MCID: DCR003
MIFTS: 44

Dacryoadenitis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Dacryoadenitis

MalaCards integrated aliases for Dacryoadenitis:

Name: Dacryoadenitis 12 54 15 71 32
Dacryocystitis 44 71

Classifications:



External Ids:

Disease Ontology 12 DOID:950
ICD9CM 34 375.0
MeSH 44 D003607
NCIt 50 C26971
SNOMED-CT 67 86927009
ICD10 32 H04.0
UMLS 71 C0010930 C0155223

Summaries for Dacryoadenitis

MalaCards based summary : Dacryoadenitis, also known as dacryocystitis, is related to mikulicz disease and igg4-related disease. An important gene associated with Dacryoadenitis is IL21 (Interleukin 21), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ophthalmic Solutions and Proxymetacaine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and lymph node, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 74 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing... more...

Related Diseases for Dacryoadenitis

Diseases in the Dacryoadenitis family:

Chronic Dacryoadenitis Acute Dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 621)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 32.0 IL4 IL13 IL10 CD4 CCR6
2 igg4-related disease 30.8 IL4 ICOSLG CCR6
3 sialadenitis 30.4 SPTAN1 ICOSLG CD4 CCR6 BPIFA2
4 cellulitis 30.3 CD8A CD4 CCR6
5 sarcoidosis 1 30.2 IL13 ICOSLG CD8A CD4 CCR6
6 dry eye syndrome 30.2 LACRT CCR6 AQP5
7 keratoconjunctivitis 30.2 IL4 IL17A IL13
8 pfeiffer syndrome 30.1 CD8A CD4 CCR6
9 keratitis, hereditary 30.0 IL17A IL10 CD8A CD4 CCR6
10 uveitis 30.0 IL4 IL17A IL10
11 vaginitis 30.0 IL10 CD4 CCR6
12 herpes zoster 29.9 IL10 ICOSLG CD8A CD4 CCR6
13 iridocyclitis 29.9 IL17A IL10 CD8A CD4
14 churg-strauss syndrome 29.9 PRTN3 IL17A IL10
15 blepharoconjunctivitis 29.9 IL4 CD4
16 blastomycosis 29.9 IL17A CD4 CCR6
17 urethritis 29.9 IL10 CD8A CD4
18 conjunctivitis 29.9 IL4 IL13 IL10 FOXP3
19 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.8 IL17A IL10 FOXP3
20 tularemia 29.8 IL17A CD8A CD4 CCR6
21 oral candidiasis 29.8 IL17A CD4 CCR6
22 sjogren syndrome 29.8 SPTAN1 PRTN3 IL10 AQP5
23 mature t-cell and nk-cell lymphoma 29.8 ICOSLG CD8A CD4 CCR6
24 cysticercosis 29.7 IL4 IL10 CD4
25 subcutaneous mycosis 29.6 IL17A IL10 CD4 CCR6
26 aortitis 29.6 PRTN3 IL17A CD4
27 autoimmune cholangitis 29.6 IL17A CD8A CD4 CCR6
28 candidiasis 29.6 IL4 IL17A IL10
29 chlamydia 29.6 IL4 IL17A IL10
30 scleritis 29.6 PRTN3 IL4 CCR6
31 trachoma 29.5 IL4 IL17A IL10
32 autoimmune uveitis 29.5 IL4 IL17A IL10
33 lymphadenitis 29.5 IL10 ICOSLG CD8A CD4 CCR6
34 brucellosis 29.5 IL4 IL17A IL13 IL10
35 allergic conjunctivitis 29.5 IL4 IL13 IL10 FOXP3
36 granulomatosis with polyangiitis 29.5 PRTN3 ICOSLG FOXP3 CD4 CCR6
37 thyroiditis 29.4 IL4 IL17A IL10 FOXP3
38 autoimmune pancreatitis 29.4 SPTAN1 IL17A IL10 FOXP3 CD4
39 reactive arthritis 29.4 PRTN3 IL17A IL10 CCR6
40 iritis 29.4 IL17A IL10 CD8A CD4 CCR6
41 severe combined immunodeficiency 29.3 IL4 IL21 IL17A IL13 IL10
42 schistosomiasis 29.3 IL4 IL17A IL13 IL10
43 allergic rhinitis 29.2 IL4 IL17A IL13 IL10
44 blepharitis 29.2 LACRT IL4 CD8A CD4 CCR6
45 mucocutaneous leishmaniasis 29.2 IL4 IL13 IL10 CD8A CD4
46 chickenpox 29.1 IL4 IL10 ICOSLG CD8A CD4 CCR6
47 exanthem 29.1 PRTN3 IL10 ICOSLG CD8A CD4 CCR6
48 chronic conjunctivitis 29.1 IL4 IL13 IL10 ICOSLG CD4 CCR6
49 myeloma, multiple 29.1 IL4 IL10 ICOSLG CD8A CD4 CCR6
50 leukemia, chronic lymphocytic 29.1 IL4 IL10 ICOSLG CD8A CD4 CCR6

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to Dacryoadenitis

Symptoms & Phenotypes for Dacryoadenitis

MGI Mouse Phenotypes related to Dacryoadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 CCR6 CD4 CD8A CTSS FOXP3 IL10
2 endocrine/exocrine gland MP:0005379 10.02 AQP5 CD4 CD8A CTSS FOXP3 IL10
3 digestive/alimentary MP:0005381 10.01 AQP5 CD4 CTSS FOXP3 IL10 IL13
4 immune system MP:0005387 10 CCR6 CD4 CD8A CTSS FOXP3 IL10
5 no phenotypic analysis MP:0003012 9.76 AQP5 CD4 FOXP3 IL10 IL13 IL17A
6 normal MP:0002873 9.61 CCR6 CD4 CD8A FOXP3 IL10 IL21
7 respiratory system MP:0005388 9.23 AQP5 CTSS FOXP3 IL10 IL13 IL17A

Drugs & Therapeutics for Dacryoadenitis

Drugs for Dacryoadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4
2 Proxymetacaine Phase 4
3 Anesthetics, Local Phase 4
4 Anesthetics Phase 4
5 Pharmaceutical Solutions Phase 4
6 Antibiotics, Antitubercular
7 Anti-Infective Agents
8 Anti-Bacterial Agents
9 Mitomycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort Recruiting NCT04229771 Phase 4 Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
2 The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis Unknown status NCT03216642
3 The Microbiological Spectrum in Acute Dacryocystitis Completed NCT00349297
4 Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis Completed NCT01772277
5 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
6 Evaluation and Treatment of Corneal and External Diseases and Anterior Segment Disorders Completed NCT00008541

Search NIH Clinical Center for Dacryoadenitis

Cochrane evidence based reviews: dacryocystitis

Genetic Tests for Dacryoadenitis

Anatomical Context for Dacryoadenitis

MalaCards organs/tissues related to Dacryoadenitis:

40
Eye, T Cells, Lymph Node, Salivary Gland, Skin, Bone Marrow, Thyroid

Publications for Dacryoadenitis

Articles related to Dacryoadenitis:

(show top 50) (show all 1601)
# Title Authors PMID Year
1
Lacrimal Fossa Bony Changes in Chronic Primary Acquired Nasolacrimal Duct Obstruction and Acute Dacryocystitis. 61
33583297 2021
2
The effectiveness of the dacryocystorhinostomy operation with physiodispenser in nasolacrimal duct obstruction. 61
33550897 2021
3
Acute dacryocystitis in pediatric patients and frequency of nasolacrimal duct patency. 61
31994430 2021
4
Sarcoid-like granulomatous orbitopathy-presentation, systemic involvement and clinical outcome. 61
32317795 2021
5
An Unusual Case of Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type Masquerading as Dacryocystitis and Sinusitis. 61
33559497 2021
6
Extension of Masses Involving the Lacrimal Sac to Above the Medial Canthal Tendon. 61
33587424 2021
7
Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis. 61
33491522 2021
8
IgG4-related Dacryoadenitis and Sialadenitis with Palatal Gland Swelling. 61
33583876 2021
9
Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells. 61
33562815 2021
10
Filamentous Fungus Dacryolith as a Cause of Chronic Dacryocystitis. 61
33607686 2021
11
Microbial spectrum and antibiotic sensitivity in infantile dacryocystitis. 61
33417095 2021
12
Bacterial agents and changes in drug susceptibilities in cases of chronic dacryocystitis, Southern China. 61
32813193 2021
13
Preliminary experience with exoscope in lacrimal surgery. 61
32989494 2021
14
Self-Cross-Linked Hyaluronic Acid Hydrogel in Endonasal Endoscopic Dacryocystorhinostomy: A Randomized, Controlled Trial. 61
33427772 2021
15
Orbital Microscopic Polyangiitis With Secondary Angle Closure Due to Uveal Effusion. 61
32433349 2021
16
Necrotizing Granulomatous Dacryoadenitis With Non-Necrotizing Granulomatous Scar Hypertrophy: Two Histological Variants of Sarcoidosis in the Same Patient. 61
32433350 2021
17
[Secondary eyelid pockets: Pitfalls in blepharoplasty surgery]. 61
33516573 2021
18
Acute dacryoadenitis in a patient with SARS-CoV-2 infection. 61
33402004 2021
19
Anatomical and functional outcomes of transcanalicular diode laser assisted dacryocystorhinostomy as a primary procedure. 61
33494970 2021
20
The microbiologic spectrum of dacryocystitis. 61
33430825 2021
21
Two cases of epidemic keratoconjunctivitis-associated dacryocystitis. 61
31852315 2020
22
Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren's Syndrome. 61
33356170 2020
23
Presentation, Diagnostic Evaluation, Management, and Rates of Serious Bacterial Infection in Infants With Acute Dacryocystitis Presenting to the Emergency Department. 61
32773666 2020
24
Dacryoendoscopy for dacryocystitis management in a dog: A case report. 61
33326707 2020
25
Evaluation of ostium size following endoscopic dacryocystorhinostomy as a predictive factor of outcome: A prospective study. 61
33388192 2020
26
Are systemic antibiotics required during and after dacryocystitis-related dacryocystorhinostomy? 61
31856629 2020
27
Neuroendocrine carcinoma of the nasal cavity with epiphora as the first symptom: A case report. 61
33285758 2020
28
Panophthalmitis and Visual Loss as a Complication of Acute Dacryocystitis. 61
32332690 2020
29
Dacryocystitis secondary to neglected silicone tube in lacrimal duct for 10 years: A case report. 61
33157970 2020
30
Arginase 1 is involved in lacrimal hyposecretion in male NOD mice, a model of Sjögren's syndrome, regardless of dacryoadenitis status. 61
32780506 2020
31
[Lacrimal Duct Obstruction in Adults]. 61
33207380 2020
32
Color Doppler Imaging Features of the Lacrimal Sac in Health and Diseased States. 61
32886568 2020
33
Atypical Cogan Syndrome Featuring Orbital Myositis and Dacryoadenitis. 61
32991499 2020
34
Shifting to very early endoscopic DCR in acute suppurative dacryocystitis. 61
31822856 2020
35
Aspiration Pneumonia After External Dacryocystorhinostomy Under Local Anesthesia Without Sedation: A Case Report. 61
32991495 2020
36
Re: "Panophthalmitis and Visual Loss as a Complication of Acute Dacryocystitis". 61
32925670 2020
37
Reply re: "Panophthalmitis and Visual Loss as a Complication of Acute Dacryocystitis". 61
32925671 2020
38
Infection After Endoscopic Dacryocystorhinostomy: Incidence and Implications. 61
32938219 2020
39
[The correlation between nasal bacterial microbiome diversity and surgical prognosis for chronic sinusitis with nasal polyp]. 61
33040503 2020
40
Complete resolution of a large squamous cell carcinoma of the lacrimal duct in a young African American male after non-surgical management. 61
32775768 2020
41
Complex Fistula Formations After Orbital Fracture Repair With Teflon: A Review of 3 Case Reports. 61
32881751 2020
42
Congenital lacrimal sac diverticulum. 61
32621986 2020
43
Acute dacryocystitis retention syndrome due to Epstein-Barr virus. 61
32868082 2020
44
Immunoglobulin G4 (IgG4)-Related Sialadenitis and Dacryoadenitis With Chronic Rhinosinusitis. 61
32821631 2020
45
External dacryocystorhinostomy in patients with granulomatous polyangiitis. 61
31685972 2020
46
Droopy eyelid due to IgG4-related dacryoadenitis. 61
32788315 2020
47
Effects of nitrogen dioxide exposure on the risk of eye and adnexa diseases among children in Shenzhen, China: an assessment using the generalized additive modeling approach. 61
32746628 2020
48
Lymphoproliferative tumors involving the lacrimal drainage system: a major review. 61
31267826 2020
49
Spectrum of Orbital Cellulitis on Magnetic Resonance Imaging. 61
32923259 2020
50
Nasolacrimal Duct Obstruction: An Unusual Presentation of Sarcoidosis. 61
32865461 2020

Variations for Dacryoadenitis

Expression for Dacryoadenitis

Search GEO for disease gene expression data for Dacryoadenitis.

Pathways for Dacryoadenitis

Pathways related to Dacryoadenitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 SPTAN1 RAB3D PRTN3 IL4 IL17A IL13
2
Show member pathways
13.28 IL4 IL21 IL17A IL13 IL10 CD4
3
Show member pathways
13.22 SPTAN1 PRTN3 IL4 IL17A IL13 IL10
4
Show member pathways
13.16 IL4 IL21 IL17A IL13 IL10 CD4
5
Show member pathways
12.48 IL4 IL17A IL10 CD8A CD4
6 12.44 IL4 IL17A IL10 FOXP3 CD8A
7
Show member pathways
12.4 IL4 IL21 IL17A IL13 IL10 FOXP3
8
Show member pathways
12.4 IL4 IL21 IL17A IL13 IL10 ICOSLG
9
Show member pathways
12.3 IL4 IL21 IL13 IL10
10
Show member pathways
12.21 PRTN3 CD4 CCR6 BPIFA2
11
Show member pathways
11.86 IL4 CD8A CD4
12 11.86 IL4 IL10 CD8A CD4
13 11.84 IL4 IL17A IL13 IL10
14 11.8 IL4 CD8A CD4
15
Show member pathways
11.77 IL21 IL17A FOXP3
16
Show member pathways
11.69 IL4 IL21 IL17A CD4
17
Show member pathways
11.66 IL17A IL10 CD4
18 11.64 IL10 CD8A CD4
19 11.45 IL4 IL21 IL10 ICOSLG FOXP3 CCR6
20 11.42 IL4 IL13 IL10
21 11.32 IL4 IL13 IL10 FOXP3 CD4
22 11.19 IL4 IL17A IL13
23 11.13 IL4 IL13 IL10 CD4
24 11.07 IL4 IL17A IL13 IL10 CD8A CD4
25 11.05 IL4 IL13 IL10
26 10.91 IL4 IL21 IL17A IL13 IL10
27 10.7 IL4 IL13

GO Terms for Dacryoadenitis

Cellular components related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 PRTN3 LACRT IL4 IL21 IL17A IL13
2 external side of plasma membrane GO:0009897 9.43 IL17A IL13 ICOSLG CD8A CD4 CCR6
3 extracellular region GO:0005576 9.36 SPTAN1 PRTN3 LACRT IL4 IL21 IL17A

Biological processes related to Dacryoadenitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.91 IL17A ICOSLG CTSS CD8A CD4
2 negative regulation of tumor necrosis factor production GO:0032720 9.71 IL4 IL10 FOXP3
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 IL4 IL21 IL13
4 positive regulation of T cell proliferation GO:0042102 9.67 IL4 IL21 CD4
5 positive regulation of B cell proliferation GO:0030890 9.63 IL4 IL21 IL13
6 cytokine-mediated signaling pathway GO:0019221 9.63 PRTN3 IL4 IL17A IL13 IL10 CD4
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 IL4 IL13 IL10
8 positive regulation of calcium-mediated signaling GO:0050850 9.59 LACRT CD4
9 macrophage activation GO:0042116 9.58 IL4 IL13
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10
11 T cell mediated immunity GO:0002456 9.57 FOXP3 CD8A
12 negative regulation of T-helper 17 cell differentiation GO:2000320 9.56 IL4 FOXP3
13 negative regulation of inflammatory response GO:0050728 9.56 IL4 IL13 IL10 FOXP3
14 positive regulation of mast cell degranulation GO:0043306 9.55 IL4 IL13
15 type 2 immune response GO:0042092 9.48 IL4 IL10
16 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL4 IL13
17 regulation of isotype switching GO:0045191 9.37 IL4 IL10
18 T cell activation GO:0042110 9.35 IL4 ICOSLG FOXP3 CD8A CD4
19 negative regulation of chronic inflammatory response GO:0002677 9.32 IL4 FOXP3
20 immune response GO:0006955 9.28 IL4 IL21 IL17A IL13 IL10 CTSS

Molecular functions related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.13 IL4 IL21 IL13
2 cytokine activity GO:0005125 9.02 IL4 IL21 IL17A IL13 IL10

Sources for Dacryoadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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