MCID: DND003
MIFTS: 24

Dendritic Cell Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Dendritic Cell Thymoma

MalaCards integrated aliases for Dendritic Cell Thymoma:

Name: Dendritic Cell Thymoma 12 15
Epithelioid Thymoma 12
Type B Thymoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3282
NCIt 50 C7114
UMLS 73 C1328042

Summaries for Dendritic Cell Thymoma

MalaCards based summary : Dendritic Cell Thymoma, also known as epithelioid thymoma, is related to ectopic thymus and intravascular large b-cell lymphoma. An important gene associated with Dendritic Cell Thymoma is CD5 (CD5 Molecule), and among its related pathways/superpathways are IL-2 Signaling Pathway and NF-kappa B signaling pathway. The drugs Nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and thymus, and related phenotype is Decreased vesicular stomatitis virus (VSV) infection.

Related Diseases for Dendritic Cell Thymoma

Diseases related to Dendritic Cell Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 ectopic thymus 10.0 BCL2 CD5
2 intravascular large b-cell lymphoma 10.0 BCL2 CD5
3 thymus gland disease 10.0 CD5 TTN
4 autoimmune lymphoproliferative syndrome, type v 10.0 BCL2 CD5
5 lymphatic system disease 10.0 CD5 TTN
6 marginal zone b-cell lymphoma 10.0 BCL2 CD5
7 cortical thymoma 10.0 CD58 TTN
8 lymphoma, mucosa-associated lymphoid type 9.9 BCL2 CD5
9 cd45 deficiency 9.9 CD5 LCK
10 mantle cell lymphoma 9.8 BCL2 CD5
11 thymoma 9.8 CD5 LCK TTN
12 spindle cell thymoma 9.7 CD5 CD58 LCK
13 epithelial malignant thymoma 9.3 BCL2 CD5 CD58 LCK ZBTB33

Graphical network of the top 20 diseases related to Dendritic Cell Thymoma:



Diseases related to Dendritic Cell Thymoma

Symptoms & Phenotypes for Dendritic Cell Thymoma

GenomeRNAi Phenotypes related to Dendritic Cell Thymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00356-A-1 8.62 LCK TTN

Drugs & Therapeutics for Dendritic Cell Thymoma

Drugs for Dendritic Cell Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2
5 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab in Patients With Type B3 Thymoma and Thymic Carcinoma (NIVOTHYM) Recruiting NCT03134118 Phase 2 Nivolumab

Search NIH Clinical Center for Dendritic Cell Thymoma

Genetic Tests for Dendritic Cell Thymoma

Anatomical Context for Dendritic Cell Thymoma

MalaCards organs/tissues related to Dendritic Cell Thymoma:

41
Lymph Node, B Cells, Thymus

Publications for Dendritic Cell Thymoma

Articles related to Dendritic Cell Thymoma:

# Title Authors Year
1
Fine-Needle Aspiration Biopsy for the Diagnosis of Metastatic Type B Thymoma to Lymph Nodes: A Case Report. ( 23456993 )
2013
2
Proteome analysis and tissue array for profiling protein markers associated with type B thymoma subclassification. ( 22932072 )
2012
3
Type B thymoma: is prognosis predicted only by World Health Organization classification? ( 20038470 )
2010

Variations for Dendritic Cell Thymoma

Expression for Dendritic Cell Thymoma

Search GEO for disease gene expression data for Dendritic Cell Thymoma.

Pathways for Dendritic Cell Thymoma

Pathways related to Dendritic Cell Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 BCL2 LCK
2 10.93 BCL2 LCK
3
Show member pathways
10.45 BCL2 LCK

GO Terms for Dendritic Cell Thymoma

Biological processes related to Dendritic Cell Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell receptor signaling pathway GO:0050853 9.37 BCL2 LCK
2 regulation of catalytic activity GO:0050790 9.32 BCL2 TTN
3 hemopoiesis GO:0030097 9.26 BCL2 LCK
4 T cell costimulation GO:0031295 9.16 CD5 LCK
5 T cell differentiation GO:0030217 8.96 BCL2 LCK
6 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 8.62 BCL2 LCK

Molecular functions related to Dendritic Cell Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 BCL2 TTN
2 protein phosphatase binding GO:0019903 8.62 BCL2 LCK

Sources for Dendritic Cell Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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