Aliases & Classifications for Dacryoadenitis

MalaCards integrated aliases for Dacryoadenitis:

Name: Dacryoadenitis 12 55 15 72 33
Dacryocystitis 44 72

Classifications:



External Ids:

Disease Ontology 12 DOID:950
ICD9CM 35 375.0 375.00
MeSH 44 D003607
NCIt 50 C26971
SNOMED-CT 68 86927009
ICD10 33 H04.0 H04.00
UMLS 72 C0010930 C0155223

Summaries for Dacryoadenitis

MalaCards based summary : Dacryoadenitis, also known as dacryocystitis, is related to mikulicz disease and sialadenitis. An important gene associated with Dacryoadenitis is IL21 (Interleukin 21), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotype is digestive/alimentary.

Wikipedia : 75 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing... more...

Related Diseases for Dacryoadenitis

Diseases in the Dacryoadenitis family:

Chronic Dacryoadenitis Acute Dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 34.0 IL21 AQP5
2 sialadenitis 31.3 HSPG2 AQP5
3 sjogren syndrome 29.9 HSPG2 AQP5
4 osteopoikilosis and dacryocystitis 12.7
5 acute dacryocystitis 12.5
6 chronic dacryocystitis 12.5
7 acute dacryoadenitis 12.4
8 chronic dacryoadenitis 12.4
9 phlegmonous dacryocystitis 12.4
10 lacrimal duct defect 11.6
11 lacrimoauriculodentodigital syndrome 11.2
12 igg4-related disease 10.5
13 autoimmune disease 10.4
14 sarcoidosis 1 10.3
15 ptosis 10.3
16 conjunctivitis 10.3
17 dacryocystocele 10.3
18 exophthalmos 10.3
19 aplasia of lacrimal and salivary glands 10.3 HSPG2 AQP5
20 keratitis, hereditary 10.3
21 myositis 10.3
22 vasculitis 10.3
23 keratoconjunctivitis 10.3
24 haemophilus influenzae 10.3
25 stenotrophomonas maltophilia infection 10.3
26 marginal zone b-cell lymphoma 10.2
27 b-cell lymphoma 10.2
28 crohn's disease 10.2
29 lacrimal duct obstruction 10.2
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
31 eye disease 10.2
32 metal allergy 10.2 CD8A CD4
33 polyclonal hypergammaglobulinemia 10.1 CD8A CD4
34 pfeiffer syndrome 10.1
35 mycobacterium tuberculosis 1 10.1
36 granulomatosis with polyangiitis 10.1
37 autoimmune pancreatitis 10.1
38 dry eye syndrome 10.1
39 allergic conjunctivitis 10.1
40 keratoconjunctivitis sicca 10.1
41 uveitis 10.1
42 churg-strauss syndrome 10.1
43 cellulitis 10.1
44 thyroiditis 10.1
45 herpes zoster 10.1
46 acanthamoeba keratitis 10.1
47 allergic angiitis 10.1
48 anterior uveitis 10.1
49 eosinophilic granulomatosis with polyangiitis 10.1
50 herpes zoster ophthalmicus 10.1

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to Dacryoadenitis

Symptoms & Phenotypes for Dacryoadenitis

MGI Mouse Phenotypes related to Dacryoadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 AQP5 CD4 CLCN2 HSPG2 TGFB1

Drugs & Therapeutics for Dacryoadenitis

Drugs for Dacryoadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 4 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Ophthalmic Solutions Phase 4
6 Cytochrome P-450 Enzyme Inhibitors Phase 4
7 Renal Agents Phase 4
8 Topoisomerase Inhibitors Phase 4
9 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
10 Anti-Infective Agents, Urinary Phase 4
11 Anti-Infective Agents Phase 4
12
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
13
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
14
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
15
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
16
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
18
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
19
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
20
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
21 Immunologic Factors Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Gastrointestinal Agents Phase 3
24 Antiemetics Phase 3
25 Triamcinolone hexacetonide Phase 3
26 triamcinolone acetonide Phase 3
27 Neuroprotective Agents Phase 3
28 glucocorticoids Phase 3
29 Hormones Phase 3
30 Peripheral Nervous System Agents Phase 3
31 Triamcinolone diacetate Phase 3
32 Methylprednisolone Acetate Phase 3
33 Protective Agents Phase 3
34 Immunosuppressive Agents Phase 3
35 Antineoplastic Agents, Hormonal Phase 3
36 Hormone Antagonists Phase 3
37 Betamethasone Valerate Phase 3 2152-44-5
38 Betamethasone sodium phosphate Phase 3
39 Calcium, Dietary Phase 3
40 Autonomic Agents Phase 3
41 Betamethasone-17,21-dipropionate Phase 3
42 Calcium Supplement Phase 3
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
44 Betamethasone benzoate Phase 3
45 Prednisolone acetate Phase 3
46
rituximab Approved Phase 1 174722-31-7 10201696
47
Lenalidomide Approved Phase 1 191732-72-6 216326
48 Angiogenesis Inhibitors Phase 1
49 Angiogenesis Modulating Agents Phase 1
50 Antineoplastic Agents, Immunological Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
2 Intraorbital Injection Versus Oral Steroid in Patients With Anterior Idiopathic Orbital Inflammation: A Randomized Clinical Trial Not yet recruiting NCT03958344 Phase 3 Prednisolone;Triamcinolone + Betamethason
3 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
4 The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis Unknown status NCT03216642
5 The Microbiological Spectrum in Acute Dacryocystitis Completed NCT00349297
6 Evaluation and Treatment of Corneal and External Diseases and Anterior Segment Disorders Completed NCT00008541
7 Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis Completed NCT01772277
8 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
9 Multicenter Study About Fusarium Keratitits in Spain 2012 to 2014 Completed NCT02984904
10 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
11 Lacrimal Drainage Resistance Study Completed NCT01766232
12 Comparison of Endonasal-Endoscopic Dacryocystorhinostomy Versus External Dacryocystorhinostomy Recruiting NCT02993770
13 Endoscopy Assisted Probing Versus Simple Probing in Patients With Primary Congenital Nasolacrimal Duct Obstruction: A Randomized Clinical Trial Active, not recruiting NCT03242681
14 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Not yet recruiting NCT03705000

Search NIH Clinical Center for Dacryoadenitis

Cochrane evidence based reviews: dacryocystitis

Genetic Tests for Dacryoadenitis

Anatomical Context for Dacryoadenitis

MalaCards organs/tissues related to Dacryoadenitis:

41
Eye, T Cells, Bone, Salivary Gland, Thyroid, B Cells, Skin

Publications for Dacryoadenitis

Articles related to Dacryoadenitis:

(show top 50) (show all 1489)
# Title Authors PMID Year
1
Paediatric orbital and periorbital infections. 38
31261188 2019
2
Dermoid cyst simulating recurrent dacryocystitis in a toddler. 38
31358169 2019
3
Unusual case of unilateral dacryoadenitis as a presenting feature of hypocomplementaemic urticarial vasculitis syndrome. 38
31373156 2019
4
Light chain amyloidosis of the lacrimal glands in a patient with chronic dacryoadenitis. 38
31358155 2019
5
Molecular Targeting of Immunosuppressants Using a Bi-functional Elastin-Like Polypeptide. 38
31408605 2019
6
Primary tubercular dacryocystitis - a case report and review of 18 cases from the literature. 38
30142013 2019
7
Dacryocystosclerotherapy as an alternative to dacryocystectomy. 38
30424707 2019
8
SLE dacryoadenitis. 38
30541377 2019
9
Conservative management of congenital dacryocystocele: resolution and complications. 38
31358138 2019
10
Awake bedside nasal endoscopy for primary management of neonatal dacryocystoceles with intranasal cysts. 38
31085463 2019
11
Lymphoproliferative tumors involving the lacrimal drainage system: a major review. 38
31267826 2019
12
Clinicopathologic features of biopsied lacrimal gland masses in 95 Korean patients. 38
31025214 2019
13
Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis: a review. 38
30686634 2019
14
Lacrimal Sac Sebaceous Carcinoma. 38
30921057 2019
15
Dacryoadenitis Caused by Blastomycosis: A Case Report. 38
31365512 2019
16
Congenital Dacryocystocele: A Major Review. 38
30601463 2019
17
External dacryocystorhinostomy conventional surgery versus Pawar implant: A comparative study. 38
31238430 2019
18
The Role of Bacterial Etiology in the Tear Duct Infections Secondary to Congenital Nasolacrimal Duct Obstructions. 38
31369500 2019
19
[Pediatric acute dacryocystitis due to frontoethmoidal mucocele]. 38
31065761 2019
20
Concurrent acute retinal necrosis and orbital inflammation: Report of 2 cases. 38
30854495 2019
21
A Rare Complication of Oropharyngeal Tularemia: Dacryocystitis 38
31245979 2019
22
A Rare Cause for Recurrent Implant-Related Inflammation of Orbit: Dacryocystitis. 38
30550443 2019
23
A Review of Diagnostic and Therapeutic Dacryoendoscopy. 38
31162301 2019
24
Outcome of External Dacryocystorhinostomy and Monocanalicular Intubation in Patients with Total Obstruction of One Canalicus. 38
30977323 2019
25
Chronic dacryocystitis caused by sarcoidosis. 38
30558969 2019
26
Clinical significance of ocular manifestations in granulomatosis with polyangiitis: association with sinonasal involvement and damage. 38
30706192 2019
27
Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients. 38
30701685 2019
28
The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria. 38
30696319 2019
29
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. 38
29656682 2019
30
Surfactant proteins: Role in lacrimal drainage disorders. 38
30798912 2019
31
Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lacrimal drainage system in two pediatric patients. 38
30862184 2019
32
Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature. 38
27442799 2019
33
Efficacy of nasal endoscopic dacryocystorhinostomy for chronic dacryocystitis: A systematic review protocol of randomized controlled trial. 38
30896635 2019
34
Ultrasonography-guided removal of plant-based foreign bodies from the lacrimal sac in four dogs. 38
30836969 2019
35
Dacryoadenitis due to gonococcal conjunctivitis complicated by corneal perforation. 38
29565715 2019
36
The microbiologic profile of dacryocystitis. 38
29750587 2019
37
Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease. 38
30488266 2019
38
Post-traumatic endophthalmitis caused by Nocardia nova. 38
30886723 2019
39
A Rare Case of IgG4-Related Disease Presenting as a Unilateral Severe Dacryoadenitis Complicated by Hypophysitis and Hypertrophic Pachymeningitis. 38
30724757 2019
40
Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy. 38
30709411 2019
41
Impact of sclerosing dacryoadenitis/sialadenitis on relapse during steroid therapy in patients with type 1 autoimmune pancreatitis. 38
30915865 2019
42
Dacryocystitis and Rhinosinusitis Secondary to Sarcoidosis. 38
30444768 2019
43
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. 38
30134390 2019
44
Ocular Surface Disease of Rabbits. 38
30454757 2019
45
Nasolacrimal Sac Diverticulum: A Case Series and Literature Review. 38
29952932 2019
46
IgG4-related dacryocystitis and aortitis: A new association. 38
30642193 2019
47
High Prevalence of Biofilm-Forming MRSA in the Conjunctival Flora in Chronic Dacryocystitis. 38
30794029 2019
48
Comparative study of the clinical profile of chronic dacryocystitis and chronic rhinosinusitis after external dacryocystorhinostomy. 38
31409965 2019
49
Cultures of Proximal and Distal Segments of Silicone Tubes After Dacryocystorhinostomy. 38
29927881 2019
50
A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome. 38
30359668 2018

Variations for Dacryoadenitis

Expression for Dacryoadenitis

Search GEO for disease gene expression data for Dacryoadenitis.

Pathways for Dacryoadenitis

GO Terms for Dacryoadenitis

Cellular components related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.76 VIL1 TGFB1 HSPG2 CTSZ CLCN2 CD8A
2 collagen-containing extracellular matrix GO:0062023 9.43 TGFB1 HSPG2 CTSZ
3 T cell receptor complex GO:0042101 8.96 CD8A CD4
4 microvillus GO:0005902 8.8 VIL1 TGFB1 AQP5

Biological processes related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.4 IL21 CD4
2 epidermal growth factor receptor signaling pathway GO:0007173 9.37 VIL1 TGFB1
3 T cell differentiation GO:0030217 9.32 TGFB1 CD4
4 response to vitamin D GO:0033280 9.26 TGFB1 CD4
5 positive regulation of interleukin-17 production GO:0032740 9.16 TGFB1 IL21
6 response to cholesterol GO:0070723 8.96 TGFB1 PMVK
7 T cell activation GO:0042110 8.8 TGFB1 CD8A CD4

Molecular functions related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Dacryoadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....