MCID: DCR003
MIFTS: 45

Dacryoadenitis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Dacryoadenitis

MalaCards integrated aliases for Dacryoadenitis:

Name: Dacryoadenitis 12 54 15 71 32
Dacryocystitis 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:950
ICD9CM 34 375.0
MeSH 43 D003607
NCIt 49 C26971
SNOMED-CT 67 86927009
ICD10 32 H04.0
UMLS 71 C0010930 C0155223

Summaries for Dacryoadenitis

MalaCards based summary : Dacryoadenitis, also known as dacryocystitis, is related to mikulicz disease and igg4-related disease. An important gene associated with Dacryoadenitis is IL21 (Interleukin 21), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing... more...

Related Diseases for Dacryoadenitis

Diseases in the Dacryoadenitis family:

Chronic Dacryoadenitis Acute Dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 557)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 32.3 KNTC1 IL4 IL21 IL13 IL10 CD4
2 igg4-related disease 30.5 KNTC1 IL4 ICOSLG CD4 CCR6
3 conjunctivitis 30.4 IL4 IL13 IL10
4 pfeiffer syndrome 30.3 CD8A CD4 CCR6
5 vaginitis 30.2 IL10 CD4 CCR6
6 dry eye syndrome 30.2 LACRT CCR6 AQP5
7 keratitis, hereditary 30.2 IL17A CD4 CCR6
8 sjogren syndrome 30.2 SPTAN1 IL10 HSPG2 AQP5
9 sialadenitis 30.1 SPTAN1 ICOSLG HSPG2 CD8A CD4 CCR6
10 sarcoidosis 1 30.1 IL13 ICOSLG CD8A CD4 CCR6
11 blepharoconjunctivitis 30.1 IL4 CD4
12 allergic conjunctivitis 30.0 IL4 IL13 IL10
13 lymphadenitis 30.0 IL10 ICOSLG CD4 CCR6
14 iridocyclitis 29.9 IL17A IL10 CD4
15 herpes zoster 29.9 IL10 ICOSLG CD8A CD4 CCR6
16 keratoconjunctivitis 29.8 IL4 IL17A IL13
17 granulomatosis with polyangiitis 29.8 IL17A ICOSLG CD4 CCR6
18 blastomycosis 29.7 IL17A CD4 CCR6
19 uveitis 29.7 IL4 IL17A IL10
20 subcutaneous mycosis 29.7 IL17A CD4 CCR6
21 autoimmune pancreatitis 29.6 SPTAN1 IL17A IL10 CD4
22 exanthem 29.5 IL10 ICOSLG CD8A CD4 CCR6
23 reactive arthritis 29.5 IL17A IL10 CCR6
24 aortitis 29.5 IL17A CD4
25 tularemia 29.5 IL17A CD8A CD4 CCR6
26 iritis 29.3 IL17A CD8A CD4 CCR6
27 trachoma 29.2 IL4 IL17A IL10
28 oral candidiasis 29.2 IL17A CD8A CD4 CCR6
29 autoimmune uveitis 29.2 IL4 IL17A IL10
30 chickenpox 29.2 IL4 IL10 CD8A CD4 CCR6
31 chlamydia 29.2 IL4 IL17A IL10
32 candidiasis 29.1 IL4 IL17A IL10 CCR6
33 crohn's disease 29.0 IL4 IL17A IL10 ICOSLG CD4 CCR6
34 brucellosis 29.0 IL4 IL17A IL13 IL10
35 mucocutaneous leishmaniasis 29.0 IL4 IL13 IL10 CD8A CD4
36 lymphoma, non-hodgkin, familial 28.9 IL4 IL10 ICOSLG CD8A CD4 CCR6
37 chronic conjunctivitis 28.9 IL4 IL13 IL10 ICOSLG CD4 CCR6
38 blepharitis 28.9 LACRT IL4 CD8A CD4 CCR6
39 leukemia, chronic lymphocytic 28.9 IL4 IL10 ICOSLG CD8A CD4 CCR6
40 leukemia, acute myeloid 28.9 IL4 IL10 ICOSLG CD8A CD4 CCR6
41 schistosomiasis 28.8 IL4 IL17A IL13 IL10
42 leishmaniasis 28.8 IL4 IL17A IL13 IL10
43 autoimmune disease 28.8 IL4 IL21 IL17A IL13 IL10 ICOSLG
44 keratoconjunctivitis sicca 28.8 SPTAN1 LACRT IL4 HSPG2 CD4 CCR6
45 rhinitis 28.8 IL4 IL17A IL13 IL10 ICOSLG
46 allergic rhinitis 28.7 IL4 IL17A IL13 IL10
47 dermatitis 28.6 IL4 IL17A IL13 IL10 CCR6
48 arthritis 28.5 IL4 IL17A IL13 IL10 CCR6
49 ulcerative colitis 28.5 IL4 IL17A IL13 IL10 CCR6
50 cellulitis 28.4 IL4 IL17A IL10 ICOSLG CD8A CD4

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to Dacryoadenitis

Symptoms & Phenotypes for Dacryoadenitis

MGI Mouse Phenotypes related to Dacryoadenitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 AQP5 CCR6 CD4 CTSS HSPG2 IL10
2 hematopoietic system MP:0005397 10.1 CCR6 CD4 CD8A CTSS HSPG2 IL10
3 digestive/alimentary MP:0005381 10.03 AQP5 CD4 CTSS HSPG2 IL10 IL13
4 mortality/aging MP:0010768 10.03 AQP5 CD4 CD8A HSPG2 IL10 IL13
5 immune system MP:0005387 10.02 CCR6 CD4 CD8A CTSS HSPG2 IL10
6 nervous system MP:0003631 9.85 CCR6 CD4 CD8A HSPG2 IL10 IL13
7 normal MP:0002873 9.56 CCR6 CD4 CD8A IL10 IL21 IL4
8 respiratory system MP:0005388 9.23 AQP5 CTSS HSPG2 IL10 IL13 IL17A

Drugs & Therapeutics for Dacryoadenitis

Drugs for Dacryoadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
2
Ofloxacin Approved Phase 4 82419-36-1 4583
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4
6 Cytochrome P-450 Enzyme Inhibitors Phase 4
7 Proxymetacaine Phase 4
8 Pharmaceutical Solutions Phase 4
9 Ophthalmic Solutions Phase 4
10 Anesthetics Phase 4
11 Anesthetics, Local Phase 4
12
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
13
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
14
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
15
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
16
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
17 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
18
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
19
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
20
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
21 Hormones Phase 3
22 Antineoplastic Agents, Hormonal Phase 3
23 Methylprednisolone Acetate Phase 3
24 Hormone Antagonists Phase 3
25 glucocorticoids Phase 3
26 Neuroprotective Agents Phase 3
27 Antiemetics Phase 3
28 Protective Agents Phase 3
29 Triamcinolone diacetate Phase 3
30 triamcinolone acetonide Phase 3
31 Gastrointestinal Agents Phase 3
32 Triamcinolone hexacetonide Phase 3
33 Calcium Supplement Phase 3
34 Anti-Inflammatory Agents Phase 3
35 Calcium, Dietary Phase 3
36
Calcium Nutraceutical Phase 3 7440-70-2 271
37
Lenalidomide Approved Phase 1 191732-72-6 216326
38
rituximab Approved Phase 1 174722-31-7 10201696
39 Angiogenesis Inhibitors Phase 1
40 Immunologic Factors Phase 1
41 Antirheumatic Agents Phase 1
42 Antineoplastic Agents, Immunological Phase 1
43 Mitomycins
44 Calamus

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
2 Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort Not yet recruiting NCT04229771 Phase 4 Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
3 Intraorbital Injection Versus Oral Steroid in Patients With Anterior Idiopathic Orbital Inflammation: A Randomized Clinical Trial Not yet recruiting NCT03958344 Phase 3 Prednisolone;Triamcinolone + Betamethason
4 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
5 The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis Unknown status NCT03216642
6 The Microbiological Spectrum in Acute Dacryocystitis Completed NCT00349297
7 Evaluation and Treatment of Corneal and External Diseases and Anterior Segment Disorders Completed NCT00008541
8 Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis Completed NCT01772277
9 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
10 Multicenter Study About Fusarium Keratitits in Spain 2012 to 2014 Completed NCT02984904
11 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
12 Lacrimal Drainage Resistance Study Completed NCT01766232
13 Comparison of Endonasal-Endoscopic Dacryocystorhinostomy Versus External Dacryocystorhinostomy Recruiting NCT02993770
14 Endoscopy Assisted Probing Versus Simple Probing in Patients With Primary Congenital Nasolacrimal Duct Obstruction: A Randomized Clinical Trial Active, not recruiting NCT03242681
15 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Not yet recruiting NCT03705000

Search NIH Clinical Center for Dacryoadenitis

Cochrane evidence based reviews: dacryocystitis

Genetic Tests for Dacryoadenitis

Anatomical Context for Dacryoadenitis

MalaCards organs/tissues related to Dacryoadenitis:

40
Eye, T Cells, Bone, B Cells, Salivary Gland, Thyroid, Skin

Publications for Dacryoadenitis

Articles related to Dacryoadenitis:

(show top 50) (show all 1545)
# Title Authors PMID Year
1
Lymphoproliferative tumors involving the lacrimal drainage system: a major review. 61
31267826 2020
2
[Painful orbital swelling in a 61-year-old female patient]. 61
32430688 2020
3
Bilateral interstitial keratitis, erythema nodosum and atrial fibrillation as presenting signs of polyarteritis nodosa. 61
32140612 2020
4
Toward a chimeric vaccine against multiple isolates of Mycobacteroides - An integrative approach. 61
32169520 2020
5
Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma. 61
32461486 2020
6
Bilateral dacryocystitis complicated by unilateral retrobulbar abscess in a five-week-old infant. 61
31509038 2020
7
Surgical Treatment of Dacryocystitis by Using a Venous Catheter. 61
32118659 2020
8
Behavior and outcomes of 70 adult lacrimal sac mucoceles. 61
32434405 2020
9
[Masquerade lacrimal duct stenosis: prevalence of lacrimal sac tumors]. 61
31520115 2020
10
[Diseases of the Lacrimal Gland]. 61
32016935 2020
11
Pediatric acute dacryocystitis due to Eikenella corrodens: A case report. 61
31982291 2020
12
Necrotizing Granulomatous Dacryoadenitis With Non-Necrotizing Granulomatous Scar Hypertrophy: Two Histological Variants of Sarcoidosis in the Same Patient. 61
32433350 2020
13
Dacryoadenitis Associated With Juvenile Idiopathic Arthritis. 61
31880684 2020
14
Orbital Microscopic Polyangiitis With Secondary Angle Closure Due to Uveal Effusion. 61
32433349 2020
15
Transcanalicular diode laser assisted dacryocystorhinostomy: A breakthrough in the treatment of acquired nasolacrimal duct obstruction. 61
32494278 2020
16
Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lacrimal drainage system in two pediatric patients. 61
30862184 2020
17
Endoscopic dacryocystorhinostomy: reasons for failure. 61
31595028 2020
18
CT and MRI findings in relapsing primary malignant melanoma of the lacrimal sac: a case report and brief literature review. 61
32408870 2020
19
Modified Endoscopic Dacryocystorhinostomy Using the Middle Uncinate Process Approach. 61
32310888 2020
20
Characterization and Management of Inflammatory Eye Disease in Patients with Hidradenitis Suppurativa. 61
32255701 2020
21
Antimetabolites as an adjunct to dacryocystorhinostomy for nasolacrimal duct obstruction. 61
32259290 2020
22
Sarcoid-like granulomatous orbitopathy-presentation, systemic involvement and clinical outcome. 61
32317795 2020
23
Panophthalmitis and Visual Loss as a Complication of Acute Dacryocystitis. 61
32332690 2020
24
Endoscopic Endonasal Dacryocystorhinostomy With a Novel Lacrimal Ostium Stent in Chronic Dacryocystitis Cases With Small Lacrimal Sac. 61
32282472 2020
25
IgG4-related dacryocystitis and aortitis: A new association. 61
30642193 2020
26
Predictive Value of Serum Angiotensin-Converting Enzyme Titers in Sarcoid-Like Dacryoadenitis. 61
31876678 2020
27
The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria. 61
30696319 2020
28
Loss of Pacer Spikes as electrocardiographic (EKG) Artifact Due to Microdebrider Use During Endoscopic Dacryocystorhinostomy. 61
31880683 2020
29
A Retrospective Study of Establishment of Association Between Deviated Nasal Septum, Sinusitis and Chronic Dacryocystitis. 61
32158659 2020
30
Infantile Endoscopic Dacryocystorhinostomy: Indications, Anatomical considerations, and Outcomes. 61
32118844 2020
31
The Use of Stents in Children with Nasolacrimal Duct Obstruction Requiring Surgical Intervention: A Systematic Review. 61
32046207 2020
32
Review of a novel disease entity, immunoglobulin G4-related disease. 61
32158675 2020
33
Orbital Lymphoma mimicking non-resolving dacryocystitis. 61
31948686 2020
34
Human umbilical cord mesenchymal stem cells alleviate ongoing autoimmune dacryoadenitis in rabbits via polarizing macrophages into an anti-inflammatory phenotype. 61
31891674 2020
35
Bacteriological pattern and their correlation with complications in culture positive cases of acute bacterial conjunctivitis in a tertiary care hospital of upper Assam: A cross sectional study. 61
32049777 2020
36
Acute dacryocystitis with giant lacrimal abscess: a case report. 61
32014022 2020
37
Characteristics of lacrimal passage diseases by 80-MHz ultrasound biomicroscopy: an observational study. 61
31823059 2020
38
An update on endoscopic mechanical and powered dacryocystorhinostomy in acute dacryocystitis and lacrimal abscess. 61
31465822 2020
39
Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model. 61
31996771 2020
40
Fibrous Dysplasia-like Lacrimal Sac Tumor Associated With Dacryocystitis. 61
31895726 2020
41
Sarcoid Orbital Myopathy: Clinical Presentation and Outcomes. 61
31593041 2020
42
Lacrimal Drainage Anomalies in CHARGE Syndrome: Case Report and Review of Literature. 61
31593046 2020
43
Acute dacryocystitis in pediatric patients and frequency of nasolacrimal duct patency. 61
31994430 2020
44
Endoscopic Evaluation of Lacrimal Mucosa With Indigo Carmine Stain. 61
31567915 2020
45
Relationship Between Lacrimal Bone Thickness and Lacrimal Sac in Chronic Dacryocystitis. 61
31469733 2020
46
Diagnosis of lacrimal punctum lesions using optical coherence tomography: a preliminary study. 61
32566500 2020
47
Two cases of epidemic keratoconjunctivitis-associated dacryocystitis. 61
31852315 2019
48
Shifting to very early endoscopic DCR in acute suppurative dacryocystitis. 61
31822856 2019
49
Steroid Therapy and Steroid Response in Autoimmune Pancreatitis. 61
31905944 2019
50
Masquerading dacryocystitis. 61
31908822 2019

Variations for Dacryoadenitis

Expression for Dacryoadenitis

Search GEO for disease gene expression data for Dacryoadenitis.

Pathways for Dacryoadenitis

Pathways related to Dacryoadenitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 SPTAN1 RAB3D IL4 IL17A IL13 IL10
2
Show member pathways
13.68 IL4 IL21 IL17A IL13 IL10 HSPG2
3
Show member pathways
13.26 IL4 IL21 IL17A IL13 IL10 CD4
4
Show member pathways
13.17 IL4 IL21 IL17A IL13 IL10 CD4
5
Show member pathways
12.46 IL4 IL17A IL10 CD8A CD4
6 12.41 IL4 IL17A IL10 CD8A
7
Show member pathways
12.35 IL4 IL21 IL17A IL13 IL10 ICOSLG
8
Show member pathways
12.34 IL4 IL21 IL17A IL13 IL10 CD4
9 11.84 IL4 IL10 CD8A CD4
10
Show member pathways
11.83 IL4 CD8A CD4
11 11.81 IL4 IL17A IL13 IL10
12 11.76 IL4 CD8A CD4
13
Show member pathways
11.73 IL21 IL17A IL10 CD4
14
Show member pathways
11.63 IL4 IL21 IL17A CD4
15 11.62 IL10 CD8A CD4
16 11.41 IL4 IL13 IL10
17 11.22 IL4 IL13 IL10 CD4
18 11.19 IL4 IL17A IL13
19 11.07 IL4 IL17A IL13 IL10 CD8A CD4
20 11.02 IL4 IL13 IL10
21 10.92 IL4 IL13 IL10 CD4
22 10.87 IL4 IL21 IL17A IL13 IL10 HSPG2
23 10.85 IL4 IL21
24 10.66 IL4 IL13

GO Terms for Dacryoadenitis

Cellular components related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 LACRT IL4 IL21 IL17A IL13 IL10
2 extracellular region GO:0005576 9.65 SPTAN1 LACRT IL4 IL21 IL17A IL13
3 external side of plasma membrane GO:0009897 9.1 IL17A IL13 ICOSLG CD8A CD4 CCR6

Biological processes related to Dacryoadenitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IL4 IL21 IL13
2 positive regulation of T cell proliferation GO:0042102 9.63 IL4 IL21 CD4
3 positive regulation of calcium-mediated signaling GO:0050850 9.56 LACRT CD4
4 macrophage activation GO:0042116 9.55 IL4 IL13
5 cytokine-mediated signaling pathway GO:0019221 9.55 IL4 IL17A IL13 IL10 CD4
6 positive regulation of interleukin-10 secretion GO:2001181 9.54 IL4 IL13
7 positive regulation of B cell proliferation GO:0030890 9.54 IL4 IL21 IL13
8 positive regulation of mast cell degranulation GO:0043306 9.52 IL4 IL13
9 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.51 IL4 IL10
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 IL4 IL13 IL10
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.49 IL4 IL10
12 type 2 immune response GO:0042092 9.43 IL4 IL10
13 regulation of isotype switching GO:0045191 9.4 IL4 IL10
14 immune response GO:0006955 9.28 IL4 IL21 IL17A IL13 IL10 CTSS
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.26 IL4 IL13
16 T cell activation GO:0042110 9.26 IL4 ICOSLG CD8A CD4

Molecular functions related to Dacryoadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.13 IL4 IL21 IL13
2 cytokine activity GO:0005125 9.02 IL4 IL21 IL17A IL13 IL10

Sources for Dacryoadenitis

3 CDC
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10 dbSNP
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17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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44 MESH via Orphanet
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48 NCI
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50 NDF-RT
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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