MCID: CYS018
MIFTS: 58

Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Cystitis

MalaCards integrated aliases for Cystitis:

Name: Cystitis 12 56 45 15 64 17 74
Infective Cystitis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1679
ICD9CM 36 595 595.9
MeSH 45 D003556
NCIt 51 C26738
SNOMED-CT 69 38822007
ICD10 34 N30 N30.9

Summaries for Cystitis

PubMed Health : 64 About cystitis: Many women know the symptoms of cystitis (a urinary tract infection, or UTI) only too well: frequent trips to the bathroom and a stinging and burning sensation when passing urine. Although these symptoms are often very unpleasant, there are effective treatments. Uncomplicated cystitis usually clears up without any problems.Unfortunately, there is no sure-fire way to reliably prevent cystitis. And a lot of the common strategies women may use in day-to-day life have not yet been scientifically tested.This article is about acute cystitis – a bladder infection often also referred to as a urinary tract infection (UTI). It is not about chronic bladder problems such as interstitial cystitis. It also doesn't include information about treating cystitis in pregnant women.

MalaCards based summary : Cystitis, also known as infective cystitis, is related to acute cystitis and interstitial cystitis. An important gene associated with Cystitis is UMOD (Uromodulin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drugs Nitrofurantoin and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and bone marrow, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A bladder disease that is characterized by inflammation of the bladder.

Wikipedia : 77 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
# Related Disease Score Top Affiliating Genes
1 acute cystitis 34.1 CRP CXCL8 IL6 UPK1A
2 interstitial cystitis 33.1 CXCL8 EGF HBEGF IL6 KNG1 NGF
3 bladder disease 32.2 CRP HBEGF NGF TRPV1 UPK1A UPK3A
4 prostatitis 31.1 CXCL8 IL6 TNF
5 pyelitis 30.8 CRP CXCL8 IL6 TLR4
6 bacteriuria 30.8 CXCL8 IL6 TLR4 UMOD
7 pyelonephritis 30.7 CRP CXCL8 IL6 TLR4 TNF UMOD
8 acute pyelonephritis 30.7 CRP CXCL8 IL6
9 urinary tract obstruction 30.5 EGF HBEGF PTGS2 UMOD
10 vesicoureteral reflux 1 30.4 UMOD UPK1A UPK3A
11 peritonitis 30.4 CRP CXCL8 IL6 TNF
12 meningitis 30.3 CRP CXCL8 IL6 TNF
13 irritable bowel syndrome 30.3 TAC1 TNF TRPV1
14 arthritis 30.3 CXCL8 IL6 PTGS2 TNF
15 fasciitis 30.2 CXCL8 IL6 TNF
16 transitional cell carcinoma 30.2 PTGS2 UPK1A UPK3A
17 gastroenteritis 30.2 CRP CXCL8 IL6 TNF
18 ileitis 30.1 IL6 TLR4 TNF
19 purpura 30.1 CRP IL6 TNF
20 cholangitis 30.1 CRP IL6 TNF
21 colitis 30.0 CXCL8 IL6 PTGS2 TLR4 TNF
22 bronchiolitis obliterans 30.0 CXCL8 IL6 TNF
23 contact dermatitis 29.9 CXCL8 IL6 TNF
24 lyme disease 29.9 CRP IL6 TNF
25 cytomegalovirus infection 29.9 CXCL8 IL6 TNF
26 paine syndrome 29.9 NGF TAC1 TRPV1
27 somatoform disorder 29.9 NGF TAC1 TRPV1
28 end stage renal failure 29.9 CRP IL6 TNF UMOD
29 pharyngitis 29.9 CRP CXCL8 PTGS2
30 sleep apnea 29.8 CRP CXCL8 IL6 TNF
31 peptic ulcer disease 29.8 CXCL8 PTGS2 TNF
32 pneumonia 29.8 CRP CXCL8 IL6 TLR4 TNF
33 adenomyosis 29.7 NGF PTGS2 TRPV1
34 ulcerative colitis 29.7 CRP CXCL8 IL6 TLR4 TNF
35 bacterial vaginosis 29.7 CXCL8 IL6 TLR4 TNF
36 myeloma, multiple 29.7 CRP CXCL8 IL6 TNF
37 rheumatoid arthritis 29.7 CRP CXCL8 IL6 PTGS2 TLR4 TNF
38 chronic kidney failure 29.7 CRP IL6 PTGS2 UMOD
39 esophagitis 29.6 CXCL8 IL6 PTGS2 TRPV1
40 acute pancreatitis 29.6 CRP CXCL8 IL6
41 pulmonary disease, chronic obstructive 29.5 CRP CXCL8 IL6 TNF TRPV1
42 pertussis 29.5 IL6 TLR4 TNF
43 chlamydia 29.5 CRP CXCL8 IL6 TLR4 TNF
44 bronchiolitis 29.5 CRP CXCL8 IL6 TLR4 TNF
45 inflammatory bowel disease 29.5 CRP CXCL8 IL6 TLR4 TNF
46 asthma 29.4 CXCL8 IL6 KNG1 NGF TAC1 TNF
47 hemorrhagic cystitis 12.6
48 chronic interstitial cystitis 12.6
49 glandular cystitis 12.6
50 acute gonococcal cystitis 12.5

Comorbidity relations with Cystitis via Phenotypic Disease Network (PDN): (show all 32)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bladder Cancer Bladder Neck Obstruction
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Neurogenic Bladder Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Prostatic Hypertrophy Protein-Energy Malnutrition
Pyelonephritis Radiation Cystitis
Schizophreniform Disorder Transient Cerebral Ischemia
Urethral Stricture Urethritis

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to Cystitis

Symptoms & Phenotypes for Cystitis

MGI Mouse Phenotypes related to Cystitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 HBEGF IL6 NGF P2RX3 PTGS2 TAC1
2 cardiovascular system MP:0005385 10.06 CRP HBEGF IL6 NGF P2RX3 PTGS2
3 homeostasis/metabolism MP:0005376 10.03 CRP HBEGF IL6 NGF P2RX3 PTGS2
4 integument MP:0010771 9.97 CKAP4 EGF HBEGF IL6 NGF P2RX3
5 renal/urinary system MP:0005367 9.56 FZD8 IL6 PTGS2 TAC1 TLR4 TRPV1
6 respiratory system MP:0005388 9.17 HBEGF IL6 P2RX3 PTGS2 TACR1 TLR4

Drugs & Therapeutics for Cystitis

PubMedHealth treatment related to Cystitis: 64

For many women, cystitis is a one-time unpleasant problem. In others, it may keep coming back. Antibiotics have been proven to effectively relieve acute cystitis, and they usually work quickly. There are also some home remedies that may help, like drinking plenty of fluids or applying heat. Herbal products are available too.

Drugs for Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 339)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 67-20-9 5353830
2
Fosfomycin Approved Phase 4,Not Applicable 23155-02-4 446987
3
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 51-84-3 187
4
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Not Applicable 85721-33-1 2764
5
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5479529 5361202
6
Metronidazole Approved Phase 4 443-48-1 4173
7
Methenamine Approved, Vet_approved Phase 4,Not Applicable 100-97-0 4101
8
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
9
Cephalexin Approved, Investigational, Vet_approved Phase 4,Not Applicable 15686-71-2 27447
10
Sulfamethoxazole Approved Phase 4,Phase 3,Not Applicable 723-46-6 5329
11
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Not Applicable 738-70-5 5578
12
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
13
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
14
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
15
Ibuprofen Approved Phase 4 15687-27-1 3672
16
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
17
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
18
Morphine Approved, Investigational Phase 4 57-27-2 5288826
19
Belladonna Approved, Experimental Phase 4
20
Cycloserine Approved Phase 4 68-41-7 6234 401
21
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
22
Doripenem Approved, Investigational Phase 4 148016-81-3 73303
23
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Not Applicable 9004-61-9 53477741
24
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
25
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
26
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
27
Sodium Citrate Approved, Investigational Phase 4,Not Applicable 68-04-2
28
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
29
Methylene blue Approved, Investigational Phase 4 61-73-4
30
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
31
Piroxicam Approved, Investigational Phase 4 36322-90-4 54676228 5280452
32
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
33
Cefoxitin Approved Phase 4 35607-66-0 441199
34
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
35
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
36
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
37
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
39
BCG vaccine Investigational Phase 4,Phase 2
40 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Anti-Infective Agents, Urinary Phase 4,Phase 3,Phase 2,Not Applicable
43 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Renal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Gentamicins Phase 4,Phase 2
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Acetylcholine Release Inhibitors Phase 4,Phase 2,Phase 1,Early Phase 1
49 Botulinum Toxins Phase 4,Phase 2,Phase 1,Early Phase 1
50 Botulinum Toxins, Type A Phase 4,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 296)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women Unknown status NCT01966653 Phase 4 nitrofurantoin;fosfomycin
3 Gentamicin Bladder Instillation Trial Unknown status NCT01884467 Phase 4 Gentamicin;Placebo
4 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
5 Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
6 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Unknown status NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
7 Efficacy of Oxybutynin in Paediatric Cystitis Completed NCT03877289 Phase 4 Oxybutynin
8 Intravesicular Onabotulinumtoxin A in Interstitial Cystitis Completed NCT02297100 Phase 4 Onabotulinumtoxin A
9 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
10 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
11 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
12 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
13 Botox as a Treatment for Interstitial Cystitis in Women Completed NCT00194610 Phase 4 Botox
14 A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department Completed NCT01749605 Phase 4 Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days;ciprofloxacin 250 mg BID x 3 days
15 Management of Urinary Tract Infections in Primary Care Facilities. Completed NCT01132131 Phase 4
16 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
17 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
18 A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections Completed NCT00965848 Phase 4 Doripenem
19 Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery Completed NCT00488904 Phase 4
20 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
21 Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis Recruiting NCT03379389 Phase 4 Methenamine + Methylthioninium;Methenamine + Methylthioninium + Acriflavine + Atropa belladona;Antibiotics
22 Management of Sub-Clinical Bacteriuria in Pregnancy Recruiting NCT03275623 Phase 4 Antibiotic
23 Antibiotic Prophylaxis Before Shock Wave Lithotripsy Recruiting NCT03692715 Phase 4 Ciprofloxacin;Placebo
24 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
25 Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate Recruiting NCT03633643 Phase 4 oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets);oral applications of Placebo
26 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
27 Efficacy of IARULIL® in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract Active, not recruiting NCT02366676 Phase 4 hyaluronic acid and chondroitin sulphate
28 Solifenacin, Levofloxacin or Lornoxicam, Which Is Ideal for Management of Intravesical Instillation BCG Side Effects? Active, not recruiting NCT03038321 Phase 4 sofenacin;Tavanic;Xefo
29 Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT03218852 Phase 4 prednisone and cyclophosphamide;prednisone alone
30 Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
31 Effectiveness and Safety Study of Pentosan Polysulfate Sodium for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
32 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
33 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
34 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
35 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
36 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
37 Nitrofurantoin Macrocrystals 3 Days Versus 7 Days in the Treatment of Women With Uncomplicated Cystitis Withdrawn NCT00361998 Phase 4 NITROFURANTOIN MACROCRYSTALS
38 Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms Unknown status NCT00094874 Phase 3
39 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
40 Efficacy Study of Adalimumab to Treat Interstitial Cystitis Completed NCT01295814 Phase 3 Adalimumab
41 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
42 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Completed NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen
43 Omalizumab in Interstitial Cystitis/Bladder Pain Syndrome Completed NCT01294878 Phase 3 omalizumab
44 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
45 Efficacy and Safety of Cefditoren Pivoxil Versus Ciprofloxacin in Acute Uncomplicated Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
46 Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS) Completed NCT00124306 Phase 3 Amitriptyline
47 D Mannose in Recurrent Urinary Tract Infections Completed NCT01808755 Phase 3 trimethoprim/sulfamethoxazole
48 A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression Completed NCT02497287 Phase 3 Esketamine (Intranasal Spray);Duloxetine (Oral Antidepressant);Escitalopram (Oral Antidepressant);Sertraline (Oral Antidepressant);Venlafaxine Extended Release (XR) (Oral Antidepressant)
49 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
50 Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001) Completed NCT02137772 Phase 3 Letermovir;Placebo

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: cystitis

Genetic Tests for Cystitis

Anatomical Context for Cystitis

MalaCards organs/tissues related to Cystitis:

42
Prostate, Bone, Bone Marrow, Kidney, Testes, Spinal Cord, Liver

Publications for Cystitis

Articles related to Cystitis:

(show top 50) (show all 4041)
# Title Authors Year
1
What can we learn by examining variations in the use of urine culture in the management of acute cystitis? A retrospective cohort study with linked administrative data in British Columbia, Canada, 2005-2011. ( 30849104 )
2019
2
The use of nitrofurantoin for children with acute cystitis caused by extended-spectrum Β-lactamase-producing Escherichia coli. ( 31014984 )
2019
3
Anxiety severity does not influence treatment outcomes in patients with interstitial cystitis/bladder pain syndrome. ( 31059599 )
2019
4
A systematic review of preventive and therapeutic options for symptoms of cystitis in patients with bladder cancer receiving intravesical bacillus Calmette-Guérin immunotherapy. ( 30870228 )
2019
5
Severe Hemorrhagic Cystitis Caused by Cyclophosphamide and Capecitabine Therapy in Breast Cancer Patients: Two Case Reports and Literature Review. ( 31043944 )
2019
6
Machine Learning Approach to find the relation between Endometriosis, benign breast disease, cystitis and non-toxic goiter. ( 30932000 )
2019
7
Urine Culture and Uncomplicated Cystitis: The Minuses Outweigh the Pluses. ( 30797296 )
2019
8
Efficacy of pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome: results of a systematic review of randomized controlled trials. ( 30849922 )
2019
9
Pharmacokinetics, Safety, and Clinical Outcomes of Omadacycline in Women with Cystitis: Results from a Phase 1b Study. ( 30858208 )
2019
10
Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation. ( 30863309 )
2019
11
Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies. ( 30865573 )
2019
12
Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice. ( 30874926 )
2019
13
Uroprotective effect of ambroxol in cyclophosphamide-induced cystitis in mice. ( 30895504 )
2019
14
Antimicrobial resistance patterns in urinary E. coli isolates after a change in a single center's guidelines for uncomplicated cystitis in ambulatory settings. ( 30895921 )
2019
15
Emphysematous cystitis in an elderly Japanese patient with type 2 diabetes mellitus. ( 30899503 )
2019
16
Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis. ( 30905425 )
2019
17
Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus. ( 30905628 )
2019
18
Clustering of Patients with Interstitial Cystitis/Bladder Pain Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome. ( 30916629 )
2019
19
A Culture-Independent Analysis of the Microbiota of Female Interstitial Cystitis/Bladder Pain Syndrome Participants in the MAPP Research Network. ( 30917614 )
2019
20
Risk Factors for Interstitial Cystitis in the General Population and in Individuals With Depression. ( 30943693 )
2019
21
Patterns and predictors of Hunner lesion recurrence in patients with interstitial cystitis. ( 30945347 )
2019
22
Re: Therapeutic Effects of Endoscopic Ablation in Patients with Hunner Type Interstitial Cystitis. ( 30958746 )
2019
23
Re: The Efficacy of Botulinum Toxin A and Sacral Neuromodulation in the Management of Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS), What do we Know? ICI-RS 2017 Think Tank, Bristol. ( 30958748 )
2019
24
Single nucleotide polymorphism analysis in interstitial cystitis/painful bladder syndrome. ( 30973927 )
2019
25
Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis. ( 30989724 )
2019
26
Functional effects of blocking VEGF/VEGFR2 signaling in the rat urinary bladder in acute and chronic CYP-induced cystitis. ( 30995112 )
2019
27
UCA1 promotes cell viability, proliferation and migration potential through UCA1/miR-204/CCND2 pathway in primary cystitis glandularis cells. ( 30999112 )
2019
28
Evaluation of the draft guidelines proposed by EMA and FDA for the clinical diagnosis of acute uncomplicated cystitis in women. ( 31004204 )
2019
29
Safety analysis of long-term phenazopyridine use for radiation cystitis. ( 31006341 )
2019
30
The Vaginal and Urinary Microbiomes in Premenopausal Women With Interstitial Cystitis/Bladder Pain Syndrome as Compared to Unaffected Controls: A Pilot Cross-Sectional Study. ( 31024861 )
2019
31
Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS). ( 31028455 )
2019
32
Cystitis and Pyelonephritis: Diagnosis, Treatment, and Prevention. ( 31030820 )
2019
33
Retraction: An Overview of the Pathology and Emerging Treatment Approaches for Interstitial Cystitis/Bladder Pain Syndrome. ( 31032161 )
2019
34
The severity and distribution of non-urologic pain and urogenital pain in overactive bladder are intermediate between interstitial cystitis and controls. ( 31034917 )
2019
35
Antibiotic sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not Ready for Primetime. ( 31035018 )
2019
36
Severe hemorrhagic cystitis caused by the BK polyomavirus is associated with decreased survival post-allogeneic hematopoietic stem cell transplantation. ( 31054192 )
2019
37
CUA Best-Practice Report: Pediatric hemorrhagic cystitis. ( 31059419 )
2019
38
Interstitial cystitis - intravesical treatment. ( 31066806 )
2019
39
Is there an effective therapy of interstitial cystitis/bladder pain syndrome? ( 31070933 )
2019
40
Variations in bladder pain syndrome/interstitial cystitis (IC) definitions, pathogenesis, diagnostics and treatment: a systematic review and evaluation of national and international guidelines. ( 31073635 )
2019
41
Emphysematous cystitis: Retrospective evaluation of predisposing factors and ultrasound features in 36 dogs and 2 cats. ( 31080265 )
2019
42
Targeting the SHIP1 Pathway Fails to Show Treatment Benefit in Interstitial Cystitis/Bladder Pain Syndrome: Lessons Learned from Evaluating Potentially Effective Therapies in This Enigmatic Syndrome. ( 31090511 )
2019
43
Cystitis-induced bladder pain is Toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: A MAPP Research Network Animal Study. ( 31091120 )
2019
44
A large bladder hematoma resulting from infectious hemorrhagic cystitis after pelvic reconstruction with transvaginal mesh: An unusual complication. ( 31105946 )
2019
45
Clinical characteristics of self-reported nocturia in patients with interstitial cystitis, and effects of bladder hydrodistention (with fulguration of Hunner lesions) on nocturia. ( 30010251 )
2019
46
Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review. ( 30015351 )
2019
47
Comparison of outpatient reimbursement for interstitial cystitis/bladder pain syndrome and rheumatoid arthritis treatment in Taiwan: A nationwide population-based study. ( 30073771 )
2019
48
Current management of radiation cystitis: a review and practical guide to clinical management. ( 30113758 )
2019
49
Stratification of Patients With Interstitial Cystitis/Bladder Pain Syndrome According to the Anatomical Bladder Capacity. ( 30170094 )
2019
50
The Effects of Neurokinin-1 Receptor Antagonist in an Experimental Autoimmune Cystitis Model Resembling Bladder Pain Syndrome/Interstitial Cystitis. ( 30196377 )
2019

Variations for Cystitis

Expression for Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for Cystitis

Pathways related to Cystitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 EGF FZD8 IL6 NGF PTGS2 TLR4
2 12.79 CXCL8 EGF FZD8 IL6 PTGS2
3
Show member pathways
12.65 EGF IL6 NGF TLR4 TNF
4
Show member pathways
12.29 CRP IL6 PTGS2 TNF
5
Show member pathways
12.28 CXCL8 IL6 PTGS2 TNF
6 12.25 FZD8 HBEGF TLR4 TNF
7
Show member pathways
12.25 CXCL8 IL6 PTGS2 TLR4 TNF
8
Show member pathways
12.21 CXCL8 IL6 TLR4 TNF
9
Show member pathways
12.2 CXCL8 HBEGF IL6 NGF TNF
10
Show member pathways
12.17 CXCL8 IL6 PTGS2 TNF
11
Show member pathways
12.12 CXCL8 IL6 TLR4 TNF
12
Show member pathways
12.05 EGF FZD8 HBEGF IL6
13 11.95 EGF FZD8 IL6 PTGS2 TLR4 TNF
14 11.93 CXCL8 IL6 PTGS2 TNF
15 11.85 CXCL8 IL6 NGF TAC1 TACR1 TNF
16 11.84 CXCL8 PTGS2 TLR4 TNF
17 11.83 CXCL8 IL6 TLR4 TNF
18
Show member pathways
11.82 CXCL8 IL6 TLR4
19 11.78 CXCL8 IL6 TLR4
20 11.78 CXCL8 IL6 TLR4 TNF
21
Show member pathways
11.72 CXCL8 PTGS2 TNF
22 11.69 IL6 PTGS2 TNF
23 11.68 CXCL8 IL6 TLR4 TNF
24 11.64 CXCL8 HBEGF IL6
25 11.64 CXCL8 EGF HBEGF UPK3A
26 11.56 CXCL8 EGF IL6 TNF
27
Show member pathways
11.53 CXCL8 IL6 PTGS2 TNF
28 11.51 CXCL8 IL6 PTGS2 TACR1 TLR4 TNF
29 11.5 CXCL8 IL6 PTGS2
30 11.49 HBEGF IL6 TNF
31 11.46 IL6 KNG1 TNF
32 11.45 CXCL8 IL6 TLR4 TNF
33 11.36 CXCL8 IL6 PTGS2 TNF
34 11.31 CXCL8 IL6 TLR4 TNF
35 11.3 IL6 TLR4 TNF
36 10.98 CXCL8 EGF IL6 NGF TNF
37 10.48 TAC1 TACR1
38 10.3 CRP CXCL8 IL6 PTGS2 TNF

GO Terms for Cystitis

Cellular components related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.87 HBEGF P2RX3 TACR1 TLR4 TNF TRPV1
2 extracellular space GO:0005615 9.81 CRP CXCL8 EGF HBEGF IL6 KNG1
3 extracellular region GO:0005576 9.65 CRP CXCL8 EGF HBEGF IL6 KNG1
4 apical plasma membrane urothelial plaque GO:0120001 8.62 UPK1A UPK3A
5 plasma membrane GO:0005886 10.07 CKAP4 EGF FZD8 HBEGF KNG1 P2RX3

Biological processes related to Cystitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 CXCL8 IL6 NGF PTGS2 UMOD
2 angiogenesis GO:0001525 9.93 CXCL8 EGF FZD8 PTGS2
3 positive regulation of gene expression GO:0010628 9.93 CRP EGF IL6 NGF TLR4 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.84 CXCL8 IL6 TLR4 TNF
5 response to organic substance GO:0010033 9.83 P2RX3 PTGS2 TNF
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.82 EGF HBEGF IL6
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 IL6 PTGS2 TNF
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 KNG1 TAC1 TACR1 TRPV1
9 positive regulation of apoptotic process GO:0043065 9.8 IL6 KNG1 NGF PTGS2 TNF TRPV1
10 regulation of inflammatory response GO:0050727 9.78 PTGS2 TLR4 TNF
11 response to glucocorticoid GO:0051384 9.77 IL6 PTGS2 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.74 IL6 TLR4 TNF
13 sensory perception of pain GO:0019233 9.73 PTGS2 TAC1 TRPV1
14 positive regulation of acute inflammatory response GO:0002675 9.64 IL6 TAC1
15 behavioral response to pain GO:0048266 9.63 P2RX3 TRPV1
16 negative regulation of blood vessel diameter GO:0097756 9.62 CRP PTGS2
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.62 TLR4 TNF
18 positive regulation of lymphocyte proliferation GO:0050671 9.61 TAC1 TLR4
19 positive regulation of chemokine production GO:0032722 9.61 IL6 TLR4 TNF
20 tachykinin receptor signaling pathway GO:0007217 9.58 TAC1 TACR1
21 response to pain GO:0048265 9.58 TAC1 TACR1 TRPV1
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.56 HBEGF IL6 PTGS2 TNF
23 positive regulation of neuroinflammatory response GO:0150078 9.55 IL6 TNF
24 cellular response to ATP GO:0071318 9.54 P2RX3 PTGS2 TRPV1
25 positive regulation of fever generation GO:0031622 9.52 PTGS2 TNF
26 urinary bladder smooth muscle contraction GO:0014832 9.51 P2RX3 TRPV1
27 detection of abiotic stimulus GO:0009582 9.48 TAC1 TACR1
28 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
29 inflammatory response GO:0006954 9.32 CRP CXCL8 IL6 KNG1 PTGS2 TAC1
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 PTGS2 TLR4 TNF TRPV1
31 regulation of signaling receptor activity GO:0010469 10 CXCL8 HBEGF IL6 NGF TNF

Molecular functions related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.26 FZD8 KNG1 NGF TLR4
2 growth factor activity GO:0008083 8.92 EGF HBEGF IL6 NGF

Sources for Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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