MCID: CYT002
MIFTS: 43

Cytokine Deficiency

Categories: Rare diseases

Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 20
Cytokine 17

Classifications:



External Ids:

Summaries for Cytokine Deficiency

MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and severe combined immunodeficiency. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and monocytes, and related phenotype is digestive/alimentary.

Wikipedia : 74 Cytokines are a broad and loose category of small proteins (~5-20 kDa) important in cell signaling.... more...

Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2140)
# Related Disease Score Top Affiliating Genes
1 asthma 30.9 IL9 IL5 IL13
2 severe combined immunodeficiency 30.8 IL9 IL13
3 proteasome-associated autoinflammatory syndrome 1 30.8 IL5 IL13
4 dermatitis 30.7 IL5 IL13
5 leishmaniasis 30.5 IL5 IL13
6 pneumonia 30.4 IL5 IL13
7 ige responsiveness, atopic 30.4 IL5 IL13
8 contact dermatitis 30.4 IL9 IL5
9 autoimmune disease 30.3 IL9 IL5 IL13
10 dermatitis, atopic 30.3 IL9 IL5 IL13
11 sarcoidosis 1 30.3 IL9 IL13
12 meningitis 30.3 IL5 IL13
13 leprosy 3 30.3 IL5 IL13
14 hypereosinophilic syndrome 30.3 IL9 IL5 IL13
15 lymphoma, hodgkin, classic 30.3 IL9 IL13
16 allergic contact dermatitis 30.2 IL9 IL5
17 allergic disease 30.2 IL9 IL5 IL13
18 cutaneous leishmaniasis 30.2 IL5 IL13
19 allergic asthma 30.2 IL9 IL5 IL13
20 rhinitis 30.2 IL9 IL5 IL13
21 allergic rhinitis 30.2 IL9 IL5 IL13
22 mastocytosis 30.1 IL9 IL13
23 severe combined immunodeficiency, x-linked 30.1 IL9 IL13
24 tetanus 30.1 IL9 IL5 IL13
25 chronic fatigue syndrome 30.0 IL5 IL13
26 esophagitis 30.0 IL5 IL13
27 conjunctivitis 30.0 IL5 IL13
28 lung disease 30.0 IL9 IL5 IL13
29 inflammatory bowel disease 30.0 IL9 IL5 IL13
30 multiple sclerosis 30.0 IL9 IL5 IL13
31 schistosomiasis 30.0 IL9 IL5 IL13
32 pemphigoid 30.0 IL5 IL13
33 food allergy 29.9 IL5 IL13
34 keratoconjunctivitis 29.9 IL5 IL13
35 bronchiolitis 29.9 IL9 IL5 IL13
36 pulmonary disease, chronic obstructive 29.9 IL9 IL5 IL13
37 eosinophilic pneumonia 29.9 IL5 IL13
38 malaria 29.8 IL9 IL5 IL13
39 diphtheria 29.8 IL5 IL13
40 urticaria 29.8 IL5 IL13
41 pollen allergy 29.8 IL5 IL13
42 common cold 29.8 IL5 IL13
43 trichuriasis 29.8 IL9 IL13
44 pulmonary eosinophilia 29.8 IL5 IL13
45 bullous pemphigoid 29.7 IL5 IL13
46 respiratory allergy 29.7 IL5 IL13
47 chronic asthma 29.7 IL5 IL13
48 pulmonary fibrosis, idiopathic 29.7 IL9 IL5 IL13
49 allergic conjunctivitis 29.7 IL5 IL13
50 combined immunodeficiency 29.7 IL9 IL5 IL13

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency

Symptoms & Phenotypes for Cytokine Deficiency

MGI Mouse Phenotypes related to Cytokine Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9

Drugs & Therapeutics for Cytokine Deficiency

Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 554)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved, Experimental Phase 4 331731-18-1 16219006
2
Infliximab Approved Phase 4 170277-31-3
3
Atenolol Approved Phase 4 29122-68-7 2249
4
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
6
Etanercept Approved, Investigational Phase 4 185243-69-0
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Iron Approved Phase 4 7439-89-6 23925 29936
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
11
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
12
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
14
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
15
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
16
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
17
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
18
Mycophenolic acid Approved Phase 4 24280-93-1 446541
19
Fluorouracil Approved Phase 4 51-21-8 3385
20
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
21
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
22
Citalopram Approved Phase 4 59729-33-8 2771
23
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
24
Ibuprofen Approved Phase 4 15687-27-1 3672
25
Tocopherol Approved, Investigational Phase 4 1406-66-2
26
leucovorin Approved Phase 4 58-05-9 6006
27
Copper Approved, Investigational Phase 4 7440-50-8 27099
28
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
29
Azithromycin Approved Phase 4 83905-01-5 55185 447043
30
Omalizumab Approved, Investigational Phase 4 242138-07-4
31
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
32
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
33
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
34
Nifedipine Approved Phase 4 21829-25-4 4485
35
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
36
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
37
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
38
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
39
Glimepiride Approved Phase 4 93479-97-1 3476
40
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
41
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
42
Losartan Approved Phase 4 114798-26-4 3961
43
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
44
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
45
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
46
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
47
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
48
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
49
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
50
Ranibizumab Approved Phase 4 347396-82-1 459903

Interventional clinical trials:

(show top 50) (show all 961)
# Name Status NCT ID Phase Drugs
1 The Effects of Intravitral Ozurdex Implant in DME: Cytokine Change in Aqueous Humor Unknown status NCT03475407 Phase 4 Ozurdex intravitreal injection
2 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
3 Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations Unknown status NCT01213667 Phase 4 Ranibizumab
4 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
5 Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR Unknown status NCT00289679 Phase 4
6 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
7 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
8 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
9 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
10 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
11 Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis Unknown status NCT02796794 Phase 4
12 Different Day Regimes of Preoperative CONbercept Administration on CytokinEs of Proliferative Diabetic Retinopathy Patients Undergoing Vitrectomy: a Prospective Randomized Controlled Clinical Trial (CONCEPT) Unknown status NCT03506750 Phase 4 IVC
13 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
14 Prevention of Pro-inflammatory Cytokines-associated Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block Unknown status NCT02144766 Phase 4 ropivacaine;saline
15 The Effect of Perioperative Atenolol on Post-Operative Cytokines Unknown status NCT00202358 Phase 4 atenolol;placebo
16 Effects of the Use of "de Novo" Everolimus for the Expression of Cytokines in Kidneys From Extended Criteria Donors and With Delayed Graft Function Unknown status NCT01663805 Phase 4 Everolimus
17 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
18 Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
19 Impact of Probiotics on the Intestinal Microbiota and Its Association With Postoperative Outcome After Colorectal Surgery Completed NCT01609660 Phase 4
20 A Phase 4 Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis Completed NCT03331835 Phase 4 Fumaric acid esters
21 The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression Completed NCT00254020 Phase 4 Citalopram
22 EFFECTS OF NSAIDs ON CLINICAL OUTCOMES, SYNOVIAL FLUID CYTOKINE CONCENTRATION AND SIGNAL TRANSDUCTION PATHWAYS IN KNEE OSTEOARTHRITIS Completed NCT01860833 Phase 4 Ibuprofen;Celecoxib;Diclofenac
23 TNF-α Blockade for Psoriatic Arthritis - A Clinical and MRI Study, and the Effects on Cytokine and Cardiovascular Risk Profile Completed NCT00432406 Phase 4 Infliximab;Etanercept
24 Effect of Preemptive Epidural Analgesia in Labor on Pro and Anti-inflammatory Cytokine Production in a Mother and a Newborn Completed NCT00361712 Phase 4 Standard of care
25 Phenotype and Cytokine Production Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Aldara 5% Cream Using Flow Cytometry Completed NCT00176943 Phase 4 Aldara Cream 5%
26 The Effect of Preoperative Topical Ketorolac 0.45% on Aqueous Cytokine Levels and Macular Thickness in Diabetic and Non Diabetic Patients Undergoing Cataract Surgery Completed NCT02646072 Phase 4 Ketorolac tromethamine ophthalmic solution 0.45%
27 Anti Cytokine Combination Therapy With Daclizumab and Infliximab for Treatment of Steroid Refractory Acute GVHD Completed NCT00574470 Phase 4 daclizumab, infliximab
28 Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans. Completed NCT00431691 Phase 4 vitamin and mineral supplement;Escherichia coli Endotoxin (LPS);100% O2;nitroglycerin
29 The Effect of Xolair (Omalizumab) on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Completed NCT00657891 Phase 4 Omalizumab;Placebo
30 A Multi-Center, Open-Label Study Evaluating the Cytokine and Eyelid Margin Bacterial Load Levels of Subjects Diagnosed With Chronic Blepharitis Following Dosing With AzaSite® (Azithromycin Ophthalmic Solution) 1% Completed NCT00629941 Phase 4 AzaSite®
31 TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience Completed NCT04730323 Phase 4 Tocilizumab
32 The Effect of Zinc, Beta-carotene, and Vitamin D3 Supplementation as Pro-inflammation Mediated Regulator in Preterm Delivery Through Placental Protein Adaptor MyD88 and TRIF, Transcription Factor NFkB, and Pro-inflammatory Cytokine IL-1β Completed NCT03005496 Phase 4 Zinc;Nifedipine;Beta Carotene;Vitamin D3;Dexamethasone
33 Effects of Fingolimod (Gilenya®) on Cytokine and Chemokine Levels in Relapsing Remitting Multiple Sclerosis Patients Completed NCT02373098 Phase 4 Fingolimod 0.5 mg
34 Recurrent Urinary Tract Infections in Children: Bacterial Identification, Antibiotic Susceptibility Profiling and Cytokine Levels Associated With Antibiotic Prophylaxis Completed NCT02357758 Phase 4 Antibiotic Prophylaxis
35 Clinical Efficacy of Chemotherapy Combined With Cytokine-induced Killer in Treatment of Patients With Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
36 Preoperative Versus Postoperative Ultrasound-guided Rectus Sheath Block for Improving Pain, Sleep Quality and Cytokine Levels of Patients With Open Midline Incisions Undergoing Transabdominal Gynaecological Operation Completed NCT02477098 Phase 4 preoperative 0.5% ropivacaine hydrochloride preoperative;postoperative 0.5% Ropivacaine hydrochloride
37 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Treatment Naïve Patients With Diabetic Macular Edema Completed NCT02441907 Phase 4 aflibercept
38 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study Completed NCT00512265 Phase 4 n-acetylcysteine;250mL glucose 5%
39 Robust Antibody and Cytokine Response to Hepatitis B Vaccine Among Not-in-treatment Patients With Chronic Hepatitis C:An Open-label Control Study in China Completed NCT02898922 Phase 4
40 Effects on Cytokines, Immunoglobulins, Antibodies, Sphingomyelinase and PAF Hydrolysis Capacity in the Maternal Milk After Probiotic VSL#3 Administration in the Last Four Weeks of Gestation and First Month of Lactation Completed NCT01367470 Phase 4
41 Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal Transplant Completed NCT01239472 Phase 4 Everolimus
42 Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane. Completed NCT01111227 Phase 4 Propofol and isoflurane
43 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney Completed NCT00442819 Phase 4
44 The Effect of Rosiglitazone on Adipocyte-derived Cytokines in Nondiabetics With the Metabolic Syndrome Completed NCT00364221 Phase 4 Rosiglitazone
45 Effects of Pioglitazone and Glimepiride in Hypertensive Patients - Relationship With AGE, Inflammatory Cytokines and Cardiac Markers - Completed NCT01472497 Phase 4 Pioglitazone
46 The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines Completed NCT01089218 Phase 4 oral amoxicillin/clavulanate 1g (875/125mg);control
47 Losartan Improved Insulin Resistance and Decreased Inflammatory Cytokines in Patients With Chronic Heart Failure Treated With Angiotensin Converting Enzyme Inhibitors Completed NCT00663377 Phase 4 losartan
48 A Clinical Study of the Efficacy of Esomeprazole or Rabeprazole on the Pattern of Release of Pro- and Anti-inflammatory Cytokines From Gastric Mucosa of Patients With Peptic Ulcer Disease Completed NCT00534443 Phase 4
49 Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy Completed NCT03164590 Phase 4 Ketamine;dexmedetomidine;bupivacaine
50 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution

Search NIH Clinical Center for Cytokine Deficiency

Genetic Tests for Cytokine Deficiency

Anatomical Context for Cytokine Deficiency

MalaCards organs/tissues related to Cytokine Deficiency:

40
T Cells, Endothelial, Monocytes, Bone Marrow, Neutrophil, Myeloid, Whole Blood

Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

(show top 50) (show all 30019)
# Title Authors PMID Year
1
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue. 61
33522893 2021
2
Goat γδ T cell subpopulations defined by WC1 expression, responses to pathogens and cytokine production. 61
33352199 2021
3
Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury. 61
33229723 2021
4
The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study. 61
33503581 2021
5
A case of COVID-19, with cytokine storm, treated by consecutive use of therapeutic plasma exchange followed by convalescent plasma transfusion: A case report. 61
33107628 2021
6
Longitudinal plasma cytokine concentrations and recurrent wheezing after RSV bronchiolitis. 61
33513527 2021
7
Pyrrolo[2,3-b]quinoxalines in attenuating cytokine storm in COVID-19: their sonochemical synthesis and in silico / in vitro assessment. 61
33424034 2021
8
Skewed intracellular cytokine production of iNKT cells toward Th2-related responses in alloimmunized thalassemia patients. 61
33508653 2021
9
Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis. 61
32572800 2021
10
Retraction notice to <"Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis"> <[Cellular Signaling 17/12 (2005) 1578-1592]>. 61
33454172 2021
11
Zoledronate promotes inflammatory cytokine expression in human CD14-positive monocytes among peripheral mononuclear cells in the presence of γδ T cells. 61
33131052 2021
12
Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-κB p50 as the regulator of cytokine storm. 61
33401144 2021
13
Estimation of lymphocyte subsets and cytokine levels in workers occupationally exposed to cadmium. 61
33248335 2021
14
"Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience", a retrospective study-original article. 61
33585031 2021
15
An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases. 61
33397150 2021
16
Cytokine profile and parasite load in lymph nodes of dogs naturally infected with Leishmania infantum from distinct epidemiological scenarios in São Paulo State, Brazil. 61
33548792 2021
17
Evaluating cytokine production by flow cytometry using brefeldin A in mice. 61
33458706 2021
18
Water extract of Artemisia scoparia Waldst. & Kitam suppresses LPS-induced cytokine production and NLRP3 inflammasome activation in macrophages and alleviates carrageenan-induced acute inflammation in mice. 61
33242622 2021
19
Peri-implantation cytokine profile differs between singleton and twin IVF pregnancies. 61
32946159 2021
20
ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. 61
32826812 2021
21
9‑Hydroxy‑isoegomaketone inhibits LPS‑induced NO and inflammatory cytokine production in RAW264.7 cells. 61
33398364 2021
22
Protocol for mouse trophoblast stem cell isolation, differentiation, and cytokine detection. 61
33458704 2021
23
Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells. 61
32746708 2021
24
Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis. 61
33278457 2021
25
Hierarchical cluster analysis of cytokine profiles reveals a cutaneous vasculitis-associated subgroup in dermatomyositis. 61
32797361 2021
26
The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome. 61
33253913 2021
27
Dynamic cytokine profiles combined with enzyme-linked immunospot assay are useful for immunologically confirming the dapsone hypersensitivity syndrome. 61
32553674 2021
28
Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response. 61
32833183 2021
29
SERINC5 can Enhance Pro-inflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles. 61
33597208 2021
30
The cytokine profile of menstrual blood. 61
32892344 2021
31
Lactate anions participate in T cell cytokine production and function. 61
33580429 2021
32
The cytokine milieu compromises functional capacity of tumor-infiltrating plasmacytoid dendritic cells in HPV-negative but not in HPV-positive HNSCC. 61
33569630 2021
33
Noninvasive assessment of cytokine and antimicrobial peptide levels in hidradenitis suppurativa using transdermal analysis patches. 61
32767746 2021
34
The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. 61
33421362 2021
35
SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions. 61
33064288 2021
36
Cytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent Plasma. 61
33553467 2021
37
Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations. 61
33360025 2021
38
The use of amnion-derived cellular cytokine solution for the treatment of gingivitis: A two week safety, dose-ranging, proof-of-principle randomized trial. 61
33586783 2021
39
Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy. 61
33566210 2021
40
Immunomodulation using CONVEHY® for COVID-19: from the storm to the cytokine anticyclone. 61
33455739 2021
41
Rapid Response to Cytokine Storm Inhibition Using Anakinra in a Patient With COVID-19 Myocarditis. 61
33073222 2021
42
Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition: Posted February 10, 2021. 61
32847819 2021
43
Mesenchymal stromal cell immunomodulation: In pursuit of controlling COVID-19 related cytokine storm. 61
33586320 2021
44
Inflammatory cytokine patterns associated with neurological diseases in COVID-19. 61
33547819 2021
45
An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis. 61
33246770 2021
46
Increased PD-L1 expression may be associated with the cytokine storm and CD8 + T-cell exhaustion in severe COVID-19. 61
33524110 2021
47
Comment on Hu et al: The cytokine storm and COVID-19. 61
32761905 2021
48
Molecular chronicles of cytokine burst in patients with coronavirus disease 2019 (COVID-19) with cardiovascular diseases. 61
32631657 2021
49
Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19. 61
33232817 2021
50
Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned. 61
33333256 2021

Variations for Cytokine Deficiency

Expression for Cytokine Deficiency

Search GEO for disease gene expression data for Cytokine Deficiency.

Pathways for Cytokine Deficiency

Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 IL9 IL5 IL13
2
Show member pathways
12.83 IL9 IL5 IL13
3
Show member pathways
12.78 IL9 IL5 IL13
4
Show member pathways
12.37 IL9 IL5 IL13
5
Show member pathways
11.94 IL9 IL5 IL13
6
Show member pathways
11.9 IL5 IL13
7
Show member pathways
11.79 IL9 IL5 IL13
8
Show member pathways
11.62 IL5 IL13
9 11.42 IL5 IL13
10 11.4 IL9 IL5 IL13
11 11.29 IL5 IL13
12 11.1 IL9 IL5 IL13
13 10.9 IL5 IL13
14 10.84 IL9 IL5 IL13
15 10.56 IL9 IL5 IL13
16 10.55 IL9 IL5 IL13
17 9.88 IL9 IL5 IL13

GO Terms for Cytokine Deficiency

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 IL9 IL5 IL13
2 positive regulation of B cell proliferation GO:0030890 9.26 IL5 IL13
3 inflammatory response GO:0006954 9.13 IL9 IL5 IL13
4 positive regulation of immunoglobulin production GO:0002639 8.62 IL5 IL13

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL9 IL5
2 cytokine receptor binding GO:0005126 8.96 IL9 IL13
3 cytokine activity GO:0005125 8.8 IL9 IL5 IL13

Sources for Cytokine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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