MCID: CYT002
MIFTS: 26

Cytokine Deficiency

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 53

Classifications:



Summaries for Cytokine Deficiency

MalaCards based summary : Cytokine Deficiency is related to angioimmunoblastic lymphadenopathy with dysproteinemia and dermatitis. An important gene associated with Cytokine Deficiency is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include endothelial, t cells and lung, and related phenotype is digestive/alimentary.

Wikipedia : 76 Cytokines are a broad and loose category of small proteins (~5�??20 kDa) that are important in cell... more...

Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 IL13 IL5
2 dermatitis 10.0 IL13 IL5
3 respiratory syncytial virus infectious disease 10.0 IL13 IL5
4 nickel allergic contact dermatitis 10.0 IL13 IL5
5 paragonimiasis 10.0 IL13 IL5
6 angiostrongyliasis 10.0 IL13 IL5
7 inflammatory bowel disease 4 10.0 IL13 IL5
8 apple allergy 10.0 IL13 IL5
9 strongyloidiasis 10.0 IL13 IL5
10 ascaris lumbricoides infection 10.0 IL13 IL5
11 latex allergy 10.0 IL13 IL5
12 eosinophilic meningitis 10.0 IL13 IL5
13 intestinal schistosomiasis 10.0 IL13 IL5
14 schistosomiasis 10.0 IL13 IL5
15 chronic tic disorder 10.0 IL13 IL5
16 chronic conjunctivitis 10.0 IL13 IL5
17 conjunctivitis 10.0 IL13 IL5
18 eosinophilic gastritis 10.0 IL13 IL5
19 vernal keratoconjunctivitis 10.0 IL13 IL5
20 keratoconjunctivitis 10.0 IL13 IL5
21 urinary schistosomiasis 10.0 IL13 IL5
22 esophagitis 10.0 IL13 IL5
23 esophagitis, eosinophilic, 1 10.0 IL13 IL5
24 pollen allergy 10.0 IL13 IL5
25 conjunctival disease 10.0 IL13 IL5
26 night blindness, congenital stationary, type 1a 10.0 IL13 IL5
27 pulmonary eosinophilia 10.0 IL13 IL5
28 stevens-johnson syndrome/toxic epidermal necrolysis 10.0 IL13 IL5
29 paranasal sinus disease 10.0 IL13 IL5
30 eosinophilic pneumonia 10.0 IL13 IL5
31 pneumonia 10.0 IL13 IL5
32 onchocerciasis 10.0 IL13 IL5
33 allergic conjunctivitis 10.0 IL13 IL5
34 nasal cavity disease 10.0 IL13 IL5
35 nose disease 10.0 IL13 IL5
36 common cold 10.0 IL13 IL5
37 respiratory allergy 10.0 IL13 IL5
38 parasitic helminthiasis infectious disease 10.0 IL13 IL5
39 food allergy 10.0 IL13 IL5
40 upper respiratory tract disease 10.0 IL13 IL5
41 cutaneous leishmaniasis 10.0 IL13 IL5
42 leishmaniasis 10.0 IL13 IL5
43 bronchial disease 10.0 IL13 IL5
44 trichuriasis 10.0 IL13 IL9
45 bronchiolitis 10.0 IL13 IL5
46 immune system disease 10.0 IL13 IL5
47 proteasome-associated autoinflammatory syndrome 1 9.9 IL13 IL5
48 tetanus 9.9 IL13 IL5
49 hypereosinophilic syndrome 9.9 IL13 IL5
50 trichinosis 9.9 IL5 IL9

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency

Symptoms & Phenotypes for Cytokine Deficiency

MGI Mouse Phenotypes related to Cytokine Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9

Drugs & Therapeutics for Cytokine Deficiency

Search Clinical Trials , NIH Clinical Center for Cytokine Deficiency

Genetic Tests for Cytokine Deficiency

Anatomical Context for Cytokine Deficiency

MalaCards organs/tissues related to Cytokine Deficiency:

41
Endothelial, T Cells, Lung, Skin

Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

# Title Authors Year
1
Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis. ( 25888308 )
2015
2
Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. ( 21482794 )
2011
3
A shift towards a T cell cytokine deficiency along with an anti-inflammatory/regulatory microenvironment may enable the synthesis of anti-FVIII inhibitors in haemophilia A patients. ( 20846164 )
2010
4
Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. ( 18410989 )
2008
5
Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE. ( 11891780 )
2002
6
Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice. ( 9199446 )
1997

Variations for Cytokine Deficiency

Expression for Cytokine Deficiency

Search GEO for disease gene expression data for Cytokine Deficiency.

Pathways for Cytokine Deficiency

Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 IL13 IL5 IL9
2
Show member pathways
12.89 IL13 IL5 IL9
3
Show member pathways
12.84 IL13 IL5 IL9
4
Show member pathways
12.79 IL13 IL5 IL9
5
Show member pathways
12.41 IL13 IL5 IL9
6
Show member pathways
12.01 IL13 IL5
7
Show member pathways
11.99 IL5 IL9
8
Show member pathways
11.91 IL13 IL5
9
Show member pathways
11.91 IL13 IL5 IL9
10
Show member pathways
11.79 IL13 IL5 IL9
11
Show member pathways
11.63 IL13 IL5
12
Show member pathways
11.62 IL13 IL5 IL9
13 11.44 IL13 IL5
14 11.34 IL13 IL5 IL9
15 11.31 IL13 IL5
16 10.99 IL13 IL5 IL9
17 10.92 IL13 IL5
18 10.73 IL13 IL5 IL9
19 10.64 IL13 IL5 IL9
20 10.56 IL13 IL5 IL9
21 10.21 IL13 IL5 IL9

GO Terms for Cytokine Deficiency

Cellular components related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 IL13 IL5 IL9

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 IL13 IL5 IL9
2 cytokine-mediated signaling pathway GO:0019221 9.32 IL13 IL5
3 positive regulation of B cell proliferation GO:0030890 9.16 IL13 IL5
4 regulation of signaling receptor activity GO:0010469 9.13 IL13 IL5 IL9
5 inflammatory response GO:0006954 8.8 IL13 IL5 IL9

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL5 IL9
2 cytokine receptor binding GO:0005126 8.96 IL13 IL9
3 cytokine activity GO:0005125 8.8 IL13 IL5 IL9

Sources for Cytokine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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