MCID: CYS018
MIFTS: 58

Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Cystitis

MalaCards integrated aliases for Cystitis:

Name: Cystitis 12 54 44 15 62 17 70 32
Infective Cystitis 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1679
ICD9CM 34 595
MeSH 44 D003556
NCIt 50 C26738
SNOMED-CT 67 38822007
ICD10 32 N30 N30.9
UMLS 70 C0010692 C0600041

Summaries for Cystitis

PubMed Health : 62 About cystitis: Many women know the symptoms of cystitis (a urinary tract infection, or UTI) only too well: frequent trips to the bathroom and a stinging and burning sensation when passing urine. Although these symptoms are often very unpleasant, there are effective treatments. Uncomplicated cystitis usually clears up without any problems. Unfortunately, there is no sure-fire way to reliably prevent cystitis. And a lot of the common strategies women may use in day-to-day life have not yet been scientifically tested. This article is about acute cystitis – a bladder infection often also referred to as a urinary tract infection (UTI). It is not about chronic bladder problems such as interstitial cystitis. It also doesn't include information about treating cystitis in pregnant women.

MalaCards based summary : Cystitis, also known as infective cystitis, is related to hemorrhagic cystitis and interstitial cystitis. An important gene associated with Cystitis is UMOD (Uromodulin), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Disease Ontology : 12 A bladder disease that is characterized by inflammation of the bladder.

Wikipedia : 73 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 993)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic cystitis 33.0 TNF TLR4 IL2
2 interstitial cystitis 32.5 UPK3A UPK1A UMOD TRPV1 TACR1 TAC1
3 urinary tract infection 32.4 UMOD TLR4 CRP
4 bladder tuberculosis 32.4 UPK3A HBEGF
5 acute cystitis 32.3 VIM UPK3A UPK1A UMOD TNF TLR4
6 chronic cystitis 32.2 UPK3A UPK1A TRPV1 TLR4 TAC1 P2RX3
7 urethral syndrome 32.1 TNF TAC1 P2RX3 NGF IL6 CXCL8
8 pyelonephritis 31.5 UMOD TNF TLR4 IL6 CXCL8 CRP
9 bacteriuria 31.5 UMOD TLR4 IL6 CXCL8 CRP
10 graft-versus-host disease 31.4 TNF IL6 IL2
11 hydronephrosis 31.4 UPK3A IL6 EGF CXCL8 CRP
12 pyuria 31.4 UPK3A IL6 CXCL8 CRP
13 prostatitis 31.3 TP53 TNF IL6 IL4 IL2 CXCL8
14 acute graft versus host disease 31.3 TNF IL4 IL2
15 fibromyalgia 31.2 TNF TACR1 NGF IL6 CXCL8 CRP
16 acute pyelonephritis 31.1 IL6 CXCL8 CRP
17 urinary tract obstruction 31.1 UPK3A UMOD HBEGF EGF CRP
18 urethritis 31.1 TNF TLR4 IL6 CXCL8 CRP
19 vesicoureteral reflux 1 31.0 UPK3A UPK1A UMOD CXCL8 CRP
20 vaginitis 31.0 TNF IL6 CXCL8
21 bladder cancer 31.0 UPK3A UPK1A TP53 TNF IL2 HBEGF
22 bacterial infectious disease 30.9 TNF TLR4 IL6 CXCL8 CRP
23 acute kidney failure 30.9 UMOD KNG1 EGF
24 chronic fatigue syndrome 30.9 TNF TLR4 IL6 IL4 IL2 CXCL8
25 irritable bowel syndrome 30.8 TRPV1 TNF TLR4 TAC1 NGF IL6
26 peritonitis 30.8 TNF TLR4 IL6 IL4 CXCL8 CRP
27 vaginal discharge 30.8 TNF IL6 CXCL8 CRP
28 ileus 30.8 TNF IL6 CRP
29 pyelitis 30.8 UPK3A UPK1A UMOD TNF TLR4 IL6
30 allergic disease 30.8 TNF TLR4 IL6 IL4 IL2 CXCL8
31 cholecystitis 30.7 TP53 TLR4 EGF
32 neurogenic bladder 30.7 UPK3A UPK1A TRPV1 TACR1 TAC1 P2RX3
33 chlamydia 30.7 TNF TLR4 IL6 IL4 CXCL8 CRP
34 systemic lupus erythematosus 30.7 TP53 TNF TLR4 IL6 IL4 IL2
35 autoimmune disease 30.7 TNF IL6 IL4 IL2 CXCL8 CRP
36 toxic shock syndrome 30.6 TNF TLR4 IL6 IL4 IL2 CXCL8
37 aplastic anemia 30.6 TP53 TNF IL6 IL4 IL2 CXCL8
38 chronic pyelonephritis 30.6 UMOD TLR4 CRP
39 allergic rhinitis 30.6 NGF KNG1 IL4 CXCL8
40 gastroenteritis 30.5 TNF IL6 IL4 CXCL8 CRP
41 purpura 30.5 TNF IL6 IL4 CRP
42 disease by infectious agent 30.5 TNF TLR4 IL6 IL4 IL2 CRP
43 rhinitis 30.5 TNF NGF KNG1 IL6 IL4 CXCL8
44 exanthem 30.5 TNF IL6 IL2 CXCL8 CRP
45 gastritis 30.5 TP53 TNF TLR4 IL6 CXCL8
46 schistosomiasis 30.5 TP53 TNF IL4 IL2
47 polyneuropathy 30.5 TNF NGF IL6 CRP
48 neutropenia 30.5 TP53 TNF IL6 IL2 CXCL8 CRP
49 toxoplasmosis 30.5 TNF TLR4 IL6 IL4
50 typhoid fever 30.5 TNF TLR4 IL6 CRP

Comorbidity relations with Cystitis via Phenotypic Disease Network (PDN): (show all 30)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bladder Cancer Bladder Neck Obstruction
Bronchitis Chronic Kidney Disease
Decubitus Ulcer Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hydronephrosis Hypertension, Essential
Hypothyroidism Iron Deficiency Anemia
Neurogenic Bladder Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Prostatic Hypertrophy Protein-Energy Malnutrition
Pyelonephritis Radiation Cystitis
Schizophreniform Disorder Transient Cerebral Ischemia
Urethral Stricture Urethritis

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to Cystitis

Symptoms & Phenotypes for Cystitis

MGI Mouse Phenotypes related to Cystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 HBEGF IL2 IL6 KNG1 NGF P2RX3
2 homeostasis/metabolism MP:0005376 10.22 CRP HBEGF IL2 IL4 IL6 KNG1
3 cardiovascular system MP:0005385 10.21 CRP HBEGF IL2 IL6 NGF P2RX3
4 immune system MP:0005387 10.07 CRP EGF IL2 IL4 IL6 P2RX3
5 integument MP:0010771 9.93 EGF HBEGF IL4 IL6 NGF P2RX3
6 renal/urinary system MP:0005367 9.56 IL4 IL6 TAC1 TLR4 TP53 TRPV1
7 respiratory system MP:0005388 9.32 HBEGF IL2 IL4 IL6 P2RX3 TACR1

Drugs & Therapeutics for Cystitis

PubMed Health treatment related to Cystitis: 62

For many women, cystitis is a one-time unpleasant problem. In others, it may keep coming back. Antibiotics have been proven to effectively relieve acute cystitis , and they usually work quickly. There are also some home remedies that may help, like drinking plenty of fluids or applying heat. Herbal products are available too.

Drugs for Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 242)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 4 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3
Fosfomycin Approved Phase 4 23155-02-4 446987
4
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
5
BCG vaccine Approved, Investigational Phase 4
6
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
7
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
8
Cefazolin Approved Phase 4 25953-19-9 656510 33255
9
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
10
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
11
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
12
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
13
Sulfamethoxazole Approved Phase 4 723-46-6 5329
14
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
15
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
16
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
17
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
18
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
19
Ibuprofen Approved Phase 4 15687-27-1 3672
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
Polyestradiol phosphate Approved Phase 4 28014-46-2
22
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
23
Ferrous fumarate Approved Phase 4 141-01-5
24
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
25
Norethindrone Approved Phase 4 68-22-4 6230
26
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
27
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
28
Methylene blue Approved, Investigational Phase 4 61-73-4
29
Belladonna Approved, Experimental Phase 4
30
Ethanol Approved Phase 4 64-17-5 702
31
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
32
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
33
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
34
Amdinocillin Investigational, Withdrawn Phase 4 32887-01-7 36273
35
Acriflavine Experimental Phase 4 65589-70-0
36 Gentamicins Phase 4
37 Solifenacin succinate Phase 4 242478-38-2
38 Cephradine Phase 4
39 cephalothin Phase 4
40 Parasympatholytics Phase 4
41 Cholinergic Antagonists Phase 4
42 Amoxicillin-Potassium Clavulanate Combination Phase 4
43 Cholinergic Agents Phase 4
44 cefuroxime axetil Phase 4
45 Clavulanic Acids Phase 4
46 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
47 Muscarinic Antagonists Phase 4
48 Cytochrome P-450 Enzyme Inhibitors Phase 4
49 Antirheumatic Agents Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 240)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Randomized Placebo-Controlled Trial of Gentamicin Bladder Instillation for the Prevention of Urinary Tract Infection in Adults at High Risk for Cystitis Due to Intermittent Catheterization Unknown status NCT01884467 Phase 4 Gentamicin;Placebo
3 Randomised Clinical Trial Comparing Fosfomycin vs. Nitrofurantoin for Treatment of Uncomplicated Lower Urinary Tract Infection in Female Adults at Increased Risk of Antibiotic-resistant Bacterial Infection Unknown status NCT01966653 Phase 4 nitrofurantoin;fosfomycin
4 Solifenacin vs Levofloxacin vs Lornoxicam for Management of Intravesical Instillation of Bacillus Calmette-Guerin (BCG) Side Effects A Single Blinded Randomised Controlled Study Unknown status NCT03038321 Phase 4 sofenacin;Tavanic;Xefo
5 Botulinum A Toxin Intravesical Injections Versus Bladder Overdistension in the Treatment of Patients With Painful Bladder Syndrome: A Prospective Randomized Study Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
6 Efficacy of Oxybutynin in Paediatric Cystitis Completed NCT03877289 Phase 4 Oxybutynin;Antibiotics
7 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
8 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
9 The Impact of Injection Location on the Efficacy of Intravesicular Onabotulinumtoxin A in Interstitial Cystitis--Phase 4 Completed NCT02297100 Phase 4 Onabotulinumtoxin A
10 Botox (Botulinum Toxin A) as a Treatment for Interstitial Cystitis in Women: A Randomized Placebo Controlled Trial Completed NCT00194610 Phase 4 Botox
11 To Evaluate the Efficacy, Tolerability, and Safety of Intranasal Ketorolac Tromethamine (Sprix) as an Option for Acute (up to 5 Days) Pain Management Adult Interstitial Cystitis Patients Experiencing a Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
12 Use of Standardized Delegation Form in Diagnosing and Treating Acute Cystitis in Primary Care Facilities. Completed NCT01132131 Phase 4
13 A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department Completed NCT01749605 Phase 4 Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days;ciprofloxacin 250 mg BID x 3 days
14 Efficacy of Combined Intravesical Therapy With Hyaluronic Acid and Chondroitin Sulphate in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract: a Multicenter, Prospective Study Completed NCT02366676 Phase 4 hyaluronic acid and chondroitin sulphate
15 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis in Adult, Non-pregnant Women Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
16 Management of Sub-Clinical Bacteriuria in Pregnancy: A Feasibility Trial Completed NCT03275623 Phase 4 Antibiotic
17 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository: A Randomized, Double-Blind, Placebo-Controlled Trial (ROBIN Trial) Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
18 Deciphering the Hormonal and Nociceptive Mechanisms Underlying Bladder Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
19 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
20 Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis Active, not recruiting NCT03379389 Phase 4 Methenamine + Methylthioninium;Methenamine + Methylthioninium + Acriflavine + Atropa belladona;Antibiotics
21 IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder Syndrome a Randomized Placebo-controlled Prospective Trial Not yet recruiting NCT04313972 Phase 4 low-dose naltrexone;Placebo oral tablet
22 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
23 Prospective Randomised Trial Comparing Intravesical Chondroitin Sulphate 2% and DMSO in the Treatment of Painful Bladder Syndrome/ Interstitial Cystitis Terminated NCT04268810 Phase 4
24 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
25 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Evaluation of the Efficacy and Tolerability of Two Different Doses of ELMIRON for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
26 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective, Randomised,Placebo-controlled, Double-blind Study Terminated NCT01879930 Phase 4 doxycycline;placebo
27 Nitrofurantoin Macrocrystals 3 Days Vs. 7 Days in the Treatment of Women With Uncomplicated Cystitis Withdrawn NCT00361998 Phase 4 NITROFURANTOIN MACROCRYSTALS
28 The LEADERSHIP 301 Trial: A 12-Week, Randomized, Multi-Center, Double-Blind, Placebo-Controlled, 3-Arm, Parallel-Group, Phase 3 Trial to Evaluate the Efficacy and Safety of 2 Doses of AQX-1125 Targeting the Src Homology 2-containing Inositol-5'-Phosphatase 1 (SHIP1) Pathway in Subjects With Interstitial Cystitis/Bladder Pain Syndrome Followed by an Extension Period Unknown status NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
29 A Double-Blind, Randomized Study of Puncturing Versus Non-Puncturing Acupuncture for the Treatment of Interstitial Cystitis Symptoms Unknown status NCT00094874 Phase 3
30 Recurrent Urinary Tract Infections in Adult Women: a Pilot Study With Oral D Mannose Completed NCT01808755 Phase 3 trimethoprim/sulfamethoxazole
31 An Investigator Initiated, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Humira® (Adalimumab) For The Treatment of Interstitial Cystitis(IC) Completed NCT01295814 Phase 3 Adalimumab
32 Randomized Controlled Trial Comparing Two Different Bladder Instillation Treatments for Interstitial Cystitis/Bladder Pain Syndrome Completed NCT03463915 Phase 3 Bladder instillation WITH triamcinolone acetonide;Bladder instillation WITHOUT triamcinolone acetonide
33 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
34 Explorative Study on the Use of Omalizumab in Patients Suffering From Interstitial Cystitis/Painful Bladder Syndrome Completed NCT01294878 Phase 3 omalizumab
35 A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients Completed NCT00124306 Phase 3 Amitriptyline
36 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
37 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Completed NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen
38 Multicentre, Prospective, Comparative, Randomized, Double-blind, Double-dummy Study to Assess the Efficacy and Safety of Cefditoren Pivoxil vs. Ciprofloxacin in Uncomplicated Acute Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
39 Multicenter, Randomized, Double-blind, Placebo-controlled Parallel Group Trial to Evaluate the Efficacy and Tolerability of a Phytotherapy Combination (Aqualibra) in Patients With Uncomplicated Cystitis Completed NCT04032574 Phase 3
40 Upfront Autologous Hematopoietic Stem Cell Transplantation Versus Immunosuppressive Medication in Early Diffuse Cutaneous Systemic Sclerosis: an International Multicentre, Open-label, Randomized Con-trolled Trial Recruiting NCT04464434 Phase 3
41 Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR105) for the Treatment of Patients With Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant (HCT) Recruiting NCT04390113 Phase 3
42 A Phase III, Randomized, Multicenter, Parallel-Group, Double-Blind, Double-Dummy Study in Adolescent and Adult Female Participants Comparing the Efficacy and Safety of Gepotidacin to Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infection (Acute Cystitis) Recruiting NCT04187144 Phase 3 Gepotidacin;Placebo matching nitrofurantoin;Nitrofurantoin;Placebo matching gepotidacin
43 A Phase III, Randomized, Multicenter, Parallel-Group, Double-Blind, Double-Dummy Study in Adolescent and Adult Female Participants Comparing the Efficacy and Safety of Gepotidacin to Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infection (Acute Cystitis) Recruiting NCT04020341 Phase 3 Gepotidacin;Placebo matching nitrofurantoin;Nitrofurantoin;Placebo matching gepotidacin
44 A Pilot Study of the Effects of Mirabegron on Symptoms in Patients With Interstitial Cystitis Terminated NCT02787083 Phase 3 Mirabegron;Placebo
45 A Randomized Multicenter Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of Mycophenolate Mofetil (CellCept) for the Treatment of Refractory Interstitial Cystitis (IC) Terminated NCT00451867 Phase 3 Mycophenolate Mofetil;Mycofenolate Mofetil (MMF);Placebo
46 Randomized Study of Different Non-myeloablative Conditioning Regimens With Hematopoietic Stem Cell Support in Patients With Scleroderma (Autologous Systemic Sclerosis Immune Suppression Trial - II ASSIST-IIb) Terminated NCT01445821 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;Filgrastim;Fludarabine
47 Randomized Trial of Busulfan or Total Body Irradiation Conditioning Regimens for Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
48 Maximizing Outcome of Multiple Sclerosis Transplantation: "MOST" Trial Terminated NCT03342638 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF
49 A Phase III Non-Inferiority Open-label Multicenter Randomized Clinical Trial to Compare CEPHALOSPORIN to NORFLOXACIN in the Treatment of Acute Cystitis Withdrawn NCT01527019 Phase 3 Norfloxacin;Cephalosporins;Cephalosporins
50 Randomized Controlled Trial for Efficacy of Botulinum Toxin Type A in Treatment of Patients Suffering Bladder Pain Syndrome/Interstitial Cystitis With Hunners' Lesions Unknown status NCT01437579 Phase 2

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Carboprost
Ciprofloxacin
Mesna
Methenamine
methenamine hippurate
methenamine mandelate
METHENAMINE SULFOSALICYLATE

Cochrane evidence based reviews: cystitis

Genetic Tests for Cystitis

Anatomical Context for Cystitis

MalaCards organs/tissues related to Cystitis:

40
Bone Marrow, Kidney, Bone, Prostate, Spinal Cord, Breast, Cervix

Publications for Cystitis

Articles related to Cystitis:

(show top 50) (show all 11570)
# Title Authors PMID Year
1
Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. 54 61
19996110 2010
2
Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. 61 54
16500917 2006
3
GAP-43 immunoreactivity of subepithelial and detrusor muscle nerve fibres in patients with refractory idiopathic detrusor overactivity. 61 54
15924356 2005
4
Potential therapeutic targets for neurokinin-1 receptor antagonists. 61 54
15155133 2004
5
Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. 61 54
10702392 2000
6
Increased expression of growth-associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced cystitis. 61 54
10536274 1999
7
[Evaluation of N-acetyl-beta glucosaminidase in upper and lower urinary tract infections in childhood. Clinical study of 168 children]. 61 54
9064498 1996
8
Tamm-Horsfall protein in bladder tissue. Morphologic spectrum and clinical significance. 54 61
8179076 1994
9
Urinary N-acetyl-beta-glucosaminidase and the selection of children for radiologic evaluation after urinary tract infection. 54 61
2371096 1990
10
Intravesical Instillation of Kangfuxin Liquid Combined with Thrombin and Epidermal Growth Factor for Radiation-induced Hemorrhagic Cystitis in Patients with Cervical Cancer: A report of 34 cases. 61
33645436 2021
11
The role of early diagnosis of emphysematous cystitis: A case report and literature review. 61
33643846 2021
12
Loss of Fibroblast Growth Factor Receptor 2 (FGFR2) Leads to Defective Bladder Urothelial Regeneration after Cyclophosphamide Injury. 61
33385344 2021
13
Association between case signalment and disease diagnosis in urinary bladder disease in Australian cats and dogs. 61
33797303 2021
14
Prevalence of urinary system, pelvic organ, and genital tract disorders among women with type 1 diabetes in Germany. 61
32980281 2021
15
Application of hyaluronic acid in patients with interstitial cystitis. 61
33480631 2021
16
Factors associated with treatment outcomes after intravesical hyaluronic acid therapy in women with refractory interstitial cystitis: A prospective, multicenter study. 61
33784267 2021
17
The effect of antimicrobial treatment on mortality associated with urinary tract disease in mink kits (Neovison vison). 61
33794953 2021
18
Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics. 61
33538002 2021
19
Recurrent UTIs and cystitis symptoms in women. 61
33786541 2021
20
General practitioners' clinical practice on the management of cystitis in Normandy, France: A clinical vignettes-based study. 61
32929837 2021
21
Patients' experience of haemorrhagic cystitis after Haematopoietic Stem Cell Transplantation: Findings from a phenomenological study. 61
33677414 2021
22
Clinical and microbiological characterization of subclinical bacteriuria and sporadic bacterial cystitis in dogs with spontaneous hypercortisolism. 61
33609989 2021
23
Pentosan polysulfate maculopathy versus age-related macular degeneration: comparative assessment with multimodal imaging. 61
33722504 2021
24
Burden of infections on older patients presenting to general practice: a registry-based study. 61
32975281 2021
25
Comparison of Total Body Irradiation-based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL. 61
33625092 2021
26
A mixed-method simulated patient approach to explore implicit bias in health care: A feasibility study in community pharmacy. 61
32417071 2021
27
Ifosfamide-related encephalopathy with severe clinical presentations in children with cancer. 61
33779369 2021
28
Safety evaluation of the canine osteosarcoma vaccine, live Listeria vector. 61
32729979 2021
29
Prospective analysis of BKV hemorrhagic cystitis in children and adolescents undergoing hematopoietic cell transplantation. 61
33661334 2021
30
Antivirals against human polyomaviruses: Leaving no stone unturned. 61
33729628 2021
31
Well-differentiated neuroendocrine tumors of the lower urinary tract: biologic behavior of a rare entity. 61
33301750 2021
32
Incidence of hemorrhagic cystitis after cyclophosphamide therapy with or without mesna: A cohort study and comprehensive literature review. 61
32356687 2021
33
Possible nosocomial transmission of virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. 61
33439306 2021
34
Hemorrhagic cystitis: A successful outcome for a challenging complication in stem cell transplant. 61
33747409 2021
35
Effectiveness of hyperbaric oxygen therapy for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. 61
33728556 2021
36
Risk Factors of BK Viral Hemorrhagic Cystitis in Allogenic Hematopoietic Stem Cell Transplantation. 61
33724650 2021
37
Sex Differences in Population Dynamics during Formation of Kidney Bacterial Communities by Uropathogenic Escherichia coli. 61
33468577 2021
38
Comparison of deep phenotyping features of UCPPS with and without Hunner lesion: A MAPP-II Research Network Study. 61
33604963 2021
39
Pathogenesis of Proteus mirabilis in Catheter-Associated Urinary Tract Infections. 61
33691318 2021
40
Detection of Urothelial Bladder Cancer Based on Urine and Tissue Telomerase Activity Measured by Novel RT-TRAP-2PCR Method. 61
33806392 2021
41
Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines. 61
33651159 2021
42
Endovascular Interventional Radiology of the Urogenital Tract. 61
33802895 2021
43
BK polyomavirus-pathogen, paradigm and puzzle. 61
31891401 2021
44
Lower urinary tract symptoms in adolescent girls: a questionnaire-based study. 61
33573859 2021
45
Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide. 61
33688971 2021
46
Pneumoperitoneum and peritonitis secondary to perforation of an infected bladder. 61
33744799 2021
47
Seroprevalence of Infection with Feline Morbilliviruses Is Associated with FLUTD and Increased Blood Creatinine Concentrations in Domestic Cats. 61
33808115 2021
48
Antimicrobial Resistance Patterns of Urinary Escherichia coli Among Outpatients in Washington State, 2013-2017: Associations with Age and Sex. 61
33768228 2021
49
Examination of pelvic floor muscle elasticity in patients with interstitial cystitis/bladder pain syndrome using real-time tissue elastography. 61
33740121 2021
50
Interstitial Cystitis/Bladder Pain Syndrome as Referred Pain From Injured T12/L1 Nerves: Symptomatic Improvement With Resection of Ilioinguinal and Iliohypogastric Nerves. 61
33279610 2021

Variations for Cystitis

Expression for Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for Cystitis

Pathways related to Cystitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 VIM TP53 TNF NGF IL6 IL4
2
Show member pathways
13.57 TP53 TNF NGF IL6 IL4 IL2
3
Show member pathways
13.45 TP53 TNF TLR4 NGF IL6 IL4
4
Show member pathways
13.38 VIM TP53 TNF IL6 IL4 IL2
5
Show member pathways
13.34 TRPV1 P2RX3 NGF IL6 IL2 HBEGF
6
Show member pathways
13.33 TNF NGF IL6 IL4 IL2 HBEGF
7
Show member pathways
13.22 TP53 TNF TLR4 KNG1 IL6 IL2
8
Show member pathways
13.09 TP53 NGF IL6 IL2 HBEGF EGF
9
Show member pathways
13.06 NGF IL6 IL4 IL2 HBEGF EGF
10
Show member pathways
12.97 TP53 TNF TLR4 NGF IL6 IL4
11
Show member pathways
12.89 VIM TNF IL6 IL4 IL2 CXCL8
12 12.85 TP53 KNG1 IL6 IL4 IL2 EGF
13
Show member pathways
12.83 VIM TP53 TNF TLR4 IL6 IL2
14
Show member pathways
12.75 TNF TLR4 NGF IL6 IL2 EGF
15
Show member pathways
12.62 TNF TLR4 IL6 IL4 IL2
16
Show member pathways
12.58 VIM TNF TLR4 IL6 IL4 IL2
17 12.41 TACR1 P2RX3 NGF EGF
18 12.36 TP53 TNF IL6 IL2
19
Show member pathways
12.36 TNF IL6 IL4 CXCL8
20
Show member pathways
12.36 TP53 TNF TLR4 IL6 CXCL8
21
Show member pathways
12.35 TNF IL6 IL2 CXCL8
22
Show member pathways
12.34 TP53 TNF IL6 IL4 IL2 CRP
23
Show member pathways
12.33 TP53 IL6 HBEGF EGF
24 12.32 TP53 TNF TLR4 HBEGF
25
Show member pathways
12.28 TRPV1 NGF KNG1 HBEGF
26
Show member pathways
12.28 TNF TLR4 IL6 CXCL8
27 12.25 TNF TLR4 IL6 CXCL8
28 12.22 TP53 TNF TLR4 IL6 EGF
29
Show member pathways
12.21 TNF TLR4 IL6 IL4 CXCL8
30 12.09 TNF TACR1 TAC1 NGF IL6 CXCL8
31 12.08 TNF TLR4 IL6 IL2 CXCL8
32 12.04 TNF IL6 IL4 IL2
33 11.97 TNF TLR4 IL6 CXCL8
34 11.92 TNF TLR4 IL6 CXCL8
35
Show member pathways
11.82 TNF TLR4 IL6 IL2
36 11.82 TNF TLR4 IL6 CXCL8
37 11.81 TNF IL4 IL2
38
Show member pathways
11.81 TNF IL4 IL2 CXCL8
39 11.8 VIM NGF EGF
40 11.79 TP53 IL6 IL4 IL2 CXCL8
41 11.77 TNF IL6 IL2
42
Show member pathways
11.77 TP53 TNF NGF IL6 IL4 IL2
43 11.74 TNF TLR4 IL6 IL4
44
Show member pathways
11.71 TNF IL6 IL2 CXCL8
45 11.7 IL6 HBEGF CXCL8
46 11.69 UPK3A TP53 HBEGF EGF CXCL8
47 11.69 VIM TP53 TNF IL6 IL4 CXCL8
48 11.65 TNF TLR4 IL6 CXCL8
49 11.58 TP53 IL6 CXCL8
50 11.57 TNF TLR4 IL6 CXCL8

GO Terms for Cystitis

Cellular components related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 VIM UPK3A UPK1A UMOD TRPV1 TNF
2 extracellular region GO:0005576 9.73 UMOD TNF TAC1 NGF KNG1 IL6
3 extracellular space GO:0005615 9.4 UMOD TNF TAC1 NGF KNG1 IL6
4 apical plasma membrane urothelial plaque GO:0120001 9.16 UPK3A UPK1A

Biological processes related to Cystitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.04 UMOD TP53 NGF IL6 CXCL8
2 immune response GO:0006955 9.99 TNF TLR4 IL6 IL4 IL2 CXCL8
3 positive regulation of apoptotic process GO:0043065 9.91 TRPV1 TP53 TNF NGF KNG1 IL6
4 apoptotic signaling pathway GO:0097190 9.83 UMOD TNF TLR4
5 positive regulation of interferon-gamma production GO:0032729 9.8 TNF TLR4 IL2
6 positive regulation of T cell proliferation GO:0042102 9.8 IL6 IL4 IL2
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 TNF IL6 HBEGF
8 positive regulation of interleukin-8 production GO:0032757 9.78 TNF TLR4 IL6
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 TP53 IL6 HBEGF EGF
10 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF TLR4 IL6
11 cellular response to lipopolysaccharide GO:0071222 9.77 VIM TNF TLR4 IL6 CXCL8
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 TRPV1 TNF TLR4
13 positive regulation of B cell proliferation GO:0030890 9.73 TLR4 IL4 IL2
14 positive regulation of chemokine production GO:0032722 9.72 TNF TLR4 IL6
15 positive regulation of cytosolic calcium ion concentration GO:0007204 9.72 TRPV1 TACR1 TAC1 KNG1 IL2
16 positive regulation of interleukin-10 production GO:0032733 9.71 TLR4 IL6 IL4
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IL6 IL4 IL2
18 microglial cell activation GO:0001774 9.7 TRPV1 TNF IL4
19 cytokine-mediated signaling pathway GO:0019221 9.7 VIM TP53 TNF IL6 IL4 IL2
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.67 TNF TLR4 IL6
21 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.66 TNF TLR4
22 response to salt stress GO:0009651 9.66 TP53 TNF
23 negative regulation of T-helper 17 cell differentiation GO:2000320 9.65 IL4 IL2
24 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IL4 IL2
25 positive regulation of gene expression GO:0010628 9.65 VIM TP53 TNF TLR4 NGF IL6
26 positive regulation of lymphocyte proliferation GO:0050671 9.64 TLR4 TAC1
27 tachykinin receptor signaling pathway GO:0007217 9.63 TACR1 TAC1
28 response to pain GO:0048265 9.63 TRPV1 TACR1 TAC1
29 vascular endothelial growth factor production GO:0010573 9.61 TNF IL6
30 positive regulation of mononuclear cell migration GO:0071677 9.59 TNF IL4
31 urinary bladder smooth muscle contraction GO:0014832 9.58 TRPV1 P2RX3
32 detection of abiotic stimulus GO:0009582 9.57 TACR1 TAC1
33 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
34 inflammatory response GO:0006954 9.32 UMOD TRPV1 TNF TLR4 TACR1 TAC1

Molecular functions related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IL4 IL2 CXCL8
2 growth factor activity GO:0008083 9.1 NGF IL6 IL4 IL2 HBEGF EGF

Sources for Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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