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MCID: CYS018
MIFTS: 59

Cystitis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cystitis

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MalaCards integrated aliases for Cystitis:

Name: Cystitis 12 54 44 15 62 17 71 32
Infective Cystitis 71

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1679
ICD9CM 34 595
MeSH 44 D003556
NCIt 50 C26738
SNOMED-CT 67 38822007
ICD10 32 N30 N30.9
UMLS 71 C0010692 C0600041
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Summaries for Cystitis

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PubMed Health : 62 About cystitis: Many women know the symptoms of cystitis (a urinary tract infection, or UTI) only too well: frequent trips to the bathroom and a stinging and burning sensation when passing urine. Although these symptoms are often very unpleasant, there are effective treatments. Uncomplicated cystitis usually clears up without any problems. Unfortunately, there is no sure-fire way to reliably prevent cystitis. And a lot of the common strategies women may use in day-to-day life have not yet been scientifically tested. This article is about acute cystitis – a bladder infection often also referred to as a urinary tract infection (UTI). It is not about chronic bladder problems such as interstitial cystitis. It also doesn't include information about treating cystitis in pregnant women.

MalaCards based summary : Cystitis, also known as infective cystitis, is related to hemorrhagic cystitis and interstitial cystitis. An important gene associated with Cystitis is UMOD (Uromodulin), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and prostate, and related phenotypes are behavior/neurological and homeostasis/metabolism

Disease Ontology : 12 A bladder disease that is characterized by inflammation of the bladder.

Wikipedia : 74 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

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Related Diseases for Cystitis

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Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 984)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic cystitis 33.0 TNF TLR4 IL2
2 interstitial cystitis 32.5 UPK3A UPK1A UMOD TRPV1 TACR1 TAC1
3 urinary tract infection 32.4 UMOD TLR4 CRP
4 bladder tuberculosis 32.4 UPK3A HBEGF
5 acute cystitis 32.3 VIM UPK3A UPK1A UMOD TNF TLR4
6 chronic cystitis 32.2 UPK3A UPK1A TRPV1 TLR4 TAC1 P2RX3
7 urethral syndrome 32.1 TNF TAC1 P2RX3 NGF IL6 CXCL8
8 pyelonephritis 31.5 UMOD TNF TLR4 IL6 CXCL8 CRP
9 bacteriuria 31.4 UMOD TLR4 IL6 CXCL8 CRP
10 hydronephrosis 31.4 UPK3A IL6 EGF CXCL8 CRP
11 graft-versus-host disease 31.4 TNF IL6 IL2
12 pyuria 31.4 UPK3A IL6 CXCL8 CRP
13 prostatitis 31.3 TP53 TNF IL6 IL4 IL2 CXCL8
14 acute graft versus host disease 31.3 TNF IL4 IL2
15 fibromyalgia 31.2 TNF TACR1 NGF IL6 CXCL8 CRP
16 urinary tract obstruction 31.1 UPK3A UMOD HBEGF EGF CRP
17 acute pyelonephritis 31.1 IL6 CXCL8 CRP
18 urethritis 31.0 TNF TLR4 IL6 CXCL8 CRP
19 vesicoureteral reflux 1 31.0 UPK3A UPK1A UMOD CXCL8 CRP
20 bladder cancer 31.0 UPK3A UPK1A TP53 TNF IL2 HBEGF
21 vaginitis 31.0 TNF IL6 CXCL8
22 bacterial infectious disease 30.9 TNF TLR4 IL6 CXCL8 CRP
23 acute kidney failure 30.9 UMOD KNG1 EGF
24 chronic fatigue syndrome 30.8 TNF TLR4 IL6 IL4 IL2 CXCL8
25 allergic disease 30.8 TNF TLR4 IL6 IL4 IL2
26 peritonitis 30.8 TNF TLR4 IL6 IL4 CXCL8 CRP
27 irritable bowel syndrome 30.8 TRPV1 TNF TLR4 TAC1 NGF IL6
28 ileus 30.8 TNF IL6 CRP
29 vaginal discharge 30.8 TNF IL6 CXCL8 CRP
30 pyelitis 30.7 UPK3A UPK1A UMOD TNF TLR4 IL6
31 cholecystitis 30.7 TP53 TLR4 EGF
32 neurogenic bladder 30.7 UPK3A UPK1A TRPV1 TACR1 TAC1 P2RX3
33 chlamydia 30.7 TNF TLR4 IL6 IL4 CXCL8 CRP
34 autoimmune disease 30.7 TNF IL6 IL4 IL2 CXCL8 CRP
35 systemic lupus erythematosus 30.6 TP53 TNF TLR4 IL6 IL4 IL2
36 constipation 30.6 VIM TACR1 TAC1 IL6 CRP
37 aplastic anemia 30.6 TP53 TNF IL6 IL4 IL2 CXCL8
38 toxic shock syndrome 30.6 TNF TLR4 IL6 IL4 IL2 CXCL8
39 chronic pyelonephritis 30.6 UMOD TLR4 CRP
40 purpura 30.5 TNF IL6 IL4 CRP
41 allergic rhinitis 30.5 NGF KNG1 IL4 CXCL8
42 gastroenteritis 30.5 TNF IL6 IL4 CXCL8 CRP
43 disease by infectious agent 30.5 TNF TLR4 IL6 IL4 IL2 CRP
44 conjunctivitis 30.5 TNF IL6 IL4 IL2 CXCL8
45 rhinitis 30.5 TNF NGF KNG1 IL6 IL4 CXCL8
46 polyneuropathy 30.5 TNF NGF IL6 CRP
47 gastritis 30.5 TP53 TNF TLR4 IL6 CXCL8
48 schistosomiasis 30.5 TP53 TNF IL4 IL2
49 exanthem 30.5 TNF IL6 IL2 CXCL8 CRP
50 covid-19 30.5 TLR4 IL6 IL4 CXCL8

Comorbidity relations with Cystitis via Phenotypic Disease Network (PDN): (show all 29)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bladder Cancer Bladder Neck Obstruction
Bronchitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Neurogenic Bladder
Osteoporosis Paralytic Ileus
Parkinson Disease, Late-Onset Prostatic Hypertrophy
Protein-Energy Malnutrition Pyelonephritis
Radiation Cystitis Schizophreniform Disorder
Transient Cerebral Ischemia Urethral Stricture
Urethritis

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to Cystitis
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Symptoms & Phenotypes for Cystitis

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MGI Mouse Phenotypes related to Cystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 HBEGF IL2 IL6 KNG1 NGF P2RX3
2 homeostasis/metabolism MP:0005376 10.22 CRP HBEGF IL2 IL4 IL6 KNG1
3 cardiovascular system MP:0005385 10.21 CRP HBEGF IL2 IL6 NGF P2RX3
4 immune system MP:0005387 10.07 CRP EGF IL2 IL4 IL6 P2RX3
5 integument MP:0010771 9.93 EGF HBEGF IL4 IL6 NGF P2RX3
6 renal/urinary system MP:0005367 9.56 IL4 IL6 TAC1 TLR4 TP53 TRPV1
7 respiratory system MP:0005388 9.32 HBEGF IL2 IL4 IL6 P2RX3 TACR1
Sources

Drugs & Therapeutics for Cystitis

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PubMed Health treatment related to Cystitis: 62

For many women, cystitis is a one-time unpleasant problem. In others, it may keep coming back. Antibiotics have been proven to effectively relieve acute cystitis , and they usually work quickly. There are also some home remedies that may help, like drinking plenty of fluids or applying heat. Herbal products are available too.

Drugs for Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 4 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3
Fosfomycin Approved Phase 4 23155-02-4 446987
4
BCG vaccine Approved, Investigational Phase 4
5
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
6
Sulfamethoxazole Approved Phase 4 723-46-6 5329
7
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
8
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
9
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
10
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
11
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
12
Cefazolin Approved Phase 4 25953-19-9 656510 33255
13
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
14
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
15
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
16
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
17
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
18
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
19
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
20
Ibuprofen Approved Phase 4 15687-27-1 3672
21
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
22
Morphine Approved, Investigational Phase 4 57-27-2 5288826
23
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
24
Polyestradiol phosphate Approved Phase 4 28014-46-2
25
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
26
Ferrous fumarate Approved Phase 4 141-01-5
27
Norethindrone Approved Phase 4 68-22-4 6230
28
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
29
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
30
Methylene blue Approved, Investigational Phase 4 61-73-4
31
Belladonna Approved, Experimental Phase 4
32
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
33
Ethanol Approved Phase 4 64-17-5 702
34
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
35
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
36
Acriflavine Experimental Phase 4 65589-70-0
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 Gentamicins Phase 4
39 Solifenacin succinate Phase 4 242478-38-2
40 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
41 Parasympatholytics Phase 4
42 cefuroxime axetil Phase 4
43 Amoxicillin-Potassium Clavulanate Combination Phase 4
44 Cephradine Phase 4
45 Cholinergic Agents Phase 4
46 Cholinergic Antagonists Phase 4
47 Muscarinic Antagonists Phase 4
48 cephalothin Phase 4
49 Adrenergic Agonists Phase 4
50 Protective Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 236)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Randomized Placebo-Controlled Trial of Gentamicin Bladder Instillation for the Prevention of Urinary Tract Infection in Adults at High Risk for Cystitis Due to Intermittent Catheterization Unknown status NCT01884467 Phase 4 Gentamicin;Placebo
3 Randomised Clinical Trial Comparing Fosfomycin vs. Nitrofurantoin for Treatment of Uncomplicated Lower Urinary Tract Infection in Female Adults at Increased Risk of Antibiotic-resistant Bacterial Infection Unknown status NCT01966653 Phase 4 nitrofurantoin;fosfomycin
4 Solifenacin vs Levofloxacin vs Lornoxicam for Management of Intravesical Instillation of Bacillus Calmette-Guerin (BCG) Side Effects A Single Blinded Randomised Controlled Study Unknown status NCT03038321 Phase 4 sofenacin;Tavanic;Xefo
5 Botulinum A Toxin Intravesical Injections Versus Bladder Overdistension in the Treatment of Patients With Painful Bladder Syndrome: A Prospective Randomized Study Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
6 Efficacy of Oxybutynin in Paediatric Cystitis Completed NCT03877289 Phase 4 Oxybutynin;Antibiotics
7 To Evaluate the Efficacy, Tolerability, and Safety of Intranasal Ketorolac Tromethamine (Sprix) as an Option for Acute (up to 5 Days) Pain Management Adult Interstitial Cystitis Patients Experiencing a Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
8 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
9 Botox (Botulinum Toxin A) as a Treatment for Interstitial Cystitis in Women: A Randomized Placebo Controlled Trial Completed NCT00194610 Phase 4 Botox
10 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
11 The Impact of Injection Location on the Efficacy of Intravesicular Onabotulinumtoxin A in Interstitial Cystitis--Phase 4 Completed NCT02297100 Phase 4 Onabotulinumtoxin A
12 Use of Standardized Delegation Form in Diagnosing and Treating Acute Cystitis in Primary Care Facilities. Completed NCT01132131 Phase 4
13 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis in Adult, Non-pregnant Women Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
14 A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department Completed NCT01749605 Phase 4 Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days;ciprofloxacin 250 mg BID x 3 days
15 Efficacy of Combined Intravesical Therapy With Hyaluronic Acid and Chondroitin Sulphate in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract: a Multicenter, Prospective Study Completed NCT02366676 Phase 4 hyaluronic acid and chondroitin sulphate
16 Management of Sub-Clinical Bacteriuria in Pregnancy: A Feasibility Trial Completed NCT03275623 Phase 4 Antibiotic
17 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository: A Randomized, Double-Blind, Placebo-Controlled Trial (ROBIN Trial) Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
18 Deciphering the Hormonal and Nociceptive Mechanisms Underlying Bladder Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
19 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
20 Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis Active, not recruiting NCT03379389 Phase 4 Methenamine + Methylthioninium;Methenamine + Methylthioninium + Acriflavine + Atropa belladona;Antibiotics
21 IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder Syndrome a Randomized Placebo-controlled Prospective Trial Not yet recruiting NCT04313972 Phase 4 low-dose naltrexone;Placebo oral tablet
22 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
23 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Evaluation of the Efficacy and Tolerability of Two Different Doses of ELMIRON for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
24 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
25 Prospective Randomised Trial Comparing Intravesical Chondroitin Sulphate 2% and DMSO in the Treatment of Painful Bladder Syndrome/ Interstitial Cystitis Terminated NCT04268810 Phase 4
26 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective, Randomised,Placebo-controlled, Double-blind Study Terminated NCT01879930 Phase 4 doxycycline;placebo
27 Nitrofurantoin Macrocrystals 3 Days Vs. 7 Days in the Treatment of Women With Uncomplicated Cystitis Withdrawn NCT00361998 Phase 4 NITROFURANTOIN MACROCRYSTALS
28 A Double-Blind, Randomized Study of Puncturing Versus Non-Puncturing Acupuncture for the Treatment of Interstitial Cystitis Symptoms Unknown status NCT00094874 Phase 3
29 The LEADERSHIP 301 Trial: A 12-Week, Randomized, Multi-Center, Double-Blind, Placebo-Controlled, 3-Arm, Parallel-Group, Phase 3 Trial to Evaluate the Efficacy and Safety of 2 Doses of AQX-1125 Targeting the Src Homology 2-containing Inositol-5'-Phosphatase 1 (SHIP1) Pathway in Subjects With Interstitial Cystitis/Bladder Pain Syndrome Followed by an Extension Period Unknown status NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
30 Recurrent Urinary Tract Infections in Adult Women: a Pilot Study With Oral D Mannose Completed NCT01808755 Phase 3 trimethoprim/sulfamethoxazole
31 A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients Completed NCT00124306 Phase 3 Amitriptyline
32 Explorative Study on the Use of Omalizumab in Patients Suffering From Interstitial Cystitis/Painful Bladder Syndrome Completed NCT01294878 Phase 3 omalizumab
33 Randomized Controlled Trial Comparing Two Different Bladder Instillation Treatments for Interstitial Cystitis/Bladder Pain Syndrome Completed NCT03463915 Phase 3 Bladder instillation WITH triamcinolone acetonide;Bladder instillation WITHOUT triamcinolone acetonide
34 An Investigator Initiated, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Humira® (Adalimumab) For The Treatment of Interstitial Cystitis(IC) Completed NCT01295814 Phase 3 Adalimumab
35 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
36 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
37 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Completed NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen
38 Multicentre, Prospective, Comparative, Randomized, Double-blind, Double-dummy Study to Assess the Efficacy and Safety of Cefditoren Pivoxil vs. Ciprofloxacin in Uncomplicated Acute Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
39 Multicenter, Randomized, Double-blind, Placebo-controlled Parallel Group Trial to Evaluate the Efficacy and Tolerability of a Phytotherapy Combination (Aqualibra) in Patients With Uncomplicated Cystitis Completed NCT04032574 Phase 3
40 Upfront Autologous Hematopoietic Stem Cell Transplantation Versus Immunosuppressive Medication in Early Diffuse Cutaneous Systemic Sclerosis: an International Multicentre, Open-label, Randomized Con-trolled Trial Recruiting NCT04464434 Phase 3
41 A Phase III, Randomized, Multicenter, Parallel-Group, Double-Blind, Double-Dummy Study in Adolescent and Adult Female Participants Comparing the Efficacy and Safety of Gepotidacin to Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infection (Acute Cystitis) Recruiting NCT04187144 Phase 3 Gepotidacin;Placebo matching nitrofurantoin;Nitrofurantoin;Placebo matching gepotidacin
42 A Phase III, Randomized, Multicenter, Parallel-Group, Double-Blind, Double-Dummy Study in Adolescent and Adult Female Participants Comparing the Efficacy and Safety of Gepotidacin to Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infection (Acute Cystitis) Recruiting NCT04020341 Phase 3 Gepotidacin;Placebo matching nitrofurantoin;Nitrofurantoin;Placebo matching gepotidacin
43 Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR105) for the Treatment of Patients With Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant (HCT) Recruiting NCT04390113 Phase 3
44 A Pilot Study of the Effects of Mirabegron on Symptoms in Patients With Interstitial Cystitis Terminated NCT02787083 Phase 3 Mirabegron;Placebo
45 A Randomized Multicenter Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of Mycophenolate Mofetil (CellCept) for the Treatment of Refractory Interstitial Cystitis (IC) Terminated NCT00451867 Phase 3 Mycophenolate Mofetil;Mycofenolate Mofetil (MMF);Placebo
46 Randomized Trial of Busulfan or Total Body Irradiation Conditioning Regimens for Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
47 Randomized Study of Different Non-myeloablative Conditioning Regimens With Hematopoietic Stem Cell Support in Patients With Scleroderma (Autologous Systemic Sclerosis Immune Suppression Trial - II ASSIST-IIb) Terminated NCT01445821 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;Filgrastim;Fludarabine
48 Maximizing Outcome of Multiple Sclerosis Transplantation: "MOST" Trial Terminated NCT03342638 Phase 3 Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF
49 A Phase III Non-Inferiority Open-label Multicenter Randomized Clinical Trial to Compare CEPHALOSPORIN to NORFLOXACIN in the Treatment of Acute Cystitis Withdrawn NCT01527019 Phase 3 Norfloxacin;Cephalosporins;Cephalosporins
50 Randomized Controlled Trial for Efficacy of Botulinum Toxin Type A in Treatment of Patients Suffering Bladder Pain Syndrome/Interstitial Cystitis With Hunners' Lesions Unknown status NCT01437579 Phase 2

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Carboprost
Ciprofloxacin
Mesna
Methenamine
methenamine hippurate
methenamine mandelate
METHENAMINE SULFOSALICYLATE

Cochrane evidence based reviews: cystitis

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Genetic Tests for Cystitis

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Anatomical Context for Cystitis

About this section

MalaCards organs/tissues related to Cystitis:

40
Bone Marrow, Kidney, Prostate, Cervix, Spinal Cord, Breast, Brain
Sources

Publications for Cystitis

About this section

Articles related to Cystitis:

(show top 50) (show all 11458)
# Title Authors PMID Year
1
Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. 61 54
19996110 2010
2
Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. 54 61
16500917 2006
3
GAP-43 immunoreactivity of subepithelial and detrusor muscle nerve fibres in patients with refractory idiopathic detrusor overactivity. 61 54
15924356 2005
4
Potential therapeutic targets for neurokinin-1 receptor antagonists. 61 54
15155133 2004
5
Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. 61 54
10702392 2000
6
Increased expression of growth-associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced cystitis. 61 54
10536274 1999
7
[Evaluation of N-acetyl-beta glucosaminidase in upper and lower urinary tract infections in childhood. Clinical study of 168 children]. 61 54
9064498 1996
8
Tamm-Horsfall protein in bladder tissue. Morphologic spectrum and clinical significance. 54 61
8179076 1994
9
Urinary N-acetyl-beta-glucosaminidase and the selection of children for radiologic evaluation after urinary tract infection. 54 61
2371096 1990
10
A mixed-method simulated patient approach to explore implicit bias in health care: A feasibility study in community pharmacy. 61
32417071 2021
11
Safety evaluation of the canine osteosarcoma vaccine, live Listeria vector. 61
32729979 2021
12
Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study. 61
33146980 2021
13
Editorial Comment: Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study. 61
33284534 2021
14
Re: Systemic Therapy for Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC): Systematic Review of Published Trials in the Last 5 Years. 61
33257030 2021
15
Editorial Comment: Intravesical injections of platelet-rich plasma is effective and safe in treatment of interstitial cystitis refractory to conventional treatment-A prospective clinical trial. 61
33284551 2021
16
Swiss consensus recommendations on urinary tract infections in children. 61
32621135 2021
17
Comparison of deep phenotyping features of UCPPS with and without Hunner lesion: A MAPP-II Research Network Study. 61
33604963 2021
18
Prevalence of autoimmune disorders among bladder pain syndrome patients' relatives. 61
32964777 2021
19
Eosinophilic cystitis mimicking bladder cancer-considerations on the management based upon a case report and a review of the literature. 61
33576854 2021
20
Repeat Vaginal Natural Orifice Transluminal Endoscopic Surgery: A First Feasibility Study. 61
33556956 2021
21
High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study. 61
33095672 2021
22
Efficacy and safety of allogenic canine adipose tissue-derived mesenchymal stem cell therapy for insulin-dependent diabetes mellitus in four dogs: a pilot study. 61
33551441 2021
23
Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: an EMBRACE analysis. 61
33545254 2021
24
Outcome of a 980-nm diode laser coagulation in women with radiation-induced hemorrhagic cystitis: a single-center retrospective study. 61
32304002 2021
25
Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain, and voiding dysfunction: a novel animal model for Hunner-type interstitial cystitis. 61
33308017 2021
26
The association between exposure to domestic abuse in women and the development of syndromes indicating central nervous system sensitisation: a retrospective cohort study using UK primary care records. 61
33559289 2021
27
Protective and therapeutic effect of Hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with Cyclophosphamide. 61
33550762 2021
28
Downregulation of redox imbalance and iNOS/NF-ĸB/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats. 61
33333050 2021
29
Superselective Vesical Artery Embolization for Intractable Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation: A Single-Center Retrospective Study in 26 Patients. 61
33608760 2021
30
Retrospective interview-based long-term follow-up study of cats diagnosed with idiopathic cystitis in 2003-2009. 61
33541237 2021
31
Adverse Effects of Kampo Medicines. 61
33551404 2021
32
Urotherapist activities in caring for patients with pelvic floor disorders: a prospective single-center observational study. 61
33000294 2021
33
Antibiotic prescribing for adult bacteriuria and pyuria in community hospital emergency departments. 61
33326910 2021
34
Rare case of osteomyelitis caused by Gardnerella vaginalis and Streptococcus parasanguinis in a postmenopausal woman. 61
33526521 2021
35
Efficacy and safety of intravesical instillation of KRP-116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study. 61
33580603 2021
36
Lifestyle and behavioral modifications made by patients with interstitial cystitis. 61
33542405 2021
37
Long-term outcomes of ulcerative interstitial cystitis after complete transurethral resection with therapeutic hydrodistention. 61
32926313 2021
38
Beneficial effect of Bletilla striata extract solution on zymosan-induced interstitial cystitis in rat. 61
33604897 2021
39
Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis. 61
33340266 2021
40
Cannabinoids in Urology. Which Benign Conditions Might They Be Appropriate to Treat: A Systematic Review. 61
33129871 2021
41
National Patterns of Filled Prescriptions and Third-Line Treatment Utilization for Privately Insured Women With Overactive Bladder. 61
31157717 2021
42
Temporal Relationships Between Pain, Mood and Urinary Symptoms in Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Network Study. 61
33535797 2021
43
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study. 61
33602159 2021
44
Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics. 61
33538002 2021
45
Microscopic detection of bacillus Calmette-Guérin mycobacteria in bladder biopsy using fluorescence in situ hybridization: Détection microscopique des Bacilles biliés de Calmette et Guérin (BCG) dans une biopsie vésicale par hybridation in situ en fluorescence. 61
33425363 2021
46
N-glycan signature of serum immunoglobulins as a diagnostic biomarker of urothelial carcinomas. 61
33455069 2021
47
MALT Lymphoma of the Urinary Bladder Shows a Dramatic Female Predominance, Uneven Geographic Distribution, and Possible Infectious Etiology. 61
33575225 2021
48
Monotypic Plasma Cell Proliferation of Uncertain Clinical Significance Mimicking Interstitial Cystitis: An Early Lesion of MALT Lymphoma? 61
33399339 2021
49
HDR brachytherapy boost using MR-only workflow for intermediate- and high-risk prostate cancer: 8-year results of a pilot study. 61
33478906 2021
50
Lower Urinary Tract Symptoms in Prostate Cancer Patients Treated With Radiation Therapy: Past and Present. 61
33504132 2021
Sources

Variations for Cystitis

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Expression for Cystitis

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Search GEO for disease gene expression data for Cystitis.
Sources

Pathways for Cystitis

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Pathways related to Cystitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.85 VIM TP53 TNF NGF IL6 IL4
2
TGF-Beta Pathway 63
Show member pathways
 13.57 TP53 TNF NGF IL6 IL4 IL2
3
Akt Signaling 63
Show member pathways
 13.43 TP53 TNF TLR4 NGF IL6 IL4
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.39 VIM TP53 TNF IL6 IL4 IL2
5
CREB Pathway 63
Show member pathways
 13.34 TRPV1 P2RX3 NGF IL6 IL2 HBEGF
6
PAK Pathway 63
Show member pathways
 13.33 TNF NGF IL6 IL4 IL2 HBEGF
7
IL-2 Pathway 63
Show member pathways
 13.23 TP53 TNF TLR4 IL4 IL2 HBEGF
8
Phospholipase-C Pathway 63
Show member pathways
 13.09 TP53 NGF IL6 IL2 HBEGF EGF
9
p70S6K Signaling 63
Show member pathways
 13.06 NGF IL6 IL4 IL2 HBEGF EGF
10
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.04 TP53 TNF TLR4 KNG1 IL6 IL2
11
PI3K-Akt signaling pathway 36
Show member pathways
 12.97 TP53 TNF TLR4 NGF IL6 IL4
12
Allograft rejection 36 1
Show member pathways
 12.89 VIM TNF IL6 IL4 IL2 CXCL8
13
Pathways in cancer 36
12.86 TP53 KNG1 IL6 IL4 IL2 EGF
14
Measles 36
Show member pathways
 12.84 VIM TP53 TNF TLR4 IL6 IL2
15
NF-KappaB Family Pathway 63
Show member pathways
 12.75 TNF TLR4 NGF IL6 IL2 EGF
16
Th17 cell differentiation 36
Show member pathways
 12.62 TNF TLR4 IL6 IL4 IL2
17
T cell receptor signaling pathway 36
Show member pathways
 12.58 VIM TNF TLR4 IL6 IL4 IL2
18
Calcium signaling pathway 36
12.41 TACR1 P2RX3 NGF EGF
19
Human T-cell leukemia virus 1 infection 36
12.36 TP53 TNF IL6 IL2
20
IL-17 Family Signaling Pathways 64
Show member pathways
 12.36 TNF IL6 IL4 CXCL8
21
Toll Comparative Pathway 63
Show member pathways
 12.36 TP53 TNF TLR4 IL6 CXCL8
22
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.35 TNF IL6 IL2 CXCL8
23
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.33 TP53 IL6 HBEGF EGF
24
Folate Metabolism 1
Show member pathways
 12.33 TP53 TNF IL6 IL4 IL2 CRP
25
Proteoglycans in cancer 36
12.32 TP53 TNF TLR4 HBEGF
26
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.28 TNF TLR4 IL6 CXCL8
27
NOD-like receptor signaling pathway 36
12.25 TNF TLR4 IL6 CXCL8
28
Colorectal Cancer Metastasis 63
12.23 TP53 TNF TLR4 IL6 EGF
29
Bacterial infections in CF airways 23
Show member pathways
 12.22 TNF TLR4 IL6 IL4 CXCL8
30
Yersinia infection 36
12.09 TNF TLR4 IL6 IL2 CXCL8
31
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.09 TNF TACR1 TAC1 NGF IL6 CXCL8
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.04 TNF IL6 IL4 IL2
33
Amoebiasis 36
11.97 TNF TLR4 IL6 CXCL8
34
Rheumatoid arthritis 36
11.92 TNF TLR4 IL6 CXCL8
35
Th1 Differentiation Pathway 64
Show member pathways
 11.83 TNF TLR4 IL6 IL2
36
Pertussis 36
11.82 TNF TLR4 IL6 CXCL8
37
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.82 TNF IL4 IL2 CXCL8
38
Innate Lymphoid Cell Differentiation Pathways 64
11.81 TNF IL4 IL2
39
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.8 VIM NGF EGF
40
Glucocorticoid receptor regulatory network 1
11.79 TP53 IL6 IL4 IL2 CXCL8
41
Dendritic Cells Developmental Lineage Pathway 64
11.77 TNF IL6 IL2
42
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 11.77 TP53 TNF NGF IL6 IL4 IL2
43
IgA-Producing B Cells in the Intestine 64
11.75 TNF TLR4 IL6 IL4
44
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.72 TNF IL6 IL2 CXCL8
45
LPA receptor mediated events 1
11.7 IL6 HBEGF CXCL8
46
Bladder cancer 36 1
11.69 UPK3A TP53 HBEGF EGF CXCL8
47
Interleukin-4 and 13 signaling 65
11.69 VIM TP53 TNF IL6 IL4 CXCL8
48
Legionellosis 36
11.66 TNF TLR4 IL6 CXCL8
49
Hepatitis C and Hepatocellular Carcinoma 1
11.58 TP53 IL6 CXCL8
50
Malaria 36
11.58 TNF TLR4 IL6 CXCL8
Sources

GO Terms for Cystitis

About this section

Cellular components related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 VIM UPK3A UPK1A UMOD TRPV1 TNF
2 extracellular region GO:0005576 9.73 UMOD TNF TAC1 NGF KNG1 IL6
3 extracellular space GO:0005615 9.4 UMOD TNF TAC1 NGF KNG1 IL6
4 apical plasma membrane urothelial plaque GO:0120001 9.16 UPK3A UPK1A

Biological processes related to Cystitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.04 UMOD TP53 NGF IL6 CXCL8
2 immune response GO:0006955 9.99 TNF TLR4 IL6 IL4 IL2 CXCL8
3 positive regulation of apoptotic process GO:0043065 9.91 TRPV1 TP53 TNF NGF KNG1 IL6
4 apoptotic signaling pathway GO:0097190 9.83 UMOD TNF TLR4
5 positive regulation of interferon-gamma production GO:0032729 9.8 TNF TLR4 IL2
6 positive regulation of T cell proliferation GO:0042102 9.8 IL6 IL4 IL2
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 TNF IL6 HBEGF
8 positive regulation of interleukin-8 production GO:0032757 9.78 TNF TLR4 IL6
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 TP53 IL6 HBEGF EGF
10 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF TLR4 IL6
11 cellular response to lipopolysaccharide GO:0071222 9.77 VIM TNF TLR4 IL6 CXCL8
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 TRPV1 TNF TLR4
13 positive regulation of B cell proliferation GO:0030890 9.73 TLR4 IL4 IL2
14 positive regulation of chemokine production GO:0032722 9.72 TNF TLR4 IL6
15 positive regulation of cytosolic calcium ion concentration GO:0007204 9.72 TRPV1 TACR1 TAC1 KNG1 IL2
16 positive regulation of interleukin-10 production GO:0032733 9.71 TLR4 IL6 IL4
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IL6 IL4 IL2
18 microglial cell activation GO:0001774 9.7 TRPV1 TNF IL4
19 cytokine-mediated signaling pathway GO:0019221 9.7 VIM TP53 TNF IL6 IL4 IL2
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.67 TNF TLR4 IL6
21 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.66 TNF TLR4
22 response to salt stress GO:0009651 9.66 TP53 TNF
23 negative regulation of T-helper 17 cell differentiation GO:2000320 9.65 IL4 IL2
24 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IL4 IL2
25 positive regulation of gene expression GO:0010628 9.65 VIM TP53 TNF TLR4 NGF IL6
26 positive regulation of lymphocyte proliferation GO:0050671 9.64 TLR4 TAC1
27 tachykinin receptor signaling pathway GO:0007217 9.63 TACR1 TAC1
28 response to pain GO:0048265 9.63 TRPV1 TACR1 TAC1
29 vascular endothelial growth factor production GO:0010573 9.61 TNF IL6
30 positive regulation of mononuclear cell migration GO:0071677 9.59 TNF IL4
31 urinary bladder smooth muscle contraction GO:0014832 9.58 TRPV1 P2RX3
32 detection of abiotic stimulus GO:0009582 9.57 TACR1 TAC1
33 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
34 inflammatory response GO:0006954 9.32 UMOD TRPV1 TNF TLR4 TACR1 TAC1

Molecular functions related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IL4 IL2 CXCL8
2 growth factor activity GO:0008083 9.1 NGF IL6 IL4 IL2 HBEGF EGF
Sources

Sources for Cystitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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