MCID: CYS018
MIFTS: 58

Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Cystitis

MalaCards integrated aliases for Cystitis:

Name: Cystitis 12 56 45 15 17 74 64
Infective Cystitis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1679
ICD9CM 36 595 595.9
MeSH 45 D003556
NCIt 51 C26738
SNOMED-CT 69 38822007
ICD10 34 N30 N30.9

Summaries for Cystitis

PubMed Health : 64 About cystitis: Many women know the symptoms of cystitis (a urinary tract infection, or UTI) only too well: frequent trips to the bathroom and a stinging and burning sensation when passing urine. Although these symptoms are often very unpleasant, there are effective treatments. Uncomplicated cystitis usually clears up without any problems.Unfortunately, there is no sure-fire way to reliably prevent cystitis. And a lot of the common strategies women may use in day-to-day life have not yet been scientifically tested.This article is about acute cystitis – a bladder infection often also referred to as a urinary tract infection (UTI). It is not about chronic bladder problems such as interstitial cystitis. It also doesn't include information about treating cystitis in pregnant women.

MalaCards based summary : Cystitis, also known as infective cystitis, is related to acute cystitis and interstitial cystitis. An important gene associated with Cystitis is UMOD (Uromodulin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drugs Acetylcholine and Nitrofurantoin have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and bone marrow, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A bladder disease that is characterized by inflammation of the bladder.

Wikipedia : 77 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)
# Related Disease Score Top Affiliating Genes
1 acute cystitis 34.1 CRP CXCL8 IL6 UPK1A
2 interstitial cystitis 33.1 CXCL8 EGF HBEGF IL6 KNG1 NGF
3 bladder disease 32.1 CRP HBEGF NGF TRPV1 UPK1A UPK3A
4 prostatitis 31.1 CXCL8 IL6 TNF
5 pyelitis 30.8 CRP CXCL8 IL6 TLR4
6 bacteriuria 30.7 CXCL8 IL6 TLR4 UMOD
7 pyelonephritis 30.7 CRP CXCL8 IL6 TLR4 TNF UMOD
8 acute pyelonephritis 30.6 CRP CXCL8 IL6
9 urinary tract obstruction 30.5 EGF HBEGF PTGS2 UMOD
10 vesicoureteral reflux 1 30.4 UMOD UPK1A UPK3A
11 peritonitis 30.3 CRP CXCL8 IL6 TNF
12 meningitis 30.3 CRP CXCL8 IL6 TNF
13 irritable bowel syndrome 30.2 TAC1 TNF TRPV1
14 arthritis 30.2 CXCL8 IL6 PTGS2 TNF
15 fasciitis 30.2 CXCL8 IL6 TNF
16 transitional cell carcinoma 30.2 PTGS2 UPK1A UPK3A
17 gastroenteritis 30.2 CRP CXCL8 IL6 TNF
18 ileitis 30.1 IL6 TLR4 TNF
19 purpura 30.1 CRP IL6 TNF
20 cholangitis 30.1 CRP IL6 TNF
21 colitis 30.0 CXCL8 IL6 PTGS2 TLR4 TNF
22 bronchiolitis obliterans 30.0 CXCL8 IL6 TNF
23 contact dermatitis 29.9 CXCL8 IL6 TNF
24 lyme disease 29.9 CRP IL6 TNF
25 cytomegalovirus infection 29.9 CXCL8 IL6 TNF
26 paine syndrome 29.9 NGF TAC1 TRPV1
27 somatoform disorder 29.8 NGF TAC1 TRPV1
28 end stage renal failure 29.8 CRP IL6 TNF UMOD
29 pharyngitis 29.8 CRP CXCL8 PTGS2
30 sleep apnea 29.8 CRP CXCL8 IL6 TNF
31 peptic ulcer disease 29.8 CXCL8 PTGS2 TNF
32 pneumonia 29.7 CRP CXCL8 IL6 TLR4 TNF
33 adenomyosis 29.7 NGF PTGS2 TRPV1
34 ulcerative colitis 29.7 CRP CXCL8 IL6 TLR4 TNF
35 bacterial vaginosis 29.7 CXCL8 IL6 TLR4 TNF
36 myeloma, multiple 29.7 CRP CXCL8 IL6 TNF
37 rheumatoid arthritis 29.6 CRP CXCL8 IL6 PTGS2 TLR4 TNF
38 chronic kidney failure 29.6 CRP IL6 PTGS2 UMOD
39 esophagitis 29.6 CXCL8 IL6 PTGS2 TRPV1
40 acute pancreatitis 29.6 CRP CXCL8 IL6
41 pulmonary disease, chronic obstructive 29.5 CRP CXCL8 IL6 TNF TRPV1
42 pertussis 29.5 IL6 TLR4 TNF
43 chlamydia 29.5 CRP CXCL8 IL6 TLR4 TNF
44 bronchiolitis 29.5 CRP CXCL8 IL6 TLR4 TNF
45 inflammatory bowel disease 29.5 CRP CXCL8 IL6 TLR4 TNF
46 asthma 29.4 CXCL8 IL6 KNG1 NGF TAC1 TNF
47 hemorrhagic cystitis 12.6
48 chronic interstitial cystitis 12.5
49 acute gonococcal cystitis 12.5
50 eosinophilic cystitis 12.5

Comorbidity relations with Cystitis via Phenotypic Disease Network (PDN): (show all 32)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bladder Cancer Bladder Neck Obstruction
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Neurogenic Bladder Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Prostatic Hypertrophy Protein-Energy Malnutrition
Pyelonephritis Radiation Cystitis
Schizophreniform Disorder Transient Cerebral Ischemia
Urethral Stricture Urethritis

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to Cystitis

Symptoms & Phenotypes for Cystitis

MGI Mouse Phenotypes related to Cystitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 HBEGF IL6 NGF P2RX3 PTGS2 TAC1
2 cardiovascular system MP:0005385 10.06 CRP HBEGF IL6 NGF P2RX3 PTGS2
3 homeostasis/metabolism MP:0005376 10.03 CRP HBEGF IL6 NGF P2RX3 PTGS2
4 integument MP:0010771 9.97 CKAP4 EGF HBEGF IL6 NGF P2RX3
5 renal/urinary system MP:0005367 9.56 FZD8 IL6 PTGS2 TAC1 TLR4 TRPV1
6 respiratory system MP:0005388 9.17 HBEGF IL6 P2RX3 PTGS2 TACR1 TLR4

Drugs & Therapeutics for Cystitis

PubMedHealth treatment related to Cystitis: 64

For many women, cystitis is a one-time unpleasant problem. In others, it may keep coming back. Antibiotics have been proven to effectively relieve acute cystitis, and they usually work quickly. There are also some home remedies that may help, like drinking plenty of fluids or applying heat. Herbal products are available too.

Drugs for Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 337)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 51-84-3 187
2
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 67-20-9 5353830
3
Methenamine Approved, Vet_approved Phase 4,Not Applicable 100-97-0 4101
4
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
5
Cephalexin Approved, Investigational, Vet_approved Phase 4,Not Applicable 15686-71-2 27447
6
Sulfamethoxazole Approved Phase 4,Phase 3,Not Applicable 723-46-6 5329
7
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Not Applicable 738-70-5 5578
8
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
10
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
11
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
14
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
15
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Not Applicable 85721-33-1 2764
16
Morphine Approved, Investigational Phase 4 57-27-2 5288826
17
Belladonna Approved, Experimental Phase 4
18
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
19
Cycloserine Approved Phase 4 68-41-7 401 6234
20
Doripenem Approved, Investigational Phase 4 148016-81-3 73303
21
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Not Applicable 9004-61-9 53477741
22
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
23
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
24
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
25
Sodium Citrate Approved, Investigational Phase 4,Not Applicable 68-04-2
26
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
27
Methylene blue Approved, Investigational Phase 4 61-73-4
28
Metronidazole Approved Phase 4 443-48-1 4173
29
Fosfomycin Approved Phase 4,Not Applicable 23155-02-4 446987
30
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
31
Piroxicam Approved, Investigational Phase 4 36322-90-4 5280452 54676228
32
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
33
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
34
Cefoxitin Approved Phase 4 35607-66-0 441199
35
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
36
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
37
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
39
BCG vaccine Investigational Phase 4,Phase 2
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Gentamicins Phase 4,Phase 2
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Botulinum Toxins, Type A Phase 4,Phase 2,Phase 1,Early Phase 1
45 Acetylcholine Release Inhibitors Phase 4,Phase 2,Phase 1,Early Phase 1
46 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Botulinum Toxins Phase 4,Phase 2,Phase 1,Early Phase 1
49 abobotulinumtoxinA Phase 4,Phase 2,Phase 1,Early Phase 1
50 Neuromuscular Agents Phase 4,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 294)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Gentamicin Bladder Instillation Trial Unknown status NCT01884467 Phase 4 Gentamicin;Placebo
3 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
4 Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
5 Efficacy of Oxybutynin in Paediatric Cystitis Completed NCT03877289 Phase 4 Oxybutynin
6 Intravesicular Onabotulinumtoxin A in Interstitial Cystitis Completed NCT02297100 Phase 4 Onabotulinumtoxin A
7 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
8 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
9 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
10 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
11 Botox as a Treatment for Interstitial Cystitis in Women Completed NCT00194610 Phase 4 Botox
12 A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department Completed NCT01749605 Phase 4 Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days;ciprofloxacin 250 mg BID x 3 days
13 Management of Urinary Tract Infections in Primary Care Facilities. Completed NCT01132131 Phase 4
14 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
15 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
16 A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections Completed NCT00965848 Phase 4 Doripenem
17 Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery Completed NCT00488904 Phase 4
18 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
19 Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis Recruiting NCT03379389 Phase 4 Methenamine + Methylthioninium;Methenamine + Methylthioninium + Acriflavine + Atropa belladona;Antibiotics
20 Management of Sub-Clinical Bacteriuria in Pregnancy Recruiting NCT03275623 Phase 4 Antibiotic
21 Antibiotic Prophylaxis Before Shock Wave Lithotripsy Recruiting NCT03692715 Phase 4 Ciprofloxacin;Placebo
22 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
23 Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate Recruiting NCT03633643 Phase 4 oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets);oral applications of Placebo
24 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
25 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
26 Efficacy of IARULIL® in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract Active, not recruiting NCT02366676 Phase 4 hyaluronic acid and chondroitin sulphate
27 Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women Active, not recruiting NCT01966653 Phase 4 nitrofurantoin;fosfomycin
28 Solifenacin, Levofloxacin or Lornoxicam, Which Is Ideal for Management of Intravesical Instillation BCG Side Effects? Active, not recruiting NCT03038321 Phase 4 sofenacin;Tavanic;Xefo
29 Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT03218852 Phase 4 prednisone and cyclophosphamide;prednisone alone
30 Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
31 Effectiveness and Safety Study of Pentosan Polysulfate Sodium for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
32 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
33 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
34 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
35 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
36 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
37 Nitrofurantoin Macrocrystals 3 Days Versus 7 Days in the Treatment of Women With Uncomplicated Cystitis Withdrawn NCT00361998 Phase 4 NITROFURANTOIN MACROCRYSTALS
38 Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms Unknown status NCT00094874 Phase 3
39 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
40 Efficacy Study of Adalimumab to Treat Interstitial Cystitis Completed NCT01295814 Phase 3 Adalimumab
41 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
42 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Completed NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen
43 Omalizumab in Interstitial Cystitis/Bladder Pain Syndrome Completed NCT01294878 Phase 3 omalizumab
44 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
45 Efficacy and Safety of Cefditoren Pivoxil Versus Ciprofloxacin in Acute Uncomplicated Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
46 Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS) Completed NCT00124306 Phase 3 Amitriptyline
47 A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression Completed NCT02497287 Phase 3 Esketamine (Intranasal Spray);Duloxetine (Oral Antidepressant);Escitalopram (Oral Antidepressant);Sertraline (Oral Antidepressant);Venlafaxine Extended Release (XR) (Oral Antidepressant)
48 D Mannose in Recurrent Urinary Tract Infections Completed NCT01808755 Phase 3 trimethoprim/sulfamethoxazole
49 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
50 Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001) Completed NCT02137772 Phase 3 Letermovir;Placebo

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: cystitis

Genetic Tests for Cystitis

Anatomical Context for Cystitis

MalaCards organs/tissues related to Cystitis:

42
Prostate, Bone, Bone Marrow, Kidney, Testes, Spinal Cord, Liver

Publications for Cystitis

Articles related to Cystitis:

(show top 50) (show all 4016)
# Title Authors Year
1
What can we learn by examining variations in the use of urine culture in the management of acute cystitis? A retrospective cohort study with linked administrative data in British Columbia, Canada, 2005-2011. ( 30849104 )
2019
2
A systematic review of preventive and therapeutic options for symptoms of cystitis in patients with bladder cancer receiving intravesical bacillus Calmette-Guérin immunotherapy. ( 30870228 )
2019
3
Guidelines for patients with acute uncomplicated cystitis may not be a paper tiger: a call for its implementation in clinical routine. ( 30564871 )
2019
4
Is BK Virus-Associated Cystitis a Generalized Epithelial Disease? ( 30605908 )
2019
5
Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression. ( 30609029 )
2019
6
Emphysematous cystitis. ( 30624190 )
2019
7
Editorial Comment on: Endoscopic Intravesical Fibrin Glue Application in the Treatment of Refractory Hemorrhagic Radiation Cystitis: A Single Cohort Pilot Study by Bove et al. (From: Bove P, Iacovelli V, Tirindelli MC, et al. J Endourol 2019;33:93-98; DOI: 10.1089/end.2018.0028). ( 30632409 )
2019
8
Encrusted cystitis detected by 18F-FDG PET/CT. ( 30638879 )
2019
9
Re: An Evaluation of the Pharmacotherapy for Interstitial Cystitis. ( 30664596 )
2019
10
Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis. ( 30671141 )
2019
11
Intravesical Administration of Xenogeneic Porcine Urothelial Cells Attenuates Cyclophosphamide-Induced Cystitis in Mice. ( 30675801 )
2019
12
Management of symptom flares and patient-reported flare triggers in interstitial cystitis/ bladder pain syndrome (IC/BPS) - Findings from one site of the MAPP Research Network. ( 30682464 )
2019
13
Comparison of Voiding Dysfunction Phenotypes in Women with Interstitial Cystitis/Bladder Pain and Myofascial Pelvic Pain: Results from the ICEPAC Trial. ( 30682465 )
2019
14
Iron Chelation as Novel Treatment for Interstitial Cystitis. ( 30695781 )
2019
15
Recurrent Abdominal Pain in Systemic Lupus Erythematosus: Concurrent Lupus Enteritis and Lupus Cystitis. ( 30710539 )
2019
16
BK Virus Associated Haemorrhagic Cystitis. A Systematic review of current prevention and treatment strategies. ( 30711618 )
2019
17
Green tea as an adjunctive therapy for treatment of acute uncomplicated cystitis in women: A randomized clinical trial. ( 30712716 )
2019
18
Canadian Urological Association Best Practice Report: Diagnosis and management of radiation-induced hemorrhagic cystitis. ( 30721124 )
2019
19
IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways. ( 30733505 )
2019
20
Critical role of mismatched HLA in hemorrhagic cystitis after haploidentical hematopoietic stem cell transplant. ( 30735721 )
2019
21
Cystitis Cystica on Routine Cystoscopy at Time of Total Laparoscopic Hysterectomy. ( 30735732 )
2019
22
Re: Digital Quantitative Analysis of Mast Cell Infiltration in Interstitial Cystitis. ( 30759680 )
2019
23
Virulence factors and antimicrobial resistance in uropathogenic Escherichiacoli strains isolated from cystitis and pyelonephritis ( 30761847 )
2019
24
In premenopausal women with recurrent cystitis, increasing water intake for 12 months reduced recurrence. ( 30776805 )
2019
25
IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis. ( 30785353 )
2019
26
Urine Culture and Uncomplicated Cystitis: A Bigger Picture? ( 30797295 )
2019
27
Urine Culture and Uncomplicated Cystitis: The Minuses Outweigh the Pluses. ( 30797296 )
2019
28
Efficacy of pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome: results of a systematic review of randomized controlled trials. ( 30849922 )
2019
29
Pharmacokinetics, Safety, and Clinical Outcomes of Omadacycline in Women with Cystitis: Results from a Phase 1 Study. ( 30858208 )
2019
30
Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation. ( 30863309 )
2019
31
Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies. ( 30865573 )
2019
32
Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice. ( 30874926 )
2019
33
Uroprotective effect of ambroxol in cyclophosphamide-induced cystitis in mice. ( 30895504 )
2019
34
Antimicrobial resistance patterns in urinary E. coli isolates after a change in a single center's guidelines for uncomplicated cystitis in ambulatory settings. ( 30895921 )
2019
35
Emphysematous cystitis in an elderly Japanese patient with type 2 diabetes mellitus. ( 30899503 )
2019
36
Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis. ( 30905425 )
2019
37
Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus. ( 30905628 )
2019
38
Clustering of Patients with Interstitial Cystitis/Bladder Pain Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome. ( 30916629 )
2019
39
Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review. ( 30015351 )
2019
40
A rare x-ray image of emphysematous cystitis. ( 30406017 )
2019
41
Photoselective Vaporisation of the Bladder for the Management of Radiation Cystitis - Technique and Initial Outcomes. ( 29777786 )
2018
42
Struvite urolithiasis with eosinophilic polypoid cystitis in a shih tzu dog. ( 29386681 )
2018
43
Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis. ( 29654564 )
2018
44
Prevention of Cystitis: Travelling between the Imaginary and Reality. ( 29925071 )
2018
45
Downregulation of tight junction protein zonula occludens-2 and urothelium damage in a cyclophosphamide-induced mouse model of cystitis. ( 29880173 )
2018
46
BK Viremia as a Predictor of Hemorrhagic Cystitis in Adults During the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplantation. ( 29880378 )
2018
47
Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire. A useful tool for the diagnosis of bladder pain syndrome. ( 29650471 )
2018
48
Safety and Feasibility of Intravesical Instillation of Botulinum Toxin-A in Hydrogel-based Slow-release Delivery System in Patients With Interstitial Cystitis-Bladder Pain Syndrome: A Pilot Study. ( 29307733 )
2018
49
Alleviation of Cyclophosphamide-induced Hemorrhagic Cystitis by Dietary Pomegranate: A Comparative Experimental Study With Mesna. ( 29734214 )
2018
50
Severe BK polyomavirus-induced hemorrhagic cystitis in a kidney transplant recipient with the absence of renal allograft involvement. ( 29143415 )
2018

Variations for Cystitis

Expression for Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for Cystitis

Pathways related to Cystitis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 EGF FZD8 IL6 NGF PTGS2 TLR4
2 12.79 CXCL8 EGF FZD8 IL6 PTGS2
3
Show member pathways
12.65 EGF IL6 NGF TLR4 TNF
4
Show member pathways
12.55 CXCL8 IL6 TACR1 TLR4 TNF
5
Show member pathways
12.29 CRP IL6 PTGS2 TNF
6
Show member pathways
12.28 CXCL8 IL6 PTGS2 TNF
7 12.25 FZD8 HBEGF TLR4 TNF
8
Show member pathways
12.25 CXCL8 IL6 PTGS2 TLR4 TNF
9
Show member pathways
12.21 CXCL8 IL6 TLR4 TNF
10
Show member pathways
12.2 CXCL8 HBEGF IL6 NGF TNF
11
Show member pathways
12.17 CXCL8 IL6 PTGS2 TNF
12
Show member pathways
12.12 CXCL8 IL6 TLR4 TNF
13
Show member pathways
12.05 EGF FZD8 HBEGF IL6
14 11.95 EGF FZD8 IL6 PTGS2 TLR4 TNF
15 11.93 CXCL8 IL6 PTGS2 TNF
16 11.85 CXCL8 IL6 NGF TAC1 TACR1 TNF
17 11.83 CXCL8 IL6 TLR4 TNF
18
Show member pathways
11.82 CXCL8 IL6 TLR4
19 11.82 CXCL8 PTGS2 TLR4 TNF
20 11.78 CXCL8 IL6 TLR4
21 11.78 CXCL8 IL6 TLR4 TNF
22
Show member pathways
11.72 CXCL8 PTGS2 TNF
23 11.69 IL6 PTGS2 TNF
24 11.68 CXCL8 IL6 TLR4 TNF
25 11.64 CXCL8 HBEGF IL6
26 11.64 CXCL8 EGF HBEGF UPK3A
27 11.56 CXCL8 EGF IL6 TNF
28
Show member pathways
11.53 CXCL8 IL6 PTGS2 TNF
29 11.51 CXCL8 IL6 PTGS2 TACR1 TLR4 TNF
30 11.5 CXCL8 IL6 PTGS2
31 11.49 HBEGF IL6 TNF
32 11.46 IL6 KNG1 TNF
33 11.45 CXCL8 IL6 TLR4 TNF
34 11.36 CXCL8 IL6 PTGS2 TNF
35 11.31 CXCL8 IL6 TLR4 TNF
36 11.3 IL6 TLR4 TNF
37 10.98 CXCL8 EGF IL6 NGF TNF
38 10.48 TAC1 TACR1
39 10.3 CRP CXCL8 IL6 PTGS2 TNF

GO Terms for Cystitis

Cellular components related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.87 HBEGF P2RX3 TACR1 TLR4 TNF TRPV1
2 extracellular space GO:0005615 9.81 CRP CXCL8 EGF HBEGF IL6 KNG1
3 extracellular region GO:0005576 9.65 CRP CXCL8 EGF HBEGF IL6 KNG1
4 apical plasma membrane urothelial plaque GO:0120001 8.62 UPK1A UPK3A
5 plasma membrane GO:0005886 10.07 CKAP4 EGF FZD8 HBEGF KNG1 P2RX3

Biological processes related to Cystitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 CXCL8 IL6 NGF PTGS2 UMOD
2 angiogenesis GO:0001525 9.93 CXCL8 EGF FZD8 PTGS2
3 positive regulation of gene expression GO:0010628 9.93 CRP EGF IL6 NGF TLR4 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.84 CXCL8 IL6 TLR4 TNF
5 response to organic substance GO:0010033 9.83 P2RX3 PTGS2 TNF
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.82 EGF HBEGF IL6
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 IL6 PTGS2 TNF
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 KNG1 TAC1 TACR1 TRPV1
9 positive regulation of apoptotic process GO:0043065 9.8 IL6 KNG1 NGF PTGS2 TNF TRPV1
10 regulation of inflammatory response GO:0050727 9.78 PTGS2 TLR4 TNF
11 response to glucocorticoid GO:0051384 9.77 IL6 PTGS2 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.74 IL6 TLR4 TNF
13 sensory perception of pain GO:0019233 9.73 PTGS2 TAC1 TRPV1
14 positive regulation of acute inflammatory response GO:0002675 9.64 IL6 TAC1
15 behavioral response to pain GO:0048266 9.63 P2RX3 TRPV1
16 negative regulation of blood vessel diameter GO:0097756 9.62 CRP PTGS2
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.62 TLR4 TNF
18 positive regulation of lymphocyte proliferation GO:0050671 9.61 TAC1 TLR4
19 positive regulation of chemokine production GO:0032722 9.61 IL6 TLR4 TNF
20 tachykinin receptor signaling pathway GO:0007217 9.58 TAC1 TACR1
21 response to pain GO:0048265 9.58 TAC1 TACR1 TRPV1
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.56 HBEGF IL6 PTGS2 TNF
23 positive regulation of neuroinflammatory response GO:0150078 9.55 IL6 TNF
24 cellular response to ATP GO:0071318 9.54 P2RX3 PTGS2 TRPV1
25 positive regulation of fever generation GO:0031622 9.52 PTGS2 TNF
26 urinary bladder smooth muscle contraction GO:0014832 9.51 P2RX3 TRPV1
27 detection of abiotic stimulus GO:0009582 9.48 TAC1 TACR1
28 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
29 inflammatory response GO:0006954 9.32 CRP CXCL8 IL6 KNG1 PTGS2 TAC1
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 PTGS2 TLR4 TNF TRPV1
31 regulation of signaling receptor activity GO:0010469 10 CXCL8 HBEGF IL6 NGF TNF

Molecular functions related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.26 FZD8 KNG1 NGF TLR4
2 growth factor activity GO:0008083 8.92 EGF HBEGF IL6 NGF

Sources for Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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