MCID: CYT002
MIFTS: 39

Cytokine Deficiency

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 54
Cytokine 17

Classifications:



External Ids:

Summaries for Cytokine Deficiency

MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and dermatitis. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include t cells, lung and endothelial, and related phenotype is digestive/alimentary.

Wikipedia : 77 Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell... more...

Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1576)
# Related Disease Score Top Affiliating Genes
1 asthma 31.6 IL13 IL5 IL9
2 dermatitis 30.5 IL13 IL5
3 leishmaniasis 30.1 IL13 IL5
4 pneumonia 30.1 IL13 IL5
5 dermatitis, atopic 30.0 IL13 IL5
6 schistosomiasis 29.9 IL13 IL5
7 rhinitis 29.8 IL13 IL5
8 cutaneous leishmaniasis 29.8 IL13 IL5
9 esophagitis 29.7 IL13 IL5
10 bronchiolitis 29.7 IL13 IL5
11 malaria 29.7 IL13 IL5 IL9
12 allergic rhinitis 29.7 IL13 IL5
13 hypereosinophilic syndrome 29.6 IL13 IL5
14 allergic asthma 29.5 IL13 IL5 IL9
15 food allergy 29.4 IL13 IL5
16 esophagitis, eosinophilic, 1 29.4 IL13 IL5
17 pulmonary eosinophilia 29.4 IL13 IL5
18 sarcoidosis 1 29.4 IL13 IL9
19 lung disease 29.3 IL13 IL5
20 conjunctivitis 29.3 IL13 IL5
21 keratoconjunctivitis 29.3 IL13 IL5
22 tetanus 29.3 IL13 IL5
23 allergic hypersensitivity disease 29.3 IL13 IL5 IL9
24 trichuriasis 29.2 IL13 IL9
25 onchocerciasis 29.2 IL13 IL5
26 vernal keratoconjunctivitis 29.2 IL13 IL5
27 radiculopathy 29.1 IL13 IL5
28 allergic conjunctivitis 29.1 IL13 IL5
29 common cold 29.1 IL13 IL5
30 respiratory allergy 29.1 IL13 IL5
31 ige responsiveness, atopic 29.0 IL13 IL5 IL9
32 angioimmunoblastic lymphadenopathy with dysproteinemia 29.0 IL13 IL5
33 peanut allergy 29.0 IL13 IL9
34 eosinophilic meningitis 28.9 IL13 IL5
35 pollen allergy 28.9 IL13 IL5
36 eosinophilic pneumonia 28.9 IL13 IL5
37 skin disease 28.9 IL13 IL5
38 respiratory syncytial virus infectious disease 28.7 IL13 IL5
39 paragonimiasis 28.7 IL13 IL5
40 angiostrongyliasis 28.7 IL13 IL5
41 latex allergy 28.7 IL13 IL5
42 intestinal schistosomiasis 28.7 IL13 IL5
43 urinary schistosomiasis 28.7 IL13 IL5
44 cytokine receptor deficiency 12.3
45 kshv inflammatory cytokine syndrome 12.2
46 graft-versus-host disease 11.5
47 hemophagocytic lymphohistiocytosis 11.5
48 kaposi sarcoma 11.3
49 mycosis fungoides 11.3
50 multicentric castleman disease 11.3

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency

Symptoms & Phenotypes for Cytokine Deficiency

MGI Mouse Phenotypes related to Cytokine Deficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9

Drugs & Therapeutics for Cytokine Deficiency

Search Clinical Trials , NIH Clinical Center for Cytokine Deficiency

Genetic Tests for Cytokine Deficiency

Anatomical Context for Cytokine Deficiency

MalaCards organs/tissues related to Cytokine Deficiency:

42
T Cells, Lung, Endothelial, Monocytes, Brain, Liver, Breast

Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

(show top 50) (show all 2685)
# Title Authors Year
1
Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. ( 30742679 )
2019
2
Histamine H4 receptor regulates Th2-cytokine profile through thymic stromal lymphopoietin in allergic rhinitis. ( 30848348 )
2019
3
Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis. ( 30767874 )
2019
4
Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis✰. ( 30777365 )
2019
5
Th1/Th17 cytokine profile is induced by macrophage migration inhibitory factor in peripheral blood mononuclear cells from rheumatoid arthritis patients. ( 30698113 )
2019
6
Mouse models of severe asthma for evaluation of therapeutic cytokine targeting. ( 30659868 )
2019
7
Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma. ( 30652675 )
2019
8
Plasma cytokine levels and the presence of colorectal cancer. ( 30883594 )
2019
9
Prognostic value of multiple cytokine analysis in colorectal cancer: a systematic review. ( 30788169 )
2019
10
The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties. ( 30804456 )
2019
11
Predictive value of intratumour inflammatory cytokine mRNA levels of hepatocellular carcinoma patients and activation of two distinct pathways govern IL-8 induced epithelial-mesenchymal transition in human hepatic cancer cell lines. ( 30903867 )
2019
12
Sustained efficacy of adjuvant immunotherapy with cytokine-induced killer cells for hepatocellular carcinoma: an extended 5-year follow-up. ( 30232520 )
2019
13
Defective cytokine production from monocytes/macrophages of E-beta thalassemia patients in response to Pythium insidiosum infection. ( 30765134 )
2019
14
IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury. ( 30641838 )
2019
15
Cytokine Responses in Severe Traumatic Brain Injury: Where There Is Smoke, Is There Fire? ( 29569129 )
2019
16
Alteration of specific cytokine expression patterns in patients with breast cancer. ( 30814616 )
2019
17
Cytokine Modulation in Breast Cancer Patients Undergoing Radiotherapy: A Revision of the Most Recent Studies. ( 30658426 )
2019
18
IL-1β Inflammatory Cytokine-Induced TP63 Isoform ∆NP63α Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. ( 30641908 )
2019
19
Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy. ( 30316668 )
2019
20
B-cell depletion induces a shift in self antigen specific B-cell repertoire and cytokine pattern in patients with bullous pemphigoid. ( 30837635 )
2019
21
Clinical Importance of a Cytokine Network in Major Burns. ( 29621119 )
2019
22
Impaired Th17 cell proliferation and decreased pro-inflammatory cytokine production in CXCR3/CXCR4 double-deficient mice of vulvovaginal candidiasis. ( 30656691 )
2019
23
Generalized Cytokine Increase in the Setting of a Multisystem Clinical Disorder and Carcinoid Syndrome Associated with a Novel NLRP12 Variant. ( 30788684 )
2019
24
Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis. ( 30820752 )
2019
25
Cytometric Bead Array (CBA) for Measuring Cytokine Levels in Chagas Disease Patients. ( 30868537 )
2019
26
Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line. ( 30800160 )
2019
27
Myricetin ameliorates cytokine-induced migration and invasion of cholangiocarcinoma cells via suppression of STAT3 pathway. ( 30880773 )
2019
28
Association of T Helper 1 Cytokine Gene Single Nucleotide Polymorphisms with Ulcerative Colitis and Crohn's Disease. ( 30134230 )
2019
29
Inflammatory Cytokine Profile in Crohn's Disease Nonresponders to Optimal Antitumor Necrosis Factor Therapy. ( 29517712 )
2019
30
Assessment of intralesional cytokine profile of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka. ( 30642262 )
2019
31
Alterations in monocyte subsets and cytokine production after TLR activation in American Cutaneous Leishmaniasis. ( 30870579 )
2019
32
Cytokine-Mediated Induction and Regulation of Tissue Damage During Cytomegalovirus Infection. ( 30761144 )
2019
33
Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: Implications for the cytokine response. ( 30639520 )
2019
34
Cytokine Research in Depression: Principles, Challenges, and Open Questions. ( 30792669 )
2019
35
Cytokine secretion and the risk of depression development in patients with connective tissue diseases. ( 30719813 )
2019
36
Proactive maintenance therapy of canine atopic dermatitis with the anti-IL-31 lokivetmab. Can a monoclonal antibody blocking a single cytokine prevent allergy flares? ( 30672050 )
2019
37
Effects of sitagliptin and vitamin D3 on T helper cell transcription factors and cytokine production in clinical subgroups of type 2 diabetes mellitus: highlights upregulation of FOXP3 and IL-37. ( 30907193 )
2019
38
Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. ( 30588081 )
2019
39
Porcine epidemic diarrhea virus nsp4 induces pro-inflammatory cytokine and chemokine expression inhibiting viral replication in vitro. ( 30799511 )
2019
40
Pro-inflammatory cytokine expression studies of subclinical and clinical endometritis in endometrial tissues of buffaloes. ( 30684222 )
2019
41
The effect of cannabinoid receptor 1 blockade on adipokine and proinflammatory cytokine concentration in adipose and hepatic tissue in mice with nonalcoholic fatty liver disease. ( 30673308 )
2019
42
Interplay Between Helicobacter pylori Infection, Interleukin-11, and Leukemia Inhibitory Factor in Gastric Cancer Among Egyptian Patients, by Sabry D, Abdelaleem OO, Hefzy EM, Ibrahim AA, Ahmed TI, Hassan EA, Abdel-Hameed ND, Khalil MAF. J Interferon Cytokine Res 2018;38(11):517-525. DOI: 10.1089/jir.2018.0065. ( 30794008 )
2019
43
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. ( 30764840 )
2019
44
Tim-3 regulates inflammatory cytokine expression and Th17 cell response induced by monocytes from patients with chronic hepatitis B. ( 30729555 )
2019
45
A new Th-17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26. ( 30829398 )
2019
46
Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis. ( 30784775 )
2019
47
Exclusive Enteral Nutrition: Clinical Effects and Changes in Mucosal Cytokine Profile in Pediatric New Inflammatory Bowel Disease. ( 30781421 )
2019
48
Engineered and wild-type L. lactis promote anti-inflammatory cytokine signalling in inflammatory bowel disease patient's mucosa. ( 30810891 )
2019
49
Corticotropin-releasing factor induces inflammatory cytokines via the NLRP6-inflammatory cytokine axis in a murine model of irritable bowel syndrome. ( 30663229 )
2019
50
Effects of Different Volatile Anesthetics on Cytokine and Chemokine Production After Ischemia-Reperfusion Injury in Patients Undergoing Living-Donor Kidney Transplant. ( 30777526 )
2019

Variations for Cytokine Deficiency

Expression for Cytokine Deficiency

Search GEO for disease gene expression data for Cytokine Deficiency.

Pathways for Cytokine Deficiency

Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 IL13 IL5 IL9
2
Show member pathways
12.89 IL13 IL5 IL9
3
Show member pathways
12.84 IL13 IL5 IL9
4
Show member pathways
12.79 IL13 IL5 IL9
5
Show member pathways
12.41 IL13 IL5 IL9
6
Show member pathways
12.01 IL13 IL5
7
Show member pathways
11.99 IL5 IL9
8
Show member pathways
11.91 IL13 IL5
9
Show member pathways
11.91 IL13 IL5 IL9
10
Show member pathways
11.79 IL13 IL5 IL9
11
Show member pathways
11.63 IL13 IL5
12
Show member pathways
11.62 IL13 IL5 IL9
13 11.44 IL13 IL5
14 11.34 IL13 IL5 IL9
15 11.31 IL13 IL5
16 10.99 IL13 IL5 IL9
17 10.92 IL13 IL5
18 10.73 IL13 IL5 IL9
19 10.64 IL13 IL5 IL9
20 10.56 IL13 IL5 IL9
21 10.21 IL13 IL5 IL9

GO Terms for Cytokine Deficiency

Cellular components related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 IL13 IL5 IL9

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 IL13 IL5 IL9
2 cytokine-mediated signaling pathway GO:0019221 9.32 IL13 IL5
3 positive regulation of B cell proliferation GO:0030890 9.16 IL13 IL5
4 regulation of signaling receptor activity GO:0010469 9.13 IL13 IL5 IL9
5 inflammatory response GO:0006954 8.8 IL13 IL5 IL9

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL5 IL9
2 cytokine receptor binding GO:0005126 8.96 IL13 IL9
3 cytokine activity GO:0005125 8.8 IL13 IL5 IL9

Sources for Cytokine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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