MCID: DMN012
MIFTS: 18

Dementia - Subcortical

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Dementia - Subcortical

MalaCards integrated aliases for Dementia - Subcortical:

Name: Dementia - Subcortical 55
Subcortical Dementia 74

Classifications:



External Ids:

UMLS 74 C4024935

Summaries for Dementia - Subcortical

NINDS : 55 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Dementia - Subcortical, also known as subcortical dementia, is related to dementia and vascular dementia. Affiliated tissues include brain, cortex and hypothalamus.

Wikipedia : 77 Subcortical dementia is a type of dementia characterised by slowness of mental processing,... more...

Related Diseases for Dementia - Subcortical

Diseases related to Dementia - Subcortical via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dementia 10.4
2 vascular dementia 10.2
3 frontotemporal dementia 10.0
4 binswanger's disease 10.0
5 encephalopathy 9.9
6 alzheimer disease 9.8
7 dementia, lewy body 9.8
8 hydrocephalus 9.8
9 vascular disease 9.8
10 subcortical arteriosclerotic encephalopathy 9.8

Graphical network of the top 20 diseases related to Dementia - Subcortical:



Diseases related to Dementia - Subcortical

Symptoms & Phenotypes for Dementia - Subcortical

Drugs & Therapeutics for Dementia - Subcortical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients Recruiting NCT03092804
2 The Effect of tDCS on Subcortical Brain Functioning Terminated NCT01602276 Not Applicable

Search NIH Clinical Center for Dementia - Subcortical

Genetic Tests for Dementia - Subcortical

Anatomical Context for Dementia - Subcortical

MalaCards organs/tissues related to Dementia - Subcortical:

42
Brain, Cortex, Hypothalamus

Publications for Dementia - Subcortical

Articles related to Dementia - Subcortical:

(show top 50) (show all 54)
# Title Authors Year
1
Word list and story recall elicit different patterns of memory deficit in patients with Alzheimer's disease, frontotemporal dementia, subcortical ischemic vascular disease, and Lewy body dementia. ( 23792693 )
2013
2
The applause sign in cortical and cortical-subcortical dementia. ( 23212756 )
2013
3
Impaired ideomotor limb apraxia in cortical and subcortical dementia: a comparison of Alzheimer's and Huntington's disease. ( 21212634 )
2011
4
Action versus animal naming fluency in subcortical dementia, frontal dementias, and Alzheimer's disease. ( 20104387 )
2010
5
Neuropsychology of cortical versus subcortical dementia syndromes. ( 17226737 )
2007
6
Cryptogenic multi-infarcts and cortico-subcortical dementia in a young adult. ( 17349661 )
2007
7
Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia. ( 16426093 )
2006
8
Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). ( 16093227 )
2005
9
Subcortical dementia: historical review and personal view. ( 16093223 )
2005
10
Cognitive and behavioral aspects of PSP since Steele, Richardson and Olszewski's description of PSP 40 years ago and Albert's delineation of the subcortical dementia 30 years ago. ( 16093225 )
2005
11
Irreversible subcortical dementia following high altitude illness. ( 15072719 )
2004
12
New V272A presenilin 1 mutation with very early onset subcortical dementia and parkinsonism. ( 15469450 )
2004
13
Characterizing alterations in executive functioning across distinct subtypes of cortical and subcortical dementia. ( 15595355 )
2004
14
Analyzing the subcortical dementia syndrome of Parkinson's disease using the RBANS. ( 14591446 )
2003
15
Chorea and rapidly progressive subcortical dementia in antiphospholipid syndrome. ( 17041404 )
2002
16
Recombinant interferon-alpha-induced chorea and frontal subcortical dementia. ( 11805273 )
2002
17
Recombinant interferon-alpha-induced chorea and frontal subcortical dementia. ( 12473790 )
2002
18
Subcortical dementia. ( 11823326 )
2002
19
Subcortical dementia associated with striking enlargement of the Virchow-Robin spaces and transneural degeneration of the left mammillo-thalamic tract. ( 11721096 )
2001
20
Alcohol dementia: "cortical" or "subcortical" dementia? ( 14590151 )
2001
21
The subcortical dementia of Huntington's disease. ( 9892059 )
1998
22
An association between subcortical dementia and pernicious anemia--a psychiatric mask. ( 9406742 )
1997
23
Dementia associated with periventricular and deep white matter alterations: a subtype of subcortical dementia. ( 14588416 )
1997
24
[Subcortical dementia versus bradyphrenia in Parkinson disease]. ( 8763663 )
1996
25
Subcortical dementia: a neurobehavioral approach. ( 8812000 )
1996
26
Memory and emotion processing in cortical and subcortical dementia. ( 8953234 )
1996
27
Clinical-pathological case conference: depression, behavior change, and subcortical dementia in a 57-year-old woman. ( 9081561 )
1996
28
Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. ( 7550604 )
1995
29
On the relation between exogenous and endogenous ERP component activity: evidence from patients with a subcortical dementia. ( 7649052 )
1995
30
Verbal fluency in cortical and subcortical dementia. ( 7738585 )
1995
31
Distinct cognitive profiles of cortical and subcortical dementia in advanced illness. ( 7746413 )
1995
32
Symptoms of depression in Alzheimer's disease, frontal lobe-type dementia, and subcortical dementia. ( 8595040 )
1995
33
Centrencephalic theory, the general learning system, and subcortical dementia. ( 8109876 )
1993
34
Primary Sjögren's syndrome with subcortical dementia. ( 8286835 )
1993
35
Subcortical dementia. ( 8343658 )
1993
36
Subcortical dementia. ( 8400952 )
1993
37
Is the concept of frontal-subcortical dementia relevant to schizophrenia? ( 1349250 )
1992
38
Effects of citicholine in subcortical dementia associated with Parkinson's disease assessed by quantified electroencephalography. ( 1468090 )
1992
39
Multi-infarct dementia, subcortical dementia, and hydrocephalus. ( 2035108 )
1991
40
Basal ganglia damage and subcortical dementia after possible insidious Coxsackie virus encephalitis. ( 3425221 )
1987
41
Subcortical dementia. ( 3813928 )
1987
42
Cortical vs subcortical dementia: neuropsychological similarities. ( 3813929 )
1987
43
EEG changes in subcortical dementia: a study of 22 patients with Steele-Richardson-Olszewski (SRO) syndrome. ( 2428577 )
1986
44
Subcortical dementia. Neuropsychology, neuropsychiatry, and pathophysiology. ( 2878699 )
1986
45
Subcortical dementia. ( 3083990 )
1986
46
Comparative neuropsychology of cortical and subcortical dementia. ( 3791055 )
1986
47
Cortical vs subcortical dementia. Neuropsychological differences. ( 3954623 )
1986
48
Subcortical dementia. Frontal cortex hypometabolism detected by positron tomography in patients with progressive supranuclear palsy. ( 3876136 )
1985
49
The concept of subcortical dementia. ( 2932922 )
1985
50
Subcortical dementia. Review of an emerging concept. ( 6235797 )
1984

Variations for Dementia - Subcortical

Expression for Dementia - Subcortical

Search GEO for disease gene expression data for Dementia - Subcortical.

Pathways for Dementia - Subcortical

GO Terms for Dementia - Subcortical

Sources for Dementia - Subcortical

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