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MCID: DFC004
MIFTS: 70

Deficiency Anemia

Categories: Blood diseases, Immune diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Deficiency Anemia

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MalaCards integrated aliases for Deficiency Anemia:

Name: Deficiency Anemia 40 12 15
Anemia 40 12 74 29 54 6 42 15 71
Deficiency Anemias 12 71
Anaemia 12 15

Classifications:

MalaCards categories:
Anatomical: Immune diseases Blood diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13121 DOID:2355
ICD9CM 34 281.9 285.9
NCIt 49 C2869
SNOMED-CT 67 267513007 271737000
UMLS 71 C0002871 C0041782
Sources

Summaries for Deficiency Anemia

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MedlinePlus : 42 If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body. Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction. Conditions that may lead to anemia include Heavy periods Pregnancy Ulcers Colon polyps or colon cancer Inherited disorders A diet that does not have enough iron, folic acid or vitamin B12 Blood disorders such as sickle cell anemia and thalassemia, or cancer Aplastic anemia, a condition that can be inherited or acquired G6PD deficiency, a metabolic disorder Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache. Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Deficiency Anemia, also known as anemia, is related to iron-refractory iron deficiency anemia and anemia, sideroblastic, 1, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Folate Metabolism and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Iron protein succinylate and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Anemia (also spelled anaemia) is a decrease in the total amount of red blood cells (RBCs) or hemoglobin... more...

Sources

Related Diseases for Deficiency Anemia

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Diseases related to Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2887)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 35.4 TMPRSS6 HJV EPO
2 anemia, sideroblastic, 1 35.3 TMPRSS6 TFRC TFR2 SLC11A2 HJV HAMP
3 anemia, congenital dyserythropoietic, type ia 35.2 TFRC HJV HAMP EPO
4 congenital dyserythropoietic anemia 35.1 TFRC HFE HAMP EPO
5 iron deficiency anemia 34.8 TNF TMPRSS6 THPO TFRC TFR2 TF
6 folic acid deficiency anemia 34.8 TFRC HAMP EPO CRP
7 cold agglutinin disease 34.0 IL6 CRP
8 iron metabolism disease 33.8 TMPRSS6 TFRC TFR2 TF SLC11A2 HJV
9 atransferrinemia 33.6 TMPRSS6 TFRC TFR2 TF SLC11A2 HJV
10 microcytic anemia 33.5 TMPRSS6 TFRC TFR2 TF SLC11A2 HJV
11 hyperferritinemia with or without cataract 33.2 TFRC TFR2 TF SLC11A2 HJV HFE
12 aceruloplasminemia 33.2 TMPRSS6 TFRC TFR2 SLC11A2 HJV HFE
13 hemoglobin h disease 33.2 TFRC TF HBA1 HAMP G6PD EPO
14 leptospirosis 33.1 TNF IL6 CRP
15 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 33.1 TFRC TFR2 TF SLC11A2 HJV HFE
16 chronic recurrent multifocal osteomyelitis 32.9 TNF IL6 CRP
17 temporal arteritis 32.8 TNF IL6 CRP
18 antiphospholipid syndrome 32.7 TNF PON1 CRP
19 iron overload in africa 32.5 TFR2 TF HJV HFE HAMP
20 hemochromatosis, type 4 32.4 TMPRSS6 TFR2 SLC11A2 HJV HFE HAMP
21 thalassemia 32.1 TMPRSS6 TFRC TFR2 TF HJV HFE
22 celiac disease 1 32.1 TNF TFRC IL6 HFE CRP
23 thrombocytosis 31.9 THPO IL6 EPO CRP
24 vitamin b12 deficiency 31.8 TF PON1 EPO
25 hypochromic microcytic anemia 31.8 TMPRSS6 TFRC TFR2 TF SLC11A2 HJV
26 beta-thalassemia 31.7 TMPRSS6 TFRC TFR2 TF HJV HFE
27 hemosiderosis 31.7 TFRC TFR2 TF SLC11A2 HJV HFE
28 chronic kidney disease 31.7 TNF TF PON1 IL6 HAMP EPO
29 kidney disease 31.6 XDH TF PON1 IL6 EPO CRP
30 hemolytic anemia 31.6 TNF TFRC TF HBA1 G6PD EPO
31 plasmodium falciparum malaria 31.6 TNF MB IL6 G6PD CRP
32 acquired immunodeficiency syndrome 31.6 TNF IL6 EPO CRP
33 thrombocytopenia 31.5 TNF THPO TFRC IL6 HIF1A EPO
34 hemoglobinopathy 31.5 TFRC TFR2 TF HJV HFE HBA1
35 chickenpox 31.4 TNF IL6 CRP
36 syphilis 31.4 TNF IL6 CRP CP
37 hemochromatosis, type 1 31.4 TMPRSS6 TFRC TFR2 TF SLC11A2 PON1
38 restless legs syndrome 31.4 TFRC SLC11A2 HIF1A EPO
39 myocardial infarction 31.4 TNF PON1 MB IL6 HIF1A HFE
40 perinatal necrotizing enterocolitis 31.4 TNF THPO IL6 CRP
41 pulmonary edema 31.3 TNF HIF1A EPO CRP
42 polycythemia 31.3 THPO TFRC HIF1A HAMP EPO
43 neonatal jaundice 31.3 TNF IL6 G6PD
44 congestive heart failure 31.3 TNF IL6 EPO CRP
45 pyelonephritis 31.3 TNF IL6 CRP
46 acute myocardial infarction 31.3 TNF MB IL6 CRP
47 angina pectoris 31.3 MB IL6 CRP
48 nutritional deficiency disease 31.3 TMPRSS6 TFRC TF IL6 HJV HAMP
49 neutropenia 31.2 TNF THPO TFRC IL6 EPO CRP
50 fasciitis 31.2 TNF IL6 CRP

Comorbidity relations with Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 323)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Acute Kidney Failure
Acute Leukemia Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Adjustment Disorder Adrenal Gland Disease
Agammaglobulinemia, X-Linked Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Alzheimer Disease
Amyloidosis Anemia, Autoimmune Hemolytic
Anus Cancer Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Asbestosis
Ascending Colon Cancer Aspergillosis
Atrioventricular Block Atrophic Gastritis
Atypical Depressive Disorder Autonomic Nervous System Disease
Bacteremia 2 Basilar Artery Insufficiency
Benign Essential Hypertension Benign Hypertensive Renal Disease
Bladder Cancer Bleeding Disorder, Platelet-Type, 11
Blepharitis Bronchiectasis
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cardiogenic Shock
Cecal Benign Neoplasm Celiac Disease 1

Graphical network of the top 20 diseases related to Deficiency Anemia:



Diseases related to Deficiency Anemia
Sources

Symptoms & Phenotypes for Deficiency Anemia

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UMLS symptoms related to Deficiency Anemia:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Deficiency Anemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 CP CRP EPO G6PD HFE HIF1A
2 cardiovascular system MP:0005385 10.27 CP CRP EPO G6PD HIF1A HJV
3 hematopoietic system MP:0005397 10.24 CP EPO G6PD HFE HIF1A HJV
4 cellular MP:0005384 10.21 CP EPO G6PD HFE HIF1A IL6
5 growth/size/body region MP:0005378 10.18 G6PD HFE HIF1A IL6 MB SLC11A2
6 immune system MP:0005387 10.13 CP CRP EPO HFE HIF1A HJV
7 integument MP:0010771 9.81 EPO HIF1A HJV IL6 SLC11A2 TFRC
8 liver/biliary system MP:0005370 9.7 CP EPO HFE HIF1A HJV IL6
9 mortality/aging MP:0010768 9.44 EPO G6PD HFE HIF1A HJV IL6
Sources

Drugs & Therapeutics for Deficiency Anemia

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Drugs for Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 897)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Iron protein succinylate Approved, Investigational Phase 4 250705-13-6
2
Warfarin Approved Phase 4 81-81-2 6691 54678486
3
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
4
Acitretin Approved Phase 4 55079-83-9, 69427-46-9 6437841
5
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
6
Chlorthalidone Approved Phase 4 77-36-1 2732
7
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
8
Halofantrine Approved Phase 4 69756-53-2 37393
9
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
10
Quinine Approved Phase 4 130-95-0 8549 3034034
11
Artesunate Approved, Investigational Phase 4 88495-63-0 6917864 5464098
12
Copper Approved, Investigational Phase 4 7440-50-8 27099
13
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
14
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
15
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
16
Cinacalcet Approved Phase 4 226256-56-0 156419
17
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
18
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
19
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
20
Nitric Oxide Approved Phase 4 10102-43-9 145068
21
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
22
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
23
Metformin Approved Phase 4 657-24-9 14219 4091
24
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
25
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
26
Polyestradiol phosphate Approved Phase 4 28014-46-2
27
Ferrous gluconate Approved Phase 4 299-29-6
28
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
29
Deferoxamine Approved, Investigational Phase 4 70-51-9 2973
30
Nevirapine Approved Phase 4 129618-40-2 4463
31
Mycophenolic acid Approved Phase 4 24280-93-1 446541
32
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
33
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
34
carbamide peroxide Approved Phase 4 124-43-6
35
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
36
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
37
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
38
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
39
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
40
Ledipasvir Approved Phase 4 1256388-51-8 67505836
41
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
42
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
43
Doxazosin Approved Phase 4 74191-85-8 3157
44
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
45
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
46
Amlodipine Approved Phase 4 88150-42-9 2162
47
Ramipril Approved Phase 4 87333-19-5 5362129
48
Atenolol Approved Phase 4 29122-68-7 2249
49
Lopinavir Approved Phase 4 192725-17-0 92727
50
Abacavir Approved, Investigational Phase 4 136470-78-5 441300 65140

Interventional clinical trials:

(show top 50) (show all 4507)
# Name Status NCT ID Phase Drugs
1 The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children Unknown status NCT01418898 Phase 4
2 A Multi-Center, Randomized, Open Label Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and Compare the Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs. Intravenous Iron Standard of Care for the Treatment of Iron Deficiency Anemia (IDA) in an Infusion Center Setting Unknown status NCT01950247 Phase 4 Injectafer;SOC
3 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
4 The Value of Iron Treatment for Postoperative Patients With Anemia: a Randomized Double Blind Controlled Trial Unknown status NCT01975272 Phase 4 Ferinject;Ferrous fumarate;Placebo for ferrous fumarate;Placebo for ferinject
5 Multicenter Randomized Open-label Controlled Study to Investigate Treatment Response of IV Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia Secondary to Inflammatory Bowel Disease or Gastric Bypass Unknown status NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
6 Randomized, Parallel Group, Clinical Trial Comparing Intravenous Iron Sucrose Versus Oral Ferrous Sulphate in the Treatment of Perioperative Iron Deficiency in Patients With Colo-Rectal Neoplasm and Iron Deficiency Anemia. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
7 Effektivität Der in Der Schwangerschaftsvorsorge routinemässig Angewandten Eisenprophylaxe Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
8 Effectiveness of Iron Supplementation in the Second Year of Life for Prevention of Iron Deficiency Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
9 A Prospective, Randomized, Double Blind, Parallel Group Study to Establish the Therapeutic Equivalence of EPIAO® With the Standard Treatment EPREX® in Subjects With Chronic Kidney Disease (CKD) Related Anaemia Not Yet on Dialysis Unknown status NCT02522975 Phase 4 EPIAO®;EPREX®
10 Predictors of Response to Treatment With Iron and Erythropoietin in Dialysis Anaemia Unknown status NCT02707757 Phase 4 Iron sucrose;Erythopoietin stimulating agent
11 Effect of Preoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty : A Randomized, Controlled, Double-Blind Trial Unknown status NCT03561506 Phase 4 Ferric carboxymaltose;0.9% Normal Saline
12 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
13 Different Doses of Anti-thymocyte Globin With 2.5 or 3.75mg/kg to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
14 Combination With Intravenous Iron Supplementation or Doubling Erythropoietin Dose for Patients With Chemotherapy-induced Anaemia Inadequately Responsive to Initial Erythropoietin Treatment Alone Unknown status NCT02731378 Phase 4 Erythropoietins (EPO);Aggressive iron dextran supplementation;Erythropoietins (EPO);Sustained iron dextran supplementation
15 Effect of Postoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty : A Randomized, Controlled, Double-Blind Trial Unknown status NCT03561480 Phase 4 Ferric carboxymaltose;0.9% Normal Saline
16 An Pilot Study to Assess the Efficacy of Intravenous Iron Isomaltoside 1000 (Monofer®) in the Management of Anaemia Associated With the Palliative Management of Oesophagogastric Adenocarcinoma Unknown status NCT01927328 Phase 4 Iron isomaltoside 1000
17 Effect of Mobile-Directly Observed Therapy (DOT) on Adherence to Hydroxyurea Treatment in Adult HbSS Patients at Muhimbili National Hospital (MNH) in Tanzania: a Pilot Study Unknown status NCT02844673 Phase 4 Hydroxyurea
18 The Impact of Treatment of Anaemia With Intravenous Iron on Haematological Values for Patients After Colorectal Surgery Unknown status NCT02999217 Phase 4 Iron isomaltoside;Saline
19 Effect of Iron Supplementation on Psychomotor Development of Non-anemic Exclusively or Predominantly Breastfed Infants: Randomized, Double-blind, Placebo-controlled Trial. Unknown status NCT02242188 Phase 4 Iron
20 Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients. A Randomized, Controlled, Double-blind Study Unknown status NCT03211286 Phase 4 Tranexamic Acid;Saline Solution
21 Megadose of Hydroxocobalamin (Vitamin B12) for the Treatment of Pernicious Anemia Unknown status NCT03372447 Phase 4 Hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg
22 Efficacy and Safety of Erythropoietin in the Treatment of Anemia in Patients With Lymphoma After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT03010579 Phase 4 erythropoietin;iron supplementation
23 Phase 4 Study on the Efficacy of Erythropoietin Treatment in Patients With Systolic Left Ventricular Dysfunction, Mild Anemia and Normal Renal Function Unknown status NCT00418119 Phase 4 erythropoietin
24 Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia Unknown status NCT01084122 Phase 4 Iron sucrose
25 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
26 A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant Papua New Guinean Women Unknown status NCT02575755 Phase 4 Azithromycin plus piperaquine phosphate;Sulfadoxine-pyrimethamine
27 Multi-center Clinical Study of Immunosuppressants, Cyclophosphamide, And Cord Blood Transfusion in Treating Patients With Severe Aplastic Anemia Unknown status NCT02838992 Phase 4 Rabbit ATG, (Genzyme);Cy;CsA
28 Moderate-dose Cyclophosphamide for Childhood Acquired Aplastic Anemia Unknown status NCT01995331 Phase 4 cyclophosphamide,cyclosporine A
29 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
30 Cluster Randomised Trial to Compare Effectiveness of the Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) to LLINs Alone for Malaria Prevention in Muleba District, Kagera Region, Tanzania Unknown status NCT01697852 Phase 4
31 Anemia Treatment in Inflammatory Bowel Disease: Predictive Factors of Response to Oral Iron Treatment Unknown status NCT02760940 Phase 4 oral liposomal iron
32 EArly Discharge After Transradial Stenting of CoronarY Arteries in High-Risk Patients of Bleeding: Bivalirudin to Reduce Bleeding EASY-B2B Study Unknown status NCT01084993 Phase 4 Bivalirudin;Heparin
33 The Effect of Intra Venus Ferric Carboxymaltose Preoperative on Hemoglobin and Blood Transfusion Post Cardiac Surgery Unknown status NCT02939794 Phase 4 Ferinject;Placebo
34 Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis Unknown status NCT00173706 Phase 4 L-Carnitine Injection
35 Open Randomized Phase IV Study on Intravenous Iron in Anemic Patients With Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
36 Child With Severe Aplastic Anemia (SAA) Therapy: the Injection of Umbilical Cord Derived Mesenchymal Stem Cells. Unknown status NCT02218437 Phase 4 MSC+ATG
37 Evaluation of the Public Health Impact and Cost Effectiveness of Seasonal Intermittent Preventive Treatment in Children in Senegal Unknown status NCT00712374 Phase 4 sulfadoxine-pyrimethamine plus amodiaquine
38 Investigation of Signal Pathway Induced by Colla Corri Asini Regulating Globin Level in Beta Thalassemia Patients With Pregnancy Anemia Unknown status NCT03392298 Phase 4 Colla corii asini
39 Intermittent Treatment With Sulfadoxine-Pyrimethamine for Malaria Control in Children: A Randomised, Double Blind, and Placebo-Controlled Clinical Trial Unknown status NCT00168948 Phase 4 Sulfadoxin (12.5) Pyrimethamine (250 mg)
40 A Multi-Center, Open-Label, Randomized, Parallel Group Study of the Efficacy and Safety of Ferrlecit in the Maintenance of Iron Stores and Serum Hemoglobin Concentration in Hemodialysis Patients Receiving Erythropoietin. Unknown status NCT00223938 Phase 4 Oral Iron;sodium ferric gluconate;sodium ferric gluconate
41 The Impact of Intermittent Preventive Malaria Treatment With Artemisinin Combination Therapy (ACT) on Hemoglobin, Malaria, Schistosomiasis, and School Attention Among Primary Schoolchildren in the Kassena-Nankana Districts, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
42 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
43 Tacrolimus Treatment for Refractory Pure Red Cell Aplasia, a Prospective Study Unknown status NCT03540472 Phase 4 tacrolimus
44 Sirolimus Treatment for Refractory Pure Red Cell Aplasia, a Prospective Study Unknown status NCT03364764 Phase 4 Sirolimus
45 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
46 A Pilot Study to Assess the Efficacy and Safety of Folic Acid and/or Vitamin B Complex on Hepatitis C Infected Patients Treated With Pegylated Interferon and Ribavirin. Unknown status NCT02150291 Phase 4 Neurobion;placebo
47 A Randomized, Double-blind, Multi-center Clinical Trial Prospectively Evaluating Iron Protein Succinylate Oral Solution in Treating Patients With Chronic Heart Failure and Iron Deficiency Unknown status NCT03344523 Phase 4 Iron protein succinylate oral solution
48 How Many Patients Are in Need of Vitamin B12 Injections? Unknown status NCT00326833 Phase 4 vitamin B12
49 Safety of Ticagrelor Plus Warfarin Versus Clopidogrel+Aspirin+Warfarin in Patients With Persistent or Permanent Atrial Fibrillation and Undergoing PCI-S: A Randomized, Open, Controlled, Parallel Group, Multi-center Trial Unknown status NCT02206815 Phase 4 Ticagrelor+Warfarin;Clopidogrel+Aspirin+Warfarin
50 A Randomized, Placebo Controlled, Double Blind Trial of the Effect of Combined Therapy With Deferoxamine and Deferiprone on Myocardial Iron in Thalassemia Major Using Cardiovascular Magnetic Resonance Unknown status NCT00103753 Phase 4 deferiprone

Search NIH Clinical Center for Deficiency Anemia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


darbepoetin alfa
Epoetin Alfa
Nandrolone
nandrolone decanoate
nandrolone phenpropionate
Oxymetholone
Sodium Ascorbate
Sources

Genetic Tests for Deficiency Anemia

About this section

Genetic tests related to Deficiency Anemia:

# Genetic test Affiliating Genes
1 Anemia 29
Sources

Anatomical Context for Deficiency Anemia

About this section

MalaCards organs/tissues related to Deficiency Anemia:

40
Kidney, Bone, Bone Marrow, Heart, Testes, Myeloid, Liver
Sources

Publications for Deficiency Anemia

About this section

Articles related to Deficiency Anemia:

(show top 50) (show all 34766)
# Title Authors PMID Year
1
Pernicious anaemia. 42
32332011 2020
2
Interpretation of vitamin B-12 and folate concentrations in population-based surveys does not require adjustment for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. 42
32266401 2020
3
Adjusting plasma or serum zinc concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. 42
32266402 2020
4
Disappearance of monosomy 7 in a patient with aplastic anemia after eltrombopag treatment. 61
32338586 2020
5
Identification of potential miRNA-mRNA interaction network in bone marrow T cells of acquired aplastic anemia. 61
32338587 2020
6
Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era. 61
32432512 2020
7
Epidemiology of aplastic anemia: a study of 1324 cases. 61
31906834 2020
8
Expression of serum BMP6 and hepcidin in cancer-related anemia. 61
32153255 2020
9
Anemia in centenarians: prevalence and association with kidney function. 61
31861969 2020
10
COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia. 61
32457227 2020
11
IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors. 61
32520308 2020
12
The relationship between maternal anemia during pregnancy with preterm birth: a systematic review and meta-analysis. 61
30522368 2020
13
Long-term Effect of Split Iron Dextran/Hemoglobin Supplementation on Erythrocyte and Iron Status, Growth Performance, Carcass Parameters, and Meat Quality of Polish Large White and 990 Line Pigs. 61
31701465 2020
14
COVID-19 in a child with severe aplastic anemia. 61
32539221 2020
15
Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ancestry children with sickle cell anemia. 61
32434137 2020
16
Hypoxia-inducible factor prolyl hydroxylase inhibitor in the treatment of anemia in chronic kidney disease. 61
32452915 2020
17
An Effective and Efficient Testing Protocol for Diagnosing Iron-deficiency Anemia Preoperatively. 61
32205552 2020
18
The Influence of Preoperative Anemia on Clinical Outcomes After Infrainguinal Bypass Surgery. 61
31863946 2020
19
Diagnosing sickle cell disease and iron deficiency anemia in human blood by Raman spectroscopy. 61
31637552 2020
20
Fatigability: A new perspective on and patient-centered outcome measure for patients with anemia. 61
32291785 2020
21
Evaluation of oxidative stress-related genetic variants for predicting stroke in patients with sickle cell anemia. 61
32344219 2020
22
Resolution of anemia and improved quality of life following laparoscopic hiatal hernia repair. 61
31399944 2020
23
MR Imaging of the Mesenteric Vasculature. 61
32471545 2020
24
Novel intronic variant in PALB2 gene and effective prevention of Fanconi anemia in family. 61
32052252 2020
25
Recurrent checkpoint inhibitor-induced warm agglutinin autoimmune hemolytic anemia in a patient with metastatic melanoma. 61
32243616 2020
26
Sirolimus for treatment of refractory primary warm autoimmune hemolytic anemia in children. 61
32220699 2020
27
Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia. 61
32389803 2020
28
The incidence of iron deficiency anemia post-Roux-en-Y gastric bypass and sleeve gastrectomy: a systematic review. 61
31485928 2020
29
Cerebral infarction and iron deficiency anemia due to uterine myoma in two middle-aged women with histidine-rich glycoprotein deficiency. 61
32361514 2020
30
High-altitude adaptations mitigate risk for hypertension and diabetes-associated anemia. 61
32324912 2020
31
Anemia and blood transfusion requirements in endoscopic sinus surgery: A propensity-matched analysis. 61
31418868 2020
32
Factors Associated with the Development of Anemia During Pregnancy After Sleeve Gastrectomy. 61
32500273 2020
33
Physiological and microvascular responses to hemoglobin concentration-targeted hemolytic anemia in rats. 61
32378976 2020
34
Sickle cell anemia in the state of Maranhão: a haplotype study. 61
32363415 2020
35
How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey. 61
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Management of anemia in patients with cancer: 2019 Italian Association of Medical Oncology (AIOM) guidelines. 61
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Spontaneous regression of twin anemia-polycythemia sequence presenting in first trimester. 61
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Cerebral Infarcts and Vasculopathy in Tanzanian Children With Sickle Cell Anemia. 61
32111561 2020
39
Molecular detection, histopathological analysis, and immunohistochemical characterization of equine infectious anemia virus in naturally infected equids. 61
32266552 2020
40
Epidemiology, molecular characterization, and recombination analysis of chicken anemia virus in Guangdong province, China. 61
32318833 2020
41
Comparative analysis of CpG islands in equine infectious anemia virus strains. 61
32239368 2020
42
Impact of ABO incompatibility on outcomes after haploidentical hematopoietic stem cell transplantation for severe aplastic anemia. 61
31932654 2020
43
Acquired Aplastic Anemia as a Clonal Disorder of Hematopoietic Stem Cells. 61
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44
Association between anemia and renal prognosis in autosomal dominant polycystic kidney disease: a retrospective study. 61
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45
Impact of Altitude-based Hemoglobin Modification on Pediatric Iron Deficiency Anemia Screening. 61
32446480 2020
46
Recurrent anemia and hematochezia: When total enteroscopy with motorized spiral enteroscopy gives the answer. 61
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47
A case series of post-transplant cyclophosphamide in unrelated donor hematopoietic transplantation for aplastic anemia. 61
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48
Middle Cerebral Artery Doppler Velocimetry for the Diagnosis of Twin Anemia Polycythemia Sequence: A Systematic Review. 61
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Association between serum magnesium and anemia in patients with chronic kidney disease. 61
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Association of anemia and SRH in older people: the SONIC study. 61
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Sources

Variations for Deficiency Anemia

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Expression for Deficiency Anemia

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Search GEO for disease gene expression data for Deficiency Anemia.
Sources

Pathways for Deficiency Anemia

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Pathways related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 12.19 XDH TNF IL6 HBA1 CRP
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.02 TNF TF IL6 HIF1A
3
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.84 TNF THPO IL6 EPO
4
HIF-1 signaling pathway 36
11.76 TFRC TF IL6 HIF1A EPO
5
Hematopoietic cell lineage 36
11.65 TNF THPO TFRC IL6 EPO
6
Malaria 36
11.41 TNF IL6 HBA1
7
Differentiation Pathway 1
11.38 TF IL6 EPO
8
HIF-1-alpha transcription factor network 1
11.37 TFRC TF HIF1A EPO CP
9
Ferroptosis 36
11.28 TFRC TF SLC11A2 CP
10
African trypanosomiasis 36
11.24 TNF IL6 HBA1
11
Overview of nanoparticle effects 1
10.89 TNF IL6 CRP
12
Effects of Nitric Oxide 1
10.48 XDH MB HBA1
13
Hfe effect on hepcidin production 1
10.1 TMPRSS6 HJV HFE HAMP
14
Iron metabolism in placenta 1
10.1 TFRC TFR2 TF SLC11A2 HAMP
Sources

GO Terms for Deficiency Anemia

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Cellular components related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 XDH TNF THPO TFRC TF PON1
2 cell surface GO:0009986 9.91 TNF TFRC TF SLC11A2 HJV EPO
3 cell GO:0005623 9.9 TMPRSS6 TFRC TFR2 TF SLC11A2 IL6
4 extracellular space GO:0005615 9.83 XDH TNF TMPRSS6 THPO TFRC TF
5 blood microparticle GO:0072562 9.77 TFRC TF PON1 HBA1 CP
6 recycling endosome GO:0055037 9.72 TNF TFRC TF SLC11A2 HFE
7 basal part of cell GO:0045178 9.58 TF SLC11A2 HFE
8 HFE-transferrin receptor complex GO:1990712 9.02 TFRC TFR2 TF HJV HFE

Biological processes related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TNF TFRC IL6 HIF1A HFE CRP
2 response to hypoxia GO:0001666 9.85 SLC11A2 MB HIF1A EPO
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 TNF IL6 EPO
4 iron ion transport GO:0006826 9.72 TFRC TFR2 TF SLC11A2 CP
5 osteoclast differentiation GO:0030316 9.69 TNF TFRC TF
6 transferrin transport GO:0033572 9.67 TFRC TFR2 TF HFE
7 positive regulation of chemokine production GO:0032722 9.65 TNF IL6 HIF1A
8 response to iron ion GO:0010039 9.65 TFR2 SLC11A2 HIF1A HFE HAMP
9 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
10 acute-phase response GO:0006953 9.63 TFR2 IL6 HFE HAMP EPO CRP
11 multicellular organismal iron ion homeostasis GO:0060586 9.61 SLC11A2 HFE HAMP
12 positive regulation of neuroinflammatory response GO:0150078 9.6 TNF IL6
13 response to salt stress GO:0009651 9.59 TNF EPO
14 positive regulation of peptide hormone secretion GO:0090277 9.58 TFR2 HFE
15 cellular response to iron ion GO:0071281 9.58 TFR2 TF HFE
16 iron ion transmembrane transport GO:0034755 9.57 TF SLC11A2
17 hemoglobin biosynthetic process GO:0042541 9.56 HIF1A EPO
18 response to iron ion starvation GO:1990641 9.54 HFE HAMP
19 regulation of iron ion transport GO:0034756 9.52 TF HFE
20 iron ion homeostasis GO:0055072 9.5 TMPRSS6 TFR2 TF SLC11A2 HJV HFE
21 cellular iron ion homeostasis GO:0006879 9.32 TMPRSS6 TFRC TFR2 TF SLC11A2 HJV

Molecular functions related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF THPO IL6 EPO
2 transferrin receptor activity GO:0004998 8.96 TFRC TFR2
3 transferrin receptor binding GO:1990459 8.8 TF HJV HFE
Sources

Sources for Deficiency Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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