MCID: DCR002
MIFTS: 35

Dacryocystocele

Categories: Neuronal diseases

Aliases & Classifications for Dacryocystocele

MalaCards integrated aliases for Dacryocystocele:

Name: Dacryocystocele 12 15
Lacrimal Mucocele 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9939
ICD9CM 34 375.43
NCIt 50 C98968
SNOMED-CT 67 42758002
UMLS 70 C0155241

Summaries for Dacryocystocele

MalaCards based summary : Dacryocystocele, also known as lacrimal mucocele, is related to lacrimal duct defect and nasolacrimal duct cyst. An important gene associated with Dacryocystocele is FREM2 (FRAS1 Related Extracellular Matrix 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Phospholipase-C Pathway. The drug Mitomycins has been mentioned in the context of this disorder. Affiliated tissues include eye and smooth muscle, and related phenotypes are cellular and digestive/alimentary

Wikipedia : 73 Dacryocystocele (Dacryocystitis) or timo cyst is a benign, bluish-gray mass in the inferomedial canthus... more...

Related Diseases for Dacryocystocele

Diseases related to Dacryocystocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 lacrimal duct defect 11.2
2 nasolacrimal duct cyst 11.0
3 dacryoadenitis 10.5
4 dacryocystitis 10.5
5 laryngostenosis 10.4 FREM2 FRAS1
6 congenital symblepharon 10.4 FREM2 FRAS1
7 partial cryptophthalmia 10.4 FREM2 FRAS1
8 zygodactyly 1 10.4 FREM2 FRAS1
9 cryptophthalmos 10.4 FREM2 FRAS1
10 oculoectodermal syndrome 10.3 FREM2 FRAS1
11 acute dacryocystitis 10.3
12 cryptophthalmos, unilateral or bilateral, isolated 10.3 FREM2 FRAS1
13 clear cell acanthoma 10.3 FGFR2 FGF10
14 fgfr craniosynostosis syndromes 10.3 FGFR3 FGFR2
15 hemifacial hyperplasia 10.3 FGFR3 FGFR2
16 hobnail hemangioma 10.3 PIP PDPN
17 plagiocephaly 10.3 FGFR3 FGFR2
18 syndromic craniosynostosis 10.2 FGFR3 FGFR2
19 testicular spermatocytic seminoma 10.2 FGFR3 FGFR2
20 cellulitis 10.2
21 anus, imperforate 10.2 FREM2 FRAS1 FGF10
22 hypertelorism, microtia, facial clefting syndrome 10.2 FGFR3 FGFR2
23 renal hypodysplasia/aplasia 3 10.2 FREM2 FRAS1 FGFR3
24 luteoma 10.2 FGFR3 FGFR2
25 diaphragmatic hernia, congenital 10.2 FREM2 FRAS1 FGF10
26 vesicoureteral reflux 1 10.2 FREM2 FRAS1 FGFR2
27 achondroplasia, severe, with developmental delay and acanthosis nigricans 10.2 FGFR3 FGFR2
28 chromosomal duplication syndrome 10.2 FREM2 FRAS1 FGFR2
29 anal canal paget's disease 10.2 PIP KRT7
30 anal paget's disease 10.2 PIP KRT7
31 gastric signet ring cell adenocarcinoma 10.2 PIP KRT7
32 ceruminoma 10.2 PIP KRT7
33 malignant acrospiroma 10.2 PIP KRT7
34 oncocytic breast carcinoma 10.2 PIP KRT7
35 ceruminous adenocarcinoma 10.2 PIP KRT7
36 bartholin's gland disease 10.2 PIP KRT7
37 cutaneous mucoepidermoid carcinoma 10.2 PIP KRT7
38 bartholin's gland carcinoma 10.2 PIP KRT7
39 vulva adenocarcinoma 10.2 PIP KRT7
40 vulval paget's disease 10.2 PIP KRT7
41 eccrine adenocarcinoma 10.2 PIP KRT7
42 aplasia of lacrimal and salivary glands 10.2 FGFR2 FGF10
43 vulvar apocrine adenocarcinoma 10.2 PIP KRT7
44 apocrine adenocarcinoma 10.2 PIP KRT7
45 eyelid carcinoma 10.2 PIP KRT7
46 chronic maxillary sinusitis 10.2 PRTN3 PDPN
47 ureter transitional cell carcinoma 10.2 PDPN NCAM1
48 maxillary sinusitis 10.2 PRTN3 PDPN
49 malignant syringoma 10.1 PIP KRT7
50 anal canal adenocarcinoma 10.1 PIP KRT7

Graphical network of the top 20 diseases related to Dacryocystocele:



Diseases related to Dacryocystocele

Symptoms & Phenotypes for Dacryocystocele

MGI Mouse Phenotypes related to Dacryocystocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 FGF10 FGFR2 FGFR3 FRAS1 KRT7 NCAM1
2 digestive/alimentary MP:0005381 10.03 FGF10 FGFR2 FGFR3 FRAS1 NF1 PAX3
3 craniofacial MP:0005382 10 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
4 integument MP:0010771 9.97 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
5 hearing/vestibular/ear MP:0005377 9.88 FGF10 FGFR2 FGFR3 FREM2 NF1 PAX3
6 limbs/digits/tail MP:0005371 9.87 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
7 renal/urinary system MP:0005367 9.86 FGF10 FGFR2 FGFR3 FRAS1 FREM2 KRT7
8 respiratory system MP:0005388 9.76 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
9 skeleton MP:0005390 9.56 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
10 vision/eye MP:0005391 9.28 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NCAM1

Drugs & Therapeutics for Dacryocystocele

Drugs for Dacryocystocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitomycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Intraoperative Mitomycin C in Surgical Management of Lacrimal Sac Mucocele Completed NCT03176355
2 Adult Encysted Dacryocystocele: Prevalence Among Patients With Epiphora and Its Management Completed NCT04240938

Search NIH Clinical Center for Dacryocystocele

Genetic Tests for Dacryocystocele

Anatomical Context for Dacryocystocele

MalaCards organs/tissues related to Dacryocystocele:

40
Eye, Smooth Muscle

Publications for Dacryocystocele

Articles related to Dacryocystocele:

(show top 50) (show all 159)
# Title Authors PMID Year
1
Acute dacryocystitis in pediatric patients and frequency of nasolacrimal duct patency. 61
31994430 2021
2
Punctal agenesis and delayed-onset dacryocystocele in CHARGE syndrome. 61
33045382 2020
3
Endoscopic marsupialization of nasolacrimal duct cysts under topical anaesthesia: 5 years of a single institute experience. 61
32805492 2020
4
Congenital Dacryocystocele With a Massive Dumbbell-Shaped Intranasal Cyst: Open-Book Marsupialization and Histopathology. 61
31876647 2020
5
Immunoglobulin G4-related lacrimal sac dacryocystocele: A novel case report. 61
32642596 2020
6
Congenital dacryocystocele diagnosed by antenatal ultrasonography with spontaneous resolution. 61
32756791 2020
7
Management of a Case of Congenital Dacryocystocele. 61
32687201 2020
8
Intraorbital Acquired Dacryocystocele Presenting With a Scotoma. 61
32732538 2020
9
Bilateral dacryocystitis complicated by unilateral retrobulbar abscess in a five-week-old infant. 61
31509038 2020
10
Masquerades of Acquired Dacryocystocele. 61
32753833 2020
11
Value of routine ultrasound examination at 35-37 weeks' gestation in diagnosis of fetal abnormalities. 61
31595569 2020
12
Evaluation of fetal nasal cavity in bilateral congenital dacryocystocele: 3D reconstruction and virtual navigation by magnetic resonance imaging. 61
31614033 2020
13
Awake bedside nasal endoscopy for primary management of neonatal dacryocystoceles with intranasal cysts. 61
31085463 2019
14
Conservative management of congenital dacryocystocele: resolution and complications. 61
31358138 2019
15
Congenital Dacryocystocele: A Major Review. 61
30601463 2019
16
Computed tomography for guidance in the diagnosis and surgical correction of recurrent pediatric acute dacryocystitis. 61
32851287 2019
17
Selection of surgical intervention for congenital dacryocystocele. 61
29998766 2019
18
Congenital dilatation of the nasolacrimal sac (Dacryocystocele): Case report. 61
31041294 2019
19
Congenital bilateral dacryocystocele. 61
30337239 2019
20
Massive Orbital Extension of a Congenital Dacryocystocele in a 9 Month Old. 61
30134389 2019
21
Dacryoendoscopy-assisted nasal endoscopic marsupialization for congenital dacryocystocele. 61
30368393 2018
22
Ultrasonographic prenatal imaging of fetal ocular and orbital abnormalities. 61
29705173 2018
23
Endoscopic resection of a huge orbital ethmoidal mucocele masquerading as dacryocystocele. 61
30337287 2018
24
Congenital dacryocystocele: sonographic evaluation of 11 cases. 61
30227247 2018
25
Focal epilepsy as a late complication of congenital dacryocystocele. 61
30005300 2018
26
The presentation, clinical features, complications, and treatment of congenital dacryocystocele. 61
29075016 2018
27
Sacculo-cutaneous fistula after an infected dacryocystocele: treatment by nasal marsupialization and laisser faire, a case report. 61
29305169 2018
28
A Case of Lacrimal Sac Septum Presenting With Dacryocystocele. 61
28746251 2018
29
Idiopathic Acquired Dacryocystocele Presenting Only with Epiphora: A Very Rare Case Report. 61
29142801 2017
30
Congenital nasal obstruction in infants: A retrospective study and literature review. 61
28688570 2017
31
Clinical Outcome of Probing in Infants with Acute Dacryocystitis - A Prospective Study. 61
28969168 2017
32
Lacrimal Sac Smooth Muscle Tumor of Uncertain Malignant Potential. 61
27306954 2017
33
Usefulness of Ultrasonography in the Diagnosis of Neonatal Dacryocystocele. 61
28297139 2017
34
Foreign body mimicking malignancy in acquired dacryocystocele. 61
28265394 2017
35
A rare cause of intermittent respiratory distress and epiphora in the newborn: congenital dacryocystocele. 61
28210562 2017
36
Congenital dacryocystocele in infant: A rare cause of eye swelling. 61
32258581 2017
37
Congenital dacryocystocele. 61
27941115 2016
38
Dacryocystocele After Successful External Dacryocystorhinostomy: A Variant of the Lacrimal Sump Syndrome. 61
27828921 2016
39
Imaging Features of Malignant Lacrimal Sac and Nasolacrimal Duct Tumors. 61
27418476 2016
40
Orbital and Periorbital Extension of Congenital Dacryocystoceles: Suggested Mechanism and Management. 61
25186216 2016
41
[Rosenmüller valve during endoscopic dacryocystorhinostomy in treating refractory nasolacrimal duct obstruction]. 61
27480301 2016
42
Rarely Seen Nasal Congenital Problems Causing Neonatal Upper Respiratory Obstruction: A Case Series. 61
27114819 2016
43
[Congenital lacrimonasal duct cyst: Do not forget this radiological and clinical entity]. 61
26724215 2016
44
[Congenital dacryocystocele: Surgical treatment or routine follow-up?]. 61
26809596 2016
45
Prenatal detection of unilateral nasal airway obstruction caused by a dacryocystocele. 61
26223184 2016
46
Bilateral dacryocystocele with an intranasal cyst as the cause of respiratory distress in a newborn. 61
27097390 2016
47
Management of congenital dacryocystocele: report of 3 clinical cases. 61
27097399 2016
48
Bilateral Fetal Hexadactyly Combined with Transient Dacryocystocele. 61
25741667 2015
49
[Dacryocystitis in a three-week-old girl]. 61
26509540 2015
50
Congenital dacryocystoceles controlled by nCPAP via nasal mask in a neonate. 61
26016738 2015

Variations for Dacryocystocele

Expression for Dacryocystocele

Search GEO for disease gene expression data for Dacryocystocele.

Pathways for Dacryocystocele

GO Terms for Dacryocystocele

Cellular components related to Dacryocystocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.02 PRTN3 NCAM1 FRAS1 FGFR2 FGF10

Biological processes related to Dacryocystocele according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.8 PAX3 FGFR2 FGF10
2 positive regulation of MAPK cascade GO:0043410 9.78 FGFR3 FGFR2 FGF10
3 wound healing GO:0042060 9.77 NF1 FGFR2 FGF10
4 lung development GO:0030324 9.76 PDPN FGFR2 FGF10
5 fibroblast growth factor receptor signaling pathway GO:0008543 9.7 FGFR3 FGFR2 FGF10
6 regulation of smoothened signaling pathway GO:0008589 9.62 FGFR2 FGF10
7 morphogenesis of an epithelium GO:0002009 9.61 FREM2 FRAS1
8 embryonic digestive tract morphogenesis GO:0048557 9.6 FGFR2 FGF10
9 branching involved in salivary gland morphogenesis GO:0060445 9.58 FGFR2 FGF10
10 limb bud formation GO:0060174 9.57 FGFR2 FGF10
11 organ growth GO:0035265 9.56 FGFR2 FGF10
12 positive regulation of phospholipase activity GO:0010518 9.55 FGFR3 FGFR2
13 endochondral bone growth GO:0003416 9.54 FGFR3 FGFR2
14 cell communication GO:0007154 9.54 NF1 FREM2 FRAS1
15 bud elongation involved in lung branching GO:0060449 9.51 FGFR2 FGF10
16 epidermis morphogenesis GO:0048730 9.49 FGFR2 FGF10
17 lacrimal gland development GO:0032808 9.48 FGFR2 FGF10
18 otic vesicle formation GO:0030916 9.46 FGFR2 FGF10
19 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.43 FGFR2 FGF10
20 metanephros morphogenesis GO:0003338 9.4 FRAS1 FGF10
21 mesenchymal cell differentiation involved in lung development GO:0060915 9.32 FGFR2 FGF10
22 branch elongation involved in salivary gland morphogenesis GO:0060667 9.26 FGFR2 FGF10
23 mammary gland bud formation GO:0060615 9.16 FGFR2 FGF10
24 MAPK cascade GO:0000165 9.02 NF1 NCAM1 FGFR3 FGFR2 FGF10
25 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 8.96 FGFR2 FGF10

Molecular functions related to Dacryocystocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR3 FGFR2
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR3 FGFR2

Sources for Dacryocystocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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