Demyelinating Polyneuropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DMY001 MIFTS: 41	Demyelinating Polyneuropathy Categories: Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Demyelinating Polyneuropathy

MalaCards integrated aliases for Demyelinating Polyneuropathy:

Name: Demyelinating Polyneuropathy ¹² ¹⁵

Peripheral Demyelinating Neuropathy ¹² ⁷¹

Demyelinating Peripheral Neuropathy ⁶

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5214

NCIt ⁵⁰ C27062

SNOMED-CT ⁶⁷ 23414001

UMLS ⁷¹ C0270922

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Summaries for Demyelinating Polyneuropathy

MalaCards based summary : Demyelinating Polyneuropathy, also known as peripheral demyelinating neuropathy, is related to guillain-barre syndrome and polyneuropathy. An important gene associated with Demyelinating Polyneuropathy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Spinal Cord Injury and Cell adhesion molecules. The drugs gamma-Globulins and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

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Related Diseases for Demyelinating Polyneuropathy

Diseases in the Demyelinating Polyneuropathy family:

Subacute Inflammatory Demyelinating Polyneuropathy	Acute and Subacute Inflammatory Demyelinating Polyneuropathy
Chronic Acquired Demyelinating Polyneuropathy

Diseases related to Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)

#	Related Disease	Score	Top Affiliating Genes
1	guillain-barre syndrome	32.6	PMP22 HP ALB
2	polyneuropathy	31.3	TTR PMP22 NGF NFASC MAG IFNA2
3	multifocal motor neuropathy	31.2	FCGR2B CNTN2
4	neuropathy	31.2	TTR PMP22 NGF NFASC MAG ALB
5	sensory peripheral neuropathy	31.2	PMP22 NGF MAG
6	chronic polyneuropathy	30.9	MAG FCGR2B
7	polyradiculopathy	30.7	NFASC CNTN1
8	demyelinating disease	30.7	PMP22 NGF MMP9 MAG
9	autoimmune neuropathy	30.6	NFASC MAG FCGR2B CNTN1
10	miller fisher syndrome	30.6	NFASC MAG CNTN1 ALB
11	mononeuropathy	30.6	TTR PMP22 NGF MAG ALB
12	peripheral nervous system disease	30.5	TTR PMP22 NGF NFASC MMP9 MAG
13	nerve compression syndrome	30.4	TTR PMP22 NGF ALB
14	median neuropathy	30.4	TTR PMP22
15	autoimmune disease	30.2	TNFSF13B MMP9 FCGR2B CD1D AIRE
16	autonomic neuropathy	30.1	TTR NGF ALB
17	meningoencephalitis	30.1	NGF CLDN5 ALB
18	autoimmune peripheral neuropathy	30.1	MAG AIRE
19	corneal disease	30.0	NGF MMP9 ALB
20	central nervous system disease	29.9	TTR NGF MMP9 ALB
21	thrombocytopenia	29.7	TNFSF13B MMP9 IFNA2 HP FCGR2B ALB
22	chronic kidney disease	29.6	TTR PTGDS MMP9 HP ALB
23	malaria	29.4	TNFSF13B MMP9 HP FCGR2B ALB AIF1
24	multiple sclerosis	28.8	TNFSF13B PTGDS NGF MMP9 MAG CD52
25	peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	11.9
26	chronic inflammatory demyelinating polyradiculoneuropathy	11.9
27	guillain-barre syndrome, familial	11.6
28	neurodevelopmental disorder with central and peripheral motor dysfunction	11.3
29	chronic acquired demyelinating polyneuropathy	11.2
30	subacute inflammatory demyelinating polyneuropathy	11.2
31	lewis-sumner syndrome	11.1
32	acute and subacute inflammatory demyelinating polyneuropathy	11.1
33	charcot-marie-tooth disease and deafness	11.1
34	marinesco-sjogren syndrome	11.1
35	charcot-marie-tooth disease, type 4k	11.1
36	neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities	11.1
37	mannosidosis, beta a, lysosomal	11.1
38	canomad syndrome	11.1
39	polyradiculoneuropathy	10.7
40	ataxia and polyneuropathy, adult-onset	10.5
41	respiratory failure	10.5
42	charcot-marie-tooth disease	10.5
43	axonal neuropathy	10.5
44	tooth disease	10.4
45	hereditary neuropathies	10.4
46	myasthenia gravis	10.4
47	quadriplegia	10.4
48	poems syndrome	10.4
49	tremor	10.4
50	lesion of sciatic nerve	10.4	PMP22 NGF

Graphical network of the top 20 diseases related to Demyelinating Polyneuropathy:

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Symptoms & Phenotypes for Demyelinating Polyneuropathy

MGI Mouse Phenotypes related to Demyelinating Polyneuropathy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.15	AIRE CD1D CNTN1 CNTN2 FCGR2B GAS6
2	homeostasis/metabolism	MP:0005376	10.1	AIF1 AIRE ALB CD1D FCGR2B GAS6
3	cardiovascular system	MP:0005385	10.02	AIF1 ALB CD1D CLDN5 FCGR2B GAS6
4	immune system	MP:0005387	9.9	AIF1 AIRE ALB CD1D FCGR2B GAS6
5	mortality/aging	MP:0010768	9.77	AIRE ALB CD1D CLDN5 CNTN1 FCGR2B
6	nervous system	MP:0003631	9.44	AIF1 AIRE CD1D CLDN5 CNTN1 CNTN2

Sources

Drugs & Therapeutics for Demyelinating Polyneuropathy

Drugs for Demyelinating Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

gamma-Globulins

Phase 4

Rho(D) Immune Globulin

Phase 4

Prednisone

Approved, Vet_approved

Phase 3

53-03-2

5865

Synonyms:

(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione

.delta. E

.delta.(sup1)-Cortisone

.delta.1-Cortisone

.delta.1-Dehydrocortisone

.delta.-Cortelan

.delta.-Cortisone

.delta.-Cortone

.delta.-E

.delta.sone

1,2-Dehydrocortisone

1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

1-Cortisone

1-Dehydrocortisone

53-03-2

68-59-7

81552_FLUKA

AC-11112

AC1L1LB2

AC1Q29EZ

Acis brand OF prednisone

ACon0_000082

ACon1_000297

Acsis, prednison

Adasone

AI3-52939

Ancortone

Apo-prednisone

Apo-Prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Bio-0649

BPBio1_000323

BRD-K85883481-001-04-2

BSPBio_000293

C07370

C21H26O5

Cartancyl

CCRIS 2646

CHEBI:8382

CHEMBL635

CID5865

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

CPD001227202

Cutason

Dacorten

Dacortin

DB00635

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

delta cortelan

Delta Cortelan

Delta E

Delta E.

delta(sup 1)-Cortisone

delta(sup 1)-Dehydrocortisone

delta-1-Cortisone

delta-1-Dehydrocortisone

Delta-cortelan

Delta-Cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Delta-cortisone

delta-Cortone

Deltacortone

Delta-cortone

Delta-dome

Delta-Dome

Deltasone

Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

EINECS 200-160-3

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

Fernisone

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

HMS1568O15

HMS2090J13

Hoechst brand OF prednisone

Hostacortin

HSDB 3168

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Liquid Pred

Lisacort

LMST02030180

Lodotra

LS-1325

MEGxm0_000443

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Meticorten (Veterinary)

Metrevet (Veterinary)

Mibe brand OF prednisone

MLS001061265

MLS001304073

MLS001335907

MLS001335908

MLS002154191

MLS002207083

MolPort-001-740-041

NCGC00090766-01

NCGC00090766-02

NCGC00090766-03

NCI60_000008

NCI-C04897

Nisona

Nizon

Novoprednisone

NSC 10023

NSC10023

Nurison

Orasone

Origen Prednisone

P1276

P6254_SIGMA

Panafcort

Panasol

Paracort

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

Predni tablinen

Prednicen-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

Prednisone [INN:BAN]

Prednisone Intensol

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Prestwick_405

Prestwick0_000077

Prestwick1_000077

Prestwick2_000077

Prestwick3_000077

Pronison

Pronisone

Rectodelt

Retrocortine

S1622_Selleck

SAM002264641

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

Servisone

SK-Prednisone

SMR000718760

SMR001227202

Solvay brand OF prednisone

Sone

SPBio_002214

Sterapred

Supercortil

Trommsdorff brand OF prednisone

U 6020

Ultracorten

Ultracortene

UNII-VB0R961HZT

Winpred

WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ

Wojtab

Zenadrid

Zenadrid (veterinary)

Zenadrid [veterinary]

ZINC03875357

Glycine

Approved, Nutraceutical, Vet_approved

Phase 3

56-40-6

750

Synonyms:

(1-13c)glycinato

(15N)Glycine

15527_RIEDEL

15527_SIAL

15743-44-9 (mono-potassium salt)

17829-66-2 (cobalt salt)

18875-39-3

2,2-dialkylglycines

2311-65-1

25718-94-9

29728-27-6 (monoammonium salt)

2-Aminoacetate

2-Aminoacetic acid

32817-15-5 (copper salt)

33226_RIEDEL

33226_SIAL

33242-26-1 (calcium salt)

35947-07-0 (calcium salt (2:1))

410225_SIAL

50046_FLUKA

50046_SIGMA

513-29-1 (sulfate (3:1))

52955-63-2

56-40-6

57678-19-0

6000-43-7 (hydrochloride)

6000-44-8 (mono-hydrochloride salt)

63183-41-5 (hydrochloride hydrogen carbonate)

71295-98-2 (phosphate (1:1))

7490-95-1 (hydrochloride (2:1)

7490-95-1 (hydrochloride (2:1))

7575-55-5

848646-45-7

87867-94-5

AB1002628

AB-131/40217813

AC1L19XW

AC1Q28JW

AC1Q53O0

Acid, aminoacetic

Acide aminoacetique

Acide aminoacetique [INN-French]

Acido aminoacetico

Acido aminoacetico [INN-Spanish]

Acidum aminoaceticum

Acidum aminoaceticum [INN-Latin]

Aciport

AI3-04085

AKOS000119626

Aminoacetate

Amino-acetate

aminoacetic acid

Aminoacetic acid

Amino-acetic acid

AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER

Aminoazijnzuur

Aminoessigsaeure

Aminoessigsäure

Aminoethanoate

Aminoethanoic acid

Amitone

an alpha amino acid ester

AR-1A0345

AR-1A0532

B72BA06C-60E9-4A83-A24A-A2D7F465BB65

Biomol-NT_000195

bmse000089

BPBio1_001222

C00037

Calcium salt glycine

CCRIS 5915

CHEBI:15428

CHEBI:15705

CHEBI:16228

CHEMBL773

CID750

Cobalt salt glycine

Copper salt glycine

Corilin

CPD-8569

D00011

DB00145

EINECS 200-272-2

FEMA No. 3287

FT-0083159

G0099

G0317

G5417_SIGMA

G5523_SIGMA

G7126_SIGMA

G7403_SIGMA

G8790_SIGMA

G8898_SIGMA

Glicina

Glicina [INN-Spanish]

Glicoamin

gly

Gly

GLY (IUPAC abbrev)

Glycin

glycine

Glycine

Glycine (JP15/USP)

Glycine [INN]

GLYCINE 1.5% IN PLASTIC CONTAINER

Glycine carbonate (1:1), monosodium salt

Glycine carbonate (2:1), monolithium salt

Glycine carbonate (2:1), monopotassium salt

Glycine carbonate (2:1), monosodium salt

Glycine hydrochloride

Glycine hydrochloride (2:1)

Glycine iron sulphate (1:1)

Glycine phosphate

Glycine phosphate (1:1)

Glycine sulfate (3:1)

GLYCINE, ACS

Glycine, calcium salt

Glycine, calcium salt (2:1)

Glycine, cobalt salt

Glycine, copper salt

Glycine, homopolymer (VAN)

Glycine, labeled with carbon-14

Glycine, monoammonium salt

Glycine, monopotasssium salt

Glycine, monosodium salt

Glycine, non-medical

Glycine, sodium hydrogen carbonate

Glycine-UL-14C hydrochloride

Glycinum

Glycinum [INN-Latin]

Glycocoll

Glycolixir

Glycosthene

Glykokoll

Glyzin

Gyn-hydralin

H2N-CH2-COOH

Hampshire glycine

Hgly

H-Gly-OH

HSDB 495

Hydrochloride, glycine

InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5

KST-1A2919

KST-1A8102

L001246

L-alpha-amino acids

Leimzucker

L-Glycine

LS-218

MolPort-000-871-607

Monoammonium salt glycine

Monopotasssium salt glycine

Monosodium salt glycine

NCGC00024503-01

NCGC00024503-02

nchem.554-comp2

nchembio.121-comp9

nchembio.145-comp33

nchembio.198-comp12

NChemBio.2007.13-comp1

nchembio.265-comp9

nchembio.266-comp30

NSC 25936

NSC25936

P8791_SIGMA

Padil

Phosphate, glycine

polyglycine

Polyglycine II

S04-0135

Salt glycine, monoammonium

Salt glycine, monosodium

Sucre de gelatine

Tocris-0219

UNII-TE7660XO1C

W328707_ALDRICH

WLN: Z1VQ

Anti-Inflammatory Agents

Phase 3

glucocorticoids

Phase 3

Antineoplastic Agents, Hormonal

Phase 3

rituximab

Approved

Phase 2

174722-31-7

10201696

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Synonyms:

(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

01769_FLUKA

2d0k

33609-88-0

36653-55-1 (mono-potassium salt)

59-30-3

6484-89-5 (mono-hydrochloride salt)

AC-11682

AC1L1LNX

Acfol (Spain)

Acide folique

Acide folique [INN-French]

Acido folico

ácido fólico

Acido folico [INN-Spanish]

Acidum folicum

Acidum folicum [INN-Latin]

Acifolic

AI3-26387

AKOS000503224

Antianemia factor

Apo-Folic

ARONIS014410

b9, Vitamin

BIDD:ER0563

BIDD:GT0641

BIF0608

bmse000299

BPBio1_000654

BSPBio_000594

BSPBio_002338

C00504

C20H20N6O6

CAS-59-30-3

CCRIS 666

CHEBI:27470

CHEMBL1622

CID6037

CPD000471860

Cytofol

D00070

DB00158

DivK1c_000494

Dosfolat b activ

Dosfolat B activ

EINECS 200-419-0

F0043

F7876_SIAL

F7876_SIGMA

F8758_SIGMA

F8798_SIAL

F8890_SIGMA

Facid

Factor U

FOL

Folacid

Folacin

Folaemin

Folaemin [Netherlands]

Folan

Folasic (Australia)

Folate

Folbal

Folcidin

Folcidin (VAN)

Folcysteine

Foldine

Foldine [France]

Folettes

Foliamin

Folic

folic acid

Folic acid

Folic acid (JP15/USP/INN)

Folic acid (TN)

Folic acid [BAN:INN:JAN]

Folic acid [INN:BAN:JAN]

Folic acid dihydrate

Folic acid, (D)-isomer

Folic acid, (DL)-isomer

Folic acid, calcium salt (1:1)

Folic acid, monopotassium salt

Folic acid, monosodium salt

Folic acid, potassium salt

Folic acid, sodium salt

Folicet

Folicet (TN)

Folico

Folico (Italy)

Folina

Folina (Italy)

Folipac

Folsaeure

Folsan

Folsaure

Folsäure

Folsav

Folvite

Folvron

Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L

HMS1921D20

HMS2092N17

HMS501I16

HSDB 2002

IDI1_000494

Incafolic

InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s

KBio1_000494

KBio2_001861

KBio2_004429

KBio2_006997

KBio3_001558

KBioGR_002222

KBioSS_001861

Kyselina listova

Kyselina listova [Czech]

Liver lactobacillus casei factor

Liver Lactobacillus casei factor

LS-2157

Millafol

Mission prenatal

Mittafol

MLS001304016

MLS001335861

MolPort-004-285-551

N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid

N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid

N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

NCGC00016265-01

NCGC00142391-01

nchembio.108-comp10

Nifolin

Nifolin [Denmark]

NINDS_000494

Novofolacid

Novofolacid [Canada]

N-Pteroyl-L-glutamate

N-pteroyl-L-glutamic acid

N-Pteroyl-L-glutamic acid

NSC 3073

PGA

PGA (VAN)

Prestwick_230

Prestwick3_000627

PteGlu

Pteroylglutamate

Pteroylglutamic acid

Pteroyl-L-glutamate

Pteroyl-L-glutamic acid

Pteroyl-L-monoglutamate

Pteroyl-L-monoglutamic acid

Pteroylmonoglutamate

Pteroylmonoglutamic acid

SAM002264616

SDCCGMLS-0066738.P001

Serum Folate Level

SMP2_000137

SMR000471860

SPBio_001357

Spectrum_001381

SPECTRUM1502020

Spectrum2_001459

Spectrum3_000749

Spectrum4_001751

Spectrum5_000602

UNII-935E97BOY8

Usaf cb-13

Vitamin B11

Vitamin b9

Vitamin B9

Vitamin Bc

Vitamin BC

Vitamin be

Vitamin Be

Vitamin m

Vitamin M

Biotin

Approved, Investigational, Nutraceutical

Phase 2

58-85-5

171548

Synonyms:

(+)-Biotin

-(+)-Biotin

(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valerate

(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid

(3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valerate

(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid

(3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid

1SWK

1SWN

1SWR

5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoate

5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid

5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoic acid

Biocur brand OF biotin

Biodermatin

Bioepiderm

Biokur

Bios H

Bios II

Biotin

Biotin biocur brand

Biotin dermapharm brand

Biotin gelfert

Biotin hermes

Biotin hermes brand

Biotin medopharm brand

Biotin ratiopharm

Biotin ratiopharm brand

Biotin roche brand

Biotin simons brand

Biotin strathmann brand

Biotin ziethen brand

Biotina

Biotine

Biotine roche

Biotinratiopharm

Biotin-ratiopharm

Biotinum

cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valerate

cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid

cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valerate

cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid

cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valerate

cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid

cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valeric acid

Coenzyme R

D-(+)-biotin

D(+)-Biotin

D-(+)-Biotin

D-Biotin

D-Biotin factor S

Deacura

delta-(+)-Biotin

delta-Biotin

delta-Biotin factor S

Dermapharm brand OF biotin

E+b pharma brand OF biotin

Factor S

Factor S (vitamin)

Gabunat

Gelfert, biotin

H, Vitamin

Hermes brand OF biotin

Hermes, biotin

Hexahydro-2-oxo-[3as-(3aa,4b,6aa)]-1H-thieno[3,4-D]imidazole-4-pentanoate

Hexahydro-2-oxo-[3as-(3aa,4b,6aa)]-1H-thieno[3,4-D]imidazole-4-pentanoic acid

Hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-thieno[3,4-D]imidazole-4-pentanoate

Hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-thieno[3,4-D]imidazole-4-pentanoic acid

Hexahydro-2-oxo-1H-thieno(3,4-D)imidazole-4-pentanoate

Hexahydro-2-oxo-1H-thieno(3,4-D)imidazole-4-pentanoic acid

Lutavit H2

Medea brand OF biotin sodium salt

Medebiotin

Medobiotin

Medopharm brand OF biotin

Meribin

Ratiopharm brand OF biotin

Roche brand OF biotin

Roche, biotine

Rombellin

Rovimix H 2

Simons brand OF biotin

Strathmann brand OF biotin

Vitamin b7

Vitamin B7

Vitamin H

Vitamin-H

Ziethen brand OF biotin

Thymoglobulin

Phase 2

Trace Elements

Phase 2

Micronutrients

Phase 2

Vitamin B Complex

Phase 2

Vitamin B7

Phase 2

Vitamins

Phase 2

Folate

Phase 2

Vitamin B9

Phase 2

Nutrients

Phase 2

Protective Agents

Phase 2

Antioxidants

Phase 2

Alpha-lipoic Acid

Phase 2

Thioctic Acid

Phase 2

Immunoglobulins

Phase 2

Immunologic Factors

Phase 2

Immunoglobulins, Intravenous

Phase 2

Antibodies

Phase 2

Immunoglobulin G

Phase 2

Autoantibodies

Phase 2

Pharmaceutical Solutions

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Complement System Proteins

Phase 2

Antibodies, Monoclonal

Phase 2

Antibodies, Anti-Idiotypic

Interventional clinical trials:

(show all 34)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized, Parallel Study of Subcutaneous Versus Intravenous Immunoglobulin in Treatment-naïve Patients With Chronic Inflammatory Demyelinating Polyneuropathy	Recruiting	NCT04589299	Phase 4
2	Randomized Study of Single vs. Multiple Privigen Dose Regimens in Pediatric CIDP	Recruiting	NCT03684018	Phase 4
3	Prospective, Open-Label, Phase IIIb Study Evaluating the Safety, Tolerability and Efficacy of Panzyga® in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Administered at Standard and High Infusion Rates	Unknown status	NCT03166527	Phase 3	Immune Globulin 10% Intravenous Solution
4	Multicentre Randomized Open-label Trial to Compare Efficacy and Tolerance of Corticosteroids and IVIg in Patients With Chronic Inflammatory Demyelinating Polyneuropathy on a One Year Follow up	Completed	NCT01349270	Phase 3	Immunoglobulin perfusion;Prednisone
5	Multicenter, Open-label Extension Study to Investigate the Long-term Safety and Efficacy of IgPro20 in Maintenance Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) in Subjects Completing Study IgPro20_3003	Completed	NCT02027701	Phase 3
6	A Single-arm Study to Demonstrate the Efficacy and Safety of Privigen in the Treatment of Subjects With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)	Completed	NCT01184846	Phase 3
7	NPB-01(Intravenous Immunoglobulin) Maintenance Therapy for Patients With Chronic Inflammatory Demyelinating Polyneuropathy.	Completed	NCT01824251	Phase 3	NPB-01
8	Randomized, Multicenter, Double-blind, Placebo-controlled, Parallel-group Phase III Study to Investigate the Efficacy, Safety, and Tolerability of 2 Different Doses of IgPro20 (Subcutaneous Immunoglobulin) for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - the PATH Study	Completed	NCT01545076	Phase 3
9	Multicenter, Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of IGIV-Chromatography (IGIV-C), 10% Treatment in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy	Completed	NCT00220740	Phase 3	Immune Globulin IV (Human), 10% Caprylate/Chromatography Purified;Albumin (Human) 25%, United States Pharmacopeia (USP)
10	Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy	Completed	NCT00004772	Phase 3	Immune globulin
11	Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy	Completed	NCT00004939	Phase 3	,4-diaminopyridine
12	Non-myeloablative Autologous Hematopoietic Stem Cell Transplantation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Phase II Trial	Completed	NCT00278629	Phase 2
13	SERENDEM Study: MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study	Completed	NCT02967679	Phase 2	MD1003
14	The Efficacy of High-Dose Intravenous Immunoglobulin in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)	Completed	NCT00001287	Phase 2	intravenous immunoglobulin (IVIg)
15	Lipoic Acid for Chronic Inflammatory Demyelinating Polyneuropathy-A Randomized, Double-Blind, Placebo Controlled Pilot Study	Completed	NCT00962429	Phase 2	lipoic acid
16	A Phase 2 Trial to Investigate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 SC in Adult Patients With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)	Recruiting	NCT04281472	Phase 2
17	Open-label Extension of the ARGX-113-1802 Trial to Investigate the Long-term Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Patients With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)	Recruiting	NCT04280718	Phase 2
18	The Evaluation of Efficacy and Safety of Rituximab (Genetical Recombination) in Refractory Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patients With Immunoglobulin G4 (IgG4) Autoantibodies in the Exploratory Clinical Trial	Active, not recruiting	NCT03864185	Phase 2
19	Rituximab in Chronic Inflammatory Demyelinating Polyneuropathy: A Phase II Study	Not yet recruiting	NCT04480450	Phase 2	Rituximab
20	A Phase 2, Multicenter, Open-label, Proof-of-concept Study Evaluating the Efficacy, Safety, and Tolerability of BIVV020 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)	Not yet recruiting	NCT04658472	Phase 2	BIVV020
21	A Phase II Trial of High-dose Cyclophosphamide for Moderate to Severe Refractory Chronic Inflammatory Demyelinating Polyneuropathy	Withdrawn	NCT01236456	Phase 2	Cyclophosphamide
22	Pilot Study of Acthar® Gel in Chronic Inflammatory Demyelinating Neuropathy	Withdrawn	NCT02574962	Phase 2	H.P. Acthar® Gel
23	A Study of Subcutaneous Immunoglobulin as Chronic Treatment for Patients With Chronic Inflammatory Demyelinating Polyneuropathy	Unknown status	NCT02465359		Immune Globulin Subcutaneous (Human)
24	Quantification of Nerve Stiffness in Patients With Peripheral Neuropathies	Unknown status	NCT03397303
25	sCD163 & CD19 as Candidate Biomarkers in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - A Study of sCD163 in the Cerebrospinal Fluid	Unknown status	NCT02271724
26	Effect of Resistance and Aerobic Exercise on Muscle Strength, Aerobic Capacity and Quality of Life in Patients Treated With Immunoglobulin for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) or Multifocal Motor Neuropathy (MMN)	Completed	NCT02121678
27	The Influence of Immunoglobulin Dosage and Administration on Development of Hemolytic Anemia and Variation on Muscle Strength in Patients With CIDP and MMN	Completed	NCT02111590		Immunoglobulins
28	Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy	Completed	NCT01379833
29	Intravenous Immunoglobulin (IVIg) Treatment-Related Fluctuations in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patients Using Daily Grip Strength Measurements (GRIPPER)	Completed	NCT02414490		Intravenous Immunoglobulin
30	Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuropathy With Antibody A MAG	Recruiting	NCT03008733
31	A Registered Cohort Study of Immune-Mediated Neuropathies	Active, not recruiting	NCT04292834
32	Hizentra® in Inflammatory Neuropathies - pHeNIx Study	Not yet recruiting	NCT04672733
33	Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)	Not yet recruiting	NCT03772717		Standard of Care
34	A Multicenter Pilot Study to Determine Criteria for Evaluating the Effectiveness of Two Comparative Monitoring Methods in the Management of Patients With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Receiving Home-based Treatment With IVIg (Privigen®)	Terminated	NCT03779828

Search NIH Clinical Center for Demyelinating Polyneuropathy

Sources

Genetic Tests for Demyelinating Polyneuropathy

Sources

Anatomical Context for Demyelinating Polyneuropathy

MalaCards organs/tissues related to Demyelinating Polyneuropathy:

⁴⁰

T Cells, Bone Marrow, Spinal Cord, Endothelial, Skin, B Cells, Lymph Node

Sources

Publications for Demyelinating Polyneuropathy

Articles related to Demyelinating Polyneuropathy:

(show top 50) (show all 2472)

#	Title	Authors	PMID	Year
1	Antiglycolipid antibodies in Guillain-Barré and Fisher syndromes: discovery, current status and future perspective. ⁶¹	Kusunoki S...Jacobs BC	33376111	2021
2	CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach. ⁶¹	Moritz CP...Antoine JC	33408168	2021
3	Plasma neurofilament light chain as a potential biomarker in Charcot-Marie-Tooth disease. ⁶¹	Millere E...Kenina V	33340200	2021
4	X-linked adrenoleukodystrophy caused by a novel mutation presenting with various phenotypes in a Taiwanese family. ⁶¹	Chien CY...Chen CM	33359056	2021
5	Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy. ⁶¹	Nakamura T...Suzuki Y	33078247	2021
6	Focal Sensory Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). ⁶¹	Shouman K...Dyck PJB	33594681	2021
7	Association between chronic inflammatory demyelinating polyneuropathy and gastrointestinal malignancies. ⁶¹	Malik A...Tabibian JH	33146871	2021
8	Chronic inflammatory demyelinating polyneuropathy and pregnancy: systematic review. ⁶¹	Kohle F...Lehmann HC	33563801	2021
9	Correction to: A Global Survey of Disease Burden in Patients Who Carry a Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy. ⁶¹	Allen JA...Haudrich A	33439475	2021
10	Genetic neuropathies presenting with CIDP-like features in childhood. ⁶¹	Fernandez-Garcia MA...Jungbluth H	33386210	2021
11	Impact of psychiatric distress and physical disability on quality of life in neuromyelitis optica spectrum disorder and chronic autoimmune demyelinating polyneuropathies. ⁶¹	Yalachkov Y...Gehrig J	33383364	2021
12	[Pronounced proximally accentuated changes in high-voltage stimulation and nerve ultrasound in long-standing therapy-naive CIDP variants]. ⁶¹	Gardill K...Schupbach M	33112965	2021
13	Complication of Hepatitis A Infection: Case Report of Acute Inflammatory Demyelinating Polyneuropathy. ⁶¹	Laursen D...Wolford R	33560967	2021
14	Acute Demyelinating Polyneuropathy in a Child with Dengue Shock Syndrome. ⁶¹	Kumar S...Angurana SK	32542487	2021
15	COVID-19-induced exacerbation of chronic inflammatory demyelinating polyneuropathy. ⁶¹	Van Looy E...De Cauwer H	33606069	2021
16	Semi-Automatic MRI Muscle Volumetry to Diagnose and Monitor Hereditary and Acquired Polyneuropathies. ⁶¹	Bahr FS...Dohrn MF	33562055	2021
17	Magnetic resonance neurography in diagnosing childhood chronic inflammatory demyelinating polyradiculoneuropathy. ⁶¹	Yoshii S...Fujii K	33433331	2021
18	Elevated cerebrospinal fluid levels of beta-2-microglobulin in patients with Guillain-Barré syndrome and their correlations with clinical features. ⁶¹	Liu MQ...Yang L	33598798	2021
19	Juvenile Chronic Inflammatory Demyelinating Polyneuropathy Epidemiology in Sardinia, Insular Italy. ⁶¹	Sotgiu S...Nobile-Orazio E	33111308	2021
20	Four mutations in MITF, SOX10 and PAX3 genes were identified as genetic causes of waardenburg syndrome in four unrelated Iranian patients: case report. ⁶¹	Zardadi S...Morovvati S	33557787	2021
21	Successful Nucleoside Analog and Corticosteroid Therapy for Chronic Inflammatory Demyelinating Polyneuropathy in a Patient With Hepatitis B Virus Liver Cirrhosis. ⁶¹	Nugraha ES...Bestari MB	33457438	2021
22	Increased muscle echointensity correlates with clinical disability and muscle strength in chronic inflammatory demyelinating polyneuropathy. ⁶¹	Fisse AL...Pitarokoili K	33404183	2021
23	Application of CMAP scan for the evaluation of patients with chronic inflammatory demyelinating polyneuropathy: a prospective study. ⁶¹	Okhovat AA...Fatehi F	33423829	2021
24	Early axonal loss predicts long-term disability in chronic inflammatory demyelinating polyneuropathy. ⁶¹	Al-Zuhairy A...Krarup C	33581994	2021
25	Psychometric longitudinal evaluation of the Chronic Acquired Polyneuropathy Patient-Reported Index (CAPPRI) in patients with chronic inflammatory demyelinating polyneuropathy. ⁶¹	Sadjadi R...Basta I	33043466	2021
26	Electrophysiological testing in chronic inflammatory demyelinating polyneuropathy patients treated with subcutaneous immunoglobulin: The Polyneuropathy And Treatment with Hizentra (PATH) study. ⁶¹	Bril V...Mielke O	33039291	2021
27	A Global Survey of Disease Burden in Patients Who Carry a Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy. ⁶¹	Allen JA...Haudrich A	33113101	2021
28	Changes in motor nerve excitability in acute phase Guillain-Barré syndrome. ⁶¹	Drenthen J...Jacobs BC	33452679	2021
29	Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis. ⁶¹	Koike H...Katsuno M	33540321	2021
30	Proper definition of the set of autoantibody-targeted antigens relies on appropriate reference group selection. ⁶¹	Moritz CP...Antoine JC	33045420	2021
31	Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review. ⁶¹	Peralta Suarez G...Tinoco G	33542879	2021
32	[Distinctive Disease Entity of Neurological Adverse Events Associated with Immune Checkpoint Inhibitors]. ⁶¹	Seki M...Suzuki S	33361512	2021
33	New evidence for secondary axonal degeneration in demyelinating neuropathies. ⁶¹	Moss KR...Hoke A	33359733	2021
34	Acute Brucellosis with a Guillain-Barre Syndrome-Like Presentation: A Case Report and Literature Review. ⁶¹	Alanazi A...Alharbi A	33401372	2021
35	Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders. ⁶¹	Rinaldi S...Australian and New Zealand MOG Study Group	33272955	2021
36	Quality of life in chronic inflammatory demyelinating polyneuropathy patients treated with subcutaneous immunoglobulin. ⁶¹	Ryltoft AK...Markvardsen LK	33404110	2020
37	Pathophysiology of Chronic Inflammatory Demyelinating Polyneuropathy: Insights into Classification and Therapeutic Strategy. ⁶¹	Koike H...Katsuno M	32410146	2020
38	Dissociation of axo-glial junction in anti-neurofascin 155 chronic inflammatory demyelinating polyneuropathy. ⁶¹	Lv H...Yuan Y	33261722	2020
39	Peripheral Nerve Enlargement in Chronic Inflammatory Demyelinating Polyneuropathy. ⁶¹	Tanitame K...Kunishige T	33390487	2020
40	Ocrelizumab in a case of refractory chronic inflammatory demyelinating polyneuropathy with anti-rituximab antibodies. ⁶¹	Casertano S...Lus G	32875645	2020
41	Fatigue in chronic inflammatory demyelinating polyneuropathy. ⁶¹	Gable KL...Allen JA	32710648	2020
42	Pulse oral corticosteroids in pediatric chronic inflammatory demyelinating polyneuropathy. ⁶¹	Rogers AB...Connolly AM	32893348	2020
43	Pathological spontaneous activity as a prognostic marker in chronic inflammatory demyelinating polyneuropathy. ⁶¹	Gruter T...Pitarokoili K	32794258	2020
44	Longer-term effects of intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: Who benefits? ⁶¹	Terhoeven P...Linker RA	33035867	2020
45	Electrophysiology of fatigue in chronic inflammatory demyelinating polyneuropathy: Can it be useful? ⁶¹	Goedee HS...van der Pol WL	33250076	2020
46	High Levels of Il-19 in Patients with Chronic Inflammatory Demyelinating Polyneuropathy. ⁶¹	Sangsefidi S...Eftekharian MM	32472395	2020
47	Peripheral nerve electrophysiology studies in relation to fatigue in patients with chronic inflammatory demyelinating polyneuropathy. ⁶¹	Lawley A...Rajabally YA	32928696	2020
48	Clinical, electrophysiological and genetic characteristics of childhood hereditary polyneuropathies. ⁶¹	Paketci C...Yis U	32709422	2020
49	Cranial nerve involvement in typical and atypical chronic inflammatory demyelinating polyneuropathies. ⁶¹	Shibuya K...Kuwabara S	32876980	2020
50	Refractory CIDP with chronic lymphocytic leukaemia responding to chemoimmunotherapy. ⁶¹	Lewis D...Katifi HA	33376152	2020

Sources

Genes for Demyelinating Polyneuropathy

Genes related to Demyelinating Polyneuropathy (0 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMP22	Peripheral Myelin Protein 22	Protein Coding	23.6	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
2	NFASC	Neurofascin	Protein Coding	15.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MAG	Myelin Associated Glycoprotein	Protein Coding	15.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CNTN1	Contactin 1	Protein Coding	14.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	TTR	Transthyretin	Protein Coding	13.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	FCGR2B	Fc Fragment Of IgG Receptor IIb	Protein Coding	13.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CNTN2	Contactin 2	Protein Coding	13.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	ALB	Albumin	Protein Coding	12.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	NGF	Nerve Growth Factor	Protein Coding	11.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	11.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CLDN5	Claudin 5	Protein Coding	11.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	AIF1	Allograft Inflammatory Factor 1	Protein Coding	11.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	HP	Haptoglobin	Protein Coding	11.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	CD52	CD52 Molecule	Protein Coding	11.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	GAS6	Growth Arrest Specific 6	Protein Coding	11.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	IFNA2	Interferon Alpha 2	Protein Coding	11.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	MMP9	Matrix Metallopeptidase 9	Protein Coding	11.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	AIRE	Autoimmune Regulator	Protein Coding	11.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	PTGDS	Prostaglandin D2 Synthase	Protein Coding	11.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	CD1D	CD1d Molecule	Protein Coding	11.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	10.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	IL18	Interleukin 18	Protein Coding	10.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	10.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	TJP1	Tight Junction Protein 1	Protein Coding	10.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Demyelinating Polyneuropathy

ClinVar genetic disease variations for Demyelinating Polyneuropathy:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	KIF5A	NM_004984.4(KIF5A):c.2005G>A (p.Ala669Thr)	SNV	Uncertain significance	816537	rs142495781	12:57969522-57969522	12:57575739-57575739

Sources

Expression for Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Demyelinating Polyneuropathy.

Sources

Pathways for Demyelinating Polyneuropathy

Pathways related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Spinal Cord Injury ¹	11.34	TNFSF13B MMP9 MAG AIF1
2	Cell adhesion molecules ³⁶	11.19	NFASC MAG CNTN2 CNTN1 CLDN5

Sources

GO Terms for Demyelinating Polyneuropathy

Cellular components related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.85	TTR TNFSF13B PTGDS NGF MMP9 IFNA2
2	node of Ranvier	GO:0033268	9.37	NFASC CNTN2
3	paranode region of axon	GO:0033270	9.32	MAG CLDN5
4	extracellular space	GO:0005615	9.32	TTR TNFSF13B PTGDS NGF MMP9 IFNA2
5	Schmidt-Lanterman incisure	GO:0043220	9.26	MAG CLDN5
6	anchored component of postsynaptic membrane	GO:0099025	8.96	CNTN2 CNTN1

Biological processes related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.72	NGF MMP9 GAS6 ALB AIF1
2	transmission of nerve impulse	GO:0019226	9.37	NFASC MAG
3	positive regulation of T cell proliferation	GO:0042102	9.33	TNFSF13B CD1D AIF1
4	central nervous system myelination	GO:0022010	9.26	MAG CNTN2
5	cerebellum development	GO:0021549	9.13	FCGR2B CNTN1 AIF1
6	peripheral nervous system development	GO:0007422	8.8	PMP22 NGF NFASC

Sources

Sources for Demyelinating Polyneuropathy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹³ diseasecard

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia