MCID: CYT002
MIFTS: 43

Cytokine Deficiency

Categories: Rare diseases

Aliases & Classifications for Cytokine Deficiency

MalaCards integrated aliases for Cytokine Deficiency:

Name: Cytokine Deficiency 20
Cytokine 17

Classifications:



External Ids:

Summaries for Cytokine Deficiency

MalaCards based summary : Cytokine Deficiency, also known as cytokine, is related to asthma and severe combined immunodeficiency. An important gene associated with Cytokine Deficiency is IL13 (Interleukin 13), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and monocytes, and related phenotype is digestive/alimentary.

Wikipedia : 73 Cytokines are a broad and loose category of small proteins (~5-20 kDa) important in cell signaling.... more...

Related Diseases for Cytokine Deficiency

Diseases related to Cytokine Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2168)
# Related Disease Score Top Affiliating Genes
1 asthma 30.9 IL9 IL5 IL13
2 severe combined immunodeficiency 30.8 IL9 IL13
3 proteasome-associated autoinflammatory syndrome 1 30.8 IL5 IL13
4 dermatitis 30.7 IL5 IL13
5 leishmaniasis 30.6 IL5 IL13
6 pneumonia 30.4 IL5 IL13
7 ige responsiveness, atopic 30.4 IL5 IL13
8 contact dermatitis 30.4 IL9 IL5
9 autoimmune disease 30.4 IL9 IL5 IL13
10 dermatitis, atopic 30.3 IL9 IL5 IL13
11 meningitis 30.3 IL5 IL13
12 lymphoma, hodgkin, classic 30.3 IL9 IL13
13 leprosy 3 30.3 IL5 IL13
14 hypereosinophilic syndrome 30.3 IL9 IL5 IL13
15 sarcoidosis 1 30.3 IL9 IL13
16 allergic contact dermatitis 30.3 IL9 IL5
17 allergic disease 30.2 IL9 IL5 IL13
18 cutaneous leishmaniasis 30.2 IL5 IL13
19 allergic asthma 30.2 IL9 IL5 IL13
20 rhinitis 30.2 IL9 IL5 IL13
21 allergic rhinitis 30.2 IL9 IL5 IL13
22 severe combined immunodeficiency, x-linked 30.1 IL9 IL13
23 mastocytosis 30.1 IL9 IL13
24 tetanus 30.1 IL9 IL5 IL13
25 chronic fatigue syndrome 30.0 IL5 IL13
26 conjunctivitis 30.0 IL5 IL13
27 esophagitis 30.0 IL5 IL13
28 inflammatory bowel disease 30.0 IL9 IL5 IL13
29 lung disease 30.0 IL9 IL5 IL13
30 multiple sclerosis 30.0 IL9 IL5 IL13
31 schistosomiasis 30.0 IL9 IL5 IL13
32 pemphigoid 30.0 IL5 IL13
33 keratoconjunctivitis 29.9 IL5 IL13
34 food allergy 29.9 IL5 IL13
35 bronchiolitis 29.9 IL9 IL5 IL13
36 pulmonary disease, chronic obstructive 29.9 IL9 IL5 IL13
37 eosinophilic pneumonia 29.9 IL5 IL13
38 pollen allergy 29.8 IL5 IL13
39 diphtheria 29.8 IL5 IL13
40 malaria 29.8 IL9 IL5 IL13
41 common cold 29.8 IL5 IL13
42 pulmonary eosinophilia 29.8 IL5 IL13
43 trichuriasis 29.8 IL9 IL13
44 bullous pemphigoid 29.8 IL5 IL13
45 respiratory allergy 29.7 IL5 IL13
46 pulmonary fibrosis, idiopathic 29.7 IL9 IL5 IL13
47 chronic asthma 29.7 IL5 IL13
48 urticaria 29.7 IL5 IL13
49 allergic conjunctivitis 29.7 IL5 IL13
50 combined immunodeficiency 29.7 IL9 IL5 IL13

Graphical network of the top 20 diseases related to Cytokine Deficiency:



Diseases related to Cytokine Deficiency

Symptoms & Phenotypes for Cytokine Deficiency

MGI Mouse Phenotypes related to Cytokine Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 IL13 IL5 IL9

Drugs & Therapeutics for Cytokine Deficiency

Drugs for Cytokine Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 568)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
3
Adalimumab Approved, Experimental Phase 4 331731-18-1 16219006
4
Atenolol Approved Phase 4 29122-68-7 2249
5
Etanercept Approved, Investigational Phase 4 185243-69-0
6
Infliximab Approved Phase 4 170277-31-3
7
Iron Approved Phase 4 7439-89-6 23925 29936
8
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
9
Tacrolimus Approved, Investigational Phase 4 104987-11-3 6473866 445643 439492
10
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
11
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
12
Mycophenolic acid Approved Phase 4 24280-93-1 446541
13
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
14
Fluorouracil Approved Phase 4 51-21-8 3385
15
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
16
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
19
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
20
Nifedipine Approved Phase 4 21829-25-4 4485
21
Glimepiride Approved Phase 4 93479-97-1 3476
22
Copper Approved, Investigational Phase 4 7440-50-8 27099
23
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
24
leucovorin Approved Phase 4 58-05-9 6006
25
Citalopram Approved Phase 4 59729-33-8 2771
26
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
27
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
28
Azithromycin Approved Phase 4 83905-01-5 447043 55185
29
Omalizumab Approved, Investigational Phase 4 242138-07-4
30
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
31
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
32
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
33
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
34
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
35
Losartan Approved Phase 4 114798-26-4 3961
36
Esomeprazole Approved, Investigational Phase 4 161973-10-0, 161796-78-7, 119141-88-7 4594 9568614
37
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
38
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
39
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
40
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
41
Ethambutol Approved Phase 4 74-55-5 3279 14052
42
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
43
Ranibizumab Approved Phase 4 347396-82-1 459903
44
Remifentanil Approved Phase 4 132875-61-7 60815
45
Temozolomide Approved, Investigational Phase 4 85622-93-1 5394
46
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
47
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
48
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
49
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
50
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919

Interventional clinical trials:

(show top 50) (show all 986)
# Name Status NCT ID Phase Drugs
1 The Effects of Intravitral Ozurdex Implant in DME: Cytokine Change in Aqueous Humor Unknown status NCT03475407 Phase 4 Ozurdex intravitreal injection
2 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
3 Cytokine Profile and Metal Ion Concentrations at Patients Undergoing a Revision THR Unknown status NCT00289679 Phase 4
4 Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations Unknown status NCT01213667 Phase 4 Ranibizumab
5 Intervention Study Measuring Inflammatory Cytokine Levels in the Serum of Patients Who Underwent an Acute MI, and the Influence of Vitamin D on These Levels Unknown status NCT01115842 Phase 4 Vitamin D
6 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
7 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
8 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
9 The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients Unknown status NCT01407211 Phase 4
10 The Effect of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by T CD4+ Lymphocyte in Atherosclerotic Patients Unknown status NCT01414972 Phase 4 Vitamin A;placebo
11 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
12 The Effect of Perioperative Atenolol on Post-Operative Cytokines Unknown status NCT00202358 Phase 4 atenolol;placebo
13 Effect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With Sepsis Unknown status NCT02796794 Phase 4
14 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
15 Different Day Regimes of Preoperative CONbercept Administration on CytokinEs of Proliferative Diabetic Retinopathy Patients Undergoing Vitrectomy: a Prospective Randomized Controlled Clinical Trial (CONCEPT) Unknown status NCT03506750 Phase 4 IVC
16 Prevention of Pro-inflammatory Cytokines-associated Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block Unknown status NCT02144766 Phase 4 ropivacaine;saline
17 Effects of the Use of "de Novo" Everolimus for the Expression of Cytokines in Kidneys From Extended Criteria Donors and With Delayed Graft Function Unknown status NCT01663805 Phase 4 Everolimus
18 Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
19 Impact of Probiotics on the Intestinal Microbiota and Its Association With Postoperative Outcome After Colorectal Surgery Completed NCT01609660 Phase 4
20 A Phase 4 Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis Completed NCT03331835 Phase 4 Fumaric acid esters
21 Effect of Preemptive Epidural Analgesia in Labor on Pro and Anti-inflammatory Cytokine Production in a Mother and a Newborn Completed NCT00361712 Phase 4 Standard of care
22 TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience Completed NCT04730323 Phase 4 Tocilizumab
23 EFFECTS OF NSAIDs ON CLINICAL OUTCOMES, SYNOVIAL FLUID CYTOKINE CONCENTRATION AND SIGNAL TRANSDUCTION PATHWAYS IN KNEE OSTEOARTHRITIS Completed NCT01860833 Phase 4 Ibuprofen;Celecoxib;Diclofenac
24 Effects of Fingolimod (Gilenya®) on Cytokine and Chemokine Levels in Relapsing Remitting Multiple Sclerosis Patients Completed NCT02373098 Phase 4 Fingolimod 0.5 mg
25 Recurrent Urinary Tract Infections in Children: Bacterial Identification, Antibiotic Susceptibility Profiling and Cytokine Levels Associated With Antibiotic Prophylaxis Completed NCT02357758 Phase 4 Antibiotic Prophylaxis
26 The Effect of Zinc, Beta-carotene, and Vitamin D3 Supplementation as Pro-inflammation Mediated Regulator in Preterm Delivery Through Placental Protein Adaptor MyD88 and TRIF, Transcription Factor NFkB, and Pro-inflammatory Cytokine IL-1β Completed NCT03005496 Phase 4 Zinc;Nifedipine;Beta Carotene;Vitamin D3;Dexamethasone
27 TNF-α Blockade for Psoriatic Arthritis - A Clinical and MRI Study, and the Effects on Cytokine and Cardiovascular Risk Profile Completed NCT00432406 Phase 4 Infliximab;Etanercept
28 Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans. Completed NCT00431691 Phase 4 vitamin and mineral supplement;Escherichia coli Endotoxin (LPS);100% O2;nitroglycerin
29 Phenotype and Cytokine Production Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Aldara 5% Cream Using Flow Cytometry Completed NCT00176943 Phase 4 Aldara Cream 5%
30 Clinical Efficacy of Chemotherapy Combined With Cytokine-induced Killer in Treatment of Patients With Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
31 The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression Completed NCT00254020 Phase 4 Citalopram
32 Preoperative Versus Postoperative Ultrasound-guided Rectus Sheath Block for Improving Pain, Sleep Quality and Cytokine Levels of Patients With Open Midline Incisions Undergoing Transabdominal Gynaecological Operation Completed NCT02477098 Phase 4 preoperative 0.5% ropivacaine hydrochloride preoperative;postoperative 0.5% Ropivacaine hydrochloride
33 Anti Cytokine Combination Therapy With Daclizumab and Infliximab for Treatment of Steroid Refractory Acute GVHD Completed NCT00574470 Phase 4 daclizumab, infliximab
34 A Multi-Center, Open-Label Study Evaluating the Cytokine and Eyelid Margin Bacterial Load Levels of Subjects Diagnosed With Chronic Blepharitis Following Dosing With AzaSite® (Azithromycin Ophthalmic Solution) 1% Completed NCT00629941 Phase 4 AzaSite®
35 The Effect of Xolair (Omalizumab) on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Completed NCT00657891 Phase 4 Omalizumab;Placebo
36 Robust Antibody and Cytokine Response to Hepatitis B Vaccine Among Not-in-treatment Patients With Chronic Hepatitis C:An Open-label Control Study in China Completed NCT02898922 Phase 4
37 The Effect of Preoperative Topical Ketorolac 0.45% on Aqueous Cytokine Levels and Macular Thickness in Diabetic and Non Diabetic Patients Undergoing Cataract Surgery Completed NCT02646072 Phase 4 Ketorolac tromethamine ophthalmic solution 0.45%
38 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Treatment Naïve Patients With Diabetic Macular Edema Completed NCT02441907 Phase 4 aflibercept
39 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study Completed NCT00512265 Phase 4 n-acetylcysteine;250mL glucose 5%
40 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney Completed NCT00442819 Phase 4
41 Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal Transplant Completed NCT01239472 Phase 4 Everolimus
42 Effects of Pioglitazone and Glimepiride in Hypertensive Patients - Relationship With AGE, Inflammatory Cytokines and Cardiac Markers - Completed NCT01472497 Phase 4 Pioglitazone
43 The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines Completed NCT01089218 Phase 4 oral amoxicillin/clavulanate 1g (875/125mg);control
44 The Effect of Rosiglitazone on Adipocyte-derived Cytokines in Nondiabetics With the Metabolic Syndrome Completed NCT00364221 Phase 4 Rosiglitazone
45 Effect of Anti-interleukin 5 (IL5) Therapy on Sputum Cells and Cytokines Completed NCT04412044 Phase 4 Mepolizumab Injection [Nucala]
46 Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy Completed NCT03164590 Phase 4 Ketamine;dexmedetomidine;bupivacaine
47 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution
48 Analysis of Cytokines in Response to Treatment of Diabetic Macular Edema With 0.3mg Lucentis Completed NCT03097068 Phase 4 Lucentis
49 The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block on Plasma Cortisol and Pain-related Cytokines After Arthroscopic Rotator Cuff Repair: a Randomized Controlled Trial Completed NCT04398589 Phase 4 Dexmedetomidine injection;Saline injection
50 Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane. Completed NCT01111227 Phase 4 Propofol and isoflurane

Search NIH Clinical Center for Cytokine Deficiency

Genetic Tests for Cytokine Deficiency

Anatomical Context for Cytokine Deficiency

MalaCards organs/tissues related to Cytokine Deficiency:

40
T Cells, Endothelial, Monocytes, Bone Marrow, Neutrophil, Myeloid, Whole Blood

Publications for Cytokine Deficiency

Articles related to Cytokine Deficiency:

(show top 50) (show all 30020)
# Title Authors PMID Year
1
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue. 61
33522893 2021
2
The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death. 61
33662571 2021
3
Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury. 61
33229723 2021
4
Cytokine release syndrome and complete remission of extra medullary acute lymphoblastic leukemia of the breast with CAR-T and radiation therapy. 61
33258192 2021
5
Machine learning-based cytokine microarray digital immunoassay analysis. 61
33647790 2021
6
The suppression of IL-17 production from T cells by gallate-type procyanidin is mediated by selectively inhibiting cytokine production from dendritic cells. 61
33556876 2021
7
Macrophage inhibitory cytokine-1 promotes angiogenesis by eliciting the GFRAL-mediated endothelial cell signaling. 61
33151561 2021
8
Development of a cytokine gene expression assay for the relative quantification of the African elephant (Loxodonta africana) cell-mediated immune responses. 61
33548797 2021
9
Goat γδ T cell subpopulations defined by WC1 expression, responses to pathogens and cytokine production. 61
33352199 2021
10
Cytokine secretion and pyroptosis of cholesteatoma keratinocytes mediated by AIM2 inflammasomes in response to cytoplasmic DNA. 61
33760111 2021
11
The dynamics of select cellular responses and cytokine expression profiles in mice infected with juvenile Clonorchis sinensis. 61
33548205 2021
12
Predictive value of cytokine/chemokine responses for the disease severity and management in children and adult cases with COVID-19. 61
33225509 2021
13
Cytokine profile and glial activation following brachial plexus roots avulsion injury in mice. 61
33582398 2021
14
ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. 61
33723527 2021
15
Cytokine-mediated induction of human xylosyltransferase-I in systemic sclerosis skin fibroblasts. 61
33662666 2021
16
Modulation of cytokine production by monocytes and developing-dendritic cells under the influence of leukemia and lymphoma cell products. 61
33289218 2021
17
Response to letter to the editor "The impact of cytokine change after hepatitis C virus clearance by direct antiviral agents on the risk of hepatocellular carcinoma". 61
33358562 2021
18
The impact of cytokine change after hepatitis C virus clearance by direct antiviral agents on the risk of hepatocellular carcinoma. 61
33293200 2021
19
Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer: A meta-analysis. 61
33787569 2021
20
Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis. 61
32572800 2021
21
Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm. 61
33033851 2021
22
Cytokine storm induced by a PD1 inhibitor in a renal transplant patient. 61
33797848 2021
23
Cytokine "fine tuning" of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies. 61
33544244 2021
24
Circulating cytokine levels in the treatment of comorbid anxiety disorders. 61
33109296 2021
25
Response to: Letter to the Editor on "Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine Growth Factor Rev" by Eugenia Quiros-Roldan, Giorgio Biasiotto and Isabella Zanella. 61
32718829 2021
26
Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time. 61
33202033 2021
27
Retraction notice to <"Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis"> <[Cellular Signaling 17/12 (2005) 1578-1592]>. 61
33454172 2021
28
Cytokine trafficking of IL-9 and IL-13 through TfnRc+ vesicles in activated human eosinophils. 61
32911568 2021
29
Cytokine Levels and Symptoms Among Women with Irritable Bowel Syndrome: Considering the Role of Hormonal Contraceptive Use. 61
32677464 2021
30
Lipoteichoic acid stimulates the proliferation, migration and cytokine production of adult dental pulp stem cells without affecting osteogenic differentiation. 61
33210765 2021
31
Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells. 61
33048222 2021
32
What Is a Cytokine Storm and Should It Matter to Me? 61
33443384 2021
33
Biomarkers for Predicting Cytokine Release Syndrome following CD19-Targeted CAR T Cell Therapy. 61
33692146 2021
34
Model of Magnetic Particle Capture Under Physiological Flow Rates for Cytokine Removal During Cardiopulmonary Bypass. 61
32915721 2021
35
Toll-like receptor activation of equine mesenchymal stromal cells to enhance antibacterial activity and immunomodulatory cytokine secretion. 61
33797775 2021
36
Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals. 61
33795689 2021
37
CaMKIIδ is upregulated by pro-inflammatory cytokine IL-6 in a JAK/STAT3-dependent manner to promote angiogenesis. 61
33749880 2021
38
Hypothermia Attenuates Neuronal Damage via Inhibition of Microglial Activation, Including Suppression of Microglial Cytokine Production and Phagocytosis. 61
32382852 2021
39
Are all cytokine storms the same? 61
33416946 2021
40
The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms. 61
33597149 2021
41
Fat infiltration in the multifidus muscle is related to inflammatory cytokine expression in the muscle and epidural adipose tissue in individuals undergoing surgery for intervertebral disc herniation. 61
32594231 2021
42
Polarized cytokine release from airway epithelium differentially influences macrophage phenotype. 61
33588245 2021
43
Extracellular cardiolipin modulates microglial phagocytosis and cytokine secretion in a toll-like receptor (TLR) 4-dependent manner. 61
33517251 2021
44
Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm. 61
32862238 2021
45
Skewed intracellular cytokine production of iNKT cells toward Th2-related responses in alloimmunized thalassemia patients. 61
33508653 2021
46
Cytokine inducible SH2-containing protein potentiate J subgroup avian leukosis virus replication and suppress antiviral responses in DF-1 chicken fibroblast cells. 61
33636239 2021
47
Chlamydia trachomatis glycogen synthase promotes MAPK-mediated proinflammatory cytokine production via TLR2/TLR4 in THP-1 cells. 61
33581128 2021
48
AQUEOUS HUMOR CYTOKINE LEVELS AND REBOUND MACULAR EDEMA AFTER CONBERCEPT TREATMENT IN PATIENTS WITH CENTRAL RETINAL VEIN OCCLUSION. 61
33755650 2021
49
Altered cytokine responses in children with cerebral palsy: pathogenesis and novel therapies. 61
33533040 2021
50
Cytokine dysregulation in children with cerebral palsy. 61
33185287 2021

Variations for Cytokine Deficiency

Expression for Cytokine Deficiency

Search GEO for disease gene expression data for Cytokine Deficiency.

Pathways for Cytokine Deficiency

Pathways related to Cytokine Deficiency according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 IL9 IL5 IL13
2
Show member pathways
12.83 IL9 IL5 IL13
3
Show member pathways
12.78 IL9 IL5 IL13
4
Show member pathways
12.37 IL9 IL5 IL13
5
Show member pathways
11.94 IL9 IL5 IL13
6
Show member pathways
11.9 IL5 IL13
7
Show member pathways
11.79 IL9 IL5 IL13
8
Show member pathways
11.62 IL5 IL13
9 11.42 IL5 IL13
10 11.4 IL9 IL5 IL13
11 11.29 IL5 IL13
12 11.1 IL9 IL5 IL13
13 10.9 IL5 IL13
14 10.84 IL9 IL5 IL13
15 10.56 IL9 IL5 IL13
16 10.55 IL9 IL5 IL13
17 9.88 IL9 IL5 IL13

GO Terms for Cytokine Deficiency

Biological processes related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 IL9 IL5 IL13
2 positive regulation of B cell proliferation GO:0030890 9.26 IL5 IL13
3 inflammatory response GO:0006954 9.13 IL9 IL5 IL13
4 positive regulation of immunoglobulin production GO:0002639 8.62 IL5 IL13

Molecular functions related to Cytokine Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 IL9 IL5
2 cytokine receptor binding GO:0005126 8.96 IL9 IL13
3 cytokine activity GO:0005125 8.8 IL9 IL5 IL13

Sources for Cytokine Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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