MCID: CYT019
MIFTS: 33

Cytogenetically Normal Acute Myeloid Leukemia

Categories: Cancer diseases

Aliases & Classifications for Cytogenetically Normal Acute Myeloid Leukemia

MalaCards integrated aliases for Cytogenetically Normal Acute Myeloid Leukemia:

Name: Cytogenetically Normal Acute Myeloid Leukemia 25 73
Acute Myelogenous Leukemia with Normal Karyotype 25
Normal Karyotype Acute Myeloid Leukemia 25
Cn-Aml 25
Nk-Aml 25

Classifications:



External Ids:

UMLS 73 C3839868

Summaries for Cytogenetically Normal Acute Myeloid Leukemia

Genetics Home Reference : 25 Cytogenetically normal acute myeloid leukemia (CN-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and cell fragments called platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.

MalaCards based summary : Cytogenetically Normal Acute Myeloid Leukemia, also known as acute myelogenous leukemia with normal karyotype, is related to mn1 and leukemia. An important gene associated with Cytogenetically Normal Acute Myeloid Leukemia is FLT3 (Fms Related Tyrosine Kinase 3), and among its related pathways/superpathways are Glucose / Energy Metabolism and Peroxisome. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Cytogenetically Normal Acute Myeloid Leukemia

Diseases related to Cytogenetically Normal Acute Myeloid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 mn1 30.7 FLT3 KMT2A
2 leukemia 30.1 CEBPA FLT3 NPM1 WT1
3 wilms tumor 1 29.3 CEBPA FLT3 NPM1 WT1
4 myeloid leukemia 28.7 CEBPA FLT3 IDH1 NPM1 WT1
5 acute promyelocytic leukemia 28.7 CEBPA FLT3 NPM1 WT1
6 acute leukemia 28.5 CEBPA FLT3 KMT2A WT1
7 leukemia, acute myeloid 26.9 CEBPA FLT3 IDH1 IDH2 KMT2A NPM1
8 myelodysplastic syndrome 25.4 CEBPA FLT3 IDH1 IDH2 KMT2A NPM1
9 acute myeloblastic leukemia without maturation 10.5 FLT3 NPM1
10 acute myeloblastic leukemia with maturation 10.5 FLT3 NPM1
11 aleukemic leukemia cutis 10.4 FLT3 NPM1
12 chronic eosinophilic leukemia 10.3 FLT3 WT1
13 lymphoid leukemia 10.3 FLT3 KMT2A
14 wilms tumor 5 10.3
15 wilms tumor 6 10.3
16 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.3 FLT3 KMT2A
17 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.3 CEBPA FLT3
18 aging 10.1
19 leukemia, acute lymphoblastic 3 10.0 FLT3 KMT2A
20 myeloid sarcoma 9.9 FLT3 KMT2A NPM1
21 hematopoietic stem cell transplantation 9.9
22 leukemia, acute lymphoblastic 9.9 FLT3 KMT2A
23 interval angle-closure glaucoma 9.8 IDH1 IDH2
24 adult oligodendroglioma 9.8 IDH1 IDH2
25 enchondroma 9.8 IDH1 IDH2
26 intracranial chondrosarcoma 9.8 IDH1 IDH2
27 chondroblastic osteosarcoma 9.8 IDH1 IDH2
28 intraductal papilloma 9.8 IDH1 IDH2
29 multiple enchondromatosis, maffucci type 9.8 IDH1 IDH2
30 pilocytic astrocytoma of cerebellum 9.8 IDH1 IDH2
31 spindle cell hemangioma 9.8 IDH1 IDH2
32 glioma susceptibility 1 9.8 IDH1 IDH2
33 precursor t-cell acute lymphoblastic leukemia 9.8 FLT3 KMT2A
34 periosteal chondrosarcoma 9.8 IDH1 IDH2
35 leukemia, chronic myeloid 9.7 FLT3 KMT2A WT1
36 adult astrocytic tumour 9.7 IDH1 IDH2
37 core binding factor acute myeloid leukemia 9.7 CEBPA FLT3 WT1
38 fibrillary astrocytoma 9.7 IDH1 IDH2
39 undifferentiated pleomorphic sarcoma 9.7 IDH1 IDH2
40 drug-induced mental disorder 9.7 IDH1 IDH2
41 drug psychosis 9.7 IDH1 IDH2
42 diffuse infiltrative lymphocytosis syndrome 9.7 IDH1 IDH2
43 2-hydroxyglutaric aciduria 9.6 IDH1 IDH2
44 brain stem glioma 9.6 IDH1 IDH2
45 breast papillary carcinoma 9.6 IDH1 IDH2
46 d-2-hydroxyglutaric aciduria 1 9.6 IDH1 IDH2
47 enchondromatosis, multiple, ollier type 9.6 IDH1 IDH2
48 bile duct adenocarcinoma 9.5 IDH1 IDH2
49 intrahepatic cholangiocarcinoma 9.4 IDH1 IDH2
50 myelofibrosis 9.4 FLT3 IDH1 IDH2

Graphical network of the top 20 diseases related to Cytogenetically Normal Acute Myeloid Leukemia:



Diseases related to Cytogenetically Normal Acute Myeloid Leukemia

Symptoms & Phenotypes for Cytogenetically Normal Acute Myeloid Leukemia

GenomeRNAi Phenotypes related to Cytogenetically Normal Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 WT1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.7 FLT3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.7 FLT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.7 FLT3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.7 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.7 CEBPA FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.7 WT1 CEBPA FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.7 FLT3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.7 WT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.7 FLT3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 WT1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.7 WT1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 FLT3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.7 WT1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.7 WT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 CEBPA WT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.7 WT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.7 FLT3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.7 CEBPA WT1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.65 CEBPA FLT3 WT1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.65 CEBPA
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.65 FLT3
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.65 FLT3
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.65 FLT3
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.65 CEBPA
26 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.65 CEBPA
27 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.65 CEBPA

MGI Mouse Phenotypes related to Cytogenetically Normal Acute Myeloid Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 FLT3 IDH1 KMT2A NPM1 WT1 CEBPA
2 cardiovascular system MP:0005385 9.8 CEBPA IDH2 KMT2A NPM1 WT1
3 hematopoietic system MP:0005397 9.8 CEBPA FLT3 IDH1 KMT2A NPM1 WT1
4 immune system MP:0005387 9.73 CEBPA FLT3 IDH1 KMT2A NPM1 WT1
5 liver/biliary system MP:0005370 9.46 CEBPA KMT2A NPM1 WT1
6 neoplasm MP:0002006 9.43 CEBPA FLT3 IDH2 KMT2A NPM1 WT1
7 no phenotypic analysis MP:0003012 8.92 CEBPA FLT3 KMT2A WT1

Drugs & Therapeutics for Cytogenetically Normal Acute Myeloid Leukemia

Search Clinical Trials , NIH Clinical Center for Cytogenetically Normal Acute Myeloid Leukemia

Genetic Tests for Cytogenetically Normal Acute Myeloid Leukemia

Anatomical Context for Cytogenetically Normal Acute Myeloid Leukemia

MalaCards organs/tissues related to Cytogenetically Normal Acute Myeloid Leukemia:

41
Myeloid, Bone, Bone Marrow, T Cells

Publications for Cytogenetically Normal Acute Myeloid Leukemia

Articles related to Cytogenetically Normal Acute Myeloid Leukemia:

(show top 50) (show all 102)
# Title Authors Year
1
High Expression of TET1 Predicts Poor Survival in Cytogenetically Normal Acute Myeloid Leukemia From Two Cohorts. ( 29402726 )
2018
2
Mutation profile and associated clinical features in Chinese patients with cytogenetically normal acute myeloid leukemia. ( 29573577 )
2018
3
Up-regulation of regulatory T cells, CD200 and TIM3 expression in cytogenetically normal acute myeloid leukemia. ( 29843224 )
2018
4
Successful Treatment of Cytogenetically Normal Acute Myeloid Leukemia With Ten-Eleven Translocation 2-Isocitrate Dehydrogenase 2 and Additional Sex Comb-like 1-Nucleophosmin Co-mutations by HLA Haploidentical Stem Cell Transplantation: A Case Report and Literature Review. ( 29661468 )
2018
5
Lower expression of bone marrow miR-122 is an independent risk factor for overall survival in cytogenetically normal acute myeloid leukemia. ( 29627222 )
2018
6
Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia. ( 28960408 )
2018
7
Evolution of cytogenetically normal acute myeloid leukemia during therapy and relapse: An exome sequencing study of 50 patients. ( 29330206 )
2018
8
MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia. ( 29540187 )
2018
9
A novel type of NPM1 mutation characterized by multiple internal tandem repeats in a case of cytogenetically normal acute myeloid leukemia. ( 29903763 )
2018
10
Low NKD1 expression predicts adverse prognosis in cytogenetically normal acute myeloid leukemia. ( 28443469 )
2017
11
<i>KRAS</i> overexpression independent of<i>RAS</i>mutations confers an adverse prognosis in cytogenetically normal acute myeloid leukemia. ( 29029494 )
2017
12
Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients. ( 28679652 )
2017
13
Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia. ( 28473620 )
2017
14
High CD200 expression is associated with poor prognosis in cytogenetically normal acute myeloid leukemia, even in FlT3-ITD-/NPM1+ patients. ( 28407515 )
2017
15
A 3-miRNA signature predicts prognosis of pediatric and adolescent cytogenetically normal acute myeloid leukemia. ( 28473658 )
2017
16
E-26 Transformation-specific Related Gene Expression and Outcomes in Cytogenetically Normal Acute Myeloid Leukemia: A Meta-analysis. ( 28584213 )
2017
17
TET2 expression is a potential prognostic and predictive biomarker in cytogenetically normal acute myeloid leukemia. ( 29219176 )
2017
18
Impact of fludarabine-based induction therapy on outcome of FLT3-/NPM1+ cytogenetically normal acute myeloid leukemia. ( 28076884 )
2017
19
Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia. ( 28340577 )
2017
20
Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia. ( 28197208 )
2017
21
Phe354Leu Polymorphism of LKB1 Is a Potential Prognostic Factor for Cytogenetically Normal Acute Myeloid Leukemia. ( 28882949 )
2017
22
Association of a cytarabine chemosensitivity related gene expression signature with survival in cytogenetically normal acute myeloid leukemia. ( 27903973 )
2016
23
TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia. ( 27884166 )
2016
24
Persistent DNMT3A mutation burden in DNMT3A mutated adult cytogenetically normal acute myeloid leukemia patients in long-term remission. ( 27626217 )
2016
25
The effect of FLT3-ITD and NPM1 mutation on survival in intensively treated elderly patients with cytogenetically normal acute myeloid leukemia - Response to Rashidi etA al. ( 27090743 )
2016
26
The effect of FLT3-ITD and NPM1 mutation on survival in intensively treated elderly patients with cytogenetically normal acute myeloid leukemia. ( 27003236 )
2016
27
High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia. ( 26910834 )
2016
28
High expression of MAP7 predicts adverse prognosis in young patients with cytogenetically normal acute myeloid leukemia. ( 27686215 )
2016
29
Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia. ( 25924238 )
2015
30
Deregulation of miR-1, miR486, and let-7a in cytogenetically normal acute myeloid leukemia: association with NPM1 and FLT3 mutation and clinical characteristics. ( 26526573 )
2015
31
Immunological markers for prognostication in cytogenetically normal acute myeloid leukemia. ( 26317398 )
2015
32
Identification of the NUP98-PHF23 fusion gene in pediatric cytogenetically normal acute myeloid leukemia by whole-transcriptome sequencing. ( 26066811 )
2015
33
Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia. ( 26506237 )
2015
34
Impact of genomics in the clinical management of patients with cytogenetically normal acute myeloid leukemia. ( 26590764 )
2015
35
Prevalence and Clinical Effect of IDH1 and IDH2 Mutations Among Cytogenetically Normal Acute Myeloid Leukemia Patients. ( 26189213 )
2015
36
Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia. ( 26177509 )
2015
37
Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia. ( 25646775 )
2015
38
High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia. ( 25779662 )
2015
39
TET2 gene mutation is unfavorable prognostic factor in cytogenetically normal acute myeloid leukemia patients with NPM1+ and FLT3-ITD - mutations. ( 24859829 )
2014
40
Impact of additional genetic alterations on the outcome of patients with NPM1-mutated cytogenetically normal acute myeloid leukemia. ( 25552703 )
2014
41
DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome. ( 24512939 )
2014
42
Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia. ( 24711548 )
2014
43
NPM1 gene mutation in Egyptian patients with cytogenetically normal acute myeloid leukemia. ( 25648021 )
2014
44
BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia. ( 24413067 )
2014
45
Cytogenetically Normal Acute Myeloid Leukemia with a Novel KIT Mutation in Exon 11 G565V Developing a Sole Trisomy 13 at Relapse: A Clinical Dilemma. ( 24968822 )
2014
46
Wilms tumor 1 gene mutations in patients with cytogenetically normal acute myeloid leukemia. ( 25035671 )
2014
47
Prognostic relevance of Wilms tumor 1 (WT1) gene Exon 7 mutations in-patient with cytogenetically normal acute myeloid leukemia. ( 25435718 )
2014
48
TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implications and evolutionary patterns. ( 24898826 )
2014
49
Prognostic implications of NPM1 mutations and FLT3 internal tandem duplications in Egyptian patients with cytogenetically normal acute myeloid leukemia. ( 23540998 )
2014
50
A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes. ( 25030037 )
2014

Variations for Cytogenetically Normal Acute Myeloid Leukemia

Expression for Cytogenetically Normal Acute Myeloid Leukemia

Search GEO for disease gene expression data for Cytogenetically Normal Acute Myeloid Leukemia.

Pathways for Cytogenetically Normal Acute Myeloid Leukemia

Pathways related to Cytogenetically Normal Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 CEBPA IDH1 IDH2
2 11.24 IDH1 IDH2
3 11.19 CEBPA FLT3 KMT2A WT1
4 11.07 FLT3 IDH1
5
Show member pathways
10.07 IDH1 IDH2

GO Terms for Cytogenetically Normal Acute Myeloid Leukemia

Biological processes related to Cytogenetically Normal Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.73 CEBPA KMT2A NPM1 WT1
2 transcription by RNA polymerase II GO:0006366 9.62 CEBPA KMT2A NPM1 WT1
3 positive regulation of transcription, DNA-templated GO:0045893 9.56 CEBPA KMT2A NPM1 WT1
4 negative regulation of cell proliferation GO:0008285 9.46 CEBPA KMT2A NPM1 WT1
5 tricarboxylic acid cycle GO:0006099 9.4 IDH1 IDH2
6 2-oxoglutarate metabolic process GO:0006103 9.37 IDH1 IDH2
7 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
8 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Cytogenetically Normal Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.55 CEBPA FLT3 IDH1 KMT2A NPM1
2 transcription regulatory region DNA binding GO:0044212 9.43 CEBPA KMT2A WT1
3 NAD binding GO:0051287 9.37 IDH1 IDH2
4 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.32 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Cytogenetically Normal Acute Myeloid Leukemia

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