DSS
MCID: DNG001
MIFTS: 48

Dengue Shock Syndrome (DSS)

Categories: Infectious diseases

Aliases & Classifications for Dengue Shock Syndrome

MalaCards integrated aliases for Dengue Shock Syndrome:

Name: Dengue Shock Syndrome 12 56 15 74
Dss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050125
UMLS 74 C0376300

Summaries for Dengue Shock Syndrome

Disease Ontology : 12 A dengue disease that involves the most severe form of dengue fever, has material basis in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom easy bruising, has symptom blood spots, has symptom bleeding gums, and has symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

MalaCards based summary : Dengue Shock Syndrome, also known as dss, is related to colitis and ulcerative colitis, and has symptoms including easy bruising, bleeding gums and blood spots. An important gene associated with Dengue Shock Syndrome is THBD (Thrombomodulin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Ketotifen and Histamine have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and endothelial.

Related Diseases for Dengue Shock Syndrome

Diseases related to Dengue Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 colitis 31.9 IL1B IL6 TNF
2 ulcerative colitis 31.1 IL1B IL6 TNF
3 hemorrhagic fever 30.8 HLA-DRB1 IL6 TNF
4 dengue hemorrhagic fever 30.0 CMA1 HLA-A HLA-DRB1 IL6 TNF
5 perinatal necrotizing enterocolitis 29.9 IL1B IL6 TNF
6 acute respiratory distress syndrome 29.8 IL1B IL6 TNF
7 purpura 29.8 IL6 THBD TNF
8 multiple sclerosis 29.0 CCL2 HLA-DRB1 IL1B IL6 TNF
9 diabetes mellitus 28.7 HLA-A HLA-DRB1 IL1B IL1RN IL6 TNF
10 malaria 27.6 CCL2 HLA-A HLA-DRB1 IL1B IL1RN IL6
11 dengue disease 12.3
12 dengue virus 11.6
13 hypertrophic neuropathy of dejerine-sottas 11.4
14 46,xy sex reversal 2 11.4
15 neuropathy, congenital hypomyelinating, 1, autosomal recessive 11.3
16 neuropathy, congenital hypomyelinating, 2 11.2
17 charcot-marie-tooth disease, demyelinating, type 4f 11.1
18 schnitzler syndrome 10.4 IL1B IL1RN
19 colorectal cancer 10.4
20 pustulosis of palm and sole 10.4 IL1RN TNF
21 retinitis pigmentosa 60 10.4 IL1B TNF
22 burns 10.4 IL1B TNF
23 crohn's colitis 10.4 IL1B TNF
24 cerebral artery occlusion 10.4 IL1B TNF
25 opisthorchiasis 10.4 IL1B TNF
26 irritant dermatitis 10.3 IL1B TNF
27 haemophilus influenzae 10.3 IL1B TNF
28 ascaris lumbricoides infection 10.3 IL1B IL6
29 funisitis 10.3 IL1B IL6
30 euthyroid sick syndrome 10.3 IL1B IL6
31 uremic pruritus 10.3 IL1B IL6
32 inflammatory bowel disease 10.3
33 retinitis pigmentosa 55 10.3 IL6 TNF
34 meconium aspiration syndrome 10.3 IL6 TNF
35 burning mouth syndrome 10.3 IL6 TNF
36 null-cell leukemia 10.3 IL6 TNF
37 posterior urethral valves 10.3 IL6 TNF
38 exudative glomerulonephritis 10.3 IL1B TNF
39 microscopic colitis 10.2 HLA-DRB1 TNF
40 sympathetic ophthalmia 10.2 HLA-DRB1 TNF
41 rheumatoid vasculitis 10.2 HLA-DRB1 TNF
42 chronic beryllium disease 10.2 HLA-DRB1 TNF
43 benign childhood occipital epilepsy, gastaut type 10.2
44 rheumatoid arthritis, systemic juvenile 10.2 HLA-DRB1 IL6
45 anca-associated vasculitis 10.2 HLA-DRB1 IL6
46 staphylococcal toxic shock syndrome 10.2 IL1B TNF
47 scorpion envenomation 10.2 IL6 TNF
48 recurrent corneal erosion 10.2 IL1B IL6
49 bagassosis 10.2 IL1B IL6
50 mesial temporal lobe epilepsy with hippocampal sclerosis 10.2 HLA-DRB1 IL1B

Graphical network of the top 20 diseases related to Dengue Shock Syndrome:



Diseases related to Dengue Shock Syndrome

Symptoms & Phenotypes for Dengue Shock Syndrome

Symptoms:

12
  • easy bruising
  • bleeding gums
  • blood spots
  • nosebleeds

Drugs & Therapeutics for Dengue Shock Syndrome

Drugs for Dengue Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
2
Histamine Approved, Investigational Phase 4 51-45-6 774
3
Histamine Phosphate Phase 4 51-74-1 65513
4 Anti-Allergic Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Histamine H1 Antagonists Phase 4
7 Antipruritics Phase 4
8 Dermatologic Agents Phase 4
9 Histamine Antagonists Phase 4
10
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
11 Pharmaceutical Solutions Phase 3,Phase 2
12 Antiparasitic Agents Phase 2, Phase 3
13 Anti-Infective Agents Phase 2, Phase 3
14 Vaccines Phase 3,Phase 2,Phase 1,Not Applicable
15 Immunologic Factors Phase 3,Phase 2,Phase 1
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
17
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
18
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
19
Ribavirin Approved Phase 2 36791-04-5 37542
20
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
21 Antimetabolites Phase 2
22 Antiviral Agents Phase 2
23 Hydrocortisone 17-butyrate 21-propionate Phase 2
24 Hydrocortisone hemisuccinate Phase 2
25 Antibodies Phase 2,Phase 1,Not Applicable
26 Immunoglobulins Phase 2,Phase 1,Not Applicable
27 Antibodies, Monoclonal Phase 2
28
Aluminum sulfate Approved Phase 1 10043-01-3
29
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
30
Varespladib methyl Investigational Phase 1 172733-08-3
31 Anti-Ulcer Agents Phase 1
32 Adjuvants, Immunologic Phase 1
33 Antacids Phase 1
34 Gastrointestinal Agents Phase 1
35
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
36 gamma-Globulins Not Applicable
37 Immunoglobulins, Intravenous Not Applicable
38 Rho(D) Immune Globulin Not Applicable

Interventional clinical trials:

(show top 50) (show all 112)
# Name Status NCT ID Phase Drugs
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
2 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
3 Efficacy and Safety of Ivermectin Against Dengue Infection Unknown status NCT02045069 Phase 2, Phase 3 2 days Ivermectin;3 days Ivermectin;Placebo
4 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
5 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Completed NCT01373281 Phase 3
6 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Active, not recruiting NCT02992418 Phase 3
7 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
8 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Completed NCT01374516 Phase 3
9 Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children Active, not recruiting NCT02747927 Phase 3 TDV Placebo
10 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) at the End of Shelf Life in Healthy Adults Not yet recruiting NCT03771963 Phase 3
11 Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue Completed NCT03423173 Phase 3
12 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
13 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Active, not recruiting NCT02993757 Phase 3
14 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Active, not recruiting NCT02979535 Phase 3
15 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
16 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2 Western Medicine;TCM and Western Medicine
17 Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore Not yet recruiting NCT02569827 Phase 1, Phase 2 Celgosivir;Modipafant 50mg;Placebo;Modipafant 100mg
18 IC14 in Adult Patients With Dengue Fever Withdrawn NCT03875560 Phase 2 Placebo
19 Celgosivir as a Treatment Against Dengue Completed NCT01619969 Phase 1, Phase 2 celgosivir;placebo
20 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule Active, not recruiting NCT02824198 Phase 2
21 Immunogenicity and Safety of Different Vaccination Schedules of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age Active, not recruiting NCT02628444 Phase 2
22 Study of a Booster Dose of a Tetravalent Dengue Vaccine in Subjects Who Previously Completed the 3-dose Schedule Active, not recruiting NCT02623725 Phase 2
23 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
24 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
25 Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults Not yet recruiting NCT02741128 Phase 2
26 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
27 Immunogenicity and Safety of Tetravalent Dengue Vaccine Candidate (TDV) in Flavivirus-Naïve and Dengue-Immune Adults Recruiting NCT03746015 Phase 2
28 Safety and Immunogenicity With Two Different Serotype 2 Potencies of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Adults in Singapore Completed NCT02425098 Phase 2
29 Safety and Immunogenicity of Different Schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Healthy Participants Completed NCT02302066 Phase 2 TDV Placebo
30 Safety and Immunogenicity of Three Formulations of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) Completed NCT02193087 Phase 2 TDV Liquid Formulation 1;TDV Liquid Formulation 2;TDV IDT Lyophilized;Placebo
31 Pharmacokinetics and Pharmacodynamics of Ivermectin in Pediatric Dengue Patients Recruiting NCT03432442 Phase 2 Ivermectin
32 A Phase I/II Trial of a Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naïve Children Completed NCT00384670 Phase 1, Phase 2
33 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
34 A Study of Two Doses of WRAIR Dengue Vaccine Administered Six Months Apart to Healthy Adults and Children Completed NCT00468858 Phase 2
35 Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine Completed NCT01943825 Phase 2
36 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
37 Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects Completed NCT00730288 Phase 2
38 Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine Completed NCT01488890 Phase 2
39 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed NCT00880893 Phase 2
40 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
41 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed NCT00842530 Phase 2
42 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed NCT00788151 Phase 2
43 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed NCT00993447 Phase 2
44 A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants Completed NCT00322049 Phase 1, Phase 2
45 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Active, not recruiting NCT03110770 Phase 2
46 Study to Investigate the Safety and Immunogenicity of a Tetravalent Chimeric Dengue Vaccine in Healthy Volunteers Between the Ages of 1.5 - 45 Years Completed NCT01511250 Phase 2
47 A Study of Balapiravir in Patients With Dengue Virus Infection Completed NCT01096576 Phase 1 balapiravir [RO4588161];placebo
48 Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever Completed NCT01224639 Phase 1
49 Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus Completed NCT00458120 Phase 1
50 Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3delta30/31‐7164) in Healthy Adults Completed NCT00831012 Phase 1

Search NIH Clinical Center for Dengue Shock Syndrome

Genetic Tests for Dengue Shock Syndrome

Anatomical Context for Dengue Shock Syndrome

MalaCards organs/tissues related to Dengue Shock Syndrome:

42
Colon, T Cells, Endothelial, Testes, Liver, Neutrophil, Myeloid

Publications for Dengue Shock Syndrome

Articles related to Dengue Shock Syndrome:

(show top 50) (show all 678)
# Title Authors Year
1
Electroacupuncture and Moxibustion Improved Anxiety Behavior in DSS-Induced Colitis Mice. ( 30881446 )
2019
2
The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis. ( 30915354 )
2019
3
Purification of 3, 4-dihydroxyphenylethyl alcohol glycoside from Sargentodoxa cuneata (Oliv.) Rehd. et Wils. and its protective effects against DSS-induced colitis. ( 30824734 )
2019
4
Tripterygium glycoside fraction n2: Alleviation of DSS-induced colitis by modulating immune homeostasis in mice. ( 30851581 )
2019
5
Peanut shell extract inhibits the development of dextran sulfate sodium (DSS)-induced colitis. ( 30851703 )
2019
6
Protective effect of three glucomannans from different plants against DSS induced colitis in female BALB/c mice. ( 30869676 )
2019
7
Three types of gut bacteria collaborating to improve Kui Jie'an enema treat DSS-induced colitis in mice. ( 30870717 )
2019
8
Antioxidant Activity of Yogurt Fermented at Low Temperature and Its Anti-inflammatory Effect on DSS-induced Colitis in Mice. ( 30882084 )
2019
9
Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling. ( 30901677 )
2019
10
MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota. ( 30738250 )
2019
11
Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats. ( 30743078 )
2019
12
Disease development is accompanied by changes in bacterial protein abundance and functions in a refined model of dextran sulfate sodium (DSS)-induced colitis. ( 30767541 )
2019
13
Mulberry juice freeze-dried powder attenuates the disease severity by the maintaining of colon mucosa in mice with DSS-induced acute colitis. ( 30774006 )
2019
14
Alginate/chitosan microcapsules for in-situ delivery of the protein, Interleukin-1 Receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. ( 30779979 )
2019
15
A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation. ( 30806428 )
2019
16
Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells. ( 30814921 )
2019
17
Effect of compound sophorae decoction on dextran sodium sulfate (DSS)-induced colitis in mice by regulating Th17/Treg cell balance. ( 30551499 )
2019
18
Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model. ( 30569176 )
2019
19
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1. ( 30610999 )
2019
20
Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis. ( 30442521 )
2019
21
Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer. ( 30551398 )
2019
22
Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice. ( 30530259 )
2019
23
ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation. ( 30701287 )
2019
24
Cross-Linking Antibodies to Beads with Disuccinimidyl Suberate (DSS). ( 30710026 )
2019
25
The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in Nod2 knockout mice. ( 30774010 )
2019
26
Response planning for accidental oil spills in Persian Gulf: A decision support system (DSS) based on consequence modeling. ( 30803625 )
2019
27
Salivary Glycine Is a Significant Predictor for the Attenuation of Polyp and Tumor Microenvironment Formation by Fucoxanthin in AOM/DSS Mice. ( 30804114 )
2019
28
DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking. ( 30837285 )
2019
29
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome. ( 29447178 )
2018
30
Dengue shock syndrome complicated with acute liver failure and kidney injury, infective endocarditis, and deep vein thrombosis: a case report. ( 30373645 )
2018
31
Inhibition of ASM activity ameliorates DSS-induced colitis in mice. ( 30550872 )
2018
32
Vascular endothelial growth factor receptor 1 tyrosine kinase signaling facilitates healing of DSS-induced colitis by accumulation of Tregs in ulcer area. ( 30579252 )
2018
33
SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression. ( 30585268 )
2018
34
Active Vaccination With EMMPRIN-Derived Multiple Antigenic Peptide (161-MAP) Reduces Angiogenesis in a Dextran Sodium Sulfate (DSS)-Induced Colitis Model. ( 30619283 )
2018
35
The anti-inflammatory activity of peptides from simulated gastrointestinal digestion of preserved egg white in DSS-induced mouse colitis. ( 30462121 )
2018
36
Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice. ( 30472831 )
2018
37
Maternal High Fat Diet Alters Gut Microbiota of Offspring and Exacerbates DSS-Induced Colitis in Adulthood. ( 30483266 )
2018
38
Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation. ( 30496979 )
2018
39
Corrigendum to "3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1, 2, 4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation". ( 30510629 )
2018
40
5-Hydroxytryptamine (5-HT)-exacerbated DSS-induced colitis is associated with elevated NADPH oxidase expression in the colon. ( 30525222 )
2018
41
PGlyRP3 concerts with PPARγ to attenuate DSS-induced colitis in mice. ( 30530168 )
2018
42
IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response. ( 30539029 )
2018
43
Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production. ( 30396035 )
2018
44
Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice. ( 30453939 )
2018
45
Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model. ( 30284461 )
2018
46
Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis. ( 30297787 )
2018
47
Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice. ( 30312415 )
2018
48
Inhibition of NADPH oxidase activities ameliorates DSS-induced colitis. ( 30321511 )
2018
49
iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis. ( 30333822 )
2018
50
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism. ( 30355787 )
2018

Variations for Dengue Shock Syndrome

Expression for Dengue Shock Syndrome

Search GEO for disease gene expression data for Dengue Shock Syndrome.

Pathways for Dengue Shock Syndrome

Pathways related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CCL2 HLA-A HLA-DRB1 IL1B IL1RN IL6
2
Show member pathways
12.88 CCL2 HLA-A IL1B IL6 MICB TNF
3
Show member pathways
12.81 HLA-A HLA-DRB1 IL1B IL6 TNF
4
Show member pathways
12.53 HLA-DRB1 IL1B IL6 TNF
5
Show member pathways
12.52 CCL2 IL1B IL6 TNF
6 12.49 CCL2 IL1B IL1RN TNF
7
Show member pathways
12.45 CCL2 HLA-A HLA-DRB1 IL1B IL6 TNF
8 12.3 HLA-A HLA-DRB1 IL6 TNF
9
Show member pathways
12.29 CCL2 IL1B IL6 TNF
10
Show member pathways
12.28 CCL2 IL1B IL6 TNF
11
Show member pathways
12.2 HLA-A IL1B IL6 TNF
12 12.19 HLA-DRB1 IL1B IL6 TNF
13
Show member pathways
12.17 IL1B IL1RN IL6 TNF
14 12.13 IL1B IL1RN IL6 TNF
15
Show member pathways
12.1 IL1B IL6 TNF
16 12.02 CCL2 IL1B THBD TNF
17
Show member pathways
11.99 IL1B IL6 TNF
18
Show member pathways
11.97 IL1B IL6 TNF
19 11.93 CCL2 IL1B IL6 TNF
20
Show member pathways
11.92 HLA-A HLA-DRB1 IL1B
21 11.89 CCL2 IL1B IL6 TNF
22 11.87 CCL2 IL1B IL6 TNF
23
Show member pathways
11.85 CMA1 TNF TPSAB1
24 11.83 IL1B IL6 TNF
25 11.8 HLA-DRB1 IL1B IL6 TNF
26 11.72 IL1B IL6 TNF
27 11.68 CCL2 HLA-DRB1 IL1B IL6 TNF
28
Show member pathways
11.63 IL1B IL6 TNF
29 11.63 IL1B IL6 THBD TNF
30 11.56 IL1B IL6 TNF
31 11.51 CCL2 IL1B IL1RN IL6 TNF
32 11.49 CCL2 IL1B TNF
33 11.46 IL1B IL6 TNF
34 11.4 CCL2 IL1B IL6 TNF
35 11.35 CCL2 CMA1 IL1B IL6 TNF
36 11.34 IL1B IL6 TNF
37 11.31 IL1B IL6 TNF
38 11.29 CCL2 IL6 THBD
39 11.25 IL1B IL6 TNF
40 11.23 IL1B IL6 TNF
41 11.13 HLA-DRB1 IL1B IL6 TNF
42 11.11 CCL2 IL1B
43 11.1 CCL2 IL1B IL6 PLCE1 THBD TNF
44 11.06 CCL2 IL1B IL6 PLCE1 TNF
45 11.05 IL1B TNF
46 11.04 IL6 TNF
47 11.04 CCL2 IL1B IL1RN IL6 TNF
48 10.98 IL6 TNF
49 10.96 CCL2 IL1B IL6 PLCE1 TNF
50 10.86 CCL2 IL1B TNF

GO Terms for Dengue Shock Syndrome

Cellular components related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL2 CMA1 IL1B IL1RN IL6 TNF
2 cell surface GO:0009986 9.35 HLA-A HLA-DRB1 MICB THBD TNF
3 extracellular space GO:0005615 9.23 CCL2 CMA1 IL1B IL1RN IL6 THBD

Biological processes related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.96 CCL2 IL1B IL1RN IL6 TNF
2 inflammatory response GO:0006954 9.89 CCL2 IL1B IL1RN IL6 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.83 CCL2 IL1B IL1RN IL6 TNF
5 activation of MAPK activity GO:0000187 9.81 IL1B PLCE1 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF
7 neutrophil chemotaxis GO:0030593 9.8 CCL2 IL1B IL1RN
8 positive regulation of JNK cascade GO:0046330 9.79 IL1B IL1RN TNF
9 cellular response to organic cyclic compound GO:0071407 9.77 CCL2 IL1B TNF
10 humoral immune response GO:0006959 9.76 CCL2 IL6 TNF
11 protein kinase B signaling GO:0043491 9.69 CCL2 IL1B TNF
12 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
13 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
14 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B TNF
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 CCL2 IL1B TNF
16 cellular response to lipopolysaccharide GO:0071222 9.65 CCL2 IL1B IL1RN IL6 TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
19 negative regulation of neurogenesis GO:0050768 9.63 IL1B IL6 TNF
20 positive regulation of interleukin-6 production GO:0032755 9.62 IL1B IL1RN IL6 TNF
21 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
22 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
23 regulation of establishment of endothelial barrier GO:1903140 9.59 IL1B TNF
24 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.58 IL1RN IL6
25 positive regulation of glial cell proliferation GO:0060252 9.58 IL1B IL6 TNF
26 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
27 sequestering of triglyceride GO:0030730 9.55 IL1B TNF
28 response to glucocorticoid GO:0051384 9.54 IL1RN IL6 TNF
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IL1B TNF
30 positive regulation of neuroinflammatory response GO:0150078 9.33 IL1B IL6 TNF
31 positive regulation of JUN kinase activity GO:0043507 9.24 TNF
32 immune response GO:0006955 9.23 CCL2 HLA-A HLA-DRB1 IL1B IL1RN IL6
33 chronic inflammatory response to antigenic stimulus GO:0002439 8.65 TNF

Molecular functions related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 IL1B IL1RN IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Dengue Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
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38 KEGG
39 LifeMap
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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