Aliases & Classifications for Cycloplegia

MalaCards integrated aliases for Cycloplegia:

Name: Cycloplegia 12 15 17 71
Cycloplegic Paralysis of Accommodation 12
Paresis of Accommodation 12
Ciliary Muscle Paresis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10033
ICD9CM 34 367.51
SNOMED-CT 67 68158006
ICD10 32 H52.52
UMLS 71 C0235238

Summaries for Cycloplegia

MalaCards based summary : Cycloplegia, also known as cycloplegic paralysis of accommodation, is related to suppression amblyopia and strabismus, and has symptoms including mydriasis An important gene associated with Cycloplegia is IFITM2 (Interferon Induced Transmembrane Protein 2), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and Signaling by BMP. The drugs Phenylephrine and Cyclopentolate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and heart, and related phenotype is integument.

Wikipedia : 74 Cycloplegia is paralysis of the ciliary muscle of the eye, resulting in a loss of accommodation. Because... more...

Related Diseases for Cycloplegia

Diseases related to Cycloplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 suppression amblyopia 31.0 NBL1 DSE
2 strabismus 30.7 SFTA3 DSE DPT CYLC1
3 esotropia 30.6 DSE DPT CYLC1
4 amblyopia 30.4 SFTA3 IFITM2 DSE DPT CYLC1
5 accommodative spasm 30.3 IFITM2 CYLC1 CER1
6 astigmatism 29.2 NBL1 IFITM2 GREM2 GREM1 DSE DPT
7 anisometropia 28.4 SARS1 NBL1 IFITM2 GREM2 GREM1 DSE
8 refractive error 10.8
9 joint laxity, short stature, and myopia 10.6
10 myopia 10.6
11 mechanical strabismus 10.5
12 farsightedness 10.3
13 aniseikonia 10.3 DSE DPT
14 ocular motor apraxia 10.3
15 secondary corneal edema 10.2 SFTA3 CYLC1
16 central corneal ulcer 10.2 SFTA3 CER1
17 vitreous detachment 10.2 DPT CYLC1
18 monocular esotropia 10.2
19 vitreous syneresis 10.2 SFTA3 CYLC1
20 corneal ectasia 10.2 IFITM2 CYLC1
21 ametropic amblyopia 10.2 NBL1 DSE CYLC1
22 regular astigmatism 10.2 DPT CYLC1 CER1
23 irregular astigmatism 10.1 IFITM2 CYLC1 CER1
24 retinal lattice degeneration 10.1 SFTA3 DPT CYLC1
25 spherocytosis, type 2 10.1 SFTA3 CYLC1
26 exotropia 10.1 DPT CYLC1
27 lateral displacement of eye 10.0 IRX6 IRX3
28 exudative vitreoretinopathy 1 10.0
29 glaucoma, primary open angle 10.0
30 retinal detachment 10.0
31 macular degeneration, age-related, 1 10.0
32 intraocular pressure quantitative trait locus 10.0
33 keratoconus 10.0
34 parotitis 10.0
35 open-angle glaucoma 10.0
36 macular retinal edema 10.0
37 cataract 10.0
38 diabetes mellitus 10.0
39 accommodative esotropia 10.0
40 headache 10.0
41 myopic macular degeneration 10.0
42 transient refractive change 9.9 IRX6 IRX3
43 spherocytosis, type 1 9.8 SFTA3 CYLC1
44 norrie disease 9.8 GREM2 GREM1 CER1
45 presbyopia 9.7 NBL1 IFITM2 GREM2 DPT CTSC
46 eye accommodation disease 7.7 SFTA3 POTEC PIWIL2 NBL1 IRX6 IFITM2

Graphical network of the top 20 diseases related to Cycloplegia:



Diseases related to Cycloplegia

Symptoms & Phenotypes for Cycloplegia

UMLS symptoms related to Cycloplegia:


mydriasis

MGI Mouse Phenotypes related to Cycloplegia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 CTSC DPT DSE IRX6 KCND2 NBL1

Drugs & Therapeutics for Cycloplegia

Drugs for Cycloplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenylephrine Approved Phase 4 59-42-7 6041
2
Cyclopentolate Approved Phase 4 512-15-2 2905
3
Pseudoephedrine Approved Phase 4 90-82-4 7028
4
Ephedrine Approved Phase 4 299-42-3 9294
5
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
6
Tropicamide Approved, Investigational Phase 4 1508-75-4 5593
7
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
8 Adrenergic alpha-Agonists Phase 4
9 Cardiotonic Agents Phase 4
10 Nasal Decongestants Phase 4
11 Adrenergic Agents Phase 4
12 Vasoconstrictor Agents Phase 4
13 Adrenergic Agonists Phase 4
14 Protective Agents Phase 4
15 Sympathomimetics Phase 4
16 Mydriatics Phase 4
17 Respiratory System Agents Phase 4
18 Cholinergic Agents Phase 4
19 Parasympatholytics Phase 4
20 Muscarinic Antagonists Phase 4
21 Cholinergic Antagonists Phase 4
22 Neurotransmitter Agents Phase 4
23 Anti-Arrhythmia Agents Phase 4
24 Anti-Asthmatic Agents Phase 4
25 Ophthalmic Solutions Phase 4
26 Bronchodilator Agents Phase 4
27 Anesthetics Phase 4
28 Pharmaceutical Solutions Phase 4

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 A New More Efficient Cycloplegia Scheme Unknown status NCT02177539 Phase 4 Cyclopentolate;Cyclopentolate+tropicamide+phenylephrine
2 The Effects of Low Dose Atropine on Choroidal Thickness Completed NCT03544827 Phase 4 Atropine;Atropine
3 Atropine for Children and Adolescent Myopia Progression Study (ACAMP) Enrolling by invitation NCT03949101 Phase 4 Atropine Sulfate 1 % Ophthalmic Ointment and Atropine Sulfate 0.01% Eye Drop;atropine 0.01% eye drop
4 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
5 A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
6 Cycloplegic Delivery Investigation Completed NCT00472524
7 Morphology of Schlemm's Canal and Crystalline Lens in Different Age: a Swept-source Optical Coherence Tomography Study Completed NCT04360161
8 Short Term Refractive and Ocular Parameter Changes After Topical Atropine Completed NCT03839888 0.125% Atropine
9 Detection of Hyperopia by Photoscreener GoCheckKids With Glow Fixation Device Completed NCT04297969
10 Study of Myopia Acquisition and Prevention in a Randomised Trial Completed NCT00477620
11 Comparative Study of Cycloplegic Refraction and Subjective Refraction With Fogging in School Age Children Completed NCT00347347
12 CHAMPS Eye Study - Myopia and Retinal Vascular Geometry in Relation to Physical Activity. Completed NCT02346006
13 The Refractive Accuracy of Photoscreeners "2WIN" and "PlusoptiX" and the "Retinomax" Auto Refractor Recruiting NCT04249505
14 Atropine 0.01% Eyedrops for Evolutive Myopia Treatment in Children. MYOPSTOP Recruiting NCT04252989
15 A Prospective School-based Study of Myopia in Children in Southern China Recruiting NCT04219228
16 Randomized Clinical Trial on Atropine 0.01% for the Control of Myopia in Omani Children Recruiting NCT03508817 Early Phase 1 Atropine Sulfate 0.01% Eye Drops
17 Shanghai Child and Adolescent Large-scale Eye Study -High Myopia Registration Enrolling by invitation NCT03666052
18 A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles Plus Patching for Amblyopia in Children 3 to <13 Years Old Not yet recruiting NCT04378790
19 Randomized, Controlled Trial of an Educational Intervention to Promote Spectacle Use Among Secondary School Children in Islamabad, Pakistan Not yet recruiting NCT03670303
20 Prevalence of New Psychoactive Substances Use Among Outpatient of Addiction Management Clinic in Assiut University Hospital Not yet recruiting NCT03695419
21 Évaluation de l'Utilisation d'un Photoscreener Comme méthode de dépistage Des problèmes Ophtalmologiques pédiatriques en Haïti Withdrawn NCT02655432
22 Myopia Progression in Children Wearing Near Center and Distance Center Multifocals - a Randomized Controlled Clinical Trial Withdrawn NCT03519490

Search NIH Clinical Center for Cycloplegia

Genetic Tests for Cycloplegia

Anatomical Context for Cycloplegia

MalaCards organs/tissues related to Cycloplegia:

40
Eye, Testes, Heart

Publications for Cycloplegia

Articles related to Cycloplegia:

(show top 50) (show all 823)
# Title Authors PMID Year
1
Low-dose (0.01%) atropine eye-drops to reduce progression of myopia in children: a multicentre placebo-controlled randomised trial in the UK (CHAMP-UK)-study protocol. 61
31653669 2020
2
The Effect of Cyclopentolate on Ocular Biometric Components. 61
32511166 2020
3
Broad spectrum treatment for ocular Insult induced by organophosphate chemical warfare agents. 61
32579218 2020
4
Vault changes after cyclopentolate instillation in eyes with posterior chamber phakic intraocular lens. 61
32541775 2020
5
Effect of cyclopentolate versus tropicamide on anterior segment angle parameters in three refractive groups. 61
32519368 2020
6
Defocus Incorporated Multiple Segments Spectacle Lenses Changed the Relative Peripheral Refraction: A 2-Year Randomized Clinical Trial. 61
32460315 2020
7
Lower sensitivity to peripheral hypermetropic defocus due to higher order ocular aberrations. 61
32031730 2020
8
Refractive status and optical components of premature babies with or without retinopathy of prematurity at 7 years old. 61
32477910 2020
9
Comparison of open-field autorefraction, closed-field autorefraction, and retinoscopy for refractive measurements of children and adolescents in Taiwan. 61
32354691 2020
10
The Effect of Topical Cyclopentolate on Anterior Segment Parameters in Patients with Keratoconus 61
32167060 2020
11
[The performance of visual photoscreening for Chinese preschool children aged 4 to 5 years]. 61
32187947 2020
12
Effect of topical pilocarpine on refractive surgery outcomes. 61
31758508 2020
13
National consensus statement regarding pediatric eye examination, refraction, and amblyopia management. 61
31957721 2020
14
Bifocals reduce strabismus in children with Down syndrome: Evidence from a randomized controlled trial. 61
31313886 2020
15
Higher-Order Aberrations and Axial Elongation in Myopic Children Treated With Orthokeratology. 61
32068792 2020
16
The Impact of Parental Rural-to-urban Migration on Children's Refractive Error in Rural China: A Propensity Score Matching Analysis. 61
31610685 2020
17
Measuring changes in Schlemm's canal and trabecular meshwork in different accommodation states in myopia children: an observational study. 61
31399701 2020
18
Associations Between Screen Exposure in Early Life and Myopia amongst Chinese Preschoolers. 61
32046062 2020
19
Association between serum 25-hydroxyvitamin D levels and myopia in general Korean adults. 61
31856458 2020
20
A computational analysis of retinal image quality in eyes with keratoconus. 61
31992755 2020
21
Clinical Manifestations, Diagnosis, and Surgery of Inferior Oblique Muscle Ectopia. 61
32377415 2020
22
Anterior Segment Biometry During Accommodation and Effects of Cycloplegics by Swept-Source Optical Coherence Tomography. 61
32440090 2020
23
Accommodation response and spherical aberration during orthokeratology. 61
31720836 2020
24
Correlation between higher-order aberrations and visual acuity recovery (CoHORT) after spectacles treatment for pediatric refractive amblyopia: A pilot study using iDesign measurement. 61
32059018 2020
25
Refraction under general anesthesia in children, using cycloplegic refraction only as a reference. 61
31985321 2020
26
Effect of Pupil Dilation with Tropicamide on Retinal Vascular Caliber. 61
31267797 2019
27
Permavision intracorneal inlay after sixteen years. Regression of initial refractive hyperopia. 61
31812505 2019
28
COMPLICATIONS OF SERIAL ANTERIOR CHAMBER PARACENTESIS FOR INCREASED INTRAOCULAR PRESSURE AFTER INTRAVITREAL INJECTIONS. 61
31688671 2019
29
Differences in ocular biometry between urban and rural children matched by refractive error: the Shandong Children Eye Study. 61
31696541 2019
30
Two-dimensional Peripheral Refraction and Retinal Image Quality in Emmetropic Children. 61
31700132 2019
31
Agreement and Repeatability of Noncycloplegic and Cycloplegic Wavefront-based Autorefraction in Children. 61
31703049 2019
32
Axial length elongation in primary school-age children: a 3-year cohort study in Shanghai. 61
31676647 2019
33
Central corneal thickness and corneal diameter in preterm and term newborns and preterm neonates at term. 61
31546483 2019
34
Validation of an Affordable Handheld Wavefront Autorefractor. 61
31592955 2019
35
The effect of cycloplegia on biometric measurements using swept-source optical coherence tomography-based biometry. 61
30834574 2019
36
The Effect of Cycloplegia on the Ocular Biometric and Anterior Segment Parameters: A Cross-Sectional Study. 61
31054123 2019
37
Using Decision Curve Analysis to Evaluate Common Strategies for Myopia Screening in School-Aged Children. 61
31094286 2019
38
[Emphasizing the standardized use of cycloplegics in the epidemiological studies of myopia]. 61
31422633 2019
39
Risk factors for high myopia: a 22-year follow-up study from childhood to adulthood. 61
30460746 2019
40
Meeting the need for corrective spectacles in visually impaired Chinese school children: the potential of ready-made spectacles. 61
30279277 2019
41
Prolonged ocular exposure leads to retinal lesions in mice. 61
31128100 2019
42
[An investigation on professional performance of optometric refraction in spectacles stores in Anyang city of Henan Province]. 61
31422635 2019
43
Comparison of retinoscopy results with and without 1% cyclopentolate in school-aged children. 61
31236978 2019
44
Elucidation of the more myopic eye in anisometropia: the interplay of laterality, ocular dominance, and anisometropic magnitude. 61
31270453 2019
45
Factors Affecting Pupil Reactivity After Cycloplegia in Asian Children. 61
31385819 2019
46
Disordered sleep and myopia among adolescents: a propensity score matching analysis. 61
30601071 2019
47
Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial. 61
30367541 2019
48
Unilateral accommodation spasm: Case report and literature review. 61
30837173 2019
49
Distribution of scleral thickness and associated factors in 810 Chinese children and adolescents: a swept-source optical coherence tomography study. 61
30178606 2019
50
Retinal oxygen saturation in 1461 healthy children aged 7-19 and its associated factors. 61
30714353 2019

Variations for Cycloplegia

Expression for Cycloplegia

Search GEO for disease gene expression data for Cycloplegia.

Pathways for Cycloplegia

Pathways related to Cycloplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.1 NBL1 GREM2 GREM1
2
Show member pathways
10.66 GREM2 GREM1 CER1

GO Terms for Cycloplegia

Cellular components related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 SFTA3 NBL1 GREM2 GREM1 DPT CTSC

Biological processes related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.54 NBL1 GREM2 GREM1
2 negative regulation of BMP signaling pathway GO:0030514 9.46 NBL1 GREM2 GREM1 CER1
3 cell development GO:0048468 9.4 IRX6 IRX3
4 negative regulation of monocyte chemotaxis GO:0090027 9.32 NBL1 GREM1
5 sequestering of BMP in extracellular matrix GO:0035582 9.26 NBL1 CER1
6 sequestering of BMP from receptor via BMP binding GO:0038098 9.13 NBL1 GREM2 GREM1
7 determination of dorsal identity GO:0048263 8.92 NBL1 GREM2 GREM1 CER1

Molecular functions related to Cycloplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor ligand activity GO:0048018 9.33 NBL1 GREM2 GREM1
2 morphogen activity GO:0016015 9.13 NBL1 GREM1 CER1
3 BMP binding GO:0036122 8.92 NBL1 GREM2 GREM1 CER1

Sources for Cycloplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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