Aliases & Classifications for Degenerative Disc Disease

MalaCards integrated aliases for Degenerative Disc Disease:

Name: Degenerative Disc Disease 39 12 56 15
Cervical Disc Degenerative Disorder 17 74
Intervertebral Disc Degeneration 12 74
Degeneration of Lumbar Intervertebral Disc 74
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 74
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:90
NCIt 51 C27156
ICD10 34 M51.3

Summaries for Degenerative Disc Disease

Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as cervical disc degenerative disorder, is related to intervertebral disc disease and spondylolisthesis, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is LINC01562 (Long Intergenic Non-Protein Coding RNA 1562), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM proteoglycans. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotype is limbs/digits/tail.

Wikipedia : 77 Degenerative disc disease (DDD) is a medical condition (ICD-10-CM M51.35-37) in which there are anatomic... more...

Related Diseases for Degenerative Disc Disease

Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 intervertebral disc disease 31.8 ASPN COL9A3 VDR
2 spondylolisthesis 30.5 BMP2 GDF5
3 osteoarthritis 30.4 ACAN ASPN GDF5 SOX9
4 spondyloepiphyseal dysplasia with congenital joint dislocations 11.3
5 loeys-dietz syndrome 3 11.3
6 aging 10.5
7 radiculopathy 10.3
8 bone mineral density quantitative trait locus 8 10.3
9 bone mineral density quantitative trait locus 15 10.3
10 spondylosis 10.3
11 hypercalcemia, infantile, 1 10.2 CALCA VDR
12 diabetes mellitus 10.2
13 hypochondrogenesis 10.2 ACAN ASPN
14 polyradiculopathy 10.1 ACAN BMP2
15 scoliosis, isolated 1 10.1
16 idiopathic scoliosis 10.1
17 synovial chondromatosis 10.0 BMP2 SOX9
18 spondyloarthropathy 1 10.0
19 body mass index quantitative trait locus 11 10.0
20 dermatitis, atopic 10.0
21 body mass index quantitative trait locus 8 10.0
22 body mass index quantitative trait locus 10 10.0
23 body mass index quantitative trait locus 7 10.0
24 body mass index quantitative trait locus 14 10.0
25 body mass index quantitative trait locus 18 10.0
26 body mass index quantitative trait locus 19 10.0
27 hyperostosis 10.0
28 spondylolysis 10.0
29 iron metabolism disease 10.0
30 dermatitis 10.0
31 hyperglycemia 10.0
32 spondylitis 10.0
33 xp22.3 microdeletion syndrome 10.0
34 rapidly involuting congenital hemangioma 10.0
35 bone disease 10.0 ACAN CALCA GDF5 VDR
36 bone resorption disease 10.0 BMP2 CALCA VDR
37 secondary hyperparathyroidism of renal origin 10.0 CALCA VDR
38 bone remodeling disease 10.0 BMP2 CALCA VDR
39 exostosis 9.9
40 osteoporotic fracture 9.9
41 glucocorticoid-induced osteoporosis 9.9 BMP2 CALCA
42 neurofibromatosis, type ii 9.9
43 breast cancer 9.9
44 osteoporosis 9.9
45 alkaptonuria 9.9
46 hypoascorbemia 9.9
47 body mass index quantitative trait locus 1 9.9
48 anxiety 9.9
49 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.9
50 arthritis 9.9

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease

Symptoms & Phenotypes for Degenerative Disc Disease

UMLS symptoms related to Degenerative Disc Disease:


sciatica

MGI Mouse Phenotypes related to Degenerative Disc Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 BMP2 GDF5 HIF1A SOX9 VDR

Drugs & Therapeutics for Degenerative Disc Disease

Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
4
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
5
Eplerenone Approved Phase 4 107724-20-9 443872 150310
6
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 38396-39-3, 2180-92-9 2474
7 Dopamine Agents Phase 4
8 Duloxetine Hydrochloride Phase 4
9 Antidepressive Agents Phase 4
10 Neurotransmitter Uptake Inhibitors Phase 4
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Psychotropic Drugs Phase 4,Not Applicable
13 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
14 Analgesics Phase 4,Phase 3,Not Applicable
15 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
16
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Hormone Antagonists Phase 4,Phase 3,Early Phase 1,Not Applicable
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Early Phase 1,Not Applicable
22 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
23 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
26 Narcotics Phase 4,Phase 3,Not Applicable
27 diuretics Phase 4
28 Antihypertensive Agents Phase 4,Not Applicable
29 Natriuretic Agents Phase 4
30 Mineralocorticoid Receptor Antagonists Phase 4
31 Mineralocorticoids Phase 4
32
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
33
Methylprednisolone hemisuccinate Approved Phase 3,Early Phase 1,Not Applicable 2921-57-5
34
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Early Phase 1,Not Applicable 137-58-6 3676
35
Methylprednisolone Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 83-43-2 6741
36
Prednisolone Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 50-24-8 5755
37
Prednisolone phosphate Approved, Vet_approved Phase 3,Early Phase 1,Not Applicable 302-25-0
38
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 2,Phase 1 9004-61-9 53477741
39
tannic acid Approved Phase 3,Not Applicable 1401-55-4
40
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
41
Tramadol Approved, Investigational Phase 3,Not Applicable 27203-92-5 33741
42
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 644073 40400
43
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
44
Racepinephrine Approved Phase 3 329-65-7 838
45
Ropivacaine Approved Phase 3 84057-95-4 175805 71273
46
Infliximab Approved Phase 3 170277-31-3
47
Calcium Approved, Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable 7440-70-2 271
48
Prednisolone hemisuccinate Experimental Phase 3,Early Phase 1,Not Applicable 2920-86-7
49 Protective Agents Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
50 glucocorticoids Phase 3,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 343)
# Name Status NCT ID Phase Drugs
1 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
2 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
3 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
4 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
5 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
6 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
7 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
8 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
9 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
10 Eplerenone as a Supplement to Epidural Steroid Injections Recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
11 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
12 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
13 NanoFUSE® PL Gutter PMCF Not yet recruiting NCT03751943 Phase 4
14 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
15 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
16 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
17 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
18 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Unknown status NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
19 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
20 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
21 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
22 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
23 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
24 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
25 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
26 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
27 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
28 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
29 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT02421601 Phase 3 Condoliase
30 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
31 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
32 Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Recruiting NCT03737461 Phase 2, Phase 3 Allogenic BM-MSCs Injection
33 Peri-Incisional Drug Injection in Lumbar Spine Surgery Recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
34 BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes Recruiting NCT03704363 Phase 3 Biosimilar Infliximab
35 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
36 Evaluation of Outcomes With Amniotic Fluid for Musculoskeletal Conditions Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
37 Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
38 Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT Enrolling by invitation NCT03884283 Phase 3
39 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
40 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
41 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
42 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
43 Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
44 Clinical Trial of YH14618 in Patients With Degenerative Disc Disease Completed NCT02320019 Phase 2 Placebo;YH14618
45 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
46 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01158924 Phase 1, Phase 2 Intradiscal rhGDF-5
47 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01182337 Phase 1, Phase 2 Intradiscal rhGDF-5;Vehicle control
48 Intradiscal rhGDF-5 Phase I/II Clinical Trial Completed NCT00813813 Phase 1, Phase 2 Intradiscal rhGDF-5
49 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01124006 Phase 2 Intradiscal rhGDF-5
50 Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Completed NCT01513694 Phase 1, Phase 2

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

MalaCards organs/tissues related to Degenerative Disc Disease:

42
Bone, Bone Marrow, Testes, Breast, Spinal Cord, Skin, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Degenerative Disc Disease:

20
Intervertebral Disc
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

Articles related to Degenerative Disc Disease:

(show top 50) (show all 385)
# Title Authors Year
1
Potential of Human Nucleus Pulposus-Like Cells Derived From Umbilical Cord to Treat Degenerative Disc Disease. ( 29490072 )
2019
2
Association of rs2228570 Polymorphism of Vitamin D Receptor Gene with Lumbar Degenerative Disc Disease. ( 29569696 )
2019
3
Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease. ( 30248387 )
2019
4
A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease: A Hypothesis. ( 30332977 )
2019
5
Sagittal alignment assessment after short-segment lumbar fusion for degenerative disc disease. ( 30392043 )
2019
6
A Comparison of Cervical Disc Arthroplasty and Anterior Cervical Discectomy and Fusion in Patients with Two-Level Cervical Degenerative Disc Disease: 5-Year Follow-Up Results. ( 30415055 )
2019
7
Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment. ( 30482711 )
2019
8
Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials. ( 30498909 )
2019
9
The relevance of high-intensity zones in degenerative disc disease. ( 30506087 )
2019
10
Evidence-based use of arthroplasty in cervical degenerative disc disease. ( 30623197 )
2019
11
Artificial disc replacement versus fusion in patients with cervical degenerative disc disease and radiculopathy: a randomized controlled trial with 5-year outcomes. ( 30641852 )
2019
12
Percutaneous transforaminal endoscopic discectomy in the treatment of senior patients with lumbar degenerative disc disease. ( 30651875 )
2019
13
In Vivo analysis of spinopelvic kinematics and peak head-cup contact in total hip arthroplasty patients with lumbar degenerative disc disease. ( 30690800 )
2019
14
NF-κB-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease. ( 30717434 )
2019
15
T2 mapping of lumbosacral nerves in patients suffering from unilateral radicular pain due to degenerative disc disease. ( 30797199 )
2019
16
Cervical Artificial Disc Replacement Versus Fusion for Cervical Degenerative Disc Disease: A Health Technology Assessment. ( 30847009 )
2019
17
9.4T MRI Assessment of Degenerative Disc Disease: Statistical Methodology. ( 30883452 )
2019
18
Methodological issue on reliability of 9.4T MRI in the assessment of degenerative disc disease compared to 3T MRI. ( 30896587 )
2019
19
Concurrent Use of Lumbar Total Disc Arthroplasty and Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure for the Treatment of Multilevel Symptomatic Degenerative Disc Disease: A Prospective Study. ( 28598895 )
2018
20
Identifying subsets of patients with single-level degenerative disc disease for lumbar fusion: the value of prognostic tests in surgical decision making. ( 28890222 )
2018
21
Comparison of dynamic cervical implant versus anterior cervical discectomy and fusion for the treatment of single-level cervical degenerative disc disease: A five-year follow-up. ( 29220729 )
2018
22
Does Obesity Affect Perioperative and Postoperative Morbidity and Complication Rates After Minimal Access Spinal Technologies in Surgery for Lumbar Degenerative Disc Disease. ( 29274450 )
2018
23
An intervertebral disc whole organ culture system to investigate proinflammatory and degenerative disc disease condition. ( 29320615 )
2018
24
Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease. ( 29352928 )
2018
25
Comparison among perfect-C®, zero-P®, and plates with a cage in single-level cervical degenerative disc disease. ( 29368613 )
2018
26
Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results. ( 29369186 )
2018
27
Review of long-term outcomes of disc arthroplasty for symptomatic single level cervical degenerative disc disease. ( 29378457 )
2018
28
Comparison of the clinical effects of zero-profile anchored spacer (ROI-C) and conventional cage-plate construct for the treatment of noncontiguous bilevel of cervical degenerative disc disease (CDDD): A minimum 2-year follow-up. ( 29384883 )
2018
29
Clinical and Radiologic Features of 3 Reconstructive Procedures for the Surgical Management of Patients with Bilevel Cervical Degenerative Disc Disease at a Minimum Follow-Up Period of 5 Years: A Comparative Study. ( 29408574 )
2018
30
Degenerative disc disease: Circular RNA reduces cell death in IVD disease. ( 29416131 )
2018
31
Impact of Psychiatric Comorbidities on Short-Term Outcomes Following Intervention for Lumbar Degenerative Disc Disease. ( 29481379 )
2018
32
Comparison of Mobi-C Cervical Disc Arthroplasty Versus Fusion for the Treatment of Symptomatic Cervical Degenerative Disc Disease. ( 29524714 )
2018
33
Selective Anterior Lumbar Interbody Fusion for Low Back Pain Associated With Degenerative Disc Disease Versus Nonsurgical Management. ( 29529003 )
2018
34
Comparison of therapies in lumbar degenerative disc disease: a network meta-analysis of randomized controlled trials. ( 29542364 )
2018
35
Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy. ( 29568524 )
2018
36
Dynamic adaptation of vertebral endplate and trabecular bone following annular injury in a rat model of degenerative disc disease. ( 29886163 )
2018
37
Budget impact analysis of demineralized bone matrix in combination with autograft in lumbar spinal fusion procedures for the treatment of lumbar degenerative disc disease in Spain. ( 29911913 )
2018
38
A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis. ( 29922449 )
2018
39
Safety of a novel modular cage for transforaminal lumbar interbody fusion - clinical cohort study in 20 patients with degenerative disc disease. ( 29956661 )
2018
40
Comparison of Lumbar Total Disc Replacement With Surgical Spinal Fusion for the Treatment of Single-Level Degenerative Disc Disease: A Meta-Analysis of 5-Year Outcomes From Randomized Controlled Trials. ( 29977727 )
2018
41
Degenerative Disc Disease Mimicking Spondylodiscitis with Bilateral Psoas Abscesses. ( 30149157 )
2018
42
Secondary Surgery after Cervical Disc Arthroplasty versus Fusion for Cervical Degenerative Disc Disease: A Meta-analysis with Trial Sequential Analysis. ( 30152612 )
2018
43
Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris. ( 30155445 )
2018
44
Correction to: Total disc replacement versus fusion for lumbar degenerative disc disease: a systematic review of overlapping meta-analyses. ( 30196419 )
2018
45
Claw sign: MRI of degenerative disc disease. ( 30309176 )
2018
46
Concurrent notalgia paresthetica and brachioradial pruritus associated with cervical degenerative disc disease. ( 30372709 )
2018
47
NTG-101: A Novel Molecular Therapy that Halts the Progression of Degenerative Disc Disease. ( 30429487 )
2018
48
Effects of three common lumbar interbody fusion procedures for degenerative disc disease: A network meta-analysis of prospective studies. ( 30471365 )
2018
49
Artificial disc replacement versus fusion in patients with cervical degenerative disc disease with radiculopathy: 5-year outcomes from the National Swedish Spine Register. ( 30485205 )
2018
50
Multilevel Lumbar Fusion Is a Risk Factor for Lower Return to Work Rates Among Workers' Compensation Subjects With Degenerative Disc Disease. ( 30489246 )
2018

Variations for Degenerative Disc Disease

Expression for Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for Degenerative Disc Disease

Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 ACAN ASPN BMP2 COL9A3 GDF5
2 10.56 ACAN ASPN COL9A3

GO Terms for Degenerative Disc Disease

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 BMP2 HIF1A MIR132 SOX9 VDR
2 negative regulation of gene expression GO:0010629 9.73 BMP2 HIF1A MIR132 SOX9
3 skeletal system development GO:0001501 9.62 ACAN BMP2 SOX9 VDR
4 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.57 BMP2 HIF1A
5 vasculature development GO:0001944 9.56 CALCA HIF1A
6 positive regulation of chondrocyte differentiation GO:0032332 9.55 GDF5 SOX9
7 cartilage condensation GO:0001502 9.54 ACAN SOX9
8 negative regulation of chondrocyte differentiation GO:0032331 9.52 GDF5 SOX9
9 chondrocyte development GO:0002063 9.51 ACAN SOX9
10 endocardial cushion morphogenesis GO:0003203 9.49 BMP2 SOX9
11 positive regulation of cartilage development GO:0061036 9.48 BMP2 SOX9
12 negative regulation of bone mineralization GO:0030502 9.46 HIF1A SOX9
13 epithelial to mesenchymal transition GO:0001837 9.43 BMP2 HIF1A SOX9
14 chondrocyte differentiation GO:0002062 9.37 BMP2 SOX9
15 cartilage development GO:0051216 9.26 BMP2 GDF5 HIF1A SOX9
16 negative regulation of ossification GO:0030279 9.16 HIF1A SOX9
17 negative regulation of mesenchymal cell apoptotic process GO:2001054 8.8 GDF5 HIF1A SOX9

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.62 ACAN ASPN

Sources for Degenerative Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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