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MCID: CYS008
MIFTS: 51

Cystic Echinococcosis

Categories: Bone diseases, Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cystic Echinococcosis

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MalaCards integrated aliases for Cystic Echinococcosis:

Name: Cystic Echinococcosis 12 58 15
Echinococcus Granulosus Infection of Lung 12 32
Echinococcus Granulosus Infection 12 71
Echinococcus Granulosus 12 15
Echinococcus Granulosus Infectious Disease of Thyroid 12
Echinococcus Granulosus Infectious Disease of Liver 12
Echinococcus Granulosus Infection of Thyroid 12
Echinococcus Granulosus Infectious Disease 12
Thyroid Echinococcus Granulosus 12
Liver Echinococcus Granulosus 12
Lung Echinococcus Granulosus 12
Unilocular Hydatid Disease 12
Unilocular Echinococcosis 12
Hydatid Disease 58
Echinococcosis 71
Hydatidosis 58
Hydatids 54

Characteristics:

Orphanet epidemiological data:

58
cystic echinococcosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Bone diseases Cardiovascular diseases Endocrine diseases Gastrointestinal diseases Respiratory diseases Neuronal diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1495
ICD9CM 34 122.4
SNOMED-CT 67 75006000
ICD10 32 B67.1 B67.4
MESH via Orphanet 44 D004443
UMLS via Orphanet 72 C0013502
Orphanet 58 ORPHA400
UMLS 71 C0013502 C0152068
Sources

Summaries for Cystic Echinococcosis

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Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary : Cystic Echinococcosis, also known as echinococcus granulosus infection of lung, is related to clonorchiasis and angioedema. An important gene associated with Cystic Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung, and related phenotypes are digestive/alimentary and liver/biliary system

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Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 893)
# Related Disease Score Top Affiliating Genes
1 clonorchiasis 31.1 IL10 IGHE IFNG
2 angioedema 30.6 IL6 IGHE CD40LG
3 alveolar echinococcosis 30.6 TLR4 TLR2 MT-CO1 HLA-DRB1 HLA-DQB1 HLA-B
4 mouth disease 30.5 TLR4 IL6 IL10 IFNG
5 diarrhea 30.5 TLR4 IL6 IL10 IFNG CD40LG
6 coenurosis 30.4 MT-ND1 MT-CO1
7 pleurisy 30.4 TLR4 TLR2 IFNG
8 tetanus 30.3 IL6 IL10 IFNG CD40LG
9 lung abscess 30.3 IL6 IFNG CD40LG
10 strongyloidiasis 30.3 IGHE IFNG CD40LG
11 urticaria 30.2 IL6 IGHE CD40LG
12 radiculopathy 30.2 IL6 IL17A IL10
13 pericarditis 30.1 IL6 IFNG CD40LG
14 fascioliasis 30.0 MT-ND1 MT-CO1 IL10 IFNG
15 syphilis 30.0 IL17A IGHE HLA-DRB1 CD40LG
16 peritonitis 30.0 TLR4 TLR2 IL6 IL10 IFNG
17 sparganosis 30.0 MT-ND1 MT-CO1
18 bronchopneumonia 30.0 TLR4 IL6 IL10 CD40LG
19 visceral leishmaniasis 30.0 TLR4 TLR2 IL10 IFNG HLA-DRB1
20 eosinophilic meningitis 29.9 IL10 IGHE CD40LG
21 exanthem 29.9 IL6 IL10 CD40LG
22 aspiration pneumonia 29.9 IL6 IL17A CD40LG
23 atrophic gastritis 29.9 IL6 IL10 HLA-DRB1
24 cellulitis 29.9 IL6 IL10 CD40LG
25 guillain-barre syndrome 29.9 HLA-DRB1 HLA-DQB1 CD40LG
26 infective endocarditis 29.9 TLR2 IL6 IL17A
27 keratitis, hereditary 29.9 TLR4 TLR2 IL6 IL17A IL10
28 sclerosing cholangitis 29.8 TLR4 IL6 IL10 HLA-DRB1 HLA-B CD40LG
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.8 IL17A IL10 IFNG
30 amebiasis 29.8 TLR4 TLR2 IL17A CD40LG
31 lupus erythematosus 29.8 IL10 IFNG HLA-DRB1 HLA-DQB1 CD40LG
32 cryptococcosis 29.8 IL17A IL10 IFNG
33 schistosomiasis 29.8 IL17A IL10 IGHE IFNG CD40LG
34 lymphadenitis 29.8 TLR4 IL10 IFNG
35 osteomyelitis 29.8 TLR4 TLR2 IL6 IL10 IFNG
36 gastritis 29.8 TLR4 IL6 IL17A IL10
37 autoimmune hepatitis 29.8 IL10 HLA-DRB1 HLA-DQB1 CD40LG
38 suppurative otitis media 29.8 TLR4 TLR2 CD40LG
39 duodenal ulcer 29.8 TLR4 IL6 IL10 HLA-DRB1
40 acute chest syndrome 29.7 HLA-DRB1 HLA-DQB1 CD40LG
41 pyelonephritis 29.7 TLR4 IL6 IL10 IFNG
42 cysticercosis 29.7 TLR4 MT-ND1 MT-CO1 IL6 IL10 IGHE
43 allergic bronchopulmonary aspergillosis 29.7 IL10 IGHE IFNG HLA-DRB1
44 spondyloarthropathy 1 29.6 TLR4 IL17A HLA-B CD40LG
45 neuritis 29.6 IL6 IL10 IFNG
46 appendicitis 29.6 TLR4 IL6 IL17A IL10 IFNG
47 ileus 29.6 IL6 IL17A IL10 IFNG
48 vasculitis 29.5 IL6 IL17A HLA-B CD40LG
49 invasive aspergillosis 29.5 TLR4 TLR2 IL10 IFNG
50 myeloma, multiple 29.5 TLR4 IL6 IL17A IL10 IFNG CD40LG

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis
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Symptoms & Phenotypes for Cystic Echinococcosis

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MGI Mouse Phenotypes related to Cystic Echinococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 HLA-DQB1 IFNG IL10 IL17A IL6 TLR2
2 liver/biliary system MP:0005370 9.7 CES1 HLA-DQB1 IFNG IL10 IL6 TLR2
3 renal/urinary system MP:0005367 9.56 CD40LG CES1 HLA-DQB1 IFNG IL17A IL6
4 respiratory system MP:0005388 9.17 HLA-DQB1 IFNG IL10 IL17A IL6 TLR2
Sources

Drugs & Therapeutics for Cystic Echinococcosis

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Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Albendazole Approved, Vet_approved 54965-21-8 2082
4
Mebendazole Approved, Vet_approved 31431-39-7 4030
5 Benzimidazole Experimental, Investigational 51-17-2
6 Hematinics
7 cadexomer iodine
8 Liver Extracts
9 Anti-Infective Agents
10 Anthelmintics
11 Antiparasitic Agents
12 Antimitotic Agents
13 Antiprotozoal Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
2 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
3 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
4 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
5 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
6 Risk Factors for Major Complications After Liver Resection: Audit of a Non-Eastern/Non-Western Experience Completed NCT03967067
7 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
8 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Recruiting NCT03289884
9 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
10 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Liver Disease Recruiting NCT03354247
11 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
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Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

40
Liver, Thyroid, Lung, Bone, Testes, Heart, Brain
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Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50) (show all 1696)
# Title Authors PMID Year
1
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. 61 54
18692060 2008
2
Echinococcus granulosus in Jordan: assessment of various antigenic preparations for use in the serodiagnosis of surgically confirmed cases using enzyme immuno assays and the indirect haemagglutination test. 54 61
14972381 2004
3
Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. 61 54
15198645 2004
4
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates. 61 54
12197890 2002
5
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. 61 54
11119517 2001
6
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. 61 54
11116435 2000
7
Immunoglobulin G subclass responses in human cystic and alveolar echinococcosis. 54 61
7810806 1994
8
Microwave ablation combining surgery for the treatment of multiorgan cystic echinococcosis: A case report. 61
31026594 2020
9
Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens With Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis. 61
31567204 2020
10
A hyperendemic focus of porcine cystic echinococcosis in the Banke District of Nepal. 61
31574252 2020
11
The combination of Cytokines and albendazole therapy for prophylaxis and treatment of experimental/hydatid cyst. 61
31586448 2020
12
Disease burden of echinococcosis in Tibetan communities-a significant public health issue in an underdeveloped region of western China. 61
31811863 2019
13
Control of cystic echinococcosis: Background and prospects. 61
31529690 2019
14
Incidence Rates of Surgically Managed Cystic Echinococcosis in Kazakhstan, 2007-2016. 61
31802731 2019
15
Cystic echinococcosis: a 10-year experience from a middle-income country. 61
31805832 2019
16
The current prevalence and diversity of cystic echinococcosis in slaughtered animals in Egypt. 61
31749543 2019
17
Economic Effect of Confiscation of Cattle Viscera Infected with Cystic Echinococcosis, Huancayo Province, Peru. 61
31742527 2019
18
Not just minor resections: robotic approach for cystic echinococcosis of the liver. 61
31236898 2019
19
Retrospective Study of Cystic Echinococcosis (CE) Based on Hospital Record from Five Major Metropolitan Cities of Pakistan. 61
31463885 2019
20
Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid from patients: isolation, characterization and evaluation of immunomodulatory functions on T cells. 61
31734339 2019
21
Genotyping of human Echinococcus granulosus cyst in Morocco. 61
31749525 2019
22
Role of stellate cells in hepatic echinococcosis in cattle. 61
31749527 2019
23
Detection of Echinococcus granulosus sensu lato infection by using extracts derived from a protoscoleces G1 cell line. 61
31557338 2019
24
Diagnostic Performances of Commercial ELISA, Indirect Hemagglutination, and Western Blot in Differentiation of Hepatic Echinococcal and Non-Echinococcal Lesions: A Retrospective Analysis of Data from a Single Referral Centre. 61
31674293 2019
25
Particles from the Echinococcus granulosus Laminated Layer Inhibit CD40 Upregulation in Dendritic Cells by Interfering with Akt Activation. 61
31570562 2019
26
Cystic echinococcosis: Development of an intermediate host rabbit model for using in vaccination studies. 61
31726054 2019
27
Disseminated cystic echinococcosis of Ferdinando II de' Medici, Grand Duke of Tuscany (1610-1670). 61
31493440 2019
28
Hepatic cystic echinococcosis due to Echinococcus granulosus, grossly observed by needle aspiration. 61
29865777 2019
29
Achievements of the HERACLES Project on Cystic Echinococcosis. 61
31753546 2019
30
Eosinophilia and cystic echinococcosis: what is the relationship? 61
31728535 2019
31
In vitro and in vivo effects of 3-bromopyruvate against Echinococcus metacestodes. 61
31744550 2019
32
Frequency and clinical presentation of alveolar and cystic echinococcosis in a tertiary medical center in Germany 2004-2018: lessons from a low-prevalence area. 61
31739373 2019
33
Epidemiology of echinococcosis in Iran: a systematic review and meta-analysis. 61
31684882 2019
34
Rapid and label-free screening of echinococcosis serum profiles through surface-enhanced Raman spectroscopy. 61
31734712 2019
35
In vitro efficacy of ampelopsin against Echinococcus granulosus and Echinococcus multilocularis. 61
31748438 2019
36
A rare case of a completely thrombosed bilobed giant intracranial aneurysm of the anterior cerebral artery with spontaneous parent vessel thrombosis: case report. 61
31759385 2019
37
Parasite-derived microRNAs in plasma as novel promising biomarkers for the early detection of hydatid cyst infection and post-surgery follow-up. 61
31682814 2019
38
Identification of antigen B (AgB) Gene polymorphism in cattle and sheep isolates of Echinococcus granulosus and investigation of effects on serological diagnosis. 61
31356785 2019
39
Ultrastructural changes in hydatid cyst walls obtained from human cases, exposed to different therapeutic approaches. 61
31578608 2019
40
First report of Echinococcus granulosus sensu stricto (G1) in Nigeria, West Africa. 61
31779721 2019
41
Human cystic echinococcosis: Serological diagnosis by indirect hemagglutination test, enzyme-linked immunosorbent assay, immunoelectrophoresis, and immunoblotting in surgically confirmed patients versus cases diagnosed by imaging techniques. 61
31727467 2019
42
Use of the ELISA (Em2-Em18) and Western Blotting Methods on Diagnosis of Alveolar Echinococcosis 61
31591873 2019
43
[Diagnostics and management of intra-abdominal Echinococcus manifestation]. 61
31312861 2019
44
Should Pediatricians Be Aware of Cystic Echinococcosis? A Literature Review. 61
31348123 2019
45
Computer Tomography (CT) Characteristics of Pulmonary Cystic Echinococcosis. 61
31819308 2019
46
The Maverick Disease: Cystic Echinococcosis in Unusual Locations: A Ten Year Experience from an Endemic Region. 61
31799081 2019
47
[Risk factors of human cystic echinococcosis in Shiqu County Sichuan Province: a case-control study]. 61
31713376 2019
48
Response to: Should Pediatricians Be Aware of Cystic Echinococcosis? A Literature Review. 61
31348122 2019
49
A clinical association between Toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: A case control study. 61
31437685 2019
50
Molecular identification of cystic echinococcosis in humans and pigs reveals the presence of both Echinococcus granulosus sensu stricto and Echinococcus canadensis G6/G7 in the hyperendemic focus of the Republic of Moldova. 61
31435765 2019
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Variations for Cystic Echinococcosis

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Expression for Cystic Echinococcosis

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Search GEO for disease gene expression data for Cystic Echinococcosis.
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Pathways for Cystic Echinococcosis

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Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.98 TLR4 TLR2 IL6 IL17A IL10 IGHE
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.29 IL6 IL17A IL10 IGHE IFNG HLA-DRB1
3
Measles 36
Show member pathways
 12.75 TLR4 TLR2 IL6 IFNG HLA-DRB1 HLA-DQB1
4
Allograft rejection 36 1
Show member pathways
 12.75 IL6 IL17A IL10 IFNG HLA-DRB1 HLA-DQB1
5
Herpes simplex virus 1 infection 36
12.73 TLR2 IL6 IFNG HLA-DRB1 HLA-DQB1 HLA-B
6
Immune response NFAT in immune response 22
Show member pathways
 12.58 IL10 IGHE IFNG HLA-DRB1 HLA-DQB1 CD40LG
7
NF-kappaB Signaling 4
12.52 TLR2 IL17A IL10 IFNG CD40LG
8
T cell receptor signaling pathway 36
Show member pathways
 12.52 TLR4 TLR2 IL6 IL17A IL10 IFNG
9
Th17 cell differentiation 36
Show member pathways
 12.46 TLR4 TLR2 IL6 IL17A IL10 IFNG
10
Human T-cell leukemia virus 1 infection 36
12.3 IL6 HLA-DRB1 HLA-DQB1 HLA-B
11
IL-17 Family Signaling Pathways 64
Show member pathways
 12.29 TLR2 IL6 IL17A IFNG
12
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.22 IL6 IL17A IL10 IFNG HLA-B
13
Colorectal Cancer Metastasis 63
12.15 TLR4 TLR2 IL6 IFNG
14
Bacterial infections in CF airways 22
Show member pathways
 12.14 TLR4 TLR2 IL6 IFNG
15
Phagosome 36
12.09 TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
16
Cell adhesion molecules (CAMs) 36
12.08 HLA-DRB1 HLA-DQB1 HLA-B CD40LG
17
Toxoplasmosis 36
Show member pathways
 12.08 TLR4 TLR2 IL10 IFNG HLA-DRB1 HLA-DQB1
18
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.99 TLR4 TLR2 IL6 IFNG
19
Th1 Differentiation Pathway 64
Show member pathways
 11.96 TLR4 TLR2 IL6 IL17A IL10 IFNG
20
Tuberculosis 36
11.96 TLR4 TLR2 IL6 IL10 IFNG HLA-DRB1
21
Interleukin-4 and 13 signaling 65
11.93 IL6 IL17A IL10 IGHE
22
Amoebiasis 36
11.88 TLR4 TLR2 IL6 IL10 IFNG
23
Hematopoietic cell lineage 36
11.86 IL6 HLA-DRB1 HLA-DQB1
24
Staphylococcus aureus infection 36
11.84 IL10 HLA-DRB1 HLA-DQB1
25
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.82 TLR4 IL6 IL17A
26
Salmonella infection (KEGG) 36
11.75 TLR4 IL6 IFNG
27
Innate Lymphoid Cell Differentiation Pathways 64
11.75 IL17A IL10 IFNG
28
Pertussis 36
11.73 TLR4 IL6 IL10
29
Dendritic Cells Developmental Lineage Pathway 64
11.71 IL6 IL10 IFNG
30
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.69 IL6 IL17A IL10 IFNG
31
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.63 IL6 IFNG CD40LG
32
IL4-mediated signaling events 1
11.62 IL10 IGHE CD40LG
33
Legionellosis 36
11.57 TLR4 TLR2 IL6
34
MSP-RON Signaling 63
11.49 TLR4 TLR2 IFNG
35
African trypanosomiasis 36
11.34 IL6 IL10 IFNG
36
IL-10 Pathway 63
11.31 TLR4 IL6 IL10
37
Development and heterogeneity of the ILC family 1
11.26 IL6 IL17A IFNG
38
Cytokines and Inflammatory Response 1
11.22 IL6 IL10 IFNG HLA-DRB1
39
Rheumatoid arthritis 36
11.14 TLR4 TLR2 IL6 IL17A IFNG HLA-DRB1
40
Malaria 36
11.13 TLR4 TLR2 IL6 IL10 IFNG CD40LG
41
Phase I biotransformations, non P450 1
10.57 CES2 CES1
Sources

GO Terms for Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 IL6 IL17A IL10 IFNG HLA-B CES2
2 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-DRB1 HLA-DQB1 HLA-B
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-B
4 external side of plasma membrane GO:0009897 9.1 TLR4 IL17A IGHE HLA-DRB1 HLA-B CD40LG

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.03 TLR4 TLR2 IGHE HLA-DRB1 HLA-DQB1 HLA-B
2 cytokine-mediated signaling pathway GO:0019221 9.93 IL6 IL17A IL10 IGHE
3 inflammatory response GO:0006954 9.85 TLR4 TLR2 IL6 IL17A IL10 CD40LG
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 TLR4 TLR2 IL6 CD40LG
5 positive regulation of interleukin-6 production GO:0032755 9.76 TLR4 TLR2 IL6
6 antigen processing and presentation GO:0019882 9.72 HLA-DRB1 HLA-DQB1 HLA-B
7 positive regulation of interleukin-6 secretion GO:2000778 9.69 TLR4 TLR2 IL17A
8 negative regulation of interferon-gamma production GO:0032689 9.67 TLR4 IL10 HLA-DRB1
9 negative regulation of interleukin-17 production GO:0032700 9.62 TLR4 IFNG
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.62 HLA-DRB1 HLA-DQB1
11 interferon-gamma-mediated signaling pathway GO:0060333 9.62 IFNG HLA-DRB1 HLA-DQB1 HLA-B
12 I-kappaB phosphorylation GO:0007252 9.61 TLR4 TLR2
13 response to molecule of bacterial origin GO:0002237 9.61 TLR2 IL10
14 positive regulation of interleukin-10 production GO:0032733 9.61 TLR4 TLR2 CD40LG
15 cellular response to lipoteichoic acid GO:0071223 9.6 TLR4 TLR2
16 T-helper 1 type immune response GO:0042088 9.59 TLR4 HLA-DRB1
17 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.58 HLA-DRB1 HLA-DQB1
18 positive regulation of chemokine production GO:0032722 9.58 TLR4 TLR2 IL6
19 positive regulation of interleukin-23 production GO:0032747 9.57 IL17A IFNG
20 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.54 HLA-DRB1 HLA-DQB1
21 positive regulation of matrix metallopeptidase secretion GO:1904466 9.48 TLR4 TLR2
22 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.46 TLR4 TLR2
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.43 TLR4 TLR2 IFNG
24 immune response GO:0006955 9.36 TLR4 TLR2 IL6 IL17A IL10 IGHE
25 positive regulation of MHC class II biosynthetic process GO:0045348 9.33 TLR4 IL10 IFNG
26 positive regulation of interleukin-12 production GO:0032735 9.26 TLR4 TLR2 IFNG CD40LG

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.37 HLA-DRB1 HLA-DQB1
2 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
3 methyl indole-3-acetate esterase activity GO:0080030 9.26 CES2 CES1
4 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.16 CES2 CES1
5 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-DQB1 HLA-B
6 cytokine activity GO:0005125 9.02 IL6 IL17A IL10 IFNG CD40LG
Sources

Sources for Cystic Echinococcosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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