MCID: DMN012
MIFTS: 15

Dementia - Subcortical

Categories: Mental diseases

Aliases & Classifications for Dementia - Subcortical

MalaCards integrated aliases for Dementia - Subcortical:

Name: Dementia - Subcortical 54
Subcortical Dementia 29 73

Classifications:



External Ids:

UMLS 73 C4024935

Summaries for Dementia - Subcortical

NINDS : 54 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Dementia - Subcortical, also known as subcortical dementia, is related to huntington disease-like 2 and dementia. Affiliated tissues include brain.

Wikipedia : 76 Subcortical dementia is a type of dementia characterised by slowness of mental processing,... more...

Related Diseases for Dementia - Subcortical

Diseases related to Dementia - Subcortical via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 huntington disease-like 2 11.0
2 dementia 9.9
3 vascular dementia 9.8
4 alzheimer disease 9.7
5 dementia, lewy body 9.7
6 frontotemporal dementia 9.7
7 vascular disease 9.7
8 frontotemporal dementia with parkinsonism-17 9.7

Graphical network of the top 20 diseases related to Dementia - Subcortical:



Diseases related to Dementia - Subcortical

Symptoms & Phenotypes for Dementia - Subcortical

Drugs & Therapeutics for Dementia - Subcortical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients Recruiting NCT03092804
2 The Effect of tDCS on Subcortical Brain Functioning Enrolling by invitation NCT01602276 Not Applicable

Search NIH Clinical Center for Dementia - Subcortical

Genetic Tests for Dementia - Subcortical

Genetic tests related to Dementia - Subcortical:

# Genetic test Affiliating Genes
1 Subcortical Dementia 29

Anatomical Context for Dementia - Subcortical

MalaCards organs/tissues related to Dementia - Subcortical:

41
Brain

Publications for Dementia - Subcortical

Articles related to Dementia - Subcortical:

# Title Authors Year
1
Word list and story recall elicit different patterns of memory deficit in patients with Alzheimer's disease, frontotemporal dementia, subcortical ischemic vascular disease, and Lewy body dementia. ( 23792693 )
2013
2
Impaired ideomotor limb apraxia in cortical and subcortical dementia: a comparison of Alzheimer's and Huntington's disease. ( 21212634 )
2011
3
Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia. ( 16426093 )
2006
4
Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). ( 16093227 )
2005
5
New V272A presenilin 1 mutation with very early onset subcortical dementia and parkinsonism. ( 15469450 )
2004
6
Recombinant interferon-alpha-induced chorea and frontal subcortical dementia. ( 12473790 )
2002
7
Chorea and rapidly progressive subcortical dementia in antiphospholipid syndrome. ( 17041404 )
2002
8
An association between subcortical dementia and pernicious anemia--a psychiatric mask. ( 9406742 )
1997
9
Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. ( 7550604 )
1995

Variations for Dementia - Subcortical

Expression for Dementia - Subcortical

Search GEO for disease gene expression data for Dementia - Subcortical.

Pathways for Dementia - Subcortical

GO Terms for Dementia - Subcortical

Sources for Dementia - Subcortical

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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