MCID: CYS017
MIFTS: 42

Cystic Teratoma

Categories: Cancer diseases

Aliases & Classifications for Cystic Teratoma

MalaCards integrated aliases for Cystic Teratoma:

Name: Cystic Teratoma 12 15 71
Benign Teratoma 71
Dermoid Cyst 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2660
NCIt 49 C9014
SNOMED-CT 67 42717009
UMLS 71 C0011649 C1368903 C1879828

Summaries for Cystic Teratoma

Disease Ontology : 12 A benign teratoma that is characterized by the presence of cysts or cystic spaces.

MalaCards based summary : Cystic Teratoma, also known as benign teratoma, is related to ovarian cystic teratoma and benign teratoma. An important gene associated with Cystic Teratoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Gastric cancer and Human T-cell leukemia virus 1 infection. The drugs Palbociclib and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and lung, and related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Cystic Teratoma

Diseases in the Cystic Teratoma family:

Adult Cystic Teratoma

Diseases related to Cystic Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 770)
# Related Disease Score Top Affiliating Genes
1 ovarian cystic teratoma 34.1 SYP NKX2-1 AFP
2 benign teratoma 31.3 SYP NKX2-1 MIR520D KRT7 KRT20 ENO2
3 mucinous cystadenocarcinoma 31.1 MUC16 KRT7 KRT20
4 ovarian brenner tumor 31.0 MUC16 KRT7 KRT20
5 appendix adenocarcinoma 30.9 SYP KRT7 KRT20 KRAS CDX2
6 struma ovarii 30.8 NKX2-1 MUC16 KRAS
7 thyroid carcinoma 30.8 TP53 PTEN NKX2-1
8 cystadenocarcinoma 30.8 TP53 MUC5AC MUC16 KRT7
9 intestinal obstruction 30.7 KRT7 KRT20 KIT CDX2
10 in situ carcinoma 30.6 TP53 PTEN CDKN2A
11 mammary paget's disease 30.5 KRT7 KRT20 KRT18
12 benign ependymoma 30.4 SYP GFAP ENO2
13 leiomyosarcoma 30.4 TP53 KIT ENO2 CDKN2A
14 adenofibroma 30.4 TP53 MUC16 KRT7 CALB2
15 ovarian germ cell teratoma 30.4 SYP NKX2-1 KRT7 CALB2 AFP
16 malignant syringoma 30.4 KRT7 KRT20
17 mature teratoma 30.4 TP53 SYP KRT7 KRAS KIT AFP
18 neuroendocrine tumor 30.4 SYP NKX2-1 KRT20 ENO2 CDX2
19 ganglioneuroblastoma 30.3 TP53 SYP ENO2
20 carcinoid tumors, intestinal 30.3 SYP NKX2-1 ENO2
21 papillary carcinoma 30.3 SYP NKX2-1 KRT7 KRT20 CALB2
22 gangliocytoma 30.3 SYP PTEN GFAP
23 sweat gland cancer 30.2 TP53 SYP KRT7 KRT20
24 spinal cancer 30.2 SYP GFAP ENO2
25 histiocytoma 30.2 TP53 KIT ENO2 CDKN2A
26 central neurocytoma 30.2 SYP GFAP ENO2
27 mature teratoma of the ovary 30.2 SYP ENO2 AFP
28 papilloma of choroid plexus 30.2 TP53 SYP KRT7 GFAP ENO2
29 polycystic liver disease 1 with or without kidney cysts 30.2 MUC16 KRT7 KRT20 CALB2
30 granulosa cell tumor of the ovary 30.2 TP53 SYP KRT7 ENO2
31 myoma 30.2 MUC16 KRAS KIT
32 liposarcoma 30.2 TP53 PTEN CDKN2A CALB2
33 paraganglioma 30.1 SYP KIT GFAP ENO2
34 dermoid cyst of ovary 30.1 CALB2 AFP
35 angiosarcoma 30.1 TP53 KRT7 KRAS KIT CALB2
36 serous cystadenocarcinoma 30.1 TP53 PTEN MUC16 KRAS
37 pneumothorax 30.1 NKX2-1 GFAP CALB2
38 adenocarcinoma in situ 30.1 KRT7 KRT20 KRAS CDX2 CDKN2A
39 central nervous system primitive neuroectodermal neoplasm 30.1 TP53 SYP GFAP ENO2
40 ovarian mucinous adenocarcinoma 30.1 MUC5AC KRT7 KRT20 CDX2
41 endodermal sinus tumor 30.0 MUC16 KIT AFP
42 ganglioneuroma 30.0 SYP PTEN GFAP ENO2
43 ovarian mucinous neoplasm 30.0 MUC5AC KRT7 KRT20 KRAS CDX2
44 malignant teratoma 29.9 SYP KIT ENO2 AFP
45 oligodendroglioma 29.9 TP53 SYP PTEN GFAP ENO2 CDKN2A
46 mixed germ cell tumor 29.8 KIT AFP
47 ewing sarcoma 29.8 TP53 SYP KIT ENO2 CDKN2A
48 hydrocephalus 29.8 TP53 SYP PTEN GFAP ENO2
49 leydig cell tumor 29.7 SYP CALB2 AFP
50 granular cell tumor 29.7 SYP NKX2-1 GFAP ENO2 CALB2

Graphical network of the top 20 diseases related to Cystic Teratoma:



Diseases related to Cystic Teratoma

Symptoms & Phenotypes for Cystic Teratoma

GenomeRNAi Phenotypes related to Cystic Teratoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 AFP CALB2 CDKN2A GFAP KIT KRAS

MGI Mouse Phenotypes related to Cystic Teratoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 AFP CALB2 CDKN2A ENO2 GFAP KIT
2 digestive/alimentary MP:0005381 9.81 CDKN2A CDX2 GFAP KIT KRAS MUC5AC
3 neoplasm MP:0002006 9.56 AFP CDKN2A CDX2 KIT KRAS NKX2-1
4 normal MP:0002873 9.28 CALB2 CDX2 GFAP KIT KRAS NKX2-1

Drugs & Therapeutics for Cystic Teratoma

Drugs for Cystic Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
nivolumab Approved Phase 2 946414-94-4
4
Ipilimumab Approved Phase 2 477202-00-9
5 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Antineoplastic Agents, Immunological Phase 2
8 Antibodies, Monoclonal Phase 2
9 Antibodies Phase 2
10 Immunoglobulins Phase 2
11
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
12 Anesthetics
13 Central Nervous System Depressants
14 Adjuvants, Immunologic
15 Protective Agents
16 Immunologic Factors
17 Viscosupplements
18 Carboxymethylcellulose Sodium

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-Port Compared With Conventional Laparoscopic Cystectomy for Ovarian Dermoid Cysts Completed NCT02009228 Phase 3
2 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Recruiting NCT01037790 Phase 2 PD-0332991
3 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
4 Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries: Prospective Randomized Trials Unknown status NCT02580500
5 Mesial Incision for Laparoscopic Dermoid Cystectomy: a New Safe and Fertility-sparing Technique Completed NCT01590030
6 A Non-randomized Controlled Clinical Trial of Corneal Epithelial Autograft for Limbal Dermoid Recruiting NCT03217461
7 The Assessment of the Use of Anti-Adhesion Agents to Prevent Pelvic Postoperative Adhesions Recruiting NCT04063085
8 Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence Not yet recruiting NCT03823833

Search NIH Clinical Center for Cystic Teratoma

Genetic Tests for Cystic Teratoma

Anatomical Context for Cystic Teratoma

MalaCards organs/tissues related to Cystic Teratoma:

40
Ovary, Thyroid, Lung, Breast, Colon, Pancreas, Testis

Publications for Cystic Teratoma

Articles related to Cystic Teratoma:

(show top 50) (show all 3809)
# Title Authors PMID Year
1
Atypical dermoid cyst of the ovary during pregnancy: A multi-modality diagnostic approach. 61
31956391 2020
2
Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success. 61
31828777 2020
3
Surgical Treatment of Massive Teratoma of the Orbit. 61
32022750 2020
4
[Analysis of solid ovarian tumours in a Spanish paediatric population]. 61
30975583 2020
5
Meningioma in mature cystic teratoma of the ovary: clinical and computed tomography findings. 61
32024553 2020
6
Sellar surprises: a single-centre experience of unusual sellar masses. 61
31910151 2020
7
Patient with Epilepsy Caused by the Spontaneous Rupture of an Intracerebral Dermoid Cyst. 61
31954900 2020
8
Midline Intranasal Dermoid Cyst With Intracranial Extension: Technical Details of a Multidisciplinary Approach to a Rare Condition. 61
31985595 2020
9
Extragonadal mature cystic teratoma at anterior uterine wall coexisting with a pararectal corpus luteum cyst and agenesis of left fallopian tube and left ovary. 61
32039786 2020
10
Quantitative analysis of ovarian cysts and tumors by using T2 star mapping. 61
31742851 2020
11
Wilms Tumor of the Ovary: Review of the Literature and Report of 2 Cases. 61
31815892 2020
12
Pressure ulcer following circumferential head dressing. 61
31997678 2020
13
A Large Dermoid Cyst Causing Plagiocephaly. 61
31977706 2020
14
Nonodontogenic Cysts. 61
31735234 2020
15
Nasal dermoid cysts with intracranial extension: avoiding coronal incision through midline exposure and nasal bone osteotomy. 61
31812133 2019
16
Intracranial growing teratoma syndrome observed at 44 months after initial treatment; a case presentation and literature review. 61
31853895 2019
17
A Mature Cystic Teratoma of the Urinary Bladder. 61
31779776 2019
18
Rare giant: mature cystic teratoma in the liver. 61
31832137 2019
19
Sonographic appearances of retained surgical sponges in the abdomen and pelvis. 61
31867725 2019
20
Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis. 61
31938630 2019
21
A Case of Pseudo-Meigs Syndrome Caused by a Giant Uterine Leiomyoma with Cystic Degeneration. 61
31902853 2019
22
Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature. 61
31679038 2019
23
Rare Case of Giant Supratentorial Dermoid Cyst. 61
31821914 2019
24
Lateral rectus dermoid cyst presenting as incomitant esotropia. 61
30691358 2019
25
Diagnosis and Treatment of Scalp Arteriovenous Malformations With Intracranial Extension. 61
31403511 2019
26
Caecal dermoid cyst presenting as an appendicular mucocele on abdominal imaging. 61
31516651 2019
27
Differentiation of sublingual thyroglossal duct cyst from midline dermoid cyst with diffusion weighted imaging. 61
31400658 2019
28
Explosion of dermoid cyst into five intracranial spaces- a rare event. 61
31713448 2019
29
Ovarian Intermediate Trophoblastic Tumors: Genotyping Defines a Distinct Category of Nongestational Tumors of Germ Cell Type. 61
31688005 2019
30
Laparoscopic simultaneous resection of bilateral giant primary mature retroperitoneal teratoma of the adrenal region: A case report. 61
31689872 2019
31
Primary malignant melanoma arising from ruptured ovarian mature cystic teratoma with elevated serum CA 19-9: a case report and review of literature. 61
31775731 2019
32
Mature cystic teratoma arising from the fimbrial end of the left fallopian tube. a case report. 61
31684783 2019
33
Ocular Adnexal Racemose Cysticercosis Masquerading as Dermoid Cyst. 61
30882589 2019
34
Spinal Intradural Extramedullary Dermoid Cyst. 61
31759148 2019
35
[Clinical features and pathological analysis of lacrimal gland occupying lesions in 91 cases]. 61
31715681 2019
36
Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. 61
31776717 2019
37
[Orbital Disorders in Childhood]. 61
31412385 2019
38
Mechanisms of C-myc oncogenic activity in head and neck squamous cell carcinoma. 61
31983089 2019
39
Whole spine MRI is not required in investigating uncomplicated paediatric lumbosacral lipoma. A retrospective single-institution review. 61
31502036 2019
40
Pilomatrixoma: A Rare Cause of Midline Neck Swelling. 61
31659972 2019
41
Subcutaneous dermoid cysts on the eyebrow and neck. 61
31414508 2019
42
Nasal Congenital Panfollicular Nevus. 61
31763229 2019
43
Pediatric congenital buttock sinus tract:10-year experience in a single institution. 61
31690282 2019
44
Unusual intrascrotal lesions in adults in urological practice. 61
31697257 2019
45
Orbital and periorbital dermoid/epidermoid cyst: a series of 280 cases and a brief review. 61
31712044 2019
46
Generalised purulent peritonitis and small bowel obstruction due to a spontaneously perforated ovarian dermoid cyst. 61
31645380 2019
47
Fimbrial dermoid cyst with elevated CA19-9 levels: A case report. 61
31871902 2019
48
Huge ovarian mature cystic teratoma with gliomatosis peritonei and massive ascites in a postmenopausal woman. 61
31867262 2019
49
Comparison between Laparoendoscopic Single-Site and Conventional Laparoscopic Surgery in Mature Cystic Teratoma of the Ovary. 61
31741840 2019
50
Primary Squamous Cell Carcinoma of the Ovary. 61
31772854 2019

Variations for Cystic Teratoma

Expression for Cystic Teratoma

Search GEO for disease gene expression data for Cystic Teratoma.

Pathways for Cystic Teratoma

Pathways related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 TP53 PTEN KRAS KIT CDX2 CDKN2A
2 12.01 TP53 PTEN KRAS CDKN2A
3 11.83 TP53 PTEN KRAS CDKN2A
4 11.62 TP53 PTEN KRAS CDKN2A
5 11.5 TP53 PTEN KRAS CDKN2A
6 11.44 TP53 KRAS CDKN2A
7 10.76 TP53 PTEN KRAS KIT

GO Terms for Cystic Teratoma

Cellular components related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.02 KRT7 KRT20 KRT18 KRT10 GFAP

Biological processes related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.62 KRT7 KRT20 KRT18 KRT10
2 regulation of protein stability GO:0031647 9.61 PTEN KRAS CDKN2A
3 Ras protein signal transduction GO:0007265 9.54 TP53 KRAS CDKN2A
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.46 MUC6 MUC5AC MUC16 KRAS
5 O-glycan processing GO:0016266 9.43 MUC6 MUC5AC MUC16
6 somatic stem cell division GO:0048103 9.4 KIT CDKN2A
7 cornification GO:0070268 9.26 KRT7 KRT20 KRT18 KRT10
8 positive regulation of gene expression GO:0010628 9.1 TP53 PTEN NKX2-1 KRAS KIT CDKN2A

Sources for Cystic Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....