MCID: DDF001
MIFTS: 47

Dedifferentiated Liposarcoma

Categories: Rare diseases

Aliases & Classifications for Dedifferentiated Liposarcoma

MalaCards integrated aliases for Dedifferentiated Liposarcoma:

Name: Dedifferentiated Liposarcoma 59
Liposarcoma, Dedifferentiated 73
Liposarcoma Dedifferentiated 55
Ddls 59

Characteristics:

Orphanet epidemiological data:

59
dedifferentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 59 ORPHA99970
UMLS via Orphanet 74 C0205824
ICD10 via Orphanet 34 C49.9
UMLS 73 C0205824

Summaries for Dedifferentiated Liposarcoma

MalaCards based summary : Dedifferentiated Liposarcoma, also known as liposarcoma, dedifferentiated, is related to histiocytoma and hemangiopericytoma, malignant. An important gene associated with Dedifferentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are ERK Signaling and Cell Cycle, Mitotic. The drugs Rosiglitazone and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and testes, and related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Dedifferentiated Liposarcoma

Diseases related to Dedifferentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 30.6 CDK4 MDM2 TP53
2 hemangiopericytoma, malignant 29.5 ACTC1 DES MDM2 MUC1
3 inflammatory myofibroblastic tumor 29.4 ACTC1 DES MDM2 TP53
4 atypical lipomatous tumor 29.1 CDK4 CDKN2A HMGA2 MDM2
5 leiomyosarcoma 29.0 ACTC1 CDK4 DES MDM2 TP53
6 malignant fibroxanthoma 29.0 ACTC1 CDK4 DES MDM2 MUC1
7 liposarcoma 29.0 CDK4 CDKN2A DES HMGA2 MDM2 TP53
8 rhabdomyosarcoma 28.8 ACTC1 CDK4 DES MDM2 TP53
9 myxoid liposarcoma 28.6 CDK4 HMGA2 MDM2 TP53
10 pleomorphic liposarcoma 28.5 ACTC1 CDKN2A DES MDM2 MUC1
11 well-differentiated liposarcoma 28.3 CDK4 CDKN2A HMGA2 MDM2 MUC1
12 malignant peripheral nerve sheath tumor 27.4 ACTC1 CDK4 CDKN2A MDM2 MUC1 TP53
13 undifferentiated embryonal sarcoma of the liver 10.8 CDK4 MDM2
14 extraosseous osteosarcoma 10.8 CDK4 MDM2
15 inflammatory mfh 10.8 CDK4 MDM2
16 bone osteosarcoma 10.8 CDK4 MDM2
17 lipoblastoma 10.8 CDK4 MDM2
18 mixed liposarcoma 10.7 CDK4 MDM2
19 spindle cell liposarcoma 10.7 CDK4 MDM2
20 chondroid lipoma 10.7 CDK4 MDM2
21 juxtacortical osteosarcoma 10.7 CDK4 MDM2
22 ovarian fibrothecoma 10.6 ACTC1 DES
23 fibroblastic rheumatism 10.6 ACTC1 DES
24 angiolipoma 10.6 ACTC1 DES
25 zika virus infection 10.6 MDM2 TP53
26 botryoid rhabdomyosarcoma 10.6 ACTC1 DES
27 epithelioid leiomyosarcoma 10.6 ACTC1 DES
28 actinic cheilitis 10.6 MDM2 TP53
29 benign metastasizing leiomyoma 10.6 ACTC1 DES
30 sclerosing liposarcoma 10.6 MDM2 TP53
31 lip cancer 10.6 MDM2 TP53
32 congenital fibrosarcoma 10.5 ACTC1 DES
33 pulmonary vein stenosis 10.5 ACTC1 DES
34 bizarre leiomyoma 10.5 ACTC1 CDKN2A
35 cystic nephroma 10.5 ACTC1 DES
36 peripheral osteosarcoma 10.5 CDK4 MDM2
37 cutaneous fibrous histiocytoma 10.5 ACTC1 DES
38 brain stem astrocytic neoplasm 10.5 CDKN2A TP53
39 bilateral retinoblastoma 10.5 DES RB1
40 non-langerhans-cell histiocytosis 10.5 ACTC1 DES
41 gliomatosis cerebri 10.5 MDM2 TP53
42 pseudosarcomatous fibromatosis 10.5 ACTC1 DES
43 soft tissue sarcoma 10.5 MDM2 TP53
44 keratinizing squamous cell carcinoma 10.5 CDKN2A TP53
45 gallbladder adenoma 10.5 CDKN2A RB1
46 spitz nevus 10.5 CDKN2A TP53
47 bladder carcinoma in situ 10.4 CDKN2A TP53
48 bartholin's gland benign neoplasm 10.4 CDKN2A TP53
49 vulva squamous cell carcinoma 10.4 CDKN2A TP53
50 thyroid lymphoma 10.4 CDKN2A TP53

Graphical network of the top 20 diseases related to Dedifferentiated Liposarcoma:



Diseases related to Dedifferentiated Liposarcoma

Symptoms & Phenotypes for Dedifferentiated Liposarcoma

GenomeRNAi Phenotypes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 9.13 TP53
2 Decreased CDKN1A mRNA expression GR00389-S-2 9.13 HMGA2 TP53
3 Increased TP53 mRNA expression GR00389-S-6 8.62 HMGA2 TP53

MGI Mouse Phenotypes related to Dedifferentiated Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 ACTC1 CDK4 CDKN2A DES MDM2 RB1
2 cellular MP:0005384 9.91 ACTC1 CDK4 CDKN2A DES MDM2 RB1
3 digestive/alimentary MP:0005381 9.72 CDK4 CDKN2A MDM2 RB1 TP53
4 muscle MP:0005369 9.7 MDM2 RB1 TP53 ACTC1 CDK4 CDKN2A
5 liver/biliary system MP:0005370 9.65 CDKN2A MDM2 RB1 TP53 CDK4
6 neoplasm MP:0002006 9.35 CDK4 CDKN2A MDM2 RB1 TP53
7 pigmentation MP:0001186 9.02 CDK4 CDKN2A MDM2 RB1 TP53

Drugs & Therapeutics for Dedifferentiated Liposarcoma

Drugs for Dedifferentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
2
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
3
Ifosfamide Approved Phase 2 3778-73-2 3690
4
Mesna Approved, Investigational Phase 2 3375-50-6 598
5
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
6
Everolimus Approved Phase 2 159351-69-6 6442177
7
Pembrolizumab Approved Phase 2 1374853-91-4
8
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
9
nivolumab Approved Phase 2 946414-94-4
10
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
11
Maleic acid Experimental Phase 2 110-16-7 444266
12 Hypoglycemic Agents Phase 2
13
Isophosphamide mustard Phase 2 0
14 Alkylating Agents Phase 2
15 Anti-Bacterial Agents Phase 2
16 Antibiotics, Antitubercular Phase 2
17 Antibodies Phase 2
18 Immunoglobulins Phase 2
19 Antibodies, Monoclonal Phase 2
20 Immunosuppressive Agents Phase 2
21 Anti-Infective Agents Phase 2
22 Antifungal Agents Phase 2
23 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Selinexor in Advanced Liposarcoma Recruiting NCT02606461 Phase 2, Phase 3 Selinexor;Placebo
2 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Unknown status NCT01692496 Phase 2 Pazopanib
3 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
4 Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) Recruiting NCT03114527 Phase 2 Ribociclib;Everolimus
5 Study of Abemaciclib in Dedifferentiated Liposarcoma Recruiting NCT02846987 Phase 2 Abemaciclib
6 Ph II Cabazitaxel DD Liposarcoma Recruiting NCT01913652 Phase 2 Cabazitaxel
7 A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Recruiting NCT03096912 Phase 2 Ribociclib
8 Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma Recruiting NCT02247544 Phase 2 Trabectedin
9 Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting NCT03307616 Phase 2 Nivolumab;Ipilimumab
10 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2 Pembrolizumab
11 Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery Recruiting NCT02500797 Phase 2
12 A Phase II Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Active, not recruiting NCT02571829 Phase 2 ribociclib
13 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
14 Study Evaluating the Efficacy and Safety of IPI 504 in Patients With Advanced Dedifferentiated Liposarcoma Withdrawn NCT00969917 Phase 2 IPI-504
15 Phase 1 Safety Testing of SAR405838 Completed NCT01636479 Phase 1 SAR405838
16 The FGF/FGFR Signalling Pathway: Recruiting NCT03303885

Search NIH Clinical Center for Dedifferentiated Liposarcoma

Genetic Tests for Dedifferentiated Liposarcoma

Anatomical Context for Dedifferentiated Liposarcoma

MalaCards organs/tissues related to Dedifferentiated Liposarcoma:

41
Bone, Colon, Testes, Lung, Liver, Lymph Node, Kidney

Publications for Dedifferentiated Liposarcoma

Articles related to Dedifferentiated Liposarcoma:

(show top 50) (show all 227)
# Title Authors Year
1
Dedifferentiated Liposarcoma Occurring in the Right Pulmonary Hilum. ( 29491279 )
2018
2
Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation Producing HCG: A Case Report of a Diagnostic Pitfall. ( 29532681 )
2018
3
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
4
Dedifferentiated liposarcoma of the oral floor: A case study and literature review of 50 cases of head and neck neoplasm. ( 29740489 )
2018
5
Whole blood miRNA expression analysis reveals miR-3613-3p as a potential biomarker for dedifferentiated liposarcoma. ( 29689704 )
2018
6
Giant Primary Retroperitoneal Dedifferentiated Liposarcoma. ( 29959642 )
2018
7
Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma. ( 29848707 )
2018
8
Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status. ( 29309298 )
2018
9
A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. ( 29446522 )
2018
10
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
11
Dedifferentiated liposarcoma composed predominantly of rhabdoid/epithelioid cells: a frequently misdiagnosed highly aggressive variant. ( 29307627 )
2018
12
Targeted next generation sequencing of well-differentiated/dedifferentiated liposarcoma reveals novel gene amplifications and mutations. ( 29731991 )
2018
13
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018
14
Recurrent paratesticular dedifferentiated liposarcoma after contralateral radical orchiectomy. ( 29623907 )
2018
15
Giant retroperitoneal dedifferentiated liposarcoma. ( 28098568 )
2017
16
Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard. ( 28928422 )
2017
17
A retroperitoneal dedifferentiated liposarcoma mimicking an ovarian tumor. ( 29184870 )
2017
18
Retroperitoneal dedifferentiated liposarcoma with huge cystic degeneration: A case report. ( 28337832 )
2017
19
Identification of key genes and molecular mechanisms associated with dedifferentiated liposarcoma based on bioinformatic methods. ( 28670134 )
2017
20
Primary colonic well-differentiatedA /A dedifferentiated liposarcoma of the ascending colon: a case report. ( 28856628 )
2017
21
A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. ( 29046788 )
2017
22
Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology. ( 28193096 )
2017
23
p16 Immunohistochemistry is Less Useful Than MDM2 and CDK4 to Distinguish Dedifferentiated Liposarcomas From Other Retroperitoneal Mimics. ( 26509911 )
2017
24
Systemic Therapy in Metastatic or Unresectable Well-Differentiated/Dedifferentiated Liposarcoma. ( 29250486 )
2017
25
An unusual case of primary colonic dedifferentiated liposarcoma with confusing presentation. ( 29492941 )
2017
26
Atypical lipomatous tumor of the hand with transformation to dedifferentiated liposarcoma: a case report. ( 29209735 )
2017
27
Preoperative Radiation Therapy With Simultaneous Integrated Boost Dose Escalation for Optimal Local Control of Retroperitoneal Dedifferentiated Liposarcoma. ( 28463146 )
2017
28
Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. ( 28099935 )
2017
29
Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification. ( 29076540 )
2017
30
High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. ( 29153098 )
2017
31
Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features. ( 28719466 )
2017
32
Malignant solitary fibrous tumour of the kidney with lymph node and liver metastases: beware of STAT6 expression in dedifferentiated liposarcoma with a solitary fibrous tumour-like morphology: author reply. ( 28838615 )
2017
33
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma. ( 28552535 )
2017
34
Mediastinal dedifferentiated liposarcoma. ( 28707566 )
2017
35
A case of dedifferentiated liposarcoma of the heart and stomach. ( 29031176 )
2017
36
Malignant solitary fibrous tumour of the kidney with lymph node and liver metastases: beware of STAT6 expression in dedifferentiated liposarcoma with a solitary fibrous tumour-like morphology. ( 28822554 )
2017
37
Scattered genomic amplification in dedifferentiated liposarcoma. ( 28652867 )
2017
38
Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass. ( 28950740 )
2017
39
Dedifferentiated Liposarcoma in the Spermatic Cord Finally Diagnosed at 7th Resection of Recurrence: A Case Report and Bibliographic Consideration. ( 28878655 )
2017
40
Dedifferentiated liposarcoma of the lower extremity with low-grade dedifferentiation and low-grade osteosarcomatous component. ( 27909788 )
2017
41
Multiple Primary Dedifferentiated Liposarcoma of the Jejunal Mesentery: A Case Report and Review of Literature. ( 26894164 )
2016
42
Dedifferentiated Liposarcoma of the Esophagus: A Case Report and Selected Review of the Literature. ( 28191296 )
2016
43
MDM2 Expression in Extranodal Abdominal and Retroperitoneal Follicular Dendritic Cell Sarcomas, Mimicking Dedifferentiated Liposarcomas. ( 26180935 )
2016
44
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. ( 27597521 )
2016
45
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma. ( 27409346 )
2016
46
Plasma levels of miRNA-155 as a powerful diagnostic marker for dedifferentiated liposarcoma. ( 27186423 )
2016
47
Primary mediastinal dedifferentiated liposarcoma resected by lateral thoracotomy with video-assisted thoracoscopic surgery. ( 26724326 )
2016
48
Rare Aggressive Behavior of MDM2-Amplified Retroperitoneal Dedifferentiated Liposarcoma, with Brain, Lung and Subcutaneous Metastases. ( 27746879 )
2016
49
Dedifferentiated Liposarcoma: Updates on Morphology, Genetics, and Therapeutic Strategies. ( 26645460 )
2016
50
Dedifferentiated Liposarcoma of Sigmoid Mesocolon - A Case Report. ( 27604671 )
2016

Variations for Dedifferentiated Liposarcoma

Expression for Dedifferentiated Liposarcoma

Search GEO for disease gene expression data for Dedifferentiated Liposarcoma.

Pathways for Dedifferentiated Liposarcoma

Pathways related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 CDK4 CDKN2A DES MDM2 MUC1 RB1
2
Show member pathways
13.26 CDK4 CDKN2A MDM2 RB1 TP53
3
Show member pathways
12.97 CDK4 CDKN2A HMGA2 MDM2 RB1 TP53
4
Show member pathways
12.86 ACTC1 CDK4 CDKN2A RB1
5
Show member pathways
12.82 CDK4 MDM2 RB1 TP53
6
Show member pathways
12.75 CDK4 CDKN2A MDM2 RB1 TP53
7 12.72 CDK4 CDKN2A MDM2 RB1 TP53
8
Show member pathways
12.64 CDK4 CDKN2A RB1 TP53
9
Show member pathways
12.63 CDK4 CDKN2A MDM2 RB1 TP53
10
Show member pathways
12.58 CDK4 MDM2 RB1 TP53
11
Show member pathways
12.44 CDK4 CDKN2A MDM2 RB1 TP53
12
Show member pathways
12.43 MDM2 MUC1 RB1 TP53
13 12.42 CDKN2A HMGA2 MDM2 TP53
14 12.36 CDK4 CDKN2A MDM2 RB1 TP53
15 12.34 CDK4 CDKN2A RB1 TP53
16
Show member pathways
12.29 CDK4 DES RB1
17
Show member pathways
12.27 CDK4 CDKN2A RB1 TP53
18
Show member pathways
12.22 CDK4 CDKN2A MDM2 RB1 TP53
19
Show member pathways
12.21 HMGA2 RB1 TP53
20 12.19 CDK4 CDKN2A MDM2 RB1 TP53
21 12.16 MDM2 RB1 TP53
22
Show member pathways
12.16 CDK4 MDM2 RB1 TP53
23 12.12 HMGA2 MDM2 TP53
24 12.11 CDK4 CDKN2A MDM2 RB1 TP53
25
Show member pathways
12.1 CDK4 CDKN2A RB1
26 12.05 CDK4 MDM2 RB1 TP53
27 12.02 CDK4 MDM2 TP53
28 11.96 MDM2 RB1 TP53
29 11.96 CDKN2A MDM2 RB1 TP53
30 11.92 CDK4 CDKN2A MDM2 RB1 TP53
31 11.91 CDK4 RB1 TP53
32 11.89 CDKN2A MDM2 TP53
33 11.84 CDKN2A MDM2 RB1 TP53
34 11.8 CDK4 RB1 TP53
35 11.72 CDK4 MDM2 RB1 TP53
36 11.68 CDKN2A MDM2 TP53
37
Show member pathways
11.67 CDKN2A MDM2 TP53
38 11.6 CDK4 CDKN2A MDM2 RB1 TP53
39 11.53 CDKN2A MDM2 TP53
40 11.49 CDKN2A RB1 TP53
41 11.41 CDK4 MDM2 TP53
42 11.33 CDK4 MDM2 RB1 TP53
43 11.27 CDK4 RB1
44 11.2 CDK4 TP53
45 11.18 MDM2 TP53
46 11.06 CDK4 CDKN2A MDM2 TP53
47
Show member pathways
11.05 CDKN2A MDM2 TP53
48 10.88 CDK4 CDKN2A MDM2 RB1 TP53
49 10.6 CDKN2A MDM2 RB1 TP53

GO Terms for Dedifferentiated Liposarcoma

Cellular components related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.13 CDK4 HMGA2 RB1
2 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.89 CDKN2A HMGA2 RB1 TP53
2 negative regulation of apoptotic process GO:0043066 9.88 ACTC1 HMGA2 MDM2 TP53
3 positive regulation of apoptotic process GO:0043065 9.78 CDK4 CDKN2A HMGA2 TP53
4 cell cycle GO:0007049 9.77 CDK4 CDKN2A HMGA2 RB1 TP53
5 cell cycle arrest GO:0007050 9.72 CDKN2A RB1 TP53
6 G1/S transition of mitotic cell cycle GO:0000082 9.67 CDK4 CDKN2A RB1
7 negative regulation of transcription, DNA-templated GO:0045892 9.65 CDKN2A HMGA2 MDM2 RB1 TP53
8 base-excision repair GO:0006284 9.62 HMGA2 TP53
9 muscle filament sliding GO:0030049 9.62 ACTC1 DES
10 response to antibiotic GO:0046677 9.61 MDM2 TP53
11 positive regulation of cell cycle arrest GO:0071158 9.61 HMGA2 TP53
12 cellular response to gamma radiation GO:0071480 9.6 MDM2 TP53
13 negative regulation of cell cycle arrest GO:0071157 9.58 CDK4 MDM2
14 Ras protein signal transduction GO:0007265 9.58 CDKN2A RB1 TP53
15 positive regulation of protein export from nucleus GO:0046827 9.57 MDM2 TP53
16 positive regulation of cellular senescence GO:2000774 9.56 CDKN2A HMGA2
17 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.54 MUC1 TP53
18 positive regulation of transcription regulatory region DNA binding GO:2000679 9.52 HMGA2 RB1
19 replicative senescence GO:0090399 9.51 CDKN2A TP53
20 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 MDM2 MUC1 TP53
21 amyloid fibril formation GO:1990000 9.46 CDKN2A MDM2
22 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.43 CDK4 CDKN2A
23 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
24 positive regulation of gene expression GO:0010628 9.02 ACTC1 CDKN2A HMGA2 MDM2 TP53
25 senescence-associated heterochromatin focus assembly GO:0035986 8.96 CDKN2A HMGA2

Molecular functions related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.56 HMGA2 MDM2 RB1 TP53
2 transcription factor binding GO:0008134 9.46 CDKN2A HMGA2 RB1 TP53
3 SUMO transferase activity GO:0019789 9.32 CDKN2A MDM2
4 p53 binding GO:0002039 9.13 MDM2 MUC1 TP53
5 disordered domain specific binding GO:0097718 8.92 CDKN2A MDM2 RB1 TP53

Sources for Dedifferentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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