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MCID: DFC004
MIFTS: 66

Deficiency Anemia

Categories: Blood diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Deficiency Anemia

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MalaCards integrated aliases for Deficiency Anemia:

Name: Deficiency Anemia 41 12 15
Anemia 41 12 76 29 55 6 43 44 15 63 40 73
Deficiency Anemias 12 73
Anaemia 12 15

Classifications:

MalaCards categories:
Anatomical: Blood diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:13121 DOID:2355
ICD9CM 35 281.9 285.9
ICD10 33 D64.9
MeSH 44 D000740
NCIt 50 C2869
SNOMED-CT 68 64593003
Sources

Summaries for Deficiency Anemia

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MedlinePlus : 43 If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body. Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction. Conditions that may lead to anemia include Heavy periods Pregnancy Ulcers Colon polyps or colon cancer Inherited disorders A diet that does not have enough iron, folic acid or vitamin B12 Blood disorders such as sickle cell anemia and thalassemia, or cancer Aplastic anemia, a condition that can be inherited or acquired G6PD deficiency, a metabolic disorder Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache. Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Deficiency Anemia, also known as anemia, is related to iron-refractory iron deficiency anemia and anemia, sideroblastic, 1, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Deficiency Anemia is TF (Transferrin), and among its related pathways/superpathways are Glucose / Energy Metabolism and Insulin receptor recycling. The drugs Copper and Zinc have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.

PubMed Health : 63 About anemia: Anemia (uh-NEE-me-uh) is a condition in which your blood has a lower than normal number of red blood cells.Anemia also can occur if your red blood cells don't contain enough hemoglobin (HEE-muh-glow-bin). Hemoglobin is an iron-rich protein that gives blood its red color. This protein helps red blood cells carry oxygen from the lungs to the rest of the body.If you have anemia, your body doesn't get enough oxygen-rich blood. As a result, you may feel tired or weak. You also may have other symptoms, such as shortness of breath, dizziness, or headaches.Severe or long-lasting anemia can damage your heart, brain, and other organs in your body. Very severe anemia may even cause death.

Wikipedia : 76 Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a... more...

Sources

Related Diseases for Deficiency Anemia

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Diseases related to Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1744)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.3 EPO HJV TMPRSS6
2 anemia, sideroblastic, 1 34.2 HAMP HBB TFRC
3 aplastic anemia 33.9 ALB CSF3 EPO HFE IL6 THPO
4 hypochromic microcytic anemia 33.7 CP HBB SLC11A2 TF TMPRSS6
5 folic acid deficiency anemia 33.6 CRP EPO TF TFRC THPO
6 iron deficiency anemia 33.5 CRP EPO HAMP HFE HJV IL6
7 hereditary spherocytosis 33.3 G6PD HBB HFE TFRC
8 cold agglutinin disease 33.0 CRP IL6
9 proteasome-associated autoinflammatory syndrome 1 32.7 ALB CRP IL6
10 microcytic anemia 32.5 EPO SLC11A2 TF TFRC TMPRSS6
11 iron metabolism disease 32.4 CP EPO HFE HJV SLC11A2 SLC40A1
12 myelodysplastic syndrome 32.3 CSF3 EPO EPOR HFE TF TFRC
13 glucosephosphate dehydrogenase deficiency 32.3 G6PD HBB HBG2
14 pure red-cell aplasia 32.2 ALB EPO TF
15 hyperferritinemia with or without cataract 32.2 HFE TF
16 myeloma, multiple 32.1 ALB CRP CSF3 EPO IL6
17 atransferrinemia 32.0 CP EPOR HAMP HFE HJV SLC11A2
18 hypersplenism 31.9 ALB EPO THPO
19 hemoglobin h disease 31.9 EPO G6PD HBB HBG2 TF TFRC
20 end stage renal failure 31.8 ALB CRP EPO IL6 TF
21 aceruloplasminemia 31.7 CP HAMP HFE HJV TF TFR2
22 fetal erythroblastosis 31.4 ALB EPO TFRC
23 hemochromatosis, type 4 31.2 HAMP HFE HJV SLC40A1 TF TFR2
24 bone marrow cancer 31.2 CSF3 EPO EPOR IL6 THPO
25 thalassemia 31.0 EPO HBB HFE TF TFRC
26 thrombocytosis 30.7 CRP EPO IL6 THPO
27 methemoglobinemia 30.6 G6PD HBB HBG2
28 kidney disease 30.5 ALB CRP EPO IL6 TF
29 beta-thalassemia 30.4 EPO G6PD HBB HBG2 HFE TF
30 chronic kidney failure 30.4 ALB CRP EPO EPOR IL6 TF
31 analbuminemia 30.4 ALB CRP EPO TF
32 endocarditis 30.3 ALB CRP IL6
33 hemosiderosis 30.3 CP EPO HAMP HFE SLC11A2 SLC40A1
34 trypanosomiasis 30.3 ALB IL6 TF
35 splenic sequestration 30.3 HBB THPO
36 cholangitis 30.3 ALB CRP IL6
37 uremia 30.2 ALB CRP EPO TF
38 hemoglobinopathy 30.2 EPO HAMP HBB HFE TF
39 acquired immunodeficiency syndrome 30.1 ALB EPO IL6
40 arteries, anomalies of 30.1 ALB CRP IL6
41 wilson disease 30.1 ALB CP HFE TF
42 restless legs syndrome 30.1 EPO SLC11A2 TFRC
43 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 30.0 HBB HBG2
44 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 30.0 HBB HBG2
45 coronary stenosis 30.0 ALB CRP IL6
46 siderosis 30.0 HBB HFE SLC40A1 TF TFRC
47 meningitis 30.0 ALB CRP IL6
48 purpura 30.0 CRP IL6 THPO
49 pancytopenia 30.0 CSF3 EPO THPO
50 polycythemia 30.0 EPO EPOR TFRC THPO

Comorbidity relations with Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 336)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Acute Kidney Failure
Acute Leukemia Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Adjustment Disorder Adrenal Gland Disease
Agammaglobulinemia, X-Linked Alcohol Abuse
Alcoholic Gastritis Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Alzheimer Disease Amyloidosis
Anemia, Autoimmune Hemolytic Anus Cancer
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Asbestosis Ascending Colon Cancer
Aspergillosis Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autonomic Nervous System Disease Bacteremia 2
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Biliary Tract Neoplasm
Bladder Cancer Bleeding Disorder, Platelet-Type, 11
Blepharitis Bronchiectasis
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cardiogenic Shock

Graphical network of the top 20 diseases related to Deficiency Anemia:



Diseases related to Deficiency Anemia
Sources

Symptoms & Phenotypes for Deficiency Anemia

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UMLS symptoms related to Deficiency Anemia:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Deficiency Anemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CSF3 EPOR HFE TFR2 TFRC

MGI Mouse Phenotypes related to Deficiency Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 CP CSF3 EPO EPOR G6PD HFE
2 homeostasis/metabolism MP:0005376 10.22 ALB CP CRP EPO EPOR G6PD
3 cardiovascular system MP:0005385 10.14 CP CRP EPO EPOR G6PD HJV
4 immune system MP:0005387 10.1 CP CRP CSF3 EPO EPOR HFE
5 integument MP:0010771 9.76 CSF3 EPO HJV IL6 SLC11A2 SLC40A1
6 liver/biliary system MP:0005370 9.73 ALB CP EPO EPOR HFE HJV
7 mortality/aging MP:0010768 9.4 ALB EPO EPOR G6PD HFE HJV
Sources

Drugs & Therapeutics for Deficiency Anemia

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PubMedHealth treatment related to Deficiency Anemia: 63

Treatment for anemia depends on the type, cause, and severity of the condition. Treatments may include dietary changes or supplements, medicines, procedures, or surgery to treat blood loss.

Drugs for Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 193)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Copper Approved, Investigational Phase 4,Not Applicable 7440-50-8 27099
2
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-66-6
3
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
4
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
5
Tocopherol Approved, Investigational Phase 4,Phase 1,Not Applicable 1406-66-2 14986
6
Halofantrine Approved Phase 4 69756-53-2 37393
7
Ferrous fumarate Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 141-01-5
8
Methylcobalamin Approved, Experimental, Investigational Phase 4,Not Applicable 13422-55-4
9
Hydroxocobalamin Approved Phase 4,Not Applicable 13422-51-0 11953898 44475014
10
Selenium Approved, Investigational, Vet_approved Phase 4,Not Applicable 7782-49-2
11
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
12
Nicotinamide Approved, Investigational Phase 4,Not Applicable 98-92-0 936
13
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
14
Metronidazole Approved Phase 4 443-48-1 4173
15
Clarithromycin Approved Phase 4 81103-11-9 84029
16
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 59-02-9 14985
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
18
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable,Early Phase 1 50-81-7 5785 54670067
19
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 11103-57-4, 68-26-8 445354
20
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 1406-16-2
21
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
22
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 65-23-6 1054
23
Cyanocobalamin Approved, Nutraceutical Phase 4,Not Applicable 68-19-9 44176380
24
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-43-8, 70-16-6 1130
25
Niacin Approved, Investigational, Nutraceutical Phase 4,Not Applicable 59-67-6 938
26
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 83-88-5 493570
27
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
28 Tocotrienol Investigational Phase 4,Phase 1,Not Applicable 6829-55-6
29
Cobalamin Experimental Phase 4,Not Applicable 13408-78-1 6438156
30 Antioxidants Phase 4,Phase 3,Phase 1,Not Applicable
31 Tocopherols Phase 4,Phase 1,Not Applicable
32 Vitamin B Complex Phase 4,Phase 3,Phase 2,Not Applicable
33 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Iron Supplement Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Tocotrienols Phase 4,Phase 1,Not Applicable
37 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Vitamin B9 Phase 4,Phase 3,Phase 2,Not Applicable
39 Folate Phase 4,Phase 3,Phase 2,Not Applicable
40 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Ferric oxide, saccharated Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Hematinics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Teferrol Phase 4,Not Applicable
44 retinol Phase 4,Phase 3,Phase 2,Not Applicable
45 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable
46 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Ferrosoferric Oxide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Parenteral Nutrition Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Calciferol Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 332)
# Name Status NCT ID Phase Drugs
1 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
2 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
3 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
4 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
5 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
6 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Unknown status NCT02997046 Phase 4
7 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
8 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
9 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
10 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
11 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
12 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
13 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
14 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
15 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
16 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
17 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
18 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
19 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
20 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
21 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
22 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
23 Oral Lactoferrin Versus Iron Supplementation During Pregnancy Completed NCT03542825 Phase 4 Lactoferrin;Iron Supplement;Chelates, Iron
24 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
25 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
26 Prenatal Iron and Malaria Study Completed NCT01308112 Phase 4
27 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
28 Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia Recruiting NCT03524651 Phase 4 Ferrous Sulfate;Fe-ASP;Ferrous Sulfate;Fe-ASP
29 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Recruiting NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
30 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
31 A Trial Comparing the Incidence of Hypophosphatemia in Relation to Treatment With Iron Isomaltoside and Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia Due to Inflammatory Bowel Disease Recruiting NCT03466983 Phase 4 Iron Isomaltoside;Ferric Carboxymaltose
32 Iron Deficiency Anemia, Iron Supplementation and Genomic Stability in Infants Recruiting NCT03359447 Phase 4 Weekly Ferrous Sulfate;Daily Ferrous Sulfate
33 Eradication of H-pylori in Pregnancy and Its Effect on Iron Replacement Therapy? Recruiting NCT03347513 Phase 4 triple attack therapy;Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
34 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Recruiting NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
35 FLIPS: Ferfer Liposomal Iron Performance Study Recruiting NCT03112187 Phase 4 Iron Supplement
36 Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy. Recruiting NCT03188445 Phase 4 Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
37 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
38 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
39 Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease Recruiting NCT02752191 Phase 4 ferumoxytol;gadofosveset
40 Preoperative Intravenous Iron Infusion to Reduce Post-surgical Complications: a Pilot Randomised Control Trial Recruiting NCT03295851 Phase 4 Ferric carboxymaltose;Ferrous Fumarate
41 Treatment Response of Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass Active, not recruiting NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
42 Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and to Compare Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs Intravenous Standard of Care for the Treatment of IDA in an Infusion Center Setting Active, not recruiting NCT01950247 Phase 4 Injectafer;SOC
43 KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) Active, not recruiting NCT03236246 Phase 4 KRX-0502
44 to Assess the Effect of Early vs Routine Iron Supplementation on Iron Store and Growth in Term Infants Active, not recruiting NCT03171324 Phase 4 Iron Supplement
45 Iron Treatment for Young Children With Non-anemic Iron Deficiency Active, not recruiting NCT01481766 Phase 4
46 Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. Active, not recruiting NCT01953107 Phase 4
47 Intravenous Iron Isomaltoside 1000 (Monofer®) Compared With Oral Iron in the Treatment of Postgastrectomy Anemia: An Open-label Randomized Controlled Trial Enrolling by invitation NCT03229954 Phase 4 iron isomaltoside (Monofer) intravenous infusion;Ferrous sulfate(Feroba-YOU) per oral
48 the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis Not yet recruiting NCT03748043 Phase 4 Lactoferrin;Ferric Hydroxide Polymaltose
49 ORal IrON Supplementation With Ferric Maltol in Patients With Heart Failure Carrying Left Ventricular Assist Devices Not yet recruiting NCT03774615 Phase 4 Ferric maltol 30 mg (Feraccru®)
50 Trial Comparing the Safety of Two Different Intravenous Iron Formulations Suspended NCT00593619 Phase 4 Iron dextran;Iron sucrose

Search NIH Clinical Center for Deficiency Anemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: anemia

Sources

Genetic Tests for Deficiency Anemia

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Genetic tests related to Deficiency Anemia:

# Genetic test Affiliating Genes
1 Anemia 29
Sources

Anatomical Context for Deficiency Anemia

About this section

MalaCards organs/tissues related to Deficiency Anemia:

41
Kidney, Bone, Bone Marrow, Myeloid, Heart, T Cells, Breast
Sources

Publications for Deficiency Anemia

About this section

Articles related to Deficiency Anemia:

(show top 50) (show all 2059)
# Title Authors Year
1
A response to the letter to the editor on Shaikh et al. Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect. ( 29587606 )
2019
2
Hidden hearing loss in children and adolescents with sickle cell anemia. ( 30554696 )
2019
3
Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. ( 30255556 )
2019
4
Clinical experience with ferric carboxymaltose in the management of anemia in acute gastrointestinal bleeding. ( 30335628 )
2019
5
Impact of Nursing Education on Phlebotomy Blood Loss and Hospital-Acquired Anemia: A Quality Improvement Project. ( 30499788 )
2019
6
Vitamin D deficiency and mild to moderate anemia in young North Indian children: A secondary data analysis. ( 30153581 )
2019
7
Fermented goat milk consumption improves cardiovascular health during anemia recovery. ( 30014470 )
2019
8
Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. ( 29795991 )
2018
9
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
10
Protein-Losing Enteropathy in the Setting of Severe Iron Deficiency Anemia. ( 29511696 )
2018
11
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2018
12
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the BogotA! School Children Cohort. ( 29897579 )
2018
13
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
14
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs. ( 29772815 )
2018
15
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
16
A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review. ( 29851802 )
2018
17
Cooking in Iron Pots for Iron Deficiency Anemia: The Traditional Way Forward? ( 29948738 )
2018
18
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
19
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. ( 29535446 )
2018
20
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
21
Copper deficiency anemia: review article. ( 29959467 )
2018
22
Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. ( 29850236 )
2018
23
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
24
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
25
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
26
A comment on the comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia. ( 29981266 )
2018
27
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia. ( 29868633 )
2018
28
Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of iron deficiency anemia with pregnancy: a randomized double-blind clinical trial. ( 29843553 )
2018
29
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
30
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
31
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
32
The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia. ( 29928945 )
2018
33
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
34
Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis. ( 29767699 )
2018
35
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
36
Iron Deficiency Anemia with Menorrhagia: Ferric Carboxymaltose a Safer Alternative to Blood Transfusion. ( 29962808 )
2018
37
New Onset Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange Patients. ( 29970428 )
2018
38
Relation between Depressive Disorder and Iron Deficiency Anemia among Adults Reporting to a Secondary Healthcare Facility: A Hospital-Based Case Control Study. ( 29848423 )
2018
39
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. ( 29917215 )
2018
40
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
41
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
42
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
43
Effects of an enhanced iron dense foods offering in the daily meals served in geriatric institutions on measures of iron deficiency anemia. ( 29801478 )
2018
44
Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure. ( 29961562 )
2018
45
A Toddler With Treatment-Resistant Iron Deficiency Anemia. ( 29950397 )
2018
46
Limited Exchange Transfusion Can Be Very Beneficial in Sickle Cell Anemia with Acute Chest Syndrome: A Case Report from Tanzania. ( 30034890 )
2018
47
Five-year outcomes in patients with anemia on admission undergoing a coronary intervention for acute myocardial infarction in Koreans: propensity score matching analysis. ( 30074518 )
2018
48
Association between admission anemia and long-term mortality in patients with acute myocardial infarction: results from the MONICA/KORA myocardial infarction registry. ( 29523073 )
2018
49
Feasibility of Intravenous Iron Isomaltoside to Improve Anemia and Quality of Life During Palliative Chemotherapy for Esophagogastric Adenocarcinoma. ( 30198775 )
2018
50
The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females. ( 30507999 )
2018
Sources

Variations for Deficiency Anemia

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ClinVar genetic disease variations for Deficiency Anemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HBB; HBD; LOC106099062; LOC106099063; LOC107133510; LOC110006319 NG_000007.3: g.63632_71046del7415 deletion Pathogenic GRCh38 Chromosome 11, 5226570: 5233984
2 HBB; HBD; LOC106099062; LOC106099063; LOC107133510; LOC110006319 NG_000007.3: g.63632_71046del7415 deletion Pathogenic GRCh37 Chromosome 11, 5247800: 5255214
3 HBA1; HBA2; LOC106804612 NM_000517.4(HBA2): c.410T> C (p.Leu137Pro) single nucleotide variant Pathogenic rs41469945 GRCh37 Chromosome 16, 223580: 223580
4 HBA1; HBA2; LOC106804612 NM_000517.4(HBA2): c.410T> C (p.Leu137Pro) single nucleotide variant Pathogenic rs41469945 GRCh38 Chromosome 16, 173581: 173581
5 ANK1 NM_001142446.1(ANK1): c.2047A> G (p.Met683Val) single nucleotide variant Uncertain significance rs1057518790 GRCh37 Chromosome 8, 41566346: 41566346
6 ANK1 NM_001142446.1(ANK1): c.2047A> G (p.Met683Val) single nucleotide variant Uncertain significance rs1057518790 GRCh38 Chromosome 8, 41708828: 41708828
7 GATA2 NM_001145661.1(GATA2): c.971A> G (p.Lys324Arg) single nucleotide variant Uncertain significance GRCh38 Chromosome 3, 128483906: 128483906
8 GATA2 NM_001145661.1(GATA2): c.971A> G (p.Lys324Arg) single nucleotide variant Uncertain significance GRCh37 Chromosome 3, 128202749: 128202749
Sources

Expression for Deficiency Anemia

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Search GEO for disease gene expression data for Deficiency Anemia.
Sources

Pathways for Deficiency Anemia

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Pathways related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
12.35 CP G6PD HBB SLC11A2
2
Insulin receptor recycling 66
Show member pathways
 12.28 CP SLC11A2 SLC40A1 TF TFRC
3
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.22 CSF3 EPO EPOR IL6 THPO
4
Selenium Micronutrient Network 1
Show member pathways
 12.17 ALB CRP HBB IL6
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.77 CSF3 EPO IL6 THPO
6
Metal ion SLC transporters 66
Show member pathways
 11.71 CP SLC11A2 SLC40A1
7
HIF-1 signaling pathway 37
11.67 EPO IL6 TF TFRC
8
Hematopoietic cell lineage 37
11.62 CSF3 EPO EPOR IL6 TFRC THPO
9
HIF-1-alpha transcription factor network 1
11.44 CP EPO TF TFRC
10
Mineral absorption 37
11.41 SLC11A2 SLC40A1 TF
11
Malaria 37
11.38 CSF3 HBB IL6
12
Differentiation Pathway 1
11.35 EPO IL6 TF
13
Hematopoietic Stem Cell Differentiation 1
11.33 CSF3 EPO IL6
14
Ferroptosis 37
11.26 CP SLC11A2 SLC40A1 TF TFRC
15
Iron metabolism in placenta 1
10.18 HAMP SLC11A2 SLC40A1 TF TFR2 TFRC
16
Hfe effect on hepcidin production 1
10.1 HAMP HFE HJV TMPRSS6
Sources

GO Terms for Deficiency Anemia

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Cellular components related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB CP CRP CSF3 EPO HAMP
2 endoplasmic reticulum lumen GO:0005788 9.78 ALB CP IL6 TF
3 early endosome GO:0005769 9.73 HFE SLC11A2 TF TFRC
4 recycling endosome GO:0055037 9.67 HFE SLC11A2 TF TFRC
5 blood microparticle GO:0072562 9.63 ALB CP HBB HBG2 TF TFRC
6 basal part of cell GO:0045178 9.5 HFE SLC11A2 TF
7 hemoglobin complex GO:0005833 9.46 HBB HBG2
8 haptoglobin-hemoglobin complex GO:0031838 9.4 HBB HBG2
9 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC
10 extracellular region GO:0005576 10.03 ALB CP CRP CSF3 EPO EPOR

Biological processes related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.93 CSF3 EPO HAMP IL6 THPO
2 cellular protein metabolic process GO:0044267 9.85 ALB CP IL6 TF
3 receptor-mediated endocytosis GO:0006898 9.83 ALB HBB TFR2 TFRC
4 cellular oxidant detoxification GO:0098869 9.75 ALB HBB HBG2
5 transferrin transport GO:0033572 9.71 HFE TF TFR2 TFRC
6 response to iron ion GO:0010039 9.67 HAMP HFE SLC11A2 TFR2
7 acute-phase response GO:0006953 9.63 CRP EPO HAMP HFE IL6 TFR2
8 iron ion transport GO:0006826 9.62 SLC11A2 SLC40A1 TF TFR2
9 cellular response to iron ion GO:0071281 9.61 HFE TF TFR2
10 oxygen transport GO:0015671 9.6 HBB HBG2
11 copper ion transport GO:0006825 9.59 CP SLC11A2
12 erythrocyte maturation GO:0043249 9.58 EPO G6PD
13 negative regulation of lipid storage GO:0010888 9.57 CRP IL6
14 positive regulation of peptide hormone secretion GO:0090277 9.56 HFE TFR2
15 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A2 SLC40A1
16 erythropoietin-mediated signaling pathway GO:0038162 9.51 EPO EPOR
17 iron ion homeostasis GO:0055072 9.5 HFE HJV SLC11A2 SLC40A1 TF TFR2
18 iron ion import GO:0097286 9.49 TFR2 TFRC
19 regulation of iron ion import GO:1900390 9.48 HFE TF
20 response to iron ion starvation GO:1990641 9.46 HAMP HFE
21 cellular iron ion homeostasis GO:0006879 9.32 CP HAMP HFE HJV SLC11A2 SLC40A1

Molecular functions related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.73 CSF3 EPO IL6 THPO
2 hormone activity GO:0005179 9.7 EPO HAMP THPO
3 copper ion binding GO:0005507 9.58 ALB CP SLC11A2
4 oxygen carrier activity GO:0005344 9.51 HBB HBG2
5 co-receptor binding GO:0039706 9.49 HFE TFR2
6 organic acid binding GO:0043177 9.48 HBB HBG2
7 haptoglobin binding GO:0031720 9.46 HBB HBG2
8 oxygen binding GO:0019825 9.43 ALB HBB HBG2
9 iron ion transmembrane transporter activity GO:0005381 9.37 SLC11A2 SLC40A1
10 ferrous iron transmembrane transporter activity GO:0015093 9.32 SLC11A2 SLC40A1
11 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
12 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
13 transferrin receptor binding GO:1990459 8.8 HFE HJV TF
Sources

Sources for Deficiency Anemia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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