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MCID: DGN001
MIFTS: 48

Degenerative Disc Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Degenerative Disc Disease

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MalaCards integrated aliases for Degenerative Disc Disease:

Name: Degenerative Disc Disease 12 54 15 37
Cervical Disc Degenerative Disorder 17 71
Intervertebral Disc Degeneration 12 71
Degeneration of Lumbar Intervertebral Disc 71
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 71
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:90
NCIt 49 C27156
UMLS 71 C0158252 C0158266 C0263874 more
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Summaries for Degenerative Disc Disease

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Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as cervical disc degenerative disorder, is related to intervertebral disc disease and back pain, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is LINC01562 (Long Intergenic Non-Protein Coding RNA 1562), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage.

Wikipedia : 74 Degenerative disc disease (DDD) is a medical condition in which there are anatomic changes and a loss of... more...

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Related Diseases for Degenerative Disc Disease

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Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 intervertebral disc disease 33.2 VDR COL9A3 ASPN
2 back pain 31.8 COL9A3 ASPN
3 spinal stenosis 31.1 COL9A3 CALCA ACAN
4 spondylolisthesis 31.0 GDF5 COL9A3 BMP2 ACAN
5 ankylosis 30.5 HIF1A GDF5 BMP2
6 discitis 30.5 CALCA ACAN
7 osteoarthritis 30.5 SOX9 GDF5 BMP2 ASPN ACAN
8 osteochondrosis 30.5 VDR SOX9 COL9A3 ACAN
9 paine syndrome 30.4 TRPV1 COMT CALCA
10 bone resorption disease 30.2 VDR CALCA BMP2
11 exostosis 30.2 GDF5 CALCA BMP2 ACAN
12 bone disease 30.0 VDR GDF5 CALCA BMP2 ACAN
13 spondyloepiphyseal dysplasia with congenital joint dislocations 11.5
14 loeys-dietz syndrome 3 11.5
15 radiculopathy 10.6
16 acute tympanitis 10.5 GDF5 ASPN
17 leprosy 2 10.5 NPY CALCA
18 aging 10.5
19 hypercalcemia, infantile, 1 10.4 VDR CALCA
20 perianal hematoma 10.4 NPY CALCA
21 hypochondrogenesis 10.4 ASPN ACAN
22 causalgia 10.4 TRPV1 CALCA
23 spondylosis 10.4
24 vasomotor rhinitis 10.4 TRPV1 NPY CALCA
25 detrusor sphincter dyssynergia 10.4 TRPV1 CALCA
26 autonomic nervous system disease 10.4 TRPV1 NPY CALCA
27 somatoform disorder 10.4 TRPV1 COMT CALCA
28 synovial chondromatosis 10.4 SOX9 BMP2
29 cartilage disease 10.3 SOX9 BMP2 ACAN
30 hypervitaminosis d 10.3 VDR CALCA
31 glucocorticoid-induced osteoporosis 10.3 VDR CALCA BMP2
32 fibromyalgia 10.3 NPY COMT CALCA
33 ischemic bone disease 10.3 CALCA BMP2 ACAN
34 carcinoid syndrome 10.3 NPY CALCA
35 multiple epiphyseal dysplasia 10.3 SOX9 COL9A3 ACAN
36 spondylosis, cervical 10.3
37 scoliosis 10.3
38 scoliosis, isolated 1 10.3
39 idiopathic scoliosis 10.3
40 rapidly involuting congenital hemangioma 10.3
41 retinitis pigmentosa 11 10.3
42 diabetes mellitus 10.3
43 congenital extrahepatic portosystemic shunt 10.3
44 brachydactyly, type a1, b 10.3 GDF5 BMP2
45 chromosome 2q35 duplication syndrome 10.3 SOX9 GDF5 BMP2
46 bone remodeling disease 10.3 VDR CALCA BMP2
47 myofascial pain syndrome 10.3 TRPV1 CALCA
48 epicondylitis 10.2 CALCA ACAN
49 dysphagia 10.2
50 brittle bone disorder 10.2 SOX9 CALCA BMP2 ACAN

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease
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Symptoms & Phenotypes for Degenerative Disc Disease

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UMLS symptoms related to Degenerative Disc Disease:


sciatica
Sources

Drugs & Therapeutics for Degenerative Disc Disease

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Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Eplerenone Approved Phase 4 107724-20-9 150310 443872
4 Dopamine Agents Phase 4
5 Antidepressive Agents Phase 4
6 Duloxetine Hydrochloride Phase 4
7 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
8 Mineralocorticoids Phase 4
9 Antihypertensive Agents Phase 4
10 Mineralocorticoid Receptor Antagonists Phase 4
11 Diuretics, Potassium Sparing Phase 4
12 diuretics Phase 4
13
tannic acid Approved Phase 3 1401-55-4
14
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
15
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
16
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
17
Racepinephrine Approved Phase 3 329-65-7 838
18
Infliximab Approved Phase 3 170277-31-3
19
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
20 Sodium Channel Blockers Phase 2, Phase 3
21 Antirheumatic Agents Phase 3
22 Respiratory System Agents Phase 3
23 Adrenergic beta-Agonists Phase 3
24 Adrenergic alpha-Agonists Phase 3
25 Epinephryl borate Phase 3
26 Vasoconstrictor Agents Phase 3
27 Anti-Asthmatic Agents Phase 3
28 Adrenergic Agonists Phase 3
29 Sympathomimetics Phase 3
30 Mydriatics Phase 3
31 Bronchodilator Agents Phase 3
32 Dermatologic Agents Phase 3
33 Adjuvants, Immunologic Phase 3
34 Viscosupplements Phase 3
35 Immunologic Factors Phase 3
36 Hemostatics Phase 3
37 Coagulants Phase 3
38 Fibrin Tissue Adhesive Phase 3
39
Mepivacaine Approved, Vet_approved Phase 1, Phase 2 96-88-8 4062
40
Pamidronate Approved Phase 1, Phase 2 40391-99-9 4674
41 Abaloparatide Approved, Investigational Phase 2 247062-33-5
42
Tranexamic Acid Approved Phase 2 1197-18-8 5526
43
Propranolol Approved, Investigational Phase 2 525-66-6 4946
44
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
45 Diphosphonates Phase 1, Phase 2
46 Pharmaceutical Solutions Phase 2
47 Neurotransmitter Agents Phase 2
48 Antifibrinolytic Agents Phase 2
49 Anti-Arrhythmia Agents Phase 2
50 Adrenergic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 356)
# Name Status NCT ID Phase Drugs
1 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
2 A Prospective Study of the InterFuse T(tm) Unknown status NCT02678130 Phase 4
3 Study of an Expandable Interbody Device for the Lumbar Spine Completed NCT02075554 Phase 4
4 A Prospective, Multi-Center, Post-Market Surveillance Study to Assess the Clinical Efficacy and Fusion Rates of the Zimmer TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
5 Comparison of Internal Disc Decompression (IDD) vs. a Standardized Non-surgical Treatment Program for Chronic Low Back Pain Secondary to Mild to Moderate Degenerative Disc Disease (DDD) Completed NCT00165893 Phase 4
6 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
7 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
8 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
9 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOsâ„¢ and Bonionâ„¢ Completed NCT01615328 Phase 4
10 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
11 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
12 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Active, not recruiting NCT03077204 Phase 4
13 Clinical Investigation of NanoFUSE® Bioactive Matrix and Autogenous Bone in Posterolateral Spinal Fusion (Nonloadbearing) Not yet recruiting NCT03751943 Phase 4
14 Epidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized Trial Suspended NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
15 A Multi-Centre, Prospective, Randomized, Post Marketing Surveillance Study Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
16 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
17 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
18 A Prospective, Multi-center, Randomized, Active-Controlled Study of the Wallis System for the Treatment of Mild to Moderate Degenerative Disc Disease of the Lumbar Spine Unknown status NCT00484458 Phase 3
19 A Prospective, Multicenter, Randomized Study Comparing the Use of HEALOS® to Autograft in a Transforaminal Lumbar Interbody Fusion (TLIF) Approach Completed NCT00316121 Phase 3
20 A Multi-center Study to Evaluate the Safety and Efficacy of DePuy AcroMed Titanium Surgical Mesh and MOSS-Miami Spinal Fixation System Pedicle Screws for Intradiscal Fusion in the Lumbar Spine Completed NCT00215319 Phase 3
21 A Pivotal, Multi-Center, Clinical Trial Evaluating The Safety And Effectiveness of The Lumbar TDR Device In Patients With Single-Level Lumbar Degenerative Disc Disease Completed NCT00927238 Phase 3
22 A Prospective, Randomized Clinical Investigation of rhBMP-2 and Compression Resistant Matrix With the CD HORIZON® Spinal System for Posterolateral Lumbar Fusion in Patients With Symptomatic Degenerative Disc Disease Completed NCT00707265 Phase 3
23 A Prospective, Multicenter, Controlled Clinical Trial of an Artificial Cervical Disc LP at a Single Level for Symptomatic Cervical Disc Disease Completed NCT00667459 Phase 3
24 Clinical Investigation of the SB Charite III Intervertebral Disc Spacer. Completed NCT00215306 Phase 3
25 A Randomized Multi-Center Study to Evaluate the Safety and Efficacy of the Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
26 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Completed NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
27 "A Prospective, Randomized Controlled Clinical Investigation of MAVERICKâ„¢ Total Disc Replacement in Patients With Degenerative Disc Disease" Completed NCT00635843 Phase 3
28 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
29 A Phase 2/3 Prospective, Multicentre Randomized, Double-blind Trial, Comparing Intra-discal Allogeneic Adult BM-MSC Therapy and Sham-treated Controls in Subjects With Chronic LBP Due to Lumbar DDD Unresponsive to Conventional Therapy Recruiting NCT03737461 Phase 2, Phase 3 Allogenic BM-MSCs Injection
30 Efficacy of Peri-Incisional Multimodal Drug Injection in Reducing Post-Operative Pain Following Lumbar Spine Surgery Recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
31 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
32 Evaluation of Regenerative Medicine Treatment Outcomes With Amniotic Fluid for Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
33 The Effect of Infliximab in Patients With Chronic Low Back Pain and Modic Changes. A Randomized, Double Blind, Placebo-controlled, Multicenter Trial Recruiting NCT03704363 Phase 3 Biosimilar Infliximab
34 A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
35 A Post-market, Prospective, Multi-center, Nonrandomized Study to Assess Posterolateral Lumbar Fusions Using FIBERGRAFT BG Matrix Enrolling by invitation NCT03884283 Phase 3
36 A Multicenter, Randomized, Blinded, Saline-Controlled Trial of Resorbable Biologic Disc Augmentation for Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
37 A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion Unknown status NCT00798902 Phase 1, Phase 2
38 A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion Unknown status NCT00798239 Phase 1, Phase 2
39 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
40 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01124006 Phase 2 Intradiscal rhGDF-5
41 Phase I/II, Multicenter, Open-label, Single Administration, Dose Finding, Clinical Trial to Evaluate the Safety and Tolerability of Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT00813813 Phase 1, Phase 2 Intradiscal rhGDF-5
42 A Double-blind, Randomized, Parallel, Placebo Controlled, Phase I/II Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH14618 Following Single Intradiscal Injection in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
43 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01182337 Phase 1, Phase 2 Intradiscal rhGDF-5;Vehicle control
44 A Phase I/IIa, Multicenter, Open-label, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01158924 Phase 1, Phase 2 Intradiscal rhGDF-5
45 A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 2b Trial to Evaluate the Efficacy and Safety of YH14618 in Patients With Lumbar Degenerative Disc Disease Completed NCT02320019 Phase 2 Placebo;YH14618
46 Treatment of Lumbar Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV*) *MSV: Bone Marrow Mesenchymal Stromal Cells Expanded Using the Valladolid IBGM Procedure Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
47 Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation Completed NCT01106417 Phase 2
48 Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation Completed NCT01097486 Phase 2
49 Clinical Trial Phase I / II Prospective, Open, Non-randomized for Treatment of Lumbar Intervertebral Degenerative Disc Disease With Posterolateral Instrumented and Autologous Mesenchymal Stem Cells. Completed NCT01513694 Phase 1, Phase 2
50 A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With Instrumentation Completed NCT00996073 Phase 2

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Degenerative Disc Disease:
Bone marrow-derived mesenchymal stem cells for lumbar intervertebral degenerative disc disease
MPCs, mesenchymal precursor cells for degenerative disc disease
NuCel, amniotic tissue-derived cells for treatment of degenerative disc disease
NuQu, juvenile cartilage cells for disc repair
OsteocellPlus, human mesenchymal stem cells for treatment of degenerative disc disease
RNL-JointStem, adipose-derived mesenchymal stem cells for degenerative arthritis
Trinity Evolution, mesenchymal stem cells with osteoprogenitors for musculoskeletal defects
Embryonic/Adult Cultured Cells Related to Degenerative Disc Disease:
Bone marrow-derived mesenchymal stem cells (family)
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 20528753
Juvenile cartilage (NuQu) PMIDs: 23140128
Juvenile cartilage PMIDs: 23140128
Cellular bone matrix containing mesenchymal stem cells (Osteocel Plus) PMIDs: 23182179
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Demineralized bone with osteoprogenitor and adult stem cells (Trinity Evolution) PMIDs: 20508015 21056860
Sources

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Degenerative Disc Disease:

19
Intervertebral Disc

MalaCards organs/tissues related to Degenerative Disc Disease:

40
Bone, Bone Marrow, Testes, Spinal Cord, Endothelial, Kidney, Thyroid
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Degenerative Disc Disease

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Articles related to Degenerative Disc Disease:

(show top 50) (show all 3595)
# Title Authors PMID Year
1
The genetics of intervertebral disc degeneration. Associated genes. 54 61
18485784 2008
2
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 54 61
17669279 2007
3
Changes of the end plate cartilage are associated with intervertebral disc degeneration: A quantitative magnetic resonance imaging study in rhesus monkeys and humans. 61
32542179 2020
4
Evaluation of DIAMâ„¢ Spinal Stabilization System for lower lumbar disc degenerative disease: A randomized, prospective, single-site study. 61
32256000 2020
5
Amyloid protein aggregation in diabetes mellitus accelerate intervertebral disc degeneration. 61
32305815 2020
6
Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis. 61
32240779 2020
7
Thermosensitive hydrogels loaded with human-induced pluripotent stem cells overexpressing growth differentiation factor-5 ameliorate intervertebral disc degeneration in rats. 61
31930605 2020
8
Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. 61
31975410 2020
9
Identifying compositional and structural changes in the nucleus pulposus from patients with lumbar disc herniation using Raman spectroscopy. 61
32537009 2020
10
Etiology-Based Classification of Adjacent Segment Disease Following Lumbar Spine Fusion. 61
32523480 2020
11
Biomechanical Effect of L4 -L5 Intervertebral Disc Degeneration on the Lower Lumbar Spine: A Finite Element Study. 61
32476282 2020
12
Sirt1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun. 61
32572902 2020
13
Understanding embryonic development for cell-based therapies of intervertebral disc degeneration: Towards an effort to treat disc degeneration subphenotypes. 61
32564440 2020
14
A Meta-analysis Assessing the Association Between COL11A1 and GDF5 Genetic Variants and Intervertebral Disc Degeneration Susceptibility. 61
31923126 2020
15
Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration. 61
32487144 2020
16
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C. 61
32564456 2020
17
Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway. 61
32265028 2020
18
Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values. 61
32500176 2020
19
Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway. 61
32526705 2020
20
Comparing Cortical Bone Trajectories for Pedicle Screw Insertion using Robotic Guidance and Three-Dimensional Computed Tomography Navigation. 61
32522651 2020
21
Relationship Between Preoperative Opioid Use and Postoperative Pain in Patients Undergoing Minimally Invasive Stand-Alone Lateral Lumbar Interbody Fusion. 61
32526027 2020
22
The Majority of Total Hip Arthroplasty Patients With a Stiff Spine Do Not Have an Instrumented Fusion. 61
32089366 2020
23
Histomorphology and immunohistochemical patterns in degenerative disc disease and clinical-radiological correlations: a prospective study. 61
32300951 2020
24
Mobilisation efficacy in young patients with different stages of degenerative disc disease. 61
32568172 2020
25
Clinical-neurophysiological-neuroradiological discordance in lumbar degenerative disc disease: should the neurosurgeon have the last word? 61
29905431 2020
26
Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients exposed to microvascular endothelial cells conditioned medium. 61
32541845 2020
27
Transforaminal endoscopic decompression and uninstrumented allograft lumbar interbody fusion: A feasibility study in patients with end-stage vacuum degenerative disc disease. 61
32562950 2020
28
Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics. 61
31840817 2020
29
Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats. 61
32546053 2020
30
Microanatomy of the lumbar vertebral bony endplate of rats using scanning electron microscopy. 61
32359955 2020
31
Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. 61
31900828 2020
32
High-glucose environment accelerates annulus fibrosus cell apoptosis by regulating endoplasmic reticulum stress. 61
32515472 2020
33
Comprehensive multi-factors reveal the pathogenesis of degenerative intervertebral disc. 61
32538749 2020
34
Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway. 61
32526681 2020
35
Reciprocal relationship between multifidus and psoas at L4-L5 level in women with low back pain. 61
32576034 2020
36
circ_001653 Silencing Promotes the Proliferation and ECM Synthesis of NPCs in IDD by Downregulating miR-486-3p-Mediated CEMIP. 61
32203911 2020
37
MiR-96 promotes apoptosis of nucleus pulpous cells by targeting FRS2. 61
32578051 2020
38
Full Percutaneous Treatment of Degenerative Disc Disease with Intradiscal Lumbar Interbody Fusion and Posterior Stabilization: Preliminary Results. 61
32342158 2020
39
Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway. 61
32151764 2020
40
Trends in Anterior Lumbar Interbody Fusion in the United States: A MarketScan Study From 2007 to 2014. 61
31609798 2020
41
[The Facet Wedge: a minimally invasive technique for posterior segmental intra-articular fusion]. 61
32179944 2020
42
[Minimally invasive stand-alone fusion of the lumbosacral junction]. 61
32468147 2020
43
[Minimally invasive transforaminal lumbar interbody fusion]. 61
32447419 2020
44
Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration. 61
32567210 2020
45
Influences of circulatory factors on intervertebral disc aging phenotype. 61
32527988 2020
46
Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model. 61
31875985 2020
47
Evaluation of facet joints and segmental motion in patients with different grades of L5/S1 intervertebral disc degeneration: a kinematic MRI study. 61
32504265 2020
48
Quantitative analysis of intervertebral disc degeneration using Q-space imaging in a rat model. 61
32458477 2020
49
NF-κB inhibitor, NEMO-binding domain peptide attenuates intervertebral disc degeneration. 61
32413485 2020
50
Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance imaging. 61
32468097 2020
Sources

Variations for Degenerative Disc Disease

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Expression for Degenerative Disc Disease

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Search GEO for disease gene expression data for Degenerative Disc Disease.
Sources

Pathways for Degenerative Disc Disease

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Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 65
Show member pathways
 12.21 GDF5 COL9A3 BMP2 ASPN ACAN
2
Mesenchymal Stem Cells and Lineage-specific Markers 64
10.9 SOX9 GDF5 BMP2 ACAN
3
ECM proteoglycans 65
10.89 COL9A3 ASPN ACAN
Sources

GO Terms for Degenerative Disc Disease

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Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.95 VDR SOX9 RELA CALCA BMP2
2 positive regulation of gene expression GO:0010628 9.89 VDR SOX9 MIR132 HIF1A BMP2
3 negative regulation of gene expression GO:0010629 9.77 VDR SOX9 MIR132 HIF1A BMP2
4 skeletal system development GO:0001501 9.76 VDR SOX9 BMP2 ACAN
5 cellular response to interleukin-1 GO:0071347 9.69 SOX9 RELA HIF1A
6 epithelial to mesenchymal transition GO:0001837 9.61 SOX9 HIF1A BMP2
7 chondrocyte development GO:0002063 9.58 SOX9 ACAN
8 endocardial cushion morphogenesis GO:0003203 9.58 SOX9 BMP2
9 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.58 RELA HIF1A BMP2
10 positive regulation of cartilage development GO:0061036 9.57 SOX9 BMP2
11 negative regulation of bone mineralization GO:0030502 9.56 SOX9 HIF1A
12 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.54 TRPV1 CALCA
13 negative regulation of pri-miRNA transcription by RNA polymerase II GO:1902894 9.52 SOX9 RELA
14 negative regulation of ossification GO:0030279 9.5 SOX9 HIF1A CALCA
15 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.48 RELA BMP2
16 response to pain GO:0048265 9.43 TRPV1 COMT CALCA
17 positive regulation of chondrocyte differentiation GO:0032332 9.33 SOX9 RELA GDF5
18 cartilage development GO:0051216 9.26 SOX9 HIF1A GDF5 BMP2
19 negative regulation of mesenchymal cell apoptotic process GO:2001054 8.8 SOX9 HIF1A GDF5

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.62 ASPN ACAN
Sources

Sources for Degenerative Disc Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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