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MCID: CYT002
MIFTS: 44

Cytokine Deficiency

Categories: Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cytokine Deficiency

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MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 52
Cytokine 17

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


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Summaries for Cytokine Deficiency

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MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and proteasome-associated autoinflammatory syndrome 1. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Fluticasone and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and monocytes, and related phenotype is digestive/alimentary.

Wikipedia : 74 Cytokines are a broad and loose category of small proteins (~5-20 kDa) that are important in cell... more...

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Related Diseases for Cytokine Deficiency

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Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2473)
# Related Disease Score Top Affiliating Genes
1 asthma 31.4 IL9 IL5 IL13
2 proteasome-associated autoinflammatory syndrome 1 30.5 IL5 IL13
3 dermatitis 30.4 IL5 IL13
4 leishmaniasis 30.2 IL5 IL13
5 autoimmune disease 30.2 IL9 IL5 IL13
6 ige responsiveness, atopic 30.1 IL5 IL13
7 sarcoidosis 1 30.1 IL9 IL13
8 lymphoma, hodgkin, classic 30.1 IL9 IL13
9 mastocytosis 30.0 IL9 IL13
10 severe combined immunodeficiency, x-linked 29.9 IL9 IL13
11 dermatitis, atopic 29.9 IL9 IL5 IL13
12 allergic contact dermatitis 29.9 IL9 IL5
13 cutaneous leishmaniasis 29.9 IL5 IL13
14 bronchiolitis 29.9 IL5 IL13
15 hypereosinophilic syndrome 29.9 IL9 IL5 IL13
16 rhinitis 29.8 IL9 IL5 IL13
17 severe combined immunodeficiency 29.8 IL9 IL5 IL13
18 conjunctivitis 29.8 IL5 IL13
19 allergic rhinitis 29.8 IL9 IL5 IL13
20 allergic asthma 29.8 IL9 IL5 IL13
21 allergic hypersensitivity disease 29.8 IL9 IL5 IL13
22 lung disease 29.8 IL9 IL5 IL13
23 chronic fatigue syndrome 29.8 IL5 IL13
24 inflammatory bowel disease 29.7 IL9 IL5 IL13
25 esophagitis 29.7 IL5 IL13
26 keratoconjunctivitis 29.7 IL5 IL13
27 food allergy 29.7 IL5 IL13
28 multiple sclerosis 29.7 IL9 IL5 IL13
29 eosinophilic pneumonia 29.6 IL5 IL13
30 tetanus 29.6 IL9 IL5 IL13
31 filarial elephantiasis 29.6 IL5 IL13
32 pulmonary disease, chronic obstructive 29.6 IL9 IL5 IL13
33 urticaria 29.6 IL5 IL13
34 pulmonary eosinophilia 29.5 IL5 IL13
35 pollen allergy 29.5 IL5 IL13
36 allergic conjunctivitis 29.5 IL5 IL13
37 trichuriasis 29.5 IL9 IL13
38 vernal keratoconjunctivitis 29.5 IL5 IL13
39 diphtheria 29.5 IL5 IL13
40 bullous pemphigoid 29.5 IL5 IL13
41 common cold 29.5 IL5 IL13
42 castleman disease 29.4 IL9 IL5
43 interstitial lung disease 29.4 IL5 IL13
44 pulmonary fibrosis, idiopathic 29.4 IL9 IL5 IL13
45 esophagitis, eosinophilic, 1 29.4 IL5 IL13
46 stevens-johnson syndrome/toxic epidermal necrolysis 29.4 IL5 IL13
47 malaria 29.4 IL9 IL5 IL13
48 bronchitis 29.3 IL9 IL5 IL13
49 onchocerciasis 29.3 IL5 IL13
50 ascaris lumbricoides infection 29.2 IL5 IL13

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency
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Symptoms & Phenotypes for Cytokine Deficiency

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MGI Mouse Phenotypes related to Cytokine Deficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9
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Drugs & Therapeutics for Cytokine Deficiency

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Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 980)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
2
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
3
Desogestrel Approved Phase 4 54024-22-5 40973
4
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
5
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
6
Basiliximab Approved, Investigational Phase 4 179045-86-4, 152923-56-3
7
Dinoprostone Approved Phase 4 363-24-6 5280360
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11
Methyltestosterone Approved Phase 4 58-18-4 6010
12
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
13
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
14
Testosterone enanthate Approved Phase 4 315-37-7 9416
15
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
16
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
17
Omalizumab Approved, Investigational Phase 4 242138-07-4
18
Oxacillin Approved, Investigational Phase 4 66-79-5 6196
19
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
20
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
21
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
22
Etanercept Approved, Investigational Phase 4 185243-69-0
23
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
24
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
25
Metformin Approved Phase 4 657-24-9 14219 4091
26
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
27
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
28
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
29
Calcium carbonate Approved, Investigational Phase 4 471-34-1
30
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
31 silver nitrate Approved, Investigational Phase 4
32
Silver sulfadiazine Approved, Vet_approved Phase 4 22199-08-2 441244
33
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
34
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
35
Peginterferon alfa-2b Approved Phase 4 215647-85-1, 99210-65-8
36
Nifedipine Approved Phase 4 21829-25-4 4485
37
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
38
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 6447131 17753757
39
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
40
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 6474909
41
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
42
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
43
Haloperidol Approved Phase 4 52-86-8 3559
44
Clonidine Approved Phase 4 4205-90-7 2803
45
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
46
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
47
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
48
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
49
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
50
Midodrine Approved Phase 4 42794-76-3, 133163-28-7 4195

Interventional clinical trials:

(show top 50) (show all 3009)
# Name Status NCT ID Phase Drugs
1 Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations Unknown status NCT01213667 Phase 4 Ranibizumab
2 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
3 Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR Unknown status NCT00289679 Phase 4
4 Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Were Treated With H.P. Acthar Gel After an Incomplete Response to Combinations of DMARDs and Biologic DMRADs Unknown status NCT03082573 Phase 4 H.P. Acthar gel
5 Mechanisms of Endotoxin-Tolerance of Human Monocytes After CABG-Sugery - Effects of Hemofiltration and Mannitol Treatment Unknown status NCT00426192 Phase 4 i.v. mannitol
6 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
7 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
8 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
9 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
10 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
11 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
12 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
13 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
14 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
15 Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
16 Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients Unknown status NCT01417273 Phase 4 Drug: placebo
17 The Safety and Efficacy of Etanercept in Treating Patient With Acute ST Segment Elevated Myocardial Infarction Unknown status NCT01372930 Phase 4 Etanercept;saline
18 Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis Unknown status NCT02796794 Phase 4
19 Asthma and Vitamin D (a Clinical Pilot Study) Unknown status NCT00712205 Phase 4 Placebo;Calcitriol
20 Short Term Diet Intervention in Newly Diagnosed Type 2 Diabetes. a Randomised, Multicentric, Controlled, Clinical Trial Unknown status NCT01409330 Phase 4
21 Phase 4 Study of the Efficacy of Intralipid Treatment in Patients With Recurrent Implantation Failure and Miscarriages With High Peripheral and Uterine Natural Killer Cells Unknown status NCT01679561 Phase 4 intralipid
22 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
23 Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness in Type 2 Diabetes Patient With Metabolic Syndrome (Randomized, Double-Blind, Placebo-Controled, Cross-Over Study) Unknown status NCT00573950 Phase 4 cilostazol;Placebo
24 Immunological Mechanisms of Oralair® (5 Grass Mix Sublingual Allergen Immunotherapy Tablet) in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
25 The Effects of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring (NuvaRing®) on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
26 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
27 Rifaximin Predicts the Complications of Decompensated Cirrhosis: a Randomized Controlled Trial Unknown status NCT02074280 Phase 4 rifaximin
28 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission: a Prospective, Pilot Study. Unknown status NCT03244709 Phase 4 Tocilizumab
29 Rifaximin Reduces the Complications of Decompensated Cirrhosis Unknown status NCT02190357 Phase 4 Rifaximin
30 Comparison the Efficacy and Safety of 0.1% Tacrolimus Ointment With 0.1% Mometasone Furoate Cream in the Treatment of Adult Vitiligo: A Single Blinded Pilot Study Unknown status NCT01333410 Phase 4 tacrolimus ointment;Mometasone furoate
31 Effects of the Use of "de Novo" Everolimus for the Expression of Cytokines in Kidneys From Extended Criteria Donors and With Delayed Graft Function Unknown status NCT01663805 Phase 4 Everolimus
32 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
33 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
34 Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma Unknown status NCT00307606 Phase 4 Solu-medrol 125 mg
35 Granulocyte Colony Stimulating Factor Plus N-Acetyl Cysteine In Severe Alcoholic Hepatitis Unknown status NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
36 Phase 4 Study: Comparison of Myfortic and Early Rapamycin Conversion vs. Low-Dose Tacrolimus in Preventing Acute Rejection and Chronic Allograft Fibrosis: A Protocol Biopsy Directed Approach Unknown status NCT00896012 Phase 4 Rapamune (sirolimus/rapamycin);Tacrolimus
37 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
38 A Clinical Study of Biomarkers of Innate and Adaptive Immune Activation Associated With Symptoms and Immune Responses After Administration of a Single Dose of a Quadrivalent Inactivated Split Virus Influenza Vaccine to Healthy Young Adults. Unknown status NCT03160118 Phase 4 Seasonal,quadrivalent,influenza vaccine
39 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau Unknown status NCT00168610 Phase 4 Vitamin A
40 Phase 4 Clinical Trial to Examine the Role of Rosuvastatin and Exercise Treatment in Modulating Inflammatory Response in Hypercholesterolemic Subjects Unknown status NCT00295373 Phase 4 Rosuvastatin
41 Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau Unknown status NCT02953327 Phase 4
42 The Influence of BCG Vaccine as a Booster TDaP-IPV Vaccination: an Explorative Study Unknown status NCT02771782 Phase 4
43 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Unknown status NCT02644707 Phase 4
44 A Pilot Study to Evaluate the Efficacy and Safety of Pegylated Interferon Alfa-2b Plus Ribavirin in the Treatment of Patients With Dual Chronic Hepatitis B and Delta Unknown status NCT00117533 Phase 4 pegylated IFN alfa-2b plus ribavirin
45 The Impact of Conventional Hemodialysis, High Flux Hemodialysis and Hemodiafiltration on Adiponectin, Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
46 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
47 Advair - CRP Study Unknown status NCT00120978 Phase 4 Advair;Flovent
48 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
49 Safety and Efficacy of Immunosuppression With Basiliximab, Delayed Dose Tacrolimus Plus Enteric Coated Mycophenolic Acid, Versus Standard Dose Tacrolimus, Enteric Coated Mycophenolic Acid Plus Corticosteroids in Patients Undergoing Orthotopic Liver Transplantation (OLT) Unknown status NCT02123108 Phase 4 Basiliximab
50 Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) Unknown status NCT02798068 Phase 4 Solu-medrol or placebo administration

Search NIH Clinical Center for Cytokine Deficiency

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Genetic Tests for Cytokine Deficiency

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Anatomical Context for Cytokine Deficiency

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MalaCards organs/tissues related to Cytokine Deficiency:

40
T Cells, Lung, Monocytes, Liver, Breast, Bone, Endothelial
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Publications for Cytokine Deficiency

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Articles related to Cytokine Deficiency:

(show top 50) (show all 30019)
# Title Authors PMID Year
1
Suppressors of cytokine signaling proteins as modulators of development and innate immunity of insects. 61
31785267 2020
2
Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis. 61
31816580 2020
3
Cytokine receptor splice variants in hematologic diseases. 61
31816579 2020
4
Multiple cytokine analyses of aqueous humor from the patients with retinitis pigmentosa. 61
31810025 2020
5
Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. 61
31838149 2020
6
Melamine and curcumin enriched diets modulate the haemato-immune response, growth performance, oxidative stress, disease resistance, and cytokine production in oreochromis niloticus. 61
31945653 2020
7
The effect of infliximab and octreotide on cytokine levels experimental proliferative vitreoretinopathy. 61
31809602 2020
8
Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair. 61
31837586 2020
9
Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings. 61
31805478 2020
10
Protein microarray analysis of cytokine expression changes in distal stumps after sciatic nerve transection. 61
31571662 2020
11
Capacitance electrochemical biosensor based on silicon nitride transducer for TNF-α cytokine detection in artificial human saliva: Heart failure (HF). 61
31892087 2020
12
Modulation of cytokine patterns and microbiome during pregnancy in IBD. 61
31167813 2020
13
Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome. 61
31914175 2020
14
Complete Surgical Metastasectomy of Renal Cell Carcinoma in the Post-Cytokine Era. 61
31393812 2020
15
A self-assembled peptide hydrogel for cytokine sequestration. 61
31919489 2020
16
The cytokine profile of follicular fluid changes during ovarian ageing. 61
32028036 2020
17
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. 61
32029621 2020
18
The elevated systemic cytokine levels in HIV patients are not associated with an elevated pulmonary cytokine environment. 61
31655458 2020
19
IL-33 promotes type 1 cytokine expression via p38 MAPK in human NK cells. 61
32017227 2020
20
Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. 61
31427752 2020
21
Clinical correlation of liver function tests with suppression of cytokine signaling (SOCS1) gene expression in HCV infected patients: A real-world clinical experience. 61
31535716 2020
22
Impact of different antimycotics on cytokine levels in an in vitro aspergillosis model in human whole blood. 61
31372914 2020
23
Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6. 61
31678540 2020
24
Multiple cytokine-producing aggressive EBV-positive diffuse large B cell lymphoma, not otherwise specified with hemophagocytic syndrome. 61
31768673 2020
25
Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial. 61
31707049 2020
26
An Injectable Cytokine Trap for Local Treatment of Autoimmune Disease. 61
31753473 2020
27
Effects of interferon and glatiramer acetate on cytokine patterns in multiple sclerosis patients. 61
31731047 2020
28
Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. 61
32033836 2020
29
LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer. 61
31910343 2020
30
Cytokine secretion in breast cancer cells - MILLIPLEX assay data. 61
31828190 2020
31
Macrophages Instruct Aberrant Glycosylation in Colon Cancer by Chemokine and Cytokine Signals. 61
32015012 2020
32
Time-series clustering of cytokine expression after transarterial chemoembolization in patients with hepatocellular carcinoma. 61
31966047 2020
33
Corrigendum: OMIP-056: Evaluation of Human Conventional T Cells, Donor-Unrestricted T Cells, and NK Cells Including Memory Phenotype by Intracellular Cytokine Staining. 61
31989802 2020
34
Effect of pregnancy hormone mixtures on cytokine production and surface marker expression in naïve and LPS-activated THP-1 differentiated monocytes/macrophages. 61
31364430 2020
35
Dynamics of pro- and anti-inflammatory cytokine changes in serum and assessment of their diagnostic utility during lactation impairment in pigs. 61
31706218 2020
36
Effects of carbohydrate and glutamine supplementation on cytokine production by monocytes after exercise in hypoxia: A crossover, randomized, double-blind pilot study. 61
31743809 2020
37
Corrigendum to "Inflammatory biomarkers in patients in simvastatin treatment: No effect of co-enzyme Q10 supplementation" [Cytokine 113 (2019) 393-399]. 61
31818692 2020
38
Influence of fish protein hydrolysate produced from industrial residues on antioxidant activity, cytokine expression and gut microbial communities in juvenile barramundi Lates calcarifer. 61
31866445 2020
39
MPMBP down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB but not AP-1 activation. 61
31901621 2020
40
Suppressor of cytokine signalling 3 is crucial for interleukin-7 receptor re-expression after T-cell activation and interleukin-7 dependent proliferation. 61
31621896 2020
41
Role of heat shock protein and cytokine expression as markers of clinical outcomes with glutamine-supplemented parenteral nutrition in surgical ICU patients. 61
30981628 2020
42
Preconditioning rats with three lipid emulsions prior to acute lung injury affects cytokine production and cell apoptosis in the lung and liver. 61
32024527 2020
43
Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism. 61
32025852 2020
44
Cytokine and chemokine regulation of venous thromboembolism. 61
32020753 2020
45
Cytokine responses to symbiotic and lactoferrin combination in very low birth weight neonates: a randomized control trial. 61
31984696 2020
46
Fetal cytokine response to porcine reproductive and respiratory syndrome virus-2 infection. 61
31629108 2020
47
Photobiomodulation of inflammatory-cytokine-related effects in a 3-D culture model with gingival fibroblasts. 61
32030556 2020
48
The evolution and function characterization of suppressor of cytokine signaling 1b (SOCS1b) in miiuy croaker. 61
31846779 2020
49
The potential role of B5: A stitch in time and switch in cytokine. 61
31691401 2020
50
Bronchoalveolar lavage fluid cytokine, cytology and IgE allergen in horses with equine asthma. 61
31786444 2020
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Variations for Cytokine Deficiency

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Expression for Cytokine Deficiency

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Search GEO for disease gene expression data for Cytokine Deficiency.
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Pathways for Cytokine Deficiency

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Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 63
Show member pathways
 12.87 IL9 IL5 IL13
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.82 IL9 IL5 IL13
3
PAK Pathway 63
Show member pathways
 12.77 IL9 IL5 IL13
4
Allograft rejection 1 36
Show member pathways
 12.35 IL9 IL5 IL13
5
Apoptosis Pathway 70
Show member pathways
 11.99 IL5 IL13
6
IL-17 Family Signaling Pathways 64
Show member pathways
 11.89 IL5 IL13
7
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 11.86 IL9 IL5 IL13
8
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.75 IL9 IL5 IL13
9
MAPK Pathway 70
Show member pathways
 11.6 IL5 IL13
10
Glucocorticoid receptor regulatory network 1
11.41 IL5 IL13
11
Innate Lymphoid Cell Differentiation Pathways 64
11.34 IL9 IL5 IL13
12
Lung fibrosis 1
11.28 IL5 IL13
13
Th2 Differentiation Pathway 64
10.99 IL9 IL5 IL13
14
Cytokines and Inflammatory Response 1
10.87 IL5 IL13
15
Development and heterogeneity of the ILC family 1
10.64 IL9 IL5 IL13
16
G-protein signaling_Rap2B regulation pathway 22
10.54 IL9 IL5 IL13
17
OX40 Pathway 63
10.21 IL9 IL5 IL13
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GO Terms for Cytokine Deficiency

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Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 IL9 IL5 IL13
2 positive regulation of B cell proliferation GO:0030890 8.96 IL5 IL13
3 inflammatory response GO:0006954 8.8 IL9 IL5 IL13

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL9 IL5
2 cytokine receptor binding GO:0005126 8.96 IL9 IL13
3 cytokine activity GO:0005125 8.8 IL9 IL5 IL13
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Sources for Cytokine Deficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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