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MCID: CYT002
MIFTS: 46

Cytokine Deficiency

Categories: Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cytokine Deficiency

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MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 53
Cytokine 17

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


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Summaries for Cytokine Deficiency

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MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and dermatitis. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Fluticasone and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and monocytes, and related phenotype is digestive/alimentary.

Wikipedia : 75 Cytokines are a broad and loose category of small proteins (~5-20 kDa) that are important in cell... more...

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Related Diseases for Cytokine Deficiency

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Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2474)
# Related Disease Score Top Affiliating Genes
1 asthma 31.4 IL9 IL5 IL13
2 dermatitis 30.6 IL5 IL13
3 proteasome-associated autoinflammatory syndrome 1 30.5 IL5 IL13
4 sarcoidosis 1 30.2 IL9 IL13
5 leishmaniasis 30.2 IL5 IL13
6 pneumonia 30.2 IL5 IL13
7 hypereosinophilic syndrome 30.2 IL5 IL13
8 dermatitis, atopic 30.1 IL5 IL13
9 rhinitis 30.0 IL5 IL13
10 tetanus 29.9 IL5 IL13
11 cutaneous leishmaniasis 29.9 IL5 IL13
12 conjunctivitis 29.8 IL5 IL13
13 bronchiolitis 29.8 IL5 IL13
14 esophagitis 29.8 IL5 IL13
15 allergic rhinitis 29.8 IL5 IL13
16 allergic hypersensitivity disease 29.7 IL9 IL5 IL13
17 keratoconjunctivitis 29.7 IL5 IL13
18 allergic asthma 29.7 IL9 IL5 IL13
19 trichuriasis 29.7 IL9 IL13
20 food allergy 29.7 IL5 IL13
21 lung disease 29.7 IL5 IL13
22 pulmonary eosinophilia 29.6 IL5 IL13
23 ige responsiveness, atopic 29.6 IL9 IL5 IL13
24 pollen allergy 29.6 IL5 IL13
25 allergic conjunctivitis 29.5 IL5 IL13
26 vernal keratoconjunctivitis 29.5 IL5 IL13
27 esophagitis, eosinophilic, 1 29.5 IL5 IL13
28 common cold 29.5 IL5 IL13
29 respiratory allergy 29.4 IL5 IL13
30 skin disease 29.4 IL5 IL13
31 peanut allergy 29.4 IL9 IL13
32 radiculopathy 29.4 IL5 IL13
33 malaria 29.4 IL9 IL5 IL13
34 stevens-johnson syndrome/toxic epidermal necrolysis 29.4 IL5 IL13
35 onchocerciasis 29.3 IL5 IL13
36 ascaris lumbricoides infection 29.3 IL5 IL13
37 eosinophilic pneumonia 29.2 IL5 IL13
38 intestinal schistosomiasis 29.1 IL5 IL13
39 trichinosis 29.1 IL9 IL5
40 eosinophilic meningitis 29.0 IL5 IL13
41 schistosomiasis 29.0 IL5 IL13
42 conjunctival disease 29.0 IL5 IL13
43 angioimmunoblastic lymphadenopathy with dysproteinemia 28.9 IL5 IL13
44 nickel allergic contact dermatitis 28.9 IL5 IL13
45 strongyloidiasis 28.9 IL5 IL13
46 parasitic helminthiasis infectious disease 28.8 IL5 IL13
47 respiratory syncytial virus infectious disease 28.7 IL5 IL13
48 paragonimiasis 28.7 IL5 IL13
49 angiostrongyliasis 28.7 IL5 IL13
50 latex allergy 28.7 IL5 IL13

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency
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Symptoms & Phenotypes for Cytokine Deficiency

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MGI Mouse Phenotypes related to Cytokine Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9
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Drugs & Therapeutics for Cytokine Deficiency

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Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 977)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
2
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
3
Desogestrel Approved Phase 4 54024-22-5 40973
4
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
5
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
6
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
7
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
8
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
9
Dinoprostone Approved Phase 4 363-24-6 5280360
10
Oxaliplatin Approved, Investigational Phase 4 61825-94-3 5310940 9887054 43805 6857599
11
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
12
Omalizumab Approved, Investigational Phase 4 242138-07-4
13
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
14
Oxacillin Approved, Investigational Phase 4 66-79-5 6196
15
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
16
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
17
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
18
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
19
Metformin Approved Phase 4 657-24-9 4091 14219
20
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
21
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
22
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
23
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
24
Calcium carbonate Approved, Investigational Phase 4 471-34-1
25
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
26
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
27
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
28
Nifedipine Approved Phase 4 21829-25-4 4485
29
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
30
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
31
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
32
Haloperidol Approved Phase 4 52-86-8 3559
33
Clonidine Approved Phase 4 4205-90-7 2803
34
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
35
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 6474909
36
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
37
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
38
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
39
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
40
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
41
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4 90-89-1 3052
42
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
43
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
44
Protein C Approved Phase 4
45
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
46
Fluorometholone Approved, Investigational Phase 4 426-13-1 9878
47
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
48
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
49
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
50
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545

Interventional clinical trials:

(show top 50) (show all 2917)
# Name Status NCT ID Phase Drugs
1 Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations Unknown status NCT01213667 Phase 4 Ranibizumab
2 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
3 Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR Unknown status NCT00289679 Phase 4
4 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
5 Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Were Treated With H.P. Acthar Gel After an Incomplete Response to Combinations of DMARDs and Biologic DMRADs Unknown status NCT03082573 Phase 4 H.P. Acthar gel
6 Mechanisms of Endotoxin-Tolerance of Human Monocytes After CABG-Sugery - Effects of Hemofiltration and Mannitol Treatment Unknown status NCT00426192 Phase 4 i.v. mannitol
7 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
8 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
9 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
10 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
11 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
12 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
13 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
14 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
15 The Safety and Efficacy of Etanercept in Treating Patient With Acute ST Segment Elevated Myocardial Infarction Unknown status NCT01372930 Phase 4 Etanercept;saline
16 Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients Unknown status NCT01417273 Phase 4 Drug: placebo
17 Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
18 Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis Unknown status NCT02796794 Phase 4
19 Asthma and Vitamin D (a Clinical Pilot Study) Unknown status NCT00712205 Phase 4 Placebo;Calcitriol
20 Short Term Diet Intervention in Newly Diagnosed Type 2 Diabetes. a Randomised, Multicentric, Controlled, Clinical Trial Unknown status NCT01409330 Phase 4
21 A Randomised Placebo Controlled Trial. The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
22 Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness in Type 2 Diabetes Patient With Metabolic Syndrome (Randomized, Double-Blind, Placebo-Controled, Cross-Over Study) Unknown status NCT00573950 Phase 4 cilostazol;Placebo
23 Phase 4 Study of the Efficacy of Intralipid Treatment in Patients With Recurrent Implantation Failure and Miscarriages With High Peripheral and Uterine Natural Killer Cells Unknown status NCT01679561 Phase 4 intralipid
24 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
25 Immunological Mechanisms of Oralair® (5 Grass Mix Sublingual Allergen Immunotherapy Tablet) in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
26 The Effects of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring (NuvaRing®) on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
27 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
28 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission: a Prospective, Pilot Study. Unknown status NCT03244709 Phase 4 Tocilizumab
29 Rifaximin Reduces the Complications of Decompensated Cirrhosis Unknown status NCT02190357 Phase 4 Rifaximin
30 Effects of the Use of "de Novo" Everolimus for the Expression of Cytokines in Kidneys From Extended Criteria Donors and With Delayed Graft Function Unknown status NCT01663805 Phase 4 Everolimus
31 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
32 Comparison the Efficacy and Safety of 0.1% Tacrolimus Ointment With 0.1% Mometasone Furoate Cream in the Treatment of Adult Vitiligo: A Single Blinded Pilot Study Unknown status NCT01333410 Phase 4 tacrolimus ointment;Mometasone furoate
33 Rifaximin Predicts the Complications of Decompensated Cirrhosis: a Randomized Controlled Trial Unknown status NCT02074280 Phase 4 rifaximin
34 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
35 Recurrent Urinary Tract Infections in Children: Bacterial Identification, Antibiotic Susceptibility Profiling and Cytokine Levels Associated With Antibiotic Prophylaxis Unknown status NCT02357758 Phase 4 Antibiotic Prophylaxis
36 Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma Unknown status NCT00307606 Phase 4 Solu-medrol 125 mg
37 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
38 Phase 4 Study: Comparison of Myfortic and Early Rapamycin Conversion vs. Low-Dose Tacrolimus in Preventing Acute Rejection and Chronic Allograft Fibrosis: A Protocol Biopsy Directed Approach Unknown status NCT00896012 Phase 4 Rapamune (sirolimus/rapamycin);Tacrolimus
39 Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau Unknown status NCT02953327 Phase 4
40 Phase 4 Clinical Trial to Examine the Role of Rosuvastatin and Exercise Treatment in Modulating Inflammatory Response in Hypercholesterolemic Subjects Unknown status NCT00295373 Phase 4 Rosuvastatin
41 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau Unknown status NCT00168610 Phase 4 Vitamin A
42 A Clinical Study of Biomarkers of Innate and Adaptive Immune Activation Associated With Symptoms and Immune Responses After Administration of a Single Dose of a Quadrivalent Inactivated Split Virus Influenza Vaccine to Healthy Young Adults. Unknown status NCT03160118 Phase 4 Seasonal,quadrivalent,influenza vaccine
43 The Influence of BCG Vaccine as a Booster TDaP-IPV Vaccination: an Explorative Study Unknown status NCT02771782 Phase 4
44 A Multicentre Randomised Trial Of Etanercept And Methotrexate To Induce Remission In Early Inflammatory Arthritis Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
45 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Unknown status NCT02644707 Phase 4
46 A Pilot Study to Evaluate the Efficacy and Safety of Pegylated Interferon Alfa-2b Plus Ribavirin in the Treatment of Patients With Dual Chronic Hepatitis B and Delta Unknown status NCT00117533 Phase 4 pegylated IFN alfa-2b plus ribavirin
47 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
48 Advair - CRP Study Unknown status NCT00120978 Phase 4 Advair;Flovent
49 Safety and Efficacy of Immunosuppression With Basiliximab, Delayed Dose Tacrolimus Plus Enteric Coated Mycophenolic Acid, Versus Standard Dose Tacrolimus, Enteric Coated Mycophenolic Acid Plus Corticosteroids in Patients Undergoing Orthotopic Liver Transplantation (OLT) Unknown status NCT02123108 Phase 4 Basiliximab
50 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D

Search NIH Clinical Center for Cytokine Deficiency

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Genetic Tests for Cytokine Deficiency

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Anatomical Context for Cytokine Deficiency

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MalaCards organs/tissues related to Cytokine Deficiency:

41
T Cells, Lung, Monocytes, Liver, Breast, Endothelial, Bone
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Publications for Cytokine Deficiency

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Articles related to Cytokine Deficiency:

(show top 50) (show all 30019)
# Title Authors PMID Year
1
Di-(2-ethylhexyl)-phthalate interferes with T-follicular helper cell differentiation and cytokine secretion through signaling lymphocytic activation molecule family member-1. 38
31403359 2019
2
5-Aza-2'-deoxycytidine enhances lipopolysaccharide-induced inflammatory cytokine expression in human dental pulp cells by regulating TRAF6 methylation. 38
31117883 2019
3
Cytokine profile, Treg/Th17 cell frequency changes during different posttransplantational time points in patients undergoing renal transplantation. 38
31012117 2019
4
Cytokine-induced expression of nitric oxide synthases in Chlamydia trachomatis-infected spontaneous aborters. 38
29720007 2019
5
Prenatal vanadium exposure, cytokine expression, and fetal growth: A gender-specific analysis in Shanghai MCPC study. 38
31390705 2019
6
Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate. 38
31398463 2019
7
The secreted Ly-6/uPAR related protein-1 (SLURP1) stabilizes epithelial cell junctions and suppresses TNF-α-induced cytokine production. 38
31387745 2019
8
Peripheral anti-inflammatory cytokine Interleukin-10 treatment mitigates interleukin-1β - induced anxiety and sickness behaviors in adult male rats. 38
31195034 2019
9
Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity. 38
30734229 2019
10
Retrograde perfusion in isolated perfused mouse lungs-Feasibility and effects on cytokine levels and pulmonary oedema formation. 38
30925204 2019
11
Gold nanoparticles and polyethylene glycol alleviate clinical symptoms and alter cytokine secretion in a mouse model of experimental autoimmune encephalomyelitis. 38
30957389 2019
12
Cytokine profile as diagnostic and prognostic factor in neonatal sepsis. 38
29562764 2019
13
Polysaccharides from Hedyotis diffusa enhance the antitumor activities of cytokine-induced killer cells. 38
31387180 2019
14
Concentration-dependent cytokine responses of silica nanoparticles and role of ROS in human lung epithelial cells. 38
30861304 2019
15
Cytokine-associated fatigue prior to, during, and post-chemotherapy for breast cancer. 38
31260949 2019
16
RE to manuscript 'In vitro removal of anti-infective agents by a novel cytokine adsorbent system'. 38
31184242 2019
17
Questions to manuscript: 'In vitro removal of anti-infective agents by a novel cytokine adsorbent system'. 38
31190605 2019
18
Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes. 38
31048000 2019
19
Correction for Majumdar et al., "Absence of Receptor Guanylyl Cyclase C Enhances Ileal Damage and Reduces Cytokine and Antimicrobial Peptide Production during Oral Salmonella enterica Serovar Typhimurium Infection". 38
31434761 2019
20
Klotho Ameliorates Cellular Inflammation via Suppression of Cytokine Release and Upregulation of miR-29a in the PBMCs of Diagnosed Alzheimer's Disease Patients. 38
31197641 2019
21
Retrospective follow-up analysis of the transcriptomic patterns of cytokines, cytokine receptors and chemokines at preconception and during pregnancy, in women with post-partum depression. 38
31410161 2019
22
Upregulation of suppressor of cytokine signaling 3 ameliorates spinal degenerative disease in adolescents by mediating leptin and tumor necrosis factor-α levels. 38
31410173 2019
23
Induction effects of Faecalibacterium prausnitzii and its extracellular vesicles on toll-like receptor signaling pathway gene expression and cytokine level in human intestinal epithelial cells. 38
31153056 2019
24
Disease Activity and Patient-Reported Health Measures in Relation to Cytokine Levels in Ankylosing Spondylitis. 38
31147969 2019
25
Cytokine gene polymorphisms among North Indians: Implications for genetic predisposition? 38
31173933 2019
26
Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy. 38
30539293 2019
27
Antibody-cytokine fusion proteins: A novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation. 38
30991144 2019
28
Clinical Utility of Cytokine Biomarker Analysis of Pancreatic Cyst Fluid Obtained by Endoscopic Ultrasound Fine Needle Aspiration: A Pilot Study. 38
31425485 2019
29
Reply from the authors to 'In vitro removal of anti-infective agents by a novel cytokine adsorbent system'. 38
31190604 2019
30
Successful treatment for Kaposi sarcoma inflammatory cytokine syndrome in a severe CD4+ lymphocytopenic HIV patient. 38
31356257 2019
31
Functional characterization of three fish-specific interleukin-23 isoforms as regulators of Th17 signature cytokine expression in grass carp head kidney leukocytes. 38
31202965 2019
32
Effect of S100A8 and S100A9 on expressions of cytokine and skin barrier protein in human keratinocytes. 38
31322196 2019
33
Cytokine fibroblast growth factor 10 (FGF10) polymorphisms are associated with risk of myopia in young children. 38
31021460 2019
34
Employing a glutathione-s-transferase-tag and hyaluronidase to control cytokine retention and release from a hyaluronic acid hydrogel matrix. 38
31387421 2019
35
Predictive value of cervical cytokine, antimicrobial and microflora levels for pre-term birth in high-risk women. 38
31375740 2019
36
Severe cytokine release syndrome after haploidentical peripheral blood transplantation. 38
31394272 2019
37
Piezo1 regulates calcium oscillations and cytokine release from astrocytes. 38
31433095 2019
38
Cytokine Selection of MSC Clones with Different Functionality. 38
31303506 2019
39
Broncho-vaxom alleviates persistent allergic rhinitis in patients by improving Th1/Th2 cytokine balance of nasal mucosa. 38
31403136 2019
40
Alternaria induces airway epithelial cytokine expression independent of protease-activated receptor. 38
31430011 2019
41
Human α defensins promote the expression of the inflammatory cytokine interleukin-8 under high-glucose conditions: Novel insights into the poor healing of diabetic foot ulcers. 38
31158307 2019
42
Cytokine profile and nitric oxide levels in macrophages exposed to Leishmania infantum FML. 38
31128104 2019
43
Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. 38
31427752 2019
44
Suppressors of Cytokine Signaling and Protein Inhibitors of Activated Signal Transducer and Activator of Transcriptions As Therapeutic Targets in Flavivirus Infections. 38
31436502 2019
45
Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis. 38
31388695 2019
46
The Metabolic Cytokine Adiponectin Inhibits Inflammatory Lung Pathology in Invasive Aspergillosis. 38
31253725 2019
47
Impact of different antimycotics on cytokine levels in an in vitro aspergillosis model in human whole blood. 38
31372914 2019
48
Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells. 38
31112703 2019
49
Aqueous Humour Cytokine Changes with Intravitreal Dexamethasone Implant Injection for Diabetic Macular Edema. 38
31418610 2019
50
Generalized Cytokine Increase in the Setting of a Multisystem Clinical Disorder and Carcinoid Syndrome Associated with a Novel NLRP12 Variant. 38
30788684 2019
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Variations for Cytokine Deficiency

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Expression for Cytokine Deficiency

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Search GEO for disease gene expression data for Cytokine Deficiency.
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Pathways for Cytokine Deficiency

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Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 64
Show member pathways
 13.01 IL9 IL5 IL13
2
Akt Signaling 64
Show member pathways
 12.89 IL9 IL5 IL13
3
Cytokine Signaling in Immune system 66
Show member pathways
 12.84 IL9 IL5 IL13
4
PAK Pathway 64
Show member pathways
 12.79 IL9 IL5 IL13
5
Allograft rejection 37 1
Show member pathways
 12.41 IL9 IL5 IL13
6
T cell receptor signaling pathway 37
Show member pathways
 12.12 IL9 IL5
7
Apoptosis Pathway 71
Show member pathways
 12.01 IL5 IL13
8
IL-17 Family Signaling Pathways 65
Show member pathways
 11.91 IL5 IL13
9
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 11.91 IL9 IL5 IL13
10
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.79 IL9 IL5 IL13
11
MAPK Pathway 71
Show member pathways
 11.63 IL5 IL13
12
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.62 IL9 IL5 IL13
13
Glucocorticoid receptor regulatory network 1
11.44 IL5 IL13
14
Innate Lymphoid Cell Differentiation Pathways 65
11.34 IL9 IL5 IL13
15
Lung fibrosis 1
11.31 IL5 IL13
16
Th2 Differentiation Pathway 65
10.99 IL9 IL5 IL13
17
Cytokines and Inflammatory Response 1
10.92 IL5 IL13
18
G-protein signaling_RhoB regulation pathway 22
10.73 IL9 IL5 IL13
19
Development and heterogeneity of the ILC family 1
10.64 IL9 IL5 IL13
20
G-protein signaling_Rap2B regulation pathway 22
10.56 IL9 IL5 IL13
21
OX40 Pathway 64
10.21 IL9 IL5 IL13
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GO Terms for Cytokine Deficiency

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Cellular components related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 IL9 IL5 IL13

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 IL9 IL5 IL13
2 cytokine-mediated signaling pathway GO:0019221 9.26 IL5 IL13
3 positive regulation of B cell proliferation GO:0030890 8.96 IL5 IL13
4 inflammatory response GO:0006954 8.8 IL9 IL5 IL13

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL9 IL5
2 cytokine receptor binding GO:0005126 8.96 IL9 IL13
3 cytokine activity GO:0005125 8.8 IL9 IL5 IL13
Sources

Sources for Cytokine Deficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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