MCID: DMD001
MIFTS: 23

Demodicidosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Demodicidosis

MalaCards integrated aliases for Demodicidosis:

Name: Demodicidosis 20 58
Infestation by Demodex 70
Demodicosis 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 B88.0
UMLS via Orphanet 71 C3854478
Orphanet 58 ORPHA283
UMLS 70 C0392666

Summaries for Demodicidosis

MalaCards based summary : Demodicidosis, also known as infestation by demodex, is related to rosacea and alopecia. An important gene associated with Demodicidosis is STAT1 (Signal Transducer And Activator Of Transcription 1). The drugs Ivermectin and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and skin.

Wikipedia : 73 Mange /ˈmeɪndʒ/ is a type of skin disease caused by parasitic mites. Because mites also infect plants,... more...

Related Diseases for Demodicidosis

Diseases related to Demodicidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 rosacea 10.5
2 alopecia 10.4
3 pyoderma 10.2
4 leukemia, acute lymphoblastic 10.2
5 acne 10.1
6 hypothyroidism 10.1
7 folliculitis 10.1
8 acquired immunodeficiency syndrome 10.1
9 blepharitis 10.1
10 granulomatous rosacea 10.1
11 mite infestation 10.0
12 cytokine deficiency 10.0
13 graft-versus-host disease 10.0
14 skin disease 10.0
15 keratitis, hereditary 9.9
16 bacterial infectious disease 9.9
17 keratosis 9.9
18 eye disease 9.9
19 conjunctivitis 9.9
20 keratoconjunctivitis 9.9
21 immune deficiency disease 9.8
22 candidiasis, familial, 6 9.8
23 immunodeficiency 31c 9.8
24 exanthem 9.8
25 childhood acute lymphocytic leukemia 9.8
26 pemphigus foliaceus 9.8
27 telangiectasis 9.8
28 blepharoconjunctivitis 9.8
29 basal cell carcinoma 9.8
30 facial dermatosis 9.8
31 scalp dermatosis 9.8
32 tinea favosa 9.8
33 pustulosis of palm and sole 9.8
34 neurofibromatosis 9.8
35 seborrheic dermatitis 9.8
36 psoriasis 9.8
37 pemphigus 9.8
38 otitis externa 9.8
39 meibomian cyst 9.8
40 acute graft versus host disease 9.8
41 grover's disease 9.8
42 hansen's disease 9.8
43 autoimmune disease 9.8
44 ige responsiveness, atopic 9.8
45 dowling-degos disease 1 9.8
46 lymphoma, hodgkin, classic 9.8
47 ataxia and polyneuropathy, adult-onset 9.8
48 autoimmune lymphoproliferative syndrome 9.8
49 dermatitis, atopic 9.8
50 langerhans cell histiocytosis 9.8

Graphical network of the top 20 diseases related to Demodicidosis:



Diseases related to Demodicidosis

Symptoms & Phenotypes for Demodicidosis

Drugs & Therapeutics for Demodicidosis

Drugs for Demodicidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3 70288-86-7 6474909
2 Antiparasitic Agents Phase 3
3 Anti-Infective Agents
4 Tea Tree
5 Tea
6 Anti-Infective Agents, Local
7
Tea tree oil Experimental, Nutraceutical 68647-73-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 a Randomised, Double Blind, Placebo Controlled, Half- Face Study to Evaluate the Effect of Topical Ivermectin Cream 0.5% on Demodicidosis Unknown status NCT02036229 Phase 3 ivermectin cream 0.5%
2 Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Evaporated Dry Eye With Demodicosis Completed NCT04165785
3 Clinical Correlation Between Facial Demodicosis and Ocular Demodicosis Recruiting NCT04377841
4 Treatment of Ocular Demodicosis by Cleansing the Eyelid Margins Combined With Tea Tree Oil Ointment Recruiting NCT04451122

Search NIH Clinical Center for Demodicidosis

Genetic Tests for Demodicidosis

Anatomical Context for Demodicidosis

MalaCards organs/tissues related to Demodicidosis:

40
Eye, Skin

Publications for Demodicidosis

Articles related to Demodicidosis:

(show top 50) (show all 119)
# Title Authors PMID Year
1
Increased Demodex Density in Patients Hospitalized for Worsening Heart Failure. 61
32413980 2020
2
Palpebral and facial skin infestation by Demodex folliculorum. 61
31563449 2020
3
Pre-Treatment and Post-Treatment Demodex Densities in Patients under Immunosuppressive Treatments. 61
32138191 2020
4
The sensitivity of Demodex canis (Acari: Demodicidae) to the essential oil of Melaleuca alternifolia - an in vitro study. 61
32935769 2020
5
Treatment of Demodex-associated inflammatory skin conditions: A systematic review. 61
31583801 2019
6
Demodicidosis of the nipple. 61
30587280 2019
7
Demodicidosis Accompanying Acute Cutaneous Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation 61
29983401 2018
8
Rosacea and demodicidosis associated with gain-of-function mutation in STAT1. 61
28622416 2017
9
High prevalence of Demodex spp. infestation among patients with posterior blepharitis: correlation with age and cylindrical dandruff. 61
28552438 2017
10
Prevalence and Density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Erzincan Province. 61
28695830 2017
11
Usefulness of dermoscopy in the diagnosis and monitoring treatment of demodicidosis. 61
28243492 2017
12
Dermoscopy in General Dermatology: A Practical Overview. 61
27613297 2016
13
Skin scrapings versus standardized skin surface biopsy to detect Demodex mites in patients with facial erythema of uncertain cause - a comparative study. 61
26858058 2016
14
Clues to Facial Demodicidosis: A Case Illustration. 61
27512199 2016
15
Unilateral Demodicidosis of Face Mimicking Hansens Disease. 61
28326184 2016
16
Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications. 61
26954318 2016
17
The practical usefulness of dermoscopy in general dermatology. 61
26086412 2015
18
Chronic lymphocytic lymphoma presenting with recurrent demodicidosis. 61
25707323 2015
19
Hypothesis of demodicidosis rosacea flushing etiopathogenesis. 61
25683389 2015
20
[Demodex spp in chronic blepharitis patients]. 61
25860042 2015
21
Demodicidosis on the arms of a patient with pemphigus foliaceus. 61
25128143 2014
22
Ocular demodicidosis as a risk factor of adult recurrent chalazion. 61
23873491 2014
23
Human demodex mite: the versatile mite of dermatological importance. 61
24470662 2014
24
Crusted demodicosis in an immunocompetent pediatric patient. 61
25371830 2014
25
Demodicidosis: an uncommon erythema after cranio-maxillofacial surgery. 61
23099109 2013
26
Phylogenetic analysis of Demodex caprae based on mitochondrial 16S rDNA sequence. 61
23996126 2013
27
[Measurement of the index of infection by Demodex spp in patients with chronic blepharitis and in patients without other ocular diseases]. 61
24248163 2013
28
Demodicidosis associated with psoriasis therapy--two case reports. 61
23905976 2013
29
Method to identify Demodex in the eyelash follicle without epilation. 61
23670124 2013
30
Differential diagnosis of facial acne on black skin. 61
23210948 2012
31
Demodicidosis simulating acute graft-versus-host disease after allogeneic stem cell transplantation in one patient with acute lymphoblastic leukemia. 61
22487272 2012
32
[Efficacy of diuretics in the treatment of Morbihan's disease: three cases]. 61
22963967 2012
33
Facial demodicidosis: a diagnostic challenge. 61
22470219 2012
34
Diseases of the male nipple and areola. 61
21651722 2011
35
Crusted rosacea-like demodicidosis in an HIV-positive female. 61
21920237 2011
36
Tablets based on compressed zein microspheres for sustained oral administration: design, pharmacokinetics, and clinical study. 61
20418265 2011
37
[Rosacea-like demodicidosis and chronic blepharitis]. 61
21276458 2011
38
[Human demodicidosis in Sfax area (Tunisia)]. 61
20596809 2010
39
Dermoscopy as a diagnostic tool in demodicidosis. 61
20931672 2010
40
Skin lesions associated with Demodex sp. in a llama (Lama glama). [corrected] 61
20722277 2010
41
[Spinulosis as a manifestation of demodicidosis]. 61
19709560 2009
42
Otitis externa and myringitis due to demodicidosis. 61
19588062 2009
43
Demodicidosis as a cause of facial eruption developing early after allogeneic hematopoietic stem cell transplantation. 61
18783387 2008
44
Rosacea-like demodicidosis. 61
19022195 2008
45
Clinical importance of Demodex folliculorum in patients receiving phototherapy. 61
18173609 2008
46
Pimecrolimus-induced rosacea-like demodicidosis. 61
17910727 2007
47
Granulomatous rosacea-like demodicidosis. 61
18319006 2007
48
Recalcitrant papulopustular rosacea in an immunocompetent patient responding to combination therapy with oral ivermectin and topical permethrin. 61
17944176 2007
49
Scalp demodicidosis mimicking favus in a 6-year-old boy. 61
17637363 2007
50
Demodicidosis as spinulosis of the face: a therapeutic challenge. 61
17243980 2007

Variations for Demodicidosis

Expression for Demodicidosis

Search GEO for disease gene expression data for Demodicidosis.

Pathways for Demodicidosis

GO Terms for Demodicidosis

Sources for Demodicidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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