MCID: DQR001
MIFTS: 35

De Quervain Disease

Categories: Rare diseases, Bone diseases, Muscle diseases

Aliases & Classifications for De Quervain Disease

MalaCards integrated aliases for De Quervain Disease:

Name: De Quervain Disease 12 44 15 73
Radial Styloid Tenosynovitis 12
Tenosynovitis, De Quervain's 12
De Quervains Tenosynovitis 53
De Quervain Tendinopathy 53
De Quervain's Tendinitis 53
De Quervain's Tendonitis 53
De Quervain's Syndrome 53
De Quervain's Disease 53

Classifications:



External Ids:

Disease Ontology 12 DOID:14107
ICD10 33 M65.4
ICD9CM 35 727.04
MeSH 44 D053684
UMLS 73 C0149870

Summaries for De Quervain Disease

NIH Rare Diseases : 53 De Quervain's disease is a painful wrist condition that affects the tendons on the thumb side of the wrist (the radial side). Symptoms may include pain or tenderness when moving the thumb, turning the wrist, grasping something, or making a fist. Pain may radiate to the thumb or forearm. Some people have swelling on the radial side of the wrist or difficulty holding objects. The cause of de Quervain's disease is poorly understood. Symptoms result from entrapment (compression) of the tendons in the affected area. Two tendons in the wrist and lower thumb normally glide smoothly through a tunnel connecting them to the thumb. If the area around the tendons becomes irritated, swelling may restrict their movement. The condition is often attributed to occupational or repetitive activities involving extending the thumb. It is most common among women between the ages of 30 and 50, including women who have recently had a baby or others who repetitively lift infants. It may also develop in people who have sustained direct trauma to the affected area. Treatment for de Quervain's disease may first involve splinting of the thumb and wrist, or corticosteroid injections to reduce inflammation. If injection therapy fails, surgery can relieve the entrapment.

MalaCards based summary : De Quervain Disease, also known as radial styloid tenosynovitis, is related to tenosynovitis and splenic artery aneurysm. An important gene associated with De Quervain Disease is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways is amb2 Integrin signaling. The drugs Betamethasone and Hydrocodone have been mentioned in the context of this disorder. Affiliated tissues include liver and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 De Quervain syndrome is inflammation of two tendons that control movement of the thumb and their tendon... more...

Related Diseases for De Quervain Disease

Diseases related to De Quervain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tenosynovitis 10.1
2 splenic artery aneurysm 10.0 HCK SLC4A1
3 median arcuate ligament syndrome 10.0 CAMP HCK
4 prolapse of female genital organ 9.9 HCK SLC4A1
5 plexopathy 9.8 CAMP ESR2
6 respiratory failure 9.4 ELANE SLC4A1
7 vulvitis 9.2 ELANE MRAP

Graphical network of the top 20 diseases related to De Quervain Disease:



Diseases related to De Quervain Disease

Symptoms & Phenotypes for De Quervain Disease

MGI Mouse Phenotypes related to De Quervain Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 CAMP ELANE ESR2 HCK SLC4A1
2 immune system MP:0005387 9.02 CAMP ELANE ESR2 HCK SLC4A1

Drugs & Therapeutics for De Quervain Disease

Drugs for De Quervain Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
3
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
4
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
5
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
7 Betamethasone Valerate Phase 4 2152-44-5
8 Analgesics Phase 4,Phase 3,Phase 2
9 glucocorticoids Phase 4,Phase 3
10 Respiratory System Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
12 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
13 Hormone Antagonists Phase 4,Phase 3
14 Hormones Phase 4,Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
16 Anti-Asthmatic Agents Phase 4
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
18 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
20 Antirheumatic Agents Phase 4,Phase 3,Phase 2
21 Betamethasone benzoate Phase 4
22 Betamethasone sodium phosphate Phase 4
23 Betamethasone-17,21-dipropionate Phase 4
24 Acetaminophen, hydrocodone drug combination Phase 4
25 Central Nervous System Depressants Phase 4,Phase 2
26 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
27 Narcotics Phase 4,Phase 2
28 Analgesics, Opioid Phase 4,Phase 2
29 Antipyretics Phase 4,Phase 2
30 Antitussive Agents Phase 4
31
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
32
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
33
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
34 Dexamethasone acetate Phase 3 1177-87-3
35
protease inhibitors Phase 3
36 Gastrointestinal Agents Phase 3
37 HIV Protease Inhibitors Phase 3
38 Dexamethasone 21-phosphate Phase 3
39 Antiemetics Phase 3
40 Ketorolac Tromethamine Phase 3
41 Liver Extracts Phase 3
42 BB 1101 Phase 3
43 Autonomic Agents Phase 3
44 Antineoplastic Agents, Hormonal Phase 3
45 Opiate Alkaloids Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ultrasound-guided Injection for DeQuervain's Recruiting NCT02038634 Phase 4 Betamethasone
2 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Enrolling by invitation NCT02029235 Phase 4 Acetaminophen/Hydrocodone;Acetaminophen/Ibuprofen
3 Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Recruiting NCT02266433 Phase 3 Ketorolac;Dexamethasone
4 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Not yet recruiting NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
5 Effectiveness of Astym Treatment For de Quervain's Tenosynovitis Recruiting NCT02442622 Not Applicable
6 Sinew Acupuncture for de Quervain's Tenosynovitis Recruiting NCT03472443 Not Applicable
7 Musculoskeletal Pathologies of the Upper Extremity in Surgical Device Mechanics Not yet recruiting NCT03014128

Search NIH Clinical Center for De Quervain Disease

Cochrane evidence based reviews: de quervain disease

Genetic Tests for De Quervain Disease

Anatomical Context for De Quervain Disease

MalaCards organs/tissues related to De Quervain Disease:

41
Liver, Bone

Publications for De Quervain Disease

Articles related to De Quervain Disease:

(show all 18)
# Title Authors Year
1
Ultrasound-guided methotrexate injection for De Quervain disease of the wrist: what lies beyond the horizon? ( 29026332 )
2017
2
Effectiveness of Conservative, Surgical, and Postsurgical Interventions for Trigger Finger, Dupuytren Disease, and De Quervain Disease: AA Systematic Review. ( 28860097 )
2017
3
Snapping Thumb and Superficial Radial Nerve Entrapment in De Quervain Disease: Ultrasound Imaging/Guidance Revisited. ( 26218266 )
2015
4
Ultrasound imaging for precise diagnosis and injection of isolated extensor pollicis brevis tenosynovitis: it is not always a simple de Quervain disease. ( 25415401 )
2015
5
Pulley Reconstruction As Part of the Surgical Treatment for de Quervain Disease: Surgical Technique with Medium-Term Results. ( 26261747 )
2015
6
Inflammation is present in de quervain disease-correlation study between biochemical and histopathological evaluation. ( 25650747 )
2015
7
Consensus on a multidisciplinary treatment guideline for de Quervain disease: results from the European HANDGUIDE study. ( 24700135 )
2014
8
de Quervain disease: US identification of anatomic variations in the first extensor compartment with an emphasis on subcompartmentalization. ( 21613443 )
2011
9
De Quervain disease caused by abductor pollicis longus tenosynovitis: a report of three cases. ( 19598322 )
2009
10
De quervain disease: Ibri technique to avoid superficial radial nerve injury. ( 19516139 )
2009
11
Extension of an excellent pilot study to a quantitative analysis of the pathophysiology of de Quervain disease associated with colonoscopy. ( 19879418 )
2009
12
Longitudinal incision in surgical release of De Quervain disease. ( 16175118 )
2005
13
De Quervain disease in volleyball players. ( 15716259 )
2005
14
Treatment of de Quervain disease with triamcinolone injection with or without nimesulide. A randomized, double-blind, placebo-controlled trial. ( 15590856 )
2004
15
de Quervain disease. ( 12239071 )
2002
16
Unusual course of the extensor pollicis longus tendon associated with tenosynovitis, presenting as de Quervain disease--a case report. ( 11028897 )
2000
17
Ultrasonographic evaluation of de Quervain disease. ( 9323674 )
1997
18
De Quervain disease. ( 12980685 )
1952

Variations for De Quervain Disease

Expression for De Quervain Disease

Search GEO for disease gene expression data for De Quervain Disease.

Pathways for De Quervain Disease

Pathways related to De Quervain Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.3 ELANE HCK

GO Terms for De Quervain Disease

Cellular components related to De Quervain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 specific granule lumen GO:0035580 8.62 CAMP ELANE

Biological processes related to De Quervain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytosis GO:0006909 9.16 ELANE HCK
2 antimicrobial humoral response GO:0019730 8.96 CAMP ELANE
3 negative regulation of growth of symbiont in host GO:0044130 8.62 CAMP ELANE

Sources for De Quervain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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