MCID: DCB001
MIFTS: 61

Decubitus Ulcer

Categories: Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Decubitus Ulcer

MalaCards integrated aliases for Decubitus Ulcer:

Name: Decubitus Ulcer 11 14 16
Pressure Ulcer 11 53 43 71 75
Pressure Ulcers 14 63
Pressure Sores 11 41
Decubitus Ulcer Any Site 11
Decubitus Ulcer 11
Bedsore 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8717
ICD9CM 34 707.0
MeSH 43 D003668
NCIt 49 C50706
SNOMED-CT 68 28103007
ICD10 31 L89
UMLS 71 C0011127

Summaries for Decubitus Ulcer

MedlinePlus: 41 Pressure sores are areas of damaged skin caused by staying in one position for too long. They commonly form where your bones are close to your skin, such as your ankles, back, elbows, heels and hips. You are at risk if you are bedridden, use a wheelchair, or are unable to change your position. Pressure sores can cause serious infections, some of which are life-threatening. They can be a problem for people in nursing homes. You can prevent the sores by : Keeping skin clean and dry Changing position every two hours Using pillows and products that relieve pressure Pressure sores have a variety of treatments. Advanced sores are slow to heal, so early treatment is best.

MalaCards based summary: Decubitus Ulcer, also known as pressure ulcer, is related to ulcer of lower limbs and spinal cord injury, and has symptoms including pruritus and exanthema. An important gene associated with Decubitus Ulcer is TTR (Transthyretin), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Acetic acid and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

PubMed Health : 63 Pressure ulcers: Some people inevitably spend a lot of time in a sitting or lying position. Most of them keep moving and shifting a little, consciously or subconsciously. But people who are extremely weak, paralyzed or unconscious may sit or lie motionless in the same position for a very long time. This puts them at greater risk of developing pressure ulcers (also called bedsores or pressure sores), which are open wounds caused by persistent external pressure against the skin. They can be very painful and usually take a long time to heal.

Disease Ontology: 11 Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.

Wikipedia: 75 Pressure ulcers, also known as pressure sores, bed sores or pressure injuries, are localised damage to... more...

Related Diseases for Decubitus Ulcer

Diseases related to Decubitus Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1089)
# Related Disease Score Top Affiliating Genes
1 ulcer of lower limbs 31.7 VEGFA INS IL6 IL1B IGF1 FGF2
2 spinal cord injury 31.1 TNF MMP9 IL6
3 ischemia 30.7 VEGFA TNF MIR21 IL6 FGF2
4 osteomyelitis 30.4 TNF IL6 IL1B CXCL8 CRP
5 microvascular complications of diabetes 3 30.4 MIR21 INS ALB
6 fasciitis 30.3 TNF IL6 CXCL8
7 poliomyelitis 30.3 TNF IL6 ALB
8 rheumatic fever 30.3 TNF IL6 ALB
9 gas gangrene 30.3 TNF IL6 CRP ALB
10 nutritional deficiency disease 30.3 TTR IL6 IGF1 CRP ALB
11 neuromyelitis optica 30.3 IL6 IL1B CRP
12 protein-energy malnutrition 30.3 TTR TNF IL6 IGF1 ALB
13 pancytopenia 30.2 TTR IL6 CRP ALB
14 purpura 30.2 TNF IL6 IL1B CXCL8 CRP
15 bacteriuria 30.2 IL6 CXCL8 CRP ALB
16 spinal cord disease 30.2 VEGFA TNF IL6 ALB
17 bursitis 30.2 TNF IL6 IL1B CRP
18 chronic recurrent multifocal osteomyelitis 30.2 TNF IL6 IL1B CRP
19 spondylitis 30.2 TNF IL6 IL1B CRP
20 epidural abscess 30.2 CRP ALB
21 cellulitis 30.2 TNF INS IL6 IL1B CXCL8 CRP
22 transverse myelitis 30.1 TNF IL6 CRP
23 irritant dermatitis 30.1 TNF IL6 IL1B CXCL8
24 dermatitis 30.1 TNF IL6 IL1B CXCL8
25 infective endocarditis 30.1 IL6 FN1 CXCL8 CRP ALB
26 dementia 30.1 TTR TNF PDGFB NGF IL6 IL1B
27 diarrhea 30.1 TTR TNF IL6 IL1B CXCL8 ALB
28 coronary stenosis 30.1 MIR21 IL6 CRP
29 adult syndrome 30.1 TNF INS IL6 IGF1 CRP
30 severe cutaneous adverse reaction 30.1 TNF IL6 CRP
31 pain agnosia 30.1 TNF NGF INS IL6 IL1B CRP
32 pneumocystosis 30.1 TNF IL6 CRP ALB
33 kwashiorkor 30.1 TTR INS IGF1 CRP ALB
34 urinary tract infection 30.0 TNF INS IL6 IL1B CXCL8 CRP
35 venous insufficiency 30.0 VEGFA MMP9 CRP
36 marasmus 30.0 TTR INS IGF1 CRP ALB
37 hidradenitis 30.0 TNF IL1B CRP
38 hidradenitis suppurativa 30.0 TNF IL1B CRP
39 covid-19 30.0 TNF IL6 IL1B CXCL8 CRP
40 syphilis 30.0 TNF FN1 CRP ALB
41 cholecystitis 30.0 EGF CRP ALB
42 severe acute respiratory syndrome 30.0 TNF IL6 IL1B CXCL8 CRP
43 pfeiffer syndrome 30.0 TNF FGF7 FGF2 CRP
44 common cold 30.0 TNF IL6 IL1B CXCL8 CRP
45 toxic shock syndrome 30.0 TNF IL6 IL1B CXCL8 CRP
46 neurogenic bladder 30.0 NGF INS CRP ALB
47 short syndrome 30.0 TNF INS IL6 CRP
48 plague 30.0 TNF IL6 IL1B ALB
49 endocarditis 30.0 TTR TNF IL6 CXCL8 CRP ALB
50 disseminated intravascular coagulation 30.0 TNF IL6 FN1 CRP

Comorbidity relations with Decubitus Ulcer via Phenotypic Disease Network (PDN): (show top 50) (show all 105)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Conjunctivitis Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Alzheimer Disease, Familial, 1
Aortic Valve Disease 1 Bacteremia 2
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Kidney Disease Chronic Ulcer of Skin
Communicating Hydrocephalus Conjunctivitis
Cystitis Deficiency Anemia
Dermatomycosis Diabetes Mellitus, Ketosis-Prone
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Impaired Intellectual Development
Erythematosquamous Dermatosis Esophageal Candidiasis
Esophageal Disease Familial Atrial Fibrillation
Femoral Vein Thrombophlebitis Folic Acid Deficiency Anemia
Gas Gangrene Generalized Atherosclerosis
Heart Disease Hepatic Encephalopathy
Hydronephrosis Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Intestinal Obstruction Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia

Graphical network of the top 20 diseases related to Decubitus Ulcer:



Diseases related to Decubitus Ulcer

Symptoms & Phenotypes for Decubitus Ulcer

UMLS symptoms related to Decubitus Ulcer:


pruritus; exanthema

MGI Mouse Phenotypes related to Decubitus Ulcer:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ALB CRP FGF2 FGF7 FN1 IGF1
2 nervous system MP:0003631 10.26 FGF2 FGF7 FN1 IGF1 IL1B IL6
3 muscle MP:0005369 10.17 ALB FGF2 FN1 IGF1 IL6 INS
4 cardiovascular system MP:0005385 10.17 ALB CRP FGF2 FN1 IGF1 IL1B
5 neoplasm MP:0002006 10.15 ALB FGF2 FN1 IGF1 IL1B IL6
6 renal/urinary system MP:0005367 10.11 ALB FGF7 IGF1 IL6 INS MMP9
7 immune system MP:0005387 10.07 ALB CRP EGF FGF7 FN1 IGF1
8 digestive/alimentary MP:0005381 9.97 ALB EGF IL6 INS MMP9 TNF
9 reproductive system MP:0005389 9.9 EGF FGF2 FGF7 FN1 IGF1 IL6
10 vision/eye MP:0005391 9.7 EGF FGF2 FGF7 IL6 INS MMP9
11 integument MP:0010771 9.4 EGF FGF7 FN1 IGF1 IL1B IL6

Drugs & Therapeutics for Decubitus Ulcer

PubMed Health treatment related to Decubitus Ulcer: 63

As much pressure as possible should be taken off of the pressure ulcer . The most important thing is to stop sitting or lying on the wound . Special positioning aids, special soft mattresses, and regular repositioning and movement help to relieve the pressure. Sterile wound dressings are usually used to protect the wound and help it to heal. If necessary, the wound is also regularly cleaned and dead tissue removed. The most appropriate treatment will depend on the type and severity of the pressure ulcer .

Drugs for Decubitus Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 131)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetic acid Approved Phase 4 64-19-7 176
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
6
St. John's Wort Approved, Investigational, Nutraceutical Phase 4 84082-80-4
7
Zuretinol acetate Investigational Phase 4 127-47-9, 29584-22-3 10245972
8 Dsuvia Phase 4
9 Analgesics, Opioid Phase 4
10 Narcotics Phase 4
11 Neurotransmitter Agents Phase 4
12 Anesthetics Phase 4
13 Anesthetics, Intravenous Phase 4
14 Anesthetics, General Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Anesthetics, Dissociative Phase 4
17 Analgesics Phase 4
18
Oxandrolone Approved, Investigational Phase 3 53-39-4 5878
19 Anabolic Agents Phase 3
20 Hormones Phase 3
21 Hormone Antagonists Phase 3
22 Androgens Phase 3
23
Morphine Approved, Investigational Phase 1, Phase 2 57-27-2 5288826
24
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2 8001-79-4 96919
25
Betadex Experimental Phase 1, Phase 2 7585-39-9 320761
26 Bronchodilator Agents Phase 1, Phase 2
27 Anti-Asthmatic Agents Phase 1, Phase 2
28 Endothelium-Dependent Relaxing Factors Phase 1, Phase 2
29 Vasodilator Agents Phase 1, Phase 2
30 Respiratory System Agents Phase 1, Phase 2
31 Antioxidants Phase 1, Phase 2
32 Protective Agents Phase 1, Phase 2
33 Castor Phase 2
34
Arginine Approved, Investigational, Nutraceutical Phase 1 74-79-3 6322
35
L-Glutamine Approved, Investigational, Nutraceutical Phase 1 56-85-9 5961
36 Fibrin Tissue Adhesive Phase 1
37
D-Leucine Experimental, Investigational, Nutraceutical Phase 1 328-38-1, 61-90-5 439524 6106
38
Cefazolin Approved 25953-19-9 33255
39
Sodium citrate Approved, Investigational 68-04-2 23431961
40
Polihexanide Approved, Investigational 28757-47-3 20977
41
Coal tar Approved 8007-45-2
42
Sage Approved
43
Etoposide Approved 33419-42-0 36462
44
Levoleucovorin Approved, Experimental, Investigational 68538-85-2, 58-05-9, 73951-54-9 149436 6006
45
Methotrexate Approved 1959-05-2, 59-05-2 4112 126941
46
Cytarabine Approved, Investigational 147-94-4 6253
47
Caffeine Approved 58-08-2 2519
48
Chlorhexidine Approved, Vet_approved, Withdrawn 55-56-1 2713 9552079
49
Calcium polycarbophil Approved 126040-58-2
50
Urethane Approved, Withdrawn 51-79-6 5641

Interventional clinical trials:

(show top 50) (show all 292)
# Name Status NCT ID Phase Drugs
1 A Monocentric, Comparative and Randomized Study on Pressure Ulcers Prevention With Mepilex® Border Sacrum Dressing in Scheduled Cardiovascular Surgery Unknown status NCT03823963 Phase 4
2 Olive Oil's Cream Effectiveness in Prevention of Pressure Ulcers in Immobilized Patients in Primary Care.A Cluster Randomized Clinical Trial. Unknown status NCT01595347 Phase 4 Hyper-oxigenated fatty acid
3 A 12-week, Single Site, Randomized Controlled Trial to Compare the Efficacy of Quantum NPWT With and Without Simultaneous Irrigation Versus Standard of Care on Reduction of the Volume of Stage III/IV Pressure Ulcers. Unknown status NCT01734109 Phase 4
4 A Prospective, Comparative, Single-centre Clinical Evaluation to Investigate the Skin-to-skin Time of the First Surgical Debridement of Lower Extremity Ulcers With VERSAJET™ Hydrosurgery System and Conventional Debridement Techniques. Completed NCT00521027 Phase 4
5 A Six Month Randomized Open-Label Trial of Pressure Ulcer Healing With Microcyn® Skin and Wound Care With Preservatives Versus Sterile Saline in Adult Spinal Cord Injury Subjects Completed NCT02001558 Phase 4 Microcyn
6 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation. Randomized Clinical Trial Completed NCT02526862 Phase 4
7 Different Radiation Exposures to Patient and Endoscopists Between Performing ERCP in Patients Lying Prone and Left Lateral Decubitus Completed NCT01599351 Phase 4
8 A Multi-centre, Post CE-mark, Open Study to Evaluate the Performance of Thin Self-adherent Dressing Coated With a Soft Silicone Layer on Subjects With High Risk of Category 2 or Above Pressure Ulceration Completed NCT01438541 Phase 4
9 Determination of the 90% Effective Dose of a Sufentanil Bolus in Analgesia During Lateral Decubitus of Mechanically Ventilated Patients. Completed NCT01356732 Phase 4 Sufentanil
10 Evaluation of Wound Management for Sacral Pressure Ulcers With Necrotic Tissue Completed NCT02224638 Phase 4
11 Effect of Prolonged Decubitus on Bronchial Inflammation in COPD Patients Evaluated by Expired NO Concentration Assessment Completed NCT01555593 Phase 4
12 Evaluation of Vacuum-Assisted Closure Veraflo Therapy With Cleanse Choice Dressing on Wound Healing in Patients With Pressure Sores: A Prospective, Randomized Controlled Trial Recruiting NCT05598398 Phase 4
13 A Randomized Controlled Trial of Enzymatic Debridement of Pressure Ulcers With Clostridial Collagenase Ointment (SANTYL®) or Hydrogel (SoloSite®) Terminated NCT02718625 Phase 4
14 A 12-week, Prospective, Open-label, Randomized, Controlled Clinical Trial Comparing Negative Pressure Wound Therapy (NPWT) to Standard Wound Care for the Treatment of Chronic Pressure Wounds of the Pelvic Region Terminated NCT00691821 Phase 4
15 The Effect and Tolerance of a Ketamine Subcutaneous Bolus, During Painful Care of Refractory Bed Sores, Ulcers and Vascular Wounds in a Palliative Care Unit Terminated NCT02587130 Phase 4 Ketamine
16 Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers Withdrawn NCT02689310 Phase 4
17 A Prospective, Randomized, Controlled, Multi-Center, Study Evaluating AutoloGel Therapy for Complete Closure of Wagner Grade 1-4 Diabetic Foot Ulcers, Venous Leg Ulcers and Stage II-IV Pressure Ulcers Withdrawn NCT02248077 Phase 4
18 Clinical Outcomes for Chronic Ulcers Treated With Clostridial Collagenase (SANTYL®) Versus Standard Care Within the Continuum of Care of an Accountable Care Organization (ACO) Withdrawn NCT02716519 Phase 4
19 Lifestyle Redesign for Pressure Ulcer Prevention in Spinal Cord Injury Completed NCT01999816 Phase 3
20 Preventing Pressure Ulcers: A Multi-site RCT in Nursing Facilities Completed NCT00665535 Phase 3
21 Interdisciplinary Pressure Management & Mobility Program as an Alternative to Bed Rest: A Pilot Study Completed NCT00796042 Phase 3
22 Comparison of Two Turning Regimens (2 Versus Every 4 Hours) in the Prevention of Pressure Ulcers in Patients on Mechanical Ventilation That Use Alternating-pressure Air Mattresses. Completed NCT00847665 Phase 3
23 Interdisciplinary Mobility Approach To Reduction Of Facility-Acquired Pressure Ulcers Completed NCT01008254 Phase 2, Phase 3
24 Pressure Ulcer Multi-disciplinary Teams Via Telemedicine (PUMTT): A Cluster Pragmatic Randomised Controlled Trial in Long Term Care Completed NCT01232764 Phase 3
25 Efficacy of Prontosan Solution on Chronic Ulcers Completed NCT01333670 Phase 3 Isotonic solution (saline or lactated ringer)
26 Maggot Therapy for Wound Debridement: a Randomized Multicentric Double-blind Trial Completed NCT01211236 Phase 3
27 Impact of Skin Dressings Compared With Cream for Skin Lubrication in the Prevention of Pressure Ulcers in Patients at High or Very High Risk: A Multicenter Randomized Trial Terminated NCT02565745 Phase 3
28 CSP #535 - Anabolic Steroid Therapy on Pressure Ulcer Healing in Persons With Spinal Cord Injury Terminated NCT00101361 Phase 3 Oxandrolone;Placebo
29 Study Phase III, Randomized, Double-blind, Multicenter, National, to Evaluate the Non-inferiority in Efficacy of Investigational Product Regarding the Comparator Product, in Debridement of Devitalized Tissue in Uninfected Pressure Ulcers. Withdrawn NCT02004626 Phase 3 Collagenase;Kollagenase
30 A Randomized, Double-blind, Placebo-controlled Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Pressure Sore Unknown status NCT01351493 Phase 1, Phase 2 Nitric Oxide;placebo
31 The Formation and Severity of Pressure Ulcers Associated With 4% Albumin vs. 0.9% Sodium Chloride Administration (Substudy of SAFE Protocol 153711) Completed NCT00228657 Phase 1, Phase 2 4% Albumin / 0.9% Sodium Chloride
32 A Randomized, Double-Blind, Placebo-Controlled, Dose Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients With Pressure Ulcers Completed NCT00382174 Phase 2 Placebo;Thymosin Beta 4
33 Chronic Wounds Reference Nurse and Telematic Interconsultation Program for Pressure Ulcers in Primary Care: Evaluation of Effectiveness and Cost Reduction Completed NCT01877681 Phase 2
34 Adipose Derived Regenerative Cellular Therapy of Chronic Wounds Completed NCT02092870 Phase 2 Adipose derived stem cells
35 Insulin Complexation With Hydroxypropyl-beta-cyclodextrin: Spectroscopic Evaluation of Molecular Inclusion and Use of the Complex in Gel for Healing of Pressure Ulcers Completed NCT02418676 Phase 1, Phase 2 Gel with HPβCD-I complex;Gel with insulin;Control gel
36 A Randomized, Controlled Trial of the Procellera™ Wound Dressing Used With Negative Pressure Wound Therapy (NPWT) in the Healing of Diabetic and Pressure Ulcers of the Foot Completed NCT01022216 Phase 2
37 Investigation of Subatmospheric Pressure Dressing on Pressure Ulcer Healing Completed NCT00011531 Phase 2
38 Morphine-Infused Gel for Pressure Ulcer Analgesia Completed NCT00007254 Phase 1, Phase 2 Pain relief for pressure ulcers
39 Treatment of Pressure Ulcers With Autologous Bone Marrow Stem Cells in Spinal Cord Injury Patients.Phase I/II Study. Completed NCT01572376 Phase 1, Phase 2
40 A Randomized, Double-blind Study to Evaluate the Safety, Tolerability, and Potential Efficacy of BACTELIDE vs. Placebo in Addition to Standard-of-care Therapy for S. Aureus, P. Aeruginosa, and K. Pneumoniae Colonized Pressure Injuries Not yet recruiting NCT04815798 Phase 1, Phase 2
41 A Phase IIa Study to Investigate the Efficacy and Safety Profile of GM-XANTHO in Pressure Ulcer Patients Not yet recruiting NCT05199077 Phase 2 GM-XANTHO
42 A Randomised, Double-blind, Placebo-controlled Study of the Safety and Efficacy of the Fruit-based Product OPAL A for the Treatment of Chronic Venous and Pressure Ulcers. Suspended NCT00933348 Phase 2 OPAL A;Placebo
43 An Open Randomised, Prospective, Crossover, Proof of Concept (Design Validation) Clinical Investigation to Caompare the Performance and Safety of Wound Dressing(Leia) Compared to and Hydroactive Surgical Dressing on Low to Highly Exuding Wounds Terminated NCT01966380 Phase 2
44 A Clinical Trial on the Reduction of Bacteria (Including MRSA) in MRSA Positive Ulcers and Lesions Terminated NCT00771368 Phase 1, Phase 2 Nitric Oxide
45 A Prospective, Randomised, Controlled, Open Study. Phase II Treatment Equivalent. Terminated NCT00429013 Phase 2
46 Comparison of HP011-101 to Standard Care in the Management of Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury Terminated NCT01433159 Phase 2 HP011-101 (Xenaderm Ointment);Standard Care
47 Insulin Sensitivity in the Peri-Wound Microcirculation of Pressure Ulcers in SCI Withdrawn NCT02585765 Phase 2 Pioglitazone;Placebo
48 Comparison of HP011-101, HP828-101, and Standard Care in the Management of Stage I-II Pressure Ulcers in Patients With Spinal Cord Injury Withdrawn NCT01273428 Phase 2 HP011-101
49 Effect of Hematopoietic Stem Cells in Chronic Wounds Using a Pressure Sore Model: A Pilot Study on Feasibility, Safety and Potential Effects Unknown status NCT00535548 Phase 1
50 BION Active Seating for Pressure Ulcer Prevention Completed NCT00628602 Phase 1

Search NIH Clinical Center for Decubitus Ulcer

Cochrane evidence based reviews: pressure ulcer

Genetic Tests for Decubitus Ulcer

Anatomical Context for Decubitus Ulcer

Organs/tissues related to Decubitus Ulcer:

MalaCards : Skin, Spinal Cord, Bone Marrow, Brain, Bone, Lung, Skeletal Muscle

Publications for Decubitus Ulcer

Articles related to Decubitus Ulcer:

(show top 50) (show all 11511)
# Title Authors PMID Year
1
Efficacy and Safety of Topical Application of Olive Oil for Preventing Pressure Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 62 41
36429639 2022
2
Development and Validation of a Meta-Instrument for Nursing Assessment in Adult Hospitalization Units (VALENF Instrument) (Part I). 62 41
36429341 2022
3
A rare clinical image of fourth-degree bedsore. 62 41
36405658 2022
4
Inflammation and disability as risk factors for mortality in elderly acute care patients. 53 62
18456352 2009
5
Assessment of a prognostic biochemical indicator of nutrition and inflammation for identification of pressure ulcer risk. 53 62
16505284 2006
6
Survey of nutritional status in newly hospitalized patients with stage III or stage IV pressure ulcers. 53 62
11075011 2000
7
Facilitation of immune function, healing of pressure ulcers, and nutritional status in spinal cord injury patients. 53 62
10640453 2000
8
Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double-blind, placebo-controlled study. 53 62
10417749 1999
9
Becaplermin. 53 62
18031145 1999
10
Clostridium ramosum bacteremia: A case series at a general acute care hospital. 62
36154869 2023
11
Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges. 62
36459193 2022
12
Using Community Detection Techniques to Identify Themes in COVID-19-Related Patient Safety Event Reports. 62
36112536 2022
13
Epidemiology of spinal cord injury in China: A systematic review of the chinese and english literature. 62
35778501 2022
14
Spinal infection with intraspinal abscess or empyema and acute myelopathy: comparative analysis of diagnostics, therapy, complications and outcome in primary care. 62
35657387 2022
15
Influence of time to surgery on clinical outcomes in elderly hip fracture patients : an assessment of surgical postponement due to non-medical reasons. 62
36453044 2022
16
A Systematic Review of Oral Nutritional Supplement and Wound Healing. 62
35043693 2022
17
Outcomes following conservative treatment of extension fractures in the setting of diffuse idiopathic skeletal hyperostosis: is external orthosis alone a reasonable option? 62
35932260 2022
18
Effect of Chinese herbal topical medicine, acupuncture, and moxibustion on pressure ulcer wound healing: A meta-analysis. 62
35396823 2022
19
Psychometric properties of the Chinese version of the attitude towards pressure ulcer prevention instrument: A cross-sectional survey. 62
35307948 2022
20
Phenytoin-loaded bioactive nanoparticles for the treatment of diabetic pressure ulcers: formulation and in vitro/in vivo evaluation. 62
35403947 2022
21
Factors affecting the incidence and prevalence of pressure ulcers in COVID-19 patients admitted with a Braden scale below 14 in the intensive care unit: Retrospective cohort study. 62
35322547 2022
22
Adverse events: an expensive and avoidable hospital problem. 62
36369717 2022
23
Exploration of an objective and simple index as the outcome of nutrition support for elderly patients and identification of risk factors. 62
35655002 2022
24
Impact of family visit restrictions due to COVID-19 policy on patient outcomes: A cohort study. 62
35699245 2022
25
Effects of Nurse Staffing on Resident Outcomes in Nursing Homes: A Systematic Review. 62
36470321 2022
26
Pressure ulcer risk profiles of hospitalized patients based on the Braden Scale: A cluster analysis. 62
35068026 2022
27
Factors Associated with Intensive Care Units' Nurses Frequency of Performing Pressure Injury Prevention: A Cross-sectional Study. 62
36473718 2022
28
Hospital-acquired pressure ulcers prevention: What is needed for patient safety? The perceptions of nurse stakeholders. 62
34105825 2022
29
Sources of nurse-sensitive inpatient safety improvement. 62
35362160 2022
30
Relationship between mattress internal air pressure and interface pressure distribution in the lateral position. 62
35474638 2022
31
A Prospective Study of Pressure Injury Healing Rate and Time and Influencing Factors in an Acute Care Setting. 62
36409189 2022
32
Pressure-sensitive antibacterial hydrogel dressing for wound monitoring in bed ridden patients. 62
35901573 2022
33
Post-operative Use of Cervical Orthoses for Subaxial Cervical Spine Injuries - a Survey-based Analysis at German Spine Care Centres. 62
34496425 2022
34
The Return on Investment value of integrating the WHO Patient Safety Curriculum in Nursing Diploma: Forecasting case study. 62
36212582 2022
35
Evidence for publicly reported quality indicators in residential long-term care: a systematic review. 62
36424603 2022
36
Chemical profile of the pits oil from the Tunisian "Alig" cultivar of Phoenix dactylifera L.: In vivo wound healing potential evaluation of a cream formulated from the extracted oil and insights from molecular docking and SAR analysis. 62
36325999 2022
37
The relationship between patient safety culture and patient safety competency with adverse events: a multicenter cross-sectional study. 62
36319970 2022
38
Prolonged stay at an acute-care hospital in Israel among older adults awaiting transfer to post-acute care: retrospective study on risk factors and consequences. 62
36417176 2022
39
Comparison of the effectiveness of assisted turning mattresses and conventional air mattresses in relieving body pressure in different lying positions. 62
36445182 2022
40
Nursing Assessment of Pressure Injury Risk with the Braden Scale Validated against Sensor-Based Measurement of Movement. 62
36421654 2022
41
Effect of changing the lying posture angle by changing the bed posture on the average pressure, maximum pressure, and pressure area in the hip region. 62
36442161 2022
42
Simple Diverting Colostomy for Sacral Pressure Ulcers: Not So Simple After All. 62
36400903 2022
43
Prevalence of Friction Skin Injury on the Buttocks and/or Posterior Thighs in an Acute Care Setting: A Quality Improvement Project. 62
36417373 2022
44
Secondary Autologous Fat Grafting for the Treatment of Chin Necrosis as a Consequence of Prone Position in COVID-19 Patients. 62
36415619 2022
45
Preventing facial pressure injuries among health care staff working in diverse COVID-19 care environments. 62
35146927 2022
46
Preoperative Pressure Ulcers, Mortality, and Complications in Older Hip Fracture Surgery Patients. 62
36322619 2022
47
Impact of advanced practice nurses in hospital units on compliance with clinical practice guidelines: a quasi-experimental study. 62
36447167 2022
48
Repositioning mattress: how a lateral tilt position reshapes the prevention of pressure ulcers in bedridden patients. 62
35801990 2022
49
The knowledge and attitudes regarding pressure ulcer prevention among healthcare support workers in the UK: A cross-sectional study. 62
36464578 2022
50
The impact of a pressure ulcer prevention educational program based on the health belief model for persons with spinal cord injury. 62
33465010 2022

Variations for Decubitus Ulcer

Expression for Decubitus Ulcer

Search GEO for disease gene expression data for Decubitus Ulcer.

Pathways for Decubitus Ulcer

Pathways related to Decubitus Ulcer according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF PDGFB NGF MMP9 INS IL6
2
Show member pathways
13.91 VEGFA TNF PDGFB NGF IL6 IL1B
3 13.84 VEGFA TNF PDGFB NGF MMP9 INS
4
Show member pathways
13.76 VEGFA PDGFB NGF MMP9 IL6 IGF1
5
Show member pathways
13.62 CRP EGF FGF2 FGF7 IGF1 IL6
6
Show member pathways
13.61 VEGFA TNF PDGFB NGF INS IL6
7
Show member pathways
13.54 VEGFA TNF PDGFB IL6 IL1B IGF1
8
Show member pathways
13.51 TNF PDGFB NGF IL6 IL1B IGF1
9
Show member pathways
13.4 CXCL8 FGF2 FN1 IL1B IL6 MMP9
10
Show member pathways
13.4 TNF PDGFB NGF IL6 IL1B IGF1
11
Show member pathways
13.39 PDGFB NGF IL6 IGF1 FGF7 FGF2
12
Show member pathways
13.37 VEGFA TNF SLC7A1 PDGFB NGF IL6
13
Show member pathways
13.18 PDGFB NGF IL6 IGF1 FN1 FGF7
14
Show member pathways
13.16 PDGFB NGF INS IL6 IGF1 FGF7
15
Show member pathways
13.05 VEGFA PDGFB NGF INS IL6 IGF1
16
Show member pathways
12.99 VEGFA TNF NGF IGF1 FN1 EGF
17
Show member pathways
12.9 TNF MMP9 IL6 IL1B CXCL8
18 12.9 VEGFA PDGFB NGF MMP9 INS IGF1
19
Show member pathways
12.8 TTR PDGFB MMP9 FN1 FGF2
20
Show member pathways
12.8 TNF PDGFB NGF IL6 IL1B IGF1
21
Show member pathways
12.75 PDGFB INS FGF7 FGF2 EGF
22
Show member pathways
12.71 TNF PDGFB IL6 IL1B FN1 FGF2
23
Show member pathways
12.7 TNF PDGFB NGF IL6 IL1B IGF1
24
Show member pathways
12.57 TNF IL6 IL1B CXCL8
25
Show member pathways
12.55 PDGFB IGF1 FGF7 FGF2 EGF
26 12.52 TNF PDGFB NGF IL1B FGF7 FGF2
27
Show member pathways
12.51 TNF IL6 IL1B FN1 CXCL8
28
Show member pathways
12.51 PDGFB NGF IL6 IGF1 FGF7 FGF2
29
Show member pathways
12.45 VEGFA FGF7 FGF2 EGF
30
Show member pathways
12.44 IL6 IGF1 FN1 ALB
31
Show member pathways
12.41 TNF IL6 IL1B FGF2 CXCL8
32 12.4 VEGFA PDGFB IGF1 FN1 EGF
33
Show member pathways
12.35 TNF MMP9 IL6 CXCL8
34 12.32 VEGFA TNF MMP9 IL6 EGF
35 12.31 CXCL8 IL1B IL6 NGF TNF VEGFA
36
Show member pathways
12.27 FGF2 FN1 PDGFB TTR
37 12.27 PDGFB FN1 FGF7 FGF2 EGF
38
Show member pathways
12.26 TNF MIR21 IGF1 FGF2 EGF
39 12.23 TNF NGF IL6 IL1B IGF1 FGF2
40 12.15 IGF1 IL6 INS TNF
41
Show member pathways
12.13 VEGFA MMP9 IGF1 FGF2
42 12.13 CXCL8 IL1B IL6 MMP9 TNF
43 12.07 INS IL6 IL1B IGF1 FN1 CXCL8
44 12.03 CXCL8 FGF2 FN1 IL6 VEGFA
45 12.01 VEGFA PDGFB NGF MMP9 INS IL6
46 11.98 VEGFA TNF IL1B CXCL8
47 11.98 PDGFB INS IL6 IGF1 FN1 FGF2
48 11.96 VEGFA TNF MMP9 IL6 IL1B FN1
49 11.94 EGF FGF2 IGF1 NGF PDGFB VEGFA
50 11.93 VEGFA PDGFB INS IL6 IGF1 FGF7

GO Terms for Decubitus Ulcer

Cellular components related to Decubitus Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.19 ALB CRP CXCL8 EGF FGF2 FGF7
2 platelet alpha granule lumen GO:0031093 9.93 VEGFA PDGFB IGF1 FN1 EGF ALB
3 extracellular space GO:0005615 9.88 ALB CRP CXCL8 EGF FGF2 FGF7

Biological processes related to Decubitus Ulcer according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.6 VEGFA TTR TNF PDGFB INS IL6
2 positive regulation of DNA-templated transcription GO:0045893 10.58 EGF FGF2 FGF7 IGF1 IL1B IL6
3 negative regulation of apoptotic process GO:0043066 10.45 VEGFA TNF MMP9 MIR21 IL6 IGF1
4 negative regulation of cell population proliferation GO:0008285 10.38 CXCL8 FGF2 IL1B IL6 MIR21 NGF
5 angiogenesis GO:0001525 10.36 CXCL8 EGF FGF2 FN1 VEGFA
6 positive regulation of cell migration GO:0030335 10.36 VEGFA PDGFB MIR21 INS IL1B IGF1
7 negative regulation of gene expression GO:0010629 10.35 VEGFA TNF PDGFB MIR21 INS IGF1
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.32 FGF2 IGF1 MIR21 PDGFB TNF VEGFA
9 positive regulation of protein phosphorylation GO:0001934 10.32 VEGFA TNF MMP9 MIR21 IL1B FGF7
10 defense response to Gram-positive bacterium GO:0050830 10.31 TNF IL6 IL1B CRP
11 positive regulation of angiogenesis GO:0045766 10.3 VEGFA MIR21 IL1B FGF2 CXCL8
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 10.29 VEGFA TNF NGF IL6
13 cellular response to lipopolysaccharide GO:0071222 10.28 TNF MIR21 IL6 IL1B CXCL8
14 positive regulation of cell population proliferation GO:0008284 10.28 EGF FGF2 FGF7 FN1 IGF1 IL1B
15 positive regulation of endothelial cell proliferation GO:0001938 10.27 VEGFA PDGFB FGF7 FGF2 EGF
16 wound healing GO:0042060 10.24 INS IGF1 FN1 FGF2
17 protein kinase B signaling GO:0043491 10.24 TNF IL1B IGF1 FGF2
18 positive chemotaxis GO:0050918 10.23 VEGFA PDGFB FGF7 FGF2
19 positive regulation of osteoblast differentiation GO:0045669 10.22 FGF2 IGF1 IL6 MIR21
20 positive regulation of epithelial cell proliferation GO:0050679 10.22 EGF FGF2 FGF7 IGF1 VEGFA
21 acute-phase response GO:0006953 10.21 INS IL6 FN1 CRP
22 positive regulation of MAP kinase activity GO:0043406 10.21 EGF FGF2 IL1B PDGFB TNF VEGFA
23 positive regulation of blood vessel endothelial cell migration GO:0043536 10.2 VEGFA PDGFB FGF2
24 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.2 VEGFA TNF IL6 IGF1
25 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.2 VEGFA PDGFB IL6 IGF1 FGF7 EGF
26 positive regulation of MAPK cascade GO:0043410 10.2 VEGFA TNF PDGFB INS IL6 IGF1
27 positive regulation of endothelial cell migration GO:0010595 10.19 VEGFA MIR21 FGF2 EGF
28 positive regulation of DNA binding GO:0043388 10.19 NGF MMP9 IGF1 EGF
29 positive regulation of smooth muscle cell proliferation GO:0048661 10.19 FGF2 IGF1 IL6 PDGFB TNF
30 positive regulation of cell division GO:0051781 10.19 FGF2 FGF7 IL1B PDGFB VEGFA
31 positive regulation of protein kinase B signaling GO:0051897 10.18 VEGFA TNF MIR21 INS IGF1 FGF2
32 negative regulation of neurogenesis GO:0050768 10.17 TNF IL6 IL1B
33 positive regulation of protein autophosphorylation GO:0031954 10.16 VEGFA PDGFB INS
34 positive regulation of cytokine production GO:0001819 10.14 TNF MIR21 INS IL1B
35 negative regulation of lipid catabolic process GO:0050995 10.14 IL1B INS TNF
36 positive regulation of glial cell proliferation GO:0060252 10.14 IL1B IL6 TNF
37 activation of protein kinase B activity GO:0032148 10.13 PDGFB MIR21 INS IGF1
38 embryo implantation GO:0007566 10.12 MMP9 MIR21 IL1B
39 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.11 FGF2 IGF1 MIR21 MMP9 PDGFB TNF
40 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.09 IL6 MIR21 TNF
41 positive regulation of neuroinflammatory response GO:0150078 10.09 TNF IL6 IL1B
42 negative regulation of lipid storage GO:0010888 10.09 TNF IL6 CRP
43 vascular endothelial growth factor production GO:0010573 10.08 IL1B IL6 TNF
44 positive regulation of DNA biosynthetic process GO:2000573 10.07 VEGFA TNF PDGFB FGF2
45 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 10.03 TNF MIR21 IL6
46 positive regulation of fever generation GO:0031622 10.01 TNF IL1B
47 positive regulation of hyaluronan biosynthetic process GO:1900127 10.01 PDGFB EGF
48 sequestering of triglyceride GO:0030730 10.01 TNF IL1B
49 positive regulation of cerebellar granule cell precursor proliferation GO:0021940 10 FGF2 EGF
50 leukocyte migration GO:0050900 10 TNF MMP9 IL1B

Molecular functions related to Decubitus Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 10.32 VEGFA TTR TNF PDGFB MMP9 INS
2 heparin binding GO:0008201 9.96 VEGFA FN1 FGF7 FGF2 CXCL8
3 cytokine activity GO:0005125 9.9 CXCL8 FGF2 IL1B IL6 TNF VEGFA
4 chemoattractant activity GO:0042056 9.56 VEGFA PDGFB FGF7 FGF2
5 growth factor activity GO:0008083 9.53 VEGFA PDGFB NGF IL6 IGF1 FGF7

Sources for Decubitus Ulcer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....