MCID: DMN012
MIFTS: 21

Dementia - Subcortical

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Dementia - Subcortical

MalaCards integrated aliases for Dementia - Subcortical:

Name: Dementia - Subcortical 53
Subcortical Dementia 71

Classifications:



External Ids:

UMLS 71 C4024935

Summaries for Dementia - Subcortical

NINDS : 53 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.

MalaCards based summary : Dementia - Subcortical, also known as subcortical dementia, is related to dementia and vascular dementia. The drugs Rasagiline and Neuroprotective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and thalamus.

Wikipedia : 74 Subcortical dementias includes those diseases which predominantly affects the basal ganglia along with... more...

Related Diseases for Dementia - Subcortical

Diseases related to Dementia - Subcortical via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 dementia 10.5
2 vascular dementia 10.3
3 vascular disease 10.1
4 binswanger's disease 10.0
5 supranuclear palsy, progressive, 1 9.9
6 cerebrovascular disease 9.9
7 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.8
8 dementia, lewy body 9.8
9 huntington disease 9.8
10 frontotemporal dementia 9.8
11 vitamin b12 deficiency 9.8
12 aphasia 9.8
13 apraxia 9.8
14 hydrocephalus 9.8
15 hypothyroidism 9.8
16 normal pressure hydrocephalus 9.8
17 lipid metabolism disorder 9.8
18 agnosia 9.8
19 syphilis 9.8
20 head injury 9.8
21 subcortical arteriosclerotic encephalopathy 9.8

Graphical network of the top 20 diseases related to Dementia - Subcortical:



Diseases related to Dementia - Subcortical

Symptoms & Phenotypes for Dementia - Subcortical

Drugs & Therapeutics for Dementia - Subcortical

Drugs for Dementia - Subcortical (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rasagiline Approved Phase 3 136236-51-6 3052776
2 Neuroprotective Agents Phase 3
3 Monoamine Oxidase Inhibitors Phase 3
4 Protective Agents Phase 3
5
Udenafil Approved, Investigational Phase 2 268203-93-6 6918523
6 Phosphodiesterase 5 Inhibitors Phase 2
7 Phosphodiesterase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of Rasagiline in Subjects With Progressive Supranuclear Palsy (Phase III) Terminated NCT01187888 Phase 3 Rasagiline;Sugar pill
2 Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity in Normal and Subcortical Vascular Cognitive Impairment Subjects Unknown status NCT01466543 Phase 2 Zydena (Udenafil);Placebo
3 The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients Unknown status NCT03092804
4 The Effect of Transcranial Direct Current Stimulation on Subcortical Brain Functioning Terminated NCT01602276

Search NIH Clinical Center for Dementia - Subcortical

Genetic Tests for Dementia - Subcortical

Anatomical Context for Dementia - Subcortical

MalaCards organs/tissues related to Dementia - Subcortical:

40
Brain, Testes, Thalamus, Skin, Temporal Lobe, Cortex, Smooth Muscle

Publications for Dementia - Subcortical

Articles related to Dementia - Subcortical:

(show top 50) (show all 422)
# Title Authors PMID Year
1
Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling? 61
32046035 2020
2
Modeling Mixed Vascular and Alzheimer's Dementia Using Focal Subcortical Ischemic Stroke in Human ApoE4-TR:5XFAD Transgenic Mice. 61
32086779 2020
3
Central Nervous System Systemic Lupus Erythematosus (CNS-SLE) Vasculitis Mimicking Lewy Body Dementia: A Case Report Emphasizing the Role of Imaging With an Analysis of 33 Comparable Cases From the Scientific Literature. 61
31996085 2020
4
General anesthesia considerations in CADASIL disease. 61
30665799 2019
5
Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit. 61
31496716 2019
6
History of Subcortical Cognitive Impairment. 61
31220831 2019
7
Secondary dementia due to Lyme neuroborreliosis. 61
30046879 2018
8
Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance, Cortical Atrophy, and Network Measures in a Memory Clinic Population. 61
29843234 2018
9
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment. 61
28567537 2017
10
Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype. 61
28061383 2017
11
FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations. 61
27915581 2017
12
Misidentification Delusions: Prevalence in Different Types of Dementia and Validation of a Structured Questionnaire. 61
26859554 2016
13
Association of Motoric Cognitive Risk Syndrome With Brain Volumes: Results From the GAIT Study. 61
26946101 2016
14
Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders. 61
27455335 2016
15
Cognitive Impairment in Multiple Sclerosis: Clinical Manifestation, Neuroimaging Correlates, and Treatment. 61
27116727 2016
16
[Validation of the Seven Minute Screen for use in a memory clinic]. 61
26860596 2016
17
The phenotypic spectrum of progressive supranuclear palsy. 61
26421392 2016
18
Cadasil - genetic and ultrastructural diagnosis. Case report. 61
29213994 2015
19
[Subcortical ischemic vascular dementia: lesson from hereditary cerebral small vessel disease]. 61
25846589 2015
20
Normative data for the Montreal Cognitive Assessment in an Italian population sample. 61
25380622 2015
21
CADASIL in central Italy: a retrospective clinical and genetic study in 229 patients. 61
25344745 2015
22
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel C82R mutation in the NOTCH3 gene. 61
25096610 2015
23
Current research, diagnosis, and treatment of fragile X-associated tremor/ataxia syndrome. 61
25606360 2014
24
[HIV 1-associated neurocognitive disorder: current epidemiology, pathogenesis, diagnosis and management]. 61
25292163 2014
25
Dementia with Lewy bodies. 61
24963677 2014
26
Advancements in understanding the mechanisms of symptomatic lacunar ischemic stroke: translation of knowledge to prevention strategies. 61
24490992 2014
27
Psychiatric manifestations in cerebrotendinous xanthomatosis. 61
24002088 2013
28
[Current concepts in vascular dementia]. 61
23803634 2013
29
Rivastigmine for vascular cognitive impairment. 61
23728651 2013
30
The applause sign in cortical and cortical-subcortical dementia. 61
23212756 2013
31
Abnormal sensorimotor plasticity in CADASIL correlates with neuropsychological impairment. 61
23308019 2013
32
COGNITIVE DYSFUNCTION IN FMR1 PREMUTATION CARRIERS. 61
25620901 2013
33
Word list and story recall elicit different patterns of memory deficit in patients with Alzheimer's disease, frontotemporal dementia, subcortical ischemic vascular disease, and Lewy body dementia. 61
23792693 2013
34
In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. 61
23012333 2012
35
Rapidly progressive cognitive impairment, ataxia, and myoclonus: an unusual presentation of a dural arteriovenous fistula. 61
21376630 2012
36
Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy. 61
22347799 2012
37
Vascular parkinsonism: what makes it different? 61
22121251 2011
38
[Subcortical vascular dementia: significance in the differential diagnosis of dementia]. 61
22277428 2011
39
Extrapyramidal syndromes in frontotemporal degeneration. 61
21887521 2011
40
[Symptoms of Lewy body dementia and clinical course compared with Alzheimer's disease]. 61
22152910 2011
41
Milestones in Parkinson's disease--clinical and pathologic features. 61
21626546 2011
42
Category cued recall following controlled encoding as a neuropsychological tool in the diagnosis of Alzheimer's disease: a review of the evidence. 61
21086049 2011
43
Retinal nerve fiber layer thinning in CADASIL: an optical coherence tomography and MRI study. 61
21051887 2011
44
Impaired ideomotor limb apraxia in cortical and subcortical dementia: a comparison of Alzheimer's and Huntington's disease. 61
21212634 2011
45
Neuropathology does not Correlate with Regional Differences in the Extent of Expansion of CTG Repeats in the Brain with Myotonic Dystrophy Type 1. 61
21245981 2010
46
Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. 61
20880750 2010
47
Lymhomatosis cerebri--a rare cause of leukoencephalopathy. 61
20304432 2010
48
Sporadic leucodystrophy with neuroaxonal spheroids: persistence of DWI changes and neurocognitive profiles: a case study. 61
20176606 2010
49
Action versus animal naming fluency in subcortical dementia, frontal dementias, and Alzheimer's disease. 61
20104387 2010
50
Sharpening the boundaries of Parkinson-associated dementia: recommendation for a neuropsychological diagnostic procedure. 61
20119649 2010

Variations for Dementia - Subcortical

Expression for Dementia - Subcortical

Search GEO for disease gene expression data for Dementia - Subcortical.

Pathways for Dementia - Subcortical

GO Terms for Dementia - Subcortical

Sources for Dementia - Subcortical

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
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30 HMDB
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32 ICD10
33 ICD10 via Orphanet
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36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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