MCID: CYC005
MIFTS: 40

Cyclothymic Disorder

Categories: Mental diseases

Aliases & Classifications for Cyclothymic Disorder

MalaCards integrated aliases for Cyclothymic Disorder:

Name: Cyclothymic Disorder 12 43 15 71
Cyclothymia 12 74 32
Affective Personality Disorder 12
Cyclothymic Personality 12
Cycloid Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:845
ICD9CM 34 301.13
MeSH 43 D003527
SNOMED-CT 67 386798001
ICD10 32 F34.0
UMLS 71 C0010598

Summaries for Cyclothymic Disorder

Disease Ontology : 12 A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes.

MalaCards based summary : Cyclothymic Disorder, also known as cyclothymia, is related to avoidant personality disorder and dysthymic disorder. An important gene associated with Cyclothymic Disorder is LAMB2 (Laminin Subunit Beta 2), and among its related pathways/superpathways are Monoamine GPCRs and Methylphenidate Pathway, Pharmacodynamics. The drugs Lamotrigine and Cocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 74 Cyclothymia, also known as cyclothymic disorder, is a mental disorder that involves numerous periods of... more...

Related Diseases for Cyclothymic Disorder

Diseases related to Cyclothymic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 30.8 PIR DRD4
2 dysthymic disorder 30.1 PIR HTR2A CGAS
3 agoraphobia 30.0 PIR HTR2A COMT
4 personality disorder 29.9 HTR2A DRD4 DRD2 COMT
5 bipolar i disorder 29.7 HTR2A DRD4 DRD2 COMT
6 eating disorder 29.7 HTR2A DRD2 COMT
7 alcohol use disorder 29.7 HTR2A DRD2 COMT
8 major depressive disorder 29.5 HTR2A DRD4 DRD2 DISC1 COMT
9 mental depression 29.5 HTR2A DRD4 DRD2 DISC1 COMT
10 bipolar disorder 29.4 HTR2A DRD4 DRD2 DISC1 DAOA COMT
11 bulimia nervosa 29.4 HTR2A DRD4 DRD2 COMT
12 anxiety 29.3 HTR2A DRD4 DRD2 COMT
13 phobic disorder 29.3 PIR HTR2A DRD2 COMT CGAS
14 panic disorder 29.3 HTR2A DRD4 DRD2 DAOA COMT
15 alcohol dependence 29.2 HTR2A DRD4 DRD2 COMT
16 borderline personality disorder 29.2 HTR2A DRD2 COMT
17 mood disorder 29.2 HTR2A DRD4 DRD2 DISC1 DAOA COMT
18 psychotic disorder 28.8 HTR2A DRD4 DRD2 DISC1 DAOA COMT
19 schizophrenia 28.8 HTR2A DRD4 DRD2 DISC1 DAOA COMT
20 schizotypal personality disorder 28.6 PIR DRD4 DRD2 DISC1 DAOA COMT
21 major affective disorder 8 10.5
22 major affective disorder 9 10.5
23 paranoid personality disorder 10.4 PIR DISC1
24 schizophrenia 2 10.3 DISC1FP1 DISC1
25 depression 10.3
26 dependent personality disorder 10.3 PIR DRD4
27 endogenous depression 10.3
28 kleptomania 10.2 DRD4 DRD2
29 oculogyric crisis 10.2 DRD4 DRD2
30 separation anxiety disorder 10.2 DRD4 CGAS
31 schizoid personality disorder 10.2 PIR DRD2 DISC1
32 polysubstance abuse 10.2 DRD2 COMT
33 major affective disorder 1 10.2
34 chronic tic disorder 10.1 DRD4 DRD2 CGAS
35 traumatic brain injury 10.1 DRD2 COMT
36 brain injury 10.1 DRD2 COMT
37 opioid addiction 10.1 DRD2 COMT
38 adjustment disorder 10.1 LAMB2 HTR2A CGAS
39 night blindness, congenital stationary, type 1h 10.1 DRD4 DRD2
40 hypochondriasis 10.1 PIR HTR2A
41 hallucinogen dependence 10.1 DRD2 COMT
42 opioid abuse 10.1 DRD4 DRD2
43 phobia, specific 10.1 COMT CGAS
44 social phobia 10.0 DRD2 COMT CGAS
45 body dysmorphic disorder 10.0 PIR HTR2A
46 colitis 10.0
47 dystonia 10.0
48 ulcerative colitis 10.0
49 crohn's colitis 10.0
50 physical disorder 10.0

Comorbidity relations with Cyclothymic Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Cyclothymic Disorder:



Diseases related to Cyclothymic Disorder

Symptoms & Phenotypes for Cyclothymic Disorder

MGI Mouse Phenotypes related to Cyclothymic Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 CADPS2 CGAS CNTN5 CNTNAP3 COMT DISC1
2 nervous system MP:0003631 9.32 CADPS2 CNTN5 CNTNAP3 COMT DISC1 DRD2

Drugs & Therapeutics for Cyclothymic Disorder

Drugs for Cyclothymic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
2
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
3
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
4
Metformin Approved Phase 4 657-24-9 14219 4091
5
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
6
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
7
Ondansetron Approved Phase 4 99614-02-5 4595
8
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
9
Cobalamin Experimental Phase 4 13408-78-1 6857388
10 Psychotropic Drugs Phase 4
11 Hormones Phase 4
12 Sodium Channel Blockers Phase 4
13 Diuretics, Potassium Sparing Phase 4
14 Anticonvulsants Phase 4
15 Calcium, Dietary Phase 4
16 calcium channel blockers Phase 4
17 Vitamins Phase 4
18 Insulin, Globin Zinc Phase 4
19 Vitamin B Complex Phase 4
20 Vitamin B 12 Phase 4
21 Hypoglycemic Agents Phase 4
22 insulin Phase 4
23 Vitamin B12 Phase 4
24 Anti-Anxiety Agents Phase 4
25 Antiemetics Phase 4
26 Dermatologic Agents Phase 4
27 Antipsychotic Agents Phase 4
28 Gastrointestinal Agents Phase 4
29 Neurotransmitter Agents Phase 4
30
Calcium Nutraceutical Phase 4 7440-70-2 271
31
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
32 Antidepressive Agents Phase 3
33 Quetiapine Fumarate Phase 3 111974-72-2
34
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
35
Sertraline Approved 79617-96-2 68617
36
Medroxyprogesterone acetate Approved, Investigational 71-58-9
37
Lithium carbonate Approved 554-13-2
38
Ethanol Approved 64-17-5 702
39 Contraceptive Agents
40 Contraceptives, Oral, Combined
41 Contraceptives, Oral
42
Medroxyprogesterone 520-85-4 10631

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled, Trial of Lamotrigine add-on Therapy in Outpatients With Bipolar Disorder, Depressed or Mixed Phase and Cocaine Dependence Completed NCT00280293 Phase 4 Lamotrigine;Placebo
2 Double Blind Placebo Controlled Study of Depakote (Divalproex Sodium) in Children With Temper Outbursts and Severe Mood Swings Completed NCT02078596 Phase 4 Divalproex
3 MOBILITY- Metformin for Overweight & OBese ChILdren and Adolescents With BIpolar Spectrum Disorders Treated With Second-Generation AntipsYchotics Recruiting NCT02515773 Phase 4 Metformin
4 Ondansetron for Bipolar Disorder and Alcohol Use Disorders Active, not recruiting NCT02082678 Phase 4 Ondansetron;Placebo
5 Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders: An Open Prospective Longitudinal Study of the Effectiveness of Quetiapine Monotherapy in Preventing Relapse and Minimizing Neurocognitive Dysfunction Among Adolescents Manifesting Bipolar Spectrum Disorders Completed NCT00252226 Phase 3 Quetiapine
6 A Single-Blind Prospective Study of Quetiapine for the Treatment of Mood Disorders in Adolescents Completed NCT00221468 Phase 3 quetiapine
7 Bipolar Disorder With Alcoholism in Han Chinese Unknown status NCT01188395
8 Calling for Care: Cell Phones for Mood Telemetry Completed NCT01083823
9 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
10 Pilot Randomized Controlled Trial to Evaluate the Efficacy of Well-Being Therapy vs a Control Condition in Chronic Migraine Patients Recruiting NCT03404336
11 Epilepsy and Mood Regulation Disorders: a Prospective and Longitudinal Study in Children With Newly Diagnosed Epilepsy Recruiting NCT02568813
12 Early Intervention for Youth at Risk for Bipolar Disorder Active, not recruiting NCT01483391
13 Emotional Dysregulation and Cyclothymia in Adult Patients With ADHD: Cohort Follow-up of Patients in Two Referral Centers Not yet recruiting NCT03494478
14 Randomized Controlled Trial for Testing the Efficacy of Well-Being Therapy in Patients With Systemic Sclerosis Not yet recruiting NCT04212247

Search NIH Clinical Center for Cyclothymic Disorder

Cochrane evidence based reviews: cyclothymic disorder

Genetic Tests for Cyclothymic Disorder

Anatomical Context for Cyclothymic Disorder

MalaCards organs/tissues related to Cyclothymic Disorder:

40
Testes, Brain, Thyroid, Eye, Heart

Publications for Cyclothymic Disorder

Articles related to Cyclothymic Disorder:

(show top 50) (show all 385)
# Title Authors PMID Year
1
The relationship between affective temperament and remission. 61
32558005 2020
2
When and how to use Lithium. 61
32526812 2020
3
Perspective: Aristotle on manic-depressive illness and greatness. 61
32276300 2020
4
[Diagnostics and early recognition of bipolar disorders]. 61
32125440 2020
5
Validation of the brief TEMPS-M temperament questionnaire in a clinical Italian sample of bipolar and cyclothymic patients. 61
31539680 2020
6
Genetic analysis of activity, brain and behavioral associations in extended families with heavy genetic loading for bipolar disorder. 61
31813409 2019
7
Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset. 61
31733039 2019
8
Reactivity, Intensity, Polarity and Stability questionnaire (RIPoSt-40) assessing emotional dysregulation: Development, reliability and validity. 61
31301622 2019
9
Fake views: Cyclothymia - A dithering disorder? 61
31401865 2019
10
[Disorders of the anxiety-depressive spectrum in inflammatory bowel diseases (psychosomatic correlations)]. 61
31156215 2019
11
Not All Masks Are Created Equal: Masking Success in Clinical Trials of Children and Adolescents. 61
28715242 2019
12
Parsing cyclothymic disorder and other specified bipolar spectrum disorders in youth. 61
29909300 2018
13
Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study. 61
30198055 2018
14
Does recent mania affect response to antidepressants in bipolar disorder? A re-analysis of STEP-BD data. 61
29734096 2018
15
The role of lifetime anxiety history in the course of bipolar spectrum disorders. 61
29653349 2018
16
Omega-3 supplementation associated with improved parent-rated executive function in youth with mood disorders: secondary analyses of the omega 3 and therapy (OATS) trials. 61
29063592 2018
17
Measuring racing thoughts in healthy individuals: The Racing and Crowded Thoughts Questionnaire (RCTQ). 61
29407357 2018
18
Temperament in Adulthood Attention Deficit-Hyperactivity Disorder without Bipolar Disorder. 61
29475238 2018
19
Cognitive deficits in bipolar disorders: Implications for emotion. 61
29195773 2018
20
[The facets of creativity in the light of bipolar mood alterations]. 61
29465902 2018
21
Examining the Feasibility and Acceptability of an Online Yoga Class for Mood Disorders: A MoodNetwork Study. 61
29320386 2018
22
A Double-Blind and Placebo-Controlled Trial of Aripiprazole in Symptomatic Youths at Genetic High Risk for Bipolar Disorder. 61
28759262 2017
23
Psychophysiological characteristics in the ChNPP accident clean-up workers, exclusion zone evacuees and anti-terrorist operation servicemen. 61
29286524 2017
24
A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder. 61
28731778 2017
25
Clinical stabilisation with lacosamide of mood disorder comorbid with PTSD and fronto-temporal epilepsy. 61
28845834 2017
26
Bipolar At-Risk Criteria: An Examination of Which Clinical Features Have Optimal Utility for Identifying Youth at Risk of Early Transition From Depression to Bipolar Disorders. 61
27872258 2017
27
Longitudinal course and characteristics of cyclothymic disorder in youth. 61
28365522 2017
28
A Peep Into "Peeping Tom": Successful Management of Cyclothymia Presenting as Voyeuristic Disorder. 61
28617564 2017
29
Aggression Protects Against the Onset of Major Depressive Episodes in Individuals With Bipolar Spectrum Disorder. 61
28390495 2017
30
Kindling of Life Stress in Bipolar Disorder: Effects of Early Adversity. 61
28390496 2017
31
Personality disorder symptom severity predicts onset of mood episodes and conversion to bipolar I disorder in individuals with bipolar spectrum disorder. 61
28368159 2017
32
Diagnosis and Treatment of Cyclothymia: The "Primacy" of Temperament. 61
28503108 2017
33
Drug-induced parkinsonism: A case report. 61
29955500 2017
34
Pathological personality development after the Chornobyl disaster and the anti terrorist operation. 61
28027557 2016
35
Alcohol consumption and accentuated personality traits among young adults in Romania: a cross-sectional study. 61
27784325 2016
36
Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Bipolar Disorder: A Review of Biomarker and Treatment Studies. 61
27631140 2016
37
Bipolar disorder: clinical overview. 61
29956510 2016
38
The Treatment of Adult Bipolar Disorder with Aripiprazole: A Systematic Review. 61
27190727 2016
39
Temperaments in completed suicides: Are they different from those in suicide attempters and controls? 61
26773996 2016
40
Impact of Irritability and Impulsive Aggressive Behavior on Impairment and Social Functioning in Youth with Cyclothymic Disorder. 61
26835744 2016
41
Demoralization and Response to Psychotherapy: A Pilot Study Comparing the Sequential Combination of Cognitive-Behavioral Therapy and Well-Being Therapy with Clinical Management in Cyclothymic Disorder. 61
26609700 2016
42
A Randomized Controlled Trial of Individual Family Psychoeducational Psychotherapy and Omega-3 Fatty Acids in Youth with Subsyndromal Bipolar Disorder. 61
26682997 2015
43
Cyclothymia reloaded: A reappraisal of the most misconceived affective disorder. 61
26005206 2015
44
Precursors of bipolar disorders: a systematic literature review of prospective studies. 61
26035191 2015
45
Anxiety comorbidity in bipolar spectrum disorders: the mediational role of perfectionism in prospective depressive symptoms. 61
25499686 2015
46
Negative cognitive styles synergistically predict suicidal ideation in bipolar spectrum disorders: a 3-year prospective study. 61
25660736 2015
47
Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. 61
25462111 2015
48
General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. 61
25237732 2015
49
Georg Friedrich Händel: a case of large vessel disease with complications in the eighteenth century. 61
25684296 2015
50
[Treatment of endogenous depression with venflaxine: clinical action, tolerability and personalized treatment options]. 61
25909806 2015

Variations for Cyclothymic Disorder

Expression for Cyclothymic Disorder

Search GEO for disease gene expression data for Cyclothymic Disorder.

Pathways for Cyclothymic Disorder

Pathways related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 HTR2A DRD4 DRD2
2
Show member pathways
10.16 DRD4 DRD2 COMT

GO Terms for Cyclothymic Disorder

Cellular components related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.46 HTR2A DRD2 DISC1 COMT
2 synapse GO:0045202 9.35 LAMB2 HTR2A DRD2 DISC1 CADPS2
3 glutamatergic synapse GO:0098978 8.92 HTR2A DRD4 DRD2 CADPS2

Biological processes related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.55 HTR2A DRD4
2 negative regulation of protein secretion GO:0050709 9.54 DRD4 DRD2
3 arachidonic acid secretion GO:0050482 9.52 DRD4 DRD2
4 positive regulation of neuroblast proliferation GO:0002052 9.51 DRD2 DISC1
5 temperature homeostasis GO:0001659 9.49 HTR2A DRD2
6 dopamine receptor signaling pathway GO:0007212 9.48 DRD4 DRD2
7 synaptic transmission, dopaminergic GO:0001963 9.46 DRD4 DRD2
8 negative regulation of voltage-gated calcium channel activity GO:1901386 9.43 DRD4 DRD2
9 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.4 HTR2A DRD2
10 behavioral response to ethanol GO:0048149 9.37 DRD4 DRD2
11 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.32 DRD4 DRD2
12 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.26 DRD4 DRD2
13 response to histamine GO:0034776 9.16 DRD4 DRD2
14 behavioral response to cocaine GO:0048148 9.13 HTR2A DRD4 DRD2
15 dopamine metabolic process GO:0042417 8.8 DRD4 DRD2 COMT

Molecular functions related to Cyclothymic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.33 HTR2A DRD4 DRD2
2 dopamine binding GO:0035240 9.26 DRD4 DRD2
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 8.96 DRD4 DRD2
4 dopamine neurotransmitter receptor activity GO:0004952 8.62 DRD4 DRD2

Sources for Cyclothymic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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