Deafness, Unilateral disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DFN341 MIFTS: 25	Deafness, Unilateral Categories: Ear diseases
Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Deafness, Unilateral

MalaCards integrated aliases for Deafness, Unilateral:

Name: Deafness, Unilateral ⁵⁶

Unilateral Deafness ⁶ ⁷¹

Characteristics:

OMIM:

⁵⁶

Inheritance:
autosomal dominant

HPO:

³¹

deafness, unilateral:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Anatomical: Ear diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁶ 125000

MedGen ⁴¹ C2607947

SNOMED-CT via HPO ⁶⁸ 162342008 263681008

UMLS ⁷¹ C2607947

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Summaries for Deafness, Unilateral

MalaCards based summary : Deafness, Unilateral, also known as unilateral deafness, is related to deafness, unilateral, with delayed endolymphatic hydrops and branchiootic syndrome 1. The drug Silver sulfadiazine has been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotype is unilateral deafness.

More information from OMIM: 125000

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Related Diseases for Deafness, Unilateral

Diseases related to Deafness, Unilateral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Related Disease	Score
1	deafness, unilateral, with delayed endolymphatic hydrops	12.2
2	branchiootic syndrome 1	10.4
3	sensorineural hearing loss	10.3
4	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	10.0
5	mumps	10.0
6	pathologic nystagmus	10.0
7	labyrinthitis	9.9
8	meningitis	9.9
9	sudden sensorineural hearing loss	9.9
10	burkitt lymphoma	9.7
11	multiple sclerosis	9.7
12	waardenburg syndrome, type 3	9.7
13	meniere disease	9.7
14	otitis media	9.7
15	spondylosis, cervical	9.7
16	retinitis pigmentosa	9.7
17	astigmatism	9.7
18	aphasia	9.7
19	lymphoma	9.7
20	inguinal hernia	9.7
21	fibrous dysplasia	9.7
22	neuroretinitis	9.7
23	parotitis	9.7
24	suppression amblyopia	9.7
25	amblyopia	9.7
26	pulmonary edema	9.7
27	suppurative otitis media	9.7
28	visual epilepsy	9.7
29	lymphocytic choriomeningitis	9.7
30	goiter	9.7
31	otosclerosis	9.7
32	viral labyrinthitis	9.7
33	bell's palsy	9.7
34	acoustic neuroma	9.7
35	vertebrobasilar insufficiency	9.7
36	facial paralysis	9.7
37	chronic purulent otitis media	9.7
38	neuroma	9.7
39	spondylosis	9.7
40	adenocarcinoma	9.7
41	astrocytoma	9.7
42	neurilemmoma	9.7
43	retinitis	9.7
44	mutism	9.7
45	dyslexia	9.7
46	cerebellar astrocytoma	9.7
47	herpes simplex	9.7
48	measles	9.7
49	myeloid leukemia	9.7
50	neuropathy	9.7

Graphical network of the top 20 diseases related to Deafness, Unilateral:

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Symptoms & Phenotypes for Deafness, Unilateral

Human phenotypes related to Deafness, Unilateral:

³¹

#	Description	HPO Frequency	HPO Source Accession
1	unilateral deafness ³¹		HP:0009900

Symptoms via clinical synopsis from OMIM:

⁵⁶

Ears:
unilateral hearing loss

Clinical features from OMIM:

125000

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Drugs & Therapeutics for Deafness, Unilateral

Drugs for Deafness, Unilateral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Silver sulfadiazine

Approved, Vet_approved

22199-08-2

441244

Synonyms:

(4-Amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver

22199-08-2

481181_ALDRICH

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt

4-amino-N-pyrimidin-2-ylbenzenesulfonamide

Abbott Brand of Silver Sulfadiazine

AC-19319

AC1L1KQS

AC1L9ATF

AC1L9Q6O

AC1NUR63

AC1O8LAG

AC-3535

AKOS005111099

AKOS005111434

Aldo Brand of Silver Sulfadiazine

ARONIS23842

Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt

Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex

Brandiazin

C10H9N4O2S.Ag

CHEBI:9142

CHEMBL1200766

CID11947738

CID31011

CID441244

CID452254

CID5459124

D00433

D012837

DB05245

Dermazin

Dermazine

EINECS 244-834-5

Flamazine

Flammazine

Geben

I06-0145

I06-145

LS-147839

Major Brand of Silver Sulfadiazine

medphano Brand of Silver Sulfadiazine

MLS000069662

MolPort-003-934-423

MolPort-003-986-619

MolPort-006-395-987

Monarch Brand of Silver Sulfadiazine

N(sup 1)-2-Pyrimidinylsulfanilamide monosilver(1+) salt

N1-2-Pyrimidinylsulfanilamide monosilver(1+) salt

NSC 625324

NSC625324

Par Brand 1 of Silver Sulfadiazine

Par Brand 2 of Silver Sulfadiazine

Par Brand 3 of Silver Sulfadiazine

Pharmascience Brand of Silver Sulfadiazine

Rhone Poulenc Rorer Brand of Silver Sulfadiazine

Rhone-Poulenc Rorer Brand of Silver Sulfadiazine

S0595

Sherwood Brand of Silver Sulfadiazine

Sicazine

Silbertone

Sildaflo

Silvadene

Silvadene (TN)

Silvederma

silver

silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide

silver 4-amino-N-pyrimidin-2-ylbenzenesulfonamide

silver sulfadiazinate

Silver sulfadiazinate

silver sulfadiazine

Silver sulfadiazine

Silver Sulfafdiazine

Silver sulphadiazine

silver(1+) [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide

Silver(I) sulfadiazine

Smith & Nephew Brand of Silver Sulfadiazine

SMR000059233

Solvay Brand of Silver Sulfadiazine

SSD

SSD (1% Silver Sulfadiazine Cream USP)

SSD AF

STL069502

Sulfadiazin silber

Sulfadiazin, silbersalz

Sulfadiazine silver

SULFADIAZINE SILVER

Sulfadiazine silver (JP15)

Sulfadiazine silver salt

Sulfadiazine silverSilvadene

Sulfadiazine, silver

Sulfadiazine, silver (USP)

Sulfadiazine, Silver [USAN]

Sulfafdiazine, Silver

Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosilver(1+) salt

Sulfanilamide,N1-2-pyrimidinyl-, monosilver(1+) salt

Sulfargen

Thermazene

TL8001845

UNII-W46JY43EJR

Zenith Brand of Silver Sulfadiazine

Interventional clinical trials:

#	Name	Status	NCT ID	Phase
1	The Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha) in Patients With Conductive or Mixed Hearing Loss, or Unilateral Deafness	Unknown status	NCT01264510	Phase 4
2	Interest of the Bilateral Cochlear Implantation in the Deep Deaf Children Respect to the Unilateral Implantation - a Randomized Test	Withdrawn	NCT01499901	Phase 3
3	Short-term and Long-term Efficacy of the BAHA for Single Sided Deafness	Completed	NCT00201617
4	Subjective and Objective Benefits of a Contralateral Routing of Signals (CROS) System in Unilateral Cochlear Implant Recipients	Completed	NCT03078920
5	Maintaining Cochlear Patency After VIIIth Nerve Surgery	Recruiting	NCT03261726
6	Cochlear Implantation in Cases of Single-Sided Deafness	Enrolling by invitation	NCT02203305
7	Unilateral Blindness/ Unilateral Deafness-relation to Neck Pain	Terminated	NCT00589407
8	Cochlear Implantation for Treatment of Single-sided Deafness	Terminated	NCT02532972

Search NIH Clinical Center for Deafness, Unilateral

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Genetic Tests for Deafness, Unilateral

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Anatomical Context for Deafness, Unilateral

MalaCards organs/tissues related to Deafness, Unilateral:

⁴⁰

Bone, Testes, Brain, Cortex, T Cells

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Publications for Deafness, Unilateral

Articles related to Deafness, Unilateral:

(show top 50) (show all 349)

#	Title	Authors	PMID	Year
1	[COCHLEAR IMPLANTS IN SINGLE-SIDED DEAFNESS]. ⁶¹	Sokolov M...Raveh E	32048493	2020
2	Establishing an Animal Model of Single-Sided Deafness in Chinchilla lanigera. ⁶¹	Banakis Hartl RM...Tollin DJ	31570054	2019
3	Off-label application of intravenous immunoglobulin (IVIG) for treatment of Cogan's syndrome during pregnancy. ⁶¹	Scherg F...Krieger T	31604714	2019
4	Sensorineural Hearing Loss After Adoptive Cell Immunotherapy for Melanoma Using MART-1 Specific T Cells: A Case Report and Its Pathophysiology. ⁶¹	Duinkerken CW...Zuur CL	31295198	2019
5	Current indications for cochlear implantation in adults and children. ⁶¹	Szyfter W...Gawecki W	31249147	2019
6	Single-sided deafness and cochlear implantation in congenital and acquired hearing loss in children. ⁶¹	Ramos Macias A...Ramos de Miguel A	30354002	2019
7	Duration of unilateral auditory deprivation is associated with reduced speech perception after cochlear implantation: A single-sided deafness study. ⁶¹	Cohen SM...Svirsky MA	30486762	2019
8	Vestibular and balance function is often impaired in children with profound unilateral sensorineural hearing loss. ⁶¹	Sokolov M...Cushing SL	29655975	2019
9	Special edition on unilateral deafness and hearing loss: An introduction and overview. ⁶¹	Gordon KA...Papsin BC	30642608	2019
10	Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques. ⁶¹	Jiang J...Ramos SJ	31071008	2019
11	Neuroplastic change of cytoskeleton in inferior colliculus after auditory deafferentation. ⁶¹	Han JJ...Park MH	29954642	2018
12	[The study of detection and etiology of unilateral deafness in children]. ⁶¹	Mei L...Yang J	30282170	2018
13	Fluctuating Hearing Loss in the Only Hearing Ear: Cochlear Implantation in the Contralateral Deaf Side. ⁶¹	Russo FY...Mosnier I	29557301	2018
14	[Hearing rehabilitation with the cochlea implant following translabyrinthine CPA tumor removal ?] ⁶¹	Schipper J...Klenzner T	28977813	2017
15	Cochlear Implantation in Children With Congenital Unilateral Deafness: A Case Series. ⁶¹	Beck RL...Arndt S	29135879	2017
16	Cochlear Implantation in Postlingual Adult Patients With Long-Term Auditory Deprivation. ⁶¹	Medina MDM...Cobeta I	28806334	2017
17	Bow hunter's syndrome in a patient with vertebral artery atresia, an arcuate foramen, and unilateral deafness: a case report. ⁶¹	Simpkin CT...Jorgensen ME	28828133	2017
18	Contralateral routing of signals disrupts monaural level and spectral cues to sound localisation on the horizontal plane. ⁶¹	Pedley AJ...Kitterick PT	28666702	2017
19	Head Shadow and Binaural Squelch for Unilaterally Deaf Cochlear Implantees. ⁶¹	Bernstein JGW...Rivera AL	28570414	2017
20	Factors Influencing Cochlear Patency after Translabyrinthine Surgery. ⁶¹	Rodgers B...Sargent E	28418275	2017
21	Spontaneous otoacoustic emission recordings during contralateral pure-tone activation of medial olivocochlear reflex. ⁶¹	Bulut E...Ozturk L	28648121	2017
22	[Research progress on cochlear implantation in patients with unilateral deafness]. ⁶¹	Shi Y...Li YX	29798428	2017
23	Unilateral deafness associated with a glossopharyngeal neurinoma. ⁶¹	Betances Reinoso FA...Chiesa Estomba CM	27206392	2017
24	A comparison of the brainstem auditory evoked response in healthy ears of unilaterally deaf dogs and bilaterally hearing dogs. ⁶¹	Plonek M...Wrzosek M	27896671	2017
25	Hearing disorders in cats. ⁶¹	Strain GM	28245737	2017
26	The role of bone conduction hearing aids in congenital unilateral hearing loss: A systematic review. ⁶¹	Liu CC...Yunker WK	28167010	2017
27	Audiovestibular Handicap and Quality of Life in Patients With Vestibular Schwannoma and "Excellent" Hearing. ⁶¹	Tveiten OV...Lund-Johansen M	28362961	2017
28	Prevalence and complications of MRI scans of cochlear implant patients : English version. ⁶¹	Grupe G...Todt I	26886493	2017
29	Laterality and unilateral deafness: Patients with congenital right ear deafness do not develop atypical language dominance. ⁶¹	Van der Haegen L...Brysbaert M	26522620	2016
30	Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness. ⁶¹	Park MH...Oh SH	27457532	2016
31	Internal Auditory Canal Decompression for Hearing Maintenance in Neurofibromatosis Type 2 Patients. ⁶¹	Bernardeschi D...Kalamarides M	26579965	2016
32	Hearing Instruments for Unilateral Severe-to-Profound Sensorineural Hearing Loss in Adults: A Systematic Review and Meta-Analysis. ⁶¹	Kitterick PT...Lucas L	27232073	2016
33	[Effect of cochlear implantation on sound localization for patients with unilateral sensorineural hearing loss]. ⁶¹	Liu JF...Wang NY	27625137	2016
34	Cochlear implantation in adults with unilateral deafness: A review of the assessment/evaluation protocols. ⁶¹	Tavora-Vieira D...Rajan GP	27142479	2016
35	Diverse etiologies manifesting auditory neuropathy characteristics from infants with profound hearing loss and clinical implications. ⁶¹	Kim SH...Choi BY	27260582	2016
36	Cochlear implantation in children with congenital unilateral deafness: Mid-term follow-up outcomes. ⁶¹	Tavora-Vieira D...Rajan GP	27256965	2016
37	Benefits to Speech Perception in Noise From the Binaural Integration of Electric and Acoustic Signals in Simulated Unilateral Deafness. ⁶¹	Ma N...Kitterick PT	27116049	2016
38	Pencil beam scanning proton therapy for pediatric intracranial ependymoma. ⁶¹	Ares C...Weber DC	26945580	2016
39	Predicting speech perception outcomes following cochlear implantation in adults with unilateral deafness or highly asymmetric hearing loss. ⁶¹	Kitterick PT...Lucas L	27099112	2016
40	Monaural Congenital Deafness Affects Aural Dominance and Degrades Binaural Processing. ⁶¹	Tillein J...Kral A	26803166	2016
41	Somatic memory and gain increase as preconditions for tinnitus: Insights from congenital deafness. ⁶¹	Eggermont JJ...Kral A	26719143	2016
42	[Prevalence and complications of MRI scans of cochlear implant patients: German version]. ⁶¹	Grupe G...Todt I	26879879	2016
43	Cochlear Implantation and Single-sided Deafness: A Systematic Review of the Literature. ⁶¹	Cabral Junior F...Bento RF	26722349	2016
44	Role of bimodal stimulation for auditory-perceptual skills development in children with a unilateral cochlear implant. ⁶¹	Marsella P...Resca A	26900251	2015
45	Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness. ⁶¹	Maslin MR...Munro KJ	26055149	2015
46	Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, following early- and late-onset deafness. ⁶¹	Wong C...Lomber SG	25764419	2015
47	Cochlear Implantation in Children with Congenital and Noncongenital Unilateral Deafness. ⁶¹	Tavora-Vieira D...Rajan GP	26134935	2015
48	Letter to the Editor RE: Cochlear Implantation in Children with Congenital and Noncongenital Unilateral Deafness: A Case Series. ⁶¹	Probst R	26107140	2015
49	Enhanced intensity discrimination in the intact ear of adults with unilateral deafness. ⁶¹	Maslin MR...Munro KJ	26093448	2015
50	Cochlear implantation improves localization ability in patients with unilateral deafness. ⁶¹	Tavora-Vieira D...Rajan GP	25474416	2015

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Genes for Deafness, Unilateral

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Variations for Deafness, Unilateral

ClinVar genetic disease variations for Deafness, Unilateral:

⁶ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	COL4A5	NM_033380.3(COL4A5):c.2182G>A (p.Gly728Arg)	SNV	Uncertain significance	523545	rs1556414460	X:107846229-107846229	X:108602999-108602999

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Expression for Deafness, Unilateral

Search GEO for disease gene expression data for Deafness, Unilateral.

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Pathways for Deafness, Unilateral

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GO Terms for Deafness, Unilateral

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Sources for Deafness, Unilateral

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia