MCID: DGN002
MIFTS: 31

Degenerative Myopia

Categories: Eye diseases

Aliases & Classifications for Degenerative Myopia

MalaCards integrated aliases for Degenerative Myopia:

Name: Degenerative Myopia 12 15
Myopia, Degenerative 44 73
Degenerative Progressive High Myopia 12
Progressive High Myopia 12
Progressive High Myopia 12
Pathological Myopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11829
ICD10 33 H44.2
ICD9CM 35 360.21
MeSH 44 D047728
SNOMED-CT 68 32022003
UMLS 73 C0154778

Summaries for Degenerative Myopia

MalaCards based summary : Degenerative Myopia, also known as myopia, degenerative, is related to myopia and stickler syndrome, type i, nonsyndromic ocular. An important gene associated with Degenerative Myopia is ZNF644 (Zinc Finger Protein 644), and among its related pathways/superpathways are ECM proteoglycans and Cell adhesion_Plasmin signaling. The drugs Ranibizumab and Povidone have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is behavior/neurological.

Related Diseases for Degenerative Myopia

Graphical network of the top 20 diseases related to Degenerative Myopia:



Diseases related to Degenerative Myopia

Symptoms & Phenotypes for Degenerative Myopia

MGI Mouse Phenotypes related to Degenerative Myopia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 CHRNG GCNT2 GJD2 LAMA1 LUM VEGFA

Drugs & Therapeutics for Degenerative Myopia

Drugs for Degenerative Myopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1 347396-82-1 459903
2
Povidone Approved Phase 4 9003-39-8
3
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
4
Iodine Approved, Investigational Phase 4 7553-56-2 807
5
Ofloxacin Approved Phase 4 82419-36-1 4583
6
Povidone-iodine Approved Phase 4 25655-41-8
7
Lactitol Investigational Phase 4 585-86-4 3871
8 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
9 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
11 cadexomer iodine Phase 4
12 Ophthalmic Solutions Phase 4
13
Verteporfin Approved, Investigational Phase 3 129497-78-5
14 Dermatologic Agents Phase 3
15 Photosensitizing Agents Phase 3
16 Pharmaceutical Solutions Phase 3
17
Bevacizumab Approved, Investigational Phase 1 216974-75-3

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization Recruiting NCT03042871 Phase 4 0.5mg intravitreal ranibizumab
2 A Randomized, Double-blind, Multicenter, Sham-controlled, Safety and Efficacy Study of Conbercept in Patients With mCNV Unknown status NCT01809223 Phase 3 conbercept, Fixed;conbercept, PRN
3 Efficacy and Safety of Ranibizumab in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia Completed NCT01217944 Phase 3 Ranibizumab;Verteporfin PDT;Sham Ranibizumab;Sham verteporfin PDT
4 A Study of the Criteria Establishing the Need for Re-treatment With Ranibizumab Upon Relapse in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia. Completed NCT02034006 Phase 3 Ranibizumab
5 Effectiveness of Orthokeratology in Decreasing Myopic Progression in a Young Adult Population Enrolled in a Professional Optometric Curriculum Unknown status NCT02623543 Phase 2
6 Ranibizumab for the Treatment of Choroidal Neovascularisation (CNV) Secondary to Pathological Myopia (PM): an Individualized Regimen Completed NCT01037348 Phase 2 ranibizumab 0.5mg
7 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
8 Bevicizumab (Avastin) Infusion for Choroidal Neovascularization (CNV) Not Associated With Age-Related Macular Degeneration (AMD) Completed NCT00407719 Phase 1 Bevacizumab
9 The Efficacy and Safety of Periocular Acupoint Stimulation on Myopia Progression in Children Completed NCT02064660 Phase 1
10 Genomewide Screening of Pathological Myopia Unknown status NCT00155753
11 The Role of SNP of ECM and MMP on the Development of Pathological High Myopia Unknown status NCT00172952
12 The Relationship Between Structure and Visual Function in Myopia Foveoschisis Unknown status NCT02915133
13 Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular Diseases Recruiting NCT03128463 Intravitreal injection of conbercept
14 Effectiveness of Orthokeratology in Myopia Control Recruiting NCT03465748 Not Applicable
15 Shanghai Child and Adolescent Large-scale Eye Study -High Myopia Registration Enrolling by invitation NCT03666052

Search NIH Clinical Center for Degenerative Myopia

Cochrane evidence based reviews: myopia, degenerative

Genetic Tests for Degenerative Myopia

Anatomical Context for Degenerative Myopia

MalaCards organs/tissues related to Degenerative Myopia:

41
Eye

Publications for Degenerative Myopia

Articles related to Degenerative Myopia:

(show all 21)
# Title Authors Year
1
Degenerative myopia: myopic macular schisis and the posterior pole buckle. ( 23190923 )
2013
2
Pathology of macular foveoschisis associated with degenerative myopia. ( 20814547 )
2010
3
Aqueous humor level of sCD44 in patients with degenerative myopia and primary open-angle glaucoma. ( 19895708 )
2009
4
Effect of peripapillary chorioretinal atrophy on GDx parametersin patients with degenerative myopia. ( 12427231 )
2002
5
Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and degenerative myopia. ( 11162982 )
2001
6
Choroidal and retinal blood flow changes in degenerative myopia. ( 8743218 )
1996
7
Photocoagulation scar expansion after laser therapy for choroidal neovascularization in degenerative myopia. ( 1708513 )
1990
8
Choroidal neovascularization in degenerative myopia: role of laser photocoagulation. ( 2448722 )
1987
9
Familial sinus node disease and degenerative myopia--a new hereditary syndrome? ( 3943873 )
1986
10
Natural history of choroidal neovascularization in degenerative myopia. ( 6084222 )
1984
11
The etiopathogenesis of degenerative myopia. ( 6229208 )
1983
12
Aetiopathogenesis of degenerative myopia. A hypothesis. ( 6216444 )
1982
13
Degenerative myopia. ( 4697188 )
1973
14
A simplified technique for surgical treatment of degenerative myopia. ( 5054236 )
1972
15
Scleral reinforcement in degenerative myopia. ( 5291554 )
1971
16
THE CONCEPT OF DEGENERATIVE MYOPIA. ( 14262010 )
1965
17
The glaucomatous disc in degenerative myopia. ( 5227179 )
1965
18
SURGICAL TREATMENT OF DEGENERATIVE MYOPIA. SCLERAL REINFORCEMENT. ( 14167191 )
1964
19
Surgical treatment of degenerative myopia. ( 5889605 )
1963
20
Retinal changes in degenerative myopia. ( 13900972 )
1962
21
Surgical treatment of degenerative myopia; the combined lamellar scleral resection with scleral reinforcement using donor eye. ( 13635801 )
1958

Variations for Degenerative Myopia

Expression for Degenerative Myopia

Search GEO for disease gene expression data for Degenerative Myopia.

Pathways for Degenerative Myopia

Pathways related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.91 LAMA1 LUM
2 10.65 LAMA1 VEGFA
3 10.04 LAMA1 VEGFA

GO Terms for Degenerative Myopia

Cellular components related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.8 LAMA1 LUM VEGFA

Biological processes related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.8 CRYAA GJD2 LUM

Sources for Degenerative Myopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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