CFM1
MCID: CYS047
MIFTS: 16

Cystic Fibrosis, Modifier of, 1 (CFM1)

Categories: Fetal diseases

Aliases & Classifications for Cystic Fibrosis, Modifier of, 1

MalaCards integrated aliases for Cystic Fibrosis, Modifier of, 1:

Name: Cystic Fibrosis, Modifier of, 1 56
Meconium Ileus in Cystic Fibrosis 56 32
Meconium Ileus in Cystic Fibrosis, Susceptibility to 56
Cystic Fibrosis Modifier-1 13
Cystic Fibrosis Modifier 1 71
Cfm1 56

Classifications:



External Ids:

OMIM 56 603855
ICD10 32 P75
MedGen 41 C1859047
SNOMED-CT via HPO 68 206523001 233662009 86092005
UMLS 71 C1859047

Summaries for Cystic Fibrosis, Modifier of, 1

MalaCards based summary : Cystic Fibrosis, Modifier of, 1, also known as meconium ileus in cystic fibrosis, is related to cystic fibrosis and meconium ileus. An important gene associated with Cystic Fibrosis, Modifier of, 1 is CFM1 (Cystic Fibrosis Modifier 1). Affiliated tissues include lung, and related phenotype is meconium ileus.

More information from OMIM: 603855

Related Diseases for Cystic Fibrosis, Modifier of, 1

Diseases related to Cystic Fibrosis, Modifier of, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cystic fibrosis 11.4
2 meconium ileus 11.2
3 ileus 10.6
4 fibrosis of extraocular muscles, congenital, 1 10.5
5 intestinal obstruction 10.2
6 lung disease 10.2

Graphical network of the top 20 diseases related to Cystic Fibrosis, Modifier of, 1:



Diseases related to Cystic Fibrosis, Modifier of, 1

Symptoms & Phenotypes for Cystic Fibrosis, Modifier of, 1

Human phenotypes related to Cystic Fibrosis, Modifier of, 1:

31
# Description HPO Frequency HPO Source Accession
1 meconium ileus 31 HP:0004401

Clinical features from OMIM:

603855

Drugs & Therapeutics for Cystic Fibrosis, Modifier of, 1

Search Clinical Trials , NIH Clinical Center for Cystic Fibrosis, Modifier of, 1

Genetic Tests for Cystic Fibrosis, Modifier of, 1

Anatomical Context for Cystic Fibrosis, Modifier of, 1

MalaCards organs/tissues related to Cystic Fibrosis, Modifier of, 1:

40
Lung

Publications for Cystic Fibrosis, Modifier of, 1

Articles related to Cystic Fibrosis, Modifier of, 1:

(show all 15)
# Title Authors PMID Year
1
Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. 56
20047061 2010
2
Modifier genes in mice and humans. 56
11256068 2001
3
Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13. 56
10369249 1999
4
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor. 56
8589719 1996
5
Clinical and genetic comparisons of patients with cystic fibrosis, with or without meconium ileus. 56
2715890 1989
6
Meconium ileus in Cystic Fibrosis. 61
28986020 2017
7
Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1). 61
28420732 2017
8
Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3(-) transport and reduces survival in CFTR-deficient mice. 61
24965066 2015
9
Meconium ileus in cystic fibrosis is not linked to central repetitive region length variation in MUC1, MUC2, and MUC5AC. 61
24920497 2014
10
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. 61
23676501 2013
11
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. 61
22466613 2012
12
Long-term pulmonary outcome after meconium ileus in cystic fibrosis. 61
19911366 2009
13
Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. 61
19662435 2009
14
New strategies in nonoperative management of meconium ileus. 61
11987095 2002
15
Meconium ileus in cystic fibrosis fetuses. 61
6146775 1984

Variations for Cystic Fibrosis, Modifier of, 1

Expression for Cystic Fibrosis, Modifier of, 1

Search GEO for disease gene expression data for Cystic Fibrosis, Modifier of, 1.

Pathways for Cystic Fibrosis, Modifier of, 1

GO Terms for Cystic Fibrosis, Modifier of, 1

Sources for Cystic Fibrosis, Modifier of, 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....