MCID: DLS001
MIFTS: 41

Delusional Disorder

Categories: Mental diseases

Aliases & Classifications for Delusional Disorder

MalaCards integrated aliases for Delusional Disorder:

Name: Delusional Disorder 12 76 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:778
ICD10 33 F22 F22.0
ICD9CM 35 297.1
MeSH 44 D012563
NCIt 50 C94379
SNOMED-CT 68 48500005
UMLS 73 C0011251

Summaries for Delusional Disorder

Disease Ontology : 12 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards based summary : Delusional Disorder is related to schizoaffective disorder and schizophrenia. An important gene associated with Delusional Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Circadian entrainment and Beta-Adrenergic Signaling. The drugs Dopamine and Ziprasidone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and liver.

Wikipedia : 76 Delusional disorder is a generally rare mental illness in which the patient presents delusions, but with... more...

Related Diseases for Delusional Disorder

Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 schizoaffective disorder 31.0 DRD2 DRD3
2 schizophrenia 30.8 CYP2D6 DRD2 DRD3 DRD4 TH
3 personality disorder 30.0 DRD2 DRD4
4 alcohol abuse 29.6 DRD2 DRD3 DRD4
5 alcohol dependence 29.6 DRD2 DRD3 DRD4
6 mood disorder 29.4 DRD2 DRD3 DRD4 TH
7 bipolar disorder 29.3 DRD2 DRD3 DRD4 TH
8 autism 29.3 DRD2 DRD3 DRD4 TH
9 major depressive disorder 29.3 CYP2D6 DRD2 DRD3 DRD4
10 psychotic disorder 29.3 CYP2D6 DRD2 DRD3 DRD4 HLA-A
11 capgras syndrome 11.4
12 koro 11.0
13 paranoid schizophrenia 10.7
14 body dysmorphic disorder 10.1
15 polysubstance abuse 10.1 DRD2 DRD3
16 bruxism 10.1 DRD2 DRD3
17 galactorrhea 10.1 CYP2D6 DRD2
18 cocaine dependence 10.1 DRD2 DRD3
19 tic disorder 10.1 DRD2 DRD4
20 neuroleptic malignant syndrome 10.1 CYP2D6 DRD2
21 gastroparesis 10.1 CYP2D6 DRD2
22 schizotypal personality disorder 10.0
23 early-onset schizophrenia 10.0
24 multiple system atrophy 1 10.0 DRD2 TH
25 drug dependence 10.0 DRD2 DRD3
26 heroin dependence 10.0 DRD2 DRD4
27 supranuclear palsy, progressive, 1 10.0 DRD2 TH
28 oppositional defiant disorder 10.0 DRD2 DRD4
29 conduct disorder 10.0 DRD2 DRD4
30 alpha thalassemia-intellectual disability syndrome type 1 10.0 DRD4 TH
31 anorexia nervosa 10.0
32 dementia 10.0
33 depression 10.0
34 opiate dependence 10.0 DRD2 DRD3 TH
35 separation anxiety disorder 10.0 DRD4 HLA-A
36 movement disease 10.0 DRD2 DRD3 TH
37 restless legs syndrome 10.0 DRD2 DRD3 TH
38 tardive dyskinesia 10.0 CYP2D6 DRD2 DRD3
39 impulse control disorder 9.9 DRD2 DRD3 DRD4
40 pathological gambling 9.9 DRD2 DRD3 DRD4
41 migraine without aura 9.9 DRD2 DRD3 DRD4
42 autoimmune hepatitis 9.9 CYP2D6 HLA-A
43 dementia, lewy body 9.9 CYP2D6 TH
44 corpus callosum, agenesis of 9.8
45 hydrocephalus, normal-pressure 9.8
46 phenylketonuria 9.8
47 cognitive function 1, social 9.8
48 paine syndrome 9.8
49 trimethylaminuria 9.8
50 anxiety 9.8

Comorbidity relations with Delusional Disorder via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Alzheimer Disease
Anxiety Deficiency Anemia
Dysthymic Disorder Hypothyroidism
Major Depressive Disorder Paranoid Personality Disorder
Paranoid Schizophrenia Parkinson Disease, Late-Onset
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to Delusional Disorder

Symptoms & Phenotypes for Delusional Disorder

Drugs & Therapeutics for Delusional Disorder

Drugs for Delusional Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
2
Ziprasidone Approved Phase 4 146939-27-7 60854
3
Cycloserine Approved Phase 4 68-41-7 6234 401
4 Antipsychotic Agents Phase 4,Phase 2,Not Applicable
5 Psychotropic Drugs Phase 4,Not Applicable
6 Serotonin Agents Phase 4,Not Applicable
7 Central Nervous System Depressants Phase 4,Not Applicable
8 Dopamine Antagonists Phase 4,Not Applicable
9 Neurotransmitter Agents Phase 4,Not Applicable
10 Tranquilizing Agents Phase 4,Not Applicable
11 Serotonin Antagonists Phase 4,Not Applicable
12 Dopamine Agents Phase 4,Not Applicable
13 Anti-Infective Agents Phase 4
14 Anti-Infective Agents, Urinary Phase 4
15 Antitubercular Agents Phase 4
16 Anti-Bacterial Agents Phase 4
17 Renal Agents Phase 4
18 Antibiotics, Antitubercular Phase 4
19 Antimetabolites Phase 4
20 S 20098 Phase 4
21 Antidepressive Agents Phase 4
22 Hypnotics and Sedatives Phase 4
23 Quetiapine Fumarate Phase 4 111974-72-2
24
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
25
Aripiprazole Approved, Investigational 129722-12-9 60795
26
Olanzapine Approved, Investigational ,Not Applicable 132539-06-1 4585
27
Risperidone Approved, Investigational ,Not Applicable 106266-06-2 5073
28 Tangerine Approved
29
Ethanol Approved 64-17-5 702
30 Raclopride Investigational Not Applicable 84225-95-6
31 Neurotransmitter Uptake Inhibitors ,Not Applicable
32 Autonomic Agents ,Not Applicable
33 Antiemetics ,Not Applicable
34 Peripheral Nervous System Agents ,Not Applicable
35 Gastrointestinal Agents ,Not Applicable
36 Serotonin Uptake Inhibitors ,Not Applicable
37 Sympathomimetics Not Applicable
38 Cardiotonic Agents Not Applicable
39 Protective Agents Not Applicable
40 Parasympatholytics Not Applicable
41
Benztropine Not Applicable 86-13-5 6832
42 Antiparkinson Agents Not Applicable
43 Muscarinic Antagonists Not Applicable
44 Cholinergic Antagonists Not Applicable
45 Dopamine Uptake Inhibitors Not Applicable
46 Cholinergic Agents Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 A Study of the Efficacy and Safety of Intramuscular Ziprasidone Followed by Oral Ziprasidone for the Treatment of Psychosis Completed NCT00644800 Phase 4 Ziprasidone
2 D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions Completed NCT01981759 Phase 4 D-Cycloserine;Placebo
3 Agomelatine Treatment of Depression in Schizophrenia (AGOPSYCH) Completed NCT01822418 Phase 4 agomelatine
4 Research Into Antipsychotic Discontinuation and Reduction Trial Recruiting NCT03559426 Phase 4 Antipsychotic Reduction;Antipsychotic Maintenance
5 Schizophrenic Patients in Integrated Care Terminated NCT00681629 Phase 4 Quetiapine XR
6 Trial of Cognitive Behavioral Therapy for Schizophrenia Unknown status NCT00300651 Phase 3
7 Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis Unknown status NCT00465920 Phase 2
8 Pilot-trial of Emotion-focused Cognitive Behavior Therapy for Patients With Schizophrenia Active, not recruiting NCT02787122 Phase 2
9 Cognitive Determinants of Psychoeducation and Information in Psychoses Unknown status NCT00646256 Not Applicable
10 Improving Cognitive Function of Aripiprazole in Treating Adolescents and Young Adults With Psychotic Disorder Unknown status NCT00541502
11 Cross-Sectional Iloperidone IVGTT Unknown status NCT01686815
12 Acceptance and Commitment Therapy for Delusions Completed NCT00657631 Not Applicable
13 Schizophrenia, Antipsychotic Treatment and the Risk for Diabetes Mellitus Completed NCT00222807
14 Attributional Style and Parkinson's Disease Completed NCT03371277 Not Applicable
15 Response of Psychiatric Outpatients to the Great East Japan Earthquake Completed NCT01533064
16 Multi-disciplinary Treatment for Patients Experiencing First Episode of Psychosis Completed NCT01216891 Not Applicable
17 Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia. Completed NCT00716755 Not Applicable Risperidone/Olanzapine and PET scans
18 Factors of Importance for the Subjective and Objective Burden of Informal Caregivers to Patients With Functional Psychoses - a Descriptive and Comparative Study Completed NCT00670371
19 Vocal Acoustic Biomarkers in Depression Completed NCT00844948
20 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
21 The Efficacy of Using a Smartphone App to Support Shared Decision Making in People With a Diagnosis of Schizophrenia Recruiting NCT03554655 Not Applicable
22 Integrated Care in Psychotic Disorders With Severe Mental Illness Recruiting NCT01888627 Not Applicable
23 Skills for Wellness Recruiting NCT01980147 Not Applicable
24 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
25 Anticholinergic Burden in Schizophrenia Terminated NCT00715377 Not Applicable Benztropine
26 Schizophrenic Patients Taking Part in Integrated Care Program Terminated NCT00617214

Search NIH Clinical Center for Delusional Disorder

Genetic Tests for Delusional Disorder

Anatomical Context for Delusional Disorder

MalaCards organs/tissues related to Delusional Disorder:

41
Eye, Brain, Liver, Pituitary

Publications for Delusional Disorder

Articles related to Delusional Disorder:

(show top 50) (show all 192)
# Title Authors Year
1
Successful Treatment of Delusional Disorder With Aripiprazole Long-Acting Injection. ( 29901565 )
2018
2
The impact of depressive symptoms on the clinical presentation of Persistent Delusional Disorder. ( 29248867 )
2018
3
A Systematic Review of Methods for the Measurement of Antipsychotic Adherence in Delusional Disorder. ( 29851708 )
2018
4
A systematic review of the operational definitions for antipsychotic response in delusional disorder. ( 29912058 )
2018
5
Delusional disorder in brain abscess: Searching the missing link. ( 29655049 )
2018
6
Delusional disorder: The role of personality and emotions on delusional ideation. ( 30005180 )
2018
7
Trihexyphenidyl Misuse in Delusional Disorder. ( 30069107 )
2018
8
Short-term outcome of first episode delusional disorder in an early intervention population. ( 30195583 )
2018
9
Cognition and functionality in delusional disorder. ( 30388425 )
2018
10
Delusional Disorder Arising From a CNS Neoplasm. ( 28422607 )
2017
11
TAILOR - tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial. ( 28962668 )
2017
12
Risperidone versus olanzapine in the acute treatment of Persistent Delusional Disorder: A retrospective analysis. ( 28411574 )
2017
13
A Psychopathological Comparison between Delusional Disorder and Schizophrenia. ( 28595494 )
2017
14
Gender Differences in Persistent Delusional Disorder. ( 28515568 )
2017
15
Delusional Disorder, Erotomanic Type, Exacerbated by Social Media Use. ( 28367347 )
2017
16
The comprehensive treatment of delusional disorder. ( 28476504 )
2017
17
A Systematic Review on the Pharmacological Treatment of Delusional Disorder. ( 27811554 )
2016
18
What is the Evidence for Treating Delusional Disorder? ( 27712246 )
2016
19
Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder. ( 27335526 )
2016
20
Letter to the Editor: Comparing delusional disorder and schizophrenia: a comment on Hui et al. (2015). ( 26690961 )
2016
21
Antipsychotic response in delusional disorder and schizophrenia: a prospective cohort study. ( 27388104 )
2016
22
Clinical Presentation and Course of Persistent Delusional Disorder: Data From a Tertiary Care Center in India. ( 27247844 )
2016
23
Characteristics and clinical correlates of dimensions of delusional experience in schizophrenia and delusional disorder. ( 27261418 )
2016
24
Folie a deux and delusional disorder by proxy: an atypical presentation. ( 27245561 )
2016
25
Delusional disorder and schizophrenia: a comparative study across multiple domains. ( 27468631 )
2016
26
Delusional Disorder in a Patient with Corpus Callosum Agenesis. ( 28208982 )
2016
27
Structural and functional brain changes in delusional disorder. ( 26382955 )
2016
28
Treatments for delusional disorder. ( 25997589 )
2015
29
Therapeutic approach to delusional disorder based on psychopathological complexity: proposal for a decision model. ( 25679132 )
2015
30
Unexpected subthreshold autism spectrum in a 25-year-old male stalker hospitalized for delusional disorder: a case report. ( 26031384 )
2015
31
Delusional disorder and schizophrenia: a comparison of the neurocognitive and clinical characteristics in first-episode patients. ( 26036591 )
2015
32
Normal pressure hydrocephalus presenting as delusional disorder. ( 26257493 )
2015
33
Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course. ( 26600949 )
2015
34
Treatments for Delusional Disorder. ( 26209547 )
2015
35
The prevalence of delusional disorder in prison. ( 25770283 )
2015
36
Paranoid delusional disorder follows social anxiety disorder in a long-term case series: evolutionary perspective. ( 26034873 )
2015
37
Letter to the Editor: Comparing delusional disorder and schizophrenia: a comment on Hui et al. (2015) - a reply. ( 26691196 )
2015
38
A dimensional comparison between delusional disorder, schizophrenia and schizoaffective disorder. ( 26585220 )
2015
39
Aripiprazole in difficult-to-treat delusional disorder with co-morbid epilepsy. ( 24779650 )
2014
40
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. ( 25391585 )
2014
41
Delusional Disorder as a Partial Psychosis. ( 24421383 )
2014
42
Phenotypic cognitive impairment in late-onset delusional disorder. ( 24524668 )
2014
43
Suicidal ideation and suicidal behaviour in delusional disorder: a clinical overview. ( 24829903 )
2014
44
Supersensitivity psychosis and its response to asenapine in a patient with delusional disorder. ( 25478273 )
2014
45
Atypical delusional content in a case of persistent delusional disorder: freud revisited. ( 25336780 )
2014
46
Delusional disorder: an unusual presentation. ( 25336783 )
2014
47
Psy-feld: An Innovative Didactic Using the TV Show Seinfeld to Teach Delusional Disorder Subtypes. ( 25410045 )
2014
48
Russell's sign in persistent delusional disorder: a case report. ( 25093783 )
2014
49
Delusional disorder: no gender differences in age at onset, suicidal ideation, or suicidal behavior. ( 24554277 )
2014
50
Reproductive variables and gynaecological service use in delusional disorder outpatients. ( 24378254 )
2013

Variations for Delusional Disorder

Expression for Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for Delusional Disorder

GO Terms for Delusional Disorder

Cellular components related to Delusional Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.67 DRD2 DRD3 DRD4 HLA-A
2 dendrite GO:0030425 9.5 DRD2 DRD4 TH
3 GABA-ergic synapse GO:0098982 9.26 DRD2 DRD3
4 endocytic vesicle GO:0030139 9.16 DRD2 DRD3
5 glutamatergic synapse GO:0098978 9.13 DRD2 DRD3 DRD4
6 dopaminergic synapse GO:0098691 8.62 DRD2 DRD3

Biological processes related to Delusional Disorder according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.86 DRD2 DRD3 PNP TH
2 response to ethanol GO:0045471 9.77 DRD2 DRD3 TH
3 locomotory behavior GO:0007626 9.75 DRD2 DRD3 TH
4 social behavior GO:0035176 9.71 DRD3 DRD4 TH
5 learning GO:0007612 9.68 DRD3 TH
6 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.67 DRD2 DRD3
7 circadian regulation of gene expression GO:0032922 9.67 DRD2 DRD3
8 negative regulation of protein kinase B signaling GO:0051898 9.67 DRD2 DRD3
9 visual learning GO:0008542 9.66 DRD2 DRD3
10 response to cocaine GO:0042220 9.66 DRD2 DRD3
11 response to nicotine GO:0035094 9.65 DRD2 TH
12 pigmentation GO:0043473 9.65 DRD2 TH
13 positive regulation of cytokinesis GO:0032467 9.65 DRD2 DRD3
14 response to morphine GO:0043278 9.64 DRD2 DRD3
15 negative regulation of blood pressure GO:0045776 9.64 DRD2 DRD3
16 response to light stimulus GO:0009416 9.63 DRD2 TH
17 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.63 DRD2 DRD3
18 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD3 DRD4
19 prepulse inhibition GO:0060134 9.62 DRD2 DRD3
20 positive regulation of renal sodium excretion GO:0035815 9.62 DRD2 DRD3
21 G protein-coupled receptor internalization GO:0002031 9.61 DRD2 DRD3
22 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.61 DRD3 DRD4
23 behavioral response to cocaine GO:0048148 9.61 DRD2 DRD3 DRD4
24 behavioral response to ethanol GO:0048149 9.59 DRD2 DRD4
25 negative regulation of voltage-gated calcium channel activity GO:1901386 9.58 DRD2 DRD4
26 dopamine receptor signaling pathway GO:0007212 9.58 DRD2 DRD3 DRD4
27 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.57 DRD2 DRD3
28 negative regulation of dopamine receptor signaling pathway GO:0060160 9.55 DRD2 DRD3
29 negative regulation of protein secretion GO:0050709 9.54 DRD2 DRD3 DRD4
30 acid secretion GO:0046717 9.52 DRD2 DRD3
31 isoquinoline alkaloid metabolic process GO:0033076 9.51 CYP2D6 TH
32 synaptic transmission, dopaminergic GO:0001963 9.5 DRD2 DRD3 TH
33 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.49 DRD2 DRD4
34 regulation of locomotion involved in locomotory behavior GO:0090325 9.48 DRD2 DRD3
35 dopamine metabolic process GO:0042417 9.43 DRD2 DRD3 DRD4
36 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.33 DRD2 DRD3 DRD4
37 response to amphetamine GO:0001975 9.26 DRD2 DRD3 DRD4 TH
38 response to histamine GO:0034776 8.8 DRD2 DRD3 DRD4

Molecular functions related to Delusional Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.43 DRD2 DRD3 DRD4
2 monooxygenase activity GO:0004497 9.37 CYP2D6 TH
3 drug binding GO:0008144 9.35 CYP2D6 DRD2 DRD3 DRD4 PNP
4 dopamine neurotransmitter receptor activity GO:0004952 9.33 DRD2 DRD3 DRD4
5 adrenergic receptor activity GO:0004935 9.32 DRD2 DRD3
6 dopamine binding GO:0035240 8.92 DRD2 DRD3 DRD4 TH

Sources for Delusional Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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