MCID: CYS008
MIFTS: 47

Cystic Echinococcosis

Categories: Bone diseases, Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Cystic Echinococcosis

MalaCards integrated aliases for Cystic Echinococcosis:

Name: Cystic Echinococcosis 12 59 15
Echinococcus Granulosus Infection of Lung 12 33
Echinococcus Granulosus Infection 12 72
Echinococcus Granulosus 12 15
Echinococcus Granulosus Infectious Disease of Thyroid 12
Echinococcus Granulosus Infectious Disease of Liver 12
Echinococcus Granulosus Infection of Thyroid 12
Echinococcus Granulosus Infectious Disease 12
Thyroid Echinococcus Granulosus 12
Liver Echinococcus Granulosus 12
Lung Echinococcus Granulosus 12
Unilocular Hydatid Disease 12
Unilocular Echinococcosis 12
Hydatid Disease 59
Echinococcosis 72
Hydatidosis 59
Hydatids 55

Characteristics:

Orphanet epidemiological data:

59
cystic echinococcosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1495
ICD9CM 35 122.4
SNOMED-CT 68 75006000
ICD10 33 B67.1 B67.4
MESH via Orphanet 45 D004443
UMLS via Orphanet 73 C0013502
Orphanet 59 ORPHA400
UMLS 72 C0013502 C0152068

Summaries for Cystic Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary : Cystic Echinococcosis, also known as echinococcus granulosus infection of lung, is related to alveolar echinococcosis and clonorchiasis. An important gene associated with Cystic Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response NFAT in immune response. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung.

Related Diseases for Cystic Echinococcosis

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 730)
# Related Disease Score Top Affiliating Genes
1 alveolar echinococcosis 33.3 MT-CO1 HLA-DRB1 HLA-B
2 clonorchiasis 31.3 IL10 IFNG
3 cysticercosis 30.9 MT-CO1 IL6
4 leishmaniasis 30.9 IL10 IFNG HLA-DRB1
5 fascioliasis 30.7 IL10 IFNG
6 coenurosis 30.6 MT-ND1 MT-CO1
7 tetanus 30.5 IL10 IFNG CD40LG
8 mouth disease 30.5 IL6 IL10 IFNG
9 osteomyelitis 30.2 IL6 IL10 IFNG
10 pulmonary tuberculosis 30.2 IL10 IFNG HLA-DRB1
11 taeniasis 30.2 MT-ND1 MT-CO1 IL10
12 schistosomiasis 30.2 IL10 IFNG CD40LG
13 cholangitis 30.1 IL6 HLA-DRB1 HLA-B
14 myelitis 30.1 IL6 IL17A
15 radiculopathy 30.0 IL6 IL17A IL10
16 mycobacterium tuberculosis 1 30.0 IL17A IL10 IFNG
17 spondylitis 30.0 IL6 IL17A HLA-B
18 pneumonia 29.9 IL6 IL10 CD40LG
19 filariasis 29.9 IL6 IL10 IFNG
20 toxic shock syndrome 29.9 IL6 IL10 IFNG
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.8 IL17A IL10 IFNG
22 trypanosomiasis 29.8 IL6 IL10 IFNG
23 meningitis 29.8 IL6 IL10 IFNG
24 candidiasis 29.8 IL17A IL10 IFNG
25 lung disease 29.6 IL6 IL17A IL10
26 bronchial disease 29.5 IL6 IL17A IL10
27 toxoplasmosis 29.5 IL6 IL10 IFNG CD40LG
28 bronchiolitis 29.4 IL6 IL17A IL10 IFNG
29 acquired immunodeficiency syndrome 29.2 IL6 IL10 IFNG HLA-B
30 bacterial infectious disease 29.2 IL6 IL17A IL10 IFNG
31 brucellosis 29.1 IL6 IL10 IFNG CD40LG
32 mycoplasma pneumoniae pneumonia 29.1 IL6 IL17A IL10 IFNG
33 echinococcosis 29.0 MT-ND1 MT-CO1 MT-ATP6 IL6 IL17A IL10
34 rheumatic disease 28.9 IL10 IFNG HLA-DRB1 HLA-B CD40LG
35 connective tissue disease 28.8 IL6 IL10 IFNG HLA-DRB1 CD40LG
36 parasitic helminthiasis infectious disease 28.5 MT-ND1 MT-CO1 IL10 CES2 CES1
37 asthma 28.2 IL6 IL17A IL10 IFNG HLA-DRB1 CD40LG
38 autoimmune disease 28.2 IL6 IL17A IL10 IFNG HLA-DRB1 CD40LG
39 hydatidiform mole, recurrent, 1 11.5
40 partial hydatidiform mole 11.3
41 postherpetic neuralgia 10.7 HLA-DRB1 HLA-B
42 idiopathic inflammatory myopathy 10.6 HLA-DRB1 HLA-B
43 juvenile myasthenia gravis 10.6 IL10 HLA-DRB1
44 pars planitis 10.6 HLA-DRB1 HLA-B
45 pityriasis rosea 10.6 HLA-DRB1 HLA-B
46 diarrhea 10.5
47 nontuberculous mycobacterial lung disease 10.5 HLA-DRB1 HLA-B
48 chronic beryllium disease 10.5 IFNG HLA-DRB1
49 berylliosis 10.5 IFNG HLA-DRB1
50 palladium allergic contact dermatitis 10.5 IL17A IL10

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

Drugs & Therapeutics for Cystic Echinococcosis

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Mebendazole Approved, Vet_approved 31431-39-7 4030
4
Albendazole Approved, Vet_approved 54965-21-8 2082
5 Benzimidazole Experimental, Investigational 51-17-2
6 Hematinics
7 cadexomer iodine
8 Liver Extracts
9 Antiparasitic Agents
10 Anthelmintics
11 Anti-Infective Agents
12 Tubulin Modulators
13 Antimitotic Agents
14 Antiprotozoal Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
2 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
3 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
4 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
5 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
6 Risk Factors for Major Complications After Liver Resection: Audit of a Non-Eastern/Non-Western Experience Completed NCT03967067
7 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
8 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Recruiting NCT03289884
9 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
10 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Liver Disease Recruiting NCT03354247
11 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Albendazole

Genetic Tests for Cystic Echinococcosis

Anatomical Context for Cystic Echinococcosis

MalaCards organs/tissues related to Cystic Echinococcosis:

41
Liver, Thyroid, Lung, Bone, Testes, Heart, Brain

Publications for Cystic Echinococcosis

Articles related to Cystic Echinococcosis:

(show top 50) (show all 1642)
# Title Authors PMID Year
1
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. 9 38
18692060 2008
2
Echinococcus granulosus in Jordan: assessment of various antigenic preparations for use in the serodiagnosis of surgically confirmed cases using enzyme immuno assays and the indirect haemagglutination test. 9 38
14972381 2004
3
Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. 9 38
15198645 2004
4
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates. 9 38
12197890 2002
5
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. 9 38
11119517 2001
6
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. 9 38
11116435 2000
7
Immunoglobulin G subclass responses in human cystic and alveolar echinococcosis. 9 38
7810806 1994
8
Effect of different types of macrophages on hepatic fibrosis in Echinococcus Granulosus mice. 38
31387193 2019
9
Prevalence and risk factors associated with human cystic echinococcosis in Iran. 38
31406403 2019
10
Performance of the commercially available SERION ELISA classic Echinococcus IgG test for the detection of cystic echinococcosis in clinical practice. 38
29950187 2019
11
Cystic echinococcosis and other helminth infections of wild boar in northeastern and northwestern regions of Tunisia. 38
31142388 2019
12
A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: An alternative approach. 38
31170379 2019
13
Combining proteomics and bioinformatics to explore novel tegumental antigens as vaccine candidates against Echinococcus granulosus infection. 38
31038784 2019
14
Bioinformatics analysis of EgA31 and EgG1Y162 proteins for designing a multi-epitope vaccine against Echinococcus granulosus. 38
31022474 2019
15
Evidence for camels (Camelus bactrianus) as the main intermediate host of Echinococcus granulosus sensu lato G6/G7 in Mongolia. 38
31278516 2019
16
Cystic echinococcosis in wild boars (Sus scrofa) from southern Italy: Epidemiological survey and molecular characterization. 38
31338291 2019
17
Percutaneous Treatment of Giant Cystic Echinococcosis in Liver: Catheterization Technique in Patients with CE1 and CE3a. 38
31119356 2019
18
Cystic echinococcosis in Nigeria: first insight into the genotypes of Echinococcus granulosus in animals. 38
31391113 2019
19
The efficacy of an alternative mebendazole formulation in mice infected with Echinococcus multilocularis. 38
31082364 2019
20
Genetic characterization of Echinococcus species in eastern Ethiopia. 38
31303217 2019
21
Case Report: Laparoscopic Excision of a Primary Giant Splenic Hydatid Cyst: Literature Review. 38
31407654 2019
22
Molecular identification of cystic echinococcosis in humans and pigs reveals the presence of both Echinococcus granulosus sensu stricto and Echinococcus canadensis G6/G7 in the hyperendemic focus of the Republic of Moldova. 38
31435765 2019
23
Single-Center Study: Evaluating the Diagnostic Performance and Safety of Contrast-Enhanced Ultrasound (CEUS) in Pregnant Women to Assess Hepatic Lesions. 38
31362328 2019
24
[Diagnostics and management of intra-abdominal Echinococcus manifestation]. 38
31312861 2019
25
Genetic survey of cystic echinococcosis in farm animals in Oman. 38
31338730 2019
26
Complications Associated with Initial Clinical Presentation of Cystic Echinococcosis: A 20-year Cohort Analysis. 38
31359859 2019
27
Letter to editor about the article: Should Pediatricians be aware of cystic Echinococcosis? A literature review. 38
31348123 2019
28
Response - Letter to Editor About the Article: Should Pediatricians be Aware of Cystic Echinococcosis? A Literature Review. 38
31348122 2019
29
Epidemiological factors associated with human cystic echinococcosis: a semi-structured questionnaire from a large population-based ultrasound cross-sectional study in eastern Europe and Turkey. 38
31358039 2019
30
Comparison of the Utility of Recombinant B8/2 Subunit of the Antigen B, Native Antigen, and a Commercial ELISA Kit in the Diagnosis of Human Cystic Echinococcosis 38
30368233 2019
31
Echinococcus Granulosus in Childhood: A Retrospective Study of 187 Cases and Newer Data. 38
31081377 2019
32
Echinococcus Granulosus in the Endangered Patagonian Huemul (Hippocamelus bisulcus). 38
30789781 2019
33
First detection of zoonotic tapeworm Echinococcus granulosus sensu lato genotype G7 in continental Italy. 38
31134335 2019
34
Hydatid cyst of the thyroid gland with tracheal fistula: A case report and review of the literature. 38
31281444 2019
35
Genotyping and phylogenetic analysis of unusually located hydatid cysts isolated from humans in north-east Iran. 38
31331413 2019
36
Identification of antigen B (AgB) Gene polymorphism in cattle and sheep isolates of Echinococcus granulosus and investigation of effects on serological diagnosis. 38
31356785 2019
37
Cystic echinococcosis in unaccompanied minor refugees from Afghanistan and the Middle East to Germany, July 2016 through June 2017. 38
30739267 2019
38
Not just minor resections: robotic approach for cystic echinococcosis of the liver. 38
31236898 2019
39
The pattern of cystic echinococcosis in children in an endemic area in Morocco. 38
31263325 2019
40
Standardized endocystectomy technique for surgical treatment of uncomplicated hepatic cystic echinococcosis. 38
31226109 2019
41
Retrospective Study of Cystic Echinococcosis in a Recent Cohort of a Referral Center for Liver Surgery. 38
30242646 2019
42
Survey of echinococcoses in southeastern Qinghai Province, China, and serodiagnostic insights of recombinant Echinococcus granulosus antigen B isoforms. 38
31242932 2019
43
Risk Factors for Human Cystic Echinococcosis in Latvia. 38
30801230 2019
44
Diagnosis and treatment of a case of hepatic mixed echinococcosis infection combined with distant organ metastasis. 38
31156003 2019
45
In-vitro evaluation of Nigella sativa and Punica granatum effect on protoscolices of hydatid cysts. 38
31215605 2019
46
Scolicidal Effects of Chitosan-Curcumin Nanoparticles on the Hydatid Cyst Protoscolices. 38
31087261 2019
47
Cloning, expression, characterization, and immunological properties of citrate synthase from Echinococcus granulosus. 38
31049696 2019
48
Occurrence of Liver Hydatid Cysts in a Donkey and Molecular Characterization of Echinococcus equinus. 38
31192761 2019
49
Analysis of nad2 and nad5 enables reliable identification of genotypes G6 and G7 within the species complex Echinococcus granulosus sensu lato. 38
31247339 2019
50
Corrigendum to: Epidemiology, diagnosis, treatment and follow-up of cystic echinococcosis in asymptomatic carriers. 38
31087080 2019

Variations for Cystic Echinococcosis

Expression for Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for Cystic Echinococcosis

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 IL6 IL17A IL10 IFNG HLA-DRB1 HLA-B
2
Show member pathways
12.49 IL10 IFNG HLA-DRB1 CD40LG
3
Show member pathways
12.44 IL6 IL17A IL10 IFNG
4 12.41 IL17A IL10 IFNG CD40LG
5
Show member pathways
12.39 IL6 IL17A IL10 IFNG HLA-DRB1
6
Show member pathways
12.26 IL6 IL17A IL10 IFNG CD40LG
7
Show member pathways
12.24 IL6 IL17A IL10 IFNG HLA-DRB1 HLA-B
8
Show member pathways
12.12 IL10 IFNG HLA-DRB1 CD40LG
9 12.08 IL6 IL10 IFNG HLA-DRB1
10
Show member pathways
12.01 IL6 IL17A IL10 IFNG HLA-B
11 11.98 HLA-DRB1 HLA-B CD40LG
12
Show member pathways
11.93 IL6 IL17A IL10 IFNG
13 11.86 IL6 IL10 IFNG
14
Show member pathways
11.85 IL6 IL17A IL10 IFNG
15 11.84 IL6 IL17A IL10
16 11.78 IL6 IL10 IFNG
17 11.75 IL6 IL10 IFNG
18 11.66 IL17A IL10 IFNG
19 11.64 IL6 IL17A IFNG HLA-DRB1
20 11.61 IL6 IL10 IFNG
21
Show member pathways
11.53 IL6 IFNG CD40LG
22 11.41 IL6 IL17A IL10 IFNG
23 11.25 IL6 IL10 IFNG
24 11.16 IL6 IL17A IFNG
25 11.15 IL6 IL10 IFNG CD40LG
26 11.09 IFNG HLA-DRB1
27 11.07 IL6 IL17A IL10 CD40LG
28 11.06 IL10 IFNG
29 10.85 IL6 IL17A IL10 CD40LG
30 10.48 CES2 CES1
31 10.39 IL6 IL10 IFNG HLA-DRB1

GO Terms for Cystic Echinococcosis

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 IL6 IL17A IL10 IFNG CES2 CES1
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DRB1 HLA-B

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.58 MT-CO1 MT-ATP6 IL10
2 inflammatory response GO:0006954 9.56 IL6 IL17A IL10 CD40LG
3 negative regulation of interferon-gamma production GO:0032689 9.43 IL10 HLA-DRB1
4 positive regulation of interleukin-12 production GO:0032735 9.37 IFNG CD40LG
5 interferon-gamma-mediated signaling pathway GO:0060333 9.33 IFNG HLA-DRB1 HLA-B
6 positive regulation of osteoclast differentiation GO:0045672 9.32 IL17A IFNG
7 immune response GO:0006955 9.17 IL6 IL17A IL10 IFNG HLA-DRB1 HLA-B
8 positive regulation of interleukin-23 production GO:0032747 8.96 IL17A IFNG

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL6 IL17A IL10 IFNG CD40LG
2 methylumbelliferyl-acetate deacetylase activity GO:0047374 8.96 CES2 CES1

Sources for Cystic Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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