DSPS
MCID: DLY008
MIFTS: 45

Delayed Sleep Phase Disorder (DSPS)

Categories: Mental diseases

Aliases & Classifications for Delayed Sleep Phase Disorder

MalaCards integrated aliases for Delayed Sleep Phase Disorder:

Name: Delayed Sleep Phase Disorder 57
Delayed Sleep Phase Syndrome 57 12 76 75 37 55 15 73
Delayed Sleep Phase Syndrome, Susceptibility to 57 13
Dspd 57 12
Sleep Phase Syndrome, Delayed, Susceptibility to 40
Delayed Sleep Phase Disorder, Susceptibility to 57
Sleep Phase, Delayed, Disorder 40
Dsps 75

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
variable manifestations of disrupted sleep


Classifications:



External Ids:

OMIM 57 614163
Disease Ontology 12 DOID:0111141
MeSH 44 D020178
KEGG 37 H00689
SNOMED-CT via HPO 69 193462001
UMLS 73 C0393770

Summaries for Delayed Sleep Phase Disorder

OMIM : 57 Delayed sleep phase syndrome is a circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPD have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. Although psychosocial and environmental factors sometimes induce this kind of disorder, most patients with DSPD appear to have an abnormal circadian pacemaker and/or an abnormal entrainment system (summary by Hohjoh et al., 2003). (614163)

MalaCards based summary : Delayed Sleep Phase Disorder, also known as delayed sleep phase syndrome, is related to epidermolysis bullosa, lethal acantholytic and woolly hair syndrome. An important gene associated with Delayed Sleep Phase Disorder is DSPS (Delayed Sleep Phase Syndrome, Susceptibility To), and among its related pathways/superpathways are Tryptophan metabolism and Metabolic pathways. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are insomnia and nervous system

Disease Ontology : 12 A sleep disorder characterized by an extreme evening preference, sleep-onset insomnia, and difficulty in awakening at the desired time.

UniProtKB/Swiss-Prot : 75 Delayed sleep phase syndrome: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities.

Wikipedia : 76 Delayed sleep phase disorder (DSPD), more often known as delayed sleep phase syndrome and also as... more...

Related Diseases for Delayed Sleep Phase Disorder

Diseases related to Delayed Sleep Phase Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 epidermolysis bullosa, lethal acantholytic 11.4
2 woolly hair syndrome 11.3
3 cardiomyopathy, dilated, with woolly hair and keratoderma 11.2
4 porokeratosis 3, multiple types 11.0
5 arrhythmogenic right ventricular dysplasia, familial, 8 11.0
6 porokeratosis 7, multiple types 11.0
7 porokeratosis 9, multiple types 11.0
8 personality disorder 10.1
9 primary amebic meningoencephalitis 10.1
10 epidermolysis bullosa 10.1
11 prostate cancer 10.1
12 lung cancer 10.1
13 neuroblastoma 10.1
14 hepatosplenic t-cell lymphoma 10.1
15 depression 10.0
16 schizophrenia 9.9
17 scapuloperoneal myopathy, x-linked dominant 9.9
18 skin fragility-woolly hair syndrome 9.9
19 alopecia 9.9
20 arrhythmogenic right ventricular cardiomyopathy 9.9
21 uveitis 9.9
22 root resorption 9.9
23 palmoplantar keratosis 9.9
24 porokeratosis 9.9
25 amyloidosis 9.9
26 anterior uveitis 9.9
27 autoimmune progesterone dermatitis 9.9
28 skin fragility-woolly hair-palmoplantar keratoderma syndrome 9.9
29 erythrokeratodermia-cardiomyopathy syndrome 9.9
30 lichen amyloidosis 9.9
31 multiple sclerosis 9.9
32 brain injury 9.9
33 traumatic brain injury 9.9
34 mood disorder 9.8 CLOCK PER3
35 obsessive-compulsive disorder 9.8
36 bipolar disorder 9.8
37 headache 9.8
38 sleep disorder 9.8 CRY1 PER2 PER3
39 advanced sleep phase syndrome 9.2 AANAT CABP4 CLOCK PER2 PER3

Graphical network of the top 20 diseases related to Delayed Sleep Phase Disorder:



Diseases related to Delayed Sleep Phase Disorder

Symptoms & Phenotypes for Delayed Sleep Phase Disorder

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
delayed onset of sleep
sleep phase delay
fragmented sleep

Metabolic Features:
abnormal circadian rhythm
abnormal core temperature oscillation patterns


Clinical features from OMIM:

614163

Human phenotypes related to Delayed Sleep Phase Disorder:

32
# Description HPO Frequency HPO Source Accession
1 insomnia 32 HP:0100785

MGI Mouse Phenotypes related to Delayed Sleep Phase Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 AANAT CABP4 CLOCK CRY1 PER2 PER3

Drugs & Therapeutics for Delayed Sleep Phase Disorder

Drugs for Delayed Sleep Phase Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Phase 1,Not Applicable 73-31-4 896
2 Antioxidants Phase 1,Not Applicable
3 Protective Agents Phase 1,Not Applicable
4 Central Nervous System Depressants Phase 1,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD) Completed NCT01406691 Phase 4
2 Synchronization and Desynchronization Between Circadian Rhythms in Patients With Delayed Sleep Phase Syndrome (DSPS) Unknown status NCT00282061 Phase 1 Melatonin
3 Circadian Phase Assessments at Home Completed NCT01487252 Not Applicable
4 Melatonin Treatment for Induced Transient Insomnia Completed NCT00950885 Not Applicable
5 Circadian Rhythm Dysregulation in Offspring of Parents With Bipolar Disorder Recruiting NCT03656302
6 Light Sensitization Study Active, not recruiting NCT01327040 Not Applicable

Search NIH Clinical Center for Delayed Sleep Phase Disorder

Genetic Tests for Delayed Sleep Phase Disorder

Anatomical Context for Delayed Sleep Phase Disorder

MalaCards organs/tissues related to Delayed Sleep Phase Disorder:

41
Brain, Testes, Eye, Lung, Skin, Prostate, T Cells

Publications for Delayed Sleep Phase Disorder

Articles related to Delayed Sleep Phase Disorder:

(show top 50) (show all 117)
# Title Authors Year
1
Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers. ( 29534856 )
2018
2
The pupillary light reflex distinguishes between circadian and non-circadian delayed sleep phase disorder (DSPD) phenotypes in young adults. ( 30261080 )
2018
3
Effect of aripiprazole monotherapy in a patient presenting with delayed sleep phase syndrome associated with depressive symptoms. ( 29508475 )
2018
4
Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation. ( 29849459 )
2018
5
Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder. ( 28364473 )
2017
6
Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder. ( 28388406 )
2017
7
Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder: An open-label trial. ( 27322730 )
2016
8
Prevalence of Circadian Misalignment and Its Association with Depressive Symptoms in Delayed Sleep Phase Disorder. ( 27692050 )
2016
9
Light Therapy With Scheduled Rise Times in Young Adults With Delayed Sleep Phase Disorder: Therapeutic Outcomes and Possible Predictors. ( 27712107 )
2016
10
Home dim light melatonin onsets with measures of compliance in delayed sleep phase disorder. ( 26847016 )
2016
11
The etiology of delayed sleep phase disorder. ( 26434674 )
2016
12
Delayed sleep phase disorder: clinical perspective with a focus on light therapy. ( 27110143 )
2016
13
Cognitive Behavioral Therapy as an Adjunct Treatment to Light Therapy for Delayed Sleep Phase Disorder in Young Adults: A Randomized Controlled Feasibility Study. ( 26244417 )
2016
14
Delayed sleep phase disorder in a Swedish cohort of adolescents and young adults: Prevalence and associated factors. ( 27537980 )
2016
15
Delayed sleep phase disorder risk is associated with absenteeism and impaired functioning. ( 29073375 )
2015
16
Out of synch with society: an update on delayed sleep phase disorder. ( 25160887 )
2014
17
Aripiprazole is effective for treatment of delayed sleep phase syndrome. ( 24992089 )
2014
18
The personality profile of young adults with delayed sleep phase disorder. ( 24283705 )
2014
19
A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep. ( 24144243 )
2014
20
Difficult morning awakening from rapid eye movement sleep and impaired cognitive function in delayed sleep phase disorder patients. ( 25156750 )
2014
21
Objective measures of sleep and dim light melatonin onset in adolescents and young adults with delayed sleep phase disorder compared to healthy controls. ( 23363423 )
2013
22
The endogenous circadian temperature period length (tau) in delayed sleep phase disorder compared to good sleepers. ( 23899423 )
2013
23
Obsessive-compulsive symptoms and characteristics in individuals with delayed sleep phase disorder. ( 24080675 )
2013
24
Delayed sleep phase syndrome in adolescents: prevalence and correlates in a large population based study. ( 24330358 )
2013
25
A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective and objective sleepiness and cognitive function. ( 24132057 )
2013
26
Delayed sleep phase syndrome: a forerunner of psychiatric distress. ( 24304991 )
2013
27
Delayed sleep phase disorder in an Australian school-based sample of adolescents. ( 23997706 )
2013
28
Delayed sleep phase disorder in youth. ( 24060912 )
2013
29
Systematic evaluation of Axis-I DSM diagnoses in delayed sleep phase disorder and evening-type circadian preference. ( 22910327 )
2012
30
Evaluation of two circadian rhythm questionnaires for screening for the delayed sleep phase disorder. ( 22993522 )
2012
31
Delayed sleep phase syndrome is related to seasonal affective disorder. ( 21601293 )
2011
32
Relation between morningness-eveningness score and depressive symptoms among patients with delayed sleep phase syndrome. ( 21669551 )
2011
33
Delayed sleep phase syndrome and depression. ( 21704558 )
2011
34
Total sleep deprivation study in delayed sleep-phase syndrome. ( 23250347 )
2011
35
Light exposure among adolescents with delayed sleep phase disorder: a prospective cohort study. ( 22080736 )
2011
36
A randomized controlled trial of cognitive-behavior therapy plus bright light therapy for adolescent delayed sleep phase disorder. ( 22131604 )
2011
37
Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder. ( 20469812 )
2010
38
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. ( 20044310 )
2010
39
Outcome of combined melatonin and bright light treatments for delayed sleep phase disorder. ( 20560855 )
2010
40
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. ( 21120122 )
2010
41
Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome? ( 19756996 )
2009
42
Sleep timing and circadian phase in delayed sleep phase syndrome. ( 19625733 )
2009
43
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. ( 18725185 )
2009
44
Delayed sleep phase disorder and attention deficit and hyperactivity symptoms in a teenager. ( 21432583 )
2009
45
The prevalence of probable delayed-sleep-phase syndrome in students from junior high school to university in Tottori, Japan. ( 18719343 )
2008
46
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. ( 18078449 )
2008
47
Trauma, multiple sclerosis, delayed sleep phase disorder, subjective experiences, and duration of illness in GAD. ( 18496473 )
2008
48
Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice. ( 17445238 )
2007
49
Delayed sleep phase syndrome, ADHD, and bright light therapy. ( 17335340 )
2007
50
A prospective study of delayed sleep phase syndrome in patients with severe resistant obsessive-compulsive disorder. ( 18235868 )
2007

Variations for Delayed Sleep Phase Disorder

ClinVar genetic disease variations for Delayed Sleep Phase Disorder:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 AANAT NM_001166579.1(AANAT): c.520G> A (p.Ala174Thr) single nucleotide variant Uncertain significance rs28936679 GRCh37 Chromosome 17, 74465813: 74465813
2 AANAT NM_001166579.1(AANAT): c.520G> A (p.Ala174Thr) single nucleotide variant Uncertain significance rs28936679 GRCh38 Chromosome 17, 76469731: 76469731
3 CRY1 NM_004075.4(CRY1): c.1657+3A> C single nucleotide variant risk factor rs184039278 GRCh38 Chromosome 12, 106992962: 106992962
4 CRY1 NM_004075.4(CRY1): c.1657+3A> C single nucleotide variant risk factor rs184039278 GRCh37 Chromosome 12, 107386740: 107386740

Expression for Delayed Sleep Phase Disorder

Search GEO for disease gene expression data for Delayed Sleep Phase Disorder.

Pathways for Delayed Sleep Phase Disorder

Pathways related to Delayed Sleep Phase Disorder according to KEGG:

37
# Name Kegg Source Accession
1 Tryptophan metabolism hsa00380
2 Metabolic pathways hsa01100

GO Terms for Delayed Sleep Phase Disorder

Cellular components related to Delayed Sleep Phase Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 AANAT CABP4 CEP192 CLOCK CRY1 PER2

Biological processes related to Delayed Sleep Phase Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.71 CLOCK CRY1 PER2
2 response to insulin GO:0032868 9.52 AANAT CRY1
3 regulation of insulin secretion GO:0050796 9.51 CLOCK PER2
4 response to light stimulus GO:0009416 9.5 AANAT PER2 PER3
5 negative regulation of protein ubiquitination GO:0031397 9.49 CRY1 PER2
6 regulation of circadian rhythm GO:0042752 9.48 CRY1 PER2
7 gluconeogenesis GO:0006094 9.46 CRY1 PER2
8 circadian regulation of gene expression GO:0032922 9.46 CLOCK CRY1 PER2 PER3
9 negative regulation of circadian rhythm GO:0042754 9.43 CRY1 PER2
10 entrainment of circadian clock by photoperiod GO:0043153 9.43 CRY1 PER2 PER3
11 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.4 CLOCK CRY1
12 photoperiodism GO:0009648 9.37 AANAT CLOCK
13 rhythmic process GO:0048511 9.35 AANAT CLOCK CRY1 PER2 PER3
14 circadian rhythm GO:0007623 9.02 AANAT CLOCK CRY1 PER2 PER3

Molecular functions related to Delayed Sleep Phase Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.43 CRY1 PER2 PER3
2 kinase binding GO:0019900 9.37 CRY1 PER3
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.32 PER2 PER3
4 E-box binding GO:0070888 9.16 CLOCK CRY1
5 phosphatase binding GO:0019902 8.96 CEP192 CRY1
6 transcription corepressor binding GO:0001222 8.62 PER2 PER3

Sources for Delayed Sleep Phase Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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