Aliases & Classifications for Delayed Sleep Phase Disorder

MalaCards integrated aliases for Delayed Sleep Phase Disorder:

Name: Delayed Sleep Phase Disorder 57
Delayed Sleep Phase Syndrome 57 12 76 75 37 55 73
Delayed Sleep Phase Syndrome, Susceptibility to 57 13
Dspd 57 12
Sleep Phase Syndrome, Delayed, Susceptibility to 40
Delayed Sleep Phase Disorder, Susceptibility to 57
Sleep Phase, Delayed, Disorder 40
Dsps 75

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
variable manifestations of disrupted sleep


Classifications:



External Ids:

OMIM 57 614163
Disease Ontology 12 DOID:0111141
MeSH 44 D020178
KEGG 37 H00689
UMLS 73 C0393770

Summaries for Delayed Sleep Phase Disorder

OMIM : 57 Delayed sleep phase syndrome is a circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPD have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. Although psychosocial and environmental factors sometimes induce this kind of disorder, most patients with DSPD appear to have an abnormal circadian pacemaker and/or an abnormal entrainment system (summary by Hohjoh et al., 2003). (614163)

MalaCards based summary : Delayed Sleep Phase Disorder, also known as delayed sleep phase syndrome, is related to epidermolysis bullosa, lethal acantholytic and woolly hair syndrome. An important gene associated with Delayed Sleep Phase Disorder is DSPS (Delayed Sleep Phase Syndrome, Susceptibility To), and among its related pathways/superpathways are Tryptophan metabolism and Metabolic pathways. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye.

Disease Ontology : 12 A sleep disorder characterized by an extreme evening preference, sleep-onset insomnia, and difficulty in awakening at the desired time.

UniProtKB/Swiss-Prot : 75 Delayed sleep phase syndrome: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities.

Wikipedia : 76 Delayed sleep phase disorder (DSPD), more often known as delayed sleep phase syndrome and also as... more...

Related Diseases for Delayed Sleep Phase Disorder

Graphical network of the top 20 diseases related to Delayed Sleep Phase Disorder:



Diseases related to Delayed Sleep Phase Disorder

Symptoms & Phenotypes for Delayed Sleep Phase Disorder

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
delayed onset of sleep
sleep phase delay
fragmented sleep

Metabolic Features:
abnormal circadian rhythm
abnormal core temperature oscillation patterns


Clinical features from OMIM:

614163

Drugs & Therapeutics for Delayed Sleep Phase Disorder

Drugs for Delayed Sleep Phase Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 73-31-4 896
2 Antioxidants Phase 4,Phase 1,Not Applicable
3 Central Nervous System Depressants Phase 4,Phase 1,Not Applicable
4 Protective Agents Phase 4,Phase 1,Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD) Completed NCT01406691 Phase 4
2 Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome Completed NCT00834886 Phase 4
3 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder? Not yet recruiting NCT02962037 Phase 4
4 Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome Completed NCT00593736 Phase 2 Ramelteon;Ramelteon;Ramelteon;Placebo
5 Synchronization and Desynchronization Between Circadian Rhythms in Patients With Delayed Sleep Phase Syndrome (DSPS) Unknown status NCT00282061 Phase 1 Melatonin
6 Circadian Phase Assessments at Home Completed NCT01487252 Not Applicable
7 Melatonin Treatment for Induced Transient Insomnia Completed NCT00950885 Not Applicable
8 Does Cognitive Behaviour Therapy (CBT) Improve the Effect of Light Therapy Completed NCT01419938 Not Applicable
9 Effects of Light Treatment During Sleep on Young Men Completed NCT00796939 Not Applicable
10 Sleep Length and Circadian Regulation in Humans Completed NCT00843843 Not Applicable
11 Circadian Rhythms and Sleep in Familial DSPS and ASPS Recruiting NCT00246454
12 Light Sensitization Study Active, not recruiting NCT01327040 Not Applicable

Search NIH Clinical Center for Delayed Sleep Phase Disorder

Genetic Tests for Delayed Sleep Phase Disorder

Anatomical Context for Delayed Sleep Phase Disorder

MalaCards organs/tissues related to Delayed Sleep Phase Disorder:

41
Testes, Brain, Eye

Publications for Delayed Sleep Phase Disorder

Articles related to Delayed Sleep Phase Disorder:

(show top 50) (show all 101)
# Title Authors Year
1
Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder. ( 28364473 )
2017
2
Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder. ( 28388406 )
2017
3
Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder: An open-label trial. ( 27322730 )
2016
4
Prevalence of Circadian Misalignment and Its Association with Depressive Symptoms in Delayed Sleep Phase Disorder. ( 27692050 )
2016
5
Light Therapy With Scheduled Rise Times in Young Adults With Delayed Sleep Phase Disorder: Therapeutic Outcomes and Possible Predictors. ( 27712107 )
2016
6
Home dim light melatonin onsets with measures of compliance in delayed sleep phase disorder. ( 26847016 )
2016
7
The etiology of delayed sleep phase disorder. ( 26434674 )
2016
8
Delayed sleep phase disorder: clinical perspective with a focus on light therapy. ( 27110143 )
2016
9
Cognitive Behavioral Therapy as an Adjunct Treatment to Light Therapy for Delayed Sleep Phase Disorder in Young Adults: A Randomized Controlled Feasibility Study. ( 26244417 )
2016
10
Delayed sleep phase disorder in a Swedish cohort of adolescents and young adults: Prevalence and associated factors. ( 27537980 )
2016
11
Delayed sleep phase disorder risk is associated with absenteeism and impaired functioning. ( 29073375 )
2015
12
Out of synch with society: an update on delayed sleep phase disorder. ( 25160887 )
2014
13
Aripiprazole is effective for treatment of delayed sleep phase syndrome. ( 24992089 )
2014
14
The personality profile of young adults with delayed sleep phase disorder. ( 24283705 )
2014
15
A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep. ( 24144243 )
2014
16
Difficult morning awakening from rapid eye movement sleep and impaired cognitive function in delayed sleep phase disorder patients. ( 25156750 )
2014
17
Objective measures of sleep and dim light melatonin onset in adolescents and young adults with delayed sleep phase disorder compared to healthy controls. ( 23363423 )
2013
18
The endogenous circadian temperature period length (tau) in delayed sleep phase disorder compared to good sleepers. ( 23899423 )
2013
19
Obsessive-compulsive symptoms and characteristics in individuals with delayed sleep phase disorder. ( 24080675 )
2013
20
Delayed sleep phase syndrome in adolescents: prevalence and correlates in a large population based study. ( 24330358 )
2013
21
A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective and objective sleepiness and cognitive function. ( 24132057 )
2013
22
Delayed sleep phase syndrome: a forerunner of psychiatric distress. ( 24304991 )
2013
23
Delayed sleep phase disorder in youth. ( 24060912 )
2013
24
Delayed sleep phase disorder in an Australian school-based sample of adolescents. ( 23997706 )
2013
25
Delayed sleep phase syndrome is related to seasonal affective disorder. ( 21601293 )
2011
26
Relation between morningness-eveningness score and depressive symptoms among patients with delayed sleep phase syndrome. ( 21669551 )
2011
27
Delayed sleep phase syndrome and depression. ( 21704558 )
2011
28
Total sleep deprivation study in delayed sleep-phase syndrome. ( 23250347 )
2011
29
Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder. ( 20469812 )
2010
30
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. ( 20044310 )
2010
31
Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome? ( 19756996 )
2009
32
Sleep timing and circadian phase in delayed sleep phase syndrome. ( 19625733 )
2009
33
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. ( 18725185 )
2009
34
The prevalence of probable delayed-sleep-phase syndrome in students from junior high school to university in Tottori, Japan. ( 18719343 )
2008
35
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. ( 18078449 )
2008
36
Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice. ( 17445238 )
2007
37
Delayed sleep phase syndrome, ADHD, and bright light therapy. ( 17335340 )
2007
38
A prospective study of delayed sleep phase syndrome in patients with severe resistant obsessive-compulsive disorder. ( 18235868 )
2007
39
Attention bias for sleep-related stimuli in primary insomnia and delayed sleep phase syndrome using the dot-probe task. ( 17162988 )
2006
40
Who is pre-occupied with sleep? A comparison of attention bias in people with psychophysiological insomnia, delayed sleep phase syndrome and good sleepers using the induced change blindness paradigm. ( 16704577 )
2006
41
Circadian phase in delayed sleep phase syndrome: predictors and temporal stability across multiple assessments. ( 16944677 )
2006
42
Melatonin treatment in adolescents with delayed sleep phase syndrome. ( 17041168 )
2006
43
Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? ( 15700718 )
2005
44
Timed melatonin treatment for delayed sleep phase syndrome: the importance of knowing circadian phase. ( 16295202 )
2005
45
Phase-dependent treatment of delayed sleep phase syndrome with melatonin. ( 16295212 )
2005
46
Delayed sleep phase syndrome: pathophysiology and treatment options. ( 15532214 )
2004
47
Sleep and circadian rhythm disturbances in patients with delayed sleep phase syndrome. ( 14572116 )
2003
48
The psychological aspects of patients with delayed sleep phase syndrome (DSPS). ( 14592284 )
2003
49
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. ( 12841365 )
2003
50
Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. ( 12736803 )
2003

Variations for Delayed Sleep Phase Disorder

ClinVar genetic disease variations for Delayed Sleep Phase Disorder:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CRY1 NM_004075.4(CRY1): c.1657+3A> C single nucleotide variant risk factor rs184039278 GRCh38 Chromosome 12, 106992962: 106992962
2 CRY1 NM_004075.4(CRY1): c.1657+3A> C single nucleotide variant risk factor rs184039278 GRCh37 Chromosome 12, 107386740: 107386740

Expression for Delayed Sleep Phase Disorder

Search GEO for disease gene expression data for Delayed Sleep Phase Disorder.

Pathways for Delayed Sleep Phase Disorder

Pathways related to Delayed Sleep Phase Disorder according to KEGG:

37
# Name Kegg Source Accession
1 Tryptophan metabolism hsa00380
2 Metabolic pathways hsa01100

GO Terms for Delayed Sleep Phase Disorder

Biological processes related to Delayed Sleep Phase Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.85 CLOCK CRY1 PER2 PER3
2 transcription, DNA-templated GO:0006351 9.84 CLOCK CRY1 PER2 PER3
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.7 CRY1 PER2 PER3
4 negative regulation of transcription, DNA-templated GO:0045892 9.69 CLOCK CRY1 PER2
5 regulation of insulin secretion GO:0050796 9.49 CLOCK PER2
6 regulation of circadian rhythm GO:0042752 9.48 CRY1 PER2
7 negative regulation of protein ubiquitination GO:0031397 9.46 CRY1 PER2
8 rhythmic process GO:0048511 9.46 CLOCK CRY1 PER2 PER3
9 gluconeogenesis GO:0006094 9.43 CRY1 PER2
10 entrainment of circadian clock by photoperiod GO:0043153 9.43 CRY1 PER2 PER3
11 response to light stimulus GO:0009416 9.4 PER2 PER3
12 negative regulation of circadian rhythm GO:0042754 9.37 CRY1 PER2
13 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.32 CLOCK CRY1
14 circadian rhythm GO:0007623 9.26 CLOCK CRY1 PER2 PER3
15 circadian regulation of gene expression GO:0032922 8.92 CLOCK CRY1 PER2 PER3

Molecular functions related to Delayed Sleep Phase Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 9.4 CRY1 PER3
2 transcription regulatory region sequence-specific DNA binding GO:0000976 9.37 PER2 PER3
3 transcription factor binding GO:0008134 9.33 CRY1 PER2 PER3
4 core promoter binding GO:0001047 9.32 CLOCK CRY1
5 core promoter sequence-specific DNA binding GO:0001046 9.26 CLOCK CRY1
6 transcription corepressor binding GO:0001222 8.96 PER2 PER3
7 transcription factor activity, transcription factor binding GO:0000989 8.8 CRY1 PER2 PER3

Sources for Delayed Sleep Phase Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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