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MCID: CYT002
MIFTS: 44

Cytokine Deficiency

Categories: Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cytokine Deficiency

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MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 52
Cytokine 17

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


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Summaries for Cytokine Deficiency

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MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and proteasome-associated autoinflammatory syndrome 1. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Fluticasone and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and monocytes, and related phenotype is digestive/alimentary.

Wikipedia : 74 Cytokines are a broad and loose category of small proteins (~5-20 kDa) that are important in cell... more...

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Related Diseases for Cytokine Deficiency

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Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2465)
# Related Disease Score Top Affiliating Genes
1 asthma 31.4 IL9 IL5 IL13
2 proteasome-associated autoinflammatory syndrome 1 30.5 IL5 IL13
3 dermatitis 30.4 IL5 IL13
4 leishmaniasis 30.2 IL5 IL13
5 autoimmune disease 30.2 IL9 IL5 IL13
6 ige responsiveness, atopic 30.1 IL5 IL13
7 sarcoidosis 1 30.1 IL9 IL13
8 lymphoma, hodgkin, classic 30.1 IL9 IL13
9 mastocytosis 30.0 IL9 IL13
10 severe combined immunodeficiency, x-linked 29.9 IL9 IL13
11 dermatitis, atopic 29.9 IL9 IL5 IL13
12 allergic contact dermatitis 29.9 IL9 IL5
13 bronchiolitis 29.9 IL5 IL13
14 cutaneous leishmaniasis 29.9 IL5 IL13
15 hypereosinophilic syndrome 29.9 IL9 IL5 IL13
16 rhinitis 29.8 IL9 IL5 IL13
17 severe combined immunodeficiency 29.8 IL9 IL5 IL13
18 conjunctivitis 29.8 IL5 IL13
19 allergic rhinitis 29.8 IL9 IL5 IL13
20 allergic asthma 29.8 IL9 IL5 IL13
21 allergic hypersensitivity disease 29.8 IL9 IL5 IL13
22 lung disease 29.8 IL9 IL5 IL13
23 chronic fatigue syndrome 29.8 IL5 IL13
24 inflammatory bowel disease 29.7 IL9 IL5 IL13
25 esophagitis 29.7 IL5 IL13
26 keratoconjunctivitis 29.7 IL5 IL13
27 food allergy 29.7 IL5 IL13
28 multiple sclerosis 29.7 IL9 IL5 IL13
29 tetanus 29.6 IL9 IL5 IL13
30 pulmonary disease, chronic obstructive 29.6 IL9 IL5 IL13
31 filarial elephantiasis 29.6 IL5 IL13
32 urticaria 29.6 IL5 IL13
33 pulmonary eosinophilia 29.5 IL5 IL13
34 pollen allergy 29.5 IL5 IL13
35 allergic conjunctivitis 29.5 IL5 IL13
36 trichuriasis 29.5 IL9 IL13
37 vernal keratoconjunctivitis 29.5 IL5 IL13
38 bullous pemphigoid 29.5 IL5 IL13
39 diphtheria 29.5 IL5 IL13
40 common cold 29.5 IL5 IL13
41 castleman disease 29.4 IL9 IL5
42 interstitial lung disease 29.4 IL5 IL13
43 esophagitis, eosinophilic, 1 29.4 IL5 IL13
44 stevens-johnson syndrome/toxic epidermal necrolysis 29.4 IL5 IL13
45 pulmonary fibrosis, idiopathic 29.4 IL9 IL5 IL13
46 malaria 29.3 IL9 IL5 IL13
47 bronchitis 29.3 IL9 IL5 IL13
48 onchocerciasis 29.3 IL5 IL13
49 ascaris lumbricoides infection 29.2 IL5 IL13
50 intrinsic asthma 29.2 IL5 IL13

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency
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Symptoms & Phenotypes for Cytokine Deficiency

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MGI Mouse Phenotypes related to Cytokine Deficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9
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Drugs & Therapeutics for Cytokine Deficiency

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Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 976)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
2
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
3
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
4
Desogestrel Approved Phase 4 54024-22-5 40973
5
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
6
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
7
Dinoprostone Approved Phase 4 363-24-6 5280360
8
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
9
Methyltestosterone Approved Phase 4 58-18-4 6010
10
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
11
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
12
Testosterone enanthate Approved Phase 4 315-37-7 9416
13
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
14
Omalizumab Approved, Investigational Phase 4 242138-07-4
15
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
16
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
17
Oxacillin Approved, Investigational Phase 4 66-79-5 6196
18
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
19
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
20
Etanercept Approved, Investigational Phase 4 185243-69-0
21
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
22
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
23
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
24
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
25
Calcium carbonate Approved, Investigational Phase 4 471-34-1
26
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
27
Silver sulfadiazine Approved, Vet_approved Phase 4 22199-08-2 441244
28 silver nitrate Approved, Investigational Phase 4
29
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
30
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
31
Metformin Approved Phase 4 657-24-9 4091 14219
32
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
33 Brodalumab Approved, Investigational Phase 4 1174395-19-7
34
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
35
Nifedipine Approved Phase 4 21829-25-4 4485
36
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
37
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
38
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
39
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 6474909
40
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
41
Haloperidol Approved Phase 4 52-86-8 3559
42
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
43
Clonidine Approved Phase 4 4205-90-7 2803
44
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
45
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
46
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
47
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
48
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
49
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
50
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4 90-89-1 3052

Interventional clinical trials:

(show top 50) (show all 3009)
# Name Status NCT ID Phase Drugs
1 Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations Unknown status NCT01213667 Phase 4 Ranibizumab
2 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
3 Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR Unknown status NCT00289679 Phase 4
4 Mechanisms of Endotoxin-Tolerance of Human Monocytes After CABG-Sugery - Effects of Hemofiltration and Mannitol Treatment Unknown status NCT00426192 Phase 4 i.v. mannitol
5 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
6 Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Were Treated With H.P. Acthar Gel After an Incomplete Response to Combinations of DMARDs and Biologic DMRADs Unknown status NCT03082573 Phase 4 H.P. Acthar gel
7 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
8 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
9 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
10 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
11 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
12 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
13 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
14 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
15 Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients Unknown status NCT01417273 Phase 4 Drug: placebo
16 Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
17 The Safety and Efficacy of Etanercept in Treating Patient With Acute ST Segment Elevated Myocardial Infarction Unknown status NCT01372930 Phase 4 Etanercept;saline
18 Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis Unknown status NCT02796794 Phase 4
19 Asthma and Vitamin D (a Clinical Pilot Study) Unknown status NCT00712205 Phase 4 Placebo;Calcitriol
20 Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness in Type 2 Diabetes Patient With Metabolic Syndrome (Randomized, Double-Blind, Placebo-Controled, Cross-Over Study) Unknown status NCT00573950 Phase 4 cilostazol;Placebo
21 Phase 4 Study of the Efficacy of Intralipid Treatment in Patients With Recurrent Implantation Failure and Miscarriages With High Peripheral and Uterine Natural Killer Cells Unknown status NCT01679561 Phase 4 intralipid
22 Short Term Diet Intervention in Newly Diagnosed Type 2 Diabetes. a Randomised, Multicentric, Controlled, Clinical Trial Unknown status NCT01409330 Phase 4
23 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
24 Immunological Mechanisms of Oralair® (5 Grass Mix Sublingual Allergen Immunotherapy Tablet) in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
25 The Effects of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring (NuvaRing®) on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
26 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
27 Rifaximin Reduces the Complications of Decompensated Cirrhosis Unknown status NCT02190357 Phase 4 Rifaximin
28 Rifaximin Predicts the Complications of Decompensated Cirrhosis: a Randomized Controlled Trial Unknown status NCT02074280 Phase 4 rifaximin
29 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
30 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission: a Prospective, Pilot Study. Unknown status NCT03244709 Phase 4 Tocilizumab
31 Effects of the Use of "de Novo" Everolimus for the Expression of Cytokines in Kidneys From Extended Criteria Donors and With Delayed Graft Function Unknown status NCT01663805 Phase 4 Everolimus
32 Comparison the Efficacy and Safety of 0.1% Tacrolimus Ointment With 0.1% Mometasone Furoate Cream in the Treatment of Adult Vitiligo: A Single Blinded Pilot Study Unknown status NCT01333410 Phase 4 tacrolimus ointment;Mometasone furoate
33 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
34 Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma Unknown status NCT00307606 Phase 4 Solu-medrol 125 mg
35 Granulocyte Colony Stimulating Factor Plus N-Acetyl Cysteine In Severe Alcoholic Hepatitis Unknown status NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
36 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
37 Phase 4 Study: Comparison of Myfortic and Early Rapamycin Conversion vs. Low-Dose Tacrolimus in Preventing Acute Rejection and Chronic Allograft Fibrosis: A Protocol Biopsy Directed Approach Unknown status NCT00896012 Phase 4 Rapamune (sirolimus/rapamycin);Tacrolimus
38 Phase 4 Clinical Trial to Examine the Role of Rosuvastatin and Exercise Treatment in Modulating Inflammatory Response in Hypercholesterolemic Subjects Unknown status NCT00295373 Phase 4 Rosuvastatin
39 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau Unknown status NCT00168610 Phase 4 Vitamin A
40 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Unknown status NCT02644707 Phase 4
41 A Clinical Study of Biomarkers of Innate and Adaptive Immune Activation Associated With Symptoms and Immune Responses After Administration of a Single Dose of a Quadrivalent Inactivated Split Virus Influenza Vaccine to Healthy Young Adults. Unknown status NCT03160118 Phase 4 Seasonal,quadrivalent,influenza vaccine
42 Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau Unknown status NCT02953327 Phase 4
43 The Influence of BCG Vaccine as a Booster TDaP-IPV Vaccination: an Explorative Study Unknown status NCT02771782 Phase 4
44 A Pilot Study to Evaluate the Efficacy and Safety of Pegylated Interferon Alfa-2b Plus Ribavirin in the Treatment of Patients With Dual Chronic Hepatitis B and Delta Unknown status NCT00117533 Phase 4 pegylated IFN alfa-2b plus ribavirin
45 The Impact of Conventional Hemodialysis, High Flux Hemodialysis and Hemodiafiltration on Adiponectin, Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
46 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
47 Advair - CRP Study Unknown status NCT00120978 Phase 4 Advair;Flovent
48 Safety and Efficacy of Immunosuppression With Basiliximab, Delayed Dose Tacrolimus Plus Enteric Coated Mycophenolic Acid, Versus Standard Dose Tacrolimus, Enteric Coated Mycophenolic Acid Plus Corticosteroids in Patients Undergoing Orthotopic Liver Transplantation (OLT) Unknown status NCT02123108 Phase 4 Basiliximab
49 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
50 Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) Unknown status NCT02798068 Phase 4 Solu-medrol or placebo administration

Search NIH Clinical Center for Cytokine Deficiency

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Genetic Tests for Cytokine Deficiency

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Anatomical Context for Cytokine Deficiency

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MalaCards organs/tissues related to Cytokine Deficiency:

40
T Cells, Lung, Monocytes, Liver, Breast, Endothelial, Bone
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Publications for Cytokine Deficiency

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Articles related to Cytokine Deficiency:

(show top 50) (show all 30019)
# Title Authors PMID Year
1
Protein microarray analysis of cytokine expression changes in distal stumps after sciatic nerve transection. 61
31571662 2020
2
Clinical correlation of liver function tests with suppression of cytokine signaling (SOCS1) gene expression in HCV infected patients: A real-world clinical experience. 61
31535716 2020
3
Cytokine secretion in breast cancer cells - MILLIPLEX assay data. 61
31828190 2020
4
Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial. 61
31707049 2020
5
Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast. 61
31004803 2020
6
Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. 61
31222845 2020
7
Silencing of the cytokine receptor TNFRSF13B: A new therapeutic target for triple-negative breast cancer. 61
31400636 2020
8
Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E-/- mice. 61
31645012 2020
9
Dysregulated Fcγ receptor IIa-induced cytokine production in dendritic cells of lupus nephritis patients. 61
31509231 2020
10
Extensive serum cytokine analysis in patients with prostate cancer. 61
31430659 2020
11
Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models. 61
31801815 2020
12
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells. 61
31479873 2020
13
The effects of Vitis vinifera L. phenolic compounds on a blood-brain barrier culture model: Expression of leptin receptors and protection against cytokine-induced damage. 61
31562952 2020
14
Toll-like receptor 4 contributes to uterine activation by upregulating pro-inflammatory cytokine and CAP expression via the NF-κB/P38MAPK signaling pathway during pregnancy. 61
31236964 2020
15
Transcription factor and cytokine regulation of eosinophil lineage commitment. 61
31688456 2020
16
Single-Cell Cytokine Analysis to Characterize CAR-T Cell Activation. 61
31776919 2020
17
Piezo1 regulates calcium oscillations and cytokine release from astrocytes. 61
31433095 2020
18
Heterogeneity in the cytokine profile of tuberculosis - diabetes co-morbidity. 61
31472402 2020
19
Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma. 61
31452443 2020
20
Myeloid cell and cytokine interactions with chimeric antigen receptor-T-cell therapy: implication for future therapies. 61
31764168 2020
21
Identification of duplicated suppressor of cytokine signaling 3 (SOCS3) genes in blunt snout bream (Megalobrama amblycephala). 61
31526840 2020
22
miR-22 inhibits synovial fibroblasts proliferation and proinflammatory cytokine production in RASF via targeting SIRT1. 61
31629819 2020
23
Circulating MicroRNAs and T-Cell Cytokine Expression Are Associated With the Characteristics of Asthma Exacerbation. 61
31743969 2020
24
Blood cytokine, chemokine and growth factor profiling in a cohort of pregnant women from tropical countries. 61
31514106 2020
25
Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease. 61
31505020 2020
26
Fast and Accurate Quantitative Analysis of Cytokine Gene Expression in Human Neutrophils by Reverse Transcription Real-Time PCR. 61
31728997 2020
27
Dendritic cell/cytokine-induced killer cell-based immunotherapy in lung cancer: What we know and future landscape. 61
31222740 2020
28
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome. 61
31772015 2019
29
The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin. 61
30945072 2019
30
Serum cytokine and chemokine changes during Toscana virus meningitis. 61
30976912 2019
31
Effective fraction of Bletilla striata reduces the inflammatory cytokine production induced by water and organic extracts of airborne fine particulate matter (PM2.5) in vitro. 61
31842843 2019
32
Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis. 61
31816580 2019
33
Severe Cytokine Release Syndrome after Haploidentical Peripheral Blood Stem Cell Transplantation. 61
31394272 2019
34
Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity. 61
31590920 2019
35
The impact of three commercial sweeteners on cytokine expression by mononuclears impelled by colon carcinoma cells. 61
31066319 2019
36
Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma. 61
31829287 2019
37
Cord blood cytokine profile is associated with the risk of asthma at the age of eight years. 61
31854017 2019
38
BACH2 regulates the function of human CD4+ CD45RA- Foxp3l ° cytokine-secreting T cells and promotes B cell response in Systemic Lupus Erythematosus. 61
31808546 2019
39
Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs. 61
31811089 2019
40
Broncho-vaxom alleviates persistent allergic rhinitis in patients by improving Th1/Th2 cytokine balance of nasal mucosa. 61
31403136 2019
41
Role of astrocytic GABAergic system on inflammatory cytokine-induced anxiety-like behavior. 61
31513788 2019
42
The cytokine IL-17A as a marker of treatment resistance in major depressive disorder? 61
31793127 2019
43
Time Course of Blood and Brain Cytokine/Chemokine Levels Following Adolescent Alcohol Exposure and Withdrawal in Rats. 61
31589333 2019
44
Molecular characterization, expression pattern and evolution of nine suppressors of cytokine signaling (SOCS) gene in the swamp eel (Monopterus albus). 61
31811887 2019
45
Functional conservation and divergence of duplicated the suppressor of cytokine signaling 1 in blunt snout bream (Megalobrama amblycephala). 61
31408625 2019
46
Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages. 61
31827178 2019
47
Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition. 61
31832202 2019
48
Physiologic intestinal 18F-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer. 61
31797893 2019
49
Dendritic Cells Therapy with Cytokine-Induced Killer Cells and Activated Cytotoxic T Cells Attenuated Th2 Bias Immune Response. 61
31793363 2019
50
Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis. 61
31373726 2019
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Variations for Cytokine Deficiency

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Expression for Cytokine Deficiency

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Search GEO for disease gene expression data for Cytokine Deficiency.
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Pathways for Cytokine Deficiency

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Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 63
Show member pathways
 12.87 IL9 IL5 IL13
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.82 IL9 IL5 IL13
3
PAK Pathway 63
Show member pathways
 12.77 IL9 IL5 IL13
4
Allograft rejection 36 1
Show member pathways
 12.35 IL9 IL5 IL13
5
Apoptosis Pathway 70
Show member pathways
 11.99 IL5 IL13
6
IL-17 Family Signaling Pathways 64
Show member pathways
 11.89 IL5 IL13
7
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 11.86 IL9 IL5 IL13
8
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.75 IL9 IL5 IL13
9
MAPK Pathway 70
Show member pathways
 11.6 IL5 IL13
10
Glucocorticoid receptor regulatory network 1
11.41 IL5 IL13
11
Innate Lymphoid Cell Differentiation Pathways 64
11.34 IL9 IL5 IL13
12
Lung fibrosis 1
11.28 IL5 IL13
13
Th2 Differentiation Pathway 64
10.99 IL9 IL5 IL13
14
Cytokines and Inflammatory Response 1
10.87 IL5 IL13
15
Development and heterogeneity of the ILC family 1
10.64 IL9 IL5 IL13
16
G-protein signaling_Rap2B regulation pathway 22
10.54 IL9 IL5 IL13
17
OX40 Pathway 63
10.21 IL9 IL5 IL13
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GO Terms for Cytokine Deficiency

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Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 IL9 IL5 IL13
2 positive regulation of B cell proliferation GO:0030890 8.96 IL5 IL13
3 inflammatory response GO:0006954 8.8 IL9 IL5 IL13

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL9 IL5
2 cytokine receptor binding GO:0005126 8.96 IL9 IL13
3 cytokine activity GO:0005125 8.8 IL9 IL5 IL13
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Sources for Cytokine Deficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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