MCID: CYS008
MIFTS: 50

Cystic Echinococcosis

Categories: Bone diseases, Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Cystic Echinococcosis

MalaCards integrated aliases for Cystic Echinococcosis:

Name: Cystic Echinococcosis 12 58 15
Echinococcus Granulosus Infection of Lung 12 32
Echinococcus Granulosus Infection 12 71
Echinococcus Granulosus 12 15
Echinococcus Granulosus Infectious Disease of Thyroid 12
Echinococcus Granulosus Infectious Disease of Liver 12
Echinococcus Granulosus Infection of Thyroid 12
Echinococcus Granulosus Infectious Disease 12
Thyroid Echinococcus Granulosus 12
Liver Echinococcus Granulosus 12
Lung Echinococcus Granulosus 12
Unilocular Hydatid Disease 12
Unilocular Echinococcosis 12
Hydatid Disease 58
Echinococcosis 71
Hydatidosis 58
Hydatids 54

Characteristics:

Orphanet epidemiological data:

58
cystic echinococcosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1495
ICD9CM 34 122.4
SNOMED-CT 67 75006000
ICD10 32 B67.1 B67.4
MESH via Orphanet 44 D004443
UMLS via Orphanet 72 C0013502
Orphanet 58 ORPHA400
UMLS 71 C0013502 C0152068

Summaries for Cystic Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary : Cystic Echinococcosis, also known as echinococcus granulosus infection of lung, is related to clonorchiasis and alveolar echinococcosis. An important gene associated with Cystic Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Metronidazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung, and related phenotypes are digestive/alimentary and liver/biliary system

Related Diseases for Cystic Echinococcosis

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 896)
# Related Disease Score Top Affiliating Genes
1 clonorchiasis 31.0 IL10 IGHE IFNG
2 alveolar echinococcosis 30.7 TLR4 TLR2 MT-CO1 HLA-DRB1 HLA-DQB1 HLA-B
3 pleurisy 30.6 TLR4 TLR2 IFNG
4 angioedema 30.6 IL6 IGHE CD40LG
5 coenurosis 30.4 MT-ND1 MT-CO1
6 mouth disease 30.4 TLR4 IL6 IL10 IFNG
7 diarrhea 30.3 TLR4 IL6 IL10 IFNG CD40LG
8 tetanus 30.2 IL6 IL10 IFNG CD40LG
9 strongyloidiasis 30.2 IGHE IFNG CD40LG
10 lung abscess 30.2 IL6 IFNG CD40LG
11 urticaria 30.2 IL6 IGHE CD40LG
12 peritonitis 30.1 TLR4 TLR2 IL6 IL10 IFNG
13 visceral leishmaniasis 30.1 TLR4 TLR2 IL10 IFNG HLA-DRB1
14 radiculopathy 30.1 IL6 IL17A IL10
15 infective endocarditis 30.1 TLR2 IL6 IL17A
16 spastic paraparesis 30.0 IL10 IFNG HLA-B
17 amebiasis 30.0 TLR4 TLR2 IL17A CD40LG
18 keratitis, hereditary 30.0 TLR4 TLR2 IL6 IL17A IL10
19 syphilis 30.0 IL17A IGHE HLA-DRB1 CD40LG
20 sparganosis 30.0 MT-ND1 MT-CO1
21 fascioliasis 30.0 MT-ND1 MT-CO1 IL10 IFNG
22 pericarditis 30.0 IL6 IFNG CD40LG
23 suppurative otitis media 30.0 TLR4 TLR2 CD40LG
24 osteomyelitis 29.9 TLR4 TLR2 IL6 IL10 IFNG
25 eosinophilic meningitis 29.9 IL10 IGHE CD40LG
26 guillain-barre syndrome 29.9 HLA-DRB1 HLA-DQB1 CD40LG
27 bronchopneumonia 29.9 TLR4 IL6 IL10 CD40LG
28 atrophic gastritis 29.9 IL6 IL10 HLA-DRB1
29 exanthem 29.9 IL6 IL10 CD40LG
30 aspiration pneumonia 29.8 IL6 IL17A CD40LG
31 cellulitis 29.8 IL6 IL10 CD40LG
32 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.8 IL17A IL10 IFNG
33 sclerosing cholangitis 29.7 TLR4 IL6 IL10 HLA-DRB1 HLA-B CD40LG
34 autoimmune hepatitis 29.7 IL10 HLA-DRB1 HLA-DQB1 CD40LG
35 lupus erythematosus 29.7 IL10 IFNG HLA-DRB1 HLA-DQB1 CD40LG
36 lymphadenitis 29.7 TLR4 IL10 IFNG
37 cryptococcosis 29.7 IL17A IL10 IFNG
38 duodenal ulcer 29.7 TLR4 IL6 IL10 HLA-DRB1
39 gastritis 29.7 TLR4 IL6 IL17A IL10
40 schistosomiasis 29.7 IL17A IL10 IGHE IFNG CD40LG
41 acute chest syndrome 29.7 HLA-DRB1 HLA-DQB1 CD40LG
42 allergic hypersensitivity disease 29.7 TLR4 TLR2 IL17A IL10 IGHE IFNG
43 invasive aspergillosis 29.7 TLR4 TLR2 IL10 IFNG
44 aspergillosis 29.6 TLR4 TLR2 IL6 IL10 IFNG
45 mastitis 29.6 TLR2 IL6 IL17A
46 allergic bronchopulmonary aspergillosis 29.6 IL10 IGHE IFNG HLA-DRB1
47 pyelonephritis 29.6 TLR4 IL6 IL10 IFNG
48 alcoholic liver cirrhosis 29.6 TLR4 TLR2 IL6 IL10
49 cysticercosis 29.6 TLR4 MT-ND1 MT-CO1 IL6 IL10 IGHE
50 spondyloarthropathy 1 29.5 TLR4 IL17A HLA-B CD40LG

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

MGI Mouse Phenotypes related to Cystic Echinococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 HLA-DQB1 IFNG IL10 IL17A IL6 TLR2
2 liver/biliary system MP:0005370 9.7 CES1 HLA-DQB1 IFNG IL10 IL6 TLR2
3 renal/urinary system MP:0005367 9.56 CD40LG CES1 HLA-DQB1 IFNG IL17A IL6
4 respiratory system MP:0005388 9.17 HLA-DQB1 IFNG IL10 IL17A IL6 TLR2

Drugs & Therapeutics for Cystic Echinococcosis

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Iodine Approved, Investigational 7553-56-2 807
3
Mebendazole Approved, Vet_approved 31431-39-7 4030
4
Albendazole Approved, Vet_approved 54965-21-8 2082
5 Benzimidazole Experimental, Investigational 51-17-2
6 Hematinics
7 cadexomer iodine
8 Liver Extracts
9 Antiparasitic Agents
10 Anthelmintics
11 Anti-Infective Agents
12 Antimitotic Agents
13 Antiprotozoal Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
2 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
3 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
4 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
5 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
6 Risk Factors for Major Complications After Liver Resection: Audit of a Non-Eastern/Non-Western Experience Completed NCT03967067
7 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
8 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Recruiting NCT03289884
9 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
10 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Liver Disease Recruiting NCT03354247
11 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole

Genetic Tests for Cystic Echinococcosis

Anatomical Context for Cystic Echinococcosis

MalaCards organs/tissues related to Cystic Echinococcosis:

40
Liver, Thyroid, Lung, Heart, Bone, Kidney, Testes

Publications for Cystic Echinococcosis

Articles related to Cystic Echinococcosis:

(show top 50) (show all 1722)
# Title Authors PMID Year
1
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. 54 61
18692060 2008
2
Echinococcus granulosus in Jordan: assessment of various antigenic preparations for use in the serodiagnosis of surgically confirmed cases using enzyme immuno assays and the indirect haemagglutination test. 54 61
14972381 2004
3
Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. 54 61
15198645 2004
4
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates. 54 61
12197890 2002
5
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. 54 61
11119517 2001
6
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. 54 61
11116435 2000
7
Immunoglobulin G subclass responses in human cystic and alveolar echinococcosis. 54 61
7810806 1994
8
Epidemiologic-economic models and the One Health paradigm: echinococcosis and leishmaniasis, case studies in Veneto region, Northeastern Italy. 61
32021898 2020
9
Arginase promotes immune evasion of Echinococcus granulosus in mice. 61
32029006 2020
10
Multiple haplotypes of Echinococcus granulosus sensu stricto in single naturally infected intermediate hosts. 61
31863181 2020
11
Parasite-derived microRNAs in plasma as novel promising biomarkers for the early detection of hydatid cyst infection and post-surgery follow-up. 61
31682814 2020
12
Study on the association between TGF-β1 and liver fibrosis in patients with hepatic cystic echinococcosis. 61
32010299 2020
13
Single-Center Study: Evaluating the Diagnostic Performance and Safety of Contrast-Enhanced Ultrasound (CEUS) in Pregnant Women to Assess Hepatic Lesions. 61
31362328 2020
14
Microwave ablation combining surgery for the treatment of multiorgan cystic echinococcosis: A case report. 61
31026594 2020
15
Soluble ST2 (sST2) as potential marker for hepatic cystic echinococcosis activity. 61
32027871 2020
16
Imported hepatopulmonary echinococcosis: first report of Echinococcus granulosus sensu stricto (G1) in Bolivia. 61
31994653 2020
17
Development of a copro-LAMP assay for detection of several species of Echinococcus granulosus sensu lato complex. 61
31901535 2020
18
Lymphocyte Populations in the Adventitial Layer of Hydatid Cysts in Cattle: Relationship With Cyst Fertility Status and Fasciola Hepatica Co-Infection. 61
31526120 2020
19
The combination of Cytokines and albendazole therapy for prophylaxis and treatment of experimental/hydatid cyst. 61
31586448 2020
20
Incidence Rates of Surgically Managed Cystic Echinococcosis in Kazakhstan, 2007-2016. 61
31802731 2020
21
Cystic echinococcosis: Development of an intermediate host rabbit model for using in vaccination studies. 61
31726054 2020
22
Seroprevalence of cystic echinococcosis in the provinces of Ifrane and El Hajeb in Morocco. 61
31928912 2020
23
Analysis of Factors Influencing Cystic Echinococcosis in Northwest Non-Qinghai Tibetan Plateau Regions of China. 61
31933454 2020
24
Surgically confirmed cases of cystic echinococcosis from Baluchistan Province, Pakistan for the years 2011-2018. 61
31982433 2020
25
Comment on: "Complications Associated with Initial Clinical Presentation of Cystic Echinococcosis: A 20-year Cohort Analysis". 61
31971161 2020
26
Identification of potential 'hot spots' of cystic echinococcosis transmission in the province of Río Negro, Argentina. 61
31954134 2020
27
Isolated muscular cystic echinococcosis mimicking neoplasia. 61
31943057 2020
28
Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens With Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis. 61
31567204 2020
29
Cystic and alveolar echinococcosis are two completely different diseases caused by two different species of Echinococcus parasites. comment ON: Disseminated cystic echinococcosis of Ferdinando II de' Medici, Grand Duke of Tuscany (1610-1670) by Gaeta R, Giuffra V. J infect. 2019 Sep 4. 61
31541664 2020
30
Rapid and label-free screening of echinococcosis serum profiles through surface-enhanced Raman spectroscopy. 61
31734712 2020
31
Co-existence of hepatocellular carcinoma and cystic echinococcosis. 61
32010203 2020
32
A hyperendemic focus of porcine cystic echinococcosis in the Banke District of Nepal. 61
31574252 2020
33
Achievements of the HERACLES Project on Cystic Echinococcosis. 61
31753546 2020
34
Eosinophilia and cystic echinococcosis: what is the relationship? 61
31728535 2020
35
Genetic survey of cystic echinococcosis in farm animals in Oman. 61
31338730 2020
36
Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid from patients: isolation, characterization and evaluation of immunomodulatory functions on T cells. 61
31734339 2019
37
Executive Summary of the Consensus Statement of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Tropical Medicine and International Health (SEMTSI), the Spanish Association of Surgeons (AEC), the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), the Spanish Society of Thoracic Surgery (SECT), the Spanish Society of Vascular and Interventional Radiology (SERVEI), and the Spanish Society of Paediatric Infectious Diseases (SEIP), on the Management of Cystic Echinococcosis. 61
31866064 2019
38
Particles from the Echinococcus granulosus Laminated Layer Inhibit CD40 Upregulation in Dendritic Cells by Interfering with Akt Activation. 61
31570562 2019
39
In vitro anti-echinococcal activity of octreotide: Additive effect of metformin linked to autophagy. 61
31870710 2019
40
Detection of Echinococcus granulosus sensu lato infection by using extracts derived from a protoscoleces G1 cell line. 61
31557338 2019
41
Genotyping of human Echinococcus granulosus cyst in Morocco. 61
31749525 2019
42
Role of stellate cells in hepatic echinococcosis in cattle. 61
31749527 2019
43
Genetic variation of Echinococcus spp. in yaks and sheep in the Tibet Autonomous Region of China based on mitochondrial DNA. 61
31881922 2019
44
Diagnostic Performances of Commercial ELISA, Indirect Hemagglutination, and Western Blot in Differentiation of Hepatic Echinococcal and Non-Echinococcal Lesions: A Retrospective Analysis of Data from a Single Referral Centre. 61
31674293 2019
45
Huge peliosis hepatis mimicking cystic echinococcosis: A case report. 61
31860961 2019
46
Control of cystic echinococcosis: Background and prospects. 61
31529690 2019
47
Disease burden of echinococcosis in Tibetan communities-A significant public health issue in an underdeveloped region of western China. 61
31811863 2019
48
Species specificity preliminary evaluation of an IL-4-based test for the differential diagnosis of human echinococcosis. 61
31884696 2019
49
In vitro efficacy of ampelopsin against Echinococcus granulosus and Echinococcus multilocularis. 61
31748438 2019
50
Potential role of NF-κB pathway in the immuno-inflammatory responses during human cystic echinococcosis. 61
31891707 2019

Variations for Cystic Echinococcosis

Expression for Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for Cystic Echinococcosis

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TLR4 TLR2 IL6 IL17A IL10 IGHE
2
Show member pathways
13.29 IL6 IL17A IL10 IGHE IFNG HLA-DRB1
3
Show member pathways
12.75 TLR4 TLR2 IL6 IFNG HLA-DRB1 HLA-DQB1
4
Show member pathways
12.75 IL6 IL17A IL10 IFNG HLA-DRB1 HLA-DQB1
5 12.73 TLR2 IL6 IFNG HLA-DRB1 HLA-DQB1 HLA-B
6
Show member pathways
12.58 IL10 IGHE IFNG HLA-DRB1 HLA-DQB1 CD40LG
7 12.52 TLR2 IL17A IL10 IFNG CD40LG
8
Show member pathways
12.52 TLR4 TLR2 IL6 IL17A IL10 IFNG
9
Show member pathways
12.46 TLR4 TLR2 IL6 IL17A IL10 IFNG
10 12.3 IL6 HLA-DRB1 HLA-DQB1 HLA-B
11
Show member pathways
12.29 TLR2 IL6 IL17A IFNG
12
Show member pathways
12.22 IL6 IL17A IL10 IFNG HLA-B
13 12.15 TLR4 TLR2 IL6 IFNG
14
Show member pathways
12.14 TLR4 TLR2 IL6 IFNG
15 12.09 TLR4 TLR2 HLA-DRB1 HLA-DQB1 HLA-B
16 12.08 HLA-DRB1 HLA-DQB1 HLA-B CD40LG
17
Show member pathways
12.08 TLR4 TLR2 IL10 IFNG HLA-DRB1 HLA-DQB1
18
Show member pathways
11.99 TLR4 TLR2 IL6 IFNG
19
Show member pathways
11.96 TLR4 TLR2 IL6 IL17A IL10 IFNG
20 11.96 TLR4 TLR2 IL6 IL10 IFNG HLA-DRB1
21 11.93 IL6 IL17A IL10 IGHE
22 11.88 TLR4 TLR2 IL6 IL10 IFNG
23 11.86 IL6 HLA-DRB1 HLA-DQB1
24 11.84 IL10 HLA-DRB1 HLA-DQB1
25
Show member pathways
11.82 TLR4 IL6 IL17A
26 11.75 TLR4 IL6 IFNG
27 11.75 IL17A IL10 IFNG
28 11.73 TLR4 IL6 IL10
29 11.71 IL6 IL10 IFNG
30 11.69 IL6 IL17A IL10 IFNG
31
Show member pathways
11.63 IL6 IFNG CD40LG
32 11.62 IL10 IGHE CD40LG
33 11.57 TLR4 TLR2 IL6
34 11.49 TLR4 TLR2 IFNG
35 11.34 IL6 IL10 IFNG
36 11.31 TLR4 IL6 IL10
37 11.26 IL6 IL17A IFNG
38 11.22 IL6 IL10 IFNG HLA-DRB1
39 11.14 TLR4 TLR2 IL6 IL17A IFNG HLA-DRB1
40 11.13 TLR4 TLR2 IL6 IL10 IFNG CD40LG
41 10.57 CES2 CES1

GO Terms for Cystic Echinococcosis

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 IL6 IL17A IL10 IFNG HLA-B CES2
2 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-DRB1 HLA-DQB1 HLA-B
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-B
4 external side of plasma membrane GO:0009897 9.1 TLR4 IL17A IGHE HLA-DRB1 HLA-B CD40LG

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.03 TLR4 TLR2 IGHE HLA-DRB1 HLA-DQB1 HLA-B
2 cytokine-mediated signaling pathway GO:0019221 9.93 IL6 IL17A IL10 IGHE
3 inflammatory response GO:0006954 9.85 TLR4 TLR2 IL6 IL17A IL10 CD40LG
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 TLR4 TLR2 IL6 CD40LG
5 positive regulation of interleukin-6 production GO:0032755 9.76 TLR4 TLR2 IL6
6 antigen processing and presentation GO:0019882 9.72 HLA-DRB1 HLA-DQB1 HLA-B
7 positive regulation of interleukin-6 secretion GO:2000778 9.69 TLR4 TLR2 IL17A
8 negative regulation of interferon-gamma production GO:0032689 9.67 TLR4 IL10 HLA-DRB1
9 negative regulation of interleukin-17 production GO:0032700 9.62 TLR4 IFNG
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.62 HLA-DRB1 HLA-DQB1
11 interferon-gamma-mediated signaling pathway GO:0060333 9.62 IFNG HLA-DRB1 HLA-DQB1 HLA-B
12 I-kappaB phosphorylation GO:0007252 9.61 TLR4 TLR2
13 response to molecule of bacterial origin GO:0002237 9.61 TLR2 IL10
14 positive regulation of interleukin-10 production GO:0032733 9.61 TLR4 TLR2 CD40LG
15 cellular response to lipoteichoic acid GO:0071223 9.6 TLR4 TLR2
16 T-helper 1 type immune response GO:0042088 9.59 TLR4 HLA-DRB1
17 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.58 HLA-DRB1 HLA-DQB1
18 positive regulation of chemokine production GO:0032722 9.58 TLR4 TLR2 IL6
19 positive regulation of interleukin-23 production GO:0032747 9.57 IL17A IFNG
20 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.54 HLA-DRB1 HLA-DQB1
21 positive regulation of matrix metallopeptidase secretion GO:1904466 9.48 TLR4 TLR2
22 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.46 TLR4 TLR2
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.43 TLR4 TLR2 IFNG
24 immune response GO:0006955 9.36 TLR4 TLR2 IL6 IL17A IL10 IGHE
25 positive regulation of MHC class II biosynthetic process GO:0045348 9.33 TLR4 IL10 IFNG
26 positive regulation of interleukin-12 production GO:0032735 9.26 TLR4 TLR2 IFNG CD40LG

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.37 HLA-DRB1 HLA-DQB1
2 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
3 methyl indole-3-acetate esterase activity GO:0080030 9.26 CES2 CES1
4 methylumbelliferyl-acetate deacetylase activity GO:0047374 9.16 CES2 CES1
5 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-DQB1 HLA-B
6 cytokine activity GO:0005125 9.02 IL6 IL17A IL10 IFNG CD40LG

Sources for Cystic Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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