MCID: CYS017
MIFTS: 38

Cystic Teratoma

Categories: Cancer diseases

Aliases & Classifications for Cystic Teratoma

MalaCards integrated aliases for Cystic Teratoma:

Name: Cystic Teratoma 12 15 72
Benign Teratoma 72
Dermoid Cyst 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2660
NCIt 50 C9014
SNOMED-CT 68 42717009
UMLS 72 C0011649 C1368903 C1879828

Summaries for Cystic Teratoma

Disease Ontology : 12 A teratoma that is characterized by the presence of cysts or cystic spaces.

MalaCards based summary : Cystic Teratoma, also known as benign teratoma, is related to ovarian cystic teratoma and dermoid cyst. An important gene associated with Cystic Teratoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Neuroscience and TP53 Network. The drugs Cisplatin and Palbociclib have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and pancreas.

Related Diseases for Cystic Teratoma

Diseases in the Cystic Teratoma family:

Adult Cystic Teratoma

Diseases related to Cystic Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 575)
# Related Disease Score Top Affiliating Genes
1 ovarian cystic teratoma 34.0 NKX2-1 KRT7 KRT20
2 dermoid cyst 33.9 KRT7 KRT20
3 appendix adenocarcinoma 31.4 KRT7 KRT20 CDX2
4 ovarian germ cell teratoma 31.1 NKX2-1 KRT7
5 mucinous cystadenocarcinoma 30.9 KRT7 KRT20
6 intestinal obstruction 30.8 KRT7 KRT20 CDX2
7 malignant syringoma 30.7 KRT7 KRT20
8 carcinoid syndrome 30.7 SYP ENO2
9 malignant teratoma 30.5 TP53 SYP ENO2
10 ovarian germ cell cancer 30.5 NKX2-1 KRT7
11 cystadenoma 30.4 SYP MUC6 KRT7 KRT20
12 anal squamous cell carcinoma 30.4 TP53 CDKN2A
13 ovarian mucinous adenocarcinoma 30.4 KRT7 KRT20 CDX2
14 suppressor of tumorigenicity 3 30.2 TP53 CDKN2A
15 spinal cancer 30.1 TP53 GFAP
16 papilloma of choroid plexus 30.1 TP53 SYP GFAP
17 adenosquamous carcinoma 30.1 TP53 NKX2-1 KRT7
18 adenocarcinoma in situ 30.0 KRT7 KRT20 CDX2 CDKN2A
19 endometrial adenocarcinoma 30.0 TP53 KRT7 CDKN2A
20 microcystic meningioma 30.0 GFAP ENO2
21 papillary carcinoma 29.9 NKX2-1 KRT7 KRT20
22 signet ring cell adenocarcinoma 29.9 MUC6 KRT7 KRT20 CDX2
23 ependymoma 29.9 SYP GFAP ENO2
24 ganglioneuroma 29.9 SYP GFAP ENO2
25 benign ependymoma 29.9 SYP GFAP ENO2
26 pseudomyxoma peritonei 29.8 TP53 MUC6 KRT7 KRT20 CDX2
27 mucinous adenocarcinoma 29.7 NKX2-1 KRT7 KRT20 CDX2 CDKN2A
28 hemangioma 29.7 SYP NKX2-1 ENO2
29 basal cell carcinoma 29.7 TP53 KRT7 KRT20 KRT10
30 chordoma 29.7 KRT7 GFAP CDKN2A
31 central neurocytoma 29.6 SYP GFAP ENO2
32 adenoid cystic carcinoma 29.6 TP53 KRT7 KRT20
33 granulosa cell tumor of the ovary 29.6 TP53 SYP KRT7 ENO2
34 ovarian mucinous neoplasm 29.5 SYP MUC6 KRT7 KRT20 CDX2
35 granular cell tumor 29.5 GFAP ENO2
36 atypical choroid plexus papilloma 29.5 SYP NKX2-1 KRT7
37 pleomorphic carcinoma 29.5 TP53 NKX2-1 KRT7
38 papilloma 29.4 TP53 KRT7 KRT20 KRT10 CDKN2A
39 teratoma 29.4 TP53 SYP NKX2-1 KRT7 GFAP ENO2
40 transitional cell carcinoma 29.4 TP53 KRT7 KRT20 ENO2 CDKN2A
41 carcinoid tumors, intestinal 29.3 SYP NKX2-1 ENO2
42 cervical adenocarcinoma 29.3 TP53 KRT7 KRT20 CDX2 CDKN2A
43 hydrocephalus 29.3 TP53 SYP GFAP ENO2
44 oligodendroglioma 29.1 TP53 SYP GFAP ENO2 CDKN2A
45 sweat gland cancer 29.1 TP53 SYP KRT7 KRT20 ENO2
46 central nervous system primitive neuroectodermal neoplasm 29.1 TP53 SYP GFAP ENO2
47 medulloblastoma 29.1 TP53 SYP GFAP ENO2
48 neuroendocrine tumor 29.0 SYP NKX2-1 KRT7 KRT20 ENO2
49 large cell carcinoma 28.9 SYP NKX2-1 KRT7 ENO2
50 meningioma, familial 28.8 TP53 SYP GFAP ENO2 CDKN2A

Graphical network of the top 20 diseases related to Cystic Teratoma:



Diseases related to Cystic Teratoma

Symptoms & Phenotypes for Cystic Teratoma

Drugs & Therapeutics for Cystic Teratoma

Drugs for Cystic Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Palbociclib Approved, Investigational Phase 2 571190-30-2 5330286 11431660 5005498
3
Ipilimumab Approved Phase 2 477202-00-9
4
nivolumab Approved Phase 2 946414-94-4
5 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Antibodies Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Immunoglobulins Phase 2
10 Antibodies, Monoclonal Phase 2
11 Immunologic Factors Phase 1
12
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
13 Anesthetics
14 Central Nervous System Depressants
15 Adjuvants, Immunologic
16 Carboxymethylcellulose Sodium
17 Protective Agents
18 Viscosupplements

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-Port Compared With Conventional Laparoscopic Cystectomy for Ovarian Dermoid Cysts Completed NCT02009228 Phase 3
2 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Recruiting NCT01037790 Phase 2 PD-0332991
3 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
4 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
5 Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries: Prospective Randomized Trials Unknown status NCT02580500
6 Mesial Incision for Laparoscopic Dermoid Cystectomy: a New Safe and Fertility-sparing Technique Completed NCT01590030
7 The Assessment of the Use of Anti-Adhesion Agents to Prevent Pelvic Postoperative Adhesions Recruiting NCT04063085
8 A Randomized Controlled Clinical Trial of Corneal Epithelial Autograft for Limbal Dermoid Recruiting NCT03217461
9 The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Recruiting NCT02402244
10 Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence Not yet recruiting NCT03823833

Search NIH Clinical Center for Cystic Teratoma

Genetic Tests for Cystic Teratoma

Anatomical Context for Cystic Teratoma

MalaCards organs/tissues related to Cystic Teratoma:

41
Ovary, Thyroid, Pancreas, Tongue, Testis, Bone, Brain

Publications for Cystic Teratoma

Articles related to Cystic Teratoma:

(show top 50) (show all 3742)
# Title Authors PMID Year
1
Anal duplication: is surgery indicated? A report of three cases and review of the literature. 38
31256296 2019
2
Mature ovarian cystic teratoma with "sack of marbles" appearance on magnetic resonance imaging: A case report. 38
31374057 2019
3
Intratumoral Rathke's Cleft Cyst Remnants Within Craniopharyngioma, Pituitary Adenoma, Suprasellar Dermoid, and Epidermoid Cysts: A Ubiquitous Signature of Ectodermal Lineage or a Transitional Entity? 38
30010935 2019
4
Subcutaneous dermoid cysts on the eyebrow and neck. 38
31414508 2019
5
[Treatment of benign tumors in thoracic spinal canal by modified replanting posterior ligament complex applying piezoelectric osteotomy]. 38
31407559 2019
6
[Orbital Disorders in Childhood]. 38
31412385 2019
7
Successful in vitro fertilization pregnancy and delivery after a fertility-sparing laparoscopic operation in a patient with a papillary thyroid carcinoma arising from a mature cystic teratoma. 38
31401818 2019
8
Diagnosis and Treatment of Scalp Arteriovenous Malformations With Intracranial Extension. 38
31403511 2019
9
Multilobular dermoid cyst of the orbit. 38
30215530 2019
10
Dermoid cyst simulating recurrent dacryocystitis in a toddler. 38
31358169 2019
11
Differentiation of sublingual thyroglossal duct cyst from midline dermoid cyst with diffusion weighted imaging. 38
31400658 2019
12
Mature Cystic Teratoma of Renal Pelvis: An Unusual Presentation at an Uncommon Site. 38
31258275 2019
13
Malignant Transformation of a Filum Terminale Dermoid Tumor into Adenocarcinoma. 38
30872204 2019
14
Frontosphenoidal Intraosseous Dermoid Cyst Presenting With Cicatricial Ectropion With Discharging Sinus. 38
30908467 2019
15
Endoscopic Transnasal Resection of Suprasellar Teratoma. 38
30708386 2019
16
Triple synchronous tumour of female genital tract: cervical squamous cell carcinoma, right ovarian dermoid cyst and left ovarian benign Brenner tumour. 38
31331931 2019
17
Ovarian Teratomas in Women With Anti-N-methyl-D-Aspartate Receptor Encephalitis: Topography and Composition of Immune Cell and Neuroglial Populations Is Compatible With an Autoimmune Mechanism of Disease. 38
31021857 2019
18
Unusual Imaging Findings Associated with Germ Cell Tumors. 38
31125295 2019
19
Diagnosis, management, and follow-up of extensive dermoid cyst of the submental region. 38
31372357 2019
20
[A Case of Right Frontal Dermoid Cyst with Temporal Imaging Changes in the Desease Course]. 38
31358696 2019
21
Ovarian dermoid cyst complicated by small bowel obstruction, entero-ovarian fistula formation, and malignant degeneration. 38
30878712 2019
22
Primary lacrimal gland teratoma in an adult: A clinicopathologic and radiological correlation. 38
31238481 2019
23
Frontotemporal Dermal Sinus Tract with 2 Connected Intradiploic Dermoid Cysts: A Rare Case and Review of the Literature. 38
30930322 2019
24
Trabecular carcinoid tumor arising from a mature cystic teratoma. 38
31258297 2019
25
Endometrial glial polyp and peritoneal gliomatosis: Neuropathological lesions in gynecological biopsy. 38
30900986 2019
26
Intraoperative Catastrophe during Benign Mediastinal Tumor Mass Excision: A Case Report. 38
31431846 2019
27
Carcinoid transformation of presacral dermoid cyst in patient with currarino syndrome: a case report. 38
28612626 2019
28
Retrospective evaluation of pathological results among women with ovarian endometriomas versus teratomas. 38
31086669 2019
29
Utility of the "floating ball sign" in diagnosis of ovarian cystic teratoma. 38
31360586 2019
30
Cytomorphological spectrum of scalp lesions in the population of a developing country: A retrospective study. 38
30761778 2019
31
Germ Cell Tumors of the Female Genital Tract. 38
31097117 2019
32
Extralobar pulmonary sequestration with absence of pericardium and atrial septal defect in a woman. 38
31221172 2019
33
A rare presentation of cephalad extension of an anterior mediastinal teratoma - A case report. 38
31201402 2019
34
Malignant transformation from mature cystic teratoma of the ovary. 38
31215124 2019
35
[Rapidly Growthing Mediastinal Cystic Teratoma with Suggestive Perforation by Infection in Pregnancy]. 38
31268019 2019
36
Recurrence of retroperitoneal mature cystic teratoma in an adult: A case report. 38
30976370 2019
37
The spectrum of orbital dermoid cysts and their surgical management. 38
31246146 2019
38
Diagnostic Accuracy of Midline Pediatric Neck Masses. 38
30717638 2019
39
Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts. 38
30981619 2019
40
Basal cell carcinoma masquerading as a dermoid cyst and bursitis of the knee. 38
31233571 2019
41
Anterior mediastinal teratoma with pericardial effusion. Rare presentation. 38
31086650 2019
42
Fibrin-associated diffuse large B-cell lymphoma arising in a mature cystic teratoma: A case report. 38
30977946 2019
43
Incomplete Urethral Duplication Associated with a Dermoid Cyst within a Vascular Hamartoma in a Female Dog. 38
31151175 2019
44
BRAF Wild-type, PTEN Mutant Malignant Uveal Melanoma Arising Within a Mature Ovarian Teratoma: A Case Report and Review of the Literature. 38
31157687 2019
45
A case of ovarian teratoma with nephroblastoma presenting spontaneous rupture. 38
30701637 2019
46
Emergency presentation of a dermoid cyst of the groin: a diagnostic confounder on the acute surgical take. 38
31060101 2019
47
Imaging features of unusual lesions and complications associated with ovarian mature cystic teratoma. 38
31212220 2019
48
Effects of mature cystic teratoma on reproductive health and malignant transformation: A retrospective analysis of 80 cases 38
29755032 2019
49
[Analysis of solid ovarian tumours in a Spanish paediatric population]. 38
30975583 2019
50
Evolution of epidermoid cyst into dermoid cyst: Embryological explanation and radiological-pathological correlation. 38
30604653 2019

Variations for Cystic Teratoma

Expression for Cystic Teratoma

Search GEO for disease gene expression data for Cystic Teratoma.

Pathways for Cystic Teratoma

Pathways related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SYP NKX2-1 GFAP ENO2
2
Show member pathways
10.5 TP53 CDKN2A
3 10.3 TP53 CDKN2A

GO Terms for Cystic Teratoma

Cellular components related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 KRT7 KRT20 KRT10 GFAP

Biological processes related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT7 KRT20 KRT10
2 intermediate filament organization GO:0045109 9.16 KRT20 GFAP
3 replicative senescence GO:0090399 8.96 TP53 CDKN2A
4 cornification GO:0070268 8.8 KRT7 KRT20 KRT10

Molecular functions related to Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 8.8 TP53 NKX2-1 CDX2

Sources for Cystic Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....