MCID: CYC005
MIFTS: 41

Cyclothymic Disorder

Categories: Mental diseases

Aliases & Classifications for Cyclothymic Disorder

MalaCards integrated aliases for Cyclothymic Disorder:

Name: Cyclothymic Disorder 12 43 15 71
Cyclothymia 12 74 32
Affective Personality Disorder 12
Cyclothymic Personality 12
Cycloid Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:845
MeSH 43 D003527
SNOMED-CT 67 14697007 76105009
ICD10 32 F34.0
UMLS 71 C0010598

Summaries for Cyclothymic Disorder

Disease Ontology : 12 A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes.

MalaCards based summary : Cyclothymic Disorder, also known as cyclothymia, is related to avoidant personality disorder and personality disorder. An important gene associated with Cyclothymic Disorder is LAMB2 (Laminin Subunit Beta 2), and among its related pathways/superpathways are Monoamine GPCRs and Methylphenidate Pathway, Pharmacodynamics. The drugs Dopamine and Cocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and eye, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 74 Cyclothymia, also known as cyclothymic disorder, is a mental disorder that involves numerous periods of... more...

Related Diseases for Cyclothymic Disorder

Diseases related to Cyclothymic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 30.4 PIR DRD4 DRD2
2 personality disorder 30.1 HTR2A DRD4 DRD2
3 dysthymic disorder 29.9 PIR HTR2A CGAS
4 bipolar i disorder 29.9 HTR2A DRD4 DRD2
5 bulimia nervosa 29.5 HTR2A DRD4 DRD2
6 major depressive disorder 29.5 HTR2A DRD4 DRD2 DISC1
7 phobic disorder 29.4 RTN4 PIR HTR2A CGAS
8 alcohol use disorder 29.3 RTN4 HTR2A DRD2
9 mental depression 29.1 RTN4 HTR2A DRD4 DRD2 DISC1
10 panic disorder 28.8 HTR2A DRD4 DRD2 DAOA
11 mood disorder 28.8 HTR2A DRD4 DRD2 DISC1 DAOA
12 bipolar disorder 28.4 RTN4 HTR2A DRD4 DRD2 DISC1 DAOA
13 schizotypal personality disorder 28.3 PIR DRD4 DRD2 DISC1 DAOA
14 psychotic disorder 27.8 RTN4 HTR2A DRD4 DRD2 DISC1 DAOA
15 schizophrenia 27.6 RTN4 HTR2A DRD4 DRD2 DISC1 DAOA
16 major affective disorder 8 10.5
17 major affective disorder 9 10.5
18 depression 10.3
19 schizophrenia 2 10.3 DISC1FP1 DISC1
20 endogenous depression 10.2
21 major affective disorder 1 10.2
22 agoraphobia 10.2
23 idiopathic corneal edema 10.2 DRD4 DRD2
24 periodic limb movement disorder 10.1 DRD4 DRD2
25 paraphilia disorder 10.1 RTN4 PIR
26 lingual-facial-buccal dyskinesia 10.1 DRD4 DRD2
27 schizoid personality disorder 10.1 PIR DRD2 DISC1
28 chronic tic disorder 10.1 DRD4 DRD2
29 pyromania 10.0 RTN4 DRD2
30 obsessive-compulsive personality disorder 10.0 PIR HTR2A
31 colitis 10.0
32 dystonia 10.0
33 ulcerative colitis 10.0
34 kleptomania 10.0 RTN4 DRD2
35 alcohol dependence 10.0
36 anxiety 10.0
37 crohn's colitis 10.0
38 physical disorder 10.0
39 atypical depressive disorder 10.0
40 dementia 10.0
41 epilepsy 10.0
42 melancholia 10.0
43 pustulosis of palm and sole 10.0
44 severe combined immunodeficiency 10.0
45 premenstrual tension 10.0
46 eating disorder 10.0
47 crohn's disease 10.0
48 psoriasis 10.0
49 mixed cerebral palsy 10.0 DRD4 DRD2
50 adjustment disorder 10.0 LAMB2 HTR2A CGAS

Comorbidity relations with Cyclothymic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Cyclothymic Disorder:



Diseases related to Cyclothymic Disorder

Symptoms & Phenotypes for Cyclothymic Disorder

MGI Mouse Phenotypes related to Cyclothymic Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 CADPS2 CGAS CNTN5 CNTNAP3 DISC1 DRD2
2 nervous system MP:0003631 9.32 CADPS2 CNTN5 CNTNAP3 DISC1 DRD2 DRD4

Drugs & Therapeutics for Cyclothymic Disorder

Drugs for Cyclothymic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
3
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
4
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
5
Metformin Approved Phase 4 657-24-9 4091 14219
6
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
7
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
8
Ethanol Approved Phase 4 64-17-5 702
9
Ondansetron Approved Phase 4 99614-02-5 4595
10
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
11
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
12
Cobalamin Experimental Phase 4 13408-78-1 6857388
13 Antimanic Agents Phase 4
14 Anesthetics, Local Phase 4
15 Hormones Phase 4
16 Dopamine Agents Phase 4
17 Anticonvulsants Phase 4
18 Anesthetics Phase 4
19 Sodium Channel Blockers Phase 4
20 Dopamine Uptake Inhibitors Phase 4
21 Diuretics, Potassium Sparing Phase 4
22 Calcium, Dietary Phase 4
23 Vasoconstrictor Agents Phase 4
24 calcium channel blockers Phase 4
25 GABA Agents Phase 4
26 Vitamin B 12 Phase 4
27 Vitamins Phase 4
28 Vitamin B Complex Phase 4
29 Insulin, Globin Zinc Phase 4
30 Vitamin B12 Phase 4
31 insulin Phase 4
32 Hypoglycemic Agents Phase 4
33 Gastrointestinal Agents Phase 4
34 Antiemetics Phase 4
35 Tranquilizing Agents Phase 4
36 Neurotransmitter Agents Phase 4
37 Antipsychotic Agents Phase 4
38 Psychotropic Drugs Phase 4
39 Serotonin Agents Phase 4
40 Dermatologic Agents Phase 4
41 Autonomic Agents Phase 4
42 Central Nervous System Depressants Phase 4
43 Serotonin Antagonists Phase 4
44 Anti-Infective Agents Phase 4
45 Anti-Infective Agents, Local Phase 4
46 Antipruritics Phase 4
47 Anti-Anxiety Agents Phase 4
48
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
49 Antidepressive Agents Phase 3
50 Quetiapine Fumarate Phase 3 111974-72-2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled, Trial of Lamotrigine add-on Therapy in Outpatients With Bipolar Disorder, Depressed or Mixed Phase and Cocaine Dependence Completed NCT00280293 Phase 4 Lamotrigine;Placebo
2 Double Blind Placebo Controlled Study of Depakote (Divalproex Sodium) in Children With Temper Outbursts and Severe Mood Swings Completed NCT02078596 Phase 4 Divalproex
3 MOBILITY- Metformin for Overweight & OBese ChILdren and Adolescents With BIpolar Spectrum Disorders Treated With Second-Generation AntipsYchotics Recruiting NCT02515773 Phase 4 Metformin
4 Ondansetron for Bipolar Disorder and Alcohol Use Disorders Active, not recruiting NCT02082678 Phase 4 Ondansetron;Placebo
5 Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders: An Open Prospective Longitudinal Study of the Effectiveness of Quetiapine Monotherapy in Preventing Relapse and Minimizing Neurocognitive Dysfunction Among Adolescents Manifesting Bipolar Spectrum Disorders Completed NCT00252226 Phase 3 Quetiapine
6 A Single-Blind Prospective Study of Quetiapine for the Treatment of Mood Disorders in Adolescents Completed NCT00221468 Phase 3 quetiapine
7 Bipolar Disorder With Alcoholism in Han Chinese Unknown status NCT01188395
8 Calling for Care: Cell Phones for Mood Telemetry Completed NCT01083823
9 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
10 Pilot Randomized Controlled Trial to Evaluate the Efficacy of Well-Being Therapy vs a Control Condition in Chronic Migraine Patients Recruiting NCT03404336
11 Epilepsy and Mood Regulation Disorders: a Prospective and Longitudinal Study in Children With Newly Diagnosed Epilepsy Recruiting NCT02568813
12 Early Intervention for Youth at Risk for Bipolar Disorder Active, not recruiting NCT01483391
13 Emotional Dysregulation and Cyclothymia in Adult Patients With ADHD: Cohort Follow-up of Patients in Two Referral Centers Not yet recruiting NCT03494478

Search NIH Clinical Center for Cyclothymic Disorder

Cochrane evidence based reviews: cyclothymic disorder

Genetic Tests for Cyclothymic Disorder

Anatomical Context for Cyclothymic Disorder

MalaCards organs/tissues related to Cyclothymic Disorder:

40
Brain, Thyroid, Eye, Heart

Publications for Cyclothymic Disorder

Articles related to Cyclothymic Disorder:

(show top 50) (show all 381)
# Title Authors PMID Year
1
Validation of the brief TEMPS-M temperament questionnaire in a clinical Italian sample of bipolar and cyclothymic patients. 61
31539680 2020
2
Genetic analysis of activity, brain and behavioral associations in extended families with heavy genetic loading for bipolar disorder. 61
31813409 2019
3
Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset. 61
31733039 2019
4
Reactivity, Intensity, Polarity and Stability questionnaire (RIPoSt-40) assessing emotional dysregulation: Development, reliability and validity. 61
31301622 2019
5
Fake views: Cyclothymia - A dithering disorder? 61
31401865 2019
6
[Disorders of the anxiety-depressive spectrum in inflammatory bowel diseases (psychosomatic correlations)]. 61
31156215 2019
7
Not All Masks Are Created Equal: Masking Success in Clinical Trials of Children and Adolescents. 61
28715242 2019
8
Parsing cyclothymic disorder and other specified bipolar spectrum disorders in youth. 61
29909300 2018
9
Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study. 61
30198055 2018
10
Does recent mania affect response to antidepressants in bipolar disorder? A re-analysis of STEP-BD data. 61
29734096 2018
11
Omega-3 supplementation associated with improved parent-rated executive function in youth with mood disorders: secondary analyses of the omega 3 and therapy (OATS) trials. 61
29063592 2018
12
The role of lifetime anxiety history in the course of bipolar spectrum disorders. 61
29653349 2018
13
Measuring racing thoughts in healthy individuals: The Racing and Crowded Thoughts Questionnaire (RCTQ). 61
29407357 2018
14
Temperament in Adulthood Attention Deficit-Hyperactivity Disorder without Bipolar Disorder. 61
29475238 2018
15
Cognitive deficits in bipolar disorders: Implications for emotion. 61
29195773 2018
16
[The facets of creativity in the light of bipolar mood alterations]. 61
29465902 2018
17
Examining the Feasibility and Acceptability of an Online Yoga Class for Mood Disorders: A MoodNetwork Study. 61
29320386 2018
18
A Double-Blind and Placebo-Controlled Trial of Aripiprazole in Symptomatic Youths at Genetic High Risk for Bipolar Disorder. 61
28759262 2017
19
Psychophysiological characteristics in the ChNPP accident clean-up workers, exclusion zone evacuees and anti-terrorist operation servicemen. 61
29286524 2017
20
A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder. 61
28731778 2017
21
Clinical stabilisation with lacosamide of mood disorder comorbid with PTSD and fronto-temporal epilepsy. 61
28845834 2017
22
Bipolar At-Risk Criteria: An Examination of Which Clinical Features Have Optimal Utility for Identifying Youth at Risk of Early Transition From Depression to Bipolar Disorders. 61
27872258 2017
23
Longitudinal course and characteristics of cyclothymic disorder in youth. 61
28365522 2017
24
A Peep Into "Peeping Tom": Successful Management of Cyclothymia Presenting as Voyeuristic Disorder. 61
28617564 2017
25
Aggression Protects Against the Onset of Major Depressive Episodes in Individuals With Bipolar Spectrum Disorder. 61
28390495 2017
26
Kindling of Life Stress in Bipolar Disorder: Effects of Early Adversity. 61
28390496 2017
27
Personality disorder symptom severity predicts onset of mood episodes and conversion to bipolar I disorder in individuals with bipolar spectrum disorder. 61
28368159 2017
28
Diagnosis and Treatment of Cyclothymia: The "Primacy" of Temperament. 61
28503108 2017
29
Drug-induced parkinsonism: A case report. 61
29955500 2017
30
Pathological personality development after the Chornobyl disaster and the anti terrorist operation. 61
28027557 2016
31
Alcohol consumption and accentuated personality traits among young adults in Romania: a cross-sectional study. 61
27784325 2016
32
Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Bipolar Disorder: A Review of Biomarker and Treatment Studies. 61
27631140 2016
33
Bipolar disorder: clinical overview. 61
29956510 2016
34
The Treatment of Adult Bipolar Disorder with Aripiprazole: A Systematic Review. 61
27190727 2016
35
Temperaments in completed suicides: Are they different from those in suicide attempters and controls? 61
26773996 2016
36
Impact of Irritability and Impulsive Aggressive Behavior on Impairment and Social Functioning in Youth with Cyclothymic Disorder. 61
26835744 2016
37
Demoralization and Response to Psychotherapy: A Pilot Study Comparing the Sequential Combination of Cognitive-Behavioral Therapy and Well-Being Therapy with Clinical Management in Cyclothymic Disorder. 61
26609700 2016
38
A Randomized Controlled Trial of Individual Family Psychoeducational Psychotherapy and Omega-3 Fatty Acids in Youth with Subsyndromal Bipolar Disorder. 61
26682997 2015
39
Cyclothymia reloaded: A reappraisal of the most misconceived affective disorder. 61
26005206 2015
40
Precursors of bipolar disorders: a systematic literature review of prospective studies. 61
26035191 2015
41
Anxiety comorbidity in bipolar spectrum disorders: the mediational role of perfectionism in prospective depressive symptoms. 61
25499686 2015
42
Negative cognitive styles synergistically predict suicidal ideation in bipolar spectrum disorders: a 3-year prospective study. 61
25660736 2015
43
Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. 61
25462111 2015
44
General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. 61
25237732 2015
45
Georg Friedrich Händel: a case of large vessel disease with complications in the eighteenth century. 61
25684296 2015
46
[Treatment of endogenous depression with venflaxine: clinical action, tolerability and personalized treatment options]. 61
25909806 2015
47
Temperamental differences between bipolar disorder, borderline personality disorder, and attention deficit/hyperactivity disorder: some implications for their diagnostic validity. 61
25173432 2014
48
Affective temperaments and neurocognitive functioning in bipolar disorder. 61
25151191 2014
49
Clinical course of the bipolar II disorder in a Japanese sample. 61
25103632 2014
50
Characterization of patients with mood disorders for their prevalent temperament and level of hopelessness. 61
25012443 2014

Variations for Cyclothymic Disorder

Expression for Cyclothymic Disorder

Search GEO for disease gene expression data for Cyclothymic Disorder.

Pathways for Cyclothymic Disorder

Pathways related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.84 HTR2A DRD4 DRD2
2
Show member pathways
10.32 DRD4 DRD2

GO Terms for Cyclothymic Disorder

Cellular components related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 8.92 HTR2A DRD4 DRD2 CADPS2

Biological processes related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of dopamine secretion GO:0014059 9.57 HTR2A DRD2
2 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.56 HTR2A DRD4
3 arachidonic acid secretion GO:0050482 9.55 DRD4 DRD2
4 positive regulation of neuroblast proliferation GO:0002052 9.54 DRD2 DISC1
5 negative regulation of protein secretion GO:0050709 9.52 DRD4 DRD2
6 temperature homeostasis GO:0001659 9.51 HTR2A DRD2
7 dopamine receptor signaling pathway GO:0007212 9.49 DRD4 DRD2
8 positive regulation of kinase activity GO:0033674 9.48 HTR2A DRD4
9 synaptic transmission, dopaminergic GO:0001963 9.46 DRD4 DRD2
10 negative regulation of voltage-gated calcium channel activity GO:1901386 9.43 DRD4 DRD2
11 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.4 HTR2A DRD2
12 behavioral response to ethanol GO:0048149 9.37 DRD4 DRD2
13 dopamine metabolic process GO:0042417 9.32 DRD4 DRD2
14 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.26 DRD4 DRD2
15 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.16 DRD4 DRD2
16 response to histamine GO:0034776 8.96 DRD4 DRD2
17 behavioral response to cocaine GO:0048148 8.8 HTR2A DRD4 DRD2

Molecular functions related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopamine binding GO:0035240 9.26 DRD4 DRD2
2 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.16 DRD4 DRD2
3 drug binding GO:0008144 9.13 HTR2A DRD4 DRD2
4 dopamine neurotransmitter receptor activity GO:0004952 8.62 DRD4 DRD2

Sources for Cyclothymic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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