MCID: CYS018
MIFTS: 59

Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Cystitis

MalaCards integrated aliases for Cystitis:

Name: Cystitis 12 54 43 15 62 17 71 32
Infective Cystitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1679
ICD9CM 34 595 595.9
MeSH 43 D003556
NCIt 49 C26738
SNOMED-CT 67 38822007
ICD10 32 N30 N30.9
UMLS 71 C0010692 C0600041

Summaries for Cystitis

PubMed Health : 62 About cystitis: Many women know the symptoms of cystitis (a urinary tract infection, or UTI) only too well: frequent trips to the bathroom and a stinging and burning sensation when passing urine. Although these symptoms are often very unpleasant, there are effective treatments. Uncomplicated cystitis usually clears up without any problems. Unfortunately, there is no sure-fire way to reliably prevent cystitis. And a lot of the common strategies women may use in day-to-day life have not yet been scientifically tested. This article is about acute cystitis – a bladder infection often also referred to as a urinary tract infection (UTI). It is not about chronic bladder problems such as interstitial cystitis. It also doesn't include information about treating cystitis in pregnant women.

MalaCards based summary : Cystitis, also known as infective cystitis, is related to chronic cystitis and acute cystitis. An important gene associated with Cystitis is UMOD (Uromodulin), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Piroxicam and Lornoxicam have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and bone marrow, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A bladder disease that is characterized by inflammation of the bladder.

Wikipedia : 74 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 911)
# Related Disease Score Top Affiliating Genes
1 chronic cystitis 34.4 UPK3A UPK1A TRPV1 TAC1 P2RX3 NGF
2 acute cystitis 34.4 VIM UPK3A UPK1A UMOD TNF TLR4
3 interstitial cystitis 34.2 UPK3A UPK1A UMOD TRPV1 TACR1 TAC1
4 urethral syndrome 33.4 TAC1 P2RX3 NGF IL6 CXCL8
5 pyuria 31.9 IL6 CXCL8 CRP
6 pyelonephritis 31.9 UMOD TNF TLR4 IL6 CXCL8 CRP
7 bacteriuria 31.9 UMOD TLR4 IL6 CXCL8 CRP
8 graft-versus-host disease 31.8 TNF IL6 IL2
9 hydronephrosis 31.7 UPK3A IL6 EGF CXCL8 CRP
10 acute graft versus host disease 31.7 TNF IL4 IL2
11 prostatitis 31.7 TP53 TNF IL6 IL4 IL2 CXCL8
12 acute pyelonephritis 31.5 IL6 CXCL8 CRP
13 urinary tract obstruction 31.5 UPK3A UMOD HBEGF EGF CRP
14 fibromyalgia 31.5 TNF TACR1 NGF IL6 IL2 CXCL8
15 urethritis 31.5 TNF TLR4 IL6 CXCL8 CRP
16 bladder cancer 31.5 UPK3A UPK1A TP53 TNF IL2 HBEGF
17 vesicoureteral reflux 1 31.4 UPK3A UPK1A UMOD CXCL8 CRP
18 bacterial infectious disease 31.4 TNF TLR4 IL6 CXCL8 CRP
19 neurogenic bladder 31.4 UPK3A TRPV1 TACR1 TAC1 P2RX3 NGF
20 autoimmune disease 31.3 TNF IL6 IL4 IL2 CXCL8 CRP
21 irritable bowel syndrome 31.3 TRPV1 TNF TLR4 TACR1 TAC1 NGF
22 vaginal discharge 31.3 IL6 CXCL8 CRP
23 vaginitis 31.3 TNF TLR4 IL6 CXCL8
24 acute kidney failure 31.3 UMOD KNG1 EGF
25 chronic fatigue syndrome 31.2 TNF TLR4 IL6 IL4 IL2 CXCL8
26 peritonitis 31.2 TNF TLR4 IL6 IL4 CXCL8 CRP
27 ileus 31.1 TNF IL6 CRP
28 allergic hypersensitivity disease 31.1 TNF TLR4 KNG1 IL4 IL2 CXCL8
29 cholecystitis 31.1 TP53 TLR4 EGF
30 diarrhea 31.1 TNF TLR4 TAC1 IL6 IL2 CXCL8
31 pyelitis 31.1 UPK3A UPK1A UMOD TNF TLR4 IL6
32 chlamydia 31.0 TNF TLR4 IL6 IL4 CXCL8 CRP
33 paine syndrome 31.0 TRPV1 TACR1 TAC1 P2RX3 NGF KNG1
34 cytomegalovirus infection 31.0 TNF IL6 CXCL8
35 aplastic anemia 31.0 TP53 TNF IL6 IL4 IL2 CXCL8
36 endocarditis 30.9 TNF IL6 CXCL8 CRP
37 exanthem 30.9 TNF IL6 IL2 CXCL8 CRP
38 conjunctivitis 30.9 TNF IL6 IL4 IL2 CXCL8
39 purpura 30.9 TNF IL6 IL4 CRP
40 spinal cord injury 30.9 TNF IL6 CXCL8
41 gastroenteritis 30.9 TNF IL6 IL4 CXCL8 CRP
42 allergic rhinitis 30.9 NGF KNG1 IL4 CXCL8
43 toxic shock syndrome 30.9 TNF TLR4 IL6 IL4 IL2 CXCL8
44 schistosomiasis 30.9 TP53 TNF IL4 IL2
45 rhinitis 30.9 TNF NGF KNG1 IL6 IL4 CXCL8
46 typhoid fever 30.9 TNF TLR4 IL6 CRP
47 pancreatitis 30.9 TP53 TNF IL6 CRP
48 trichomoniasis 30.9 TNF IL6 IL2 CXCL8
49 colitis 30.9 TNF TLR4 IL6 IL4 IL2 CXCL8
50 anxiety 30.9 TNF TAC1 NGF IL6 CRP

Comorbidity relations with Cystitis via Phenotypic Disease Network (PDN): (show all 29)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bladder Cancer Bladder Neck Obstruction
Bronchitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Neurogenic Bladder
Osteoporosis Paralytic Ileus
Parkinson Disease, Late-Onset Prostatic Hypertrophy
Protein-Energy Malnutrition Pyelonephritis
Radiation Cystitis Schizophreniform Disorder
Transient Cerebral Ischemia Urethral Stricture
Urethritis

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to Cystitis

Symptoms & Phenotypes for Cystitis

MGI Mouse Phenotypes related to Cystitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.28 HBEGF IL2 IL6 KNG1 NGF P2RX3
2 cardiovascular system MP:0005385 10.25 CRP HBEGF IL2 IL6 NGF P2RX3
3 homeostasis/metabolism MP:0005376 10.24 CRP HBEGF IL2 IL4 IL6 NGF
4 immune system MP:0005387 10.13 CRP EGF IL2 IL4 IL6 P2RX3
5 integument MP:0010771 10.03 EGF HBEGF IL4 IL6 NGF P2RX3
6 renal/urinary system MP:0005367 9.76 IL4 IL6 TAC1 TLR4 TP53 TRPV1
7 respiratory system MP:0005388 9.65 HBEGF IL2 IL4 IL6 P2RX3 TACR1
8 vision/eye MP:0005391 9.28 EGF IL2 IL4 IL6 NGF TLR4

Drugs & Therapeutics for Cystitis

PubMed Health treatment related to Cystitis: 62

For many women, cystitis is a one-time unpleasant problem. In others, it may keep coming back. Antibiotics have been proven to effectively relieve acute cystitis , and they usually work quickly. There are also some home remedies that may help, like drinking plenty of fluids or applying heat. Herbal products are available too.

Drugs for Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 308)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Piroxicam Approved, Investigational Phase 4 36322-90-4 5280452 54676228
2
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
5
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
6
Ibuprofen Approved Phase 4 15687-27-1 3672
7
Morphine Approved, Investigational Phase 4 57-27-2 5288826
8
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Cycloserine Approved Phase 4 68-41-7 401 6234
11
Azithromycin Approved Phase 4 83905-01-5 55185 447043
12
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
14
Belladonna Approved, Experimental Phase 4
15
Methylene blue Approved, Investigational Phase 4 61-73-4
16
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
17
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
18
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
19
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
20
Norfloxacin Approved Phase 4 70458-96-7 4539
21
Sodium citrate Approved, Investigational Phase 4 68-04-2
22
Fosfomycin Approved Phase 4 23155-02-4 446987
23
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
24
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
25
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
26
Cefoxitin Approved Phase 4 35607-66-0 441199
27
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
28
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
29
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
30
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
31
BCG vaccine Investigational Phase 4
32 Pharmaceutical Solutions Phase 4
33 Gentamicins Phase 4
34 Solifenacin succinate Phase 4 242478-38-2
35 Ketorolac Tromethamine Phase 4
36 Mandelic Acids Phase 4
37 Muscarinic Antagonists Phase 4
38 Parasympatholytics Phase 4
39 Narcotics Phase 4
40 Analgesics, Opioid Phase 4
41 Adrenergic alpha-2 Receptor Agonists Phase 4
42 Amdinocillin Pivoxil Phase 4
43 Opiate Alkaloids Phase 4
44 Oxytocics Phase 4
45 Adrenergic Agents Phase 4
46 Anti-Infective Agents, Local Phase 4
47 Acriflavine Phase 4
48 Contraceptives, Oral Phase 4
49 Contraceptive Agents Phase 4
50 Contraceptives, Oral, Combined Phase 4

Interventional clinical trials:

(show top 50) (show all 339)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Solifenacin vs Levofloxacin vs Lornoxicam for Management of Intravesical Instillation of Bacillus Calmette-Guerin (BCG) Side Effects A Single Blinded Randomised Controlled Study Unknown status NCT03038321 Phase 4 sofenacin;Tavanic;Xefo
3 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
4 Randomised Clinical Trial Comparing Fosfomycin vs. Nitrofurantoin for Treatment of Uncomplicated Lower Urinary Tract Infection in Female Adults at Increased Risk of Antibiotic-resistant Bacterial Infection Unknown status NCT01966653 Phase 4 nitrofurantoin;fosfomycin
5 Randomized Placebo-Controlled Trial of Gentamicin Bladder Instillation for the Prevention of Urinary Tract Infection in Adults at High Risk for Cystitis Due to Intermittent Catheterization Unknown status NCT01884467 Phase 4 Gentamicin;Placebo
6 Botulinum A Toxin Intravesical Injections Versus Bladder Overdistension in the Treatment of Patients With Painful Bladder Syndrome: A Prospective Randomized Study Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
7 To Evaluate the Efficacy, Tolerability, and Safety of Intranasal Ketorolac Tromethamine (Sprix) as an Option for Acute (up to 5 Days) Pain Management Adult Interstitial Cystitis Patients Experiencing a Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
8 Efficacy of Combined Intravesical Therapy With Hyaluronic Acid and Chondroitin Sulphate in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract: a Multicenter, Prospective Study Completed NCT02366676 Phase 4 hyaluronic acid and chondroitin sulphate
9 A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department Completed NCT01749605 Phase 4 Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days;ciprofloxacin 250 mg BID x 3 days
10 Efficacy of Oxybutynin in Paediatric Cystitis Completed NCT03877289 Phase 4 Oxybutynin
11 The Impact of Injection Location on the Efficacy of Intravesicular Onabotulinumtoxin A in Interstitial Cystitis--Phase 4 Completed NCT02297100 Phase 4 Onabotulinumtoxin A
12 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
13 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis in Adult, Non-pregnant Women Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
14 Use of Standardized Delegation Form in Diagnosing and Treating Acute Cystitis in Primary Care Facilities. Completed NCT01132131 Phase 4
15 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository: A Randomized, Double-Blind, Placebo-Controlled Trial (ROBIN Trial) Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
16 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
17 Botox (Botulinum Toxin A) as a Treatment for Interstitial Cystitis in Women: A Randomized Placebo Controlled Trial Completed NCT00194610 Phase 4 Botox
18 Brain Imaging-based Strategies for Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
19 Ciprofloxacin for Prevention of BK Infection in Renal Transplant Recipients Completed NCT01789203 Phase 4 Ciprofloxacin;placebo
20 Detection and Treatment Benefit of Microorganism (Chlamydia Trachomatis, Mycoplasma Hominis, Ureaplasma Urealyticum) in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
21 Management of Sub-Clinical Bacteriuria in Pregnancy: A Feasibility Trial Recruiting NCT03275623 Phase 4 Antibiotic
22 Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis Recruiting NCT03379389 Phase 4 Methenamine + Methylthioninium;Methenamine + Methylthioninium + Acriflavine + Atropa belladona;Antibiotics
23 Deciphering the Hormonal and Nociceptive Mechanisms Underlying Bladder Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
24 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
25 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
26 A Prospective Cohort Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction Active, not recruiting NCT03199534 Phase 4 Botulinum toxin A 50u;Botulinum toxin A 100u;Botulinum toxin A 150u
27 Non-antimicrobial Alternative in Prophylaxis of Recurrent Urinary Tract Infections: a Prospective, Randomised-controlled, Double-blinded, Multicentre Study Not yet recruiting NCT04095572 Phase 4
28 Noroxin Efficacy and Safety Trial Not yet recruiting NCT03506256 Phase 4 Norfloxacin 400 MG
29 The Effects of Sequential Mitomycin and Bacillus Calmette-Guérin Treatment Versus Bacillus Calmette-Guérin Monotherapy in Patients With High Risk Non-Muscle Invasive Bladder Cancer Not yet recruiting NCT03790384 Phase 4 Mitomycin
30 Examining the Effects of Ketamine Treatment on Synaptic Plasticity in Depression Using PET Imaging Not yet recruiting NCT04091971 Phase 4 Ketamine
31 The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing Due to New Episodes of Urinary Tract Infections (UTI) in Elderly Women With Recurrent UTI - a Triple- Blinded, Randomized Placebo-controlled Phase IV Study Not yet recruiting NCT04077580 Phase 4 Methenamine Hippurate 1000 MG
32 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Evaluation of the Efficacy and Tolerability of Two Different Doses of ELMIRON for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
33 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
34 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
35 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective, Randomised,Placebo-controlled, Double-blind Study Terminated NCT01879930 Phase 4 doxycycline;placebo
36 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
37 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
38 Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting. A Randomized, Double Blind Trial Terminated NCT01039545 Phase 4 Diclofenac;Norfloxacin
39 Nitrofurantoin Macrocrystals 3 Days Vs. 7 Days in the Treatment of Women With Uncomplicated Cystitis Withdrawn NCT00361998 Phase 4 NITROFURANTOIN MACROCRYSTALS
40 Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL) Producing and AmpC Hyperproducing Enterobacteriaceae in United Kingdom Withdrawn NCT01543347 Phase 4 Temocillin
41 A Double-Blind, Randomized Study of Puncturing Versus Non-Puncturing Acupuncture for the Treatment of Interstitial Cystitis Symptoms Unknown status NCT00094874 Phase 3
42 Phase III Randomized Trial of Comparing CCRT vs. RT Alone for Cervical Cancer Patients Primarily Treated by Radiotherapy and With Clinically Defined Good-prognosis Unknown status NCT00846508 Phase 3 Cisplatin
43 Randomized Comparison of Cyclophosphamide Versus Fludarabine in Addition to Anti-thymocyte Globulin for the Conditioning Therapy in Allogeneic Hematopoietic Cell Transplantation for Adult Acquired Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
44 An Investigator Initiated, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Humira® (Adalimumab) For The Treatment of Interstitial Cystitis(IC) Completed NCT01295814 Phase 3 Adalimumab
45 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
46 Explorative Study on the Use of Omalizumab in Patients Suffering From Interstitial Cystitis/Painful Bladder Syndrome Completed NCT01294878 Phase 3 omalizumab
47 Multicentre, Prospective, Comparative, Randomized, Double-blind, Double-dummy Study to Assess the Efficacy and Safety of Cefditoren Pivoxil vs. Ciprofloxacin in Uncomplicated Acute Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
48 A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients Completed NCT00124306 Phase 3 Amitriptyline
49 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
50 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Completed NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carboprost
Ciprofloxacin
Mesna
Methenamine
methenamine hippurate
methenamine mandelate
METHENAMINE SULFOSALICYLATE

Cochrane evidence based reviews: cystitis

Genetic Tests for Cystitis

Anatomical Context for Cystitis

MalaCards organs/tissues related to Cystitis:

40
Prostate, Bone, Bone Marrow, Kidney, Testes, T Cells, Spinal Cord

Publications for Cystitis

Articles related to Cystitis:

(show top 50) (show all 10976)
# Title Authors PMID Year
1
Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. 54 61
19996110 2010
2
Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. 54 61
16500917 2006
3
GAP-43 immunoreactivity of subepithelial and detrusor muscle nerve fibres in patients with refractory idiopathic detrusor overactivity. 54 61
15924356 2005
4
Potential therapeutic targets for neurokinin-1 receptor antagonists. 54 61
15155133 2004
5
Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. 54 61
10702392 2000
6
Increased expression of growth-associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced cystitis. 54 61
10536274 1999
7
[Evaluation of N-acetyl-beta glucosaminidase in upper and lower urinary tract infections in childhood. Clinical study of 168 children]. 54 61
9064498 1996
8
Tamm-Horsfall protein in bladder tissue. Morphologic spectrum and clinical significance. 54 61
8179076 1994
9
Urinary N-acetyl-beta-glucosaminidase and the selection of children for radiologic evaluation after urinary tract infection. 54 61
2371096 1990
10
The effect of Seidlitzia rosmarinus (eshnan) on the prevention of recurrent cystitis in women of reproductive age: A randomized, controlled, clinical trial. 61
31680378 2020
11
Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. 61
31869244 2020
12
Current and Future Directions of Stem Cell Therapy for Bladder Dysfunction. 61
31758372 2020
13
Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis. 61
32030913 2020
14
Effect of Vaginal Lactobacillus Species on Escherichia coli Growth. 61
31990804 2020
15
Translational aspects of Nuclear Factor - kappa B and its modulation by thalidomide on early and late radiation sequelae in urinary bladder dysfunction. 61
32035188 2020
16
Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients-Results of a Spanish multicenter cohort. 61
31550408 2020
17
Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. 61
31522241 2020
18
Engineering Yarrowia lipolytica for Enhanced Production of Arbutin. 61
31903751 2020
19
Does clinical validation and the implementation of new models of outpatient service delivery have the potential to reduce waiting lists? A pilot study in Letterkenny University Hospital. 61
32030622 2020
20
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study. 61
31682968 2020
21
Impact of extended infusional mesna prophylaxis on the incidence of BK viruria and hemorrhagic cystitis following post-transplantation cyclophosphamide and CTLA4Ig-based haploidentical transplantation. 61
32025839 2020
22
A study protocol of vaginal laser therapy in gynecological cancer survivors. 61
31474161 2020
23
Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1. 61
31790304 2020
24
Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS). 61
31028455 2020
25
Long noncoding RNA (MEG3) in urinal exosomes functions as a biomarker for the diagnosis of Hunner-type interstitial cystitis (HIC). 61
31595563 2020
26
Re: A Culture-Independent Analysis of the Microbiota of Female Interstitial Cystitis/Bladder Pain Syndrome Participants in the MAPP Research Network. 61
31721675 2020
27
The devil is in the details: observational study finds better outcomes for uncomplicated cystitis treated with fluoroquinolones. 61
31968271 2020
28
Antibiotic Prescribing in New York State Medicare Part B Beneficiaries Diagnosed With Cystitis Between 2016 and 2017. 61
31988975 2020
29
Two Case Reports of Integrated Management of Antibiotic-Resistant Urinary Tract Infection. 61
31958866 2020
30
Evaluation of the draft guidelines proposed by EMA and FDA for the clinical diagnosis of acute uncomplicated cystitis in women. 61
31004204 2020
31
[Efficacy of combined antibacterial-prebiotic therapy in combination with D-mannose in women with uncomplicated lower urinary tract infection]. 61
32003165 2020
32
Urinary microbiome in uncomplicated and interstitial cystitis: is there any similarity? 61
32006175 2020
33
Individualized Homeopathic Treatment in Women with Recurrent Cystitis: A Retrospective Case Series. 61
31945769 2020
34
Glandular-type inverted papilloma of urinary bladder - Report of a unique case with immunohistochemistry. 61
32031131 2020
35
Novel 3D organotypic urothelial cell culture model for identification of new therapeutic approaches in urological infections. 61
31986366 2020
36
Prevalence and risk factors of feline lower urinary tract disease in Chiang Mai, Thailand. 61
31932653 2020
37
Postmortem urinary tract changes in cats with urethral obstruction. 61
31989774 2020
38
ErbB2 Copy Number Aberration in Canine Urothelial Carcinoma Detected by a Digital Polymerase Chain Reaction Assay. 61
31640537 2020
39
[Focused Abdominal Ultrasound in Emergency, Perioperative and Intensive Care Medicine]. 61
31958858 2020
40
Opioid prescription use in patients with interstitial cystitis. 61
31980841 2020
41
Bioinformatics analysis of the Hub genes and key pathways of interstitial cystitis pathogenesis. 61
31663162 2020
42
Dramatically deteriorated quality of life in men with prostatitis-like symptoms. 61
31090261 2020
43
BK virus nephropathy without haemorrhagic cystitis following bone marrow transplantation. 61
31621066 2020
44
Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy. 61
31729056 2020
45
High-definition ultrasound characterization of acute cyclophosphamide-induced cystitis in the mouse. 61
31942466 2020
46
Practitioner Education and Feedback to Decrease Ciprofloxacin Prescriptions in Patients with Acute Uncomplicated Cystitis. 61
31905331 2020
47
Concurrent urinary and bowel diversion: Surgical modification with sigmoid colon that avoids a bowel anastomosis. 61
31851467 2020
48
Low incidence of hemorrhagic cystitis following ex vivo T-cell depleted haploidentical hematopoietic cell transplantation in children. 61
31527820 2020
49
Effects and long-term follow-up of using umbilical cord blood-derived mesenchymal stromal cells in pediatric patients with severe BK virus-associated late-onset hemorrhagic cystitis after unrelated cord blood transplantation. 61
31944495 2020
50
Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. 61
30963398 2020

Variations for Cystitis

Expression for Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for Cystitis

Pathways related to Cystitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 VIM TP53 TNF NGF IL6 IL4
2
Show member pathways
13.57 TP53 TNF NGF IL6 IL4 IL2
3
Show member pathways
13.44 TP53 TNF TLR4 NGF IL6 IL4
4
Show member pathways
13.39 VIM TP53 TNF IL6 IL4 IL2
5
Show member pathways
13.35 TRPV1 P2RX3 NGF IL6 IL2 HBEGF
6
Show member pathways
13.33 TNF NGF IL6 IL4 IL2 HBEGF
7
Show member pathways
13.24 TP53 TNF TLR4 IL4 IL2 HBEGF
8
Show member pathways
13.13 TP53 TNF TLR4 KNG1 IL6 IL2
9
Show member pathways
13.09 TP53 NGF IL6 IL2 HBEGF EGF
10
Show member pathways
13.08 NGF IL6 IL4 IL2 HBEGF EGF
11
Show member pathways
12.97 TP53 TNF TLR4 NGF IL6 IL4
12
Show member pathways
12.88 VIM TNF IL6 IL4 IL2 CXCL8
13 12.85 TP53 KNG1 IL6 IL4 IL2 EGF
14
Show member pathways
12.83 VIM TP53 TNF TLR4 IL6 IL2
15
Show member pathways
12.74 TNF TLR4 NGF IL6 IL2 EGF
16
Show member pathways
12.63 TNF TLR4 IL6 IL4 IL2
17
Show member pathways
12.58 VIM TNF TLR4 IL6 IL4 IL2
18 12.4 TP53 TNF TLR4 CXCL8
19 12.36 TP53 TNF IL6 IL2
20
Show member pathways
12.36 TNF IL6 IL4 CXCL8
21
Show member pathways
12.36 TNF IL6 IL2 CXCL8
22
Show member pathways
12.36 IL6 IL4 IL2 EGF
23
Show member pathways
12.36 TP53 TNF TLR4 IL6 CXCL8
24
Show member pathways
12.33 TP53 TNF IL6 IL4 IL2 CRP
25 12.32 TP53 TNF TLR4 HBEGF
26 12.32 TNF TLR4 IL6 CXCL8
27
Show member pathways
12.28 TNF TLR4 IL6 CXCL8
28 12.26 TNF TLR4 IL6 CXCL8
29 12.23 TP53 TNF TLR4 IL6 EGF
30
Show member pathways
12.22 TNF TLR4 IL6 IL4 CXCL8
31
Show member pathways
12.1 TNF TLR4 IL6 IL2
32 12.09 TNF TACR1 TAC1 NGF IL6 CXCL8
33
Show member pathways
12.08 TNF TLR4 IL6 IL4
34 12.03 TNF IL6 IL4 IL2
35 12.02 TNF TLR4 IL6 IL2 CXCL8
36 11.96 TNF TLR4 IL6 CXCL8
37 11.92 TNF TLR4 IL6 CXCL8
38 11.82 TNF TLR4 IL6 CXCL8
39 11.81 TLR4 IL6 CXCL8
40 11.81 TNF IL4 IL2
41
Show member pathways
11.81 TNF IL4 IL2 CXCL8
42 11.8 VIM NGF EGF
43 11.79 TP53 IL6 IL4 IL2 CXCL8
44 11.78 TNF IL6 IL4 IL2
45 11.77 TNF IL6 IL2
46
Show member pathways
11.77 TP53 TNF NGF IL6 IL4 IL2
47
Show member pathways
11.72 TNF IL6 IL2 CXCL8
48 11.7 IL6 HBEGF CXCL8
49 11.69 UPK3A TP53 HBEGF EGF CXCL8
50 11.69 VIM TP53 TNF IL6 IL4 CXCL8

GO Terms for Cystitis

Cellular components related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 VIM UPK3A UPK1A UMOD TRPV1 TNF
2 cell GO:0005623 9.76 TRPV1 TP53 TACR1 TAC1 P2RX3 KNG1
3 extracellular region GO:0005576 9.73 UMOD TNF TAC1 NGF KNG1 IL6
4 extracellular space GO:0005615 9.36 TNF TAC1 NGF KNG1 IL6 IL4
5 apical plasma membrane urothelial plaque GO:0120001 9.26 UPK3A UPK1A

Biological processes related to Cystitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.01 UMOD TP53 NGF IL6 CXCL8
2 immune response GO:0006955 9.99 TNF TLR4 IL6 IL4 IL2 CXCL8
3 positive regulation of apoptotic process GO:0043065 9.91 TRPV1 TP53 TNF NGF KNG1 IL6
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 TP53 IL6 HBEGF EGF
5 positive regulation of T cell proliferation GO:0042102 9.77 IL6 IL4 IL2
6 positive regulation of interleukin-6 production GO:0032755 9.77 TNF TLR4 IL6
7 cellular response to lipopolysaccharide GO:0071222 9.77 VIM TNF TLR4 IL6 CXCL8
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.76 TNF IL6 HBEGF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 TRPV1 TNF TLR4
10 positive regulation of interferon-gamma production GO:0032729 9.72 TNF TLR4 IL2
11 positive regulation of cytosolic calcium ion concentration GO:0007204 9.72 TRPV1 TACR1 TAC1 KNG1 IL2
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IL6 IL4 IL2
13 positive regulation of B cell proliferation GO:0030890 9.7 TLR4 IL4 IL2
14 cytokine-mediated signaling pathway GO:0019221 9.7 VIM TP53 TNF IL6 IL4 IL2
15 response to pain GO:0048265 9.65 TRPV1 TACR1 TAC1
16 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 IL4 IL2
17 positive regulation of chemokine production GO:0032722 9.63 TNF TLR4 IL6
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 TLR4 IL4
19 response to salt stress GO:0009651 9.62 TP53 TNF
20 tachykinin receptor signaling pathway GO:0007217 9.61 TACR1 TAC1
21 positive regulation of gene expression GO:0010628 9.61 VIM TP53 TNF TLR4 NGF IL6
22 positive regulation of lymphocyte proliferation GO:0050671 9.58 TLR4 TAC1
23 urinary bladder smooth muscle contraction GO:0014832 9.57 TRPV1 P2RX3
24 detection of abiotic stimulus GO:0009582 9.54 TACR1 TAC1
25 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
26 inflammatory response GO:0006954 9.28 TRPV1 TNF TLR4 TACR1 TAC1 KNG1

Molecular functions related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IL4 IL2 CXCL8
2 growth factor activity GO:0008083 9.1 NGF IL6 IL4 IL2 HBEGF EGF

Sources for Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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