Aliases & Classifications for Degenerative Disc Disease

MalaCards integrated aliases for Degenerative Disc Disease:

Name: Degenerative Disc Disease 38 12 55 15
Intervertebral Disc Degeneration 12 73
Degeneration of Lumbar Intervertebral Disc 73
Cervical Disc Degenerative Disorder 73
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 73
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:90
NCIt 50 C27156
ICD10 33 M51.3

Summaries for Degenerative Disc Disease

Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as intervertebral disc degeneration, is related to intervertebral disc disease and spondylolisthesis, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is LINC01562 (Long Intergenic Non-Protein Coding RNA 1562), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM proteoglycans. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotype is limbs/digits/tail.

Wikipedia : 76 Degenerative disc disease (DDD) describes the natural breakdown of an intervertebral disc of the spine.... more...

Related Diseases for Degenerative Disc Disease

Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 intervertebral disc disease 31.8 ASPN COL9A3 VDR
2 spondylolisthesis 30.5 BMP2 GDF5
3 osteoarthritis 30.4 ACAN ASPN GDF5 SOX9
4 spondyloepiphyseal dysplasia with congenital joint dislocations 11.3
5 aging 10.4
6 spondylosis 10.3
7 radiculopathy 10.2
8 hypochondrogenesis 10.1 ACAN ASPN
9 scoliosis, isolated 1 10.1
10 idiopathic scoliosis 10.1
11 polyradiculopathy 10.1 ACAN BMP2
12 bone disease 10.1 ACAN GDF5 VDR
13 synovial chondromatosis 10.0 BMP2 SOX9
14 arthritis 10.0
15 spondyloarthropathy 1 10.0
16 diabetes mellitus, noninsulin-dependent 10.0
17 body mass index quantitative trait locus 11 10.0
18 dermatitis, atopic 10.0
19 body mass index quantitative trait locus 10 10.0
20 bone mineral density quantitative trait locus 8 10.0
21 body mass index quantitative trait locus 14 10.0
22 bone mineral density quantitative trait locus 15 10.0
23 body mass index quantitative trait locus 18 10.0
24 body mass index quantitative trait locus 19 10.0
25 diabetes mellitus 10.0
26 hyperostosis 10.0
27 spondylolysis 10.0
28 dermatitis 10.0
29 hyperglycemia 10.0
30 nutritional deficiency disease 10.0
31 spondylitis 10.0
32 viral infectious disease 10.0
33 xp22.3 microdeletion syndrome 10.0
34 rapidly involuting congenital hemangioma 10.0
35 ischemic bone disease 10.0 ACAN BMP2
36 osteoporotic fracture 9.9
37 neurofibromatosis, type ii 9.9
38 osteoporosis 9.9
39 alkaptonuria 9.9
40 hypoascorbemia 9.9
41 body mass index quantitative trait locus 1 9.9
42 anxiety 9.9
43 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.9
44 scoliosis 9.9
45 osteomyelitis 9.9
46 cystitis 9.9
47 pancreatitis 9.9
48 notalgia paresthetica 9.9
49 depression 9.9
50 hypoxia 9.9

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease

Symptoms & Phenotypes for Degenerative Disc Disease

UMLS symptoms related to Degenerative Disc Disease:


sciatica

MGI Mouse Phenotypes related to Degenerative Disc Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 ASPN BMP2 GDF5 HIF1A SOX9 VDR

Drugs & Therapeutics for Degenerative Disc Disease

Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 160)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
4
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
5
Eplerenone Approved Phase 4 107724-20-9 443872 150310
6
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
7
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
8
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
10 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
11 Analgesics Phase 4,Phase 3,Not Applicable
12 Neurotransmitter Uptake Inhibitors Phase 4
13 Antidepressive Agents Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
15 Duloxetine Hydrochloride Phase 4
16 Dopamine Agents Phase 4
17 Psychotropic Drugs Phase 4,Not Applicable
18 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
21 Diuretics, Potassium Sparing Phase 4,Phase 3,Not Applicable
22 Hormone Antagonists Phase 4,Phase 3,Early Phase 1,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Early Phase 1,Not Applicable
24 Hormones Phase 4,Phase 3,Early Phase 1,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Narcotics Phase 4,Phase 3,Not Applicable
27 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
28 Natriuretic Agents Phase 4
29 Mineralocorticoids Phase 4
30 diuretics Phase 4
31 Mineralocorticoid Receptor Antagonists Phase 4
32
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
33
Methylprednisolone Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 83-43-2 6741
34
Lidocaine Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 137-58-6 3676
35
Prednisolone Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 50-24-8 5755
36
Prednisolone phosphate Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 302-25-0
37
Methylprednisolone hemisuccinate Approved Phase 3,Early Phase 1,Not Applicable 2921-57-5
38
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 2,Phase 1 9004-61-9 53477741
39 tannic acid Approved Phase 3,Not Applicable
40
Benzocaine Approved, Investigational Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
41
Tramadol Approved, Investigational Phase 3,Not Applicable 27203-92-5 33741
42
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
43
Ropivacaine Approved Phase 3 84057-95-4 175805 71273
44
Racepinephrine Approved Phase 3 329-65-7 838
45
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
46
Infliximab Approved Phase 3 170277-31-3
47
Prednisolone hemisuccinate Experimental Phase 3,Early Phase 1,Not Applicable 2920-86-7
48 Methylprednisolone acetate Phase 3,Early Phase 1,Not Applicable
49 Antineoplastic Agents, Hormonal Phase 3,Not Applicable
50 Anti-Arrhythmia Agents Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 327)
# Name Status NCT ID Phase Drugs
1 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Unknown status NCT02429908 Phase 4
2 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
3 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
4 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
5 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
6 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
7 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
8 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
9 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
10 Eplerenone as a Supplement to Epidural Steroid Injections Recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
11 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
12 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
13 NanoFUSE® PL Gutter PMCF Not yet recruiting NCT03751943 Phase 4
14 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
15 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
16 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
17 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
18 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Unknown status NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
19 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
20 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
21 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
22 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
23 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
24 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
25 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
26 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
27 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
28 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
29 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT02421601 Phase 3 Condoliase
30 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
31 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
32 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
33 Evaluation of Outcomes With Amniotic Fluid for Musculoskeletal Conditions Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
34 Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
35 Prospective Study of Thoracolumbar Spinal Fusion Graft Active, not recruiting NCT02297256 Phase 3
36 Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Not yet recruiting NCT03737461 Phase 2, Phase 3 Allogenic BM-MSCs Injection
37 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
38 BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes Not yet recruiting NCT03704363 Phase 3 Biosimilar Infliximab
39 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
40 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
41 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
42 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
43 Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
44 Clinical Trial of YH14618 in Patients With Degenerative Disc Disease Completed NCT02320019 Phase 2 Placebo;YH14618
45 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
46 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01158924 Phase 1, Phase 2 Intradiscal rhGDF-5
47 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01182337 Phase 1, Phase 2 Intradiscal rhGDF-5;Vehicle control
48 Intradiscal rhGDF-5 Phase I/II Clinical Trial Completed NCT00813813 Phase 1, Phase 2 Intradiscal rhGDF-5
49 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01124006 Phase 2 Intradiscal rhGDF-5
50 Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Completed NCT01513694 Phase 1, Phase 2

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

MalaCards organs/tissues related to Degenerative Disc Disease:

41
Bone, Testes, Bone Marrow, Skin, Breast, Thyroid, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Degenerative Disc Disease:

19
Intervertebral Disc
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

Articles related to Degenerative Disc Disease:

(show top 50) (show all 934)
# Title Authors Year
1
Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease. ( 30248387 )
2019
2
Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment. ( 30482711 )
2019
3
Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway. ( 30387830 )
2019
4
Comparison of the clinical effects of zero-profile anchored spacer (ROI-C) and conventional cage-plate construct for the treatment of noncontiguous bilevel of cervical degenerative disc disease (CDDD): A minimum 2-year follow-up. ( 29384883 )
2018
5
Safety of a novel modular cage for transforaminal lumbar interbody fusion - clinical cohort study in 20 patients with degenerative disc disease. ( 29956661 )
2018
6
An intervertebral disc whole organ culture system to investigate proinflammatory and degenerative disc disease condition. ( 29320615 )
2018
7
Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results. ( 29369186 )
2018
8
A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis. ( 29922449 )
2018
9
Budget impact analysis of demineralized bone matrix in combination with autograft in lumbar spinal fusion procedures for the treatment of lumbar degenerative disc disease in Spain. ( 29911913 )
2018
10
Selective Anterior Lumbar Interbody Fusion for Low Back Pain Associated with Degenerative Disc Disease versus Nonsurgical Management. ( 29529003 )
2018
11
Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease. ( 29352928 )
2018
12
Comparison of therapies in lumbar degenerative disc disease: a network meta-analysis of randomized controlled trials. ( 29542364 )
2018
13
Potential of Human Nucleus Pulposus-Like Cells Derived From Umbilical Cord to Treat Degenerative Disc Disease. ( 29490072 )
2018
14
Review of long-term outcomes of disc arthroplasty for symptomatic single level cervical degenerative disc disease. ( 29378457 )
2018
15
Clinical and radiological features of Three Reconstructive Procedures for the Surgical Management of Patients with Bi-level Cervical Degenerative Disc Disease at a Minimum Follow Up Period of Five Years: A Comparative Study. ( 29408574 )
2018
16
Comparison of Mobi-C Cervical Disc Arthroplasty Versus Fusion for the Treatment of Symptomatic Cervical Degenerative Disc Disease. ( 29524714 )
2018
17
Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy. ( 29568524 )
2018
18
Dynamic Adaptation of Vertebral Endplate and Trabecular Bone following Annular Injury in a Rat Model of Degenerative Disc Disease. ( 29886163 )
2018
19
Comparison of dynamic cervical implant versus anterior cervical discectomy and fusion for the treatment of single-level cervical degenerative disc disease: A five-year follow-up. ( 29220729 )
2018
20
Association of rs2228570 Polymorphism of Vitamin D Receptor Gene with Lumbar Degenerative Disc Disease. ( 29569696 )
2018
21
Impact of Psychiatric Comorbidities on Short-term Outcomes Following Intervention for Lumbar Degenerative Disc Disease. ( 29481379 )
2018
22
Comparison of Lumbar Total Disc Replacement With Surgical Spinal Fusion for the Treatment of Single-Level Degenerative Disc Disease: A Meta-Analysis of 5-Year Outcomes From Randomized Controlled Trials. ( 29977727 )
2018
23
Degenerative disc disease: Circular RNA reduces cell death in IVD disease. ( 29416131 )
2018
24
Comparison among perfect-CAr, zero-PAr, and plates with a cage in single-level cervical degenerative disc disease. ( 29368613 )
2018
25
Degenerative Disc Disease Mimicking Spondylodiscitis with Bilateral Psoas Abscesses. ( 30149157 )
2018
26
Secondary Surgery after Cervical Disc Arthroplasty versus Fusion for Cervical Degenerative Disc Disease: A Meta-analysis with Trial Sequential Analysis. ( 30152612 )
2018
27
Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris. ( 30155445 )
2018
28
Correction to: Total disc replacement versus fusion for lumbar degenerative disc disease: a systematic review of overlapping meta-analyses. ( 30196419 )
2018
29
Claw sign: MRI of degenerative disc disease. ( 30309176 )
2018
30
A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease - A Hypothesis. ( 30332977 )
2018
31
Concurrent notalgia paresthetica and brachioradial pruritus associated with cervical degenerative disc disease. ( 30372709 )
2018
32
Sagittal alignment assessment after short-segment lumbar fusion for degenerative disc disease. ( 30392043 )
2018
33
A comparison of cervical disc arthroplasty and anterior cervical discectomy and fusion in patients with two-level cervical degenerative disc disease: 5-year follow-up results. ( 30415055 )
2018
34
NTG-101: A Novel Molecular Therapy that Halts the Progression of Degenerative Disc Disease. ( 30429487 )
2018
35
Effects of three common lumbar interbody fusion procedures for degenerative disc disease: A network meta-analysis of prospective studies. ( 30471365 )
2018
36
Artificial disc replacement versus fusion in patients with cervical degenerative disc disease with radiculopathy: 5-year outcomes from the National Swedish Spine Register. ( 30485205 )
2018
37
Multilevel Lumbar Fusion Is a Risk Factor for Lower Return to Work Rates Among Workers' Compensation Subjects With Degenerative Disc Disease. ( 30489246 )
2018
38
Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials. ( 30498909 )
2018
39
The relevance of high-intensity zones in degenerative disc disease. ( 30506087 )
2018
40
Intervertebral Disc Degeneration During Postoperative Follow-up More Than 10 Years After Corrective Surgery in Idiopathic Scoliosis: Comparison Between Patients With and Without Surgery. ( 28678107 )
2018
41
Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice. ( 30201052 )
2018
42
Leptin and the intervertebral disc: a biochemical link exists between obesity, intervertebral disc degeneration and low back pain-an in vitro study in a bovine model. ( 30324498 )
2018
43
Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor α. ( 29529124 )
2018
44
Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats. ( 29535780 )
2018
45
Dysregulated MiR-3150a-3p Promotes Lumbar Intervertebral Disc Degeneration by Targeting Aggrecan. ( 29554650 )
2018
46
Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review. ( 29567950 )
2018
47
Novel stepwise model of intervertebral disc degeneration with intact annulus fibrosus to test regeneration strategies. ( 29603340 )
2018
48
A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. ( 29605718 )
2018
49
Association of IL10 and TGFB single nucleotide polymorphisms with intervertebral disc degeneration in Iranian population: a case control study. ( 29636026 )
2018
50
Quantitative magnetic resonance imaging for diagnosis of intervertebral disc degeneration of the cervico-thoracic junction: a pilot study. ( 29636882 )
2018

Variations for Degenerative Disc Disease

Expression for Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for Degenerative Disc Disease

Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 ACAN ASPN BMP2 COL9A3 GDF5
2 10.56 ACAN ASPN COL9A3

GO Terms for Degenerative Disc Disease

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.77 BMP2 HIF1A MIR132 SOX9 VDR
2 negative regulation of gene expression GO:0010629 9.71 BMP2 HIF1A MIR132 SOX9
3 positive regulation of epithelial cell migration GO:0010634 9.57 HIF1A SOX9
4 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.56 BMP2 HIF1A
5 skeletal system development GO:0001501 9.56 ACAN BMP2 SOX9 VDR
6 negative regulation of ossification GO:0030279 9.55 HIF1A SOX9
7 positive regulation of chondrocyte differentiation GO:0032332 9.54 GDF5 SOX9
8 cartilage condensation GO:0001502 9.52 ACAN SOX9
9 negative regulation of chondrocyte differentiation GO:0032331 9.51 GDF5 SOX9
10 chondrocyte differentiation GO:0002062 9.5 BMP2 GDF5 SOX9
11 chondrocyte development GO:0002063 9.49 ACAN SOX9
12 endocardial cushion morphogenesis GO:0003203 9.48 BMP2 SOX9
13 positive regulation of cartilage development GO:0061036 9.46 BMP2 SOX9
14 negative regulation of bone mineralization GO:0030502 9.43 HIF1A SOX9
15 epithelial to mesenchymal transition GO:0001837 9.33 BMP2 HIF1A SOX9
16 cartilage development GO:0051216 9.26 BMP2 GDF5 HIF1A SOX9
17 negative regulation of mesenchymal cell apoptotic process GO:2001054 8.8 GDF5 HIF1A SOX9

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.62 ACAN ASPN

Sources for Degenerative Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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