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MCID: DCB001
MIFTS: 62

Decubitus Ulcer

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Decubitus Ulcer

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MalaCards integrated aliases for Decubitus Ulcer:

Name: Decubitus Ulcer 12 15 17
Pressure Ulcer 12 54 44 71
Pressure Ulcers 15 62
Pressure Sores 12 42
Decubitus Ulcer Any Site 12
Decubitus Ulcer 12
Bedsore 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8717
ICD9CM 34 707.0
MeSH 44 D003668
NCIt 50 C50706
SNOMED-CT 67 28103007
ICD10 32 L89
UMLS 71 C0011127
Sources

Summaries for Decubitus Ulcer

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MedlinePlus : 42 Pressure sores are areas of damaged skin caused by staying in one position for too long. They commonly form where your bones are close to your skin, such as your ankles, back, elbows, heels and hips. You are at risk if you are bedridden, use a wheelchair, or are unable to change your position. Pressure sores can cause serious infections, some of which are life-threatening. They can be a problem for people in nursing homes. You can prevent the sores by Keeping skin clean and dry Changing position every two hours Using pillows and products that relieve pressure Pressure sores have a variety of treatments. Advanced sores are slow to heal, so early treatment is best.

MalaCards based summary : Decubitus Ulcer, also known as pressure ulcer, is related to ulcer of lower limbs and spinal cord injury, and has symptoms including pruritus and exanthema. An important gene associated with Decubitus Ulcer is TTR (Transthyretin), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs acetic acid and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.

PubMed Health : 62 About pressure ulcers: Some people inevitably spend a lot of time in a sitting or lying position. Most of them keep moving and shifting a little, consciously or subconsciously. But people who are extremely weak, paralyzed or unconscious may sit or lie motionless in the same position for a very long time. This puts them at greater risk of developing pressure ulcers (also called bedsores or pressure sores), which are open wounds caused by persistent external pressure against the skin. They can be very painful and usually take a long time to heal.

Wikipedia : 74 Pressure ulcers, also known as pressure sores or bed sores, are localised damage to the skin and/or... more...

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Related Diseases for Decubitus Ulcer

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Diseases related to Decubitus Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 923)
# Related Disease Score Top Affiliating Genes
1 ulcer of lower limbs 31.9 VEGFA TNF IL6 IL1B FGF2
2 spinal cord injury 31.1 TNF MMP9 IL6
3 cellulitis 30.5 TNF INS IL6 CRP ALB
4 purpura 30.4 TNF IL6 IL1B CRP
5 epidural abscess 30.4 CRP ALB
6 bacteriuria 30.4 IL6 CRP ALB
7 infective endocarditis 30.3 TNF IL6 CRP
8 kwashiorkor 30.3 TTR INS CRP ALB
9 peripheral vascular disease 30.2 VEGFA IL6 CRP ALB
10 nutritional deficiency disease 30.2 TTR IL6 IGF1 CRP ALB
11 syphilis 30.2 FN1 CRP ALB
12 acute transverse myelitis 30.2 MMP9 IL6
13 protein-energy malnutrition 30.2 TTR TNF IL6 IGF1 ALB
14 common cold 30.1 TNF IL6 IL1B ALB
15 severe acute respiratory syndrome 30.1 TNF IL6 IL1B CRP
16 spondylitis 30.1 TNF IL6 IL1B CRP
17 myelitis 30.1 TNF MMP9 IL6
18 neurogenic bladder 30.1 NGF CRP ALB
19 toxic shock syndrome 30.1 TNF IL6 IL1B CRP
20 marasmus 30.1 TTR INS IGF1 ALB
21 pneumocystosis 30.0 TNF IL6 CRP ALB
22 spinal cord disease 30.0 TNF IL6 IL1B CRP ALB
23 transverse myelitis 30.0 TNF MMP9 IL6
24 substance abuse 30.0 INS IL6 CRP ALB
25 necrotizing fasciitis 30.0 IL6 IL1B FN1 CRP ALB
26 rheumatic fever 30.0 TNF IL6 IL1A ALB
27 traumatic brain injury 29.9 IL6 IL1B IGF1
28 pneumonia 29.9 TTR TNF IL6 IL1B CRP ALB
29 peripheral artery disease 29.9 VEGFA TNF IL6 FGF2 CRP
30 adult respiratory distress syndrome 29.8 TNF IL6 IL1B FGF7 CALCA
31 acute cystitis 29.8 TNF INS IL6 IL1B CRP ALB
32 pain agnosia 29.8 TNF NGF IL6 IL1B CALCA ALB
33 brain injury 29.8 IL6 IL1B IGF1 ALB
34 hydrocephalus 29.8 VEGFA TTR TNF NGF IGF1
35 neuropathy 29.8 VEGFA TTR TNF NGF INS IL6
36 cerebrovascular disease 29.8 TTR TNF PECAM1 MMP9 INS IL6
37 disease by infectious agent 29.8 TNF IL6 IL1B CRP ALB
38 constipation 29.7 INS IL6 CRP CALCA ALB
39 limb ischemia 29.7 VEGFA TNF MMP9 IL6 FGF2
40 venous insufficiency 29.7 VEGFA MMP9 IL1A CRP
41 irritant dermatitis 29.7 TNF IL6 IL1B IL1A
42 endocarditis 29.7 TTR TNF IL6 IL1A CRP ALB
43 osteomyelitis 29.7 TNF IL6 IL1B IL1A CRP CALCA
44 hyperglycemia 29.7 INS IL6 IGF1 ALB
45 exanthem 29.7 VEGFA TNF IL6 IL1B CRP ALB
46 graft-versus-host disease 29.7 TNF IL6 IL1B IL1A
47 bursitis 29.6 TNF IL6 IL1B CRP CALCA
48 acute myocardial infarction 29.6 PECAM1 MMP9 IL6 CRP
49 plague 29.6 TNF PECAM1 IL6 IL1B ALB
50 cerebral palsy 29.6 TNF IL6 IL1B IGF1

Comorbidity relations with Decubitus Ulcer via Phenotypic Disease Network (PDN): (show top 50) (show all 104)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Conjunctivitis Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Aortic Valve Disease 1 Bacteremia 2
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Ulcer of Skin Communicating Hydrocephalus
Conjunctivitis Cystitis
Deficiency Anemia Dermatomycosis
Diabetes Mellitus, Ketosis-Prone Diabetic Polyneuropathy
Disseminated Intravascular Coagulation Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Erythematosquamous Dermatosis
Esophageal Candidiasis Esophageal Disease
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Folic Acid Deficiency Anemia Gas Gangrene
Generalized Atherosclerosis Heart Disease
Hepatic Encephalopathy Hydronephrosis
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma
Hypothyroidism Intestinal Obstruction
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Kidney Disease

Graphical network of the top 20 diseases related to Decubitus Ulcer:



Diseases related to Decubitus Ulcer
Sources

Symptoms & Phenotypes for Decubitus Ulcer

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UMLS symptoms related to Decubitus Ulcer:


pruritus, exanthema

MGI Mouse Phenotypes related to Decubitus Ulcer:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ALB CRP FGF2 FN1 IGF1 IL1A
2 homeostasis/metabolism MP:0005376 10.42 ALB CRP FGF2 FGF7 FN1 IGF1
3 hematopoietic system MP:0005397 10.36 FGF2 FGF7 FN1 IGF1 IL1A IL1B
4 immune system MP:0005387 10.35 ALB CRP FGF7 FN1 IGF1 IL1A
5 integument MP:0010771 10.23 FGF7 FN1 IGF1 IL1A IL1B IL6
6 muscle MP:0005369 10.18 ALB FGF2 FN1 IGF1 IL6 INS
7 digestive/alimentary MP:0005381 10.13 ALB IL6 INS MMP9 PECAM1 TNF
8 nervous system MP:0003631 10.1 FGF2 FGF7 FN1 IGF1 IL1B IL6
9 neoplasm MP:0002006 10.07 ALB FGF2 FN1 IGF1 IL1A IL1B
10 liver/biliary system MP:0005370 10.03 ALB FN1 IL6 INS PDGFB PECAM1
11 renal/urinary system MP:0005367 9.96 ALB FGF7 IGF1 IL6 INS MMP9
12 reproductive system MP:0005389 9.85 FGF2 FGF7 FN1 IGF1 IL6 INS
13 skeleton MP:0005390 9.73 FGF2 FGF7 FN1 IGF1 IL1B IL6
14 vision/eye MP:0005391 9.32 FGF2 FGF7 IL6 INS MMP9 NGF
Sources

Drugs & Therapeutics for Decubitus Ulcer

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PubMed Health treatment related to Decubitus Ulcer: 62

As much pressure as possible should be taken off of the pressure ulcer . The most important thing is to stop sitting or lying on the wound . Special positioning aids, special soft mattresses, and regular repositioning and movement help to relieve the pressure. Sterile wound dressings are usually used to protect the wound and help it to heal. If necessary, the wound is also regularly cleaned and dead tissue removed. The most appropriate treatment will depend on the type and severity of the pressure ulcer .

Drugs for Decubitus Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
acetic acid Approved Phase 4 64-19-7 176
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
St. John's Wort Approved, Investigational, Nutraceutical Phase 4 84082-80-4
7
Retinol acetate Phase 4 127-47-9 10245972
8 Olive Phase 4
9 Narcotics Phase 4
10 Analgesics, Opioid Phase 4
11 Anesthetics Phase 4
12 Anesthetics, Dissociative Phase 4
13 Excitatory Amino Acid Antagonists Phase 4
14 Anesthetics, Intravenous Phase 4
15 Neurotransmitter Agents Phase 4
16 Analgesics Phase 4
17 Anesthetics, General Phase 4
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
19
Colchicine Approved Phase 2, Phase 3 64-86-8 6167 2833
20
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
21
Emtricitabine Approved, Investigational Phase 2, Phase 3 143491-57-0 60877
22
Oxandrolone Approved, Investigational Phase 3 53-39-4 5878
23
Tenofovir Experimental, Investigational Phase 2, Phase 3 147127-20-6 464205
24 Anti-Infective Agents Phase 2, Phase 3
25 Antimetabolites Phase 2, Phase 3
26 Hypolipidemic Agents Phase 2, Phase 3
27 Lipid Regulating Agents Phase 2, Phase 3
28 Anticholesteremic Agents Phase 2, Phase 3
29 Antirheumatic Agents Phase 2, Phase 3
30 Antiviral Agents Phase 2, Phase 3
31 Anti-Inflammatory Agents Phase 2, Phase 3
32 Rosuvastatin Calcium Phase 2, Phase 3 147098-20-2
33 Anti-HIV Agents Phase 2, Phase 3
34 Antimitotic Agents Phase 2, Phase 3
35 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2, Phase 3
36 Reverse Transcriptase Inhibitors Phase 2, Phase 3
37 Tubulin Modulators Phase 2, Phase 3
38 Anti-Retroviral Agents Phase 2, Phase 3
39 Hormone Antagonists Phase 3
40 Hormones Phase 3
41 Anabolic Agents Phase 3
42 Androgens Phase 3
43
Morphine Approved, Investigational Phase 1, Phase 2 57-27-2 5288826
44
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2 8001-79-4
45
Betadex Experimental Phase 1, Phase 2 7585-39-9 320761
46 Antioxidants Phase 1, Phase 2
47 Protective Agents Phase 1, Phase 2
48 Respiratory System Agents Phase 1, Phase 2
49 Anti-Asthmatic Agents Phase 1, Phase 2
50 Endothelium-Dependent Relaxing Factors Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 276)
# Name Status NCT ID Phase Drugs
1 A 12-week, Single Site, Randomized Controlled Trial to Compare the Efficacy of Quantum NPWT With and Without Simultaneous Irrigation Versus Standard of Care on Reduction of the Volume of Stage III/IV Pressure Ulcers. Unknown status NCT01734109 Phase 4
2 A Monocentric, Comparative and Randomized Study on Pressure Ulcers Prevention With Mepilex® Border Sacrum Dressing in Scheduled Cardiovascular Surgery Unknown status NCT03823963 Phase 4
3 Olive Oil's Cream Effectiveness in Prevention of Pressure Ulcers in Immobilized Patients in Primary Care.A Cluster Randomized Clinical Trial. Unknown status NCT01595347 Phase 4 Hyper-oxigenated fatty acid
4 A Double-blind, Comparative, Superiority, Multi-centre Investigation Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers Completed NCT01036438 Phase 4
5 Evaluation of Wound Management for Sacral Pressure Ulcers With Necrotic Tissue Completed NCT02224638 Phase 4
6 A Multi-centre, Post CE-mark, Open Study to Evaluate the Performance of Thin Self-adherent Dressing Coated With a Soft Silicone Layer on Subjects With High Risk of Category 2 or Above Pressure Ulceration Completed NCT01438541 Phase 4
7 A Six Month Randomized Open-Label Trial of Pressure Ulcer Healing With Microcyn® Skin and Wound Care With Preservatives Versus Sterile Saline in Adult Spinal Cord Injury Subjects Completed NCT02001558 Phase 4 Microcyn
8 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation. Randomized Clinical Trial Completed NCT02526862 Phase 4
9 Determination of the 90% Effective Dose of a Sufentanil Bolus in Analgesia During Lateral Decubitus of Mechanically Ventilated Patients. Completed NCT01356732 Phase 4 Sufentanil
10 Effect of Prolonged Decubitus on Bronchial Inflammation in COPD Patients Evaluated by Expired NO Concentration Assessment Completed NCT01555593 Phase 4
11 A Prospective, Comparative, Single-centre Clinical Evaluation to Investigate the Skin-to-skin Time of the First Surgical Debridement of Lower Extremity Ulcers With VERSAJETâ„¢ Hydrosurgery System and Conventional Debridement Techniques. Completed NCT00521027 Phase 4
12 Different Radiation Exposures to Patient and Endoscopists Between Performing ERCP in Patients Lying Prone and Left Lateral Decubitus Completed NCT01599351 Phase 4
13 The Effect and Tolerance of a Ketamine Subcutaneous Bolus, During Painful Care of Refractory Bed Sores, Ulcers and Vascular Wounds in a Palliative Care Unit Terminated NCT02587130 Phase 4 Ketamine
14 A Randomized Controlled Trial of Enzymatic Debridement of Pressure Ulcers With Clostridial Collagenase Ointment (SANTYL®) or Hydrogel (SoloSite®) Terminated NCT02718625 Phase 4
15 A 12-week, Prospective, Open-label, Randomized, Controlled Clinical Trial Comparing Negative Pressure Wound Therapy (NPWT) to Standard Wound Care for the Treatment of Chronic Pressure Wounds of the Pelvic Region Terminated NCT00691821 Phase 4
16 Clinical Outcomes for Chronic Ulcers Treated With Clostridial Collagenase (SANTYL®) Versus Standard Care Within the Continuum of Care of an Accountable Care Organization (ACO) Withdrawn NCT02716519 Phase 4
17 Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers Withdrawn NCT02689310 Phase 4
18 A Prospective, Randomized, Controlled, Multi-Center, Study Evaluating AutoloGel Therapy for Complete Closure of Wagner Grade 1-4 Diabetic Foot Ulcers, Venous Leg Ulcers and Stage II-IV Pressure Ulcers Withdrawn NCT02248077 Phase 4
19 A Comparison of OASIS Wound Matrix With Approved Dressings for Split Thickness Skin Graft Donor Sites Withdrawn NCT02994589 Phase 4
20 Lifestyle Redesign for Pressure Ulcer Prevention in Spinal Cord Injury Completed NCT01999816 Phase 3
21 Pressure Ulcer Multi-disciplinary Teams Via Telemedicine (PUMTT): A Cluster Pragmatic Randomised Controlled Trial in Long Term Care Completed NCT01232764 Phase 3
22 Maggot Therapy for Wound Debridement: a Randomized Multicentric Double-blind Trial Completed NCT01211236 Phase 3
23 Preventing Pressure Ulcers: A Multi-site RCT in Nursing Facilities Completed NCT00665535 Phase 3
24 Interdisciplinary Mobility Approach To Reduction Of Facility-Acquired Pressure Ulcers Completed NCT01008254 Phase 2, Phase 3
25 Comparison of Two Turning Regimens (2 Versus Every 4 Hours) in the Prevention of Pressure Ulcers in Patients on Mechanical Ventilation That Use Alternating-pressure Air Mattresses. Completed NCT00847665 Phase 3
26 Efficacy of Prontosan Solution on Chronic Ulcers Completed NCT01333670 Phase 3 Isotonic solution (saline or lactated ringer)
27 Interdisciplinary Pressure Management & Mobility Program as an Alternative to Bed Rest: A Pilot Study Completed NCT00796042 Phase 3
28 A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Pressure Ulcers Recruiting NCT02312570 Phase 2, Phase 3
29 Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia: A Pragmatic Randomized Controlled Trial Recruiting NCT04359095 Phase 2, Phase 3 Emtricitabine/tenofovir;Colchicine Pill;Rosuvastatin
30 Impact of Skin Dressings Compared With Cream for Skin Lubrication in the Prevention of Pressure Ulcers in Patients at High or Very High Risk: A Multicenter Randomized Trial Terminated NCT02565745 Phase 3
31 CSP #535 - Anabolic Steroid Therapy on Pressure Ulcer Healing in Persons With Spinal Cord Injury Terminated NCT00101361 Phase 3 Oxandrolone;Placebo
32 Study Phase III, Randomized, Double-blind, Multicenter, National, to Evaluate the Non-inferiority in Efficacy of Investigational Product Regarding the Comparator Product, in Debridement of Devitalized Tissue in Uninfected Pressure Ulcers. Withdrawn NCT02004626 Phase 3 Collagenase;Kollagenase
33 A Randomized, Double-blind, Placebo-controlled Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Pressure Sore Unknown status NCT01351493 Phase 1, Phase 2 Nitric Oxide;placebo
34 A Randomized, Double-Blind, Placebo-Controlled, Dose Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients With Pressure Ulcers Completed NCT00382174 Phase 2 Placebo;Thymosin Beta 4
35 Enhancement of Pressure Healing With Pulsatile Lavage Completed NCT00047619 Phase 2
36 Insulin Complexation With Hydroxypropyl-beta-cyclodextrin: Spectroscopic Evaluation of Molecular Inclusion and Use of the Complex in Gel for Healing of Pressure Ulcers Completed NCT02418676 Phase 1, Phase 2 Gel with HPβCD-I complex;Gel with insulin;Control gel
37 Morphine-Infused Gel for Pressure Ulcer Analgesia Completed NCT00007254 Phase 1, Phase 2 Pain relief for pressure ulcers
38 Chronic Wounds Reference Nurse and Telematic Interconsultation Program for Pressure Ulcers in Primary Care: Evaluation of Effectiveness and Cost Reduction Completed NCT01877681 Phase 2
39 Treatment of Pressure Ulcers With Autologous Bone Marrow Stem Cells in Spinal Cord Injury Patients.Phase I/II Study. Completed NCT01572376 Phase 1, Phase 2
40 The Formation and Severity of Pressure Ulcers Associated With 4% Albumin vs. 0.9% Sodium Chloride Administration (Substudy of SAFE Protocol 153711) Completed NCT00228657 Phase 1, Phase 2 4% Albumin / 0.9% Sodium Chloride
41 A Randomized, Controlled Trial of the Procelleraâ„¢ Wound Dressing Used With Negative Pressure Wound Therapy (NPWT) in the Healing of Diabetic and Pressure Ulcers of the Foot Completed NCT01022216 Phase 2
42 Investigation of Subatmospheric Pressure Dressing on Pressure Ulcer Healing Completed NCT00011531 Phase 2
43 Adipose Derived Regenerative Cellular Therapy of Chronic Wounds Completed NCT02092870 Phase 2 Adipose derived stem cells
44 A Randomised, Double-blind, Placebo-controlled Study of the Safety and Efficacy of the Fruit-based Product OPAL A for the Treatment of Chronic Venous and Pressure Ulcers. Suspended NCT00933348 Phase 2 OPAL A;Placebo
45 Comparison of HP011-101 to Standard Care in the Management of Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury Terminated NCT01433159 Phase 2 HP011-101 (Xenaderm Ointment);Standard Care
46 A Clinical Trial on the Reduction of Bacteria (Including MRSA) in MRSA Positive Ulcers and Lesions Terminated NCT00771368 Phase 1, Phase 2 Nitric Oxide
47 An Open Randomised, Prospective, Crossover, Proof of Concept (Design Validation) Clinical Investigation to Caompare the Performance and Safety of Wound Dressing(Leia) Compared to and Hydroactive Surgical Dressing on Low to Highly Exuding Wounds Terminated NCT01966380 Phase 2
48 A Prospective, Randomised, Controlled, Open Study. Phase II Treatment Equivalent. Terminated NCT00429013 Phase 2
49 Comparison of HP011-101, HP828-101, and Standard Care in the Management of Stage I-II Pressure Ulcers in Patients With Spinal Cord Injury Withdrawn NCT01273428 Phase 2 HP011-101
50 Insulin Sensitivity in the Peri-Wound Microcirculation of Pressure Ulcers in SCI Withdrawn NCT02585765 Phase 2 Pioglitazone;Placebo

Search NIH Clinical Center for Decubitus Ulcer

Cochrane evidence based reviews: pressure ulcer

Sources

Genetic Tests for Decubitus Ulcer

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Anatomical Context for Decubitus Ulcer

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MalaCards organs/tissues related to Decubitus Ulcer:

40
Spinal Cord, Skin, Skeletal Muscle, Bone Marrow, Endothelial, Bone, Cervix
Sources

Publications for Decubitus Ulcer

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Articles related to Decubitus Ulcer:

(show top 50) (show all 4824)
# Title Authors PMID Year
1
Pressure ulcer prevention practices and associated factors among nurses in public hospitals of Harari regional state and Dire Dawa city administration, Eastern Ethiopia. 42 61
33320888 2020
2
SARS-CoV-2 not found in pressure injury exudates from COVID-19 patients. 42
33350028 2021
3
Identification of risk factors of developing pressure injuries among immobile patient, and a risk prediction model establishment: A protocol for systematic review. 42
33350742 2020
4
Assessment of a prognostic biochemical indicator of nutrition and inflammation for identification of pressure ulcer risk. 54 61
16505284 2006
5
Survey of nutritional status in newly hospitalized patients with stage III or stage IV pressure ulcers. 54 61
11075011 2000
6
Congenital Scoliosis of the Pediatric Cervical Spine: Characterization of a 17-Patient Operative Cohort. 61
33534366 2021
7
Investigating the Psychometric Properties of the Pieper-Zulkowski Pressure Ulcer Knowledge Test among Nurses in Iran. 61
33587479 2021
8
Predictors for readmission due to cellulitis among Japanese patients. 61
33523517 2021
9
Prevalence and characteristics of older people with pressure ulcers and legs ulcers, in nursing homes in Barcelona. 61
33485786 2021
10
Pediatric burn-trauma patients have increased length of stay compared to trauma-only patients: A propensity matched analysis. 61
33293153 2021
11
Sacral defect reconstruction using a sensate superior gluteal artery perforator flap based on the superior cluneal nerves: A report of two cases. 61
33528061 2021
12
Diabetic Foot Infection and Select Comorbidities Drive Readmissions in Outpatient Parenteral Antimicrobial Therapy. 61
33097196 2021
13
The mechanobiology theory of the development of medical device-related pressure ulcers revealed through a cell-scale computational modeling framework. 61
33606118 2021
14
Pressure injury and risk in the inpatient paediatric and neonatal populations: A single centre point-prevalence study. 61
33589375 2021
15
Disinfection capabilities of a 222 nm wavelength ultraviolet lighting device: a pilot study. 61
33573483 2021
16
Evaluating the impact of the Tissue Viability Seating guidelines. 61
33390309 2021
17
Development of the spinal cord injury pressure sore onset risk screening (SCI-PreSORS) instrument: a pressure injury risk decision tree for spinal cord injury rehabilitation. 61
32694750 2021
18
Power and sample size for multistate model analysis of longitudinal discrete outcomes in disease prevention trials. 61
33550652 2021
19
"Doctor, how long will it take?" Results from an historical cohort on surgical pressure ulcer healing delay and related factors in persons with spinal cord injury. 61
33579584 2021
20
Three-dimensional shape-conformation performances of wound dressings tested in a robotic sacral pressure ulcer phantom. 61
33605541 2021
21
Use of topical sevoflurane in pressure ulcer treatment in a double-lung transplant patient. 61
32873458 2021
22
Extraabdominal rupture of an inflammatory abdominal aortic aneurysm in a patient with aortodecubital fistula: a case report. 61
33556524 2021
23
Incidence of pressure ulcer in patients using an alternating pressure mattress overlay: the ACTIVE study. 61
33573487 2021
24
Examination of the psychometric properties of the Persian version of the attitude towards pressure ulcer prevention instrument in nurses. 61
33187791 2021
25
Vagococcus fluvialis as a causative pathogen of bloodstream and decubitus ulcer infection: Case report and systematic review of the literature. 61
33036895 2021
26
Using the 'aSSKINg' model in pressure ulcer prevention and care planning. 61
33491345 2021
27
Long-Term Success of Metal Endobronchial Stents in Lung Transplant Recipients. 61
33477176 2021
28
Hospital adverse outcomes of the elderly in a tertiary referral hospital: A prospective cohort study of 9,586 admissions. 61
33032184 2021
29
Impact of Person-Centered Interventions on Patient Outcomes in Acute Care Settings: A Systematic Review. 61
32032336 2021
30
Clinical application of a special postoperative position cushion for patients after percutaneous nephrolithotomy: a randomized trial. 61
33440966 2021
31
Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life. 61
33567047 2021
32
Development of Predictive Informatics Tool Using Electronic Health Records to Inform Personalized Evidence-Based Pressure Injury Management for Veterans with Spinal Cord Injury. 61
33499541 2021
33
Prophylactic dressings in the prevention of pressure ulcer related to the use of personal protective equipment by health professionals facing the COVID-19 pandemic: A randomized clinical trial. 61
33215768 2021
34
Comparison of four pressure ulcer risk assessment tools in critically ill patients. 61
32368844 2021
35
International comparison of pressure ulcer measures in long-term care facilities: Assessing the methodological robustness of 4 approaches to point prevalence measurement. 61
33558099 2021
36
Prone positioning as an emerging tool in the care provided to patients infected with COVID-19: a scoping review. 61
33439949 2021
37
Negative-pressure Wound Therapy for Sacral Pressure Ulcer in Gorham-Stout Disease. 61
33552805 2021
38
Study of the Relationship Between Pelvic Organ Prolapse Quantification (POP-Q) Staging and Decubitus Ulcer in Pelvic Organ Prolapse. 61
33552762 2021
39
The protective effect of statins against pressure ulcers in stroke patients: A propensity-score matched study based on a real-world database. 61
33333345 2021
40
Clinical Correlation Analysis of Complications in Elderly Patients with Sequelae of Stroke with Different Barthel Index in Tianjin Emergency Department. 61
33553425 2021
41
Effects of Attitude, Barriers/Facilitators, and Visual Differentiation on Oral Mucosa Pressure Ulcer Prevention Performance Intention. 61
33466903 2021
42
Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial. 61
33548748 2021
43
Positron emission tomography study of effects of two pressure-relieving support surfaces on pressure ulcer development. 61
33439081 2021
44
Squamous cell carcinoma arising from an ischial pressure ulcer initially suspected to be necrotizing soft tissue infection: A case report. 61
33461827 2021
45
Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial. 61
31241491 2021
46
Sacral and Ischial Pressure Ulcer Management With Negative-Pressure Wound Therapy With Instillation and Dwell. 61
33347064 2021
47
The impact of a pressure ulcer prevention educational program based on the health belief model for persons with spinal cord injury. 61
33465010 2021
48
Pressure distribution analysis of X-Ray table mattresses. 61
33339756 2020
49
Biomechanical monitoring and machine learning for the detection of lying postures. 61
33128961 2020
50
The functioning of social support in long-term prevention after spinal cord injury. A qualitative study. 61
33189942 2020
Sources

Variations for Decubitus Ulcer

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Expression for Decubitus Ulcer

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Search GEO for disease gene expression data for Decubitus Ulcer.
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Pathways for Decubitus Ulcer

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Pathways related to Decubitus Ulcer according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.25 VEGFA TTR TNF PDGFB NGF MMP9
2
Innate Immune System 65
Show member pathways
 14.04 VEGFA TTR TNF PECAM1 PDGFB OSCAR
3
Apoptotic Pathways in Synovial Fibroblasts 63
Show member pathways
 13.91 TNF PDGFB NGF MMP9 INS IL6
4
ERK Signaling 63
Show member pathways
 13.89 VEGFA TNF TMSB4X PDGFB NGF IL6
5
TGF-Beta Pathway 63
Show member pathways
 13.61 VEGFA TNF PDGFB NGF INS IL6
6
Developmental Biology 65
Show member pathways
 13.57 VEGFA TNF PDGFB MMP9 INS FN1
7
Akt Signaling 63
Show member pathways
 13.48 TNF PDGFB NGF IL6 IL1B IL1A
8
Cytokine Signaling in Immune system 65
Show member pathways
 13.43 VEGFA TNF PDGFB MMP9 IL6 IL1B
9
PAK Pathway 63
Show member pathways
 13.39 TNF PDGFB NGF IL6 IL1B IL1A
10
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.38 VEGFA TMSB4X PECAM1 PDGFB IGF1 FN1
11
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.34 VEGFA TNF PDGFB NGF IL6 IGF1
12
TNFR1 Pathway 63
Show member pathways
 13.15 VEGFA TNF NGF MMP9 IL6 IGF1
13
Phospholipase-C Pathway 63
Show member pathways
 13.14 PDGFB NGF IL6 IGF1 FN1 FGF7
14
p70S6K Signaling 63
Show member pathways
 13.13 PDGFB NGF INS IL6 IGF1 FGF7
15
PI3K-Akt signaling pathway 36
Show member pathways
 13.04 VEGFA TNF PDGFB NGF INS IL6
16
Human cytomegalovirus infection 36
Show member pathways
 13.01 VEGFA TNF PDGFB IL6 IL1B FGF2
17
Allograft rejection 36 1
Show member pathways
 12.93 VEGFA TNF INS IL6 IL1B IL1A
18
Pathways in cancer 36
12.91 VEGFA PDGFB MMP9 IL6 IGF1 FN1
19
Ras signaling pathway 36
Show member pathways
 12.84 VEGFA PDGFB NGF INS IGF1 FGF7
20
Degradation of the extracellular matrix 65
Show member pathways
 12.82 TTR PECAM1 PDGFB MMP9 FN1 FGF2
21
NF-KappaB Family Pathway 63
Show member pathways
 12.77 TNF PDGFB NGF IL6 IL1B IL1A
22
Glioma 36
Show member pathways
 12.75 PDGFB MMP9 IGF1 FGF7 FGF2
23
Regulation of actin cytoskeleton 36 1
12.73 TMSB4X PDGFB INS FN1 FGF7 FGF2
24
ErbB signaling pathway 36 1
Show member pathways
 12.69 VEGFA PDGFB IL6 IGF1 FGF2
25
Immune response IL-23 signaling pathway 23
Show member pathways
 12.69 TNF PDGFB IL6 IL1B FN1 FGF2
26
MAPK signaling pathway 36 1
12.62 VEGFA TNF PDGFB NGF INS IL1B
27
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.48 PDGFB NGF IL6 IGF1 FGF7 FGF2
28
Calcium signaling pathway 36
12.47 VEGFA PDGFB NGF FGF7 FGF2
29
Folate Metabolism 1
Show member pathways
 12.44 TNF INS IL6 IL1B CRP ALB
30
Toll Comparative Pathway 63
Show member pathways
 12.4 TNF IL6 IL1B IL1A FGF2
31
Proteoglycans in cancer 36
12.4 VEGFA TNF MMP9 IGF1 FN1 FGF2
32
IL-17 Family Signaling Pathways 64
Show member pathways
 12.39 TNF MMP9 IL6 IL1B
33
Tuberculosis 36
12.31 TNF IL6 IL1B IL1A
34
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.27 TNF PDGFB NGF IL6 IL1B IL1A
35
Colorectal Cancer Metastasis 63
12.26 VEGFA TNF MMP9 IL6
36
Bacterial infections in CF airways 23
Show member pathways
 12.26 TNF IL6 IL1B FN1
37
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.25 VEGFA TNF NGF IL6 IL1B IL1A
38
Yersinia infection 36
12.17 TNF IL6 IL1B FN1
39
Fluid shear stress and atherosclerosis 36
12.16 VEGFA TNF PECAM1 PDGFB MMP9 IL1B
40
Adipogenesis 1
12.15 TNF INS IL6 IGF1
41
Osteoclast differentiation 36
12.13 TNF OSCAR IL1B IL1A
42
Spinal Cord Injury 1
12.13 TNF MMP9 IL6 IL1B IL1A
43
TNF signaling pathway 36
12.06 TNF MMP9 IL6 IL1B
44
HIF-1 signaling pathway 36
12.05 VEGFA INS IL6 IGF1
45
Senescence and Autophagy in Cancer 1
12.05 INS IL6 IL1B IL1A IGF1 FN1
46
Amoebiasis 36
12.01 TNF IL6 IL1B FN1
47
AGE-RAGE signaling pathway in diabetic complications 36
12.01 VEGFA TNF IL6 IL1B IL1A FN1
48
Hematopoietic cell lineage 36
11.99 TNF IL6 IL1B IL1A
49
Rheumatoid arthritis 36
11.98 VEGFA TNF IL6 IL1B IL1A
50
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.98 PDGFB INS IL6 IGF1 FN1 FGF2
Sources

GO Terms for Decubitus Ulcer

About this section

Cellular components related to Decubitus Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 VEGFA TTR TNF PECAM1 PDGFB NGF
2 endoplasmic reticulum lumen GO:0005788 9.65 PDGFB INS IL6 FN1 ALB
3 platelet alpha granule lumen GO:0031093 9.63 VEGFA TMSB4X PDGFB IGF1 FN1 ALB
4 extracellular region GO:0005576 9.6 VEGFA TTR TNF TMSB4X PDGFB OSCAR

Biological processes related to Decubitus Ulcer according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 VEGFA TTR PECAM1 PDGFB INS IL6
2 positive regulation of transcription, DNA-templated GO:0045893 10.2 TNF PDGFB IL6 IL1B IGF1 FGF7
3 negative regulation of apoptotic process GO:0043066 10.16 VEGFA NGF MMP9 IL6 IGF1 ALB
4 inflammatory response GO:0006954 10.12 TNF IL6 IL1B IL1A CRP CALCA
5 negative regulation of gene expression GO:0010629 10.1 VEGFA TNF PDGFB IGF1 FGF2
6 positive regulation of cell proliferation GO:0008284 10.09 VEGFA PDGFB INS IL6 IL1B IGF1
7 MAPK cascade GO:0000165 10.08 TNF PDGFB IL1B FGF7 FGF2
8 extracellular matrix organization GO:0030198 10.08 TTR TNF PECAM1 PDGFB MMP9 FN1
9 positive regulation of cell migration GO:0030335 10.07 VEGFA PECAM1 PDGFB MMP9 INS IL1B
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 VEGFA TNF PDGFB FGF2
11 leukocyte migration GO:0050900 10.03 TNF PECAM1 MMP9 FN1
12 cellular response to lipopolysaccharide GO:0071222 10.03 TNF IL6 IL1B IL1A
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.02 TNF INS IL6 IL1B
14 positive regulation of angiogenesis GO:0045766 10.02 VEGFA IL1B IL1A FGF2
15 positive regulation of protein kinase B signaling GO:0051897 10.02 VEGFA TNF PDGFB INS FGF7 FGF2
16 cellular protein metabolic process GO:0044267 10.02 TTR INS IL6 IGF1 FN1 CALCA
17 positive regulation of protein phosphorylation GO:0001934 10 VEGFA TNF PECAM1 MMP9 IL1B FGF7
18 activation of MAPK activity GO:0000187 9.99 TNF IL1B IGF1 FGF2
19 wound healing GO:0042060 9.97 INS IGF1 FN1 FGF2
20 positive regulation of MAPK cascade GO:0043410 9.97 VEGFA PDGFB INS IL6 IGF1 FGF2
21 cytokine-mediated signaling pathway GO:0019221 9.97 VEGFA TNF MMP9 IL6 IL1B IL1A
22 positive regulation of interleukin-6 production GO:0032755 9.96 TNF IL6 IL1B IL1A
23 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.95 VEGFA TNF NGF IL6
24 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 VEGFA TNF IL6 IGF1
25 response to wounding GO:0009611 9.92 PDGFB FN1 FGF7
26 positive regulation of epithelial cell proliferation GO:0050679 9.92 VEGFA IGF1 FGF7 FGF2
27 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF PDGFB IL6 IGF1
28 regulation of insulin secretion GO:0050796 9.91 TNF IL6 IL1B
29 positive regulation of endothelial cell proliferation GO:0001938 9.91 VEGFA PDGFB FGF2
30 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.91 VEGFA TNF NGF
31 activation of protein kinase activity GO:0032147 9.91 VEGFA PDGFB CALCA
32 positive regulation of MAP kinase activity GO:0043406 9.91 VEGFA TNF PDGFB FGF2
33 positive regulation of interleukin-8 production GO:0032757 9.91 TNF IL6 IL1B CALCA
34 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.91 TNF PDGFB MMP9 IGF1 FGF2
35 positive regulation of cytokine production GO:0001819 9.9 TNF INS IL1A
36 positive regulation of fibroblast proliferation GO:0048146 9.9 PDGFB IGF1 FN1
37 monocyte chemotaxis GO:0002548 9.89 PDGFB IL6 CALCA
38 positive regulation of blood vessel endothelial cell migration GO:0043536 9.89 VEGFA TMSB4X PDGFB FGF2
39 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.88 TNF PDGFB FGF2
40 protein kinase B signaling GO:0043491 9.88 TNF IL1B IGF1
41 embryo implantation GO:0007566 9.88 MMP9 IL1B CALCA
42 positive chemotaxis GO:0050918 9.88 VEGFA PDGFB FGF7 FGF2
43 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 VEGFA PECAM1 PDGFB IL6 IGF1 FGF7
44 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 TNF IL1B IL1A
45 activation of protein kinase B activity GO:0032148 9.87 PDGFB INS IGF1
46 acute-phase response GO:0006953 9.87 INS IL6 FN1 CRP
47 positive regulation of DNA binding GO:0043388 9.86 NGF MMP9 IGF1
48 positive regulation of vascular endothelial growth factor production GO:0010575 9.85 IL6 IL1B IL1A
49 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
50 positive regulation of protein autophosphorylation GO:0031954 9.84 VEGFA PDGFB INS

Molecular functions related to Decubitus Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.73 VEGFA TNF IL6 IL1B IL1A FGF2
2 heparin binding GO:0008201 9.71 VEGFA FN1 FGF7 FGF2
3 identical protein binding GO:0042802 9.7 VEGFA TTR TNF PDGFB MMP9 INS
4 integrin binding GO:0005178 9.67 IL1B IGF1 FN1 FGF2
5 hormone activity GO:0005179 9.62 TTR INS IGF1 CALCA
6 collagen binding GO:0005518 9.61 PDGFB MMP9 FN1
7 chemoattractant activity GO:0042056 9.46 VEGFA PDGFB FGF7 FGF2
8 growth factor activity GO:0008083 9.17 VEGFA PDGFB NGF IL6 IGF1 FGF7
Sources

Sources for Decubitus Ulcer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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