DDLS
MCID: DDF001
MIFTS: 48

Dedifferentiated Liposarcoma (DDLS)

Categories: Rare diseases

Aliases & Classifications for Dedifferentiated Liposarcoma

MalaCards integrated aliases for Dedifferentiated Liposarcoma:

Name: Dedifferentiated Liposarcoma 59
Liposarcoma, Dedifferentiated 73
Liposarcoma Dedifferentiated 55
Ddls 59

Characteristics:

Orphanet epidemiological data:

59
dedifferentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 59 ORPHA99970
UMLS via Orphanet 74 C0205824
ICD10 via Orphanet 34 C49.9
UMLS 73 C0205824

Summaries for Dedifferentiated Liposarcoma

MalaCards based summary : Dedifferentiated Liposarcoma, also known as liposarcoma, dedifferentiated, is related to liposarcoma and hemangiopericytoma, malignant. An important gene associated with Dedifferentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include bone, colon and lung, and related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Dedifferentiated Liposarcoma

Diseases related to Dedifferentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 30.7 CDK4 CDKN2A DES HMGA2 MB MDM2
2 hemangiopericytoma, malignant 30.5 ACTC1 DES MDM2
3 histiocytoma 30.5 MB MDM2 TP53
4 malignant fibroxanthoma 30.4 ACTC1 CDK4 DES MDM2
5 well-differentiated liposarcoma 30.4 CDK4 CDKN2A HMGA2 MDM2
6 pleomorphic liposarcoma 30.3 CDKN2A DES MDM2
7 sarcoma 30.2 CDK4 MDM2 RB1 TP53
8 spindle cell sarcoma 30.1 ACTC1 DES MDM2
9 atypical lipomatous tumor 30.0 CDK4 CDKN2A HMGA2 MDM2
10 inflammatory myofibroblastic tumor 29.9 ACTC1 CDK4 DES MDM2 TP53
11 malignant peripheral nerve sheath tumor 29.7 ACTC1 CDK4 CDKN2A MDM2 TP53
12 myxoid liposarcoma 29.6 CDK4 HMGA2 IGF1R MDM2 TP53
13 leiomyosarcoma 29.6 ACTC1 CDK4 DES MB MDM2 TP53
14 rhabdomyosarcoma 29.4 ACTC1 CDK4 DES IGF1R MB MDM2
15 fibrous histiocytoma 10.3
16 peripheral osteosarcoma 10.3 CDK4 MDM2
17 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
18 adult medulloblastoma 10.2 MDM2 TP53
19 cellular myxoid liposarcoma 10.2 CDK4 MDM2
20 liver angiosarcoma 10.2 CDK4 TP53
21 inflammatory mfh 10.2 CDK4 MDM2
22 lipoblastoma 10.2 CDK4 MDM2
23 bone osteosarcoma 10.2 CDK4 MDM2
24 zika virus infection 10.2 MDM2 TP53
25 pre-malignant neoplasm 10.2 CDKN2A TP53
26 recessive dystrophic epidermolysis bullosa 10.2 CDKN2A TP53
27 vulva cancer 10.2 CDKN2A TP53
28 squamous cell papilloma 10.2 CDKN2A TP53
29 optic nerve neoplasm 10.2 CDKN2A TP53
30 juvenile pilocytic astrocytoma 10.2 CDKN2A TP53
31 laryngeal disease 10.2 CDKN2A TP53
32 barrett's adenocarcinoma 10.2 CDKN2A TP53
33 oropharynx cancer 10.2 CDKN2A TP53
34 tonsil cancer 10.2 CDKN2A TP53
35 chondroid lipoma 10.2 CDK4 MDM2
36 actinic cheilitis 10.2 MDM2 TP53
37 cheilitis 10.2 MDM2 TP53
38 cornea cancer 10.2 CDK4 CDKN2A
39 lip cancer 10.2 MDM2 TP53
40 spindle cell liposarcoma 10.2 CDK4 MDM2
41 angiolipoma 10.2 ACTC1 DES
42 ovarian fibrothecoma 10.2 ACTC1 DES
43 fibroblastic rheumatism 10.2 ACTC1 DES
44 granulosa cell tumor of the ovary 10.2 ACTC1 TP53
45 bladder squamous cell carcinoma 10.2 CDKN2A TP53
46 cutaneous leiomyosarcoma 10.2 ACTC1 DES
47 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
48 spitz nevus 10.2 CDKN2A TP53
49 glomangioma 10.2 ACTC1 DES
50 parachordoma 10.2 ACTC1 DES

Graphical network of the top 20 diseases related to Dedifferentiated Liposarcoma:



Diseases related to Dedifferentiated Liposarcoma

Symptoms & Phenotypes for Dedifferentiated Liposarcoma

GenomeRNAi Phenotypes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 9.13 TP53
2 Decreased CDKN1A mRNA expression GR00389-S-2 9.13 HMGA2 TP53
3 Increased TP53 mRNA expression GR00389-S-6 8.62 HMGA2 TP53

MGI Mouse Phenotypes related to Dedifferentiated Liposarcoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ACTC1 CDK4 CDKN2A DES IGF1R MB
2 cellular MP:0005384 10.19 ACTC1 CDK4 CDKN2A DES IGF1R MB
3 behavior/neurological MP:0005386 10.1 CDK4 CDKN2A DES IGF1R MDM2 RB1
4 homeostasis/metabolism MP:0005376 10.09 ACTC1 CDK4 CDKN2A DES IGF1R MB
5 growth/size/body region MP:0005378 10.08 ACTC1 CDK4 CDKN2A IGF1R MB MDM2
6 embryo MP:0005380 10.05 CDK4 CDKN2A IGF1R MB MDM2 RB1
7 digestive/alimentary MP:0005381 10 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
8 hematopoietic system MP:0005397 10 CDK4 CDKN2A IGF1R MB MDM2 RB1
9 endocrine/exocrine gland MP:0005379 9.97 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
10 mortality/aging MP:0010768 9.97 ACTC1 CDK4 CDKN2A DES IGF1R MB
11 muscle MP:0005369 9.91 ACTC1 CDK4 CDKN2A DES IGF1R MB
12 integument MP:0010771 9.88 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
13 liver/biliary system MP:0005370 9.85 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
14 neoplasm MP:0002006 9.63 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
15 pigmentation MP:0001186 9.35 CDK4 CDKN2A MDM2 RB1 TP53
16 reproductive system MP:0005389 9.1 CDK4 CDKN2A IGF1R MDM2 RB1 TP53

Drugs & Therapeutics for Dedifferentiated Liposarcoma

Search Clinical Trials , NIH Clinical Center for Dedifferentiated Liposarcoma

Genetic Tests for Dedifferentiated Liposarcoma

Anatomical Context for Dedifferentiated Liposarcoma

MalaCards organs/tissues related to Dedifferentiated Liposarcoma:

41
Bone, Colon, Lung, Kidney, Liver, Breast, Cervix

Publications for Dedifferentiated Liposarcoma

Articles related to Dedifferentiated Liposarcoma:

(show top 50) (show all 233)
# Title Authors Year
1
Dedifferentiated Liposarcoma Occurring in the Right Pulmonary Hilum. ( 29491279 )
2018
2
Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation Producing HCG: A Case Report of a Diagnostic Pitfall. ( 29532681 )
2018
3
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
4
Dedifferentiated liposarcoma of the oral floor: A case study and literature review of 50 cases of head and neck neoplasm. ( 29740489 )
2018
5
Whole blood miRNA expression analysis reveals miR-3613-3p as a potential biomarker for dedifferentiated liposarcoma. ( 29689704 )
2018
6
Giant Primary Retroperitoneal Dedifferentiated Liposarcoma. ( 29959642 )
2018
7
Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma. ( 29848707 )
2018
8
Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status. ( 29309298 )
2018
9
A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. ( 29446522 )
2018
10
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
11
Dedifferentiated liposarcoma composed predominantly of rhabdoid/epithelioid cells: a frequently misdiagnosed highly aggressive variant. ( 29307627 )
2018
12
Targeted next generation sequencing of well-differentiated/dedifferentiated liposarcoma reveals novel gene amplifications and mutations. ( 29731991 )
2018
13
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018
14
Recurrent paratesticular dedifferentiated liposarcoma after contralateral radical orchiectomy. ( 29623907 )
2018
15
miR-133a function in the pathogenesis of dedifferentiated liposarcoma. ( 29983640 )
2018
16
Dedifferentiated liposarcoma of the spermatic cord with features of epithelioid rhabdomyosarcoma and a rapidly fatal outcome. ( 30094897 )
2018
17
An unusual case of recurrent huge primary mediastinal dedifferentiated liposarcoma. ( 30121443 )
2018
18
Spinal Metastasis of Well-Differentiated Liposarcoma Component in Retroperitoneal Dedifferentiated Liposarcoma Treated by Minimally Invasive Surgery. ( 30123596 )
2018
19
Dedifferentiated liposarcoma of the left kidney: A rare case report. ( 30140614 )
2018
20
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. ( 30249211 )
2018
21
Cardiac Dedifferentiated Liposarcoma Requiring a Mitral Valve Replacement Complicated by Severe Paravalvular Leak: A Rare Case Report with Literature Review. ( 30254766 )
2018
22
Dedifferentiated Liposarcoma With Myofibroblastic Differentiation. ( 30281365 )
2018
23
Massive retroperitoneal dedifferentiated liposarcoma in a young patient. ( 30310651 )
2018
24
Primary mediastinal dedifferentiated liposarcoma: Five case reports and a review. ( 30329218 )
2018
25
Primary anatomical site, adjuvant therapy, and other prognostic variables for dedifferentiated liposarcoma. ( 30361927 )
2018
26
Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma. ( 30392912 )
2018
27
Retroperitoneal dedifferentiated liposarcoma: Analysis of 61 cases from a large institution. ( 30410585 )
2018
28
Dedifferentiated liposarcoma of the gallbladder: first reported case. ( 30419915 )
2018
29
Amplification of DNA damage-inducible transcript 3 (DDIT3) is associated with myxoid liposarcoma-like morphology and homologous lipoblastic differentiation in dedifferentiated liposarcoma. ( 30420727 )
2018
30
Retroperitoneal dedifferentiated liposarcoma. ( 30519920 )
2018
31
Giant retroperitoneal dedifferentiated liposarcoma. ( 28098568 )
2017
32
Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard. ( 28928422 )
2017
33
A retroperitoneal dedifferentiated liposarcoma mimicking an ovarian tumor. ( 29184870 )
2017
34
Retroperitoneal dedifferentiated liposarcoma with huge cystic degeneration: A case report. ( 28337832 )
2017
35
Identification of key genes and molecular mechanisms associated with dedifferentiated liposarcoma based on bioinformatic methods. ( 28670134 )
2017
36
Primary colonic well-differentiatedA /A dedifferentiated liposarcoma of the ascending colon: a case report. ( 28856628 )
2017
37
A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. ( 29046788 )
2017
38
Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology. ( 28193096 )
2017
39
Systemic Therapy in Metastatic or Unresectable Well-Differentiated/Dedifferentiated Liposarcoma. ( 29250486 )
2017
40
An unusual case of primary colonic dedifferentiated liposarcoma with confusing presentation. ( 29492941 )
2017
41
Atypical lipomatous tumor of the hand with transformation to dedifferentiated liposarcoma: a case report. ( 29209735 )
2017
42
Preoperative Radiation Therapy With Simultaneous Integrated Boost Dose Escalation for Optimal Local Control of Retroperitoneal Dedifferentiated Liposarcoma. ( 28463146 )
2017
43
Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. ( 28099935 )
2017
44
Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification. ( 29076540 )
2017
45
High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. ( 29153098 )
2017
46
Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features. ( 28719466 )
2017
47
Malignant solitary fibrous tumour of the kidney with lymph node and liver metastases: beware of STAT6 expression in dedifferentiated liposarcoma with a solitary fibrous tumour-like morphology: author reply. ( 28838615 )
2017
48
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma. ( 28552535 )
2017
49
Mediastinal dedifferentiated liposarcoma. ( 28707566 )
2017
50
A case of dedifferentiated liposarcoma of the heart and stomach. ( 29031176 )
2017

Variations for Dedifferentiated Liposarcoma

Expression for Dedifferentiated Liposarcoma

Search GEO for disease gene expression data for Dedifferentiated Liposarcoma.

Pathways for Dedifferentiated Liposarcoma

Pathways related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 CDK4 CDKN2A DES IGF1R MDM2 RB1
2
Show member pathways
13.56 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
3
Show member pathways
13.02 CDK4 CDKN2A HMGA2 MDM2 RB1 TP53
4
Show member pathways
12.96 CDK4 CDKN2A MDM2 RB1 TP53
5
Show member pathways
12.91 CDK4 IGF1R MDM2 RB1 TP53
6
Show member pathways
12.75 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
7
Show member pathways
12.7 CDKN2A IGF1R MDM2 TP53
8 12.69 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
9
Show member pathways
12.68 CDK4 CDKN2A IGF1R RB1 TP53
10
Show member pathways
12.61 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
11
Show member pathways
12.6 CDK4 MDM2 RB1 TP53
12
Show member pathways
12.49 CDK4 CDKN2A MDM2 RB1 TP53
13 12.45 CDKN2A HMGA2 MDM2 TP53
14 12.43 CDK4 CDKN2A MDM2 RB1 TP53
15 12.36 CDK4 CDKN2A RB1 TP53
16
Show member pathways
12.3 CDK4 CDKN2A RB1 TP53
17
Show member pathways
12.28 CDK4 CDKN2A MDM2 RB1 TP53
18 12.24 CDK4 MDM2 RB1 TP53
19
Show member pathways
12.23 HMGA2 RB1 TP53
20 12.23 CDK4 CDKN2A MDM2 RB1 TP53
21 12.2 HMGA2 IGF1R MDM2 TP53
22
Show member pathways
12.19 CDK4 MDM2 RB1 TP53
23 12.18 IGF1R MDM2 TP53
24 12.13 CDK4 CDKN2A MDM2 RB1 TP53
25
Show member pathways
12.12 CDK4 CDKN2A RB1
26
Show member pathways
12.12 CDK4 IGF1R MDM2 RB1 TP53
27 12.08 CDK4 IGF1R MDM2 TP53
28 12.07 CDK4 MDM2 RB1 TP53
29 12.01 CDK4 CDKN2A MDM2 RB1 TP53
30 11.99 CDKN2A MDM2 RB1 TP53
31 11.98 MDM2 RB1 TP53
32 11.94 CDK4 RB1 TP53
33 11.92 CDKN2A MDM2 TP53
34 11.82 CDK4 RB1 TP53
35 11.79 CDK4 MDM2 RB1 TP53
36 11.71 CDKN2A MDM2 TP53
37
Show member pathways
11.7 CDKN2A MDM2 TP53
38 11.68 CDKN2A IGF1R MDM2 RB1 TP53
39 11.67 CDK4 IGF1R RB1
40 11.63 CDKN2A MDM2 RB1 TP53
41 11.56 CDKN2A MDM2 TP53
42 11.53 CDKN2A RB1 TP53
43 11.45 CDK4 MDM2 TP53
44 11.33 CDK4 MDM2 RB1 TP53
45 11.28 CDK4 RB1
46 11.22 CDK4 CDKN2A MDM2 RB1 TP53
47 11.21 CDK4 TP53
48 11.19 MDM2 TP53
49 11.15 CDK4 CDKN2A IGF1R MDM2 RB1 TP53
50 11.13 CDK4 CDKN2A MDM2 TP53

GO Terms for Dedifferentiated Liposarcoma

Cellular components related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.13 CDK4 HMGA2 RB1
2 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.91 CDKN2A HMGA2 RB1 TP53
2 positive regulation of apoptotic process GO:0043065 9.81 CDK4 CDKN2A HMGA2 TP53
3 cell cycle GO:0007049 9.8 CDK4 CDKN2A HMGA2 RB1 TP53
4 cell cycle arrest GO:0007050 9.72 CDKN2A RB1 TP53
5 negative regulation of apoptotic process GO:0043066 9.72 ACTC1 HMGA2 IGF1R MDM2 TP53
6 G1/S transition of mitotic cell cycle GO:0000082 9.67 CDK4 CDKN2A RB1
7 negative regulation of transcription, DNA-templated GO:0045892 9.65 CDKN2A HMGA2 MDM2 RB1 TP53
8 protein tetramerization GO:0051262 9.61 IGF1R TP53
9 Ras protein signal transduction GO:0007265 9.61 CDKN2A RB1 TP53
10 response to antibiotic GO:0046677 9.6 MDM2 TP53
11 cellular response to gamma radiation GO:0071480 9.59 MDM2 TP53
12 positive regulation of cell cycle arrest GO:0071158 9.58 HMGA2 TP53
13 negative regulation of cell cycle arrest GO:0071157 9.58 CDK4 MDM2
14 positive regulation of protein export from nucleus GO:0046827 9.57 MDM2 TP53
15 positive regulation of cellular senescence GO:2000774 9.56 CDKN2A HMGA2
16 positive regulation of transcription regulatory region DNA binding GO:2000679 9.54 HMGA2 RB1
17 replicative senescence GO:0090399 9.52 CDKN2A TP53
18 amyloid fibril formation GO:1990000 9.48 CDKN2A MDM2
19 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.46 CDK4 CDKN2A
20 enucleate erythrocyte differentiation GO:0043353 9.37 MB RB1
21 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
22 positive regulation of gene expression GO:0010628 9.02 ACTC1 CDKN2A HMGA2 MDM2 TP53
23 senescence-associated heterochromatin focus assembly GO:0035986 8.96 CDKN2A HMGA2

Molecular functions related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 DES IGF1R MDM2 RB1 TP53
2 SUMO transferase activity GO:0019789 9.26 CDKN2A MDM2
3 transcription factor binding GO:0008134 9.26 CDKN2A HMGA2 RB1 TP53
4 disordered domain specific binding GO:0097718 8.92 CDKN2A MDM2 RB1 TP53

Sources for Dedifferentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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