye Drop;atropine 0.01% eye drop
4 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
5 A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
6 Cycloplegic Delivery Investigation Completed NCT00472524
7 Short Term Refractive and Ocular Parameter Changes After Topical Atropine Completed NCT03839888 0.125% Atropine
8 Study of Myopia Acquisition and Prevention in a Randomised Trial Completed NCT00477620
9 Comparative Study of Cycloplegic Refraction and Subjective Refraction With Fogging in School Age Children Completed NCT00347347
10 CHAMPS Eye Study - Myopia and Retinal Vascular Geometry in Relation to Physical Activity. Completed NCT02346006
11 Randomized Clinical Trial on Atropine 0.01% for the Control of Myopia in Omani Children Recruiting NCT03508817 Early Phase 1 Atropine Sulfate 0.01% Eye Drops
12 Shanghai Child and Adolescent Large-scale Eye Study -High Myopia Registration Enrolling by invitation NCT03666052
13 Randomized, Controlled Trial of an Educational Intervention to Promote Spectacle Use Among Secondary School Children in Islamabad, Pakistan Not yet recruiting NCT03670303
14 Prevalence of New Psychoactive Substances Use Among Outpatient of Addiction Management Clinic in Assiut University Hospital Not yet recruiting NCT03695419
15 Évaluation de l'Utilisation d'un Photoscreener Comme méthode de dépistage Des problèmes Ophtalmologiques pédiatriques en Haïti Withdrawn NCT02655432
16 Myopia Progression in Children Wearing Near Center and Distance Center Multifocals - a Randomized Controlled Clinical Trial Withdrawn NCT03519490

Search NIH Clinical Center for Cycloplegia

Genetic Tests for Cycloplegia

Anatomical Context for Cycloplegia

MalaCards organs/tissues related to Cycloplegia:

40
Eye, Testes, Heart

Publications for Cycloplegia

Articles related to Cycloplegia:

(show top 50) (show all 808)
# Title Authors PMID Year
1
Bifocals reduce strabismus in children with Down syndrome: Evidence from a randomized controlled trial. 61
31313886 2020
2
National consensus statement regarding pediatric eye examination, refraction, and amblyopia management. 61
31957721 2020
3
Measuring changes in Schlemm's canal and trabecular meshwork in different accommodation states in myopia children: an observational study. 61
31399701 2020
4
Lower sensitivity to peripheral hypermetropic defocus due to higher order ocular aberrations. 61
32031730 2020
5
The Impact of Parental Rural-to-urban Migration on Children's Refractive Error in Rural China: A Propensity Score Matching Analysis. 61
31610685 2020
6
Refraction under general anesthesia in children, using cycloplegic refraction only as a reference. 61
31985321 2020
7
Association between serum 25-hydroxyvitamin D levels and myopia in general Korean adults. 61
31856458 2020
8
Accommodation response and spherical aberration during orthokeratology. 61
31720836 2020
9
A computational analysis of retinal image quality in eyes with keratoconus. 61
31992755 2020
10
Permavision intracorneal inlay after sixteen years. Regression of initial refractive hyperopia. 61
31812505 2019
11
Effect of Pupil Dilation with Tropicamide on Retinal Vascular Caliber. 61
31267797 2019
12
Effect of topical pilocarpine on refractive surgery outcomes. 61
31758508 2019
13
COMPLICATIONS OF SERIAL ANTERIOR CHAMBER PARACENTESIS FOR INCREASED INTRAOCULAR PRESSURE AFTER INTRAVITREAL INJECTIONS. 61
31688671 2019
14
Differences in ocular biometry between urban and rural children matched by refractive error: the Shandong Children Eye Study. 61
31696541 2019
15
Agreement and Repeatability of Noncycloplegic and Cycloplegic Wavefront-based Autorefraction in Children. 61
31703049 2019
16
Two-dimensional Peripheral Refraction and Retinal Image Quality in Emmetropic Children. 61
31700132 2019
17
Axial length elongation in primary school-age children: a 3-year cohort study in Shanghai. 61
31676647 2019
18
Central corneal thickness and corneal diameter in preterm and term newborns and preterm neonates at term. 61
31546483 2019
19
Low-dose (0.01%) atropine eye-drops to reduce progression of myopia in children: a multicentre placebo-controlled randomised trial in the UK (CHAMP-UK)-study protocol. 61
31653669 2019
20
Validation of an Affordable Handheld Wavefront Autorefractor. 61
31592955 2019
21
The Effect of Cycloplegia on the Ocular Biometric and Anterior Segment Parameters: A Cross-Sectional Study. 61
31054123 2019
22
The effect of cycloplegia on biometric measurements using swept-source optical coherence tomography-based biometry. 61
30834574 2019
23
Prolonged ocular exposure leads to retinal lesions in mice. 61
31128100 2019
24
[Emphasizing the standardized use of cycloplegics in the epidemiological studies of myopia]. 61
31422633 2019
25
[An investigation on professional performance of optometric refraction in spectacles stores in Anyang city of Henan Province]. 61
31422635 2019
26
Meeting the need for corrective spectacles in visually impaired Chinese school children: the potential of ready-made spectacles. 61
30279277 2019
27
Using Decision Curve Analysis to Evaluate Common Strategies for Myopia Screening in School-Aged Children. 61
31094286 2019
28
Risk factors for high myopia: a 22-year follow-up study from childhood to adulthood. 61
30460746 2019
29
Factors Affecting Pupil Reactivity After Cycloplegia in Asian Children. 61
31385819 2019
30
Elucidation of the more myopic eye in anisometropia: the interplay of laterality, ocular dominance, and anisometropic magnitude. 61
31270453 2019
31
Comparison of retinoscopy results with and without 1% cyclopentolate in school-aged children. 61
31236978 2019
32
Unilateral accommodation spasm: Case report and literature review. 61
30837173 2019
33
Disordered sleep and myopia among adolescents: a propensity score matching analysis. 61
30601071 2019
34
Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial. 61
30367541 2019
35
Distribution of scleral thickness and associated factors in 810 Chinese children and adolescents: a swept-source optical coherence tomography study. 61
30178606 2019
36
Cycloplegia and spectacle prescribing in children: attitudes of UK optometrists. 61
30957261 2019
37
The value of cycloplegia in optometric refraction of adults in a population study. 61
30318746 2019
38
Retinal oxygen saturation in 1461 healthy children aged 7-19 and its associated factors. 61
30714353 2019
39
Refractive Status in Children with Laser-Treated Retinopathy of Prematurity: Our Experience in Bulgaria. 61
31110577 2019
40
Malignant Glaucoma After Laser Peripheral Iridotomy. 61
30822298 2019
41
Effect of cycloplegia on the measurement of refractive error in Chinese children. 61
30136309 2019
42
Evaluation of vision screening in five- to eight-year-old children living in Region Västra Götaland, Sweden - a prospective multicentre study. 61
30280519 2019
43
Tropicamide has limited clinical effect on cycloplegia and mydriasis when combined with cyclopentolate and phenylephrine. 61
30641136 2019
44
Time to drop the phenylephrine from the paediatric cycloplegia protocol: informing practice through audit. 61
30353136 2019
45
Comparison of Autorefraction and Photorefraction with and without Cycloplegia Using 1% Tropicamide in Preschool Children. 61
31191991 2019
46
Corrigendum to "Clinical Performance of the Spot Vision Photo Screener before and after Induction of Cycloplegia in Children". 61
31565428 2019
47
Distribution and Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness and Its Association with Sleep Quality in Chinese Teenagers. 61
31583128 2019
48
Prevalence and Risk Factors of Myopia in Spain. 61
31531234 2019
49
Role of Gender in the Prevalence of Myopia among Polish Schoolchildren. 61
31341661 2019
50
Macular choroidal thickness in Chinese preschool children: decrease with axial length but no evident change with age. 61
31544044 2019

Variations for Cycloplegia

Expression for Cycloplegia

Search GEO for disease gene expression data for Cycloplegia.

Pathways for Cycloplegia

GO Terms for Cycloplegia

Biological processes related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of BMP signaling pathway GO:0030514 9.43 NBL1 GREM2 CER1
2 sequestering of BMP in extracellular matrix GO:0035582 9.16 NBL1 CER1
3 sequestering of BMP from receptor via BMP binding GO:0038098 8.96 NBL1 GREM2
4 determination of dorsal identity GO:0048263 8.8 NBL1 GREM2 CER1

Molecular functions related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 morphogen activity GO:0016015 8.96 NBL1 CER1
2 BMP binding GO:0036122 8.8 NBL1 GREM2 CER1

Sources for Cycloplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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