DF
MCID: DNG003
MIFTS: 66

Dengue Disease (DF)

Categories: Blood diseases, Genetic diseases, Immune diseases, Infectious diseases, Liver diseases, Rare diseases, Skin diseases

Aliases & Classifications for Dengue Disease

MalaCards integrated aliases for Dengue Disease:

Name: Dengue Disease 38 12 15
Dengue Fever 12 76 53 3 15 73
Dengue 55 43 44
Dengue Shock Syndrome 53 73
Df 53 3
Philippine Hemorrhagic Fever 53
Singapore Hemorrhagic Fever 53
Dengue Hemorrhagic Fever 53
Dengue Virus Infection 53
Thai Hemorrhagic Fever 53
Hemorrhagic Dengue 53
Classical Dengue 12
Breakbone Fever 12
Classic Dengue 12
Severe Dengue 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12205
ICD10 33 A90
ICD9CM 35 061
MeSH 44 D003715
NCIt 50 C34528
SNOMED-CT 68 38362002

Summaries for Dengue Disease

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 99828Disease definitionDengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).EpidemiologyDF is found in the tropics worldwide, especially in Southeast Asia, the Pacific region, and the Americas, with 40% of the global population at risk. An estimated 50 to 100 million cases of DF, 500,000 hospitalizations, and 20,000 deaths occur yearly worldwide.Clinical descriptionThe vast majority of dengue virus infections result in DF, which is characterized by sudden onset of fever, malaise, headache (classically retro-orbital), and myalgia/arthralgia, often followed soon after by a petechial rash, which may be pruritic. In most cases, symptoms will resolve within 7 days without further complications. However, in a small minority of patients, a brief period of deffervescence is followed by worsening abdominal symptoms (pain, nausea, vomiting, diarrhea), thrombocytopenia, hemorrhage (DHF: epistaxis, bleeding gums, gastrointestinal bleeding) and a capillary leak syndrome (DSS: hemoconcentration, hypoalbuminemia, pleural effusion, shock). DHF/DSS are seen most often in children under the age of 15 years. Risk is greater with secondary heterologous infection by one of the four dengue virus serotypes, but severe disease may be seen with first infections.EtiologyOver 25 different viruses cause viral hemorrhagic fever. Dengue virus belongs to the Flaviviridae family, genus Flavivirus. Four distinct serotypes, with significant strain variation, are recognized. Dengue viruses are maintained in humans and transmitted between them by the bite of infected mosquitoes, most commonly Aedes aegypti but also Aedes albopictus). Person-to-person transmission has not been reported.Diagnostic methodsCommon diagnostic modalities include serologic testing by enzyme linked immunosorbent assay (ELISA) and reverse transcriptionpolymerase chain reaction (RT-PCR). Virus isolation may also be performed in specialized laboratories. The viremic phase of DF/DHF is usually brief (first 3-5 days of illness), after which time detection of anti-dengue IgM antibodies, which appear as early as 2-4 days after disease onset, is the mainstay. Numerous commercial ELISA assays are available with varying degrees of sensitivity and specificity.Differential diagnosisDF is difficult to distinguish from a host of other febrile illnesses such as malaria and typhoid fever (see these terms), especially early in the course of disease before the rash appears. For DHF/DSS, other viral hemorrhagic fevers, leptospirosis, rickettsial infection (see these terms) and meningococcemia need to be excluded.Management and treatmentAs there is presently no antiviral drug available for DF/DHF, treatment is supportive, following the guidelines for treatment of severe septicemia. Insecticide-treated bed nets, room screens and elimination of larval development sites should be used in open-air settings to prevent further transmission.PrognosisCase-fatality rates for DF are less than 1% but may rise to as high as 40% in DHF/DSS, largely dependent upon whether access to advanced medical care exists. Children and persons with underlying chronic diseases such as diabetes, heart disease, and asthma are at increased risk. The most severe phase of disease usually lasts only a few days and survivors generally have no lasting sequelae.Visit the Orphanet disease page for more resources.

MalaCards based summary : Dengue Disease, also known as dengue fever, is related to viral infectious disease and lymphocytic vasculitis, and has symptoms including fever and pruritus. An important gene associated with Dengue Disease is NEAT1 (Nuclear Paraspeckle Assembly Transcript 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Interferon gamma signaling. The drugs Pharmaceutical Solutions and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.

MedlinePlus : 43 Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Dengue does not spread from person to person. It is common in warm, wet areas of the world. Outbreaks occur in the rainy season. Dengue is rare in the United States. Symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. In some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. It can also become dengue shock syndrome, which causes massive bleeding and shock. These forms of dengue are life-threatening. There is no specific treatment. Most people with dengue recover within 2 weeks. Until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. People with the more severe forms of dengue usually need to go to the hospital and get fluids. To lower your risk when traveling to areas where dengue is found Wear insect repellent with DEET Wear clothes that cover your arms, legs and feet Close unscreened doors and windows NIH: National Institute of Allergy and Infectious Diseases

Wikipedia : 76 Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin... more...

Related Diseases for Dengue Disease

Diseases in the Dengue Virus family:

Dengue Disease

Diseases related to Dengue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 328)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 30.4 CCL5 CD209 CD40LG
2 lymphocytic vasculitis 30.1 ICAM1 VCAM1
3 vasculitis 30.0 CD40LG ICAM1 VCAM1
4 rhinitis 30.0 CCL5 ICAM1 VCAM1
5 pneumonia 29.8 CCL5 CD40LG MBL2 PIK3C2A
6 trypanosomiasis 29.8 CCL5 ICAM1 VCAM1
7 asthma 29.8 CCL5 CD40LG ICAM1 IL11 VCAM1
8 glomerulonephritis 29.5 CD40LG ICAM1 VCAM1
9 systemic lupus erythematosus 29.3 CCL5 CD40LG FCGR1A ICAM1 MBL2 NEAT1
10 zika fever 11.5
11 dengue hemorrhagic fever 11.3
12 kyasanur forest disease 11.1
13 dengue shock syndrome 11.0
14 asymptomatic dengue 11.0
15 chikungunya 10.5
16 acute liver failure 10.4
17 pancreatitis 10.4
18 encephalopathy 10.3
19 leptospirosis 10.3
20 cortical thymoma 10.2 ICAM1 VCAM1
21 mooren's ulcer 10.2 ICAM1 VCAM1
22 acquired thrombocytopenia 10.2 IL11 THPO
23 shwartzman phenomenon 10.2 ICAM1 VCAM1
24 infantile liver failure syndrome 1 10.2
25 hemophagocytic lymphohistiocytosis 10.2
26 pituitary apoplexy 10.2
27 panophthalmitis 10.2
28 acute pancreatitis 10.2
29 subendocardial myocardial infarction 10.2 ICAM1 VCAM1
30 actinic prurigo 10.2 ICAM1 VCAM1
31 immunoglobulin g deficiency 10.2 CD40LG MBL2
32 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.2
33 myelitis 10.2
34 brachydactyly, type e2 10.2 ICAM1 VCAM1
35 immune-complex glomerulonephritis 10.2 ICAM1 VCAM1
36 secondary syphilis 10.2 CD209 CD40LG
37 diabetes mellitus, ketosis-prone 10.2
38 myocarditis 10.2
39 guillain-barre syndrome 10.2
40 african tick-bite fever 10.2 CCL5 CD40LG
41 chylothorax, congenital 10.2 PTPN11 VCAM1
42 chronic conjunctivitis 10.2 CCL5 ICAM1
43 relapsing-remitting multiple sclerosis 10.1 CCL5 ICAM1 NEAT1
44 rheumatoid vasculitis 10.1 ICAM1 VCAM1
45 oral lichen planus 10.1 CCL5 ICAM1 VCAM1
46 proteasome-associated autoinflammatory syndrome 1 10.1 CCL5 ICAM1 VCAM1
47 chronic eosinophilic pneumonia 10.1 CCL5 ICAM1
48 intestine carcinoma in situ 10.1 CD40LG ICAM1
49 status asthmaticus 10.1 CCL5 PIK3C2A
50 appendicitis 10.1

Graphical network of the top 20 diseases related to Dengue Disease:



Diseases related to Dengue Disease

Symptoms & Phenotypes for Dengue Disease

UMLS symptoms related to Dengue Disease:


fever, pruritus

MGI Mouse Phenotypes related to Dengue Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL5 CD40LG FCGR1A ICAM1 MBL2 PIK3C2A
2 immune system MP:0005387 9.28 CCL5 CD40LG FCGR1A ICAM1 MBL2 PIK3C2A

Drugs & Therapeutics for Dengue Disease

Drugs for Dengue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3
2 Immunologic Factors Phase 3,Phase 2,Phase 1
3 Vaccines Phase 3,Phase 2,Phase 1,Not Applicable
4 Heptavalent Pneumococcal Conjugate Vaccine Phase 2
5 Immunoglobulins Phase 1,Not Applicable
6 Antibodies Phase 1,Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Unknown status NCT01374516 Phase 3
2 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
3 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
4 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed NCT00880893 Phase 2
5 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed NCT00842530 Phase 2
6 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed NCT00788151 Phase 2
7 Immunogenicity and Safety of Different Vaccination Schedules of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age Active, not recruiting NCT02628444 Phase 2
8 Evaluation of the Safety and the Ability of a DNA Vaccine to Protect Against Dengue Disease Completed NCT01502358 Phase 1
9 Safety Study of a Vaccine (DENV-1 PIV) to Prevent Dengue Disease Completed NCT01502735 Phase 1
10 Tetravalent Chimeric Dengue Vaccine Trial Completed NCT01110551 Phase 1 Placebo (SC);Placebo (ID)
11 Study to Evaluate the Incidence, Clinical Characteristics and Economic Burden of Dengue in Brazilian Children Completed NCT01391819 Not Applicable
12 Cohort Event Monitoring for Dengvaxia®, CYD-TDV Dengue Vaccine Active, not recruiting NCT02948933

Search NIH Clinical Center for Dengue Disease

Cochrane evidence based reviews: dengue

Genetic Tests for Dengue Disease

Anatomical Context for Dengue Disease

MalaCards organs/tissues related to Dengue Disease:

41
Skin, Testes, Bone, Heart, Eye, Liver, Kidney

Publications for Dengue Disease

Articles related to Dengue Disease:

(show top 50) (show all 1153)
# Title Authors Year
1
Raman spectroscopy based differentiation of typhoid and dengue fever in infected human sera. ( 30114579 )
2019
2
Seroprevalence of dengue fever and the associated sociodemographic, clinical, and environmental factors in Makkah, Madinah, Jeddah, and Jizan, Kingdom of Saudi Arabia. ( 30244133 )
2019
3
Implications of meteorological and physiographical parameters on dengue fever occurrences in Delhi. ( 30292120 )
2019
4
Epidemiological trends and risk factors associated with dengue disease in Pakistan (1980-2014): a systematic literature search and analysis. ( 29907109 )
2018
5
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome. ( 29447178 )
2018
6
Models to assess the effects of non-identical sex ratio augmentations of Wolbachia-carrying mosquitoes on the control of dengue disease. ( 29530790 )
2018
7
Dynamics of dengue disease with human and vector mobility. ( 29751893 )
2018
8
Post Dengue Fever Epidural abscess with or without Spondylodiscitis-a Case series of 8 patients in a single season in a single Centre: Do the dengue has a predilection for the Neural tissue? ( 29979359 )
2018
9
Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever in Mexico from 1995-2015. ( 29402463 )
2018
10
Travel-acquired Scrub Typhus Infection Masked by Dengue Fever in a Patient from Nonendemic Area. ( 29910575 )
2018
11
Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever. ( 29929827 )
2018
12
Acute Pancreatitis in Dengue Fever. ( 29076099 )
2018
13
Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil. ( 30379229 )
2018
14
ERRATUM: Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil. ( 30540019 )
2018
15
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. ( 30059498 )
2018
16
Clinical profile of dengue fever and coinfection with chikungunya. ( 30069124 )
2018
17
The Burden of Dengue Fever and Chikungunya in Southern Coastal Ecuador: Epidemiology, Clinical Presentation, and Phylogenetics from the First Two Years of a Prospective Study. ( 29512482 )
2018
18
Space-time clusters and co-occurrence of chikungunya and dengue fever in Colombia from 2015 to 2016. ( 29709630 )
2018
19
Role of TNF α, IL-6 and CXCL10 in Dengue disease severity. ( 30112159 )
2018
20
M2 macrophage subset decrement is an indicator of bleeding tendency in pediatric dengue disease. ( 30196007 )
2018
21
Two-level resolution of relative risk of dengue disease in a hyperendemic city of Colombia. ( 30204762 )
2018
22
SIR Model for Dengue Disease with Effect of Dengue Vaccination. ( 30228830 )
2018
23
Comparison between the traditional (1997) and revised (2009) WHO classifications of dengue disease: a retrospective study of 30 670 patients. ( 30282115 )
2018
24
Using Google Trends to Examine the Spatio-Temporal Incidence and Behavioral Patterns of Dengue Disease: A Case Study in Metropolitan Manila, Philippines. ( 30423898 )
2018
25
Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice. ( 30439343 )
2018
26
Clinical profile and predictors of Severe Dengue disease: A study from South India. ( 30510647 )
2018
27
Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome. ( 30105961 )
2018
28
Complete Coding Sequences of Dengue Virus Type 2 Strains from Febrile Patients Seen in Malindi District Hospital, Kenya, during the 2017 Dengue Fever Outbreak. ( 29650565 )
2018
29
Dengue fever with encephalitis: a rare phenomenon. ( 29909394 )
2018
30
Post Dengue Fever Epidural Abscess With or Without Spondylodiscitis: A Case Series of Eight Patients in a Single Season in a Single Center: Does the Dengue Have a Predilection for the Neural Tissue? ( 30507729 )
2018
31
Chicory (Cichorium intybus) and wormwood (Artemisia absinthium) extracts exhibit strong larvicidal activity against mosquito vectors of malaria, dengue fever, and filariasis. ( 30118862 )
2018
32
Dengue fever complicated with Guillain-Barré syndrome: a case report and review of the literature. ( 29759074 )
2018
33
Dengue fever manifesting with tetany as the first presentation of primary hypoparathyroidism: a case report. ( 30107822 )
2018
34
Dengue fever-associated necrotizing scleritis: A case report with long-term follow-up. ( 30095666 )
2018
35
An unusual occurrence of stromal keratitis in dengue fever. ( 30355887 )
2018
36
Cerebral vasculitis and lateral rectus palsy - two rare central nervous system complications of dengue fever: two case reports and review of the literature. ( 29669602 )
2018
37
Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis. ( 29990356 )
2018
38
Dengue fever during pregnancy. ( 29915441 )
2018
39
Reversible splenial lesion syndrome associated with dengue fever: a case report. ( 29945676 )
2018
40
Latest Updates in Dengue Fever Therapeutics: Natural, Marine, and Synthetic Drugs. ( 29956614 )
2018
41
International Travel and Exotic Dengue Fever in South Korea from 2006 to 2015. ( 29962484 )
2018
42
Elevated cardiac biomarkers and echocardiographic left ventricular dysfunction at admission in patients with dengue fever: report from a tertiary care center in Northwest India. ( 29991327 )
2018
43
A model comparison algorithm for increased forecast accuracy of dengue fever incidence in Singapore and the auxiliary role of total precipitation information. ( 30016117 )
2018
44
Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan. ( 30053811 )
2018
45
Feasibility of mapping of dengue fever patients admitted to medical wards of Teaching Hospital Karapitiya using Google maps®app in mobile phones or tablets ( 30064189 )
2018
46
Is there a real increased risk of stroke in patients with dengue fever? ( 30087131 )
2018
47
The authors respond to "Is there a real increased risk of stroke in patients with dengue fever?" ( 30087132 )
2018
48
Spontaneous intracranial hemorrhage associated with dengue fever: An emerging concern for general physicians. ( 30112320 )
2018
49
Lipid peroxidation, DNA damage, and apoptosis in dengue fever. ( 30120880 )
2018
50
Spatial analysis of dengue fever and exploration of its environmental and socio-economic risk factors using ordinary least squares: A case study in five districts of Guangzhou City, China, 2014. ( 30121308 )
2018

Variations for Dengue Disease

Expression for Dengue Disease

LifeMap Discovery
Genes differentially expressed in tissues of Dengue Disease patients vs. healthy controls: 35 (show top 50) (show all 93)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 IFI27 interferon, alpha-inducible protein 27 Blood + 4.85 0.000
2 RRM2 ribonucleotide reductase M2 Blood + 4.48 0.000
3 CEP55 centrosomal protein 55kDa Blood + 4.33 0.000
4 BIRC5 baculoviral IAP repeat containing 5 Blood + 4.30 0.000
5 XIST X inactive specific transcript (non-protein coding) Blood - 4.25 0.009
6 CD38 CD38 molecule Blood + 4.23 0.000
7 DLGAP5 discs, large (Drosophila) homolog-associated protein 5 Blood + 4.10 0.000
8 BUB1 BUB1 mitotic checkpoint serine/threonine kinase Blood + 4.08 0.000
9 IGHM immunoglobulin heavy constant mu Blood + 4.04 0.000
10 MCM10 minichromosome maintenance 10 replication initiation factor Blood + 3.99 0.000
11 SHCBP1 SHC SH2-domain binding protein 1 Blood + 3.97 0.000
12 PBK PDZ binding kinase Blood + 3.97 0.000
13 TYMS thymidylate synthetase Blood + 3.96 0.000
14 PI3 peptidase inhibitor 3, skin-derived Blood - 3.93 0.000
15 CDCA2 cell division cycle associated 2 Blood + 3.91 0.000
16 SESN3 sestrin 3 Blood - 3.90 0.000
17 HMMR hyaluronan-mediated motility receptor (RHAMM) Blood + 3.83 0.000
18 MKI67 marker of proliferation Ki-67 Blood + 3.83 0.000
19 ZWINT ZW10 interacting kinetochore protein Blood + 3.83 0.000
20 DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) Blood + 3.80 0.000
21 CDK1 cyclin-dependent kinase 1 Blood + 3.78 0.000
22 NCAPG non-SMC condensin I complex, subunit G Blood + 3.76 0.000
23 CDT1 chromatin licensing and DNA replication factor 1 Blood + 3.76 0.000
24 SPC25 SPC25, NDC80 kinetochore complex component Blood + 3.75 0.000
25 CDC20 cell division cycle 20 Blood + 3.73 0.000
26 CNTNAP3 contactin associated protein-like 3 Blood - 3.72 0.000
27 TOP2A topoisomerase (DNA) II alpha Blood + 3.71 0.000
28 NOV nephroblastoma overexpressed Blood - 3.71 0.000
29 EIF1AY eukaryotic translation initiation factor 1A, Y-linked Blood + 3.69 0.015
30 CCNB2 cyclin B2 Blood + 3.62 0.000
31 CDKN3 cyclin-dependent kinase inhibitor 3 Blood + 3.62 0.000
32 KIAA0101 KIAA0101 Blood + 3.61 0.000
33 KIF2C kinesin family member 2C Blood + 3.60 0.000
34 TK1 thymidine kinase 1, soluble Blood + 3.59 0.000
35 RPS4Y1 ribosomal protein S4, Y-linked 1 Blood + 3.57 0.017
36 TTK TTK protein kinase Blood + 3.56 0.000
37 CDC6 cell division cycle 6 Blood + 3.56 0.000
38 CAV1 caveolin 1, caveolae protein, 22kDa Blood + 3.56 0.000
39 CENPA centromere protein A Blood + 3.54 0.000
40 CYAT1 immunoglobulin lambda light chain-like Blood + 3.52 0.000
41 ASPM abnormal spindle microtubule assembly Blood + 3.52 0.000
42 OR2W3 olfactory receptor, family 2, subfamily W, member 3 Blood - 3.51 0.000
43 UHRF1 ubiquitin-like with PHD and ring finger domains 1 Blood + 3.50 0.000
44 SELENBP1 selenium binding protein 1 Blood - 3.50 0.000
45 GINS2 GINS complex subunit 2 (Psf2 homolog) Blood + 3.49 0.000
46 MELK maternal embryonic leucine zipper kinase Blood + 3.47 0.000
47 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B Blood + 3.47 0.000
48 CHEK1 checkpoint kinase 1 Blood + 3.46 0.000
49 CCNB1 cyclin B1 Blood + 3.45 0.000
50 KIF11 kinesin family member 11 Blood + 3.42 0.000
Search GEO for disease gene expression data for Dengue Disease.

Pathways for Dengue Disease

Pathways related to Dengue Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 CCL5 CD40LG FCGR1A ICAM1 IL11 PTPN11
2
Show member pathways
12.32 FCGR1A ICAM1 PTPN11 VCAM1
3 11.94 CD209 FCGR1A MBL2
4 11.91 CD40LG ICAM1 VCAM1
5 11.87 IL11 THPO VCAM1
6 11.8 CD209 IL11 THPO
7
Show member pathways
11.79 CCL5 CD209 HCFC1 ICAM1 IVNS1ABP PTPN11
8 11.75 CCL5 ICAM1 VCAM1
9 11.67 FCGR1A IL11 THPO
10 11.65 CD40LG ICAM1 VCAM1
11 11.61 CCL5 ICAM1 IL11
12
Show member pathways
11.57 CCL5 ICAM1 IL11 PTPN11 THPO
13
Show member pathways
11.43 CD40LG ICAM1 VCAM1
14 11.39 CD40LG FCGR1A ICAM1 VCAM1
15 11.33 FCGR1A ICAM1 MBL2
16 11.23 CD40LG ICAM1 VCAM1
17 11.14 ICAM1 PTPN11 VCAM1
18 11.08 ICAM1 IL11 PTPN11
19 10.75 ICAM1 VCAM1

GO Terms for Dengue Disease

Cellular components related to Dengue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CCL5 CD40LG ICAM1 IL11 MBL2 THPO
2 external side of plasma membrane GO:0009897 9.26 CD209 CD40LG ICAM1 VCAM1
3 cell surface GO:0009986 9.02 CD209 CD40LG ICAM1 MBL2 VCAM1

Biological processes related to Dengue Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL5 ICAM1 PTPN11 THPO
2 cellular response to tumor necrosis factor GO:0071356 9.69 CCL5 ICAM1 VCAM1
3 regulation of immune response GO:0050776 9.67 CD40LG FCGR1A ICAM1 VCAM1
4 B cell differentiation GO:0030183 9.61 CD40LG IL11 VCAM1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.58 FCGR1A ICAM1 VCAM1
6 cytokine-mediated signaling pathway GO:0019221 9.55 CCL5 ICAM1 IL11 PTPN11 VCAM1
7 regulation of protein complex assembly GO:0043254 9.49 HCFC1 PTPN11
8 negative regulation of hormone secretion GO:0046888 9.48 IL11 PTPN11
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 CD209 ICAM1 VCAM1
10 membrane to membrane docking GO:0022614 9.32 ICAM1 VCAM1
11 positive regulation of T cell proliferation GO:0042102 9.26 CCL5 CD209 CD40LG VCAM1
12 leukocyte cell-cell adhesion GO:0007159 9.02 CCL5 CD209 CD40LG ICAM1 VCAM1

Molecular functions related to Dengue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mannose binding GO:0005537 8.96 CD209 MBL2
2 cytokine activity GO:0005125 8.92 CCL5 CD40LG IL11 THPO

Sources for Dengue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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