Aliases & Classifications for Deafness, Unilateral

MalaCards integrated aliases for Deafness, Unilateral:

Name: Deafness, Unilateral 56
Unilateral Deafness 6 71

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
deafness, unilateral:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 56 125000
MedGen 41 C2607947
SNOMED-CT via HPO 68 162342008 263681008
UMLS 71 C2607947

Summaries for Deafness, Unilateral

MalaCards based summary : Deafness, Unilateral, also known as unilateral deafness, is related to deafness, unilateral, with delayed endolymphatic hydrops and branchiootic syndrome 1. The drug Silver sulfadiazine has been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotype is unilateral deafness.

More information from OMIM: 125000

Related Diseases for Deafness, Unilateral

Graphical network of the top 20 diseases related to Deafness, Unilateral:



Diseases related to Deafness, Unilateral

Symptoms & Phenotypes for Deafness, Unilateral

Human phenotypes related to Deafness, Unilateral:

31
# Description HPO Frequency HPO Source Accession
1 unilateral deafness 31 HP:0009900

Symptoms via clinical synopsis from OMIM:

56
Ears:
unilateral hearing loss

Clinical features from OMIM:

125000

Drugs & Therapeutics for Deafness, Unilateral

Drugs for Deafness, Unilateral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha) in Patients With Conductive or Mixed Hearing Loss, or Unilateral Deafness Unknown status NCT01264510 Phase 4
2 Interest of the Bilateral Cochlear Implantation in the Deep Deaf Children Respect to the Unilateral Implantation - a Randomized Test Withdrawn NCT01499901 Phase 3
3 Short-term and Long-term Efficacy of the BAHA for Single Sided Deafness Completed NCT00201617
4 Subjective and Objective Benefits of a Contralateral Routing of Signals (CROS) System in Unilateral Cochlear Implant Recipients Completed NCT03078920
5 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
6 Cochlear Implantation in Cases of Single-Sided Deafness Enrolling by invitation NCT02203305
7 Unilateral Blindness/ Unilateral Deafness-relation to Neck Pain Terminated NCT00589407
8 Cochlear Implantation for Treatment of Single-sided Deafness Terminated NCT02532972

Search NIH Clinical Center for Deafness, Unilateral

Genetic Tests for Deafness, Unilateral

Anatomical Context for Deafness, Unilateral

MalaCards organs/tissues related to Deafness, Unilateral:

40
Bone, Testes, Brain, Cortex, T Cells

Publications for Deafness, Unilateral

Articles related to Deafness, Unilateral:

(show top 50) (show all 349)
# Title Authors PMID Year
1
[COCHLEAR IMPLANTS IN SINGLE-SIDED DEAFNESS]. 61
32048493 2020
2
Establishing an Animal Model of Single-Sided Deafness in Chinchilla lanigera. 61
31570054 2019
3
Off-label application of intravenous immunoglobulin (IVIG) for treatment of Cogan's syndrome during pregnancy. 61
31604714 2019
4
Sensorineural Hearing Loss After Adoptive Cell Immunotherapy for Melanoma Using MART-1 Specific T Cells: A Case Report and Its Pathophysiology. 61
31295198 2019
5
Current indications for cochlear implantation in adults and children. 61
31249147 2019
6
Single-sided deafness and cochlear implantation in congenital and acquired hearing loss in children. 61
30354002 2019
7
Duration of unilateral auditory deprivation is associated with reduced speech perception after cochlear implantation: A single-sided deafness study. 61
30486762 2019
8
Vestibular and balance function is often impaired in children with profound unilateral sensorineural hearing loss. 61
29655975 2019
9
Special edition on unilateral deafness and hearing loss: An introduction and overview. 61
30642608 2019
10
Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques. 61
31071008 2019
11
Neuroplastic change of cytoskeleton in inferior colliculus after auditory deafferentation. 61
29954642 2018
12
[The study of detection and etiology of unilateral deafness in children]. 61
30282170 2018
13
Fluctuating Hearing Loss in the Only Hearing Ear: Cochlear Implantation in the Contralateral Deaf Side. 61
29557301 2018
14
[Hearing rehabilitation with the cochlea implant following translabyrinthine CPA tumor removal ?] 61
28977813 2017
15
Cochlear Implantation in Children With Congenital Unilateral Deafness: A Case Series. 61
29135879 2017
16
Cochlear Implantation in Postlingual Adult Patients With Long-Term Auditory Deprivation. 61
28806334 2017
17
Bow hunter's syndrome in a patient with vertebral artery atresia, an arcuate foramen, and unilateral deafness: a case report. 61
28828133 2017
18
Contralateral routing of signals disrupts monaural level and spectral cues to sound localisation on the horizontal plane. 61
28666702 2017
19
Head Shadow and Binaural Squelch for Unilaterally Deaf Cochlear Implantees. 61
28570414 2017
20
Factors Influencing Cochlear Patency after Translabyrinthine Surgery. 61
28418275 2017
21
Spontaneous otoacoustic emission recordings during contralateral pure-tone activation of medial olivocochlear reflex. 61
28648121 2017
22
[Research progress on cochlear implantation in patients with unilateral deafness]. 61
29798428 2017
23
Unilateral deafness associated with a glossopharyngeal neurinoma. 61
27206392 2017
24
A comparison of the brainstem auditory evoked response in healthy ears of unilaterally deaf dogs and bilaterally hearing dogs. 61
27896671 2017
25
Hearing disorders in cats. 61
28245737 2017
26
The role of bone conduction hearing aids in congenital unilateral hearing loss: A systematic review. 61
28167010 2017
27
Audiovestibular Handicap and Quality of Life in Patients With Vestibular Schwannoma and "Excellent" Hearing. 61
28362961 2017
28
Prevalence and complications of MRI scans of cochlear implant patients : English version. 61
26886493 2017
29
Laterality and unilateral deafness: Patients with congenital right ear deafness do not develop atypical language dominance. 61
26522620 2016
30
Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness. 61
27457532 2016
31
Internal Auditory Canal Decompression for Hearing Maintenance in Neurofibromatosis Type 2 Patients. 61
26579965 2016
32
Hearing Instruments for Unilateral Severe-to-Profound Sensorineural Hearing Loss in Adults: A Systematic Review and Meta-Analysis. 61
27232073 2016
33
[Effect of cochlear implantation on sound localization for patients with unilateral sensorineural hearing loss]. 61
27625137 2016
34
Cochlear implantation in adults with unilateral deafness: A review of the assessment/evaluation protocols. 61
27142479 2016
35
Diverse etiologies manifesting auditory neuropathy characteristics from infants with profound hearing loss and clinical implications. 61
27260582 2016
36
Cochlear implantation in children with congenital unilateral deafness: Mid-term follow-up outcomes. 61
27256965 2016
37
Benefits to Speech Perception in Noise From the Binaural Integration of Electric and Acoustic Signals in Simulated Unilateral Deafness. 61
27116049 2016
38
Pencil beam scanning proton therapy for pediatric intracranial ependymoma. 61
26945580 2016
39
Predicting speech perception outcomes following cochlear implantation in adults with unilateral deafness or highly asymmetric hearing loss. 61
27099112 2016
40
Monaural Congenital Deafness Affects Aural Dominance and Degrades Binaural Processing. 61
26803166 2016
41
Somatic memory and gain increase as preconditions for tinnitus: Insights from congenital deafness. 61
26719143 2016
42
[Prevalence and complications of MRI scans of cochlear implant patients: German version]. 61
26879879 2016
43
Cochlear Implantation and Single-sided Deafness: A Systematic Review of the Literature. 61
26722349 2016
44
Role of bimodal stimulation for auditory-perceptual skills development in children with a unilateral cochlear implant. 61
26900251 2015
45
Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness. 61
26055149 2015
46
Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, following early- and late-onset deafness. 61
25764419 2015
47
Cochlear Implantation in Children with Congenital and Noncongenital Unilateral Deafness. 61
26134935 2015
48
Letter to the Editor RE: Cochlear Implantation in Children with Congenital and Noncongenital Unilateral Deafness: A Case Series. 61
26107140 2015
49
Enhanced intensity discrimination in the intact ear of adults with unilateral deafness. 61
26093448 2015
50
Cochlear implantation improves localization ability in patients with unilateral deafness. 61
25474416 2015

Variations for Deafness, Unilateral

ClinVar genetic disease variations for Deafness, Unilateral:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL4A5 NM_033380.3(COL4A5):c.2182G>A (p.Gly728Arg)SNV Uncertain significance 523545 rs1556414460 X:107846229-107846229 X:108602999-108602999

Expression for Deafness, Unilateral

Search GEO for disease gene expression data for Deafness, Unilateral.

Pathways for Deafness, Unilateral

GO Terms for Deafness, Unilateral

Sources for Deafness, Unilateral

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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