MCID: DPK001
MIFTS: 19

Deep Keratitis

Categories: Neuronal diseases

Aliases & Classifications for Deep Keratitis

MalaCards integrated aliases for Deep Keratitis:

Name: Deep Keratitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9858
ICD9CM 34 370.5
SNOMED-CT 67 193783008
ICD10 32 H16.3
UMLS 70 C0155087 C2960633

Summaries for Deep Keratitis

MalaCards based summary : Deep Keratitis is related to sclerosing keratitis and keratitis, hereditary. An important gene associated with Deep Keratitis is PRTN3 (Proteinase 3). Affiliated tissues include eye.

Related Diseases for Deep Keratitis

Diseases related to Deep Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 sclerosing keratitis 30.8 SPESP1 RBP3 PRTN3 IL2 GLS2
2 keratitis, hereditary 10.3
3 endocardium disease 10.2 SPESP1 PRTN3
4 anca-associated vasculitis 10.2 PRTN3 IL2
5 splenic tuberculosis 10.2 PRTN3 IL2
6 cogan syndrome 10.2
7 herpes simplex virus stromal keratitis 10.2
8 idiopathic linear interstitial keratitis 10.2
9 autoimmune vasculitis 10.2 PRTN3 IL2
10 central nervous system vasculitis 10.2 PRTN3 IL2
11 impetigo herpetiformis 10.1 PRTN3 PI3
12 impetigo 10.1 PRTN3 PI3
13 autoimmune disease of blood 10.1 PRTN3 IL2
14 churg-strauss syndrome 10.1 PRTN3 IL2
15 autoimmune disease of cardiovascular system 10.1 PRTN3 IL2
16 chorioretinitis 10.1 RBP3 IL2
17 pars planitis 10.1 RBP3 IL2
18 nose disease 10.1 PRTN3 IL2
19 autoimmune disease of eyes, ear, nose and throat 10.1 RBP3 IL2
20 exanthem 10.1 PRTN3 IL2
21 hypersensitivity reaction type iv disease 10.1 PRTN3 IL2
22 posterior uveitis 10.1 RBP3 IL2
23 onchocerciasis 10.1 RBP3 IL2
24 limited scleroderma 10.0 PRTN3 IL2
25 erysipelas 10.0 PI3 IL2
26 temporal arteritis 10.0 PRTN3 IL2
27 autoimmune uveitis 10.0 RBP3 IL2
28 balanoposthitis 10.0 SLPI IL2
29 trichomoniasis 10.0 SLPI IL2
30 systemic lupus erythematosus 10.0
31 lupus erythematosus 10.0
32 pustular psoriasis 10.0 SLPI PI3
33 vaginal disease 10.0 SLPI IL2
34 scleral disease 10.0 RBP3 PRTN3 IL2
35 pasteurellosis 10.0 SLPI PI3
36 anus disease 10.0 SLPI IL2
37 uveal disease 10.0 RBP3 IL2
38 behcet syndrome 9.9 RBP3 PRTN3 IL2
39 rectal disease 9.9 SLPI IL2
40 alpha-1-antitrypsin deficiency 9.9 SLPI PRTN3
41 corneal edema 9.8
42 superficial keratitis 9.8
43 iritis 9.8
44 corneal ulcer 9.8
45 herpes simplex 9.8
46 lichen planus 9.8
47 iridocyclitis 9.8
48 gingivitis 9.8 SLPI IL2
49 lymphoid interstitial pneumonia 9.8 PRTN3 IL2
50 pulmonary disease, chronic obstructive 9.8 SLPI PRTN3 PI3

Graphical network of the top 20 diseases related to Deep Keratitis:



Diseases related to Deep Keratitis

Symptoms & Phenotypes for Deep Keratitis

Drugs & Therapeutics for Deep Keratitis

Search Clinical Trials , NIH Clinical Center for Deep Keratitis

Genetic Tests for Deep Keratitis

Anatomical Context for Deep Keratitis

MalaCards organs/tissues related to Deep Keratitis:

40
Eye

Publications for Deep Keratitis

Articles related to Deep Keratitis:

(show all 16)
# Title Authors PMID Year
1
Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization. 61
31040672 2019
2
Medical management of suspected Paecilomyces sp. deep keratitis. 61
26135494 2015
3
Topical 5% Natamycin With Oral Ketoconazole in Filamentous Fungal Keratitis: A Randomized Controlled Trial. 61
26065500 2015
4
Bilateral deep keratitis caused by systemic lupus erythematosus. 61
15075893 2004
5
Fungal infection of sutureless self-sealing incision for cataract surgery. 61
14597526 2003
6
[Superficial amebic keratitis]. 61
8496566 1993
7
[The clinical case. Corneal ulcer, superficial and deep keratitis and acute iritis]. 61
2617521 1989
8
Application of immunoperoxidase staining in the cytodiagnosis of herpes simplex keratitis. 61
2424687 1985
9
[Pathogenicity of herpes simplex virus-I in causing deep keratitis]. 61
6327205 1983
10
[The effects of topical steroids in epidemic kerato-conjunctivitis (author's transl)]. 61
6256579 1980
11
[From superficial keratitis to deep keratitis: considerations on metaherpetic keratitis]. 61
6258675 1980
12
A therapeutic evaluation to the pathogeneses of deep keratitis of obscure origin. 61
4666763 1972
13
Deep keratitis of obscure origin. 61
5744605 1968
14
[The pathogenesis of herpetic, deep keratitis and uveokeratitis]. 61
5630159 1967
15
BILATERAL BAND-SHAPED DEEP KERATITIS AND IRIDOCYCLITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS. 61
18170862 1964
16
Deep keratitis associated with atypical lichen planus; report of a case. 61
18106939 1948

Variations for Deep Keratitis

Expression for Deep Keratitis

Search GEO for disease gene expression data for Deep Keratitis.

Pathways for Deep Keratitis

GO Terms for Deep Keratitis

Cellular components related to Deep Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 SLPI SCGB1D1 RBP3 PRTN3 PI3 IL2
2 extracellular space GO:0005615 9.1 SLPI SCGB1D1 RBP3 PRTN3 PI3 IL2

Biological processes related to Deep Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 8.96 PRTN3 PI3
2 antibacterial humoral response GO:0019731 8.62 SLPI PI3

Molecular functions related to Deep Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 SLPI PI3

Sources for Deep Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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