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MCID: DFC004
MIFTS: 61

Deficiency Anemia

Categories: Blood diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Deficiency Anemia

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MalaCards integrated aliases for Deficiency Anemia:

Name: Deficiency Anemia 41 12 15
Anemia 41 12 76 29 55 6 43 44 15 63 40 73
Deficiency Anemias 12 73
Anaemia 12

Classifications:

MalaCards categories:
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Deficiency Anemia

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MedlinePlus : 43 If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body. Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction. Conditions that may lead to anemia include Heavy periods Pregnancy Ulcers Colon polyps or colon cancer Inherited disorders A diet that does not have enough iron, folic acid or vitamin B12 Blood disorders such as sickle cell anemia and thalassemia, or cancer Aplastic anemia, a condition that can be inherited or acquired G6PD deficiency, a metabolic disorder Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache. Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Deficiency Anemia, also known as anemia, is related to iron-refractory iron deficiency anemia and anemia, sideroblastic, 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Deficiency Anemia is TF (Transferrin), and among its related pathways/superpathways are Regulation of IFNA signaling and Insulin receptor recycling. The drugs Zinc and Iron have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and colon, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.

PubMed Health : 63 About anemia: Anemia (uh-NEE-me-uh) is a condition in which your blood has a lower than normal number of red blood cells.Anemia also can occur if your red blood cells don't contain enough hemoglobin (HEE-muh-glow-bin). Hemoglobin is an iron-rich protein that gives blood its red color. This protein helps red blood cells carry oxygen from the lungs to the rest of the body.If you have anemia, your body doesn't get enough oxygen-rich blood. As a result, you may feel tired or weak. You also may have other symptoms, such as shortness of breath, dizziness, or headaches.Severe or long-lasting anemia can damage your heart, brain, and other organs in your body. Very severe anemia may even cause death.

Wikipedia : 76 Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a... more...

Sources

Related Diseases for Deficiency Anemia

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Diseases related to Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 35.2 EPO HJV TMPRSS6
2 anemia, sideroblastic, 1 35.0 HAMP HBB TFRC
3 aplastic anemia 34.4 CSF3 EPO HFE IL6 THPO
4 folic acid deficiency anemia 34.2 CRP EPO TF TFRC THPO
5 microcytic anemia 33.1 EPO SLC11A2 TF TFRC TMPRSS6
6 glucosephosphate dehydrogenase deficiency 32.9 G6PD HBB HBG2
7 iron deficiency anemia 32.5 CRP EPO HAMP HFE HJV IL6
8 iron metabolism disease 32.1 CP EPO HFE HJV SLC11A2 SLC40A1
9 thalassemia 31.4 EPO HBB HFE TF TFRC
10 thrombocytosis 31.4 CRP EPO IL6 THPO
11 chronic kidney failure 30.8 ALB CRP EPO IL6 TF
12 hemoglobinopathy 30.7 EPO HAMP HBB TF
13 pancytopenia 30.7 CSF3 EPO THPO
14 hyperferritinemia with or without cataract 30.7 HFE TF
15 sickle cell disease 30.6 EPO G6PD HBB HBG2
16 dysentery 30.5 ALB CRP TF
17 anemia of prematurity 30.5 CSF3 EPO EPOR HAMP
18 congenital hemolytic anemia 30.5 EPO G6PD HBB TF
19 hemolytic anemia 30.5 EPO G6PD HBB HBG2
20 polycythemia 30.4 EPO EPOR TFRC THPO
21 sickle cell anemia 30.4 EPO HBB HBG2
22 intestinal disease 30.3 ALB CRP IL6
23 protein-energy malnutrition 30.3 ALB CP IL6 TF
24 hemosiderosis 30.2 CP EPO HAMP HFE SLC11A2 SLC40A1
25 hypochromic microcytic anemia 30.2 CP HBB SLC11A2 TF TMPRSS6
26 beta-thalassemia 30.1 EPO G6PD HAMP HBB HBG2 HFE
27 restless legs syndrome 30.0 EPO SLC11A2 TFRC
28 diabetes mellitus 29.6 ALB CP CRP EPO HBB HFE
29 malaria 29.2 ALB CRP CSF3 EPO G6PD HAMP
30 hemochromatosis, type 1 28.8 CP HAMP HBB HFE HJV SLC11A2
31 fanconi anemia, complementation group a 12.4
32 diamond-blackfan anemia 12.4
33 thiamine-responsive megaloblastic anemia syndrome 12.3
34 protein-deficiency anemia 12.0
35 pyridoxine deficiency anemia 11.9
36 hereditary orotic aciduria without megaloblastic anaemia 11.9
37 adenosine triphosphatase deficiency, anemia due to 11.8
38 anemia, autoimmune hemolytic 11.4
39 myopathy, lactic acidosis, and sideroblastic anemia 1 11.4
40 iron overload in africa 11.2 HFE TF
41 vibrio vulnificus infection 11.1 EPO IL6
42 pyruvate kinase deficiency of red cells 11.1
43 hemochromatosis, type 2a 11.1 HAMP HJV
44 acquired methemoglobinemia 11.1 G6PD HBG2
45 plummer vinson syndrome 11.0
46 cold agglutinin disease 11.0 CRP IL6
47 gastric antral vascular ectasia 11.0
48 autoimmune atrophic gastritis 11.0
49 congenital methemoglobinemia 11.0 G6PD HBG2
50 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 11.0 HBB HBG2

Comorbidity relations with Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 340)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Acute Kidney Failure
Acute Leukemia Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Adjustment Disorder Adrenal Gland Disease
Agammaglobulinemia, X-Linked Alcohol Abuse
Alcoholic Gastritis Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Alzheimer Disease Amyloidosis
Anemia, Autoimmune Hemolytic Anus Cancer
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Asbestosis Ascending Colon Cancer
Aspergillosis Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autonomic Nervous System Disease Bacteremia 2
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Biliary Tract Neoplasm
Bladder Cancer Bleeding Disorder, Platelet-Type, 11
Blepharitis Bronchiectasis
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cardiogenic Shock

Graphical network of the top 20 diseases related to Deficiency Anemia:



Diseases related to Deficiency Anemia
Sources

Symptoms & Phenotypes for Deficiency Anemia

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UMLS symptoms related to Deficiency Anemia:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Deficiency Anemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CSF3 EPOR HFE TFR2 TFRC

MGI Mouse Phenotypes related to Deficiency Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 SLC11A2 SLC40A1 TF TFR2 TFRC THPO
2 homeostasis/metabolism MP:0005376 10.22 ALB CP CRP EPO EPOR G6PD
3 cardiovascular system MP:0005385 10.14 CP CRP EPO EPOR G6PD HJV
4 immune system MP:0005387 10.1 HFE HJV IL6 SLC11A2 SLC40A1 TFR2
5 integument MP:0010771 9.76 CSF3 EPO HJV IL6 SLC11A2 SLC40A1
6 liver/biliary system MP:0005370 9.73 ALB CP EPO EPOR HFE HJV
7 mortality/aging MP:0010768 9.4 ALB EPO EPOR G6PD HFE HJV
Sources

Drugs & Therapeutics for Deficiency Anemia

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PubMedHealth treatment related to Deficiency Anemia: 63

Treatment for anemia depends on the type, cause, and severity of the condition. Treatments may include dietary changes or supplements, medicines, procedures, or surgery to treat blood loss.

Drugs for Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 181)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-66-6 23994
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
3
Copper Approved, Investigational Phase 4,Not Applicable 7440-50-8 27099
4
Selenium Approved, Investigational, Vet_approved Phase 4,Not Applicable 7782-49-2
5
Hydroxocobalamin Approved Phase 4,Not Applicable 13422-51-0 11953898 44475014
6
Halofantrine Approved Phase 4 69756-53-2 37393
7
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
8
Clarithromycin Approved Phase 4 81103-11-9 84029
9
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable,Early Phase 1 50-81-7 5785 54670067
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 11103-57-4, 68-26-8 445354
13
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Not Applicable 98-92-0 936
14
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 58-05-9 143 6006
15
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 1406-16-2
16
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4,Not Applicable 13422-55-4
17
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 65-23-6 1054
18
Niacin Approved, Investigational, Nutraceutical Phase 4,Not Applicable 59-67-6 938
19
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
20
Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 1,Not Applicable 1406-66-2 14986
21
Pyridoxal Approved, Nutraceutical Phase 4,Not Applicable 66-72-8 1050
22
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 83-88-5 493570
23
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-43-8, 70-16-6 1130
24
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-30-3 6037
26
Cyanocobalamin Approved, Nutraceutical Phase 4,Not Applicable 68-19-9 44176380
27
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 59-02-9 14985
28 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Ferric oxide, saccharated Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable
31 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Hematinics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Teferrol Phase 4,Not Applicable
34 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Vitamins Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 ferric gluconate Phase 4,Phase 2,Phase 3
37 cadexomer iodine Phase 4,Not Applicable
38 Epoetin alfa Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113427-24-0
39 Ferrosoferric Oxide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Ferrous fumarate Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable
41 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
42 Gastrointestinal Agents Phase 4,Phase 1
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
44 Hepcidins Phase 4,Not Applicable
45 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
46 Tocopherols Phase 4,Phase 1,Not Applicable
47 Tocotrienols Phase 4,Phase 1,Not Applicable
48 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
49 Nicotinic Acids Phase 4,Not Applicable
50 Dextrans Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 308)
# Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
3 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
4 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
5 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
6 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
7 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
8 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
9 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
10 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
11 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
12 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
13 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
14 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
15 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
16 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
17 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
18 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
19 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
20 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
21 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
22 Prenatal Iron and Malaria Study Completed NCT01308112 Phase 4
23 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
24 Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia Recruiting NCT03524651 Phase 4 Ferrous Sulfate;Fe-ASP;Ferrous Sulfate;Fe-ASP
25 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Recruiting NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
26 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Recruiting NCT02774057 Phase 4 Captafer®;Iron Sulfate
27 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
28 KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) Recruiting NCT03236246 Phase 4 KRX-0502
29 Iron Deficiency Anemia, Iron Supplementation and Genomic Stability in Infants Recruiting NCT03359447 Phase 4 Weekly Ferrous Sulfate;Daily Ferrous Sulfate
30 Eradication of H-pylori in Pregnancy and Its Effect on Iron Replacement Therapy? Recruiting NCT03347513 Phase 4 triple attack therapy;Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
31 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Recruiting NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
32 FLIPS: Ferfer Liposomal Iron Performance Study Recruiting NCT03112187 Phase 4 Iron Supplement
33 Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy. Recruiting NCT03188445 Phase 4 Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
34 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
35 to Assess the Effect of Early vs Routine Iron Supplementation on Iron Store and Growth in Term Infants Recruiting NCT03171324 Phase 4 Iron Supplement
36 Iron Treatment for Young Children With Non-anemic Iron Deficiency Recruiting NCT01481766 Phase 4
37 Oral Lactoferrin Versus Iron Supplementation During Pregnancy Recruiting NCT03542825 Phase 4 Lactoferrin;Iron Supplement;Chelates, Iron
38 Intravenous Iron Isomaltoside 1000 (Monofer®) Compared With Oral Iron in the Treatment of Postgastrectomy Anemia: An Open-label Randomized Controlled Trial Recruiting NCT03229954 Phase 4 iron isomaltoside (Monofer) intravenous infusion;Ferrous sulfate(Feroba-YOU) per oral
39 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
40 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
41 Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease Recruiting NCT02752191 Phase 4 ferumoxytol;gadofosveset
42 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Recruiting NCT02997046 Phase 4
43 Preoperative Intravenous Iron Infusion to Reduce Post-surgical Complications: a Pilot Randomised Control Trial Recruiting NCT03295851 Phase 4 Ferric carboxymaltose;Ferrous Fumarate
44 Treatment Response of Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass Active, not recruiting NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
45 Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and to Compare Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs Intravenous Standard of Care for the Treatment of IDA in an Infusion Active, not recruiting NCT01950247 Phase 4 Injectafer;SOC
46 Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. Active, not recruiting NCT01953107 Phase 4
47 A Trial Comparing the Incidence of Hypophosphatemia in Relation to Treatment With Iron Isomaltoside and Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia Due to Inflammatory Bowel Disease Not yet recruiting NCT03466983 Phase 4 Iron Isomaltoside;Ferric Carboxymaltose
48 Trial Comparing the Safety of Two Different Intravenous Iron Formulations Suspended NCT00593619 Phase 4 Iron dextran;Iron sucrose
49 Ferric Carboxymaltose for Treatment of Anaemia of Cancer in Subjects With Multiple Myeloma Receiving Chemotherapy Terminated NCT01100879 Phase 4 Ferric carboxymaltose
50 Intravenous Ferric Carboxymaltose (Ferinject®) With or Without Erythropoietin in Patients Undergoing Orthopaedic Surgery Terminated NCT00706667 Phase 4 Ferinject ®

Search NIH Clinical Center for Deficiency Anemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: anemia

Sources

Genetic Tests for Deficiency Anemia

About this section

Genetic tests related to Deficiency Anemia:

# Genetic test Affiliating Genes
1 Anemia 29
Sources

Anatomical Context for Deficiency Anemia

About this section

MalaCards organs/tissues related to Deficiency Anemia:

41
Kidney, Heart, Colon, Lung, Testes, Brain, Liver
Sources

Publications for Deficiency Anemia

About this section

Articles related to Deficiency Anemia:

(show top 50) (show all 851)
# Title Authors Year
1
Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. ( 29795991 )
2018
2
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
3
Protein-Losing Enteropathy in the Setting of Severe Iron Deficiency Anemia. ( 29511696 )
2018
4
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2018
5
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the BogotA! School Children Cohort. ( 29897579 )
2018
6
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
7
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs. ( 29772815 )
2018
8
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
9
A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review. ( 29851802 )
2018
10
Cooking in Iron Pots for Iron Deficiency Anemia: The Traditional Way Forward? ( 29948738 )
2018
11
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
12
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. ( 29535446 )
2018
13
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
14
Copper deficiency anemia: review article. ( 29959467 )
2018
15
Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. ( 29850236 )
2018
16
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
17
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
18
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
19
A comment on the comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia. ( 29981266 )
2018
20
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia. ( 29868633 )
2018
21
Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of iron deficiency anemia with pregnancy: a randomized double-blind clinical trial. ( 29843553 )
2018
22
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
23
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
24
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
25
The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia. ( 29928945 )
2018
26
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
27
Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis. ( 29767699 )
2018
28
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
29
Iron Deficiency Anemia with Menorrhagia: Ferric Carboxymaltose a Safer Alternative to Blood Transfusion. ( 29962808 )
2018
30
New Onset Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange Patients. ( 29970428 )
2018
31
Relation between Depressive Disorder and Iron Deficiency Anemia among Adults Reporting to a Secondary Healthcare Facility: A Hospital-Based Case Control Study. ( 29848423 )
2018
32
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. ( 29917215 )
2018
33
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
34
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
35
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
36
Effects of an enhanced iron dense foods offering in the daily meals served in geriatric institutions on measures of iron deficiency anemia. ( 29801478 )
2018
37
Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure. ( 29961562 )
2018
38
A Toddler With Treatment-Resistant Iron Deficiency Anemia. ( 29950397 )
2018
39
Effect of dietary intervention treatment on children with iron deficiency anemia in China: a meta-analysis. ( 29747646 )
2018
40
Correction to: Carvalho et al., Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease. ( 28853335 )
2017
41
Reply: Intravenous Ferumoxytol in Pediatric Patients With Iron-Deficiency Anemia. ( 28831808 )
2017
42
Cerebral Venous Thrombosis in a Patient with Iron Deficiency Anemia and Thrombocytopenia: A Case Report. ( 29362628 )
2017
43
VON WILLEBRAND FACTOR IMMUNOHISTOCHEMICAL STAINING QUANTITATIVE OPTICAL DENSITY PARAMETERS IN THE ENDOTHELIUM AND FIBRINOID OF THE PLACENTA DURING SECUNDINES INFLAMMATION AND CONCOMITANT IRON DEFICIENCY ANEMIA IN GRAVIDAS. ( 29328041 )
2017
44
Efficacy of oral methylcobalamin in treatment of vitamin B12 deficiency anemia in children. ( 28667789 )
2017
45
Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia. ( 29282766 )
2017
46
The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease. ( 29023457 )
2017
47
Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. ( 28849623 )
2017
48
Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. ( 28460265 )
2017
49
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia. ( 28934514 )
2017
50
A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia. ( 28052413 )
2017
Sources

Variations for Deficiency Anemia

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ClinVar genetic disease variations for Deficiency Anemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HBB; HBD; LOC106099062; LOC106099063; LOC107133510; LOC110006319 NG_000007.3: g.63632_71046del7415 deletion Pathogenic GRCh38 Chromosome 11, 5226570: 5233984
2 HBB; HBD; LOC106099062; LOC106099063; LOC107133510; LOC110006319 NG_000007.3: g.63632_71046del7415 deletion Pathogenic GRCh37 Chromosome 11, 5247800: 5255214
3 HBA1; HBA2; LOC106804612 NM_000517.4(HBA2): c.410T> C (p.Leu137Pro) single nucleotide variant Pathogenic rs41469945 GRCh37 Chromosome 16, 223580: 223580
4 HBA1; HBA2; LOC106804612 NM_000517.4(HBA2): c.410T> C (p.Leu137Pro) single nucleotide variant Pathogenic rs41469945 GRCh38 Chromosome 16, 173581: 173581
5 46;XX;t(4;14)(p15.2;q13)dn Translocation Likely pathogenic
6 ANK1 NM_001142446.1(ANK1): c.2047A> G (p.Met683Val) single nucleotide variant Uncertain significance rs1057518790 GRCh37 Chromosome 8, 41566346: 41566346
7 ANK1 NM_001142446.1(ANK1): c.2047A> G (p.Met683Val) single nucleotide variant Uncertain significance rs1057518790 GRCh38 Chromosome 8, 41708828: 41708828
8 GATA2 NM_001145661.1(GATA2): c.971A> G (p.Lys324Arg) single nucleotide variant Uncertain significance GRCh38 Chromosome 3, 128483906: 128483906
9 GATA2 NM_001145661.1(GATA2): c.971A> G (p.Lys324Arg) single nucleotide variant Uncertain significance GRCh37 Chromosome 3, 128202749: 128202749
Sources

Expression for Deficiency Anemia

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Search GEO for disease gene expression data for Deficiency Anemia.
Sources

Pathways for Deficiency Anemia

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Pathways related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Regulation of IFNA signaling 66
Show member pathways
 12.45 CSF3 EPO EPOR IL6 THPO
2
Insulin receptor recycling 66
Show member pathways
 12.28 CP SLC11A2 SLC40A1 TF TFRC
3
Folate Metabolism 1
Show member pathways
 12.17 ALB CRP HBB IL6
4
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.77 CSF3 EPO IL6 THPO
5
Metal ion SLC transporters 66
Show member pathways
 11.71 CP SLC11A2 SLC40A1
6
HIF-1 signaling pathway 37
11.67 EPO IL6 TF TFRC
7
Hematopoietic cell lineage 37
11.62 CSF3 EPO EPOR IL6 TFRC THPO
8
HIF-1-alpha transcription factor network 1
11.44 CP EPO TF TFRC
9
Mineral absorption 37
11.41 SLC11A2 SLC40A1 TF
10
Malaria 37
11.38 CSF3 HBB IL6
11
Differentiation Pathway 1
11.35 EPO IL6 TF
12
Hematopoietic Stem Cell Differentiation 1
11.33 CSF3 EPO IL6
13
Ferroptosis 37
11.26 CP SLC11A2 SLC40A1 TF TFRC
14
Iron metabolism in placenta 1
10.18 HAMP SLC11A2 SLC40A1 TF TFR2 TFRC
15
Hfe effect on hepcidin production 1
10.1 HAMP HFE HJV TMPRSS6
Sources

GO Terms for Deficiency Anemia

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Cellular components related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB CP CRP CSF3 EPO HAMP
2 endoplasmic reticulum lumen GO:0005788 9.76 ALB CP IL6 TF
3 early endosome GO:0005769 9.71 HFE SLC11A2 TF TFRC
4 recycling endosome GO:0055037 9.67 HFE SLC11A2 TF TFRC
5 blood microparticle GO:0072562 9.63 ALB CP HBB HBG2 TF TFRC
6 basal part of cell GO:0045178 9.5 HFE SLC11A2 TF
7 hemoglobin complex GO:0005833 9.43 HBB HBG2
8 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC
9 extracellular region GO:0005576 10.03 ALB CP CRP CSF3 EPO EPOR

Biological processes related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.93 CSF3 EPO HAMP IL6 THPO
2 cellular protein metabolic process GO:0044267 9.87 ALB CP IL6 TF
3 receptor-mediated endocytosis GO:0006898 9.83 ALB HBB TFR2 TFRC
4 transferrin transport GO:0033572 9.71 HFE TF TFR2 TFRC
5 response to iron ion GO:0010039 9.67 HAMP HFE SLC11A2 TFR2
6 acute-phase response GO:0006953 9.63 CRP EPO HAMP HFE IL6 TFR2
7 iron ion transport GO:0006826 9.62 SLC11A2 SLC40A1 TF TFR2
8 cellular response to iron ion GO:0071281 9.61 HFE TF TFR2
9 oxygen transport GO:0015671 9.59 HBB HBG2
10 copper ion transport GO:0006825 9.58 CP SLC11A2
11 erythrocyte maturation GO:0043249 9.58 EPO G6PD
12 negative regulation of lipid storage GO:0010888 9.56 CRP IL6
13 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A2 SLC40A1
14 positive regulation of peptide hormone secretion GO:0090277 9.55 HFE TFR2
15 erythropoietin-mediated signaling pathway GO:0038162 9.51 EPO EPOR
16 iron ion homeostasis GO:0055072 9.5 HFE HJV SLC11A2 SLC40A1 TF TFR2
17 iron ion import GO:0097286 9.49 TFR2 TFRC
18 regulation of iron ion import GO:1900390 9.48 HFE TF
19 response to iron ion starvation GO:1990641 9.46 HAMP HFE
20 cellular iron ion homeostasis GO:0006879 9.32 CP HAMP HFE HJV SLC11A2 SLC40A1

Molecular functions related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 CSF3 EPO IL6 THPO
2 hormone activity GO:0005179 9.65 EPO HAMP THPO
3 oxygen binding GO:0019825 9.5 ALB HBB HBG2
4 oxygen carrier activity GO:0005344 9.46 HBB HBG2
5 co-receptor binding GO:0039706 9.43 HFE TFR2
6 iron ion transmembrane transporter activity GO:0005381 9.37 SLC11A2 SLC40A1
7 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
8 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
9 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
10 transferrin receptor binding GO:1990459 8.8 HFE HJV TF
Sources

Sources for Deficiency Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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