MCID: DLS001
MIFTS: 41

Delusional Disorder

Categories: Mental diseases

Aliases & Classifications for Delusional Disorder

MalaCards integrated aliases for Delusional Disorder:

Name: Delusional Disorder 12 76 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:778
ICD10 33 F22 F22.0
ICD9CM 35 297.1
MeSH 44 D012563
NCIt 50 C94379
SNOMED-CT 68 192330005 48500005
UMLS 73 C0011251

Summaries for Delusional Disorder

Disease Ontology : 12 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards based summary : Delusional Disorder is related to schizoaffective disorder and schizophrenia. An important gene associated with Delusional Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Circadian entrainment and Beta-Adrenergic Signaling. The drugs Dopamine and Ziprasidone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and pituitary.

Wikipedia : 76 Delusional disorder is a generally rare mental illness in which the patient presents delusions, but with... more...

Related Diseases for Delusional Disorder

Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 schizoaffective disorder 30.6 DRD2 DRD3
2 schizophrenia 29.8 DRD2 DRD3 DRD4 TH
3 personality disorder 29.4 DRD2 DRD3 DRD4
4 alcohol abuse 29.1 DRD2 DRD3 DRD4
5 major depressive disorder 29.0 DRD2 DRD3 DRD4
6 alcohol dependence 29.0 DRD2 DRD3 DRD4
7 early-onset schizophrenia 28.7 DRD2 DRD3 DRD4 TH
8 mood disorder 28.4 DRD2 DRD3 DRD4 TH
9 bipolar disorder 28.3 DRD2 DRD3 DRD4 TH
10 psychotic disorder 28.3 DRD2 DRD3 DRD4 HLA-A
11 autism 28.2 DRD2 DRD3 DRD4 TH
12 capgras syndrome 11.2
13 koro 10.9
14 paranoid schizophrenia 10.5
15 polysubstance abuse 10.4 DRD2 DRD3
16 tardive dyskinesia 10.4 DRD2 DRD3
17 cocaine dependence 10.2 DRD2 DRD3
18 dystonia 11, myoclonic 10.2 DRD2 TH
19 multiple system atrophy 1 10.1 DRD2 TH
20 heroin dependence 10.1 DRD2 DRD4
21 oppositional defiant disorder 10.1 DRD2 DRD4
22 tic disorder 10.1 DRD2 DRD4
23 supranuclear palsy, progressive, 1 10.0 DRD2 TH
24 drug dependence 10.0 DRD2 DRD3
25 aging 10.0
26 body dysmorphic disorder 10.0
27 opiate dependence 9.9 DRD2 DRD3 TH
28 depression 9.9
29 movement disease 9.9 DRD2 DRD3 TH
30 schizotypal personality disorder 9.9
31 conduct disorder 9.9 DRD2 DRD4
32 restless legs syndrome 9.9 DRD2 DRD3 TH
33 anorexia nervosa 9.9
34 dementia 9.9
35 separation anxiety disorder 9.8 DRD4 HLA-A
36 impulse control disorder 9.8 DRD2 DRD3 DRD4
37 pathological gambling 9.8 DRD2 DRD3 DRD4
38 migraine without aura 9.7 DRD2 DRD3 DRD4
39 substance abuse 9.7 DRD2 DRD3 DRD4
40 substance dependence 9.7 DRD2 DRD3 DRD4
41 corpus callosum, agenesis of 9.7
42 hydrocephalus, normal-pressure 9.7
43 phenylketonuria 9.7
44 cognitive function 1, social 9.7
45 paine syndrome 9.7
46 trimethylaminuria 9.7
47 anxiety 9.7
48 hyperprolactinemia 9.7
49 charcot-marie-tooth disease 9.7
50 hydrocephalus 9.7

Comorbidity relations with Delusional Disorder via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Alzheimer Disease
Anxiety Deficiency Anemia
Dysthymic Disorder Hypothyroidism
Major Depressive Disorder Paranoid Personality Disorder
Paranoid Schizophrenia Parkinson Disease, Late-Onset
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to Delusional Disorder

Symptoms & Phenotypes for Delusional Disorder

Drugs & Therapeutics for Delusional Disorder

Drugs for Delusional Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
2
Ziprasidone Approved Phase 4 146939-27-7 60854
3
Cycloserine Approved Phase 4 68-41-7 401 6234
4 Central Nervous System Depressants Phase 4,Not Applicable
5 Serotonin Agents Phase 4,Not Applicable
6 Serotonin Antagonists Phase 4,Not Applicable
7 Neurotransmitter Agents Phase 4,Not Applicable
8 Tranquilizing Agents Phase 4,Not Applicable
9 Dopamine Agents Phase 4,Not Applicable
10 Dopamine Antagonists Phase 4,Not Applicable
11 Antipsychotic Agents Phase 4,Phase 2,Not Applicable
12 Psychotropic Drugs Phase 4,Not Applicable
13 Renal Agents Phase 4
14 S 20098 Phase 4
15 Anti-Bacterial Agents Phase 4
16 Hypnotics and Sedatives Phase 4
17 Antibiotics, Antitubercular Phase 4
18 Antidepressive Agents Phase 4
19 Anti-Infective Agents Phase 4
20 Antitubercular Agents Phase 4
21 Antimetabolites Phase 4
22 Quetiapine Fumarate Phase 4 111974-72-2
23
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
24
Olanzapine Approved, Investigational ,Not Applicable 132539-06-1 4585
25
Risperidone Approved, Investigational ,Not Applicable 106266-06-2 5073
26
Aripiprazole Approved, Investigational 129722-12-9 60795
27
Ethanol Approved 64-17-5 702
28 Tangerine Approved, Nutraceutical
29 Raclopride Investigational Not Applicable 84225-95-6
30 Serotonin Uptake Inhibitors ,Not Applicable
31 Gastrointestinal Agents ,Not Applicable
32 Neurotransmitter Uptake Inhibitors ,Not Applicable
33 Peripheral Nervous System Agents ,Not Applicable
34 Antiemetics ,Not Applicable
35 Autonomic Agents ,Not Applicable
36 Protective Agents Not Applicable
37
Benztropine Not Applicable 86-13-5 6832
38 Cholinergic Agents Not Applicable
39 Muscarinic Antagonists Not Applicable
40 Cholinergic Antagonists Not Applicable
41 Parasympatholytics Not Applicable
42 Dopamine Uptake Inhibitors Not Applicable
43 Antiparkinson Agents Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 A Study of the Efficacy and Safety of Intramuscular Ziprasidone Followed by Oral Ziprasidone for the Treatment of Psychosis Completed NCT00644800 Phase 4 Ziprasidone
2 D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions Completed NCT01981759 Phase 4 D-Cycloserine;Placebo
3 Agomelatine Treatment of Depression in Schizophrenia (AGOPSYCH) Completed NCT01822418 Phase 4 agomelatine
4 Research Into Antipsychotic Discontinuation and Reduction Recruiting NCT03559426 Phase 4 Antipsychotic Reduction/Discontinuation;Maintenance
5 Schizophrenic Patients in Integrated Care Terminated NCT00681629 Phase 4 Quetiapine XR
6 Trial of Cognitive Behavioral Therapy for Schizophrenia Unknown status NCT00300651 Phase 3
7 Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis Unknown status NCT00465920 Phase 2
8 Pilot-trial of Emotion-focused Cognitive Behavior Therapy for Patients With Schizophrenia Active, not recruiting NCT02787122 Phase 2
9 Cognitive Determinants of Psychoeducation and Information in Psychoses Unknown status NCT00646256 Not Applicable
10 Improving Cognitive Function of Aripiprazole in Treating Adolescents and Young Adults With Psychotic Disorder Unknown status NCT00541502
11 Cross-Sectional Iloperidone IVGTT Unknown status NCT01686815
12 Acceptance and Commitment Therapy for Delusions Completed NCT00657631 Not Applicable
13 Schizophrenia, Antipsychotic Treatment and the Risk for Diabetes Mellitus Completed NCT00222807
14 Response of Psychiatric Outpatients to the Great East Japan Earthquake Completed NCT01533064
15 Multi-disciplinary Treatment for Patients Experiencing First Episode of Psychosis Completed NCT01216891 Not Applicable
16 Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia. Completed NCT00716755 Not Applicable Risperidone/Olanzapine and PET scans
17 Factors of Importance for the Subjective and Objective Burden of Informal Caregivers to Patients With Functional Psychoses - a Descriptive and Comparative Study Completed NCT00670371
18 Vocal Acoustic Biomarkers in Depression Completed NCT00844948
19 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
20 Attributional Style and Parkinson's Disease Recruiting NCT03371277 Not Applicable
21 Integrated Care in Psychotic Disorders With Severe Mental Illness Recruiting NCT01888627 Not Applicable
22 Skills for Wellness Recruiting NCT01980147 Not Applicable
23 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
24 The Efficacy of Using a Smartphone App to Support Shared Decision Making in People With a Diagnosis of Schizophrenia Not yet recruiting NCT03554655 Not Applicable
25 Anticholinergic Burden in Schizophrenia Terminated NCT00715377 Not Applicable Benztropine
26 Schizophrenic Patients Taking Part in Integrated Care Program Terminated NCT00617214

Search NIH Clinical Center for Delusional Disorder

Genetic Tests for Delusional Disorder

Anatomical Context for Delusional Disorder

MalaCards organs/tissues related to Delusional Disorder:

41
Eye, Brain, Pituitary, Liver

Publications for Delusional Disorder

Articles related to Delusional Disorder:

(show top 50) (show all 189)
# Title Authors Year
1
Successful Treatment of Delusional Disorder With Aripiprazole Long-Acting Injection. ( 29901565 )
2018
2
The impact of depressive symptoms on the clinical presentation of Persistent Delusional Disorder. ( 29248867 )
2018
3
A Systematic Review of Methods for the Measurement of Antipsychotic Adherence in Delusional Disorder. ( 29851708 )
2018
4
A systematic review of the operational definitions for antipsychotic response in delusional disorder. ( 29912058 )
2018
5
Delusional disorder in brain abscess: Searching the missing link. ( 29655049 )
2018
6
Delusional Disorder Arising From a CNS Neoplasm. ( 28422607 )
2017
7
TAILOR - tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial. ( 28962668 )
2017
8
Risperidone versus olanzapine in the acute treatment of Persistent Delusional Disorder: A retrospective analysis. ( 28411574 )
2017
9
A Psychopathological Comparison between Delusional Disorder and Schizophrenia. ( 28595494 )
2017
10
Gender Differences in Persistent Delusional Disorder. ( 28515568 )
2017
11
Delusional Disorder, Erotomanic Type, Exacerbated by Social Media Use. ( 28367347 )
2017
12
The comprehensive treatment of delusional disorder. ( 28476504 )
2017
13
A Systematic Review on the Pharmacological Treatment of Delusional Disorder. ( 27811554 )
2016
14
What is the Evidence for Treating Delusional Disorder? ( 27712246 )
2016
15
Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder. ( 27335526 )
2016
16
Letter to the Editor: Comparing delusional disorder and schizophrenia: a comment on Hui et al. (2015). ( 26690961 )
2016
17
Antipsychotic response in delusional disorder and schizophrenia: a prospective cohort study. ( 27388104 )
2016
18
Clinical Presentation and Course of Persistent Delusional Disorder: Data From a Tertiary Care Center in India. ( 27247844 )
2016
19
Characteristics and clinical correlates of dimensions of delusional experience in schizophrenia and delusional disorder. ( 27261418 )
2016
20
Folie a deux and delusional disorder by proxy: an atypical presentation. ( 27245561 )
2016
21
Delusional disorder and schizophrenia: a comparative study across multiple domains. ( 27468631 )
2016
22
Delusional Disorder in a Patient with Corpus Callosum Agenesis. ( 28208982 )
2016
23
Structural and functional brain changes in delusional disorder. ( 26382955 )
2016
24
Treatments for delusional disorder. ( 25997589 )
2015
25
Therapeutic approach to delusional disorder based on psychopathological complexity: proposal for a decision model. ( 25679132 )
2015
26
Unexpected subthreshold autism spectrum in a 25-year-old male stalker hospitalized for delusional disorder: a case report. ( 26031384 )
2015
27
Delusional disorder and schizophrenia: a comparison of the neurocognitive and clinical characteristics in first-episode patients. ( 26036591 )
2015
28
Normal pressure hydrocephalus presenting as delusional disorder. ( 26257493 )
2015
29
Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course. ( 26600949 )
2015
30
Treatments for Delusional Disorder. ( 26209547 )
2015
31
The prevalence of delusional disorder in prison. ( 25770283 )
2015
32
Paranoid delusional disorder follows social anxiety disorder in a long-term case series: evolutionary perspective. ( 26034873 )
2015
33
Letter to the Editor: Comparing delusional disorder and schizophrenia: a comment on Hui et al. (2015) - a reply. ( 26691196 )
2015
34
A dimensional comparison between delusional disorder, schizophrenia and schizoaffective disorder. ( 26585220 )
2015
35
Aripiprazole in difficult-to-treat delusional disorder with co-morbid epilepsy. ( 24779650 )
2014
36
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. ( 25391585 )
2014
37
Delusional Disorder as a Partial Psychosis. ( 24421383 )
2014
38
Phenotypic cognitive impairment in late-onset delusional disorder. ( 24524668 )
2014
39
Suicidal ideation and suicidal behaviour in delusional disorder: a clinical overview. ( 24829903 )
2014
40
Supersensitivity psychosis and its response to asenapine in a patient with delusional disorder. ( 25478273 )
2014
41
Atypical delusional content in a case of persistent delusional disorder: freud revisited. ( 25336780 )
2014
42
Delusional disorder: an unusual presentation. ( 25336783 )
2014
43
Psy-feld: An Innovative Didactic Using the TV Show Seinfeld to Teach Delusional Disorder Subtypes. ( 25410045 )
2014
44
Russell's sign in persistent delusional disorder: a case report. ( 25093783 )
2014
45
Delusional disorder: no gender differences in age at onset, suicidal ideation, or suicidal behavior. ( 24554277 )
2014
46
Reproductive variables and gynaecological service use in delusional disorder outpatients. ( 24378254 )
2013
47
Monosymptomatic Hypochondriacal Psychosis (somatic delusional disorder): a report of two cases. ( 23595526 )
2013
48
Low-dose quetiapine for the treatment of delusional disorder in a patient with Von Hippel-Lindau disease. ( 24026746 )
2013
49
Delusional disorder and oncology: review of the literature and case report. ( 24066407 )
2013
50
Prevalence of premorbid personality disorder and its clinical correlates in patients with delusional disorder. ( 23993136 )
2013

Variations for Delusional Disorder

Expression for Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for Delusional Disorder

GO Terms for Delusional Disorder

Cellular components related to Delusional Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle GO:0030139 8.62 DRD2 DRD3

Biological processes related to Delusional Disorder according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 DRD2 DRD3 PNP TH
2 response to ethanol GO:0045471 9.75 DRD2 DRD3 TH
3 locomotory behavior GO:0007626 9.74 DRD2 DRD3 TH
4 social behavior GO:0035176 9.71 DRD3 DRD4 TH
5 learning GO:0007612 9.67 DRD3 TH
6 negative regulation of protein kinase B signaling GO:0051898 9.66 DRD2 DRD3
7 circadian regulation of gene expression GO:0032922 9.66 DRD2 DRD3
8 visual learning GO:0008542 9.65 DRD2 DRD3
9 response to nicotine GO:0035094 9.65 DRD2 TH
10 pigmentation GO:0043473 9.65 DRD2 TH
11 response to cocaine GO:0042220 9.64 DRD2 DRD3
12 positive regulation of cytokinesis GO:0032467 9.64 DRD2 DRD3
13 response to morphine GO:0043278 9.63 DRD2 DRD3
14 negative regulation of blood pressure GO:0045776 9.63 DRD2 DRD3
15 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD3 DRD4
16 response to light stimulus GO:0009416 9.62 DRD2 TH
17 regulation of dopamine secretion GO:0014059 9.62 DRD2 DRD3
18 behavioral response to ethanol GO:0048149 9.61 DRD2 DRD4
19 positive regulation of renal sodium excretion GO:0035815 9.61 DRD2 DRD3
20 behavioral response to cocaine GO:0048148 9.61 DRD2 DRD3 DRD4
21 negative regulation of voltage-gated calcium channel activity GO:1901386 9.6 DRD2 DRD4
22 prepulse inhibition GO:0060134 9.59 DRD2 DRD3
23 G-protein coupled receptor internalization GO:0002031 9.58 DRD2 DRD3
24 dopamine receptor signaling pathway GO:0007212 9.58 DRD2 DRD3 DRD4
25 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.56 DRD2 DRD3
26 synaptic transmission, dopaminergic GO:0001963 9.54 DRD2 DRD3 TH
27 acid secretion GO:0046717 9.52 DRD2 DRD3
28 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.51 DRD2 DRD4
29 negative regulation of protein secretion GO:0050709 9.5 DRD2 DRD3 DRD4
30 negative regulation of dopamine receptor signaling pathway GO:0060160 9.49 DRD2 DRD3
31 regulation of locomotion involved in locomotory behavior GO:0090325 9.48 DRD2 DRD3
32 dopamine metabolic process GO:0042417 9.43 DRD2 DRD3 DRD4
33 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.33 DRD2 DRD3 DRD4
34 response to histamine GO:0034776 9.13 DRD2 DRD3 DRD4
35 response to amphetamine GO:0001975 8.92 DRD2 DRD3 DRD4 TH

Molecular functions related to Delusional Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 PNP
2 obsolete signal transducer activity GO:0004871 9.5 DRD2 DRD3 DRD4
3 monooxygenase activity GO:0004497 9.37 FMO3 TH
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
5 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD3 DRD4
6 dopamine binding GO:0035240 8.92 DRD2 DRD3 DRD4 TH

Sources for Delusional Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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