Cytokine Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CYT002 MIFTS: 34	Cytokine Deficiency Categories: Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency ¹⁹

Cytokine ¹⁶ ⁷⁵

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

EFO ¹⁶ EFO_0003786

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Summaries for Cytokine Deficiency

MalaCards based summary: Cytokine Deficiency, also known as cytokine, is related to car t cell therapy-associated cytokine release syndrome and asthma. The drugs Zinc cation and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and nk cells.

Wikipedia: ⁷⁵ Cytokines are a broad and loose category of small proteins (~5-25 kDa) important in cell signaling.... more...

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Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2528)

#	Related Disease	Score
1	car t cell therapy-associated cytokine release syndrome	11.3
2	asthma	11.1
3	immunodeficiency 33	11.0
4	immunodeficiency 92	11.0
5	hemophagocytic lymphohistiocytosis, familial, 1	11.0
6	kshv inflammatory cytokine syndrome	11.0
7	hemophagocytic lymphohistiocytosis	11.0
8	cytokine receptor deficiency	11.0
9	myelofibrosis	11.0
10	mycosis fungoides	10.9
11	granulomatosis with polyangiitis	10.9
12	multicentric castleman disease	10.9
13	immunodeficiency 68	10.9
14	crisponi/cold-induced sweating syndrome 1	10.9
15	autoimmune disease	10.9
16	lymphoproliferative syndrome, x-linked, 2	10.9
17	immunodeficiency 67	10.9
18	immunodeficiency 23	10.9
19	autoimmune disease, multisystem, infantile-onset, 1	10.9
20	immunodeficiency 72 with autoinflammation	10.9
21	janus kinase-3 deficiency	10.9
22	hemophagocytic reticulosis	10.9
23	fatal post-viral neurodegenerative disorder	10.9
24	inflammatory bowel disease-recurrent sinopulmonary infections syndrome	10.9
25	viral infectious disease	10.8
26	adult respiratory distress syndrome	10.8
27	rheumatoid arthritis	10.8
28	covid-19	10.8
29	arthritis	10.7
30	proteasome-associated autoinflammatory syndrome 1	10.7
31	toxic shock syndrome	10.7
32	dermatitis, atopic	10.7
33	severe acute respiratory syndrome	10.7
34	dermatitis	10.7
35	leukemia	10.7
36	periodontitis	10.7
37	inflammatory bowel disease	10.7
38	hepatitis	10.7
39	leptin deficiency or dysfunction	10.7
40	severe covid-19	10.7
41	mycobacterium tuberculosis 1	10.7
42	systemic lupus erythematosus	10.6
43	immune deficiency disease	10.6
44	allergic disease	10.6
45	leishmaniasis	10.6
46	hypereosinophilic syndrome	10.6
47	type 1 diabetes mellitus	10.6
48	lupus erythematosus	10.6
49	multiple sclerosis	10.6
50	severe combined immunodeficiency	10.6

Graphical network of the top 20 diseases related to Cytokine Deficiency:

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Symptoms & Phenotypes for Cytokine Deficiency

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Drugs & Therapeutics for Cytokine Deficiency

Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 349)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Zinc cation

Approved, Experimental, Investigational

Phase 4

7440-66-6, 23713-49-7

32051

Infliximab

Approved

Phase 4

170277-31-3

Fluorouracil

Approved

Phase 4

51-21-8

3385

Oxaliplatin

Approved, Investigational

Phase 4

61825-94-3

43805 11947679 6857599

Fluoxetine

Approved, Vet_approved

Phase 4

54910-89-3

3386

Dexmedetomidine

Approved, Experimental, Vet_approved

Phase 4

86347-14-0, 113775-47-6

68602 5311068

Hydrocortisone succinate

Approved

Phase 4

2203-97-6

3643

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

3640 5754

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Azithromycin

Approved

Phase 4

83905-01-5

447043

Etanercept

Approved, Investigational

Phase 4

185243-69-0

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5, 15307-79-6

3033

Tocopherol

Approved, Investigational

Phase 4

1406-66-2

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

581 12035

Omalizumab

Approved, Investigational

Phase 4

242138-07-4

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Nitroglycerin

Approved, Investigational

Phase 4

55-63-0

4510

Copper

Approved, Investigational

Phase 4

7440-50-8

27099

Nifedipine

Approved

Phase 4

21829-25-4

4485

Iron

Approved

Phase 4

7439-89-6

29936

Amisulpride

Approved, Investigational

Phase 4

71675-85-9, 53583-79-2

2159

Valproic acid

Approved, Investigational

Phase 4

99-66-1

3121

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Clozapine

Approved

Phase 4

5786-21-0

2818 135398737

Imiquimod

Approved, Investigational

Phase 4

99011-02-6

57469

Nitrofurantoin

Approved, Vet_approved

Phase 4

67-20-9

5353830

Trimethoprim

Approved, Vet_approved

Phase 4

738-70-5

5578

Citalopram

Approved

Phase 4

59729-32-7, 59729-33-8

2771

Etoposide

Approved

Phase 4

33419-42-0

36462

Aflibercept

Approved

Phase 4

862111-32-8

124490314

Ranibizumab

Approved

Phase 4

347396-82-1

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

3003 5743

Temozolomide

Approved, Investigational

Phase 4

85622-93-1

5394

Dimercaprol

Approved

Phase 4

59-52-9

3080

Oseltamivir

Approved

Phase 4

204255-11-8, 196618-13-0

65028

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Budesonide

Approved

Phase 4

51333-22-3

5281004 40000 63006

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

Phase 4

59-02-9, 10191-41-0

2116 14985

Ascorbic acid

Approved, Nutraceutical

Phase 4

50-81-7

54676860 54670067 5785

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 4

22737-96-8, 68-26-8

5280382 445354

Interventional clinical trials:

(show top 50) (show all 511)

#	Name	Status	NCT ID	Phase	Drugs
1	Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study	Unknown status	NCT02651168	Phase 4
2	Intraocular Cytokine Changes in Recurrence of Polypoidal Choroidal Vasculopathy	Unknown status	NCT02976194	Phase 4	ranibizumab
3	Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study.	Unknown status	NCT03082469	Phase 4
4	The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils	Unknown status	NCT00673218	Phase 4	Placebo;Xolair
5	Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR	Unknown status	NCT00289679	Phase 4
6	Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels	Unknown status	NCT01115842	Phase 4	Vitamin D
7	The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients	Unknown status	NCT01407211	Phase 4
8	The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients	Unknown status	NCT01414972	Phase 4	Vitamin A;placebo
9	The Effects of Intravitral Ozurdex Implant in DME: Cytokine Change in Aqueous Humor	Unknown status	NCT03475407	Phase 4	Ozurdex intravitreal injection
10	Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations	Unknown status	NCT01213667	Phase 4	Ranibizumab
11	Clinical Efficacy of Chemotherapy Combined With Cytokine-induced Killer in Treatment of Patients With Colon Cancer	Completed	NCT03084809	Phase 4	Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
12	Fluoxetine to Reduce Intubation and Death After COVID19 Infection	Completed	NCT04377308	Phase 4	Fluoxetine
13	The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block on Plasma Cortisol and Pain-related Cytokines After Arthroscopic Rotator Cuff Repair: a Randomized Controlled Trial	Completed	NCT04398589	Phase 4	Dexmedetomidine injection;Saline injection
14	TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience	Completed	NCT04730323	Phase 4	Tocilizumab
15	EFFECTS OF NSAIDs ON CLINICAL OUTCOMES, SYNOVIAL FLUID CYTOKINE CONCENTRATION AND SIGNAL TRANSDUCTION PATHWAYS IN KNEE OSTEOARTHRITIS	Completed	NCT01860833	Phase 4	Ibuprofen;Celecoxib;Diclofenac
16	Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study	Completed	NCT00512265	Phase 4	n-acetylcysteine;250mL glucose 5%
17	The Effect of Xolair (Omalizumab) on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils	Completed	NCT00657891	Phase 4	Omalizumab;Placebo
18	The Effect of Preoperative Topical Ketorolac 0.45% on Aqueous Cytokine Levels and Macular Thickness in Diabetic and Non Diabetic Patients Undergoing Cataract Surgery	Completed	NCT02646072	Phase 4	Ketorolac tromethamine ophthalmic solution 0.45%
19	Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.	Completed	NCT00431691	Phase 4	vitamin and mineral supplement;Escherichia coli Endotoxin (LPS);100% O2;nitroglycerin
20	TNF-α Blockade for Psoriatic Arthritis - A Clinical and MRI Study, and the Effects on Cytokine and Cardiovascular Risk Profile	Completed	NCT00432406	Phase 4	Infliximab;Etanercept
21	The Effect of Zinc, Beta-carotene, and Vitamin D3 Supplementation as Pro-inflammation Mediated Regulator in Preterm Delivery Through Placental Protein Adaptor MyD88 and TRIF, Transcription Factor NFkB, and Pro-inflammatory Cytokine IL-1β	Completed	NCT03005496	Phase 4	Zinc;Nifedipine;Beta Carotene;Vitamin D3;Dexamethasone
22	Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy	Completed	NCT03652974	Phase 4	sodium valproate with Clozapine;amisulpride with Clozapine;placebo with Clozapine
23	A Multi-Center, Open-Label Study Evaluating the Cytokine and Eyelid Margin Bacterial Load Levels of Subjects Diagnosed With Chronic Blepharitis Following Dosing With AzaSite® (Azithromycin Ophthalmic Solution) 1%	Completed	NCT00629941	Phase 4	AzaSite®
24	Preoperative Versus Postoperative Ultrasound-guided Rectus Sheath Block for Improving Pain, Sleep Quality and Cytokine Levels of Patients With Open Midline Incisions Undergoing Transabdominal Gynaecological Operation	Completed	NCT02477098	Phase 4	preoperative 0.5% ropivacaine hydrochloride preoperative;postoperative 0.5% Ropivacaine hydrochloride
25	Phenotype and Cytokine Production Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Aldara 5% Cream Using Flow Cytometry	Completed	NCT00176943	Phase 4	Aldara Cream 5%
26	Recurrent Urinary Tract Infections in Children: Bacterial Identification, Antibiotic Susceptibility Profiling and Cytokine Levels Associated With Antibiotic Prophylaxis	Completed	NCT02357758	Phase 4	Antibiotic Prophylaxis
27	Effect of Preemptive Epidural Analgesia in Labor on Pro and Anti-inflammatory Cytokine Production in a Mother and a Newborn	Completed	NCT00361712	Phase 4	Standard of care
28	The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression	Completed	NCT00254020	Phase 4	Citalopram
29	Effects of Fingolimod (Gilenya®) on Cytokine and Chemokine Levels in Relapsing Remitting Multiple Sclerosis Patients	Completed	NCT02373098	Phase 4	Fingolimod 0.5 mg
30	Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Treatment Naïve Patients With Diabetic Macular Edema	Completed	NCT02441907	Phase 4	aflibercept
31	Anti Cytokine Combination Therapy With Daclizumab and Infliximab for Treatment of Steroid Refractory Acute GVHD	Completed	NCT00574470	Phase 4	daclizumab, infliximab
32	Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement	Completed	NCT01399268	Phase 4	Hydrocortisone;Saline
33	Robust Antibody and Cytokine Response to Hepatitis B Vaccine Among Not-in-treatment Patients With Chronic Hepatitis C：An Open-label Control Study in China	Completed	NCT02898922	Phase 4
34	Clinical Study on the Treatment of Pediatric Hemophagocytic Lymphohistiocytosis Based on Cytokine Guided Risk Stratification：A Multicenter Randomized Controlled Study	Recruiting	NCT05491304	Phase 4	Dexamethasone;Etoposide;Ruxolitinib
35	Cytokine and Visual Outcome Variations in Eyes Receiving a Variable Dosing Ranibizumab Treatment: The COVERT Study	Recruiting	NCT03056092	Phase 4	Intravitreal ranibizumab
36	Cytokine and Visual Outcome Variations in Eyes Receiving a Variable Dosing Aflibercept Treatment: The COVARIANT Study	Recruiting	NCT03056079	Phase 4	Intravitreal aflibercept
37	The Pharmacokinetics of Aqueous Dexamethasone and the Inflammatory Cytokine Response After Treatment With a Dexamethasone Intracanalicular Insert - The CYTODEX Study	Active, not recruiting	NCT04667507	Phase 4	Dexamethasone Ophthalmic implant
38	A Study of CIK in Combination With Temozolomide With and Without Radiation in Adults With Advanced Malignant Gliomas	Not yet recruiting	NCT02496988	Phase 4	Temozolomide
39	A Randomized, Open Label Study to Evaluate the Effect of Tamiflu on Viral Shedding and on Serum and Cytoplasmic Inflammatory Cytokine Concentrations in Patients With Laboratory-confirmed Influenza	Terminated	NCT00436124	Phase 4	oseltamivir [Tamiflu]
40	Comparison Between Ceftriaxone and Levofloxacin on Cytokine Expression Over Time in Severe Pneumococcal Pneumonia	Terminated	NCT00429975	Phase 4	levofloxacin;ceftriaxone
41	Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants	Terminated	NCT00146497	Phase 4	Budesonide-Surfactant
42	Propofol Versus Midazolam for Sedation in Mechanically Ventilated Critically Ill Patients Who Presented With Traumatic Brain Injury: Cytokine Response and Neuropsychological Assessment (IRRC#1201M)	Terminated	NCT01712477	Phase 4	Intravenous sedation using propofol;Intravenous sedation with midazolam
43	Comparison of the Treatment Efficacy of High-Dose Corticosteroid and Tocilizumab During Clinical Worsening in Patients With COVID-19 Pneumonia	Withdrawn	NCT05133635	Phase 4	Methylprednisolone;Tocilizumab
44	Impact of Statins on Cytokine Expression in Pneumonia	Withdrawn	NCT00946166	Phase 4	simvastatin;Placebo
45	To Determine the Efficacy of Neurokinin 1 Receptor Antagonist as a Therapeutic Tool Against Cytokine Storm and Respiratory Failure in Covid-19 Patients	Unknown status	NCT04468646	Phase 3	NK-1R antagonist
46	Anti-inflammatory/Antioxidant Oral Nutrition Supplementation on the Cytokine Storm and Progression of COVID-19: A Randomized Controlled Trial	Unknown status	NCT04323228	Phase 2, Phase 3
47	The Effectiveness and Safety of Adjuvant Cytokine-induced Killer Cell Immunotherapy for Stage III Colorectal Cancer Patients After Chemotherapy	Unknown status	NCT02280278	Phase 3	Adjuvant chemotherapy
48	Single Center, Prospective, Randomized, Partly-Double Blinded, Controlled Trial to Assess the Safety and Feasibility of Intracoronary Cell Infusion Mobilized With G-CSF and Darbepoetin and Their Effects on Improvement of Cardiac Function in Patients With Myocardial Infarction: Myocardial Regeneration and Angiogenesis in Myocardial Infarction With G-CSF and Erythropoietin Mobilization and Intra-Coronary Cell Infusion -5-Combination Cytokine Therapy Trial	Unknown status	NCT00501917	Phase 2, Phase 3	G-CSF with/without darbepoetin, peripheral blood stem cell infusion
49	Evaluation of Cytokine-induced Killer (CIK) Cells as Therapy or Adjuvant Treatment for Patients With Advanced Hepatocelluler Carcinoma	Unknown status	NCT02568748	Phase 3
50	Maintenance Immunotherapy With Autologous Cytokine-induced Killer Cells for Stage IIIb/IV Nonsquamous Non-small Cell Lung Cancer	Unknown status	NCT01481259	Phase 2, Phase 3

Search NIH Clinical Center for Cytokine Deficiency

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Genetic Tests for Cytokine Deficiency

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Anatomical Context for Cytokine Deficiency

Organs/tissues related to Cytokine Deficiency:

MalaCards : T Cells, Bone Marrow, Nk Cells, Lung, Endothelial, Liver, Smooth Muscle

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Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

(show top 50) (show all 30021)

#	Title	Authors	PMID	Year
1	Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis. ⁶²	Wang H...Hu Y	36185750	2023
2	Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains. ⁶²	da Silva ASM...Antas PRZ	34766868	2022
3	Tanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms by inhibiting Th2 cytokine production and mast cell histamine release in mice. ⁶²	Chen Q...Chen H	35167426	2022
4	A Systematic Review of Inflammatory Cytokine Changes Following Aneurysmal Subarachnoid Hemorrhage in Animal Models and Humans. ⁶²	Devlin P...Stanfill AG	35260989	2022
5	Comprehensive analysis of cytokine adsorption properties of polymethyl methacrylate (PMMA) membrane material. ⁶²	Kishikawa T...Sakaguchi H	35301606	2022
6	Natural products and their derivatives as immune check point inhibitors: Targeting cytokine/chemokine signalling in cancer. ⁶²	Gupta M...Sarwat M	35772610	2022
7	Extracellular DNA levels and cytokine profiles in preterm birth: a cohort study. ⁶²	Krasnyi AM...Krechetova LV	35218368	2022
8	Preincubation of donor tissue with a VEGF cytokine trap promotes subsequent high-risk corneal transplant survival. ⁶²	Zhang W...Bock F	34810177	2022
9	Evaluation of periodontal status and cytokine levels in saliva and gingival crevicular fluid of patients with inflammatory bowel diseases. ⁶²	Enver A...Silva APBD	35665507	2022
10	Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection. ⁶²	Dorflinger B...Hacker G	35505004	2022
11	Multiple Cytokine Analysis of Th1/Th2/Th9/Th17/Th22/Treg Cytokine Pathway for Individual Immune Profile Assessment in Patients with Psoriasis. ⁶²	Michalak-Stoma A...Chodorowska G	36419330	2022
12	A novel oncolytic virus induces a regional cytokine storm and safely eliminates malignant ascites of colon cancer. ⁶²	Dong S...Zhou F	35510373	2022
13	The impact of HCV eradication on hyperglycemia, insulin resistance, cytokine production, and insulin receptor substrate-1 and 2 expression in patients with HCV infection. ⁶²	Mahmoud B...Mabrouk D	34757525	2022
14	Cell division cycle 42 positively correlates with T helper 2 cytokine, effusion viscosity, and hearing loss degree in otitis media with effusion patients. ⁶²	Wu D...Duan C	36164754	2022
15	Can the hyperthermia-mediated heat shock factor/heat shock protein 70 pathway dampen the cytokine storm during SARS-CoV-2 infection? ⁶²	Rebe C...Garrido C	33314076	2022
16	Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19. ⁶²	Talarico LB...Lopez EL	36102684	2022
17	Interleukin-6 Antagonists: Lessons From Cytokine Release Syndrome to the Therapeutic Application in Severe COVID-19 Infection. ⁶²	Meanwatthana J...Majam T	33759631	2022
18	Association of Pregnancy With Coronavirus Cytokine Storm: Systematic Review and Meta-analysis. ⁶²	Muthuka J...Nyamai EM	35319475	2022
19	From Cytokine Storm to Cytokine Breeze: Did Lessons Learned from Immunopathogenesis Improve Immunomodulatory Treatment of Moderate-to-Severe COVID-19? ⁶²	Rondovic G...Surbatovic M	36289881	2022
20	Relationship between cytokine storm and SARS-CoV-2 infection's worsening. ⁶²	Guermouche B...Merzouk H	35135040	2022
21	Exploring the angiographic-biologic phenotype in the IMAGINE study: quantitative UWFA and cytokine expression. ⁶²	Abraham JR...Ehlers JP	34099465	2022
22	SARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach. ⁶²	Barh D...Tambuwala MM	36215001	2022
23	Severity of Cytokine Release Syndrome Influences Outcome After Axicabtagene Ciloleucel for Large B cell Lymphoma: Results from the US Lymphoma CAR-T Consortium. ⁶²	Jacobs MT...Locke FL	35780055	2022
24	Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach. ⁶²	Aliyu M...Azizi G	35969896	2022
25	Acupuncture and its effect on cytokine and chemokine profiles in seasonal allergic rhinitis: a preliminary three-armed, randomized, controlled trial. ⁶²	Gellrich D...Groger M	35301577	2022
26	Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma. ⁶²	Khalfaoui L...Bradding P	35579040	2022
27	Zinc Oxide Tetrapods Modulate Wound Healing and Cytokine Release In Vitro-A New Antiproliferative Substance in Glaucoma Filtering Surgery. ⁶²	Sonntag SR...Nassar K	36362846	2022
28	Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition. ⁶²	Jain V...Singh N	34369317	2022
29	Increased cytokine gene expression and cognition risk associated with androgen deprivation therapy. ⁶²	Verma S...Gupta S	35821621	2022
30	Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axis. ⁶²	Mohammadisoleimani E...Mansoori Y	35989496	2022
31	Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis. ⁶²	Howe AS...Lynch DA	35880170	2022
32	Envelope-based partial partial least squares with application to cytokine-based biomarker analysis for COVID-19. ⁶²	Park Y...Chung D	36111618	2022
33	Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model. ⁶²	Walweel K...Fraser JF	34666219	2022
34	Ascorbic acid attenuates activation and cytokine production in sepsis-like monocytes. ⁶²	Schmidt T...Kahn F	35141934	2022
35	Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries. ⁶²	Arhontoulis DC...Mei Y	35689600	2022
36	Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections. ⁶²	Wang Y...Liu J	35792186	2022
37	IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. ⁶²	Clement M...Humphreys IR	36075894	2022
38	Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy. ⁶²	Walle T...Ungerechts G	35715501	2022
39	Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive. ⁶²	Meermeier EW...Lewinsohn DM	36085311	2022
40	Cytokine Mixtures Mimicking the Local Milieu in Patients with Inflammatory Bowel Disease Impact Phenotype and Function of Mesenchymal Stromal Cells. ⁶²	Barnhoorn MC...Schepers K	35984079	2022
41	Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19. ⁶²	Diorio C...Teachey DT	35705524	2022
42	Comparative evaluation of host immune response and cytokine signature pertaining to Th1 and Th2 immune arms in serum and tissue among patients of acute localised vs. chronic disseminated dermatophytosis. ⁶²	Patel N...Babaria S	35673954	2022
43	Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19. ⁶²	Tsagkaris C...Kamal MA	36089786	2022
44	Cytokine profile in tear and aqueous humor of primary open-angle patients as a prognostic factor for trabeculectomy outcome. ⁶²	Burgos-Blasco B...Martinez-de-la-Casa JM	34812085	2022
45	Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder. ⁶²	Casey S...SCOPE Consortium	34505185	2022
46	Cytokine Receptor Diversity in the Lamprey Predicts the Minimal Essential Cytokine Networks of Vertebrates. ⁶²	Boulay JL...Cooper MD	35914837	2022
47	Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19. ⁶²	Laurent P...Barrat FJ	36083891	2022
48	A Mendelian randomization cytokine screen reveals IL-13 as causal factor in risk of severe COVID-19. ⁶²	Kamali Z...Snieder H	35618154	2022
49	Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease. ⁶²	Vakil MK...Ghasemian A	35538614	2022
50	Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19. ⁶²	Ravichandran S...Kandasamy M	35721801	2022