DSS
MCID: DNG001
MIFTS: 40

Dengue Shock Syndrome (DSS)

Categories: Infectious diseases

Aliases & Classifications for Dengue Shock Syndrome

MalaCards integrated aliases for Dengue Shock Syndrome:

Name: Dengue Shock Syndrome 12 54 15 71
Dss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050125
UMLS 71 C0376300

Summaries for Dengue Shock Syndrome

Disease Ontology : 12 A dengue disease that involves the most severe form of dengue fever, has material basis in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom easy bruising, has symptom blood spots, has symptom bleeding gums, and has symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

MalaCards based summary : Dengue Shock Syndrome, also known as dss, is related to dengue disease and colitis, and has symptoms including easy bruising, blood spots and bleeding gums. An important gene associated with Dengue Shock Syndrome is THBD (Thrombomodulin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Pharmaceutical Solutions and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and monocytes.

Related Diseases for Dengue Shock Syndrome

Diseases related to Dengue Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 583)
# Related Disease Score Top Affiliating Genes
1 dengue disease 32.8 TNF SULT1A3 SENP8 CD209
2 colitis 32.0 TNF IL6 IL1RN IL1B HLA-DRB1
3 ulcerative colitis 31.6 TNF IL6 IL1RN IL1B HLA-DRB1
4 dengue hemorrhagic fever 31.4 TNF IL6 HLA-A CMA1 CD209
5 exanthem 30.8 VEGFA TNF IL6 IL1B
6 crohn's disease 30.6 TNF IL6 IL1B HLA-DRB1 CCL2
7 inflammatory bowel disease 30.6 VEGFA TNF MICB IL6 IL1RN IL1RAPL2
8 aspergillosis 30.6 TNF IL6 IL1B CD209
9 myocarditis 30.6 TNF IL6 IL1B CCL2
10 cardiogenic shock 30.5 TNF IL6
11 helicobacter pylori infection 30.5 TNF IL1RN IL1B
12 acute kidney tubular necrosis 30.5 TNF IL6 CCL2
13 bacterial sepsis 30.4 TNF IL6 IL1RN IL1B
14 gastritis 30.4 TNF IL6 IL1RN IL1B
15 toxic shock syndrome 30.4 TNF IL6 IL1RN IL1B
16 purpura 30.4 TNF THBD IL6 IL1B
17 appendicitis 30.4 TNF IL6 IL1B CCL2
18 ileus 30.4 TNF IL6 IL1B CCL2
19 disease by infectious agent 30.3 TNF IL6 IL1RN IL1B CD209
20 polyneuropathy 30.3 VEGFA TNF IL6 IL1B
21 congestive heart failure 30.3 VEGFA TNF IL6 IL1B
22 disseminated intravascular coagulation 30.3 TNF THBD IL6
23 respiratory failure 30.3 VEGFA TNF THBD IL6 IL1RN IL1B
24 urethritis 30.3 TNF IL6 IL1B
25 bacterial infectious disease 30.2 TNF IL6 IL1RN IL1B CCL2
26 sickle cell anemia 30.2 TNF IL6 IL1B HLA-DRB1
27 japanese encephalitis 30.2 TNF CD209 CCL2
28 adult respiratory distress syndrome 30.2 TNF THBD IL6 IL1RN IL1B
29 perinatal necrotizing enterocolitis 30.2 TNF IL6 IL1B
30 peritonitis 30.2 TNF IL6 IL1B CMA1 CCL2
31 parasitic helminthiasis infectious disease 30.2 TNF IL6 IL1B
32 thrombocytopenia 30.2 TNF THBD IL6 IL1RN IL1B HLA-A
33 proteasome-associated autoinflammatory syndrome 1 30.1 TNF IL6 IL1RN IL1RAPL2 IL1B CCL2
34 encephalitis 30.1 TNF IL6 IL1B CD209 CCL2
35 irritable bowel syndrome 30.1 TNF IL6 IL1B
36 dysentery 30.1 TNF IL6 IL1RAPL2 IL1B
37 cystitis 30.1 VEGFA TNF IL6 CCL2
38 severe acute respiratory syndrome 29.9 TNF IL6 IL1B HLA-A CD209 CCL2
39 autoimmune disease 29.9 TNF IL6 IL1RN IL1RAPL2 IL1B HLA-DRB1
40 covid-19 29.9 IL6 IL1B CCL2
41 post-traumatic stress disorder 29.9 IL1RN IL1B CCL2
42 liver cirrhosis 29.8 VEGFA TNF IL6 IL1B HLA-DRB1
43 multiple sclerosis 29.6 TNF IL6 IL1RN IL1B HLA-DRB1 HLA-A
44 diabetes mellitus 29.5 VEGFA TNF THBD IL6 IL1RN IL1B
45 malaria 29.3 VEGFA TNF THBD SULT1A3 IL6 IL1RN
46 dengue virus 11.3
47 46,xy sex reversal 2 11.3
48 hypertrophic neuropathy of dejerine-sottas 11.3
49 neuropathy, congenital hypomyelinating, 1, autosomal recessive 11.1
50 dysosteosclerosis 11.1

Graphical network of the top 20 diseases related to Dengue Shock Syndrome:



Diseases related to Dengue Shock Syndrome

Symptoms & Phenotypes for Dengue Shock Syndrome

Symptoms:

12
  • easy bruising
  • blood spots
  • bleeding gums
  • nosebleeds

Drugs & Therapeutics for Dengue Shock Syndrome

Drugs for Dengue Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3
2 Immunologic Factors Phase 1
3 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as a Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
2 Phase I Evaluation of the Safety and Immunogenicity of rDEN4delta30 Lot# 109A, a Live Attenuated DEN4 Vaccine, in Healthy Flavivirus-naïve Adult Volunteers. Completed NCT00919178 Phase 1

Search NIH Clinical Center for Dengue Shock Syndrome

Genetic Tests for Dengue Shock Syndrome

Anatomical Context for Dengue Shock Syndrome

MalaCards organs/tissues related to Dengue Shock Syndrome:

40
Endothelial, Liver, Monocytes, Kidney, T Cells, Heart, Skin

Publications for Dengue Shock Syndrome

Articles related to Dengue Shock Syndrome:

(show top 50) (show all 1035)
# Title Authors PMID Year
1
Elevated soluble thrombomodulin in the febrile stage related to patients at risk for dengue shock syndrome. 54 61
17006283 2006
2
Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3beta protein. 61 54
15878791 2005
3
Cytokine patterns during dengue shock syndrome. 61 54
14656693 2003
4
The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome. 61 54
11858187 2002
5
Isolated abducens nerve palsy - A rare clinical presentation in dengue haemorrhagic fever. 61
33602052 2021
6
Acute Demyelinating Polyneuropathy in a Child with Dengue Shock Syndrome. 61
32542487 2021
7
Subacute thyroiditis complicating dengue fever - Case report and brief review of literature. 61
33302815 2020
8
Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand. 61
32773668 2020
9
COVID-19 with dengue shock syndrome in a child: coinfection or cross-reactivity? 61
33370956 2020
10
Genetic association study of interferon lambda 3, CD27, and human leukocyte antigen-DPB1 with dengue severity in Thailand. 61
33308178 2020
11
Assessing the risk of dengue severity using demographic information and laboratory test results with machine learning. 61
33362244 2020
12
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control. 61
32265181 2020
13
Safety of temporary interruption of antiplatelet therapy in dengue fever with thrombocytopenia. 61
33271172 2020
14
Gall Bladder Wall Thickening in Dengue Fever - Aid in Labelling Dengue Hemorrhagic Fever and a Marker of Severity. 61
33304669 2020
15
Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication. 61
32999020 2020
16
Vector Competence for Dengue-2 Viruses Isolated from Patients with Different Disease Severity. 61
33096624 2020
17
Electrochemical Multiplexed Paper Nanosensor for Specific Dengue Serotype Detection Predicting Pervasiveness of DHF/DSS. 61
33320588 2020
18
Establishment of Murine Infection Models with Biological Clones of Dengue Viruses Derived from a Single Clinical Viral Isolate. 61
32451883 2020
19
Cost-efficiency analysis of voluntary vaccination against n-serovar diseases using antibody-dependent enhancement: A game approach. 61
32622789 2020
20
Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico. 61
33138336 2020
21
Assessing dehydration status in dengue patients using urine colourimetry and mobile phone technology. 61
32881914 2020
22
Phylogenetic and recombinant analyses of complete coding sequences of DENV-1 from field-caught mosquitoes in Thailand. 61
32497574 2020
23
Assessment of Severity of Dengue Fever by Deranged Alanine Aminotransferase Levels. 61
33094078 2020
24
Unusual Manifestations of Dengue Fever: A Review on Expanded Dengue Syndrome. 61
33133844 2020
25
Comparison of dengue case classification schemes and evaluation of biological changes in different dengue clinical patterns in a longitudinal follow-up of hospitalized children in Cambodia. 61
32925941 2020
26
Imported dengue serotype 1 outbreak in a non-endemic region, China, 2017: A molecular and seroepidemiological study. 61
32535157 2020
27
Profuse Sweating and Hot Flashes: An Unusual Presentation of Post-Dengue Fatigue Syndrome. 61
32983719 2020
28
Dengue proteins with their role in pathogenesis, and strategies for developing an effective anti-dengue treatment: A review. 61
31784997 2020
29
A Case Report on Dengue Encephalitis With Optic Neuropathy. 61
32923198 2020
30
Dengue Hemorrhagic Fever Complicated With Hemophagocytic Lymphohistiocytosis in an Adult With Diabetic Ketoacidosis. 61
33029452 2020
31
A Rare Case of Dengue Fever Presenting With Acute Disseminated Encephalomyelitis. 61
32983732 2020
32
Double-faced implication of CD4+ Foxp3+ regulatory T cells expanded by acute dengue infection via TLR2/MyD88 pathway. 61
32125695 2020
33
Multiple dengue virus serotypes resistant transgenic Aedes aegypti fitness evaluated under laboratory conditions. 61
32138589 2020
34
Dengue Encephalitis in Children "Not an Uncommon Entity but Is Rarely Thought of": A Case Report. 61
33531952 2020
35
Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target. 61
32545679 2020
36
Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia-Infected Mosquitos and Health Education. 61
32545688 2020
37
An unusual case of dengue shock syndrome complicated by ilio-femoral deep vein thrombosis; a case report. 61
32398134 2020
38
Maternal and Neonatal Outcomes during Dengue Infection Outbreak at a Tertiary National Hospital in Endemic Area of Indonesia. 61
32311872 2020
39
Acute Liver Failure in a Patient With Dengue Shock Syndrome. 61
32548198 2020
40
Interferon lambda 1 is associated with dengue severity in Thailand. 61
31981768 2020
41
Dengue shock syndrome after percutaneous nephrolithotomy leading to hematuria and renal failure: A rare complication. 61
32549667 2020
42
A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India. 61
32346163 2020
43
Daily Dengue Severity Score to Assess Severe Manifestations. 61
31725549 2020
44
The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model. 61
31942645 2020
45
Addition of Partial Envelope Domain II into Envelope Domain III of Dengue Virus Antigen Potentiates the Induction of Virus-Neutralizing Antibodies and Induces Protective Immunity. 61
32075300 2020
46
Diabetic patients suffering dengue are at risk for development of dengue shock syndrome/severe dengue: Emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity. 61
30146413 2020
47
An Attempt Towards Lab And Clinical Combine Appraised, Including Future Concerns Regarding Dengue Infection. 61
32468769 2020
48
A Curious Case of Dengue Fever: A Case Report of Unorthodox Manifestations. 61
32774384 2020
49
Dengue fever complicated with acute liver failure: A case report of expanded dengue syndrome and literature review. 61
32231783 2020
50
Acute kidney injury among thai pediatric patients with dengue shock syndrome: A re-estimation. 61
32129229 2020

Variations for Dengue Shock Syndrome

Expression for Dengue Shock Syndrome

Search GEO for disease gene expression data for Dengue Shock Syndrome.

Pathways for Dengue Shock Syndrome

Pathways related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 VEGFA TNF IL6 IL1RN IL1B HLA-DRB1
2
Show member pathways
12.89 VEGFA TNF MICB IL6 IL1B HLA-A
3
Show member pathways
12.8 VEGFA TNF IL6 IL1B HLA-DRB1 HLA-A
4 12.74 TNF IL6 IL1B HLA-DRB1 HLA-A CCL2
5
Show member pathways
12.63 TPSAB1 TNF IL6 IL1B HLA-DRB1 HLA-A
6 12.31 TNF IL6 HLA-DRB1 HLA-A
7
Show member pathways
12.3 TNF IL6 IL1B CCL2
8
Show member pathways
12.29 TNF IL6 IL1B CCL2
9 12.21 TNF IL6 IL1B CCL2
10
Show member pathways
12.19 TNF IL6 IL1B CD209
11 12.18 TNF IL6 IL1B HLA-DRB1 CD209
12 12.1 VEGFA TNF IL6 IL1RN IL1B
13 12.07 TNF IL6 IL1B CCL2
14 12 VEGFA TNF THBD IL1B CCL2
15 11.98 TNF IL6 IL1B CCL2
16 11.93 TNF IL6 IL1B CCL2
17 11.89 VEGFA TNF IL6 IL1B CCL2
18 11.85 TNF IL6 IL1B HLA-DRB1
19
Show member pathways
11.73 TNF IL6 IL1B
20 11.73 TNF IL6 IL1B
21 11.64 TNF THBD IL6 IL1B CD209
22
Show member pathways
11.61 VEGFA TNF IL6 IL1B
23 11.59 TNF IL6 IL1B
24 11.5 TNF IL1B CCL2
25 11.48 TNF IL6 IL1B CCL2
26 11.47 TNF IL6 IL1B
27 11.45 TNF IL6 IL1B CMA1 CCL2
28 11.4 VEGFA TNF IL6 IL1B HLA-DRB1 CCL2
29 11.37 TNF IL6 IL1B
30 11.34 TNF IL6 IL1B
31 11.32 THBD IL6 CCL2
32 11.29 TNF IL6 IL1B
33 11.26 TNF IL6 IL1B
34 11.24 TNF IL6 IL1RN IL1B CCL2
35 11.17 TNF IL6 IL1B HLA-DRB1
36 11.17 VEGFA TNF THBD PLCE1 IL6 IL1B
37 10.92 TNF IL1B CCL2
38 10.75 IL6 IL1B

GO Terms for Dengue Shock Syndrome

Cellular components related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 VEGFA TPSAB1 TNF IL6 IL1RN IL1B
2 external side of plasma membrane GO:0009897 9.55 TNF THBD MICB HLA-DRB1 CD209
3 cell surface GO:0009986 9.5 VEGFA TNF THBD MICB HLA-DRB1 HLA-A
4 extracellular space GO:0005615 9.4 VEGFA TPSAB1 TNF THBD MICB IL6

Biological processes related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CCL2 IL1B IL1RN IL6 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 HLA-DRB1 TNF VEGFA
3 positive regulation of protein phosphorylation GO:0001934 9.88 HLA-DRB1 IL1B TNF VEGFA
4 cellular response to lipopolysaccharide GO:0071222 9.83 CCL2 IL1B IL6 TNF
5 regulation of insulin secretion GO:0050796 9.8 IL1B IL6 TNF
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 IL6 TNF VEGFA
7 cellular response to organic cyclic compound GO:0071407 9.79 CCL2 IL1B TNF
8 response to glucocorticoid GO:0051384 9.77 IL1RN IL6 TNF
9 positive regulation of interferon-gamma production GO:0032729 9.77 HLA-A IL1B TNF
10 positive regulation of T cell proliferation GO:0042102 9.76 CD209 IL1B IL6
11 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B IL6 TNF
12 humoral immune response GO:0006959 9.72 CCL2 IL6 TNF
13 antigen processing and presentation GO:0019882 9.67 CD209 HLA-A HLA-DRB1
14 detection of bacterium GO:0016045 9.64 HLA-A HLA-DRB1
15 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
16 protein kinase B signaling GO:0043491 9.63 CCL2 IL1B TNF
17 negative regulation of lipid storage GO:0010888 9.62 IL6 TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 CCL2 IL1B TNF
19 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.57 IL1RN IL6
20 immune response GO:0006955 9.56 TNF MICB IL6 IL1RN IL1B HLA-DRB1
21 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6 TNF
22 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
23 positive regulation of glial cell proliferation GO:0060252 9.5 IL1B IL6 TNF
24 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
26 positive regulation of neuroinflammatory response GO:0150078 9.43 IL1B IL6 TNF
27 vascular endothelial growth factor production GO:0010573 9.33 IL1B IL6 TNF
28 cytokine-mediated signaling pathway GO:0019221 9.17 VEGFA TNF IL6 IL1RN IL1RAPL2 IL1B

Molecular functions related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor binding GO:0042608 9.16 HLA-DRB1 HLA-A
2 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-A CD209
3 cytokine activity GO:0005125 9.1 VEGFA TNF IL6 IL1RN IL1B CCL2

Sources for Dengue Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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