MCID: CYT002
MIFTS: 39

Cytokine Deficiency

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 54
Cytokine 17

Classifications:



External Ids:

Summaries for Cytokine Deficiency

MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and dermatitis. An important gene associated with Cytokine Deficiency is IL9 (Interleukin 9), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include t cells, lung and bone, and related phenotype is digestive/alimentary.

Wikipedia : 77 Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell... more...

Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1651)
# Related Disease Score Top Affiliating Genes
1 asthma 31.6 IL13 IL5 IL9
2 dermatitis 30.6 IL13 IL5
3 pneumonia 30.2 IL13 IL5
4 leishmaniasis 30.2 IL13 IL5
5 dermatitis, atopic 30.1 IL13 IL5
6 schistosomiasis 30.0 IL13 IL5
7 rhinitis 29.9 IL13 IL5
8 cutaneous leishmaniasis 29.9 IL13 IL5
9 hypereosinophilic syndrome 29.9 IL13 IL5
10 esophagitis 29.9 IL13 IL5
11 bronchiolitis 29.8 IL13 IL5
12 allergic rhinitis 29.8 IL13 IL5
13 malaria 29.7 IL13 IL5 IL9
14 sarcoidosis 1 29.6 IL13 IL9
15 food allergy 29.6 IL13 IL5
16 keratoconjunctivitis 29.6 IL13 IL5
17 allergic asthma 29.6 IL13 IL5 IL9
18 esophagitis, eosinophilic, 1 29.5 IL13 IL5
19 conjunctivitis 29.5 IL13 IL5
20 lung disease 29.5 IL13 IL5
21 pulmonary eosinophilia 29.5 IL13 IL5
22 tetanus 29.4 IL13 IL5
23 vernal keratoconjunctivitis 29.4 IL13 IL5
24 ige responsiveness, atopic 29.4 IL13 IL5 IL9
25 trichuriasis 29.4 IL13 IL9
26 radiculopathy 29.3 IL13 IL5
27 onchocerciasis 29.3 IL13 IL5
28 ascaris lumbricoides infection 29.3 IL13 IL5
29 respiratory allergy 29.3 IL13 IL5
30 allergic hypersensitivity disease 29.3 IL13 IL5 IL9
31 allergic conjunctivitis 29.2 IL13 IL5
32 common cold 29.2 IL13 IL5
33 angioimmunoblastic lymphadenopathy with dysproteinemia 29.1 IL13 IL5
34 eosinophilic meningitis 29.0 IL13 IL5
35 pollen allergy 29.0 IL13 IL5
36 eosinophilic pneumonia 29.0 IL13 IL5
37 peanut allergy 29.0 IL13 IL9
38 skin disease 29.0 IL13 IL5
39 respiratory syncytial virus infectious disease 28.8 IL13 IL5
40 paragonimiasis 28.8 IL13 IL5
41 angiostrongyliasis 28.8 IL13 IL5
42 latex allergy 28.8 IL13 IL5
43 intestinal schistosomiasis 28.8 IL13 IL5
44 urinary schistosomiasis 28.8 IL13 IL5
45 stevens-johnson syndrome/toxic epidermal necrolysis 28.8 IL13 IL5
46 cytokine receptor deficiency 12.3
47 kshv inflammatory cytokine syndrome 12.2
48 graft-versus-host disease 11.6
49 hemophagocytic lymphohistiocytosis 11.5
50 kaposi sarcoma 11.3

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency

Symptoms & Phenotypes for Cytokine Deficiency

MGI Mouse Phenotypes related to Cytokine Deficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9

Drugs & Therapeutics for Cytokine Deficiency

Search Clinical Trials , NIH Clinical Center for Cytokine Deficiency

Genetic Tests for Cytokine Deficiency

Anatomical Context for Cytokine Deficiency

MalaCards organs/tissues related to Cytokine Deficiency:

42
T Cells, Lung, Bone, Liver, Brain, Breast, Heart

Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

(show top 50) (show all 2993)
# Title Authors Year
1
Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. ( 30742679 )
2019
2
Systematic assessment of the clinicopathological prognostic significance of tissue cytokine expression for lung adenocarcinoma based on integrative analysis of TCGA data. ( 31004093 )
2019
3
The Disease Phenotype of Adenomyosis-Affected Women Correlates With Specific Serum Cytokine Profiles. ( 30518300 )
2019
4
Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration. ( 30484347 )
2019
5
ADRB2 suppresses IL-13-induced allergic rhinitis inflammatory cytokine regulated by miR-15a-5p. ( 31104300 )
2019
6
Histamine H4 receptor regulates Th2-cytokine profile through thymic stromal lymphopoietin in allergic rhinitis. ( 30848348 )
2019
7
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study. ( 30981680 )
2019
8
The cytokine profile of women with severe anxiety and depression during pregnancy. ( 30943938 )
2019
9
Comparison of endocrinological and cytokine response to trauma in laparoscopic and conventional appendectomy in patients with acute appendicitis. ( 30511942 )
2019
10
Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. ( 31101752 )
2019
11
Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis). ( 31068244 )
2019
12
Are genetic variations in IL-21-IL-23R-IL-17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? Bayesian hierarchical meta-analysis. ( 30924147 )
2019
13
Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis. ( 30767874 )
2019
14
Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis✰. ( 30777365 )
2019
15
Th1/Th17 cytokine profile is induced by macrophage migration inhibitory factor in peripheral blood mononuclear cells from rheumatoid arthritis patients. ( 30698113 )
2019
16
Evaluation of cytokine profiles in rheumatoid arthritis patients with clinically active disease and normal inflammatory indices. ( 30506404 )
2019
17
Functional MIF promoter haplotypes modulate Th17-related cytokine expression in peripheral blood mononuclear cells from control subjects and rheumatoid arthritis patients. ( 30467094 )
2019
18
Not so crystal clear: observations from a case of crystalline arthritis with cytokine release syndrome (CRS) after chimeric antigen receptor (CAR)-T cell therapy. ( 30291306 )
2019
19
miR-410-3p Suppresses Cytokine Release from Fibroblast-Like Synoviocytes by Regulating NF-κB Signaling in Rheumatoid Arthritis. ( 30242542 )
2019
20
PIM-1 kinase is a novel regulator of proinflammatory cytokine-mediated responses in rheumatoid arthritis fibroblast-like synoviocytes. ( 30204915 )
2019
21
Benzo(a)pyrene Facilitates Dermatophagoides Group 1 (Der f 1)-Induced Epithelial Cytokine Release through Aryl Hydrocarbon Receptor in Asthma. ( 30982974 )
2019
22
Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma. ( 30652675 )
2019
23
Mouse models of severe asthma for evaluation of therapeutic cytokine targeting. ( 30659868 )
2019
24
Smoke Exposure, Cytokine Levels, and Asthma Visits in Children Hospitalized for Bronchiolitis. ( 30530718 )
2019
25
Association of IL-10 and TGF-beta cytokine gene polymorphisms with autoimmune hepatitis. ( 30143451 )
2019
26
Defective cytokine production from monocytes/macrophages of E-beta thalassemia patients in response to Pythium insidiosum infection. ( 30765134 )
2019
27
Crosstalk between cytokine profile, redox, and iron status in β-Thalassemia: relation to frequency/duration of blood transfusion. ( 31032672 )
2019
28
IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury. ( 30641838 )
2019
29
Cytokine Responses in Severe Traumatic Brain Injury: Where There Is Smoke, Is There Fire? ( 29569129 )
2019
30
Circulating soluble levels of MIF in women with breast cancer in the molecular subtypes: relationship with Th17 cytokine profile. ( 31102004 )
2019
31
Inflammatory Breast Cancer Promotes Development of M2 Tumor-associated Macrophages and Cancer Mesenchymal Cells Through a Complex Cytokine Network. ( 31043378 )
2019
32
Alteration of specific cytokine expression patterns in patients with breast cancer. ( 30814616 )
2019
33
Influence of prevention of caffeine citrate on cytokine profile and bronchopulmonary dysplasia in preterm infants with apnea. ( 30961342 )
2019
34
Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy. ( 30316668 )
2019
35
B-cell depletion induces a shift in self antigen specific B-cell repertoire and cytokine pattern in patients with bullous pemphigoid. ( 30837635 )
2019
36
Proinflammatory Cytokine Gene Polymorphisms in Bullous Pemphigoid. ( 31001258 )
2019
37
Clinical Importance of a Cytokine Network in Major Burns. ( 29621119 )
2019
38
Impaired Th17 cell proliferation and decreased pro-inflammatory cytokine production in CXCR3/CXCR4 double-deficient mice of vulvovaginal candidiasis. ( 30656691 )
2019
39
Capillary leak syndrome: a cytokine and catecholamine storm? ( 31010471 )
2019
40
Generalized Cytokine Increase in the Setting of a Multisystem Clinical Disorder and Carcinoid Syndrome Associated with a Novel NLRP12 Variant. ( 30788684 )
2019
41
Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age-related macular degeneration, glaucoma and cataract. ( 30298670 )
2019
42
Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis. ( 30820752 )
2019
43
Cytometric Bead Array (CBA) for Measuring Cytokine Levels in Chagas Disease Patients. ( 30868537 )
2019
44
T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment. ( 31085707 )
2019
45
Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line. ( 30800160 )
2019
46
Myricetin ameliorates cytokine-induced migration and invasion of cholangiocarcinoma cells via suppression of STAT3 pathway. ( 30880773 )
2019
47
Longitudinal analysis of serum cytokine profile among patients with tubercular multifocal serpiginoid choroiditis: a pilot study. ( 30185832 )
2019
48
Associations of cytokine concentrations in aqueous humour with retinal vascular abnormalities and exudation in Coats' disease. ( 30414256 )
2019
49
Hydroalcoholic extract of Tagetes erecta L. flowers, rich in the carotenoid lutein, attenuates inflammatory cytokine secretion and improves the oxidative stress in an animal model of ulcerative colitis. ( 30979660 )
2019
50
Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis. ( 30919886 )
2019

Variations for Cytokine Deficiency

Expression for Cytokine Deficiency

Search GEO for disease gene expression data for Cytokine Deficiency.

Pathways for Cytokine Deficiency

Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 IL13 IL5 IL9
2
Show member pathways
12.89 IL13 IL5 IL9
3
Show member pathways
12.84 IL13 IL5 IL9
4
Show member pathways
12.79 IL13 IL5 IL9
5
Show member pathways
12.41 IL13 IL5 IL9
6
Show member pathways
12.12 IL5 IL9
7
Show member pathways
12.01 IL13 IL5
8
Show member pathways
11.91 IL13 IL5
9
Show member pathways
11.91 IL13 IL5 IL9
10
Show member pathways
11.79 IL13 IL5 IL9
11
Show member pathways
11.63 IL13 IL5
12
Show member pathways
11.62 IL13 IL5 IL9
13 11.44 IL13 IL5
14 11.34 IL13 IL5 IL9
15 11.31 IL13 IL5
16 10.99 IL13 IL5 IL9
17 10.92 IL13 IL5
18 10.73 IL13 IL5 IL9
19 10.64 IL13 IL5 IL9
20 10.56 IL13 IL5 IL9
21 10.21 IL13 IL5 IL9

GO Terms for Cytokine Deficiency

Cellular components related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 IL13 IL5 IL9

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 IL13 IL5 IL9
2 cytokine-mediated signaling pathway GO:0019221 9.32 IL13 IL5
3 positive regulation of B cell proliferation GO:0030890 9.16 IL13 IL5
4 regulation of signaling receptor activity GO:0010469 9.13 IL13 IL5 IL9
5 inflammatory response GO:0006954 8.8 IL13 IL5 IL9

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL5 IL9
2 cytokine receptor binding GO:0005126 8.96 IL13 IL9
3 cytokine activity GO:0005125 8.8 IL13 IL5 IL9

Sources for Cytokine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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