Deep Leiomyoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Deep Leiomyoma

MalaCards integrated aliases for Deep Leiomyoma:

Name: Deep Leiomyoma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5128

NCIt ⁵⁰ C6512

UMLS ⁷⁰ C1333266

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Summaries for Deep Leiomyoma

Disease Ontology : ¹² A leiomyoma that is located in deep soft tissue.

MalaCards based summary : Deep Leiomyoma is related to leiomyoma and esophageal adenoid cystic carcinoma. An important gene associated with Deep Leiomyoma is CD177 (CD177 Molecule), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Cardiac Progenitor Differentiation. Affiliated tissues include deep soft tissue, breast and small intestine.

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Related Diseases for Deep Leiomyoma

Diseases related to Deep Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma	29.2	PDGFRA KIT CD34
2	esophageal adenoid cystic carcinoma	10.1	KIT ANO1
3	gastric hemangioma	10.1	KIT ANO1
4	urethra leiomyoma	10.1	KIT CALD1
5	prostate embryonal rhabdomyosarcoma	10.1	KIT CALD1
6	mucinous stomach adenocarcinoma	10.1	KIT ANO1
7	active peptic ulcer disease	10.1	KIT ANO1
8	reticular perineurioma	10.1	PDGFRA KIT
9	laryngeal small cell carcinoma	10.1	PDGFRA KIT
10	uterus leiomyosarcoma	10.1	KIT CALD1
11	pulmonary vein stenosis	10.1	PDGFRA KIT
12	lung combined type small cell carcinoma	10.1	GFAP CALD1
13	myeloid and lymphoid neoplasms associated with pdgfra rearrangement	10.0	PDGFRA KIT
14	hypereosinophilic syndrome, idiopathic	10.0	PDGFRA KIT
15	sm-ahnmd	10.0	PDGFRA KIT
16	endometrial small cell carcinoma	10.0	PDGFRA KIT
17	perivascular epithelioid cell tumor	10.0	KIT CALD1
18	perineurioma	10.0	KIT GFAP
19	carney triad	10.0	PDGFRA KIT
20	fibrosarcoma of bone	10.0	PDGFRA KIT
21	myelodysplastic/myeloproliferative neoplasm	10.0	PDGFRA KIT
22	plexiform neurofibroma	10.0	PDGFRA KIT
23	parasagittal meningioma	10.0	CD34 ANO1
24	glomangioma	10.0	CD34 CALD1
25	mixed glioma	10.0	PDGFRA GFAP
26	chronic eosinophilic leukemia	10.0	PDGFRA KIT
27	intravascular angioleiomyoma	10.0	CD34 CALD1
28	pulmonary artery leiomyosarcoma	9.9	CD34 ANO1
29	breast myofibroblastoma	9.9	CD34 CALD1
30	large cell neuroendocrine carcinoma	9.9	PDGFRA KIT
31	pulmonary vein leiomyosarcoma	9.9	CD34 CALD1
32	glomangiomyoma	9.9	CD34 CALD1
33	vulvar leiomyosarcoma	9.9	CD34 CALD1
34	peritoneal benign neoplasm	9.9	CD34 CALD1
35	glomangiosarcoma	9.9	CD34 CALD1
36	adult fibrosarcoma	9.9	CD34 CALD1
37	cervical polyp	9.9	CD34 CALD1
38	testicular fibroma	9.9	CD34 CALD1
39	intravenous leiomyomatosis	9.9	CD34 CALD1
40	sarcomatoid squamous cell skin carcinoma	9.9	CD34 CALD1
41	congenital granular cell tumor	9.9	CD34 CALD1
42	subungual glomus tumor	9.9	CD34 CALD1
43	glomus tumor	9.9	CD34 CALD1
44	spinal cord sarcoma	9.9	KIT CD34
45	vulvar leiomyoma	9.9	CD34 CALD1
46	cystic teratoma	9.9	KIT GFAP
47	infiltrating angiolipoma	9.9	CD34 CALD1
48	gallbladder leiomyoma	9.9	KIT CD34
49	epithelioid cell synovial sarcoma	9.9	CD34 ANO1
50	angiolipoma	9.9	CD34 CALD1

Graphical network of the top 20 diseases related to Deep Leiomyoma:

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Symptoms & Phenotypes for Deep Leiomyoma

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Drugs & Therapeutics for Deep Leiomyoma

Search Clinical Trials , NIH Clinical Center for Deep Leiomyoma

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Genetic Tests for Deep Leiomyoma

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Anatomical Context for Deep Leiomyoma

The Foundational Model of Anatomy Ontology organs/tissues related to Deep Leiomyoma:

¹⁹

Deep Soft Tissue

MalaCards organs/tissues related to Deep Leiomyoma:

⁴⁰

Breast, Small Intestine, Liver, Myeloid, Heart, Colon, Lung

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Publications for Deep Leiomyoma

Articles related to Deep Leiomyoma:

#	Title	Authors	PMID	Year
1	Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal. ⁶¹	Janevska V...Spasevska L	26884872	2015
2	A bizarre giant leiomyoma. ⁶¹	Tueche SG...Cesari J	11357051	2001
3	DEEP LEIOMYOMA OF AN EXTREMITY. ⁶¹	GOODMAN AH...BRIGGS RC	14275173	1965

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Genes for Deep Leiomyoma

Genes related to Deep Leiomyoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD177	CD177 Molecule	Protein Coding	6.06	DISEASES inferred ¹⁵
2	ANO1	Anoctamin 1	Protein Coding	6.05	DISEASES inferred ¹⁵
3	CALD1	Caldesmon 1	Protein Coding	5.66	DISEASES inferred ¹⁵
4	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	5.1	DISEASES inferred ¹⁵
5	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	4.78	DISEASES inferred ¹⁵
6	CD34	CD34 Molecule	Protein Coding	4.48	DISEASES inferred ¹⁵
7	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	3.64	DISEASES inferred ¹⁵

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Variations for Deep Leiomyoma

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Expression for Deep Leiomyoma

Search GEO for disease gene expression data for Deep Leiomyoma.

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Pathways for Deep Leiomyoma

Pathways related to Deep Leiomyoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Development Angiotensin activation of ERK ²³ Show member pathways Cell adhesion Integrin inside-out signaling ²³ Development ACM2 and ACM4 activation of ERK ²³ Development Angiotensin signaling via PYK2 ²³ Development EDNRB signaling ²³ Development EPO-induced MAPK pathway ²³ Development G-Proteins mediated regulation MARK-ERK signaling ²³ Signal transduction IP3 signaling ²³	12.19	PDGFRA KIT CALD1
2	Cardiac Progenitor Differentiation ¹	10.88	PDGFRA KIT
3	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	10.67	PDGFRA KIT
4	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.15	PDGFRA KIT

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GO Terms for Deep Leiomyoma

Cellular components related to Deep Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.8	PDGFRA KIT CD34

Biological processes related to Deep Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hematopoietic progenitor cell differentiation	GO:0002244	9.16	PDGFRA KIT
2	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	8.96	PDGFRA KIT
3	positive regulation of phospholipase C activity	GO:0010863	8.62	PDGFRA KIT

Molecular functions related to Deep Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.62	PDGFRA KIT

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Sources for Deep Leiomyoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia