Aliases & Classifications for Degenerative Disc Disease

MalaCards integrated aliases for Degenerative Disc Disease:

Name: Degenerative Disc Disease 38 12 55 15
Intervertebral Disc Degeneration 12 73
Degeneration of Lumbar Intervertebral Disc 73
Cervical Disc Degenerative Disorder 73
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 73
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:90
NCIt 50 C27156
SNOMED-CT 68 156633005
ICD10 33 M51.3

Summaries for Degenerative Disc Disease

Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as intervertebral disc degeneration, is related to intervertebral disc disease and spondylolisthesis, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is LINC01562 (Long Intergenic Non-Protein Coding RNA 1562
Up-regulated RP11-296A18.3 highly likely induced the over expression of FAF1, which eventually promoted the aberrant apoptosis of disc cells
Dysfunction Pattern: Expression), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM proteoglycans. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotype is limbs/digits/tail.

Wikipedia : 76 Degenerative disc disease (DDD) describes the natural breakdown of an intervertebral disc of the spine.... more...

Related Diseases for Degenerative Disc Disease

Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 intervertebral disc disease 31.2 ASPN COL9A3 VDR
2 spondylolisthesis 30.6 BMP2 GDF5
3 osteoarthritis 30.3 ACAN ASPN GDF5 SOX9
4 back pain 30.0 ASPN COL9A3 COMT
5 cervicitis 10.7
6 hypochondrogenesis 10.4 ACAN ASPN
7 polyradiculopathy 10.3 ACAN BMP2
8 bone disease 10.2 ACAN GDF5 VDR
9 synovial chondromatosis 10.2 BMP2 SOX9
10 brachydactyly, type a2 10.1 BMP2 GDF5
11 radiculopathy 10.1
12 arthritis 9.9
13 proximal symphalangism 9.9 BMP2 GDF5
14 breast cancer 9.8
15 hypoascorbemia 9.8
16 aging 9.8
17 body mass index quantitative trait locus 1 9.8
18 anxiety 9.8
19 scoliosis 9.8
20 osteomyelitis 9.8
21 cystitis 9.8
22 pancreatitis 9.8
23 thyroiditis 9.8
24 depression 9.8
25 osteochondrosis 9.7
26 ischemic bone disease 9.7 ACAN BMP2
27 bone deterioration disease 8.8 ACAN BMP2 COL9A3 GDF5 SOX9
28 bone structure disease 8.8 ACAN BMP2 COL9A3 GDF5 SOX9

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease

Symptoms & Phenotypes for Degenerative Disc Disease

UMLS symptoms related to Degenerative Disc Disease:


sciatica

MGI Mouse Phenotypes related to Degenerative Disc Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 ASPN BMP2 GDF5 HIF1A SOX9 VDR

Drugs & Therapeutics for Degenerative Disc Disease

Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
4
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
5
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
6
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
7
Eplerenone Approved Phase 4 107724-20-9 150310 443872
8 Analgesics Phase 4,Phase 3,Not Applicable
9
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
12 Neurotransmitter Agents Phase 4,Not Applicable
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
15 Hormone Antagonists Phase 4,Phase 3,Not Applicable
16 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
17 Hormones Phase 4,Phase 3,Not Applicable
18 Diuretics, Potassium Sparing Phase 4,Phase 3,Not Applicable
19 Dopamine Agents Phase 4
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
21 Duloxetine Hydrochloride Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Antidepressive Agents Phase 4
24 Psychotropic Drugs Phase 4,Not Applicable
25 Narcotics Phase 4,Phase 3,Not Applicable
26 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
27 diuretics Phase 4
28 Mineralocorticoid Receptor Antagonists Phase 4
29 Mineralocorticoids Phase 4
30 Natriuretic Agents Phase 4
31
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
32
Lidocaine Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 137-58-6 3676
33
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 2,Phase 1 9004-61-9 53477741
34
Prednisolone Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 50-24-8 5755
35
Methylprednisolone Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 83-43-2 6741
36
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
37
Tramadol Approved, Investigational Phase 3,Not Applicable 27203-92-5 33741
38
Benzocaine Approved, Investigational Phase 3,Phase 1 1994-09-7, 94-09-7 2337
39 tannic acid Approved, Nutraceutical Phase 3,Phase 1
40 Prednisolone acetate Phase 3,Early Phase 1,Not Applicable
41 glucocorticoids Phase 3,Not Applicable
42 Methylprednisolone acetate Phase 3,Early Phase 1,Not Applicable
43 Methylprednisolone Hemisuccinate Phase 3,Early Phase 1,Not Applicable
44 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
45 Gastrointestinal Agents Phase 3,Not Applicable
46 Sodium Channel Blockers Phase 3,Not Applicable
47 Neuroprotective Agents Phase 3,Not Applicable
48 Anti-Arrhythmia Agents Phase 3,Not Applicable
49 Viscosupplements Phase 3,Phase 2,Phase 1
50 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 308)
# Name Status NCT ID Phase Drugs
1 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Unknown status NCT02429908 Phase 4
2 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
3 Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™ Unknown status NCT02425514 Phase 4
4 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
5 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
6 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
7 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
8 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
9 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
10 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
11 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
12 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
13 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
14 Eplerenone as a Supplement to Epidural Steroid Injections Not yet recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
15 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
16 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
17 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease Unknown status NCT00589797 Phase 3
18 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
19 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
20 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Unknown status NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
21 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
22 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
23 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
24 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
25 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
26 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
27 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
28 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
29 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
30 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
31 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT02421601 Phase 3 Condoliase
32 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
33 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
34 Evaluation of Outcomes With Amniotic Fluid for Musculoskeletal Conditions Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
35 Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
36 Prospective Study of Thoracolumbar Spinal Fusion Graft Active, not recruiting NCT02297256 Phase 3
37 Restore CLINICAL TRIAL Active, not recruiting NCT01609374 Phase 3
38 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
39 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Not yet recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
40 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
41 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
42 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
43 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
44 Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
45 Clinical Trial of YH14618 in Patients With Degenerative Disc Disease Completed NCT02320019 Phase 2 Placebo;YH14618
46 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
47 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01158924 Phase 1, Phase 2 Intradiscal rhGDF-5
48 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01182337 Phase 1, Phase 2 Intradiscal rhGDF-5;Vehicle control
49 Intradiscal rhGDF-5 Phase I/II Clinical Trial Completed NCT00813813 Phase 1, Phase 2 Intradiscal rhGDF-5
50 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degenerat Completed NCT01124006 Phase 2 Intradiscal rhGDF-5

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Degenerative Disc Disease:

19
Intervertebral Disc

MalaCards organs/tissues related to Degenerative Disc Disease:

41
Bone, Bone Marrow, Testes, Spinal Cord, Thyroid, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

Articles related to Degenerative Disc Disease:

(show top 50) (show all 348)
# Title Authors Year
1
Comparison of the clinical effects of zero-profile anchored spacer (ROI-C) and conventional cage-plate construct for the treatment of noncontiguous bilevel of cervical degenerative disc disease (CDDD): A minimum 2-year follow-up. ( 29384883 )
2018
2
Safety of a novel modular cage for transforaminal lumbar interbody fusion - clinical cohort study in 20 patients with degenerative disc disease. ( 29956661 )
2018
3
An intervertebral disc whole organ culture system to investigate proinflammatory and degenerative disc disease condition. ( 29320615 )
2018
4
Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results. ( 29369186 )
2018
5
A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis. ( 29922449 )
2018
6
Budget impact analysis of demineralized bone matrix in combination with autograft in lumbar spinal fusion procedures for the treatment of lumbar degenerative disc disease in Spain. ( 29911913 )
2018
7
Selective Anterior Lumbar Interbody Fusion for Low Back Pain Associated with Degenerative Disc Disease versus Nonsurgical Management. ( 29529003 )
2018
8
Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease. ( 29352928 )
2018
9
Comparison of therapies in lumbar degenerative disc disease: a network meta-analysis of randomized controlled trials. ( 29542364 )
2018
10
Potential of Human Nucleus Pulposus-Like Cells Derived From Umbilical Cord to Treat Degenerative Disc Disease. ( 29490072 )
2018
11
Review of long-term outcomes of disc arthroplasty for symptomatic single level cervical degenerative disc disease. ( 29378457 )
2018
12
Clinical and radiological features of Three Reconstructive Procedures for the Surgical Management of Patients with Bi-level Cervical Degenerative Disc Disease at a Minimum Follow Up Period of Five Years: A Comparative Study. ( 29408574 )
2018
13
Comparison of Mobi-C Cervical Disc Arthroplasty Versus Fusion for the Treatment of Symptomatic Cervical Degenerative Disc Disease. ( 29524714 )
2018
14
Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy. ( 29568524 )
2018
15
Dynamic Adaptation of Vertebral Endplate and Trabecular Bone following Annular Injury in a Rat Model of Degenerative Disc Disease. ( 29886163 )
2018
16
Comparison of dynamic cervical implant versus anterior cervical discectomy and fusion for the treatment of single-level cervical degenerative disc disease: A five-year follow-up. ( 29220729 )
2018
17
Association of rs2228570 Polymorphism of Vitamin D Receptor Gene with Lumbar Degenerative Disc Disease. ( 29569696 )
2018
18
Impact of Psychiatric Comorbidities on Short-term Outcomes Following Intervention for Lumbar Degenerative Disc Disease. ( 29481379 )
2018
19
Comparison of Lumbar Total Disc Replacement With Surgical Spinal Fusion for the Treatment of Single-Level Degenerative Disc Disease: A Meta-Analysis of 5-Year Outcomes From Randomized Controlled Trials. ( 29977727 )
2018
20
Degenerative disc disease: Circular RNA reduces cell death in IVD disease. ( 29416131 )
2018
21
Comparison among perfect-CAr, zero-PAr, and plates with a cage in single-level cervical degenerative disc disease. ( 29368613 )
2018
22
Indirect meta-analysis comparing clinical outcomes of total cervical disc replacements with fusions for cervical degenerative disc disease. ( 28496111 )
2017
23
Does Obesity Affect Perioperative and Postoperative Morbidity and Complication Rates After Minimal Access Spinal Technologies in Surgery for Lumbar Degenerative Disc Disease. ( 29274450 )
2017
24
Atherosclerotic Disease and its Relationship to Lumbar Degenerative Disc Disease, Facet Arthritis and Stenosis with Computed Tomography Angiography. ( 28918116 )
2017
25
Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus. ( 28358123 )
2017
26
Efficacy and safety of Mobi-C cervical artificial disc versus anterior discectomy and fusion in patients with symptomatic degenerative disc disease: A meta-analysis. ( 29245217 )
2017
27
Surgical and Functional Outcomes After Multilevel Cervical Fusion for Degenerative Disc Disease Compared With Fusion for Radiculopathy: A Study of Workers' Compensation Population. ( 28441686 )
2017
28
Pain drawings predict outcome of surgical treatment for degenerative disc disease in the cervical spine. ( 28718697 )
2017
29
Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease. ( 28894792 )
2017
30
Hybrid Bone Single Photon Emission Computed Tomography Imaging in Evaluation of Chronic Low Back Pain: Correlation with Modic Changes and Degenerative Disc Disease. ( 28377243 )
2017
31
Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. ( 28938891 )
2017
32
The Concurrent Use of Lumbar Total Disc Arthroplasty and Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure for the Treatment of Multi-Level Symptomatic Degenerative Disc Disease- A Prospective Study. ( 28598895 )
2017
33
Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. ( 27902945 )
2017
34
Anxiety and depression affect pain drawings in cervical degenerative disc disease. ( 28503982 )
2017
35
Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease. ( 28086781 )
2017
36
The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine. ( 28670401 )
2017
37
Comparison of Outcomes of Single-Level Anterior Cervical Discectomy With Fusion and Single-Level Artificial Cervical Disc Replacement for Single-Level Cervical Degenerative Disc Disease. ( 28002363 )
2017
38
Chemometric evaluation of concentrations of trace elements in intervertebral disc tissue in patient with degenerative disc disease. ( 29284234 )
2017
39
A comparison of anterior cervical discectomy and fusion combined with cervical disc arthroplasty and cervical disc arthroplasty for the treatment of skip-level cervical degenerative disc disease: A retrospective study. ( 29019878 )
2017
40
The usefulness of radiological grading scales to predict pain intensity, functional impairment, and health-related quality of life after surgery for lumbar degenerative disc disease. ( 27873048 )
2017
41
Cervical sagittal alignment after different anterior discectomy procedures for single-level cervical degenerative disc disease: randomized controlled trial. ( 28887690 )
2017
42
Comparison of lumbar pedicular dynamic stabilisation systems versus fusion for the treatment of lumbar degenerative disc disease: A meta-analysis. ( 29322911 )
2017
43
Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up. ( 28748380 )
2017
44
Objective Functional Testing in Patients With Lumbar Degenerative Disc Disease. ( 28815166 )
2017
45
Clinical Outcomes of Total Disc Replacement Versus Anterior Lumbar Interbody Fusion for Surgical Treatment of Lumbar Degenerative Disc Disease. ( 28811990 )
2017
46
Trends analysis of surgical procedures for cervical degenerative disc disease and myelopathy in patients with tobacco use disorder. ( 28488093 )
2017
47
Identifying subsets of patients with single-level degenerative disc disease for lumbar fusion: the value of prognostic tests in surgical decision making. ( 28890222 )
2017
48
Kinematic characteristics of lumbar spinous processes during axial rotation in patients with lumbar degenerative disc disease lateral lumbar interbody fusion and intervention. ( 28376780 )
2017
49
Cost Utility Analysis of the Cervical Artificial Disc vs Fusion for the Treatment of 2-Level Symptomatic Degenerative Disc Disease: 5-Year Follow-up. ( 26855020 )
2016
50
A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolutiona8c) with a comparison to historical controls. ( 26849141 )
2016

Variations for Degenerative Disc Disease

Expression for Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for Degenerative Disc Disease

Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 ACAN ASPN BMP2 COL9A3 GDF5
2 10.56 ACAN ASPN COL9A3

GO Terms for Degenerative Disc Disease

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.77 BMP2 HIF1A MIR132 SOX9 VDR
2 negative regulation of gene expression GO:0010629 9.71 BMP2 HIF1A MIR132 SOX9
3 skeletal system development GO:0001501 9.56 ACAN BMP2 SOX9 VDR
4 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.54 BMP2 HIF1A
5 negative regulation of ossification GO:0030279 9.52 HIF1A SOX9
6 positive regulation of chondrocyte differentiation GO:0032332 9.51 GDF5 SOX9
7 chondrocyte differentiation GO:0002062 9.5 BMP2 GDF5 SOX9
8 negative regulation of chondrocyte differentiation GO:0032331 9.49 GDF5 SOX9
9 endocardial cushion morphogenesis GO:0003203 9.48 BMP2 SOX9
10 positive regulation of cartilage development GO:0061036 9.46 BMP2 SOX9
11 negative regulation of bone mineralization GO:0030502 9.43 HIF1A SOX9
12 epithelial to mesenchymal transition GO:0001837 9.33 BMP2 HIF1A SOX9
13 cartilage development GO:0051216 9.26 BMP2 GDF5 HIF1A SOX9
14 negative regulation of mesenchymal cell apoptotic process GO:2001054 8.8 GDF5 HIF1A SOX9

Sources for Degenerative Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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