MCID: CYS018
MIFTS: 59

Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Cystitis

MalaCards integrated aliases for Cystitis:

Name: Cystitis 12 54 43 15 62 17 71 32
Infective Cystitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1679
ICD9CM 34 595
MeSH 43 D003556
NCIt 49 C26738
SNOMED-CT 67 38822007
ICD10 32 N30 N30.9
UMLS 71 C0010692 C0600041

Summaries for Cystitis

PubMed Health : 62 About cystitis: Many women know the symptoms of cystitis (a urinary tract infection, or UTI) only too well: frequent trips to the bathroom and a stinging and burning sensation when passing urine. Although these symptoms are often very unpleasant, there are effective treatments. Uncomplicated cystitis usually clears up without any problems. Unfortunately, there is no sure-fire way to reliably prevent cystitis. And a lot of the common strategies women may use in day-to-day life have not yet been scientifically tested. This article is about acute cystitis – a bladder infection often also referred to as a urinary tract infection (UTI). It is not about chronic bladder problems such as interstitial cystitis. It also doesn't include information about treating cystitis in pregnant women.

MalaCards based summary : Cystitis, also known as infective cystitis, is related to hemorrhagic cystitis and chronic cystitis. An important gene associated with Cystitis is UMOD (Uromodulin), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Lornoxicam and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and bone marrow, and related phenotypes are behavior/neurological and homeostasis/metabolism

Disease Ontology : 12 A bladder disease that is characterized by inflammation of the bladder.

Related Diseases for Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 946)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic cystitis 35.0 TNF TLR4 IL2
2 chronic cystitis 34.5 UPK3A UPK1A TRPV1 TAC1 P2RX3 NGF
3 acute cystitis 34.4 VIM UPK3A UPK1A UMOD TNF TLR4
4 interstitial cystitis 34.3 UPK3A UPK1A UMOD TRPV1 TACR1 TAC1
5 urethral syndrome 33.4 UMOD TAC1 P2RX3 NGF IL6 CXCL8
6 pyelonephritis 31.9 UMOD TNF TLR4 IL6 CXCL8 CRP
7 prostatitis 31.9 TP53 TNF IL6 CXCL8
8 bacteriuria 31.9 UMOD TLR4 IL6 CXCL8 CRP
9 graft-versus-host disease 31.8 TNF IL6 IL2
10 hydronephrosis 31.8 UPK3A IL6 EGF CXCL8 CRP
11 pyuria 31.8 UPK3A IL6 CXCL8 CRP
12 acute graft versus host disease 31.7 TNF IL4 IL2
13 fibromyalgia 31.6 TNF TACR1 P2RX3 NGF IL6 CXCL8
14 acute pyelonephritis 31.5 IL6 CXCL8 CRP
15 urethritis 31.5 TNF TLR4 IL6 CXCL8 CRP
16 bladder cancer 31.5 UPK3A UPK1A TP53 TNF IL2 HBEGF
17 vesicoureteral reflux 1 31.4 UPK3A UPK1A UMOD CXCL8 CRP
18 urinary tract obstruction 31.4 UPK3A UMOD TNF HBEGF EGF CRP
19 neurogenic bladder 31.4 UPK3A TRPV1 TACR1 TAC1 P2RX3 NGF
20 bacterial infectious disease 31.4 TNF TLR4 IL6 CXCL8 CRP
21 autoimmune disease 31.3 TNF IL6 IL4 IL2 CXCL8 CRP
22 pyelitis 31.3 UPK1A UMOD TNF TLR4 IL6 CXCL8
23 vaginitis 31.3 TNF TLR4 IL6 CXCL8
24 chronic fatigue syndrome 31.3 TNF TLR4 IL6 IL4 IL2 CXCL8
25 acute kidney failure 31.3 UMOD KNG1 EGF
26 irritable bowel syndrome 31.2 TRPV1 TNF TLR4 TACR1 TAC1 NGF
27 vaginal discharge 31.2 TNF IL6 CXCL8 CRP
28 peritonitis 31.2 TNF TLR4 IL6 IL4 CXCL8 CRP
29 systemic lupus erythematosus 31.1 TP53 TNF TLR4 IL6 IL4 IL2
30 cholecystitis 31.1 TP53 TLR4 EGF
31 chlamydia 31.1 TNF TLR4 IL6 IL4 CXCL8 CRP
32 ileus 31.1 TNF IL6 CRP
33 allergic hypersensitivity disease 31.1 TNF TACR1 TAC1 KNG1 IL4 IL2
34 paine syndrome 31.0 TRPV1 TACR1 TAC1 P2RX3 NGF KNG1
35 aplastic anemia 31.0 TP53 TNF IL6 IL4 IL2 CXCL8
36 chronic pyelonephritis 31.0 UMOD TLR4 CRP
37 toxic shock syndrome 31.0 TNF TLR4 IL6 IL4 IL2 CXCL8
38 cytomegalovirus infection 31.0 TNF IL6 CXCL8
39 diarrhea 31.0 TRPV1 TNF TLR4 TAC1 IL6 IL2
40 conjunctivitis 31.0 TNF IL6 IL4 IL2 CXCL8
41 exanthem 30.9 TNF IL6 IL2 CXCL8 CRP
42 endocarditis 30.9 TNF IL6 CXCL8 CRP
43 gastritis 30.9 TP53 TNF TLR4 IL6 CXCL8
44 purpura 30.9 TNF IL6 IL4 CRP
45 gastroenteritis 30.9 TNF IL6 IL4 CXCL8 CRP
46 colitis 30.9 TNF TLR4 IL6 IL4 IL2 CXCL8
47 spinal cord injury 30.9 TNF IL6 CXCL8
48 typhoid fever 30.9 TNF TLR4 IL6 CRP
49 schistosomiasis 30.9 TP53 TNF IL4 IL2
50 trichomoniasis 30.9 TNF IL6 IL2 CXCL8

Comorbidity relations with Cystitis via Phenotypic Disease Network (PDN): (show all 29)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bladder Cancer Bladder Neck Obstruction
Bronchitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hydronephrosis
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Neurogenic Bladder
Osteoporosis Paralytic Ileus
Parkinson Disease, Late-Onset Prostatic Hypertrophy
Protein-Energy Malnutrition Pyelonephritis
Radiation Cystitis Schizophreniform Disorder
Transient Cerebral Ischemia Urethral Stricture
Urethritis

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to Cystitis

Symptoms & Phenotypes for Cystitis

MGI Mouse Phenotypes related to Cystitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.28 HBEGF IL2 IL6 KNG1 NGF P2RX3
2 homeostasis/metabolism MP:0005376 10.27 CRP HBEGF IL2 IL4 IL6 KNG1
3 cardiovascular system MP:0005385 10.25 CRP HBEGF IL2 IL6 NGF P2RX3
4 immune system MP:0005387 10.13 CRP EGF IL2 IL4 IL6 P2RX3
5 integument MP:0010771 10.03 EGF HBEGF IL4 IL6 NGF P2RX3
6 renal/urinary system MP:0005367 9.76 IL4 IL6 TAC1 TLR4 TP53 TRPV1
7 respiratory system MP:0005388 9.65 HBEGF IL2 IL4 IL6 P2RX3 TACR1
8 vision/eye MP:0005391 9.28 EGF IL2 IL4 IL6 NGF TLR4

Drugs & Therapeutics for Cystitis

PubMed Health treatment related to Cystitis: 62

For many women, cystitis is a one-time unpleasant problem. In others, it may keep coming back. Antibiotics have been proven to effectively relieve acute cystitis , and they usually work quickly. There are also some home remedies that may help, like drinking plenty of fluids or applying heat. Herbal products are available too.

Drugs for Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 298)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
2
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
3
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
4
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
5
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
6
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
8
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
9
Ibuprofen Approved Phase 4 15687-27-1 3672
10
Morphine Approved, Investigational Phase 4 57-27-2 5288826
11
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Cycloserine Approved Phase 4 68-41-7 401 6234
14
Azithromycin Approved Phase 4 83905-01-5 447043 55185
15
Belladonna Approved, Experimental Phase 4
16
Methylene blue Approved, Investigational Phase 4 61-73-4
17
Ferrous fumarate Approved Phase 4 141-01-5
18
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
19
Norethindrone Approved Phase 4 68-22-4 6230
20
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
21
Polyestradiol phosphate Approved Phase 4 28014-46-2
22
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
23
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
24
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
25
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
26
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
27
Ethanol Approved Phase 4 64-17-5 702
28
Norfloxacin Approved Phase 4 70458-96-7 4539
29
Sodium citrate Approved, Investigational Phase 4 68-04-2
30
Fosfomycin Approved Phase 4 23155-02-4 446987
31
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
32
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
33
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
34
Cefoxitin Approved Phase 4 35607-66-0 441199
35
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
36
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
37
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
38
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
39 Gentamicins Phase 4
40 Solifenacin succinate Phase 4 242478-38-2
41 Ketorolac Tromethamine Phase 4
42 Analgesics, Opioid Phase 4
43 Adrenergic alpha-Agonists Phase 4
44 Parasympatholytics Phase 4
45 cefuroxime axetil Phase 4
46 cephalothin Phase 4
47 Muscarinic Antagonists Phase 4
48 Cephradine Phase 4
49 Amoxicillin-Potassium Clavulanate Combination Phase 4
50 Amdinocillin Pivoxil Phase 4

Interventional clinical trials:

(show top 50) (show all 357)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Solifenacin vs Levofloxacin vs Lornoxicam for Management of Intravesical Instillation of Bacillus Calmette-Guerin (BCG) Side Effects A Single Blinded Randomised Controlled Study Unknown status NCT03038321 Phase 4 sofenacin;Tavanic;Xefo
3 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
4 Noroxin Efficacy and Safety Trial Unknown status NCT03506256 Phase 4 Norfloxacin 400 MG
5 Randomised Clinical Trial Comparing Fosfomycin vs. Nitrofurantoin for Treatment of Uncomplicated Lower Urinary Tract Infection in Female Adults at Increased Risk of Antibiotic-resistant Bacterial Infection Unknown status NCT01966653 Phase 4 nitrofurantoin;fosfomycin
6 Randomized Placebo-Controlled Trial of Gentamicin Bladder Instillation for the Prevention of Urinary Tract Infection in Adults at High Risk for Cystitis Due to Intermittent Catheterization Unknown status NCT01884467 Phase 4 Gentamicin;Placebo
7 Botulinum A Toxin Intravesical Injections Versus Bladder Overdistension in the Treatment of Patients With Painful Bladder Syndrome: A Prospective Randomized Study Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
8 To Evaluate the Efficacy, Tolerability, and Safety of Intranasal Ketorolac Tromethamine (Sprix) as an Option for Acute (up to 5 Days) Pain Management Adult Interstitial Cystitis Patients Experiencing a Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
9 Efficacy of Combined Intravesical Therapy With Hyaluronic Acid and Chondroitin Sulphate in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract: a Multicenter, Prospective Study Completed NCT02366676 Phase 4 hyaluronic acid and chondroitin sulphate
10 A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department Completed NCT01749605 Phase 4 Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days;ciprofloxacin 250 mg BID x 3 days
11 The Impact of Injection Location on the Efficacy of Intravesicular Onabotulinumtoxin A in Interstitial Cystitis--Phase 4 Completed NCT02297100 Phase 4 Onabotulinumtoxin A
12 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
13 Efficacy of Oxybutynin in Paediatric Cystitis Completed NCT03877289 Phase 4 Oxybutynin;Antibiotics
14 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis in Adult, Non-pregnant Women Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
15 Use of Standardized Delegation Form in Diagnosing and Treating Acute Cystitis in Primary Care Facilities. Completed NCT01132131 Phase 4
16 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository: A Randomized, Double-Blind, Placebo-Controlled Trial (ROBIN Trial) Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
17 Management of Sub-Clinical Bacteriuria in Pregnancy: A Feasibility Trial Completed NCT03275623 Phase 4 Antibiotic
18 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
19 Botox (Botulinum Toxin A) as a Treatment for Interstitial Cystitis in Women: A Randomized Placebo Controlled Trial Completed NCT00194610 Phase 4 Botox
20 Brain Imaging-based Strategies for Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
21 Ciprofloxacin for Prevention of BK Infection in Renal Transplant Recipients Completed NCT01789203 Phase 4 Ciprofloxacin;placebo
22 Detection and Treatment Benefit of Microorganism (Chlamydia Trachomatis, Mycoplasma Hominis, Ureaplasma Urealyticum) in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
23 Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis Recruiting NCT03379389 Phase 4 Methenamine + Methylthioninium;Methenamine + Methylthioninium + Acriflavine + Atropa belladona;Antibiotics
24 Deciphering the Hormonal and Nociceptive Mechanisms Underlying Bladder Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
25 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
26 A Prospective Cohort Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction Active, not recruiting NCT03199534 Phase 4 Botulinum toxin A 50u;Botulinum toxin A 100u;Botulinum toxin A 150u
27 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Active, not recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
28 The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing Due to New Episodes of Urinary Tract Infections (UTI) in Elderly Women With Recurrent UTI - a Triple- Blinded, Randomized Placebo-controlled Phase IV Study Enrolling by invitation NCT04077580 Phase 4 Methenamine Hippurate 1000 MG
29 IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder Syndrome a Randomized Placebo-controlled Prospective Trial Not yet recruiting NCT04313972 Phase 4 low-dose naltrexone;Placebo oral tablet
30 Non-antimicrobial Alternative in Prophylaxis of Recurrent Urinary Tract Infections: a Prospective, Randomised-controlled, Double-blinded, Multicentre Study Not yet recruiting NCT04095572 Phase 4
31 The Effects of Sequential Mitomycin and Bacillus Calmette-Guérin Treatment Versus Bacillus Calmette-Guérin Monotherapy in Patients With High Risk Non-Muscle Invasive Bladder Cancer Not yet recruiting NCT03790384 Phase 4 Mitomycin
32 Examining the Effects of Ketamine Treatment on Synaptic Plasticity in Depression Using PET Imaging Not yet recruiting NCT04091971 Phase 4 Ketamine
33 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Evaluation of the Efficacy and Tolerability of Two Different Doses of ELMIRON for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
34 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
35 Prospective Randomised Trial Comparing Intravesical Chondroitin Sulphate 2% and DMSO in the Treatment of Painful Bladder Syndrome/ Interstitial Cystitis Terminated NCT04268810 Phase 4
36 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
37 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective, Randomised,Placebo-controlled, Double-blind Study Terminated NCT01879930 Phase 4 doxycycline;placebo
38 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
39 Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting. A Randomized, Double Blind Trial Terminated NCT01039545 Phase 4 Diclofenac;Norfloxacin
40 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
41 Nitrofurantoin Macrocrystals 3 Days Vs. 7 Days in the Treatment of Women With Uncomplicated Cystitis Withdrawn NCT00361998 Phase 4 NITROFURANTOIN MACROCRYSTALS
42 Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL) Producing and AmpC Hyperproducing Enterobacteriaceae in United Kingdom Withdrawn NCT01543347 Phase 4 Temocillin
43 The LEADERSHIP 301 Trial: A 12-Week, Randomized, Multi-Center, Double-Blind, Placebo-Controlled, 3-Arm, Parallel-Group, Phase 3 Trial to Evaluate the Efficacy and Safety of 2 Doses of AQX-1125 Targeting the Src Homology 2-containing Inositol-5'-Phosphatase 1 (SHIP1) Pathway in Subjects With Interstitial Cystitis/Bladder Pain Syndrome Followed by an Extension Period Unknown status NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
44 A Double-Blind, Randomized Study of Puncturing Versus Non-Puncturing Acupuncture for the Treatment of Interstitial Cystitis Symptoms Unknown status NCT00094874 Phase 3
45 Phase III Randomized Trial of Comparing CCRT vs. RT Alone for Cervical Cancer Patients Primarily Treated by Radiotherapy and With Clinically Defined Good-prognosis Unknown status NCT00846508 Phase 3 Cisplatin
46 Randomized Comparison of Cyclophosphamide Versus Fludarabine in Addition to Anti-thymocyte Globulin for the Conditioning Therapy in Allogeneic Hematopoietic Cell Transplantation for Adult Acquired Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
47 An Investigator Initiated, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Humira® (Adalimumab) For The Treatment of Interstitial Cystitis(IC) Completed NCT01295814 Phase 3 Adalimumab
48 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
49 Explorative Study on the Use of Omalizumab in Patients Suffering From Interstitial Cystitis/Painful Bladder Syndrome Completed NCT01294878 Phase 3 omalizumab
50 Multicentre, Prospective, Comparative, Randomized, Double-blind, Double-dummy Study to Assess the Efficacy and Safety of Cefditoren Pivoxil vs. Ciprofloxacin in Uncomplicated Acute Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carboprost
Ciprofloxacin
Mesna
Methenamine
methenamine hippurate
methenamine mandelate
METHENAMINE SULFOSALICYLATE

Cochrane evidence based reviews: cystitis

Genetic Tests for Cystitis

Anatomical Context for Cystitis

MalaCards organs/tissues related to Cystitis:

40
Prostate, Bone, Bone Marrow, Testes, Kidney, T Cells, Spinal Cord

Publications for Cystitis

Articles related to Cystitis:

(show top 50) (show all 11152)
# Title Authors PMID Year
1
Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. 61 54
19996110 2010
2
Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. 54 61
16500917 2006
3
GAP-43 immunoreactivity of subepithelial and detrusor muscle nerve fibres in patients with refractory idiopathic detrusor overactivity. 54 61
15924356 2005
4
Potential therapeutic targets for neurokinin-1 receptor antagonists. 61 54
15155133 2004
5
Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. 61 54
10702392 2000
6
Increased expression of growth-associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced cystitis. 54 61
10536274 1999
7
[Evaluation of N-acetyl-beta glucosaminidase in upper and lower urinary tract infections in childhood. Clinical study of 168 children]. 61 54
9064498 1996
8
Tamm-Horsfall protein in bladder tissue. Morphologic spectrum and clinical significance. 54 61
8179076 1994
9
Urinary N-acetyl-beta-glucosaminidase and the selection of children for radiologic evaluation after urinary tract infection. 61 54
2371096 1990
10
Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients. 61
32153257 2020
11
Data highlighting phenotypic diversity of urine-associated Escherichia coli isolates. 61
32566710 2020
12
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis. 61
32220624 2020
13
[Preoperative intensity-modulated radiotherapy of rectal cancers: Relevance and modalities]. 61
32360094 2020
14
Incidental discovery of an interstitial emphysematous cystitis with liver abscess: A report of hematogenous spread of infection. 61
32195123 2020
15
The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS? 61
32358624 2020
16
Botulinum toxin in low urinary tract disorders - over 30 years of practice (Review). 61
32509003 2020
17
Successful Treatment of Urinary Bladder Hemangiosarcoma by Partial Cystectomy in a Dog. 61
32412336 2020
18
Radiation of the urinary bladder attenuates the development of lipopolysaccharide-induced cystitis. 61
32179244 2020
19
Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer. 61
32534450 2020
20
Urease-Powered Polydopamine Nanomotors for Intravesical Therapy of Bladder Diseases. 61
32491832 2020
21
Cidofovir intravesical, use in BK poliomavirus associated haemorrhagic cystitis after a transplantation of hematopoyetic progenitors: Off-label. 61
32513510 2020
22
Evaluation of the trends and appropriateness of fluoroquinolone use in the outpatient treatment of acute uncomplicated cystitis at five family practice clinics. 61
31821580 2020
23
Costing Urologic Complications Following Pelvic Radiation Therapy. 61
32194089 2020
24
Decreased Outpatient Fluoroquinolone Prescribing Using a Multimodal Antimicrobial Stewardship Initiative. 61
32548204 2020
25
[Urolithiasis in a pet rat (Rattus norvegicus)]. 61
32557497 2020
26
Urolithiasis and cystitis associated with Staphylococcus delphini group A and mortality in post-weaning mink kits (Neovison vison). 61
32456816 2020
27
Recurrence rate and long-term course of cats with feline lower urinary tract disease. 61
31322040 2020
28
Relationship between low serum vitamin D status and urinary tract infection in children: a case-control study. 61
32490740 2020
29
Vaccination of koalas during antibiotic treatment for Chlamydia-induced cystitis induces an improved antibody response to Chlamydia pecorum. 61
32576914 2020
30
Pentosan polysulfate sodium-induced pigmentary maculopathy with non-leaking cystoid macular edema successfully treated with anti-VEGF therapy. 61
32541441 2020
31
Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study. 61
32578247 2020
32
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis). 61
32284384 2020
33
Infections after Allogenic Transplant with Post-Transplant Cyclophosphamide: Impact of Donor HLA Matching. 61
32004700 2020
34
A case series of post-transplant cyclophosphamide in unrelated donor hematopoietic transplantation for aplastic anemia. 61
32504863 2020
35
[Clinical Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Treatment of 12 Patients with Acute Leukemia in Tropical Area]. 61
32552930 2020
36
Intravesicular Cidofovir in the Treatment of BK Virus-Associated Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation. 61
31876431 2020
37
BK virus infection in allogeneic hematopoietic cell transplantation: An update on pathogenesis, immune responses, diagnosis and treatments. 61
32526327 2020
38
Outcome of pulse oral cyclophosphamide therapy in scleroderma interstitial lung disease. 61
32519048 2020
39
Opioid prescription use in patients with interstitial cystitis. 61
31980841 2020
40
Commentary on "Opioid prescription use in patients with interstitial cystitis". 61
32333063 2020
41
Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis. 61
32544050 2020
42
Re: Update on the Pathophysiology of Interstitial Cystitis/Bladder Pain Syndrome. 61
32567966 2020
43
Editorial Comment to Clinical guidelines for interstitial cystitis/bladder pain syndrome. 61
32542820 2020
44
Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives. 61
32246572 2020
45
Urine cytokines as biomarkers for diagnosing interstitial cystitis/bladder pain syndrome and mapping its clinical characteristics. 61
32281420 2020
46
Hunner Lesion Interstitial Cystitis: The Bad, The Good, and The Unknown. 61
32507337 2020
47
Platelet-Rich Plasma Ameliorates Cyclophosphamide-Induced Acute Interstitial Cystitis/Painful Bladder Syndrome in a Rat Model. 61
32521683 2020
48
Isolation of thymidine-dependent and extended-spectrum-β-lactamase-producing Escherichia coli small-colony variant from urine of a septuagenarian female patient with recurrent cystitis: A case report with genetic investigation. 61
32571646 2020
49
Dosimetric predictors of genitourinary toxicity from a phase I trial of prostate bed stereotactic body radiation therapy. 61
32562789 2020
50
Translational Aspects of Nuclear Factor-Kappa B and Its Modulation by Thalidomide on Early and Late Radiation Sequelae in Urinary Bladder Dysfunction. 61
32035188 2020

Variations for Cystitis

Expression for Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for Cystitis

Pathways related to Cystitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 VIM TP53 TNF NGF IL6 IL4
2
Show member pathways
13.57 TP53 TNF NGF IL6 IL4 IL2
3
Show member pathways
13.44 TP53 TNF TLR4 NGF IL6 IL4
4
Show member pathways
13.39 VIM TP53 TNF IL6 IL4 IL2
5
Show member pathways
13.35 TRPV1 P2RX3 NGF IL6 IL2 HBEGF
6
Show member pathways
13.32 TNF NGF IL6 IL4 IL2 HBEGF
7
Show member pathways
13.23 TP53 TNF TLR4 IL4 IL2 HBEGF
8
Show member pathways
13.09 TP53 NGF IL6 IL2 HBEGF EGF
9
Show member pathways
13.06 NGF IL6 IL4 IL2 HBEGF EGF
10
Show member pathways
13.05 TP53 TNF TLR4 KNG1 IL6 IL2
11
Show member pathways
12.97 TP53 TNF TLR4 NGF IL6 IL4
12
Show member pathways
12.88 VIM TNF IL6 IL4 IL2 CXCL8
13 12.86 TP53 KNG1 IL6 IL4 IL2 EGF
14
Show member pathways
12.83 VIM TP53 TNF TLR4 IL6 IL2
15
Show member pathways
12.74 TNF TLR4 NGF IL6 IL2 EGF
16
Show member pathways
12.62 TNF TLR4 IL6 IL4 IL2
17
Show member pathways
12.58 VIM TNF TLR4 IL6 IL4 IL2
18 12.42 TP53 TNF TLR4 CXCL8
19 12.36 TP53 TNF IL6 IL2
20
Show member pathways
12.36 TNF IL6 IL4 CXCL8
21
Show member pathways
12.36 TP53 TNF TLR4 IL6 CXCL8
22
Show member pathways
12.35 TNF IL6 IL2 CXCL8
23
Show member pathways
12.33 TP53 IL6 HBEGF EGF
24
Show member pathways
12.33 TP53 TNF IL6 IL4 IL2 CRP
25 12.32 TNF TLR4 IL6 CXCL8
26 12.32 TP53 TNF TLR4 HBEGF
27 12.28 TNF TLR4 IL6 CXCL8
28
Show member pathways
12.28 TNF TLR4 IL6 CXCL8
29 12.25 TNF TLR4 IL6 CXCL8
30 12.23 TP53 TNF TLR4 IL6 EGF
31
Show member pathways
12.22 TNF TLR4 IL6 IL4 CXCL8
32 12.09 TNF TACR1 TAC1 NGF IL6 CXCL8
33 12.03 TNF IL6 IL4 IL2
34 12.02 TNF TLR4 IL6 IL2 CXCL8
35
Show member pathways
11.98 TNF TLR4 IL6 IL2
36 11.96 TNF TLR4 IL6 CXCL8
37 11.92 TNF TLR4 IL6 CXCL8
38 11.81 TNF IL4 IL2
39 11.81 TNF TLR4 IL6 CXCL8
40
Show member pathways
11.81 TNF IL4 IL2 CXCL8
41 11.8 VIM NGF EGF
42 11.79 TP53 IL6 IL4 IL2 CXCL8
43 11.77 TNF IL6 IL2
44
Show member pathways
11.77 TP53 TNF NGF IL6 IL4 IL2
45
Show member pathways
11.72 TNF IL6 IL2 CXCL8
46 11.7 IL6 HBEGF CXCL8
47 11.69 UPK3A TP53 HBEGF EGF CXCL8
48 11.69 VIM TP53 TNF IL6 IL4 CXCL8
49 11.66 TNF TLR4 IL6 CXCL8
50 11.58 TNF TLR4 IL6 CXCL8

GO Terms for Cystitis

Cellular components related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 VIM UPK3A UPK1A UMOD TRPV1 TNF
2 cell GO:0005623 9.8 TRPV1 TACR1 TAC1 P2RX3 KNG1 IL6
3 extracellular region GO:0005576 9.73 UMOD TNF TAC1 NGF KNG1 IL6
4 extracellular space GO:0005615 9.4 UMOD TNF TAC1 NGF KNG1 IL6
5 apical plasma membrane urothelial plaque GO:0120001 9.16 UPK3A UPK1A

Biological processes related to Cystitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.03 UMOD TP53 NGF IL6 CXCL8
2 immune response GO:0006955 10 TNF TLR4 IL6 IL4 IL2 CXCL8
3 positive regulation of apoptotic process GO:0043065 9.91 TRPV1 TP53 TNF NGF KNG1 IL6
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 TP53 IL6 HBEGF EGF
5 positive regulation of T cell proliferation GO:0042102 9.79 IL6 IL4 IL2
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 TNF IL6 HBEGF
7 positive regulation of interleukin-6 production GO:0032755 9.77 TNF TLR4 IL6
8 cellular response to lipopolysaccharide GO:0071222 9.77 VIM TNF TLR4 IL6 CXCL8
9 positive regulation of interferon-gamma production GO:0032729 9.75 TNF TLR4 IL2
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 TRPV1 TNF TLR4
11 positive regulation of B cell proliferation GO:0030890 9.72 TLR4 IL4 IL2
12 positive regulation of cytosolic calcium ion concentration GO:0007204 9.72 TRPV1 TACR1 TAC1 KNG1 IL2
13 microglial cell activation GO:0001774 9.71 TRPV1 TNF IL4
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IL6 IL4 IL2
15 cytokine-mediated signaling pathway GO:0019221 9.7 VIM TP53 TNF IL6 IL4 IL2
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.67 TNF TLR4 IL6
17 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.65 TP53 IL6
18 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.65 TP53 TNF
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IL4 IL2
20 response to pain GO:0048265 9.65 TRPV1 TACR1 TAC1
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 TLR4 IL4
22 response to salt stress GO:0009651 9.64 TP53 TNF
23 negative regulation of T-helper 17 cell differentiation GO:2000320 9.63 IL4 IL2
24 positive regulation of chemokine production GO:0032722 9.63 TNF TLR4 IL6
25 positive regulation of lymphocyte proliferation GO:0050671 9.62 TLR4 TAC1
26 tachykinin receptor signaling pathway GO:0007217 9.62 TACR1 TAC1
27 positive regulation of gene expression GO:0010628 9.61 VIM TP53 TNF TLR4 NGF IL6
28 positive regulation of mononuclear cell migration GO:0071677 9.59 TNF IL4
29 urinary bladder smooth muscle contraction GO:0014832 9.58 TRPV1 P2RX3
30 detection of abiotic stimulus GO:0009582 9.56 TACR1 TAC1
31 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
32 inflammatory response GO:0006954 9.28 TRPV1 TNF TLR4 TACR1 TAC1 KNG1

Molecular functions related to Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IL4 IL2 CXCL8
2 growth factor activity GO:0008083 9.1 NGF IL6 IL4 IL2 HBEGF EGF

Sources