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MCID: CYT002
MIFTS: 42

Cytokine Deficiency

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cytokine Deficiency

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MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 52
Cytokine 17

Classifications:

MalaCards categories:
Global: Rare diseases
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Summaries for Cytokine Deficiency

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MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and proteasome-associated autoinflammatory syndrome 1. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Cilostazol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and monocytes, and related phenotype is digestive/alimentary.

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Related Diseases for Cytokine Deficiency

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Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2486)
# Related Disease Score Top Affiliating Genes
1 asthma 31.4 IL9 IL5 IL13
2 proteasome-associated autoinflammatory syndrome 1 30.6 IL5 IL13
3 dermatitis 30.5 IL5 IL13
4 leishmaniasis 30.4 IL5 IL13
5 autoimmune disease 30.2 IL9 IL5 IL13
6 ige responsiveness, atopic 30.1 IL5 IL13
7 lymphoma, hodgkin, classic 30.1 IL9 IL13
8 sarcoidosis 1 30.1 IL9 IL13
9 meningitis 30.1 IL5 IL13
10 cutaneous leishmaniasis 30.0 IL5 IL13
11 mastocytosis 30.0 IL9 IL13
12 dermatitis, atopic 30.0 IL9 IL5 IL13
13 severe combined immunodeficiency, x-linked 30.0 IL9 IL13
14 bronchiolitis 29.9 IL5 IL13
15 allergic contact dermatitis 29.9 IL9 IL5
16 hypereosinophilic syndrome 29.9 IL9 IL5 IL13
17 allergic asthma 29.8 IL9 IL5 IL13
18 rhinitis 29.8 IL9 IL5 IL13
19 conjunctivitis 29.8 IL5 IL13
20 esophagitis 29.8 IL5 IL13
21 severe combined immunodeficiency 29.8 IL9 IL5 IL13
22 allergic rhinitis 29.8 IL9 IL5 IL13
23 otitis media 29.8 IL5 IL13
24 chronic fatigue syndrome 29.8 IL5 IL13
25 lung disease 29.8 IL9 IL5 IL13
26 inflammatory bowel disease 29.7 IL9 IL5 IL13
27 allergic hypersensitivity disease 29.7 IL9 IL5 IL13
28 keratoconjunctivitis 29.7 IL5 IL13
29 food allergy 29.7 IL5 IL13
30 multiple sclerosis 29.7 IL9 IL5 IL13
31 eosinophilic pneumonia 29.6 IL5 IL13
32 tetanus 29.6 IL9 IL5 IL13
33 pulmonary disease, chronic obstructive 29.6 IL9 IL5 IL13
34 urticaria 29.6 IL5 IL13
35 filarial elephantiasis 29.6 IL5 IL13
36 allergic conjunctivitis 29.5 IL5 IL13
37 pulmonary eosinophilia 29.5 IL5 IL13
38 pollen allergy 29.5 IL5 IL13
39 bullous pemphigoid 29.5 IL5 IL13
40 vernal keratoconjunctivitis 29.5 IL5 IL13
41 diphtheria 29.5 IL5 IL13
42 trichuriasis 29.5 IL9 IL13
43 common cold 29.5 IL5 IL13
44 castleman disease 29.5 IL9 IL5
45 interstitial lung disease 29.4 IL5 IL13
46 mucocutaneous leishmaniasis 29.4 IL5 IL13
47 pulmonary fibrosis, idiopathic 29.4 IL9 IL5 IL13
48 malaria 29.4 IL9 IL5 IL13
49 stevens-johnson syndrome/toxic epidermal necrolysis 29.4 IL5 IL13
50 erythema multiforme 29.4 IL5 IL13

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency
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Symptoms & Phenotypes for Cytokine Deficiency

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MGI Mouse Phenotypes related to Cytokine Deficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9
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Drugs & Therapeutics for Cytokine Deficiency

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Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 967)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
4
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
5
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
6
Dinoprostone Approved Phase 4 363-24-6 5280360
7
Testosterone enanthate Approved Phase 4 315-37-7 9416
8
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
9
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
10
Methyltestosterone Approved Phase 4 58-18-4 6010
11
Citalopram Approved Phase 4 59729-33-8 2771
12
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
13
Levoleucovorin Approved, Investigational Phase 4 68538-85-2
14
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
15
Oxacillin Approved, Investigational Phase 4 66-79-5 6196
16
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
17
Glimepiride Approved Phase 4 93479-97-1 3476
18
Omalizumab Approved, Investigational Phase 4 242138-07-4
19
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
20
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
21
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
22
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
23
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
24
Calcium carbonate Approved, Investigational Phase 4 471-34-1
25
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
26
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
27
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
28
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
29
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
30
silver nitrate Approved, Investigational Phase 4 7761-88-8
31
Silver sulfadiazine Approved, Vet_approved Phase 4 22199-08-2 441244
32
Metformin Approved Phase 4 657-24-9 14219 4091
33
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
34
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
35
Nifedipine Approved Phase 4 21829-25-4 4485
36
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
37
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
38
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 6474909
39
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
40
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
41
Clonidine Approved Phase 4 4205-90-7 2803
42
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
43
Haloperidol Approved Phase 4 52-86-8 3559
44
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
45
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
46
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
47
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
48
Adefovir dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
49
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4 90-89-1 3052
50
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386

Interventional clinical trials:

(show top 50) (show all 3357)
# Name Status NCT ID Phase Drugs
1 The Effects of Intravitral Ozurdex Implant in DME: Cytokine Change in Aqueous Humor Unknown status NCT03475407 Phase 4 Ozurdex intravitreal injection
2 Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations Unknown status NCT01213667 Phase 4 Ranibizumab
3 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
4 Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR Unknown status NCT00289679 Phase 4
5 Mechanisms of Endotoxin-Tolerance of Human Monocytes After CABG-Sugery - Effects of Hemofiltration and Mannitol Treatment Unknown status NCT00426192 Phase 4 i.v. mannitol
6 Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Were Treated With H.P. Acthar Gel After an Incomplete Response to Combinations of DMARDs and Biologic DMRADs Unknown status NCT03082573 Phase 4 H.P. Acthar gel
7 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
8 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
9 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
10 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
11 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
12 The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
13 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
14 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
15 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
16 The Safety and Efficacy of Etanercept in Treating Patient With Acute ST Segment Elevated Myocardial Infarction Unknown status NCT01372930 Phase 4 Etanercept;saline
17 A Prospective, Randomized, Double Blind, Parallel Group Study to Establish the Therapeutic Equivalence of EPIAO® With the Standard Treatment EPREX® in Subjects With Chronic Kidney Disease (CKD) Related Anaemia Not Yet on Dialysis Unknown status NCT02522975 Phase 4 EPIAO®;EPREX®
18 Impact of Vitamin A Supplementation on RAR Gene Expression in PBMC Cells in Multiple Sclerotic Patients Unknown status NCT01705457 Phase 4 Dietary Supplement: vitamin A;placebo
19 Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients Unknown status NCT01417273 Phase 4 Drug: placebo
20 Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis Unknown status NCT02796794 Phase 4
21 Different Day Regimes of Preoperative CONbercept Administration on CytokinEs of Proliferative Diabetic Retinopathy Patients Undergoing Vitrectomy: a Prospective Randomized Controlled Clinical Trial (CONCEPT) Unknown status NCT03506750 Phase 4 IVC
22 Asthma and Vitamin D (a Clinical Pilot Study) Unknown status NCT00712205 Phase 4 Placebo;Calcitriol
23 Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness in Type 2 Diabetes Patient With Metabolic Syndrome (Randomized, Double-Blind, Placebo-Controled, Cross-Over Study) Unknown status NCT00573950 Phase 4 cilostazol;Placebo
24 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
25 Phase 4 Study of the Efficacy of Intralipid Treatment in Patients With Recurrent Implantation Failure and Miscarriages With High Peripheral and Uterine Natural Killer Cells Unknown status NCT01679561 Phase 4 intralipid
26 Short Term Diet Intervention in Newly Diagnosed Type 2 Diabetes. a Randomised, Multicentric, Controlled, Clinical Trial Unknown status NCT01409330 Phase 4
27 Immunological Mechanisms of Oralair® (5 Grass Mix Sublingual Allergen Immunotherapy Tablet) in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
28 The Effects of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring (NuvaRing®) on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
29 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
30 Comparison the Efficacy and Safety of 0.1% Tacrolimus Ointment With 0.1% Mometasone Furoate Cream in the Treatment of Adult Vitiligo: A Single Blinded Pilot Study Unknown status NCT01333410 Phase 4 tacrolimus ointment;Mometasone furoate
31 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
32 Effects of the Use of "de Novo" Everolimus for the Expression of Cytokines in Kidneys From Extended Criteria Donors and With Delayed Graft Function Unknown status NCT01663805 Phase 4 Everolimus
33 Rifaximin Predicts the Complications of Decompensated Cirrhosis: a Randomized Controlled Trial Unknown status NCT02074280 Phase 4 rifaximin
34 Rifaximin Reduces the Complications of Decompensated Cirrhosis Unknown status NCT02190357 Phase 4 Rifaximin
35 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission: a Prospective, Pilot Study. Unknown status NCT03244709 Phase 4 Tocilizumab
36 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
37 Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma Unknown status NCT00307606 Phase 4 Solu-medrol 125 mg
38 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
39 Granulocyte Colony Stimulating Factor Plus N-Acetyl Cysteine In Severe Alcoholic Hepatitis Unknown status NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
40 Phase 4 Study: Comparison of Myfortic and Early Rapamycin Conversion vs. Low-Dose Tacrolimus in Preventing Acute Rejection and Chronic Allograft Fibrosis: A Protocol Biopsy Directed Approach Unknown status NCT00896012 Phase 4 Rapamune (sirolimus/rapamycin);Tacrolimus
41 A Clinical Study of Biomarkers of Innate and Adaptive Immune Activation Associated With Symptoms and Immune Responses After Administration of a Single Dose of a Quadrivalent Inactivated Split Virus Influenza Vaccine to Healthy Young Adults. Unknown status NCT03160118 Phase 4 Seasonal,quadrivalent,influenza vaccine
42 The Effect of Selenium Supplementation Among Pediatric Patients With Burns Unknown status NCT00860379 Phase 4 Selenium1;Selenium2;Placebo
43 Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau Unknown status NCT00168610 Phase 4 Vitamin A
44 The Influence of BCG Vaccine as a Booster TDaP-IPV Vaccination: an Explorative Study Unknown status NCT02771782 Phase 4
45 Phase 4 Clinical Trial to Examine the Role of Rosuvastatin and Exercise Treatment in Modulating Inflammatory Response in Hypercholesterolemic Subjects Unknown status NCT00295373 Phase 4 Rosuvastatin
46 Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau Unknown status NCT02953327 Phase 4
47 The Impact of Conventional Hemodialysis, High Flux Hemodialysis and Hemodiafiltration on Adiponectin, Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
48 A Pilot Study to Evaluate the Efficacy and Safety of Pegylated Interferon Alfa-2b Plus Ribavirin in the Treatment of Patients With Dual Chronic Hepatitis B and Delta Unknown status NCT00117533 Phase 4 pegylated IFN alfa-2b plus ribavirin
49 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
50 Advair - CRP Study Unknown status NCT00120978 Phase 4 Advair;Flovent

Search NIH Clinical Center for Cytokine Deficiency

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Genetic Tests for Cytokine Deficiency

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Anatomical Context for Cytokine Deficiency

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MalaCards organs/tissues related to Cytokine Deficiency:

40
T Cells, Lung, Monocytes, Liver, Breast, Bone, Endothelial
Sources

Publications for Cytokine Deficiency

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Articles related to Cytokine Deficiency:

(show top 50) (show all 30020)
# Title Authors PMID Year
1
The Immunomodulatory Effect of Radiofrequency Electromagnetic Field on Serum Cytokine Levels in A Mouse Model of Hindlimb Unloading. 61
32347032 2021
2
Cytokine Gene Expression Alterations in Human Macrophages Infected by Leishmania major. 61
32347041 2021
3
Is there a role for blood purification therapies targeting cytokine storm syndrome in critically severe COVID-19 patients? 61
32438839 2020
4
Inhibition Human Nasopharyngeal Carcinoma Cells TNF-α Gene Transfected Cytokine-Induced Killer Cells Based on Nanomaterial Polyphthalamide Monoamine Dendrimer Nanomaterial. 61
32384962 2020
5
Neuropeptide and cytokine regulation of pain in the context of substance use disorders. 61
32470337 2020
6
The effects of intraoperative hypothermia on cytokine profile: A randomized pilot study. 61
32179395 2020
7
Peroxisome proliferator-activated receptor β/δ and γ agonists differentially affect prostaglandin E2 and cytokine synthesis and nutrient transporter expression in porcine trophoblast cells during implantation. 61
32361305 2020
8
Association of cytokine patterns and clinical/laboratory parameters, medication and periodontal burden in patients with rheumatoid arthritis (RA). 61
32300908 2020
9
Particulate matter exposure disturbs inflammatory cytokine homeostasis associated with changes in trace metal levels in mouse organs. 61
32330707 2020
10
Early cytokine response to lethal challenge of Klebsiella pneumoniae averted the prognosis of pneumonia in FyuA immunized mice. 61
32194179 2020
11
Activation of Transient Receptor Potential Melastatin Family Member 8 (TRPM8) Receptors Induces Proinflammatory Cytokine Expressions in Bronchial Epithelial Cells. 61
32400133 2020
12
Cytokine profile during pregnancy predicts relapses during pregnancy and postpartum in multiple sclerosis. 61
32278167 2020
13
Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells. 61
32217132 2020
14
Utilizing tocilizumab for the treatment of cytokine release syndrome in COVID-19. 61
32425661 2020
15
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions. 61
32376392 2020
16
Cyclosporine therapy in cytokine storm due to coronavirus disease 2019 (COVID-19). 61
32415310 2020
17
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? 61
32291137 2020
18
Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019? 61
32314868 2020
19
Comparison of cytokine profiles between anti-ARS antibody-positive interstitial lung diseases and those with anti-MDA-5 antibodies. 61
32056068 2020
20
Electric Stimulation Hyperthermia Relieves Inflammation via the Suppressor of Cytokine Signaling 3-Toll Like Receptor 4 Pathway in a Prostatitis Rat Model. 61
31385476 2020
21
Capsid proteins of foot-and-mouth disease virus interact with TLR2 and CD14 to induce cytokine production. 61
32333963 2020
22
Cytokine mRNA and protein expression by cell cultures of epithelial ovarian cancer-Methodological considerations on the choice of analytical method for cytokine analyses. 61
32307767 2020
23
A fish cytokine related to human IL-3, IL-5, and GM-CSF, induces development of eosinophil/basophil/mast-cell type (EBM) granulocytes. 61
32147469 2020
24
Cytokine storm syndrome in severe COVID-19. 61
32376400 2020
25
Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? 61
32376396 2020
26
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment. 61
32474885 2020
27
Monophosphoryl lipid A pretreatment suppresses sepsis- and LPS-induced proinflammatory cytokine production in the medullary thick ascending limb. 61
32421349 2020
28
Dendritic Cells Therapy with Cytokine-Induced Killer Cells and Activated Cytotoxic T Cells Attenuated Th2 Bias Immune Response. 61
31793363 2020
29
Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation. 61
32047272 2020
30
Influence of plasma cytokine levels on the conversion risk from MCI to dementia in the Alzheimer's disease neuroimaging initiative database. 61
32289574 2020
31
Amoxicillin-induced gut dysbiosis influences estrous cycle in mice and cytokine expression in the ovary and the caecum. 61
32304259 2020
32
Characterization of casein-derived peptide bioactivity: Differential effects on angiotensin-converting enzyme inhibition and cytokine and nitric oxide production. 61
32448573 2020
33
Subacute exposure of PM2.5 induces airway inflammation through inflammatory cell infiltration and cytokine expression in rats. 61
32171134 2020
34
Progesterone inhibits cytokine/TNF-α production by porcine CL macrophages via the genomic progesterone receptor. 61
32244110 2020
35
Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: An exploratory study. 61
32135194 2020
36
Photobiomodulation of inflammatory-cytokine-related effects in a 3-D culture model with gingival fibroblasts. 61
32030556 2020
37
Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles. 61
32248539 2020
38
Low levels of serum vitamin D in clozapine-treated schizophrenia patients are associated with high levels of the proinflammatory cytokine IL-6. 61
31913874 2020
39
Effect of cytokine treatment on the expression and secretion of brain derived neurotrophic factor in the smooth muscle of the rat colon. 61
32440350 2020
40
Effects of lithium on cytokine neuro-inflammatory mediators, Wnt/β-catenin signaling and microglial activation in the hippocampus of chronic mild stress-exposed rats. 61
32454056 2020
41
Methyl mercury (MeHg) in vitro exposure alters mitogen-induced lymphocyte proliferation and cytokine expression in Steller sea lion (Eumetopias jubatus) pups. 61
32302832 2020
42
TIMP-1: A key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease. 61
32194232 2020
43
Application of the chemokine-chemokine receptor axis increases the tumor-targeted migration ability of cytokine-induced killer cells in patients with colorectal cancer. 61
32565940 2020
44
Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry. 61
32380407 2020
45
Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells. 61
32315671 2020
46
Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice. 61
32416449 2020
47
Smoke exposure from chronic biomass burning induces distinct accumulative systemic inflammatory cytokine alterations compared to tobacco smoking in healthy women. 61
32283440 2020
48
Photobiomodulation reduces cell death and cytokine production in C2C12 cells exposed to Bothrops venoms. 61
31754908 2020
49
Temporal analysis of histopathology and cytokine expression in the rat cerebral cortex after insulin-induced hypoglycemia. 61
32080930 2020
50
Comparison of serum cytokine concentrations between healthy dogs and canine osteosarcoma patients at the time of diagnosis. 61
32559421 2020
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Variations for Cytokine Deficiency

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Expression for Cytokine Deficiency

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Search GEO for disease gene expression data for Cytokine Deficiency.
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Pathways for Cytokine Deficiency

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Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 63
Show member pathways
 12.88 IL9 IL5 IL13
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.83 IL9 IL5 IL13
3
PAK Pathway 63
Show member pathways
 12.78 IL9 IL5 IL13
4
Allograft rejection 1 36
Show member pathways
 12.37 IL9 IL5 IL13
5
Apoptosis Pathway 70
Show member pathways
 12 IL5 IL13
6
JAK-STAT signaling pathway 36
Show member pathways
 11.98 IL9 IL5 IL13
7
IL-17 Family Signaling Pathways 64
Show member pathways
 11.9 IL5 IL13
8
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.75 IL9 IL5 IL13
9
MAPK Pathway 70
Show member pathways
 11.62 IL5 IL13
10
Glucocorticoid receptor regulatory network 1
11.42 IL5 IL13
11
Innate Lymphoid Cells Differentiation 64
11.4 IL9 IL5 IL13
12
Lung fibrosis 1
11.29 IL5 IL13
13
Th2 Differentiation 64
11.1 IL9 IL5 IL13
14
Cytokines and Inflammatory Response 1
10.9 IL5 IL13
15
Development and heterogeneity of the ILC family 1
10.84 IL9 IL5 IL13
16
G-protein signaling_Rap2B regulation pathway 22
10.56 IL9 IL5 IL13
17
OX40 Pathway 63
10.55 IL9 IL5 IL13
18
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
9.88 IL9 IL5 IL13
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GO Terms for Cytokine Deficiency

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Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of B cell proliferation GO:0030890 9.16 IL5 IL13
2 immune response GO:0006955 9.13 IL9 IL5 IL13
3 inflammatory response GO:0006954 8.8 IL9 IL5 IL13

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL9 IL5
2 cytokine receptor binding GO:0005126 8.96 IL9 IL13
3 cytokine activity GO:0005125 8.8 IL9 IL5 IL13
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Sources for Cytokine Deficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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