MCID: CYS008
MIFTS: 53

Cystic Echinococcosis

Categories: Bone diseases, Cardiovascular diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Cystic Echinococcosis

MalaCards integrated aliases for Cystic Echinococcosis:

Name: Cystic Echinococcosis 11 58 28 14
Echinococcus Granulosus Infection of Lung 11 31
Echinococcus Granulosus Infection 11 71
Echinococcus Granulosus 11 75
Echinococcus Granulosus Infectious Disease of Thyroid 11
Echinococcus Granulosus Infectious Disease of Liver 11
Echinococcus Granulosus Infection of Thyroid 11
Echinococcus Granulosus Infectious Disease 11
Thyroid Echinococcus Granulosus 11
Liver Echinococcus Granulosus 11
Lung Echinococcus Granulosus 11
Unilocular Hydatid Disease 11
Unilocular Echinococcosis 11
Hydatid Disease 58
Echinococcosis 71
Hydatidosis 58

Characteristics:


Prevelance:

1-9/100000 (Europe) 58

Age Of Onset:

Adult 58

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Cystic Echinococcosis

Disease Ontology: 11 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection of lung, is related to echinococcosis and alveolar echinococcosis. An important gene associated with Cystic Echinococcosis is MIR26B (MicroRNA 26b), and among its related pathways/superpathways are Innate Lymphoid Cells Differentiation and Th2 Differentiation. The drugs Metronidazole and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and bone, and related phenotypes are eosinophilia and hepatic cysts

Orphanet: 58 Hydatidosis or cyst hydatic disease is a cosmopolitan larval cestodosis caused principally by the Echinococcus granulosus tapeworm, the adult form of which parasitises the intestine of dogs. Hydatidosis generally affects large domestic herbivores; humans are dead-end hosts, infected through contact with herding dogs or through ingestion of food contaminated with canine excrement.

Wikipedia: 75 Echinococcus granulosus, also called the hydatid worm, hyper tape-worm or dog tapeworm, is a... more...

Related Diseases for Cystic Echinococcosis

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 697)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 32.9 MT-CO1 MT-ATP6 IL10
2 alveolar echinococcosis 31.7 RRAGB MT-ND1 MT-CO1 IL4 IL10 CES2
3 fascioliasis 30.7 MT-ND1 MT-CO1 IL4 IL10
4 polycystic echinococcosis 30.5 MT-ND1 MT-CO1 CES1
5 ancylostomiasis 30.5 MT-ND5 MT-ND1 MT-CO1
6 mouth disease 30.3 MIR30A MIR21 IL10 H2AC18
7 enterobiasis 30.2 MT-CO1 IL4
8 toxoplasmosis 30.2 MIR21 IL4 IL10
9 coenurosis 30.2 MT-ND5 MT-ND1 MT-CO1
10 salmonellosis 30.1 IL4 IL10 CD4
11 cysticercosis 30.1 MT-ND5 MT-ND1 MT-CO1 IL4 IL10 CES2
12 dicrocoeliasis 30.1 MT-ND5 MT-ND1 MT-ATP6
13 stomatitis 30.1 IL4 IL10 CD4
14 spinal cord disease 30.0 IL10 H2AC18 CD4
15 ascaris lumbricoides infection 30.0 MT-ND1 IL4 IL10 CD4
16 intestinal schistosomiasis 30.0 MT-CO1 IL4 IL10 CD4
17 visceral leishmaniasis 29.9 IL4 IL10 H2AC18 CD4
18 sparganosis 29.9 MT-ND5 MT-ND1 MT-CO1 MT-ATP6
19 giardiasis 29.9 IL10 H2AC18 CD4
20 actinomycosis 29.9 IL10 CD4
21 trichinosis 29.9 IL4 IL10 CD4
22 t cell deficiency 29.9 IL4 IL10 CD4
23 amebiasis 29.9 IL4 IL10 CD4
24 splenic disease 29.8 IL4 IL10 H2AC18 CD4
25 allergic disease 29.8 MIR21 IL4 IL10 H2AC18 CD4
26 strongyloidiasis 29.7 MT-CO1 IL4 IL10 CD4
27 filarial elephantiasis 29.7 MT-CO1 IL4 IL10 CD4
28 filariasis 29.7 MT-CO1 IL4 IL10 CD4
29 urinary tract infection 29.7 IL10 H2AC18 CD4
30 cryptococcosis 29.7 IL4 IL10 CD4
31 trypanosomiasis 29.7 IL4 IL10 H2AC18 CD4
32 pleural disease 29.7 MIR21 H2AC18 CD4
33 autoimmune lymphoproliferative syndrome 29.6 MT-CO1 MIR21 IL10 CD4
34 parasitic helminthiasis infectious disease 29.6 MT-ND1 MT-CO1 MIR21 IL4 IL10 H2AC18
35 lymphangioma 29.6 IL10 H2AC18 CD4
36 viral infectious disease 29.5 MIR21 IL4 IL10 H2AC18 CD4
37 respiratory failure 29.5 MIR21 IL4 IL10 H2AC18 CD4
38 chagas disease 29.5 IL4 IL10 CD4
39 taeniasis 29.3 MT-ND5 MT-ND1 MT-CO1 IL4 IL10 CES2
40 immune deficiency disease 29.3 MIR30A MIR21 IL4 IL10 H2AC18 CD4
41 lipoprotein quantitative trait locus 29.3 MIR30A MIR21 IL4 IL10 H2AC18 CD4
42 systemic lupus erythematosus 28.9 MT-ATP6 MIR30A MIR21 LSM2 IL4 IL10
43 peripheral nervous system disease 28.3 MT-ND1 MT-ATP6 MIR542 MIR30A MIR21 IL4
44 connective tissue disease 28.3 MIR542 MIR30A MIR26B MIR21 LSM2 IL4
45 toe syndactyly, telecanthus, and anogenital and renal malformations 10.5
46 diarrhea 10.4
47 hypolipoproteinemia 10.4
48 mesocestoidiasis 10.4 MT-ND1 MT-CO1
49 large intestine adenoma 10.4 CES2 CES1
50 echinostomiasis 10.4 MT-ND1 MT-CO1

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

Human phenotypes related to Cystic Echinococcosis:

58 30 (show all 44)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 eosinophilia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001880
2 hepatic cysts 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001407
3 fatigue 58 30 Frequent (33%) Frequent (79-30%)
HP:0012378
4 cholestatic liver disease 58 30 Frequent (33%) Frequent (79-30%)
HP:0002611
5 weight loss 58 30 Frequent (33%) Frequent (79-30%)
HP:0001824
6 epigastric pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0410019
7 increased circulating antibody level 30 Frequent (33%) HP:0010702
8 hepatomegaly 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002240
9 elevated hepatic transaminase 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002910
10 hyperbilirubinemia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002904
11 biliary tract obstruction 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005230
12 abdominal symptom 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0011458
13 anaphylactic shock 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100845
14 abnormality of the diaphragm 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000775
15 abnormal pulmonary thoracic imaging finding 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0031983
16 multiple pulmonary cysts 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005948
17 elevated circulating alkaline phosphatase concentration 30 Occasional (7.5%) HP:0003155
18 elevated gamma-glutamyltransferase level 30 Occasional (7.5%) HP:0030948
19 asthma 58 30 Very rare (1%) Very rare (<4-1%)
HP:0002099
20 jaundice 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000952
21 abnormality of the eye 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000478
22 abnormality of the vertebral column 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000925
23 urticaria 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001025
24 bone cyst 58 30 Very rare (1%) Very rare (<4-1%)
HP:0012062
25 abnormal heart morphology 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001627
26 abnormality of the pancreas 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001732
27 renal cyst 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000107
28 localized skin lesion 58 30 Very rare (1%) Very rare (<4-1%)
HP:0011355
29 abnormality of the testis size 58 30 Very rare (1%) Very rare (<4-1%)
HP:0045058
30 ovarian cyst 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000138
31 intracranial cystic lesion 58 30 Very rare (1%) Very rare (<4-1%)
HP:0010576
32 peritoneal abscess 58 30 Very rare (1%) Very rare (<4-1%)
HP:0100592
33 membranous nephropathy 58 30 Very rare (1%) Very rare (<4-1%)
HP:0012578
34 splenic cyst 58 30 Very rare (1%) Very rare (<4-1%)
HP:0030423
35 abnormal subpleural morphology 58 30 Very rare (1%) Very rare (<4-1%)
HP:0031630
36 invasive parasitic infection 58 30 Very rare (1%) Very rare (<4-1%)
HP:0031700
37 increased antibody level in blood 58 Frequent (79-30%)
38 abnormality of the peritoneum 58 Very rare (<4-1%)
39 abnormality of the musculature 58 Very rare (<4-1%)
40 abscess 58 Occasional (29-5%)
41 elevated alkaline phosphatase 58 Occasional (29-5%)
42 elevated gamma-glutamyltransferase activity 58 Occasional (29-5%)
43 pulmonary cyst 58 Occasional (29-5%)
44 unusual infection 58 Occasional (29-5%)

Drugs & Therapeutics for Cystic Echinococcosis

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1, 69198-10-3 4173
2
Albendazole Approved, Vet_approved 54965-21-8 2082
3
Mebendazole Approved, Vet_approved 31431-39-7 4030
4
Benzimidazole Experimental, Investigational 51-17-2 5798
5 Liver Extracts
6 Antiparasitic Agents
7 Anti-Infective Agents
8 Antimitotic Agents
9 Antiprotozoal Agents
10 Anthelmintics
11 Tubulin Modulators
12 Pharmaceutical Solutions
13 Anesthetics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Unknown status NCT03289884
2 Liver Echinococcosis; Jaundice as Initial Presentation, Short and Long Term Results of Surgical Treatment Unknown status NCT04271176
3 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
4 Surgical Treatment of Hepatic Hydatidosis in Elderly Patients Completed NCT05113550
5 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
6 VATS Versus Thoracotomy for Pulmonary Hydatid Disease Completed NCT04412512
7 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
8 Outcome After Surgical Treatment of Liver Hydatid Cyst Completed NCT05420155
9 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
10 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
11 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
12 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Completed NCT02876146 Benzimidazole
13 Management of Liver Hydatid Cysts: A Retrospective Analysis of 293 Cases From Southern Iran Completed NCT04363151
14 Splenic Preserving Surgery in Hydatid Spleen Completed NCT04890899
15 Intracranial Hydatid Cyst: Series of 8 Cases Completed NCT04454268
16 Occult Cysto-biliary Communication and Cyst Fluid Analysis Predicts Post-operative Biliary Fistula and Late Recurrence After Laparoscopic Partial Cystectomy With Omentoplasty in Solitary Primary Adult Liver Hydatid Cyst Disease - A Prospective Multicenter Study. Completed NCT05116735
17 Radical Versus Conservative Surgical Treatment of Liver Hydatid Cysts: A Propensity Score Matching Analysis Completed NCT04988958
18 Systematic Review of Hypernatremia Following Hydatid Cyst Treatment Recruiting NCT05090020

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole

Genetic Tests for Cystic Echinococcosis

Genetic tests related to Cystic Echinococcosis:

# Genetic test Affiliating Genes
1 Cystic Echinococcosis 28

Anatomical Context for Cystic Echinococcosis

Organs/tissues related to Cystic Echinococcosis:

MalaCards : Liver, Lung, Bone, Thyroid, Small Intestine, Heart, Brain

Publications for Cystic Echinococcosis

Articles related to Cystic Echinococcosis:

(show top 50) (show all 10628)
# Title Authors PMID Year
1
Mediastinal and pericardial hydatidosis: A case report with review of the literature. 62
36465165 2023
2
Alterations in Gut Microbiota Profiles of Mice Infected with Echinococcus granulosus sensu lato Microbiota Profiles of Mice Infected with E. granulosus s.l. 62
36048399 2022
3
In vitro efficacy of albendazole-loaded β-cyclodextrin against protoscoleces of Echinococcus granulosus sensu stricto. 62
36384195 2022
4
Morbidity and Mortality Risk Factors for Lung Hydatidosis Surgery: Over 30 Years' Experience Review. 62
34808112 2022
5
Anti-echinococcal effects of sumac, Rhus coriaria, in a murine model of cystic echinococcosis: Parasitological and molecular evaluation. 62
36244447 2022
6
A Comparative Evaluation of Four Different Immunoassays in the Diagnosis of Cystic Echinococcosis Using a Crude and Purified Hydatid Cyst Fluid Antigen. 62
36125652 2022
7
'Fight the parasite': raising awareness of cystic echinococcosis in primary school children in endemic countries. 62
36461072 2022
8
Meta-analysis of the prevalence of bovine cystic echinococcosis in China during decade. 62
36150257 2022
9
Deciphering the role of miR-71 and let-7 in the fertility of cystic echinococcosis cysts: a preliminary assessment. 62
36266590 2022
10
Isolated peritoneal involvement as a primary manifestation of cystic echinococcosis. 62
36435190 2022
11
A rare case of hydatid cyst of the neck with concurrent pulmonary hydatid disease. 62
36457772 2022
12
Cerebral hydatid cyst in children: A case series of 21 patients and review of literature. 62
35907445 2022
13
Enhancing respiratory disease diagnosis by bronchoalveolar lavage in Kashmir: an audit of findings. 62
35948407 2022
14
A CT-based radiomics nomogram for the differentiation of pulmonary cystic echinococcosis from pulmonary abscess. 62
36181541 2022
15
Efficacy of Mesenchymal Stem Cells Therapy in Parasitic Infections: Are Anti-parasitic Drugs Combined with MSCs More Effective? 62
36280646 2022
16
Anti-helminthic effects and cellular mechanisms of Astragalus ecbatanus extract against Echinococcus granulosus protoscoleces. 62
36457771 2022
17
Multiple intracranial hydatid cysts in posterior fossa in an adult-A case report. 62
36204412 2022
18
[Patient with pulmonary cysts and diagnosis of co-infection with tuberculosis and hydatidosis. Pediatric cases report]. 62
36374065 2022
19
Is There Any Role of Pulmonary Endarterectomy in Pulmonary Arterial Hydatidosis? 62
34843694 2022
20
Histopathological and immunological study of rats liver hydatid cysts isolated from human, sheep, goat and cows. 62
36457784 2022
21
Aortic aneurysm lesions in Echinococcus infection. A review of cases in literature. 62
36257589 2022
22
Spontaneous cutaneous fistula secondary to hepatic hydatidosis. 62
36435381 2022
23
Peritoneal hydatidosis: An exceptional case report. 62
36389191 2022
24
Hydatid Disease of the Liver Presenting as Spontaneous Cutaneous Fistula: A case report. 62
36407698 2022
25
The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children. 62
36443650 2022
26
Breast hydatid cyst presented as a fluctuant painless lump mimicking galactocele: A case report. 62
36356796 2022
27
Genotyping and Identification of Antigen B Gene Polymorphism of Echinococcus granulosus in Edirne, Thrace, and the First Report of Genotype G2 (Tasmanian Sheep Strain) in Turkey 62
36194122 2022
28
Experimental treatment of cystic echinococcosis: Combination therapy with carvacrol and thymol versus albendazole. 62
36435216 2022
29
Surgical Management of Cardiac Cystic Echinococcosis in a Pediatric Patient: A Case Report. 62
36420984 2022
30
Comparative analysis of anti-relapse treatment regimens in 110 patients with hepatic and pulmonary hydatid echinococcosis. 62
36459040 2022
31
Comment on "Usefulness of the FDG PET/CT in the management of cystic echinococcosis: A pilot study". 62
36462531 2022
32
The occurrence of cystic echinococcosis in slaughtered livestock in Jahrom, south of Iran. 62
36118047 2022
33
Serum Level of egr-miR-2a-3p as a Potential Diagnostic Biomarker for Cystic Echinococcosis. 62
36434379 2022
34
Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project. 62
36427513 2022
35
In Silico Evaluation of the Haplotype Diversity, Phylogenetic Variation and Population Structure of Human E. granulosus sensu stricto (G1 Genotype) Sequences. 62
36422598 2022
36
Multiple recurrent cystic hydatid disease of abdominal cavity. 62
35643904 2022
37
Hydatid disease of the brain and spine. 62
36443475 2022
38
Hydatid liver disease with portal vein invasion, cavernous transformation and portal biliopathy. 62
35485257 2022
39
Primary hydatid cyst of the kidney revealed by hydatiduria: A case report. 62
36212223 2022
40
Atypical manifestation of a fistula between a hydatid cyst of a liver and a gallbladder: A case report. 62
35965928 2022
41
Primary mesenteric hydatid cyst; a rare manifestation of hydatid disease through a case report and literature review. 62
36115120 2022
42
Biliary cystadenoma: Case report with MRI findings and surgical confirmation. 62
35991384 2022
43
François-Amilcar Aran (1817-1861) and the recognition of spinal muscular atrophy. 62
35513931 2022
44
Protection against cystic echinococcosis in sheep using an Escherichia coli-expressed recombinant antigen (EG95) as a bacterin. 62
36226566 2022
45
Africa-wide meta-analysis on the prevalence and distribution of human cystic echinococcosis and canine Echinococcus granulosus infections. 62
36199100 2022
46
Treatment of protoscoleces with gamma radiation: Potential immunoprotective effect against experimental murine echinococcosis. 62
36054717 2022
47
Analysis of vaccination strategy against cystic echinococcosis developed in the Province of Río Negro, Argentina: 12 years of work. 62
36054969 2022
48
Prediction of the potential suitable habitat of Echinococcus granulosus, the pathogen of echinococcosis, in the Tibetan Plateau under future climate scenarios. 62
36269480 2022
49
Cardiac Echinococcosis With Hepatic Involvement in a Child: A Case Report. 62
36407185 2022
50
Conjugated silver nanoparticles as a diagnostic tool for circulating hydatid antigens. 62
36198106 2022

Variations for Cystic Echinococcosis

Expression for Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for Cystic Echinococcosis

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 IL4 IL10 CD4
2 10.79 IL4 IL10 CD4
3 10.5 IL4 CD4
4
Show member pathways
10.3 CES2 CES1
5 10.26 IL4 IL10 CD4

GO Terms for Cystic Echinococcosis

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respirasome GO:0070469 8.8 MT-ND5 MT-ND1 MT-CO1

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type 2 immune response GO:0042092 9.46 IL4 IL10
2 regulation of isotype switching GO:0045191 9.26 IL4 IL10
3 electron transport coupled proton transport GO:0015990 8.92 MT-ND5 MT-CO1

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.26 CES2 CES1
2 methyl indole-3-acetate esterase activity GO:0080030 8.62 CES2 CES1

Sources for Cystic Echinococcosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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