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MCID: CYS008
MIFTS: 56

Cystic Echinococcosis

Categories: Bone diseases, Cardiovascular diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cystic Echinococcosis

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MalaCards integrated aliases for Cystic Echinococcosis:

Name: Cystic Echinococcosis 12 58 15
Echinococcus Granulosus Infection of Lung 12 32
Echinococcus Granulosus Infection 12 71
Echinococcus Granulosus 12 15
Echinococcus Granulosus Infectious Disease of Thyroid 12
Echinococcus Granulosus Infectious Disease of Liver 12
Echinococcus Granulosus Infection of Thyroid 12
Echinococcus Granulosus Infectious Disease 12
Thyroid Echinococcus Granulosus 12
Liver Echinococcus Granulosus 12
Lung Echinococcus Granulosus 12
Unilocular Hydatid Disease 12
Unilocular Echinococcosis 12
Hydatid Disease 58
Echinococcosis 71
Hydatidosis 58
Hydatids 54

Characteristics:

Orphanet epidemiological data:

58
cystic echinococcosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Bone diseases Cardiovascular diseases Gastrointestinal diseases Respiratory diseases Neuronal diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1495
ICD9CM 34 122.4
SNOMED-CT 67 75006000
ICD10 32 B67.1 B67.4
MESH via Orphanet 44 D004443
UMLS via Orphanet 72 C0013502
Orphanet 58 ORPHA400
UMLS 71 C0013502 C0152068
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Summaries for Cystic Echinococcosis

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Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary : Cystic Echinococcosis, also known as echinococcus granulosus infection of lung, is related to clonorchiasis and sarcocystosis. An important gene associated with Cystic Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung, and related phenotypes are hepatomegaly and fatigue

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Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 920)
# Related Disease Score Top Affiliating Genes
1 clonorchiasis 30.9 MT-CO1 IL10 IGHE IFNG
2 sarcocystosis 30.8 MT-CO1 CD40LG
3 intestinal schistosomiasis 30.8 MT-CO1 IL17A IL10 CD40LG
4 toxocariasis 30.7 IL10 IGHE CD40LG
5 pleurisy 30.6 TLR4 TLR2 IFNG
6 mouth disease 30.5 TLR4 IL6 IL10 IFNG
7 keratitis, hereditary 30.4 TLR4 TLR2 IL6 IL17A
8 hypereosinophilic syndrome 30.4 IL2RA IL10 IGHE IFNG
9 coenurosis 30.4 MT-ND1 MT-CO1
10 strongyloidiasis 30.3 MT-CO1 IGHE IFNG
11 lung abscess 30.3 IL6 IFNG CD40LG
12 allergic hypersensitivity disease 30.3 IL17A IL10 IGHE IFNG
13 urticaria 30.2 IL6 IL10 IGHE CD40LG
14 radiculopathy 30.2 IL6 IL17A IL10
15 visceral leishmaniasis 30.2 TLR4 TLR2 IL10 IFNG HLA-DRB1
16 infective endocarditis 30.1 TLR2 IL6 IL17A
17 fascioliasis 30.1 MT-ND1 MT-CO1 IL10 IFNG
18 respiratory failure 30.1 TLR4 IL6 IL10 IGHE CD40LG
19 amebiasis 30.1 TLR4 TLR2 IL17A CD40LG
20 ascaris lumbricoides infection 30.1 IL6 IL10 IFNG
21 pericarditis 30.1 IL6 IFNG CD40LG
22 osteomyelitis 30.1 TLR4 TLR2 IL6 IL10 IFNG
23 neutropenia 30.0 TLR4 IL6 IL10 IFNG CD40LG
24 bronchopneumonia 30.0 TLR4 IL6 IL10 CD40LG
25 suppurative otitis media 30.0 TLR4 TLR2 CD40LG
26 aspiration pneumonia 30.0 IL6 IL17A CD40LG
27 stomatitis 30.0 TLR4 IL6 IL10 IFNG CD40LG
28 tetanus 30.0 IL6 IL2RA IL10 IFNG CD40LG
29 peritonitis 30.0 TLR4 TLR2 IL6 IL17A IL10 IFNG
30 atrophic gastritis 30.0 IL6 IL10 HLA-DRB1
31 sclerosing cholangitis 29.9 TLR4 IL6 IL10 HLA-DRB1 HLA-B CD40LG
32 eosinophilic meningitis 29.9 MT-CO1 IL10 CD40LG
33 guillain-barre syndrome 29.9 HLA-DRB1 HLA-DQB1 CD40LG
34 hypersplenism 29.9 TLR4 IL2RA IFNG
35 schistosomiasis 29.9 IL17A IL10 IGHE IFNG CD40LG
36 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.9 IL17A IL10 IFNG
37 lupus erythematosus 29.9 IL10 IFNG HLA-DRB1 HLA-DQB1 CD40LG
38 tularemia 29.8 TLR4 TLR2 IL17A CD40LG
39 gastritis 29.8 TLR4 IL6 IL17A IL10
40 cryptococcosis 29.8 IL17A IL10 IFNG
41 duodenal ulcer 29.8 TLR4 IL6 IL10 HLA-DRB1
42 sparganosis 29.8 MT-ND1 MT-CO1
43 exanthem 29.8 IL6 IL10 IFNG CD40LG
44 cysticercosis 29.8 TLR4 MT-ND1 MT-CO1 IL6 IL10 IGHE
45 neuritis 29.8 IL6 IL10 IFNG
46 invasive aspergillosis 29.8 TLR4 TLR2 IL10 IFNG
47 pyelonephritis 29.8 TLR4 IL6 IL10 IFNG
48 alveolar echinococcosis 29.7 TLR4 TLR2 TAP2 MT-ND1 MT-CO1 HLA-DRB1
49 aspergillosis 29.7 TLR4 TLR2 IL6 IL10 IFNG
50 alcoholic liver cirrhosis 29.7 TLR4 TLR2 IL6 IL10

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis
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Symptoms & Phenotypes for Cystic Echinococcosis

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Human phenotypes related to Cystic Echinococcosis:

58 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hepatomegaly 58 Occasional (29-5%)
2 fatigue 58 Frequent (79-30%)
3 weight loss 58 Frequent (79-30%)
4 urticaria 58 Very rare (<4-1%)
5 elevated hepatic transaminase 58 Occasional (29-5%)
6 cholestatic liver disease 58 Frequent (79-30%)
7 jaundice 58 Very rare (<4-1%)
8 abnormality of the eye 58 Very rare (<4-1%)
9 asthma 58 Very rare (<4-1%)
10 abnormality of the vertebral column 58 Very rare (<4-1%)
11 bone cyst 58 Very rare (<4-1%)
12 hyperbilirubinemia 58 Occasional (29-5%)
13 eosinophilia 58 Very frequent (99-80%)
14 increased antibody level in blood 58 Frequent (79-30%)
15 abnormality of the peritoneum 58 Very rare (<4-1%)
16 abnormal heart morphology 58 Very rare (<4-1%)
17 abnormality of the pancreas 58 Very rare (<4-1%)
18 abnormality of the musculature 58 Very rare (<4-1%)
19 renal cyst 58 Very rare (<4-1%)
20 abscess 58 Occasional (29-5%)
21 ovarian cyst 58 Very rare (<4-1%)
22 biliary tract obstruction 58 Occasional (29-5%)
23 anaphylactic shock 58 Occasional (29-5%)
24 localized skin lesion 58 Very rare (<4-1%)
25 abnormality of the testis size 58 Very rare (<4-1%)
26 elevated alkaline phosphatase 58 Occasional (29-5%)
27 intracranial cystic lesion 58 Very rare (<4-1%)
28 abdominal symptom 58 Occasional (29-5%)
29 epigastric pain 58 Frequent (79-30%)
30 hepatic cysts 58 Very frequent (99-80%)
31 elevated gamma-glutamyltransferase activity 58 Occasional (29-5%)
32 peritoneal abscess 58 Very rare (<4-1%)
33 abnormality of the diaphragm 58 Occasional (29-5%)
34 membranous nephropathy 58 Very rare (<4-1%)
35 abnormal pulmonary thoracic imaging finding 58 Occasional (29-5%)
36 unusual infection 58 Occasional (29-5%)
37 multiple pulmonary cysts 58 Occasional (29-5%)
38 pulmonary cyst 58 Occasional (29-5%)
39 splenic cyst 58 Very rare (<4-1%)
40 abnormal subpleural morphology 58 Very rare (<4-1%)
41 invasive parasitic infection 58 Very rare (<4-1%)

GenomeRNAi Phenotypes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

26 (show all 35)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.91 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.91 IL2RA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.91 RRAGB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.91 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.91 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.91 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.91 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.91 IL2RA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.91 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.91 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.91 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.91 RRAGB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.91 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.91 RRAGB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.91 RRAGB
16 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.91 RRAGB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.91 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.91 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.91 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.91 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.91 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.91 CES1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.91 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.91 CES1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.91 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.91 RRAGB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.91 IL10 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.91 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.91 IL10
30 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.91 CES1 IL10 IL2RA RRAGB
31 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.91 IL10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.91 RRAGB
33 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.91 IL10
34 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.91 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.91 RRAGB

MGI Mouse Phenotypes related to Cystic Echinococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 CD40LG CES1 HLA-DQB1 IFNG IL10 IL2RA
2 immune system MP:0005387 10 CD40LG HLA-DQB1 IFNG IL10 IL17A IL2RA
3 digestive/alimentary MP:0005381 9.97 HLA-DQB1 IFNG IL10 IL17A IL2RA IL6
4 endocrine/exocrine gland MP:0005379 9.97 CD40LG CES1 HLA-DQB1 IFNG IL10 IL17A
5 liver/biliary system MP:0005370 9.7 CES1 HLA-DQB1 IFNG IL10 IL6 TLR2
6 renal/urinary system MP:0005367 9.56 CD40LG CES1 HLA-DQB1 IFNG IL17A IL6
7 respiratory system MP:0005388 9.23 HLA-DQB1 IFNG IL10 IL17A IL2RA IL6
Sources

Drugs & Therapeutics for Cystic Echinococcosis

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Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Albendazole Approved, Vet_approved 54965-21-8 2082
4
Mebendazole Approved, Vet_approved 31431-39-7 4030
5 Benzimidazole Experimental, Investigational 51-17-2
6 cadexomer iodine
7 Liver Extracts
8 Anti-Infective Agents
9 Anthelmintics
10 Antiparasitic Agents
11 Antiprotozoal Agents
12 Tubulin Modulators
13 Antimitotic Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Unknown status NCT03289884
2 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
3 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
4 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
5 VATS Versus Thoracotomy for Pulmonary Hydatid Disease Completed NCT04412512
6 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
7 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
8 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Completed NCT03490435
9 Risk Factors for Major Complications After Liver Resection: Audit of a Non-Eastern/Non-Western Experience Completed NCT03967067
10 Management of Liver Hydatid Cysts: A Retrospective Analysis of 293 Cases From Southern Iran Completed NCT04363151
11 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
12 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Liver Disease Recruiting NCT03354247
13 Liver Echinococcosis; Jaundice as Initial Presentation, Short and Long Term Results of Surgical Treatment Active, not recruiting NCT04271176
14 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
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Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

40
Liver, Thyroid, Lung, Bone, Testes, Heart, Brain
Sources

Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50) (show all 1806)
# Title Authors PMID Year
1
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. 54 61
18692060 2008
2
Echinococcus granulosus in Jordan: assessment of various antigenic preparations for use in the serodiagnosis of surgically confirmed cases using enzyme immuno assays and the indirect haemagglutination test. 61 54
14972381 2004
3
Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. 54 61
15198645 2004
4
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates. 61 54
12197890 2002
5
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. 61 54
11119517 2001
6
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. 61 54
11116435 2000
7
Immunoglobulin G subclass responses in human cystic and alveolar echinococcosis. 54 61
7810806 1994
8
Genetic diversity of Echinococcus granulosus sensu stricto in Sardinia (Italy). 61
32259586 2020
9
Gene expression in human liver fibrosis associated with Echinococcus granulosus sensu lato. 61
32377911 2020
10
Control of Cystic Echinococcosis in Iran: Where Do We Stand? 61
32402838 2020
11
Cystic echinococcosis in the endemic island of Sardinia (Italy): has something changed? 61
32447517 2020
12
Genetic variability and diversity of Echinococcus granulosus sensu lato in human isolates of Pakistan based on cox1 mt-DNA sequences (366bp). 61
32302687 2020
13
In vitro efficacy study of Cinnamomum zeylanicum essential oil and cinnamaldehyde against the larval stage of Echinococcus granulosus. 61
32371061 2020
14
Comprehensive study based on mtDNA signature (nad1) providing insights on Echinococcus granulosus s.s. genotypes from Pakistan and potential role of buffalo-dog cycle. 61
32142937 2020
15
Uncommon musculoskeletal femoral hydatid cyst disturbs a female for a year: Case report. 61
32435477 2020
16
Diagnostic performance of Echinococcus granulosus protoscolices antigens in the serodiagnosis of human cystic echinococcosis. 61
32552259 2020
17
Molecular characterization of human lung and liver cystic echinococcosis isolates in Van Province, Turkey. 61
32201196 2020
18
Contribution of Anthropogenic Factors and Climate Variables to Human Cystic Echinococcosis Mortality in Chile (2001-2011). 61
32471329 2020
19
Retraction Note to: Antigen based detection of cystic echinococcosis in buffaloes using ELISA and Dot-EIA. 61
32508431 2020
20
Screening of Cystic Echinococcosis and Toxocariasis in Urmia Municipal Workers, Northwest Iran. 61
32516106 2020
21
Cytokine profiles in peripheral blood mononuclear cells from patients with cystic echinococcosis. 61
32199179 2020
22
Comment on Retrospective Study of Cystic Echinococcosis in a Recent Cohort of a Referral Center for Liver Surgery. 61
32572688 2020
23
Cystic Echinococcosis in Three Locations in the Middle Atlas, Morocco: Estimation of the Infection Rate in the Dog Reservoir. 61
32077790 2020
24
A Pilot Comparative Study Between Serological and Genetic Investigations in Relationship to Clinical Outcomes on Patients with Cystic Echinococcosis. 61
32518485 2020
25
Epidemiologic-economic models and the One Health paradigm: echinococcosis and leishmaniasis, case studies in Veneto region, Northeastern Italy. 61
32021898 2020
26
Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments. 61
32550758 2020
27
Antiparasitic effects of Zataria multiflora essential oil nano-emulsion on larval stages of Echinococcus granulosus. 61
32508418 2020
28
Executive Summary of the Consensus Statement of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Tropical Medicine and International Health (SEMTSI), the Spanish Association of Surgeons (AEC), the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), the Spanish Society of Thoracic Surgery (SECT), the Spanish Society of Vascular and Interventional Radiology (SERVEI), and the Spanish Society of Paediatric Infectious Diseases (SEIP), on the Management of Cystic Echinococcosis. 61
31866064 2020
29
A young woman from an Echinococcus-endemic area with progressive abdominal distension: a case report. 61
32507106 2020
30
The immunotherapy with hMASP-2 DNA nanolipoplexes against echinococcosis in experimentally protoscolex-infected mice. 61
32535067 2020
31
Molecular characterization of Echinococcus granulosus in livestock of Al-Madinah (Saudi Arabia). 61
32478648 2020
32
Microsatellite Investigations of Multiple Echinococcus Granulosus Sensu Stricto Cysts in Single Hosts Reveal Different Patterns of Infection Events between Livestock and Humans. 61
32516904 2020
33
Recent advances on innate immune pathways related to host-parasite cross-talk in cystic and alveolar echinococcosis. 61
32375891 2020
34
Concomitant Pulmonary Cystic Echinococcosis and Aspergillosis in a Male Child. 61
32365365 2020
35
Hospitalization for Chagas disease, dengue, filariasis, leishmaniasis, schistosomiasis, strongyloidiasis, and Taenia solium taeniasis/cysticercosis, Italy, 2011-2016. 61
32418191 2020
36
Cystic echinococcosis in the Eastern Mediterranean region: Neglected and prevailing! 61
32379760 2020
37
Genetic diversity of Echinococcus multilocularis and Echinococcus granulosus sensu lato in Kyrgyzstan: The A2 haplotype of E. multilocularis is the predominant variant infecting humans. 61
32401754 2020
38
An Atypical Presentation of Cystic Echinococcosis. 61
32426662 2020
39
Comparison of molecular and morphological characterization and haplotype analysis of cattle and sheep isolates of cystic echinococcosis. 61
32417601 2020
40
Surgically confirmed cases of cystic echinococcosis from Baluchistan Province, Pakistan for the years 2011-2018. 61
31982433 2020
41
Linking murine resistance to secondary cystic echinococcosis with antibody responses targeting Echinococcus granulosus tegumental antigens. 61
32107022 2020
42
Heterogeneity in Cystic Echinococcosis Management among Spanish Centers: Results from a National Survey. 61
32394885 2020
43
The European Register of Cystic Echinococcosis, ERCE: state-of-the-art five years after its launch. 61
32381109 2020
44
Immunological responses and potency of the EG95NC- recombinant sheep vaccine against cystic echinococcosis. 61
32464256 2020
45
First report of Echinococcus canadensis (G6/G7) by sequence analysis from the Khyber Pakhtunkhwa province of Pakistan. 61
32473988 2020
46
Myeloid-derived suppressor cells exert immunosuppressive function on the T helper 2 in mice infected with Echinococcus granulosus. 61
32446699 2020
47
Renal echinococcosis; the parasite, host immune response, diagnosis and management. 61
32525824 2020
48
A Commentary on "Major hepatectomies in liver cystic echinococcosis: A bi-centric experience. Retrospective cohort studyË® [Int. J. Surg. 2018 54 182-186]. 61
32450260 2020
49
National survey and molecular diagnosis of Echinococcus granulosus sensu lato in livestock in France, 2012. 61
32046794 2020
50
Dispersal and molecular characterisation of the Echinococcus granulosus (Batsch, 1786) complex isolated from various intermediate hosts in the Calabria region, southern Italy. 61
32458816 2020
Sources

Variations for Cystic Echinococcosis

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Expression for Cystic Echinococcosis

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Search GEO for disease gene expression data for Cystic Echinococcosis.
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Pathways for Cystic Echinococcosis

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Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.99 TLR4 TLR2 TAP2 IL6 IL2RA IL17A
2
Akt Signaling 63
Show member pathways
 13.39 TLR4 TLR2 IL6 IL2RA IL17A IL10
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.32 IL6 IL2RA IL17A IL10 IGHE IFNG
4
Herpes simplex virus 1 infection 36
12.8 TLR2 TAP2 IL6 IFNG HLA-DRB1 HLA-DQB1
5
Measles 36
Show member pathways
 12.68 TLR4 TLR2 TAP2 IL6 IL2RA IFNG
6
Immune response NFAT in immune response 22
Show member pathways
 12.65 IL2RA IL10 IGHE IFNG HLA-DRB1 HLA-DQB1
7
T cell receptor signaling pathway 36
Show member pathways
 12.58 TLR4 TLR2 IL6 IL17A IL10 IFNG
8
NF-kappaB Signaling 4
12.54 TLR2 TAP2 IL2RA IL17A IL10 IFNG
9
Antigen processing-Cross presentation 65
Show member pathways
 12.45 TLR4 TLR2 TAP2 HLA-B
10
Allograft rejection 1 36
Show member pathways
 12.4 TAP2 IL6 IL2RA IL17A IL10 IFNG
11
ICos-ICosL Pathway in T-Helper Cell 63
Show member pathways
 12.37 IL2RA HLA-DRB1 HLA-DQB1 CD40LG
12
Th17 cell differentiation 36
Show member pathways
 12.35 TLR4 TLR2 IL6 IL2RA IL17A IL10
13
Human T-cell leukemia virus 1 infection 36
12.34 IL6 IL2RA HLA-DRB1 HLA-DQB1 HLA-B
14
IL-17 Family Signaling Pathways 64
Show member pathways
 12.32 TLR2 IL6 IL17A IFNG
15
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.26 IL6 IL2RA IL17A IL10 IFNG HLA-B
16
Toxoplasmosis 36
Show member pathways
 12.22 TLR4 TLR2 IL10 IFNG HLA-DRB1 HLA-DQB1
17
Colorectal Cancer Metastasis 63
12.18 TLR4 TLR2 IL6 IFNG
18
Bacterial infections in CF airways 22
Show member pathways
 12.18 TLR4 TLR2 IL6 IFNG
19
Tuberculosis 36
12.17 TLR4 TLR2 IL6 IL10 IFNG HLA-DRB1
20
Cell adhesion molecules (CAMs) 36
12.12 HLA-DRB1 HLA-DQB1 HLA-B CD40LG
21
Phagosome 36
12.12 TLR4 TLR2 TAP2 HLA-DRB1 HLA-DQB1 HLA-B
22
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.99 IL6 IL2RA IL10 IFNG
23
Interleukin-4 and 13 signaling 65
11.98 IL6 IL17A IL10 IGHE
24
Amoebiasis 36
11.96 TLR4 TLR2 IL6 IL10 IFNG
25
IL27-mediated signaling events 1
Show member pathways
 11.94 TLR4 TLR2 IL6 IL17A IL10 IFNG
26
Hematopoietic cell lineage 36
11.9 IL6 IL2RA HLA-DRB1 HLA-DQB1
27
Th17 Differentiation 64
Show member pathways
 11.88 TLR4 TLR2 IL6 IL17A IFNG
28
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.84 TLR4 IL6 IL17A
29
Innate Lymphoid Cells Differentiation 64
11.8 IL2RA IL17A IL10 IFNG
30
Pertussis 36
11.75 TLR4 IL6 IL10
31
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.74 IL2RA IFNG CD40LG
32
Dendritic Cells Developmental Lineage Pathway 64
11.73 IL6 IL10 IFNG
33
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.65 IL6 IFNG CD40LG
34
IL4-mediated signaling events 1
11.65 IL10 IGHE CD40LG
35
Legionellosis 36
11.6 TLR4 TLR2 IL6
36
MSP-RON Signaling 63
11.52 TLR4 TLR2 IFNG
37
Th2 Differentiation 64
11.49 IL2RA IL10 IFNG
38
Malaria 36
11.43 TLR4 TLR2 IL6 IL10 IFNG CD40LG
39
African trypanosomiasis 36
11.39 IL6 IL10 IFNG
40
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.37 IL2RA IL10 IFNG
41
IL-10 Pathway 63
11.36 TLR4 IL6 IL10
42
Inflammatory Response Pathway 1
11.33 IL2RA IFNG CD40LG
43
Development and heterogeneity of the ILC family 1
11.31 IL6 IL17A IFNG
44
Cytokines and Inflammatory Response 1
11.3 IL6 IL10 IFNG HLA-DRB1
45
IL12 signaling mediated by STAT4 1
11.23 IL2RA IFNG HLA-DRB1
46
Rheumatoid arthritis 36
11.14 TLR4 TLR2 IL6 IL17A IFNG HLA-DRB1
47
Phase I biotransformations, non P450 1
10.58 CES2 CES1
Sources

GO Terms for Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 IL6 IL17A IL10 IFNG HLA-DRB1 CES2
2 cell surface GO:0009986 9.63 TLR4 TLR2 IL2RA HLA-DRB1 HLA-B CD40LG
3 phagocytic vesicle membrane GO:0030670 9.5 TLR2 TAP2 HLA-B
4 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-DRB1 HLA-DQB1 HLA-B
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-B
6 external side of plasma membrane GO:0009897 9.1 TLR4 IL2RA IL17A IGHE HLA-DRB1 CD40LG

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.04 TLR4 TLR2 TAP2 IL2RA IGHE HLA-DRB1
2 adaptive immune response GO:0002250 10.02 TAP2 IGHE IFNG HLA-DRB1 HLA-B
3 cytokine-mediated signaling pathway GO:0019221 9.96 IL6 IL2RA IL17A IL10 IGHE
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TLR4 TLR2 IL6 CD40LG
5 inflammatory response GO:0006954 9.88 TLR4 TLR2 IL6 IL2RA IL17A CD40LG
6 positive regulation of inflammatory response GO:0050729 9.83 TLR4 TLR2 IFNG
7 positive regulation of T cell proliferation GO:0042102 9.79 IL6 IL2RA CD40LG
8 positive regulation of interleukin-6 production GO:0032755 9.78 TLR4 TLR2 IL6
9 negative regulation of T cell proliferation GO:0042130 9.76 IL2RA IL10 HLA-DRB1
10 antigen processing and presentation GO:0019882 9.75 HLA-DRB1 HLA-DQB1 HLA-B
11 negative regulation of interferon-gamma production GO:0032689 9.72 TLR4 IL10 HLA-DRB1
12 positive regulation of interleukin-10 production GO:0032733 9.69 TLR4 TLR2 CD40LG
13 interferon-gamma-mediated signaling pathway GO:0060333 9.67 IFNG HLA-DRB1 HLA-DQB1 HLA-B
14 detection of bacterium GO:0016045 9.65 HLA-DRB1 HLA-B
15 I-kappaB phosphorylation GO:0007252 9.65 TLR4 TLR2
16 response to molecule of bacterial origin GO:0002237 9.65 TLR2 IL10
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 TLR4 IL6 IL17A
18 cellular response to lipoteichoic acid GO:0071223 9.64 TLR4 TLR2
19 T-helper 1 type immune response GO:0042088 9.64 TLR4 HLA-DRB1
20 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.63 IL17A IFNG
21 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.63 TLR4 IL17A
22 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.63 TLR4 IL17A IFNG
23 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.61 HLA-DRB1 HLA-DQB1
24 positive regulation of chemokine production GO:0032722 9.61 TLR4 TLR2 IL6
25 positive regulation of interleukin-23 production GO:0032747 9.6 IL17A IFNG
26 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.57 HLA-DRB1 HLA-DQB1
27 positive regulation of matrix metallopeptidase secretion GO:1904466 9.54 TLR4 TLR2
28 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.52 TLR4 TLR2
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.5 TLR4 TLR2 IFNG
30 positive regulation of interleukin-6 secretion GO:2000778 9.46 TLR4 TLR2 IL17A IFNG
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.43 TLR4 IL10 IFNG
32 immune response GO:0006955 9.4 TLR4 TLR2 IL6 IL2RA IL17A IL10
33 positive regulation of interleukin-12 production GO:0032735 9.26 TLR4 TLR2 IFNG CD40LG

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.4 HLA-DRB1 HLA-DQB1
2 sterol esterase activity GO:0004771 9.37 CES2 CES1
3 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
4 methyl indole-3-acetate esterase activity GO:0080030 9.26 CES2 CES1
5 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.16 CES2 CES1
6 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-DQB1 HLA-B
7 cytokine activity GO:0005125 9.02 IL6 IL17A IL10 IFNG CD40LG
Sources

Sources for Cystic Echinococcosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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