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MCID: DCB001
MIFTS: 61

Decubitus Ulcer

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Decubitus Ulcer

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MalaCards integrated aliases for Decubitus Ulcer:

Name: Decubitus Ulcer 12 15 17
Pressure Ulcer 12 54 43 71
Pressure Ulcers 15 62
Pressure Sores 12 42
Decubitus Ulcer Any Site 12
Decubitus Ulcer 12
Bedsore 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8717
ICD9CM 34 707.0
MeSH 43 D003668
NCIt 49 C50706
SNOMED-CT 67 399912005 420226006
ICD10 32 L89
UMLS 71 C0011127
Sources

Summaries for Decubitus Ulcer

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MedlinePlus : 42 Pressure sores are areas of damaged skin caused by staying in one position for too long. They commonly form where your bones are close to your skin, such as your ankles, back, elbows, heels and hips. You are at risk if you are bedridden, use a wheelchair, or are unable to change your position. Pressure sores can cause serious infections, some of which are life-threatening. They can be a problem for people in nursing homes. You can prevent the sores by Keeping skin clean and dry Changing position every two hours Using pillows and products that relieve pressure Pressure sores have a variety of treatments. Advanced sores are slow to heal, so early treatment is best.

MalaCards based summary : Decubitus Ulcer, also known as pressure ulcer, is related to osteomyelitis and anemia, x-linked, with or without neutropenia and/or platelet abnormalities, and has symptoms including pruritus and exanthema. An important gene associated with Decubitus Ulcer is TTR (Transthyretin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs acetic acid and Rotigotine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.

PubMed Health : 62 About pressure ulcers: Some people inevitably spend a lot of time in a sitting or lying position. Most of them keep moving and shifting a little, consciously or subconsciously. But people who are extremely weak, paralyzed or unconscious may sit or lie motionless in the same position for a very long time. This puts them at greater risk of developing pressure ulcers (also called bedsores or pressure sores), which are open wounds caused by persistent external pressure against the skin. They can be very painful and usually take a long time to heal.

Wikipedia : 74 Pressure ulcers, also known as bedsores, are localized damage to the skin and/or underlying tissue that... more...

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Related Diseases for Decubitus Ulcer

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Diseases related to Decubitus Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 797)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 31.2 TNF IL6 IL1B
2 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 30.9 TTR CRP ALB
3 bacteriuria 30.6 NHS IL6 CRP ALB
4 marasmus 30.6 TTR INS ALB
5 fasciitis 30.5 TNF IL6 HECTD4 CRP
6 nutritional deficiency disease 30.5 TTR IL6 CRP ALB
7 protein-energy malnutrition 30.5 TTR TNF IL6 ALB
8 cellulitis 30.5 TNF IL6 IL1B CRP
9 rheumatic fever 30.4 TNF IL6 ALB
10 purpura 30.4 TNF IL6 CRP
11 angina pectoris 30.4 INS IL6 CRP
12 kwashiorkor 30.3 TTR INS CRP ALB
13 gingival overgrowth 30.3 TNF PDGFB IL6 FGF7 FGF2
14 spondylitis 30.3 TNF IL6 CRP
15 pancytopenia 30.3 TTR IL6 CRP ALB
16 bursitis 30.2 TNF IL1B HECTD4 CRP
17 neuritis 30.2 TNF IL6 IL1B
18 infective endocarditis 30.2 TNF IL6 CRP
19 aphthous stomatitis 30.2 TNF IL6 IL1B
20 cerebrovascular disease 30.1 TTR TNF INS IL6 CRP
21 endocarditis 30.1 TTR TNF IL6 CRP ALB
22 deficiency anemia 30.1 TNF INS IL6 CRP ALB
23 common cold 30.1 TNF IL6 IL1B ALB
24 septic arthritis 30.1 TNF IL6 IL1B CRP
25 necrotizing fasciitis 30.1 IL6 IL1B FN1 CRP ALB
26 toxic shock syndrome 30.0 TNF IL6 IL1B CRP
27 diarrhea 30.0 TTR TNF IL6 IL1B ALB
28 meningitis 30.0 VEGFA TNF IL6 IL1B CRP ALB
29 peripheral vascular disease 30.0 VEGFA INS IL6 CRP ALB
30 stomatitis 30.0 TNF IL6 IL1B FGF7
31 severe acute respiratory syndrome 29.9 TNF IL6 CRP
32 retinal detachment 29.9 VEGFA TNF PDGFB IL6 FGF2
33 plague 29.9 TNF IL6 IL1B ALB
34 adult respiratory distress syndrome 29.9 TNF IL6 IL1B FGF7
35 bronchopneumonia 29.9 TNF IL6 IL1B CRP ALB
36 pneumocystosis 29.9 TNF IL6 CRP ALB
37 irritant dermatitis 29.9 TNF IL6 IL1B
38 pyelonephritis 29.9 TNF IL6 IL1B CRP ALB
39 bacterial meningitis 29.9 TNF IL6 IL1B CRP ALB
40 arteriosclerosis 29.9 TTR PDGFB INS IL6 FGF2 CRP
41 dementia 29.9 TTR TNF PDGFB NGF IL1B
42 respiratory failure 29.9 TTR TNF IL6 IL1B CRP ALB
43 neuromyelitis optica 29.8 IL6 IL1B CRP
44 contact dermatitis 29.8 TNF NGF IL6 IL1B
45 spinal cord disease 29.8 TNF IL6 IL1B CRP ALB
46 hypothyroidism 29.8 VEGFA TTR TNF INS CRP ALB
47 limb ischemia 29.8 VEGFA TNF IL6 FGF2
48 pain agnosia 29.8 NGF IL6 IL1B HECTD4 ALB
49 graft-versus-host disease 29.8 TNF IL6 IL1B
50 constipation 29.8 TNF INS IL6 CRP ALB

Comorbidity relations with Decubitus Ulcer via Phenotypic Disease Network (PDN): (show top 50) (show all 104)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Conjunctivitis Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Aortic Valve Disease 1 Bacteremia 2
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Ulcer of Skin Communicating Hydrocephalus
Conjunctivitis Cystitis
Deficiency Anemia Dermatomycosis
Diabetes Mellitus, Ketosis-Prone Diabetes Mellitus, Noninsulin-Dependent
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Erythematosquamous Dermatosis Esophageal Candidiasis
Esophageal Disease Familial Atrial Fibrillation
Femoral Vein Thrombophlebitis Folic Acid Deficiency Anemia
Gas Gangrene Generalized Atherosclerosis
Heart Disease Hepatic Encephalopathy
Hydronephrosis Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Intestinal Obstruction Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia

Graphical network of the top 20 diseases related to Decubitus Ulcer:



Diseases related to Decubitus Ulcer
Sources

Symptoms & Phenotypes for Decubitus Ulcer

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UMLS symptoms related to Decubitus Ulcer:


pruritus, exanthema

MGI Mouse Phenotypes related to Decubitus Ulcer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 ALB CRP FGF2 FN1 IL1B IL6
2 homeostasis/metabolism MP:0005376 10.28 ALB CRP FGF2 FGF7 FN1 IL1B
3 hematopoietic system MP:0005397 10.23 FGF2 FGF7 FN1 IL1B IL6 INS
4 immune system MP:0005387 10.14 ALB CRP FGF7 FN1 IL1B IL6
5 integument MP:0010771 10.07 FGF7 FN1 IL1B IL6 INS NGF
6 muscle MP:0005369 10.02 ALB FGF2 FN1 IL6 INS NGF
7 neoplasm MP:0002006 9.8 ALB FGF2 FN1 IL1B IL6 TNF
8 no phenotypic analysis MP:0003012 9.7 INS NGF NHS PDGFB TNF TTR
9 renal/urinary system MP:0005367 9.56 ALB FGF7 IL6 INS PDGFB PLEKHG5
10 vision/eye MP:0005391 9.32 FGF2 FGF7 IL6 INS NGF NHS
Sources

Drugs & Therapeutics for Decubitus Ulcer

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PubMed Health treatment related to Decubitus Ulcer: 62

As much pressure as possible should be taken off of the pressure ulcer . The most important thing is to stop sitting or lying on the wound . Special positioning aids, special soft mattresses, and regular repositioning and movement help to relieve the pressure. Sterile wound dressings are usually used to protect the wound and help it to heal. If necessary, the wound is also regularly cleaned and dead tissue removed. The most appropriate treatment will depend on the type and severity of the pressure ulcer .

Drugs for Decubitus Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
acetic acid Approved Phase 4 64-19-7 176
2
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Nitric Oxide Approved Phase 4 10102-43-9 145068
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
St. John's Wort Approved, Investigational, Nutraceutical Phase 4 84082-80-4
9
Retinol acetate Phase 4 127-47-9 10245972
10 Olive Phase 4
11 Dopamine agonists Phase 4
12 Trace Elements Phase 4
13 Micronutrients Phase 4
14 Pharmaceutical Solutions Phase 4
15 Narcotics Phase 4
16 Disinfectants Phase 4
17 Nutrients Phase 4
18 Anesthetics Phase 4
19 Analgesics Phase 4
20 Hormones Phase 4
21 Excitatory Amino Acid Antagonists Phase 4
22 Anesthetics, Dissociative Phase 4
23 Anesthetics, General Phase 4
24 Neurotransmitter Agents Phase 4
25 Anesthetics, Intravenous Phase 4
26
Polihexanide Approved, Investigational Phase 3 28757-47-3
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2, Phase 3 437-38-7 3345
28
Curcumin Approved, Experimental, Investigational Phase 3 458-37-7 969516
29
Lopinavir Approved Phase 2, Phase 3 192725-17-0 92727
30
Hydroxychloroquine Approved Phase 2, Phase 3 118-42-3 3652
31
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
32
Azithromycin Approved Phase 2, Phase 3 83905-01-5 447043 55185
33
Oxandrolone Approved, Investigational Phase 3 53-39-4 5878
34
Tamsulosin Approved, Investigational Phase 3 106133-20-4 129211
35 Anti-Anxiety Agents Phase 3
36 GABA Modulators Phase 3
37 Antioxidants Phase 3
38 Omega 3 Fatty Acid Phase 3
39 Analgesics, Non-Narcotic Phase 3
40 Anti-Inflammatory Agents Phase 3
41 Anti-Inflammatory Agents, Non-Steroidal Phase 3
42 Anti-Infective Agents Phase 2, Phase 3
43 Anti-Bacterial Agents Phase 2, Phase 3
44 Antirheumatic Agents Phase 2, Phase 3
45 Antiviral Agents Phase 2, Phase 3
46
protease inhibitors Phase 2, Phase 3
47 HIV Protease Inhibitors Phase 2, Phase 3
48 Antiparasitic Agents Phase 2, Phase 3
49 Antiprotozoal Agents Phase 2, Phase 3
50 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 386)
# Name Status NCT ID Phase Drugs
1 A 12-week, Single Site, Randomized Controlled Trial to Compare the Efficacy of Quantum NPWT With and Without Simultaneous Irrigation Versus Standard of Care on Reduction of the Volume of Stage III/IV Pressure Ulcers. Unknown status NCT01734109 Phase 4
2 Olive Oil's Cream Effectiveness in Prevention of Pressure Ulcers in Immobilized Patients in Primary Care.A Cluster Randomized Clinical Trial. Unknown status NCT01595347 Phase 4 Hyper-oxigenated fatty acid
3 Post-Market Clinical Evaluation of the Spiracur SNaP Wound Care System Unknown status NCT01113658 Phase 4
4 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
5 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Unknown status NCT03098368 Phase 4 Rotigotine;Placebo
6 Negative Pressure Wound Therapy With the Engenexâ„¢-Pump and Bio-Domeâ„¢ Dressing, an Evaluation Unknown status NCT01107821 Phase 4
7 Evaluation of Wound Management for Sacral Pressure Ulcers With Necrotic Tissue Completed NCT02224638 Phase 4
8 A Six Month Randomized Open-Label Trial of Pressure Ulcer Healing With Microcyn® Skin and Wound Care With Preservatives Versus Sterile Saline in Adult Spinal Cord Injury Subjects Completed NCT02001558 Phase 4 Microcyn
9 A Multi-centre, Post CE-mark, Open Study to Evaluate the Performance of Thin Self-adherent Dressing Coated With a Soft Silicone Layer on Subjects With High Risk of Category 2 or Above Pressure Ulceration Completed NCT01438541 Phase 4
10 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation. Randomized Clinical Trial Completed NCT02526862 Phase 4
11 A Double-blind, Comparative, Superiority, Multi-centre Investigation Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers Completed NCT01036438 Phase 4
12 Determination of the 90% Effective Dose of a Sufentanil Bolus in Analgesia During Lateral Decubitus of Mechanically Ventilated Patients. Completed NCT01356732 Phase 4 Sufentanil
13 Different Radiation Exposures to Patient and Endoscopists Between Performing ERCP in Patients Lying Prone and Left Lateral Decubitus Completed NCT01599351 Phase 4
14 A Prospective, Randomized, Controlled Clinical Investigation, Comparing Trauma to Peri-Wound Skin and Pain When Using Two Different Wound Dressings Completed NCT02904200 Phase 4
15 A Prospective, Comparative, Single-centre Clinical Evaluation to Investigate the Skin-to-skin Time of the First Surgical Debridement of Lower Extremity Ulcers With VERSAJETâ„¢ Hydrosurgery System and Conventional Debridement Techniques. Completed NCT00521027 Phase 4
16 Evaluation of Provase in the Post Burn Rehabilitation Population for Itch Control and Moisturization Properties Completed NCT00782054 Phase 4
17 Effect of Prolonged Decubitus on Bronchial Inflammation in COPD Patients Evaluated by Expired NO Concentration Assessment Completed NCT01555593 Phase 4
18 Randomized Controlled Clinical Trial of 2% Chlorhexidine Gluconate-Impregnated Bath Cloths to Prevent MRSA Colonization on Complex Continuing Care Units of Baycrest Hospital Completed NCT01717690 Phase 4 CHG antiseptic body cleanser
19 A Monocentric, Comparative and Randomized Study on Pressure Ulcers Prevention With Mepilex® Border Sacrum Dressing in Scheduled Cardiovascular Surgery Recruiting NCT03823963 Phase 4
20 Interest in the Use of Dressings With Honey for Wound Healing After Excision of Pilonidal Cyst Recruiting NCT02485860 Phase 4
21 A Randomized Controlled Trial of Enzymatic Debridement of Pressure Ulcers With Clostridial Collagenase Ointment (SANTYL®) or Hydrogel (SoloSite®) Terminated NCT02718625 Phase 4
22 A 12-week, Prospective, Open-label, Randomized, Controlled Clinical Trial Comparing Negative Pressure Wound Therapy (NPWT) to Standard Wound Care for the Treatment of Chronic Pressure Wounds of the Pelvic Region Terminated NCT00691821 Phase 4
23 Honey Dressings for Local Wound Care of Split Thickness Skin Graft and Free Tissue Transfer Donor Sites: A Prospective, Randomized, Controlled Trial. Terminated NCT02259491 Phase 4
24 The Effect and Tolerance of a Ketamine Subcutaneous Bolus, During Painful Care of Refractory Bed Sores, Ulcers and Vascular Wounds in a Palliative Care Unit Terminated NCT02587130 Phase 4 Ketamine
25 A Prospective, Randomized, Controlled, Multi-Center, Study Evaluating AutoloGel Therapy for Complete Closure of Wagner Grade 1-4 Diabetic Foot Ulcers, Venous Leg Ulcers and Stage II-IV Pressure Ulcers Withdrawn NCT02248077 Phase 4
26 Clinical Outcomes for Chronic Ulcers Treated With Clostridial Collagenase (SANTYL®) Versus Standard Care Within the Continuum of Care of an Accountable Care Organization (ACO) Withdrawn NCT02716519 Phase 4
27 Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers Withdrawn NCT02689310 Phase 4
28 PEMF Effects on Pain After Abdominal Body Contouring Withdrawn NCT01762423 Phase 4
29 A Comparison of OASIS Wound Matrix With Approved Dressings for Split Thickness Skin Graft Donor Sites Withdrawn NCT02994589 Phase 4
30 Stem Cells In Wound Healing With Collagen Matrix as a Carrier Withdrawn NCT02314416 Phase 4
31 Monochromatic Phototherapy on Diabetic Foot Ulcers. A Twenty Weeks Prospective, Randomised, Double Blind, Multi-centre, Placebo Controlled Study Unknown status NCT00859599 Phase 3
32 Ketamine's Efficiency in the Treatment of Chronic Pain With an Added Inflammatory Component Exploring the Kynurenin Pathway. A Randomized, Double Blind, Placebo-controlled Trial Unknown status NCT03513822 Phase 3 Ketamine 10 MG/ML;Placebos;Midazolam 1 MG/ML
33 The Fluid Therapy Strategy of the Patients With Acute Ischemic Stroke and a Bun/Cr Ratio Less Than 15. Unknown status NCT02668848 Phase 2, Phase 3
34 Interdisciplinary Pressure Management & Mobility Program as an Alternative to Bed Rest: A Pilot Study Completed NCT00796042 Phase 3
35 Interdisciplinary Mobility Approach To Reduction Of Facility-Acquired Pressure Ulcers Completed NCT01008254 Phase 2, Phase 3
36 Lifestyle Redesign for Pressure Ulcer Prevention in Spinal Cord Injury Completed NCT01999816 Phase 3
37 Preventing Pressure Ulcers: A Multi-site RCT in Nursing Facilities Completed NCT00665535 Phase 3
38 Pressure Ulcer Multi-disciplinary Teams Via Telemedicine (PUMTT): A Cluster Pragmatic Randomised Controlled Trial in Long Term Care Completed NCT01232764 Phase 3
39 Comparison of Two Turning Regimens (2 Versus Every 4 Hours) in the Prevention of Pressure Ulcers in Patients on Mechanical Ventilation That Use Alternating-pressure Air Mattresses. Completed NCT00847665 Phase 3
40 Maggot Therapy for Wound Debridement: a Randomized Multicentric Double-blind Trial Completed NCT01211236 Phase 3
41 Efficacy of Prontosan Solution on Chronic Ulcers Completed NCT01333670 Phase 3 Isotonic solution (saline or lactated ringer)
42 Safety of Intranasal Fentanyl (PecFent®) in the Treatment of Procedural Pain in the Elderly With or Without Background Treatment. Completed NCT02298582 Phase 2, Phase 3 intranasal fentanyl
43 Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing Completed NCT01214811 Phase 3
44 Neural Consequences of Chronic Inflammation in Individuals With Spinal Cord Injury and the Influence of an Anti-inflammatory Diet Completed NCT02099890 Phase 3
45 Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide: Randomized Clinical Trial Completed NCT02394821 Phase 3 Polihexanide 2%;Metronidazole 0.8%
46 Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness Completed NCT02639481 Phase 3
47 A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Pressure Ulcers Recruiting NCT02312570 Phase 2, Phase 3
48 Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia: A Pragmatic Randomized Controlled Trial Not yet recruiting NCT04359095 Phase 2, Phase 3 Hydroxychloroquine;Lopinavir / Ritonavir Pill;Azithromycin
49 Impact of Skin Dressings Compared With Cream for Skin Lubrication in the Prevention of Pressure Ulcers in Patients at High or Very High Risk: A Multicenter Randomized Trial Terminated NCT02565745 Phase 3
50 CSP #535 - Anabolic Steroid Therapy on Pressure Ulcer Healing in Persons With Spinal Cord Injury Terminated NCT00101361 Phase 3 Oxandrolone;Placebo

Search NIH Clinical Center for Decubitus Ulcer

Cochrane evidence based reviews: pressure ulcer

Sources

Genetic Tests for Decubitus Ulcer

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Anatomical Context for Decubitus Ulcer

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MalaCards organs/tissues related to Decubitus Ulcer:

40
Skin, Spinal Cord, Bone, Testes, Colon, Brain, Skeletal Muscle
Sources

Publications for Decubitus Ulcer

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Articles related to Decubitus Ulcer:

(show top 50) (show all 4663)
# Title Authors PMID Year
1
Effect of intraoperative pressure ulcer preventive nursing on inflammatory markers in patients with high-risk pressure ulcers: A protocol of systematic review and meta-analysis. 42 61
32443363 2020
2
Update to device-related pressure ulcers: SECURE prevention. COVID-19, face masks and skin damage. 42
32421479 2020
3
Appraisal and recommendation synthesis of guidelines and consensuses for interventions of pressure ulcers: A protocol for systematic review. 42
32481344 2020
4
Assessment of a prognostic biochemical indicator of nutrition and inflammation for identification of pressure ulcer risk. 54 61
16505284 2006
5
Survey of nutritional status in newly hospitalized patients with stage III or stage IV pressure ulcers. 61 54
11075011 2000
6
Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145. 61
31905030 2020
7
Pressure Injuries in the Pediatric Population: Analysis of the 2008-2018 International Pressure Ulcer Prevalence Survey Data. 61
32427786 2020
8
Reconstruction of Sacral Pressure Ulcer Using a Modified Parasacral Perforator-Based Flap (Maple Leaf Design): An Easier Method for Beginners. 61
32524869 2020
9
Under (less) pressure - Facial pressure ulcer development in ventilated ICU patients: A prospective comparative study comparing two types of endotracheal tube fixations. 61
32029382 2020
10
Health and medical device development for fundamental care: Scoping review. 61
31512288 2020
11
The use of a mobile educational tool on pressure injury education for individuals living with spinal cord injury/disease: a qualitative research study. 61
32493089 2020
12
Relationship Between Practice and Attitude Regarding Pressure Injury Among Intensive Care Nurses in Iran: A Descriptive, Correlational Study. 61
32511102 2020
13
Repositioning for pressure injury prevention in adults. 61
32484259 2020
14
The coccygeal pressure ulcer-does coccygectomy prevent recurrence? 61
32555143 2020
15
Outcomes for Pressure Ulcer Trials (OUTPUTs) project: review and classification of outcomes reported in pressure ulcer prevention research. 61
32510579 2020
16
Complications after pressure ulcer surgery - a study of 118 operations in spinal cord injured patients. 61
32003279 2020
17
Pressure ulcers after traumatic spinal injury in East Africa: risk factors, illustrative case, and low-cost protocol for prevention and treatment. 61
32541848 2020
18
Negative Pressure Wound Therapy in Pyoderma Gangrenosum Treatment. 61
32520925 2020
19
Incidence and prevalence of pressure ulcers in cancer patients admitted to hospice: A multicentre prospective cohort study. 61
32045116 2020
20
A systematic and psychometric review of tests measuring nurses' wound care knowledge. 61
32496632 2020
21
Nurses' knowledge, attitudes, and behaviors related to pressure injury prevention: A large-scale cross-sectional survey in mainland China. 61
32497357 2020
22
Device-related pressure ulcers in community settings. 61
32501759 2020
23
Healing hand ulcers caused by focal spasticity. 61
32135027 2020
24
Comparison of platelet-rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs. 61
32212258 2020
25
Effect of preventive care interventions on pressure ulcer rates in a national sample of rural and urban nursing units: Longitudinal associations over 4 years. 61
32203754 2020
26
Factors related to knowledge, attitude, and practice of nurses in intensive care unit in the area of pressure ulcer prevention: A multicenter study. 61
32061501 2020
27
The mechanism of persistent undermining of a sacral pressure ulcer: Experimental analyses using a deformable model and examination of skin mobility over different anatomical locations. 61
32165036 2020
28
Psychometric Properties of the Chinese Version of the Pieper-Zulkowski Pressure Ulcer Knowledge Test in Nursing Practice: A Cross-sectional Survey. 61
32304453 2020
29
Impaired mobility and pressure ulcer development in older adults: Excess movement and too little movement-Two sides of the one coin? 61
32380572 2020
30
Evaluating the Impact of an Innovative Educational Program for Skin Care Champions Using the Pieper-Zulkowski Pressure Ulcer Knowledge Test. 61
32304448 2020
31
Sex-specific differences in prevention and treatment of institutional-acquired pressure ulcers in hospitals and nursing homes. 61
32471633 2020
32
Extracorporeal shockwave therapy combined with alginate dressing for treatment of sacroiliac decubital necrosis in older adults: A case report. 61
32384429 2020
33
A Multicenter Case-Historical Control Study on Short-Term Outcomes of Tele-Intensive Care Unit. 61
31436501 2020
34
Finnish and Swedish prehospital emergency care providers' knowledge and attitudes towards pressure ulcer prevention. 61
32448755 2020
35
Comparison of four pressure ulcer risk assessment tools in critically ill patients. 61
32368844 2020
36
Implementation of the best practice guideline for pressure ulcer prevention: Development, results and sustainability. 61
32418849 2020
37
Predictive Validity of the Braden Scale for Pressure Ulcer Risk in Critical Care: A Meta-Analysis. 61
31985893 2020
38
Challenges in the management of critical ill COVID-19 patients with pressure ulcer. 61
32383319 2020
39
N95 respirator associated pressure ulcer amongst COVID-19 health care workers. 61
32397010 2020
40
Risk factors affecting pressure ulcer healing: Impact of prescription medications. 61
31916373 2020
41
Pressure ulcer/injury classification today: An international perspective. 61
32414554 2020
42
Sacral Extradural Angiolipoma Associated with Tight Filum Terminale and Spina Bifida Coexisting with Spinal Arteriovenous Fistula. 61
32407913 2020
43
Characteristics and Outcomes of Dementia Patients Who Receive Inpatient Palliative Care Consultation. 61
32416004 2020
44
Factors Associated with Higher Rates of Heterotopic Ossification after Spinal Cord Injury: A Systematic Review and Meta-Analysis. 61
32388145 2020
45
Compressive Neuropathy of the Facial Nerve Presenting as Bell's Palsy in a Pediatric Patient on High-Frequency Oscillatory Ventilation. 61
32542146 2020
46
Insight Into the Movement Behaviors of Nursing Home Residents Living With Obesity: A Report of Two Cases. 61
32401731 2020
47
A Survey of Nurses' Need for Care Robots in Children's Hospitals: Combining Robot-Care, Game-Care, and Edu-Care. 61
31009402 2020
48
The microclimate under dressings applied to intact weight-bearing skin: Infrared thermography studies. 61
32335474 2020
49
Seated buttocks anatomy and its impact on biomechanical risk. 61
32008891 2020
50
Cost-effectiveness of multi-layered silicone foam dressings for prevention of sacral and heel pressure ulcers in high-risk intensive care unit patients: An economic analysis of a randomised controlled trial. 61
32391627 2020
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Variations for Decubitus Ulcer

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Expression for Decubitus Ulcer

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Search GEO for disease gene expression data for Decubitus Ulcer.
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Pathways for Decubitus Ulcer

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Pathways related to Decubitus Ulcer according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.04 VEGFA TTR TNF PDGFB OSCAR INS
2
ERK Signaling 63
Show member pathways
 13.84 VEGFA TNF PDGFB NGF IL6 IL1B
3
TGF-Beta Pathway 63
Show member pathways
 13.54 VEGFA TNF PDGFB NGF INS IL6
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.36 VEGFA TNF PDGFB IL6 IL1B FN1
5
PAK Pathway 63
Show member pathways
 13.32 TNF PDGFB NGF IL6 IL1B FGF7
6
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.26 VEGFA TNF SLC7A1 PDGFB NGF IL6
7
Phospholipase-C Pathway 63
Show member pathways
 13.08 PDGFB NGF IL6 FN1 FGF7 FGF2
8
p70S6K Signaling 63
Show member pathways
 13.07 PDGFB NGF INS IL6 FGF7 FGF2
9
Human cytomegalovirus infection 36
Show member pathways
 12.95 VEGFA TNF PDGFB IL6 IL1B FGF2
10
Allograft rejection 1 36
Show member pathways
 12.86 VEGFA TNF INS IL6 IL1B
11
Pathways in cancer 36
12.82 VEGFA PLEKHG5 PDGFB IL6 FN1 FGF7
12
PI3K-Akt signaling pathway 36
Show member pathways
 12.81 VEGFA TNF PDGFB NGF INS IL6
13
Ras signaling pathway 36
Show member pathways
 12.71 VEGFA PDGFB NGF INS FGF7 FGF2
14
NF-KappaB Family Pathway 63
Show member pathways
 12.69 TNF PDGFB NGF IL6 IL1B FGF7
15
Regulation of actin cytoskeleton 36 1
12.65 PDGFB INS FN1 FGF7 FGF2
16
MAPK signaling pathway 36 1
12.64 VEGFA TNF PDGFB NGF INS IL1B
17
Immune response IL-23 signaling pathway 22
Show member pathways
 12.59 TNF PDGFB IL6 IL1B FN1 FGF2
18
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.41 PDGFB NGF IL6 FGF7 FGF2
19
Proteoglycans in cancer 36
12.32 VEGFA TNF FN1 FGF2
20
Folate Metabolism 1
Show member pathways
 12.3 TNF INS IL6 IL1B CRP ALB
21
Bacterial infections in CF airways 22
Show member pathways
 12.21 TNF IL6 IL1B FN1
22
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.21 TNF PDGFB NGF IL6 IL1B FGF7
23
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.17 VEGFA TNF NGF IL6 IL1B
24
Fluid shear stress and atherosclerosis 36
12.11 VEGFA TNF PDGFB IL1B
25
Yersinia infection 36
12.02 TNF IL6 IL1B FN1
26
Senescence and Autophagy in Cancer 1
11.95 INS IL6 IL1B FN1
27
Amoebiasis 36
11.93 TNF IL6 IL1B FN1
28
AGE-RAGE signaling pathway in diabetic complications 36
11.91 VEGFA TNF IL6 IL1B FN1
29
Rheumatoid arthritis 36
11.87 VEGFA TNF IL6 IL1B
30
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.85 PDGFB INS IL6 FN1 FGF2
31
Neural Stem Cells and Lineage-specific Markers 64
11.78 VEGFA PDGFB NGF FGF2
32
Pertussis 36
11.77 TNF IL6 IL1B
33
Dendritic Cells Developmental Lineage Pathway 64
11.76 TNF IL6 IL1B
34
G-protein signaling_RhoA regulation pathway 22
11.75 PDGFB NGF IL6 FGF7 FGF2
35
Interleukin-4 and 13 signaling 65
11.69 VEGFA TNF IL6 IL1B FN1 FGF2
36
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.67 VEGFA TNF IL6 IL1B
37
Legionellosis 36
11.63 TNF IL6 IL1B
38
Photodynamic therapy-induced AP-1 survival signaling. 1
11.58 TNF IL6 FGF7
39
Malaria 36
11.57 TNF IL6 IL1B
40
Interleukin-10 signaling 65
11.56 TNF IL6 IL1B
41
Cell adhesion_Plasmin signaling 22
11.56 VEGFA FN1 FGF2
42
amb2 Integrin signaling 1
11.54 TNF IL6 FN1
43
Integrins in angiogenesis 1
11.52 VEGFA FN1 FGF2
44
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.51 TNF IL6 IL1B
45
FOXA2 and FOXA3 transcription factor networks 1
11.5 TTR INS ALB
46
Vemurafenib Pathway, Pharmacodynamics 60
11.47 VEGFA PDGFB FGF7 FGF2
47
African trypanosomiasis 36
11.4 TNF IL6 IL1B
48
IL-10 Pathway 63
11.37 TNF IL6 IL1B
49
Differentiation Pathway 1
11.34 VEGFA PDGFB INS IL6 FGF2
50
Development and heterogeneity of the ILC family 1
11.32 TNF IL6 IL1B
Sources

GO Terms for Decubitus Ulcer

About this section

Cellular components related to Decubitus Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 VEGFA TTR TNF PDGFB OSCAR NGF
2 endoplasmic reticulum lumen GO:0005788 9.65 PDGFB INS IL6 FN1 ALB
3 platelet alpha granule lumen GO:0031093 9.46 VEGFA PDGFB FN1 ALB
4 extracellular space GO:0005615 9.44 VEGFA TTR TNF PDGFB NGF MDS2

Biological processes related to Decubitus Ulcer according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.11 TNF PDGFB IL6 IL1B FGF7 FGF2
2 MAPK cascade GO:0000165 9.99 TNF PDGFB IL1B FGF7 FGF2
3 extracellular matrix organization GO:0030198 9.97 TTR TNF PDGFB FN1 FGF2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNF INS IL6 IL1B
5 cellular protein metabolic process GO:0044267 9.92 TTR INS IL6 FN1 ALB
6 platelet degranulation GO:0002576 9.91 VEGFA PDGFB FN1 ALB
7 positive regulation of MAPK cascade GO:0043410 9.9 PDGFB INS IL6 FGF2
8 positive regulation of protein kinase B signaling GO:0051897 9.88 TNF PDGFB INS FGF7 FGF2
9 cytokine-mediated signaling pathway GO:0019221 9.88 VEGFA TNF IL6 IL1B FN1 FGF2
10 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.86 VEGFA TNF NGF
11 response to wounding GO:0009611 9.85 PDGFB FN1 FGF7
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 VEGFA TNF IL6
13 positive regulation of endothelial cell proliferation GO:0001938 9.85 VEGFA PDGFB FGF2
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 VEGFA PDGFB IL6 FGF7
15 glucose metabolic process GO:0006006 9.84 TNF INS HECTD4
16 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 VEGFA TNF NGF IL6
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 TNF PDGFB IL6
18 positive regulation of interleukin-6 production GO:0032755 9.83 TNF IL6 IL1B
19 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.82 TNF PDGFB FGF2
20 positive regulation of blood vessel endothelial cell migration GO:0043536 9.82 VEGFA PDGFB FGF2
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.79 TNF PDGFB FGF2
22 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
23 positive regulation of MAP kinase activity GO:0043406 9.76 VEGFA TNF PDGFB FGF2
24 positive regulation of cell proliferation GO:0008284 9.76 VEGFA PDGFB INS IL6 IL1B FN1
25 positive regulation of mitotic nuclear division GO:0045840 9.75 PDGFB INS IL1B
26 positive regulation of protein autophosphorylation GO:0031954 9.73 VEGFA PDGFB INS
27 positive regulation of glial cell proliferation GO:0060252 9.69 TNF IL6 IL1B
28 negative regulation of blood vessel diameter GO:0097756 9.68 INS CRP
29 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
30 endothelial cell chemotaxis GO:0035767 9.67 VEGFA PLEKHG5
31 negative regulation of lipid catabolic process GO:0050995 9.67 TNF INS IL1B
32 paracrine signaling GO:0038001 9.65 PDGFB FGF2
33 positive regulation of fever generation GO:0031622 9.64 TNF IL1B
34 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
35 positive chemotaxis GO:0050918 9.62 VEGFA PDGFB FGF7 FGF2
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
37 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6 IL1B
38 acute-phase response GO:0006953 9.56 INS IL6 FN1 CRP
39 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
40 positive regulation of cell division GO:0051781 9.35 VEGFA PDGFB IL1B FGF7 FGF2
41 positive regulation of gene expression GO:0010628 9.28 VEGFA TNF PDGFB NGF INS IL6

Molecular functions related to Decubitus Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.81 VEGFA TTR TNF PDGFB INS FN1
2 cytokine activity GO:0005125 9.65 VEGFA TNF IL6 IL1B FGF2
3 heparin binding GO:0008201 9.62 VEGFA FN1 FGF7 FGF2
4 chemoattractant activity GO:0042056 9.26 VEGFA PDGFB FGF7 FGF2
5 growth factor activity GO:0008083 9.1 VEGFA PDGFB NGF IL6 FGF7 FGF2
Sources

Sources for Decubitus Ulcer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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