MCID: CYC001
MIFTS: 35

Cycloplegia

Categories: Eye diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Cycloplegia

MalaCards integrated aliases for Cycloplegia:

Name: Cycloplegia 12 15 17 70
Cycloplegic Paralysis of Accommodation 12
Paresis of Accommodation 12
Ciliary Muscle Paresis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10033
ICD9CM 34 367.51
SNOMED-CT 67 68158006
ICD10 32 H52.52
UMLS 70 C0235238

Summaries for Cycloplegia

Disease Ontology : 12 An eye accommodation disease that is characterized by paralysis of the ciliary muscle of the eye, resulting in a loss of accommodation.

MalaCards based summary : Cycloplegia, also known as cycloplegic paralysis of accommodation, is related to anisometropia and refractive error, and has symptoms including mydriasis An important gene associated with Cycloplegia is IRX6 (Iroquois Homeobox 6), and among its related pathways/superpathways is Phototransduction. The drugs Phenylephrine and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is vision/eye.

Wikipedia : 73 Cycloplegia is paralysis of the ciliary muscle of the eye, resulting in a loss of accommodation. Because... more...

Related Diseases for Cycloplegia

Diseases related to Cycloplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 anisometropia 29.8 SFTA3 SCO2
2 refractive error 10.6
3 myopia 10.5
4 strabismus 10.4
5 mechanical strabismus 10.4
6 astigmatism 10.3
7 lateral displacement of eye 10.3 IRX6 IRX3
8 aniseikonia 10.2 IRX6 IRX3
9 suppression amblyopia 10.2
10 amblyopia 10.2
11 transient refractive change 10.2 IRX6 IRX3
12 oligocone trichromacy 10.2 PDE6C GNAT2
13 farsightedness 10.1
14 night blindness, congenital stationary, type 2a 10.1 PDE6H GNAT2
15 colorblindness, partial, protan series 10.1 PDE6C GNAT2
16 ocular motor apraxia 10.1
17 monocular esotropia 10.1
18 esotropia 10.1
19 achromatopsia 7 10.0 PDE6H PDE6C GNAT2
20 red-green color blindness 10.0 PDE6H PDE6C GNAT2
21 achromatopsia 2 10.0 PDE6H PDE6C GNAT2
22 achromatopsia 3 10.0 PDE6H PDE6C GNAT2
23 jalili syndrome 10.0 PDE6C GNAT2
24 achromatopsia 4 10.0 PDE6H PDE6C GNAT2
25 blue cone monochromacy 10.0 PDE6H PDE6C GNAT2
26 accommodative esotropia 10.0
27 cone-rod dystrophy 6 10.0 PDE6H PDE6C GNAT2
28 eye accommodation disease 10.0 SLC5A7 KERA IRX6 IRX3
29 degenerative myopia 9.9 SCO2 PRSS56
30 exudative vitreoretinopathy 1 9.8
31 glaucoma, primary open angle 9.8
32 retinal detachment 9.8
33 macular degeneration, age-related, 1 9.8
34 keratoconus 9.8
35 parotitis 9.8
36 open-angle glaucoma 9.8
37 accommodative spasm 9.8
38 macular retinal edema 9.8
39 cataract 9.8
40 headache 9.8
41 myopic macular degeneration 9.8
42 choroidal dystrophy, central areolar, 1 9.8 PDE6H PDE6C
43 juvenile glaucoma 9.8 SCO2 KERA
44 primary angle-closure glaucoma 9.8 PRSS56 KERA
45 tritanopia 9.8 PDE6H PDE6C OPN4 GNAT2
46 color blindness 9.8 PDE6H PDE6C OPN4 GNAT2
47 eye degenerative disease 9.7 SFTA3 OPN4 GNAT2
48 cone dystrophy 9.5 SFTA3 PDE6H PDE6C GNAT2
49 congenital stationary night blindness 9.5 SFTA3 PDE6C OPN4 GNAT2
50 achromatopsia 9.4 SFTA3 PDE6H PDE6C OPN4 GNAT2

Graphical network of the top 20 diseases related to Cycloplegia:



Diseases related to Cycloplegia

Symptoms & Phenotypes for Cycloplegia

UMLS symptoms related to Cycloplegia:


mydriasis

MGI Mouse Phenotypes related to Cycloplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.28 GNAT2 IRX3 IRX6 KERA OPN4 PDE6C

Drugs & Therapeutics for Cycloplegia

Drugs for Cycloplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenylephrine Approved Phase 4 59-42-7 6041
2
Ephedrine Approved Phase 4 299-42-3 9294
3
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
4
Tropicamide Approved, Investigational Phase 4 1508-75-4 5593
5
Pseudoephedrine Approved Phase 4 90-82-4 7028
6
Cyclopentolate Approved Phase 4 512-15-2 2905
7 Respiratory System Agents Phase 4
8 Parasympatholytics Phase 4
9 Cholinergic Agents Phase 4
10 Cholinergic Antagonists Phase 4
11 Muscarinic Antagonists Phase 4
12 Adrenergic alpha-Agonists Phase 4
13 Cardiotonic Agents Phase 4
14 Nasal Decongestants Phase 4
15 Vasoconstrictor Agents Phase 4
16 Protective Agents Phase 4
17 Adrenergic Agonists Phase 4
18
Atropine Approved, Vet_approved 5908-99-6, 51-55-8 174174
19
Methamphetamine Approved, Illicit 537-46-2 10836
20
Dopamine Approved 51-61-6, 62-31-7 681
21 Anti-Arrhythmia Agents
22 Anti-Asthmatic Agents
23 Anesthetics
24 Bronchodilator Agents
25 Ophthalmic Solutions
26 Mydriatics
27 Neurotransmitter Agents
28 Adrenergic Agents
29 Sympathomimetics
30 Central Nervous System Stimulants
31 Dopamine Agents
32 Dopamine Uptake Inhibitors
33 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A New More Efficient Cycloplegia Scheme Unknown status NCT02177539 Phase 4 Cyclopentolate;Cyclopentolate+tropicamide+phenylephrine
2 Short Term Refractive and Ocular Parameter Changes After Topical Atropine Completed NCT03839888 0.125% Atropine
3 Age-Related Changes and Cycloplegia-Induced Differences of the Human Crystalline Lens, Schlemm' s Canal and Trabecular Meshwork:an in Vivo Swept-Source Optical Coherence Tomography Study Completed NCT04576884
4 Atropine 0.01% Eyedrops for Evolutive Myopia Treatment in Children. MYOPSTOP Recruiting NCT04252989
5 A Prospective School-based Study of Myopia in Children in Southern China Recruiting NCT04219228
6 The Refractive Accuracy of Photoscreeners "2WIN" and "PlusoptiX" and the "Retinomax" Auto Refractor Active, not recruiting NCT04249505
7 The Early Glasses Study: Can Early Glasses Prevent the Development of Amblyopia in Children With High Refractive Errors at Age One Not yet recruiting NCT04740593

Search NIH Clinical Center for Cycloplegia

Genetic Tests for Cycloplegia

Anatomical Context for Cycloplegia

MalaCards organs/tissues related to Cycloplegia:

40
Eye

Publications for Cycloplegia

Articles related to Cycloplegia:

(show top 50) (show all 857)
# Title Authors PMID Year
1
Short-term effect of atropine on higher-order aberrations in myopic children. 61
33496515 2021
2
Comparisons of atropine versus cyclopentolate cycloplegia in myopic children. 61
32844483 2021
3
Ocular Syphilis Causing Panophthalmitis. 61
32732543 2021
4
Subtle changes of the crystalline lens after cycloplegia: a retrospective study. 61
33676428 2021
5
Comparison of myopic progression in Finnish and Singaporean children. 61
32706181 2021
6
Phentolamine Eye Drops Reverse Pharmacologically Induced Mydriasis in a Randomized Phase 2b Trial. 61
33633016 2021
7
Effect of cyclopentolate versus tropicamide on anterior segment angle parameters in three refractive groups. 61
32519368 2021
8
Repeated measurements of ERGs and VEPs using chloral hydrate sedation and propofol anesthesia in young children. 61
33778913 2021
9
Baseline vision results from the Baltimore Reading and Eye Disease Study. 61
33745870 2021
10
The effects of pharmacological accommodation and cycloplegia on axial length and choroidal thickness. 61
33567004 2021
11
Difference of refractive status before and after cycloplegic refraction: the Lhasa Childhood Eye Study. 61
33656708 2021
12
The effect of cycloplegia on the ocular biometry and intraocular lens power based on age. 61
32796931 2021
13
Refraction and its development in young adults born prematurely and screened for retinopathy of prematurity. 61
33528099 2021
14
Axial Length Elongation in Japanese Youth With Myopia. 61
32740040 2021
15
Oscillopsia associated with pseudoaccommodation in pseudophakia. 61
32818350 2020
16
Coluber Constrictor Bite to the Eye: A Novel Case Report of a Wild Snake Bite to the Eye in North America and Review of Literature. 61
33489539 2020
17
Occlusion of AquaPORT Flow in a Case of Toxic Anterior Segment Syndrome Following Implantable Collamer Lens Surgery Causing Severe Pupillary Block. 61
33296000 2020
18
Combined passive and active treatment in strabismic amblyopia with accommodative component. 61
32996215 2020
19
Higher order aberrations and axial elongation in combined 0.01% atropine with orthokeratology for myopia control. 61
32888318 2020
20
Permavision intracorneal inlay after sixteen years. Regression of initial refractive hyperopia. 61
31812505 2020
21
Corneal and Ocular Residual Astigmatism in School-Age Children. 61
33553837 2020
22
[Significant Increase in Astigmatism after Cycloplegia in Two Children]. 61
32975092 2020
23
Broad Spectrum Treatment for Ocular Insult Induced by Organophosphate Chemical Warfare Agents. 61
32579218 2020
24
Efficacy of a Cycloplegic Agent Administered as a Spray in the Pediatric Population. 61
32956479 2020
25
Case Report: Transient Myopic Shift and Other Sequelae in Response to Adverse Reaction to Sulfamethoxazole-trimethoprim. 61
32833399 2020
26
Comparison of open-field autorefraction, closed-field autorefraction, and retinoscopy for refractive measurements of children and adolescents in Taiwan. 61
32354691 2020
27
Optical Aberrations of Guinea Pig Eyes. 61
32821915 2020
28
Prevalence and risk factors of pseudomyopia in a Chinese children population: the Anyang Childhood Eye Study. 61
32859718 2020
29
Effect of Tropicamide on crystalline Lens rise in low-to-moderate myopic eyes. 61
32778077 2020
30
Low-dose (0.01%) atropine eye-drops to reduce progression of myopia in children: a multicentre placebo-controlled randomised trial in the UK (CHAMP-UK)-study protocol. 61
31653669 2020
31
Spasm of Near Reflex: Objective Assessment of the Near-Triad. 61
32663291 2020
32
Evaluation of the Necessity for Cycloplegia During Refraction of Chinese Children Between 4 and 10 Years Old. 61
32687211 2020
33
The Effect of Cyclopentolate on Ocular Biometric Components. 61
32511166 2020
34
Refraction under general anesthesia in children, using cycloplegic refraction only as a reference. 61
31985321 2020
35
Vault changes after cyclopentolate instillation in eyes with posterior chamber phakic intraocular lens. 61
32541775 2020
36
Defocus Incorporated Multiple Segments Spectacle Lenses Changed the Relative Peripheral Refraction: A 2-Year Randomized Clinical Trial. 61
32460315 2020
37
Lower sensitivity to peripheral hypermetropic defocus due to higher order ocular aberrations. 61
32031730 2020
38
Short-term refractive and ocular parameter changes after topical atropine. 61
32874839 2020
39
Refractive status and optical components of premature babies with or without retinopathy of prematurity at 7 years old. 61
32477910 2020
40
[The performance of visual photoscreening for Chinese preschool children aged 4 to 5 years]. 61
32187947 2020
41
The Effect of Topical Cyclopentolate on Anterior Segment Parameters in Patients with Keratoconus 61
32167060 2020
42
Effect of topical pilocarpine on refractive surgery outcomes. 61
31758508 2020
43
National consensus statement regarding pediatric eye examination, refraction, and amblyopia management. 61
31957721 2020
44
Bifocals reduce strabismus in children with Down syndrome: Evidence from a randomized controlled trial. 61
31313886 2020
45
Higher-Order Aberrations and Axial Elongation in Myopic Children Treated With Orthokeratology. 61
32068792 2020
46
Associations Between Screen Exposure in Early Life and Myopia amongst Chinese Preschoolers. 61
32046062 2020
47
Measuring changes in Schlemm's canal and trabecular meshwork in different accommodation states in myopia children: an observational study. 61
31399701 2020
48
The Impact of Parental Rural-to-urban Migration on Children's Refractive Error in Rural China: A Propensity Score Matching Analysis. 61
31610685 2020
49
Assesment of the QuickSee wavefront autorefractor for characterizing refractive errors in school-age children. 61
33112912 2020
50
Cycloplegia in Children: An Optometrist's Perspective. 61
32904515 2020

Variations for Cycloplegia

Expression for Cycloplegia

Search GEO for disease gene expression data for Cycloplegia.

Pathways for Cycloplegia

Pathways related to Cycloplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11 PDE6H PDE6C GNAT2

GO Terms for Cycloplegia

Cellular components related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment membrane GO:0042622 8.62 PDE6H GNAT2

Biological processes related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.35 PDE6H PDE6C OPN4 KERA GNAT2
2 cell development GO:0048468 9.32 IRX6 IRX3
3 phototransduction GO:0007602 9.26 OPN4 GNAT2
4 retinal cone cell development GO:0046549 9.16 PDE6C GNAT2
5 visual perception GO:0007601 9.02 PDE6H PDE6C OPN4 KERA GNAT2

Molecular functions related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.26 PDE6H PDE6C
2 cGMP binding GO:0030553 9.16 PDE6H PDE6C
3 G protein-coupled photoreceptor activity GO:0008020 8.96 OPN4 GNAT2
4 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8.62 PDE6H PDE6C

Sources for Cycloplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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