MCID: CYS003
MIFTS: 36

Cystitis Cystica

Categories: Nephrological diseases

Aliases & Classifications for Cystitis Cystica

MalaCards integrated aliases for Cystitis Cystica:

Name: Cystitis Cystica 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:7138
ICD9CM 35 595.81
NCIt 50 C96230
SNOMED-CT 68 13285005
UMLS 72 C0152262

Summaries for Cystitis Cystica

Disease Ontology : 12 A cysititis that is characterized by hyperplasia of bladder submucosa and cyst formation caused by chronic irritation of the bladder.

MalaCards based summary : Cystitis Cystica is related to glandular cystitis and appendix adenocarcinoma. An important gene associated with Cystitis Cystica is HYAL1 (Hyaluronidase 1), and among its related pathways/superpathways are Pathways in cancer and Cytoskeletal Signaling. Affiliated tissues include kidney, prostate and colon, and related phenotypes are cellular and digestive/alimentary

Wikipedia : 75 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Cystitis Cystica

Diseases related to Cystitis Cystica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 glandular cystitis 31.7 KRT7 KRT20 CDX2
2 appendix adenocarcinoma 30.9 KRT7 KRT20 CDX2
3 mucinous adenocarcinoma 30.9 KRT7 KRT20 CDX2
4 chronic cystitis 30.9 KRT7 KRT20 CDX2
5 bladder adenocarcinoma 30.5 KRT7 KRT20 CTNNB1 CDX2
6 urethral syndrome 11.5
7 cystitis 11.0
8 ovary neuroendocrine neoplasm 10.8 KRT7 CDX2
9 mucinous adenofibroma 10.7 KRT7 CDX2
10 cystic basal cell carcinoma 10.7 KRT7 KRT20
11 vaginal tubulovillous adenoma 10.7 KRT20 CDX2
12 vaginal adenoma 10.7 KRT20 CDX2
13 malignant syringoma 10.7 KRT7 KRT20
14 vaginal benign neoplasm 10.7 KRT20 CDX2
15 transverse colon cancer 10.7 KRT7 KRT20
16 prostate transitional cell carcinoma 10.7 KLK3 CTNNB1
17 krukenberg carcinoma 10.7 KRT7 KRT20
18 eyelid carcinoma 10.7 KRT7 KRT20
19 papillary transitional carcinoma 10.7 KRT7 KRT20
20 bartholin's duct cyst 10.7 GATA3 AR
21 small cell carcinoma of the bladder 10.6 KRT7 KRT20
22 cribriform carcinoma 10.6 KRT7 GATA3
23 bladder carcinoma in situ 10.6 UPK2 KRT7
24 linitis plastica 10.6 KRT7 KRT20
25 duodenum adenocarcinoma 10.6 KRT7 CDX2
26 benign breast adenomyoepithelioma 10.6 KRT7 KRT5
27 balloon cell malignant melanoma 10.6 KRT7 KRT5
28 oncocytic breast carcinoma 10.6 KRT7 AR
29 papillary craniopharyngioma 10.6 KRT7 CTNNB1
30 intratubular embryonal carcinoma 10.6 KRT7 KRT20
31 adenoid squamous cell carcinoma 10.6 KRT7 KRT20
32 malignant spiradenoma 10.6 KRT7 KRT5
33 benign mesothelioma 10.6 KRT7 KRT5
34 gastric signet ring cell adenocarcinoma 10.6 UPK2 GATA3 CDX2
35 goblet cell carcinoid 10.6 KRT20 CTNNB1
36 middle ear adenoma 10.6 KRT7 KRT5
37 sensory organ benign neoplasm 10.6 KRT7 KRT5
38 bile duct adenoma 10.6 KRT7 KRT20
39 atrophy of prostate 10.6 SLC2A1 KLK3
40 large cell acanthoma 10.6 KRT7 KRT5
41 renal pelvis adenocarcinoma 10.6 SLC2A1 KRT7
42 apocrine sweat gland neoplasm 10.5 KRT7 KRT5
43 appendix disease 10.5 KRT7 KRT20 CDX2
44 thymus adenocarcinoma 10.5 KRT7 KRT20 CDX2
45 ovarian mucinous adenocarcinoma 10.5 KRT7 KRT20 CDX2
46 vulval paget's disease 10.5 KRT7 KRT20
47 jejunal adenocarcinoma 10.5 KRT7 KRT20 CDX2
48 vulva adenocarcinoma 10.5 KRT7 KRT20 CDX2
49 nephrogenic adenoma 10.5 KRT7 KLK3
50 signet ring cell adenocarcinoma 10.5 KRT7 KRT20 CDX2

Comorbidity relations with Cystitis Cystica via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Cancer
Bladder Neck Obstruction Hydronephrosis
Prostate Cancer Prostatic Hypertrophy
Urethral Stricture

Graphical network of the top 20 diseases related to Cystitis Cystica:



Diseases related to Cystitis Cystica

Symptoms & Phenotypes for Cystitis Cystica

MGI Mouse Phenotypes related to Cystitis Cystica:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 AR CDX2 CTNNB1 FSCN1 GATA3 KRT7
2 digestive/alimentary MP:0005381 9.86 AR CDX2 CTNNB1 GATA3 KRT5 MUC5AC
3 embryo MP:0005380 9.76 AR CDX2 CTNNB1 FSCN1 GATA3 MCL1
4 immune system MP:0005387 9.65 AR CDH17 CTNNB1 FSCN1 GATA3 HYAL1
5 reproductive system MP:0005389 9.23 AR CDX2 CTNNB1 GATA3 MCL1 SPAM1

Drugs & Therapeutics for Cystitis Cystica

Search Clinical Trials , NIH Clinical Center for Cystitis Cystica

Genetic Tests for Cystitis Cystica

Anatomical Context for Cystitis Cystica

MalaCards organs/tissues related to Cystitis Cystica:

41
Kidney, Prostate, Colon, Testes, Cervix, Spinal Cord

Publications for Cystitis Cystica

Articles related to Cystitis Cystica:

(show top 50) (show all 155)
# Title Authors PMID Year
1
Is trigonitis a neglected, imprecise, misunderstood, or forgotten diagnosis? 38
30989795 2019
2
Mimickers of urothelial neoplasia. 38
30380401 2019
3
Cystitis Cystica on Routine Cystoscopy at Time of Total Laparoscopic Hysterectomy. 38
30735732 2019
4
Diagnostic Value of Glucose Transporter 1 (GLUT-1) Expression in Nested Variant of Urothelial Carcinoma. 38
30035295 2019
5
Cystitis cystica and glandularis producing large bladder masses in a 16-year-old boy. 38
29552345 2018
6
Cystitis Cystica Glandularis: Radiological Imitator of Urothelial Carcinoma. 38
29421770 2018
7
Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway. 38
29162939 2017
8
Correlation of Bladder Histopathologic Changes Due to Double-J Stenting to the Period of Stenting: A Preliminary Study. 38
28467731 2017
9
Cystitis glandularis: Management and challenges in a renal transplant recipient. 38
28717279 2017
10
Cystitis Cystica as a Large Solitary Bladder Cyst. 38
28466074 2017
11
Prolapsing cystitis cystica causing bladder outlet obstruction: An unusual complication. 38
27843222 2016
12
Differential diagnosis of bladder versus colorectal adenocarcinoma: keratin 7 and GATA3 positivity in nuclear ß-catenin-negative glandular tumours defines adenocarcinoma of the bladder. 38
26463756 2016
13
Carcinoma of the Uterine Cervix Involving the Genitourinary Tract: A Potential Diagnostic Dilemma. 38
26426382 2016
14
Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation. 38
27006847 2016
15
Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging. 38
26048699 2015
16
[Ferdinand Albert Wilhelm von Brunn (1849-1895): Rostock's contribution to urology at the end of the 19th century]. 38
25875930 2015
17
Distinguishing nested variants of urothelial carcinoma from benign mimickers by TERT promoter mutation. 38
25118812 2015
18
Extensive xanthogranulomatous cystitis mimicking bladder cancer. 38
25371622 2014
19
Ultrasound distinction between simple recurrent urinary tract infections and a specific bladder wall inflammatory entity called cystitis cystica. 38
24851610 2014
20
Long-term incidence of febrile UTI after DxHA treatment of VUR. 38
23810062 2014
21
Positive feedback loop for cystitis cystica: the effect of recurrent urinary tract infection on the number of bladder wall mucosa nodules. 38
24696993 2013
22
Ultrasound bladder wall thickness measurement in diagnosis of recurrent urinary tract infections and cystitis cystica in prepubertal girls. 38
23725853 2013
23
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients. 38
22520573 2013
24
Metaplastic conditions of the bladder. 38
24127673 2013
25
[Primary large cell neuroendocrine carcinoma of the urinary bladder]. 38
23641713 2013
26
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. 38
23451748 2013
27
Microcystic variant of urothelial carcinoma. 38
24363668 2013
28
Urinary bladder sinuses: a novel morphologic lesion with clinical and pathologic significance. 38
22495363 2012
29
Nonneoplastic lesions of the prostate and bladder. 38
22742546 2012
30
Genitourinary schistosomiasis: life cycle and radiologic-pathologic findings. 38
22786992 2012
31
Recurrent transitional cell carcinoma of the bladder: A mixed nested variant case report and literature review. 38
22511434 2012
32
A rare case of recurrent urinary obstruction and acute renal failure from cystitis cystica et glandularis. 38
22511438 2012
33
Cystitis cystica and cystitis glandularis causing ureteral obstruction. 38
22266000 2012
34
Malignant glandular lesions and glandular differentiation in invasive/noninvasive urothelial carcinoma of the urinary bladder. 38
21855380 2011
35
Polyps and masses of the pediatric urinary bladder: a 21-year pathology review. 38
21793666 2011
36
Glandular lesions of the urinary bladder:clinical significance and differential diagnosis. 38
20854477 2011
37
Primary carcinoid tumors of the urinary bladder and prostatic urethra: a clinicopathologic study of 6 cases. 38
21317716 2011
38
Cystitis cystica and recurrent urinary tract infections in children. 38
20977079 2010
39
Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases. 38
19800100 2010
40
Rare etiology of obstructive uropathy: pelvic lipomatosis. 38
20215833 2010
41
Urothelial carcinoma with villoglandular differentiation: a study of 14 cases. 38
19593329 2009
42
Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. 38
19252435 2009
43
Morphological evaluation of cystitis glandularis. 38
19332913 2009
44
Cystitis glandularis forming a tumorous lesion in the urinary bladder: A rare appearance of disease. 38
19468518 2008
45
Multicystic urothelial carcinoma of the bladder with gland-like lumina and with signet-ring cells. A case report. 38
18768087 2008
46
Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma. 38
18455631 2008
47
Schistosoma haematobium (Egyptian strain): rate of development and effect of praziquantel treatment. 38
18564739 2008
48
Etiological study on cystitis glandularis caused by bacterial infection. 38
18231741 2007
49
Nested variant of urothelial carcinoma. 38
17979494 2007
50
Detection of residual tumor cells in bladder biopsy specimens: pitfalls in the interpretation of cytokeratin stains. 38
17325480 2007

Variations for Cystitis Cystica

Expression for Cystitis Cystica

Search GEO for disease gene expression data for Cystitis Cystica.

Pathways for Cystitis Cystica

GO Terms for Cystitis Cystica

Cellular components related to Cystitis Cystica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.28 UPK2 SLC2A1 MUC5AC KRT7 KRT5 KLK3
2 cell projection membrane GO:0031253 8.96 FSCN1 CTNNB1

Biological processes related to Cystitis Cystica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.61 KRT7 KRT5 KRT20
2 positive regulation of cell differentiation GO:0045597 9.5 GATA3 CDX2 AR
3 regulation of systemic arterial blood pressure GO:0003073 9.4 KLK3 AR
4 cellular process GO:0009987 9.37 CTNNB1 AR
5 epithelial cell differentiation involved in prostate gland development GO:0060742 9.26 CTNNB1 AR
6 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 9.16 CTNNB1 AR
7 regulation of nephron tubule epithelial cell differentiation GO:0072182 8.96 GATA3 CTNNB1
8 cell fate determination GO:0001709 8.8 MCL1 GATA3 CTNNB1

Molecular functions related to Cystitis Cystica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.26 HYAL1 GATA3 CTNNB1 AR
2 hyalurononglucosaminidase activity GO:0004415 8.62 SPAM1 HYAL1

Sources for Cystitis Cystica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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