MCID: DQR001
MIFTS: 26

De Quervain Disease

Categories: Bone diseases, Muscle diseases, Rare diseases

Aliases & Classifications for De Quervain Disease

MalaCards integrated aliases for De Quervain Disease:

Name: De Quervain Disease 12 44 15 17 70
Radial Styloid Tenosynovitis 12
Tenosynovitis, De Quervain's 12
De Quervains Tenosynovitis 20
De Quervain Tendinopathy 20
De Quervain's Tendinitis 20
De Quervain's Tendonitis 20
De Quervain's Syndrome 20
De Quervain's Disease 20

Classifications:



External Ids:

Disease Ontology 12 DOID:14107
ICD9CM 34 727.04
MeSH 44 D053684
SNOMED-CT 67 202905002
ICD10 32 M65.4
UMLS 70 C0149870

Summaries for De Quervain Disease

GARD : 20 De Quervain's disease is a painful wrist condition that affects the tendons on the thumb side of the wrist (the radial side). Symptoms may include pain or tenderness when moving the thumb, turning the wrist, grasping something, or making a fist. Pain may radiate to the thumb or forearm. Some people have swelling on the radial side of the wrist or difficulty holding objects. The cause of de Quervain's disease is poorly understood. Symptoms result from entrapment (compression) of the tendons in the affected area. Two tendons in the wrist and lower thumb normally glide smoothly through a tunnel connecting them to the thumb. If the area around the tendons becomes irritated, swelling may restrict their movement. The condition is often attributed to occupational or repetitive activities involving extending the thumb. It is most common among women between the ages of 30 and 50, including women who have recently had a baby or others who repetitively lift infants. It may also develop in people who have sustained direct trauma to the affected area. Treatment for de Quervain's disease may first involve splinting of the thumb and wrist, or corticosteroid injections to reduce inflammation. If injection therapy fails, surgery can relieve the entrapment.

MalaCards based summary : De Quervain Disease, also known as radial styloid tenosynovitis, is related to tenosynovitis and neuritis. An important gene associated with De Quervain Disease is YIPF7 (Yip1 Domain Family Member 7). The drugs Guaifenesin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 73 De Quervain syndrome is inflammation of two tendons that control movement of the thumb and their tendon... more...

Related Diseases for De Quervain Disease

Graphical network of the top 20 diseases related to De Quervain Disease:



Diseases related to De Quervain Disease

Symptoms & Phenotypes for De Quervain Disease

Drugs & Therapeutics for De Quervain Disease

Drugs for De Quervain Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 30, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
6 Anti-Inflammatory Agents Phase 4
7 Respiratory System Agents Phase 4
8 Antirheumatic Agents Phase 4
9 Narcotics Phase 4
10 Acetaminophen, hydrocodone drug combination Phase 4
11 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
12 Analgesics Phase 4
13 Antitussive Agents Phase 4
14 Cyclooxygenase Inhibitors Phase 4
15 Analgesics, Opioid Phase 4
16 Antipyretics Phase 4
17 Analgesics, Non-Narcotic Phase 4
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
20
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
21 Anesthetics Phase 3
22 Anesthetics, Local Phase 3
23 Triamcinolone hexacetonide Phase 3
24 Triamcinolone diacetate Phase 3
25 triamcinolone acetonide Phase 3
26 Hormones Phase 3
27 Hormone Antagonists Phase 3
28 glucocorticoids Phase 3
29
Oxycodone Approved, Illicit, Investigational Phase 2 76-42-6 5284603
30 Opiate Alkaloids Phase 2

Interventional clinical trials:

(showing 8, show less)
# Name Status NCT ID Phase Drugs
1 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
2 The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study - A Single Site, Non-inferiority Randomised Control Trial Evaluating Pain After Soft Tissue Corticosteroid Injections With and Without Local Anaesthetic Suspended NCT04253457 Phase 3 1ml of triamcinolone (40mg/1ml)
3 A Randomized Trial Comparing Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Outpatient Soft Tissue Hand Surgery Completed NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
4 Sinew Acupuncture for de Quervain's Tenosynovitis: a Randomised Controlled Trial Unknown status NCT03472443
5 Effectiveness of Astym Treatment For de Quervain's Tenosynovitis Completed NCT02442622
6 Effectiveness of Neural Therapy in Patients With De Quervain Tenosynovitis Completed NCT04384536
7 Effect of Ultrasound-guided Corticosteroid Injection Versus Palpation-guided Injection for de Quervain's Disease: a Randomized Control Trial Recruiting NCT04260984
8 Treating Depression in Patients With De Quervain's Tenosynovitis; An Integrated Web Based Skills Intervention Active, not recruiting NCT04069741

Search NIH Clinical Center for De Quervain Disease

Cochrane evidence based reviews: de quervain disease

Genetic Tests for De Quervain Disease

Anatomical Context for De Quervain Disease

MalaCards organs/tissues related to De Quervain Disease:

40
Eye

Publications for De Quervain Disease

Articles related to De Quervain Disease:

(showing 55, show less)
# Title Authors PMID Year
1
De quervain tenosynovitis of the wrist. 61 20
18063716 2007
2
Physical modalities for the conservative treatment of wrist and hand's tenosynovitis: A systematic review. 61
33065423 2020
3
Effectiveness and safety of moxibustion for De Quervain disease: A protocol for systematic review and meta-analysis. 61
33285752 2020
4
Conservative Management of de Quervain Stenosing Tenosynovitis: Review and Presentation of Treatment Algorithm. 61
32590652 2020
5
Prevalence of a Septated First Dorsal Compartment Among Patients With and Without De Quervain Tenosynovitis: An In Vivo Anatomical Study. 61
30428712 2020
6
Wide Awake Local Anesthesia No Tourniquet: A Pilot Study for Carpal Tunnel Release in the Philippine Orthopedic Center. 61
31690194 2019
7
Comparison between acupotomy and local steroid injection for the management of de Quervain disease: A systematic review protocol. 61
31725617 2019
8
Impact of Septated First Dorsal Compartments on Symptomatic de Quervain Disease. 61
31348348 2019
9
Tendon Subluxation After Surgical Release of the First Dorsal Compartment in De Quervain Disease: Erratum. 61
31295171 2019
10
Tendon Subluxation After Surgical Release of the First Dorsal Compartment in De Quervain Disease. 61
31082847 2019
11
[Research progress of stenosing tenosynovitis of radial styloid process based on anatomical structure]. 61
31248247 2019
12
Factors Causing Prolonged Postoperative Symptoms Despite Absence of Complications After A1 Pulley Release for Trigger Finger. 61
30054030 2019
13
One portal endoscopic release of the first extensor compartment in de Quervain's disease. 61
30409393 2019
14
Effectiveness of Conservative, Surgical, and Postsurgical Interventions for Trigger Finger, Dupuytren Disease, and De Quervain Disease: A Systematic Review. 61
28860097 2018
15
Common Soft Tissue Musculoskeletal Pain Disorders. 61
29759125 2018
16
Sonography of Non-neoplastic Disorders of the Hand and Wrist Tendons. 61
28708327 2018
17
A novel classification of the anatomical variations of the first extensor compartment. 61
28858099 2017
18
Surgical anatomy of the first extensor compartment: A systematic review and comparison of normal cadavers vs. De Quervain syndrome patients. 61
27693273 2017
19
Ultrasound-guided methotrexate injection for De Quervain disease of the wrist: what lies beyond the horizon? 61
29026332 2017
20
Injectable Corticosteroids: Take Precautions and Use Caution. 61
28002861 2016
21
Role of Guided Ultrasound in the Treatment of De Quervain Tenosynovitis by Local Steroid Infiltration. 61
27616825 2016
22
Snapping Thumb and Superficial Radial Nerve Entrapment in De Quervain Disease: Ultrasound Imaging/Guidance Revisited. 61
26218266 2015
23
The anatomy of the fibrous and osseous components of the first extensor compartment of the wrist: a cadaveric study. 61
25645546 2015
24
The effectiveness of passive physical modalities for the management of soft tissue injuries and neuropathies of the wrist and hand: a systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) collaboration. 61
26303967 2015
25
Pulley Reconstruction As Part of the Surgical Treatment for de Quervain Disease: Surgical Technique with Medium-Term Results. 61
26261747 2015
26
Inflammation is present in de Quervain Disease--correlation study between biochemical and histopathological evaluation. 61
25650747 2015
27
Ultrasound imaging for precise diagnosis and injection of isolated extensor pollicis brevis tenosynovitis: it is not always a simple de Quervain disease. 61
25415401 2015
28
De Quervain Tenosynovitis Following Trapeziometacarpal Ball-and-Socket Joint Replacement. 61
25709877 2015
29
Consensus on a multidisciplinary treatment guideline for de Quervain disease: results from the European HANDGUIDE study. 61
24700135 2014
30
Factors associated with regional rheumatic pain disorders in a population of Puerto Ricans with diabetes mellitus. 61
24522480 2014
31
Upper limb tendinitis and entrapment neuropathy in coal miners. 61
23359408 2013
32
Clinical anatomy of the hand. 61
23219083 2012
33
Anomalous course of the extensor pollicis longus: clinical relevance. 61
21407056 2011
34
de Quervain disease: US identification of anatomic variations in the first extensor compartment with an emphasis on subcompartmentalization. 61
21613443 2011
35
De qeurvian tenosynovitis: clinical outcomes of surgical treatment with longitudinal and transverse incision. 61
22043391 2011
36
[Rheumatic disorders observed in HIV infected patients undergoing highly active antiretroviral therapy (HAART): a 366 case prospective study in Burkina Faso]. 61
22368930 2010
37
Extension of an excellent pilot study to a quantitative analysis of the pathophysiology of de Quervain disease associated with colonoscopy. 61
19879418 2009
38
De quervain disease: Ibri technique to avoid superficial radial nerve injury. 61
19516139 2009
39
Division of the first dorsal compartment of the hand into two separated canals: rule or exception? 61
19111030 2009
40
De Quervain disease caused by abductor pollicis longus tenosynovitis: a report of three cases. 61
19598322 2009
41
[The Omega "Omega" pulley plasty: a new technique for the surgical management of the De Quervain's disease]. 61
16099577 2006
42
Longitudinal incision in surgical release of De Quervain disease. 61
16175118 2005
43
Anatomical variations of the extensor pollicis brevis tendon and abductor pollicis longus tendon--relation to tenosynovectomy. 61
15934601 2005
44
De Quervain disease in volleyball players. 61
15716259 2005
45
Treatment of de Quervain disease with triamcinolone injection with or without nimesulide. A randomized, double-blind, placebo-controlled trial. 61
15590856 2004
46
de Quervain disease. 61
12239071 2002
47
Focal radial styloid abnormality as a manifestation of de Quervain tenosynovitis. 61
11717090 2001
48
Unusual course of the extensor pollicis longus tendon associated with tenosynovitis, presenting as de Quervain disease--a case report. 61
11028897 2000
49
Injection therapy for management of stenosing tenosynovitis (de Quervain's disease) of the wrist. 61
9727290 1998
50
Ultrasonographic evaluation of de Quervain disease. 61
9323674 1997
51
[Neuritis and neuroma of the sensory branches of the radial nerve. Apropos of 44 cases]. 61
1716121 1991
52
[Enlargement plasty of the radio-styloid tunnel in the treatment of De Quervain tenosynovitis]. 61
2346350 1990
53
[Use of meso-therapy with orgotein in De Quervain disease]. 61
3816118 1986
54
Anatomical variations in the first extensor compartment of the wrist. A clinical and anatomical study. 61
3733780 1986
55
De Quervain disease. 61
12980685 1952

Variations for De Quervain Disease

Expression for De Quervain Disease

Search GEO for disease gene expression data for De Quervain Disease.

Pathways for De Quervain Disease

GO Terms for De Quervain Disease

Sources for De Quervain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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