MCID: CYC005
MIFTS: 29

Cyclothymic Disorder

Categories: Mental diseases

Aliases & Classifications for Cyclothymic Disorder

MalaCards integrated aliases for Cyclothymic Disorder:

Name: Cyclothymic Disorder 12 45 15 74
Cyclothymia 12 77
Affective Personality Disorder 12
Cyclothymic Personality 12
Cycloid Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:845
MeSH 45 D003527
SNOMED-CT 69 14697007 76105009
ICD10 34 F34.0
UMLS 74 C0010598

Summaries for Cyclothymic Disorder

Disease Ontology : 12 A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes.

MalaCards based summary : Cyclothymic Disorder, also known as cyclothymia, is related to dysthymic disorder and depression. An important gene associated with Cyclothymic Disorder is CNTNAP3 (Contactin Associated Protein Like 3). The drugs Ondansetron and Ethanol have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Cyclothymia, also known as cyclothymic disorder, is a mental disorder that involves periods of symptoms... more...

Related Diseases for Cyclothymic Disorder

Diseases related to Cyclothymic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 dysthymic disorder 10.2
2 depression 10.2
3 major affective disorder 4 10.1
4 major affective disorder 8 10.1
5 major affective disorder 7 10.1
6 major affective disorder 9 10.1
7 bipolar disorder 10.1
8 mood disorder 10.1
9 ulcerative colitis 10.0
10 colitis 10.0
11 personality disorder 10.0
12 alcohol dependence 9.9
13 anxiety 9.9
14 borderline personality disorder 9.9
15 atypical depressive disorder 9.9
16 agoraphobia 9.9
17 panic disorder 9.9
18 premenstrual tension 9.9
19 schizophrenia 9.7

Comorbidity relations with Cyclothymic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Cyclothymic Disorder:



Diseases related to Cyclothymic Disorder

Symptoms & Phenotypes for Cyclothymic Disorder

GenomeRNAi Phenotypes related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.23 ALDH1B1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.23 PIR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.23 ALDH1B1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.23 PIR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.23 ALDH1B1 PIR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.23 PIR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.23 ALDH1B1

Drugs & Therapeutics for Cyclothymic Disorder

Drugs for Cyclothymic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 4 99614-02-5 4595
2
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
3 Anti-Infective Agents, Local Phase 4
4 Central Nervous System Depressants Phase 4,Phase 3
5 Peripheral Nervous System Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Autonomic Agents Phase 4
8 Psychotropic Drugs Phase 4,Phase 3
9 Neurotransmitter Agents Phase 4
10 Serotonin Agents Phase 4
11 Serotonin Antagonists Phase 4
12 Anti-Anxiety Agents Phase 4
13 Antipsychotic Agents Phase 4,Phase 3
14 Antiemetics Phase 4
15 Antipruritics Phase 4
16 Dermatologic Agents Phase 4
17 Gastrointestinal Agents Phase 4
18 Tranquilizing Agents Phase 4,Phase 3
19
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
20 Quetiapine Fumarate Phase 3 111974-72-2
21 Antidepressive Agents Phase 3
22
Sertraline Approved 79617-96-2 68617
23
Medroxyprogesterone acetate Approved, Investigational 71-58-9
24
Levonorgestrel Approved, Investigational 17489-40-6, 797-63-7 13109
25
Lithium carbonate Approved 554-13-2
26 Neurotransmitter Uptake Inhibitors
27 Antimanic Agents
28 Contraceptives, Oral
29 Contraceptive Agents
30 Serotonin Uptake Inhibitors
31
Medroxyprogesterone 520-85-4 10631
32 Contraceptives, Oral, Combined

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ondansetron for Bipolar Disorder and Alcohol Use Disorders Completed NCT02082678 Phase 4 Ondansetron;Placebo
2 Early Intervention for Youth at Risk for Bipolar Disorder Unknown status NCT01483391 Phase 2, Phase 3
3 Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders Completed NCT00252226 Phase 3 Quetiapine
4 Calling for Care: Cell Phones for Mood Telemetry in Teens Completed NCT01083823 Not Applicable
5 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
6 Epilepsy and Mood Regulation Disorder in Children Recruiting NCT02568813 Not Applicable
7 Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy Recruiting NCT03404336 Not Applicable
8 Emotional Dysregulation in Adult ADHD. Not yet recruiting NCT03494478 Not Applicable

Search NIH Clinical Center for Cyclothymic Disorder

Cochrane evidence based reviews: cyclothymic disorder

Genetic Tests for Cyclothymic Disorder

Anatomical Context for Cyclothymic Disorder

Publications for Cyclothymic Disorder

Articles related to Cyclothymic Disorder:

(show all 44)
# Title Authors Year
1
Parsing cyclothymic disorder and other specified bipolar spectrum disorders in youth. ( 29909300 )
2018
2
Longitudinal course and characteristics of cyclothymic disorder in youth. ( 28365522 )
2017
3
Diagnosis and Treatment of Cyclothymia: The "Primacy" of Temperament. ( 28503108 )
2017
4
A Peep Into "Peeping Tom": Successful Management of Cyclothymia Presenting as Voyeuristic Disorder. ( 28617564 )
2017
5
Demoralization and Response to Psychotherapy: A Pilot Study Comparing the Sequential Combination of Cognitive-Behavioral Therapy and Well-Being Therapy with Clinical Management in Cyclothymic Disorder. ( 26609700 )
2016
6
Impact of Irritability and Impulsive Aggressive Behavior on Impairment and Social Functioning in Youth with Cyclothymic Disorder. ( 26835744 )
2016
7
Cyclothymia reloaded: A reappraisal of the most misconceived affective disorder. ( 26005206 )
2015
8
Examining the validity of cyclothymic disorder in a youth sample: replication and extension. ( 22968491 )
2013
9
Cyclothymic disorder in youth: why is it overlooked, what do we know and where is the field headed? ( 23544035 )
2012
10
Cyclothymic disorder: a critical review. ( 22459786 )
2012
11
Cognitive behavioural therapy for cyclothymia: cognitive regulatory control as a mediator of mood change. ( 22353188 )
2012
12
Cyclothymia. ( 22553122 )
2012
13
Examining the validity of cyclothymic disorder in a youth sample. ( 21396717 )
2011
14
The sequential combination of cognitive behavioral treatment and well-being therapy in cyclothymic disorder. ( 21372621 )
2011
15
Treatment of cyclothymic disorder: commentary. ( 21372620 )
2011
16
Impulsivity in anxiety disorder patients: is it related to comorbid cyclothymia? ( 21665290 )
2011
17
Possible testable correlations between passive smoking and bipolar/cyclothymic disorder, depression and ADD/ADHD. ( 20171792 )
2010
18
Did the author of Psalm 30 have cyclothymia or bipolar disorder? ( 19949208 )
2009
19
Dissociative experiences differentiate bipolar-II from unipolar depressed patients: the mediating role of cyclothymia and the Type A behaviour speed and impatience subscale. ( 18077000 )
2008
20
Restructuring mood in cyclothymia using cognitive behavior therapy: an intensive time-sampling study. ( 18324665 )
2008
21
Cyclothymia and labile personality: is all folie circulaire? ( 16427135 )
2006
22
The role of cyclothymia in atypical depression: toward a data-based reconceptualization of the borderline-bipolar II connection. ( 12507741 )
2003
23
Factor structure of hypomania: interrelationships with cyclothymia and the soft bipolar spectrum. ( 12507736 )
2003
24
Dysthymia and cyclothymia in psychiatric practice a century after Kraepelin. ( 11172870 )
2001
25
Seasonal cyclothymia to seasonal bipolar affective disorder: a double switch after stroke. ( 9416820 )
1997
26
Dysthymia and cyclothymia: historical origins and contemporary development. ( 9298424 )
1997
27
A comprehensive review of cyclothymic disorder. ( 8360639 )
1993
28
Low-dose valproate: a new treatment for cyclothymia, mild rapid cycling disorders, and premenstrual syndrome. ( 8331092 )
1993
29
Proposed subtypes of bipolar II and related disorders: with hypomanic episodes (or cyclothymia) and with hyperthymic temperament. ( 1447430 )
1992
30
Cyclothymia and the kindling hypothesis. ( 2343938 )
1990
31
The prevalence of cyclothymia in borderline personality disorder. ( 2380158 )
1990
32
The relation between rapid-cycling cyclothymia and bulimia; case reports of two women. ( 3375804 )
1988
33
Cyclothymic disorder and bromocriptine: predisposing factors for postpartum mania? ( 3690486 )
1987
34
Inventory identification of cyclothymia. IX. Validation in offspring of bipolar I patients. ( 3964023 )
1986
35
Ulcerative colitis: a cyclothymic disorder? ( 4059488 )
1985
36
Cyclothymia in the adolescent offspring of parents with bipolar affective disorder. ( 3998280 )
1985
37
Behavioral response to naturally occurring stress in cyclothymia and dysthymia. ( 3998281 )
1985
38
Cyclothymic disorder as bipolar illness. ( 665861 )
1978
39
Classification of cyclothymic disorder. ( 637158 )
1978
40
Cyclothymic disorder: validating criteria for inclusion in the bipolar affective group. ( 910973 )
1977
41
The kybernetics of cyclothymia. ( 5893239 )
1965
42
Schizothymia-cyclothymia as a dimension of personality. II. Experimental. ( 14939139 )
1952
43
Cyclothymia and schizothymia as a dimension of personality. I. Historical review. ( 14814596 )
1950
44
What correlation is there between hysteria and cyclothymia or schizothymia? ( 18103774 )
1948

Variations for Cyclothymic Disorder

Expression for Cyclothymic Disorder

Search GEO for disease gene expression data for Cyclothymic Disorder.

Pathways for Cyclothymic Disorder

GO Terms for Cyclothymic Disorder

Sources for Cyclothymic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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