Cytokine Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

Sources

Summaries for Cytokine Deficiency

MalaCards based summary : Cytokine Deficiency is related to angioimmunoblastic lymphadenopathy with dysproteinemia and dermatitis. An important gene associated with Cytokine Deficiency is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include endothelial, t cells and lung, and related phenotype is digestive/alimentary.

Wikipedia : ⁷⁶ Cytokines are a broad and loose category of small proteins (~5�??20 kDa) that are important in cell... more...

Sources

Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Related Disease	Score	Top Affiliating Genes
1	angioimmunoblastic lymphadenopathy with dysproteinemia	10.0	IL13 IL5
2	dermatitis	10.0	IL13 IL5
3	respiratory syncytial virus infectious disease	10.0	IL13 IL5
4	nickel allergic contact dermatitis	10.0	IL13 IL5
5	paragonimiasis	10.0	IL13 IL5
6	angiostrongyliasis	10.0	IL13 IL5
7	inflammatory bowel disease 4	10.0	IL13 IL5
8	apple allergy	10.0	IL13 IL5
9	strongyloidiasis	10.0	IL13 IL5
10	ascaris lumbricoides infection	10.0	IL13 IL5
11	latex allergy	10.0	IL13 IL5
12	eosinophilic meningitis	10.0	IL13 IL5
13	intestinal schistosomiasis	10.0	IL13 IL5
14	schistosomiasis	10.0	IL13 IL5
15	chronic tic disorder	10.0	IL13 IL5
16	chronic conjunctivitis	10.0	IL13 IL5
17	conjunctivitis	10.0	IL13 IL5
18	eosinophilic gastritis	10.0	IL13 IL5
19	vernal keratoconjunctivitis	10.0	IL13 IL5
20	keratoconjunctivitis	10.0	IL13 IL5
21	urinary schistosomiasis	10.0	IL13 IL5
22	esophagitis	10.0	IL13 IL5
23	esophagitis, eosinophilic, 1	10.0	IL13 IL5
24	pollen allergy	10.0	IL13 IL5
25	conjunctival disease	10.0	IL13 IL5
26	night blindness, congenital stationary, type 1a	10.0	IL13 IL5
27	pulmonary eosinophilia	10.0	IL13 IL5
28	stevens-johnson syndrome/toxic epidermal necrolysis	10.0	IL13 IL5
29	paranasal sinus disease	10.0	IL13 IL5
30	eosinophilic pneumonia	10.0	IL13 IL5
31	pneumonia	10.0	IL13 IL5
32	onchocerciasis	10.0	IL13 IL5
33	allergic conjunctivitis	10.0	IL13 IL5
34	nasal cavity disease	10.0	IL13 IL5
35	nose disease	10.0	IL13 IL5
36	common cold	10.0	IL13 IL5
37	respiratory allergy	10.0	IL13 IL5
38	parasitic helminthiasis infectious disease	10.0	IL13 IL5
39	food allergy	10.0	IL13 IL5
40	upper respiratory tract disease	10.0	IL13 IL5
41	cutaneous leishmaniasis	10.0	IL13 IL5
42	leishmaniasis	10.0	IL13 IL5
43	bronchial disease	10.0	IL13 IL5
44	trichuriasis	10.0	IL13 IL9
45	bronchiolitis	10.0	IL13 IL5
46	immune system disease	10.0	IL13 IL5
47	proteasome-associated autoinflammatory syndrome 1	9.9	IL13 IL5
48	tetanus	9.9	IL13 IL5
49	hypereosinophilic syndrome	9.9	IL13 IL5
50	trichinosis	9.9	IL5 IL9

Graphical network of the top 20 diseases related to Cytokine Deficiency:

Sources

Symptoms & Phenotypes for Cytokine Deficiency

MGI Mouse Phenotypes related to Cytokine Deficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.8	IL13 IL5 IL9

Sources

Drugs & Therapeutics for Cytokine Deficiency

Search Clinical Trials , NIH Clinical Center for Cytokine Deficiency

Sources

Genetic Tests for Cytokine Deficiency

Sources

Anatomical Context for Cytokine Deficiency

MalaCards organs/tissues related to Cytokine Deficiency:

⁴¹

Endothelial, T Cells, Lung, Skin

Sources

Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

#	Title	Authors	Year
1	Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis. ( 25888308 )	Delsing C.E....Netea M.G.	2015
2	Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. ( 21482794 )	Ermann J....Glimcher L.H.	2011
3	A shift towards a T cell cytokine deficiency along with an anti-inflammatory/regulatory microenvironment may enable the synthesis of anti-FVIII inhibitors in haemophilia A patients. ( 20846164 )	Chaves DG...Martins-Filho OA	2010
4	Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. ( 18410989 )	Tawara I....Reddy P.	2008
5	Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE. ( 11891780 )		2002
6	Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice. ( 9199446 )	Hobden J.A....Hazlett L.D.	1997

Sources

Genes for Cytokine Deficiency

Genes related to Cytokine Deficiency (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL5	Interleukin 5	Protein Coding	16.21	GeneCards inferred via : Publications (show sections)
2	IL9	Interleukin 9	Protein Coding	16.21	GeneCards inferred via : Publications (show sections)
3	IL13	Interleukin 13	Protein Coding	16.21	GeneCards inferred via : Publications (show sections)

Sources

Variations for Cytokine Deficiency

Sources

Expression for Cytokine Deficiency

Search GEO for disease gene expression data for Cytokine Deficiency.

Sources

Pathways for Cytokine Deficiency

Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.01	IL13 IL5 IL9
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	12.89	IL13 IL5 IL9
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.84	IL13 IL5 IL9
4	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	12.79	IL13 IL5 IL9
5	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.41	IL13 IL5 IL9
6	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.01	IL13 IL5
7	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	11.99	IL5 IL9
8	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	11.91	IL13 IL5
9	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	11.91	IL13 IL5 IL9
10	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	11.79	IL13 IL5 IL9
11	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	11.63	IL13 IL5
12	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.62	IL13 IL5 IL9
13	Glucocorticoid receptor regulatory network ¹	11.44	IL13 IL5
14	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.34	IL13 IL5 IL9
15	Lung fibrosis ¹	11.31	IL13 IL5
16	Th2 Differentiation Pathway ⁶⁵	10.99	IL13 IL5 IL9
17	Cytokines and Inflammatory Response ¹	10.92	IL13 IL5
18	G-protein signaling_RhoB regulation pathway ²²	10.73	IL13 IL5 IL9
19	Development and heterogeneity of the ILC family ¹	10.64	IL13 IL5 IL9
20	G-protein signaling_Rap2B regulation pathway ²²	10.56	IL13 IL5 IL9
21	OX40 Pathway ⁶⁴	10.21	IL13 IL5 IL9

Sources

GO Terms for Cytokine Deficiency

Cellular components related to Cytokine Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	8.8	IL13 IL5 IL9

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.43	IL13 IL5 IL9
2	cytokine-mediated signaling pathway	GO:0019221	9.32	IL13 IL5
3	positive regulation of B cell proliferation	GO:0030890	9.16	IL13 IL5
4	regulation of signaling receptor activity	GO:0010469	9.13	IL13 IL5 IL9
5	inflammatory response	GO:0006954	8.8	IL13 IL5 IL9

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.16	IL5 IL9
2	cytokine receptor binding	GO:0005126	8.96	IL13 IL9
3	cytokine activity	GO:0005125	8.8	IL13 IL5 IL9

Sources

Sources for Cytokine Deficiency

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia