Aliases & Classifications for Dense Deposit Disease

MalaCards integrated aliases for Dense Deposit Disease:

Name: Dense Deposit Disease 53
Mesangiocapillary Glomerulonephritis, Type Ii 29 6
Membranoproliferative Glomerulonephritis, Type Ii 73
Membranoproliferative Glomerulonephritis Type Ii 53
Glomerulonephritis Membranoproliferative Type 2 53
Membranoproliferative Glomerulonephritis Type 2 53
Mesangiocapillary Glomerulonephritis Type 2 53
Mpgn 2 53
Ddd 53

Classifications:



External Ids:

UMLS 73 C0268743

Summaries for Dense Deposit Disease

NIH Rare Diseases : 53 Dense deposit disease (DDD) is a condition that primarily affects kidney function. Signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. The major features of DDD are due to kidney malfunction, and often include proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. About half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start. DDD can have genetic or non-genetic causes. It can be caused by mutations in the C3 and CFH genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. Most cases are sporadic (occurring by chance in people with no history of the disorder in their family).

MalaCards based summary : Dense Deposit Disease, also known as mesangiocapillary glomerulonephritis, type ii, is related to c3 glomerulopathy and glomerulonephritis. An important gene associated with Dense Deposit Disease is DGKE (Diacylglycerol Kinase Epsilon), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. The drugs Immunoglobulin A and Antigen-Antibody Complex have been mentioned in the context of this disorder. Affiliated tissues include kidney and breast, and related phenotype is renal/urinary system.

Wikipedia : 76 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

Related Diseases for Dense Deposit Disease

Diseases related to Dense Deposit Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 c3 glomerulopathy 31.1 C3 CFB CFHR5
2 glomerulonephritis 29.9 C3 CFH CFHR5
3 membranoproliferative glomerulonephritis 28.4 C3 CFB CFH CFHR5
4 macular degeneration, age-related, 1 27.6 C3 CFB CFH CFHR5
5 dowling-degos disease 1 11.9
6 complement factor h deficiency 11.7
7 degenerative disc disease 11.4
8 dowling-degos disease 11.3
9 dowling-degos disease 2 11.1
10 glomerulopathy with fibronectin deposits 2 10.2
11 fibrillary glomerulonephritis 10.2
12 immunotactoid glomerulopathy 10.2
13 collagen type iii glomerulopathy 10.2
14 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 10.1
15 nephrotic syndrome, type 7 10.1 CFH DGKE
16 proliferative glomerulonephritis 10.0 C3 CFH
17 familial partial lipodystrophy 10.0
18 lyme disease 9.9 C3 CFH
19 crescentic glomerulonephritis 9.9
20 complement deficiency 9.8 C3 C5
21 aging 9.7
22 acute kidney failure 9.7
23 nephrotic syndrome 9.7
24 pneumonia 9.7
25 kidney disease 9.7
26 monoclonal gammopathy of uncertain significance 9.7
27 vasculitis 9.7
28 amyloidosis 9.7
29 mycoplasmal pneumonia 9.7
30 streptococcal group a invasive disease 9.7
31 complement component 3 deficiency 9.7 C3 CFB
32 multifocal choroiditis 9.7 CFB CFH
33 choroiditis 9.7 CFB CFH
34 kuhnt-junius degeneration 9.6 CFB CFH
35 hemoglobinuria 9.6 C3 C5
36 hemolytic uremic syndrome, atypical 1 9.5 CFH CFHR5 DGKE
37 retinal drusen 9.3 C3 CFB CFH
38 degeneration of macula and posterior pole 9.3 C3 CFB CFH
39 retinal disease 9.1 CFB CFH
40 enterocolitis 8.7 C3 CFB CFH CFHR5
41 hemolytic-uremic syndrome 6.9 C3 C5 CFB CFH CFHR2 CFHR5

Graphical network of the top 20 diseases related to Dense Deposit Disease:



Diseases related to Dense Deposit Disease

Symptoms & Phenotypes for Dense Deposit Disease

MGI Mouse Phenotypes related to Dense Deposit Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 C3 C5 CFB CFH

Drugs & Therapeutics for Dense Deposit Disease

Drugs for Dense Deposit Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin A Phase 2
2 Antigen-Antibody Complex Phase 2
3
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
4 Angiotensin-Converting Enzyme Inhibitors Phase 1
5 Vaccines Phase 1
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721 Recruiting NCT02682407 Phase 2
2 Phase II Study Assessing Safety and Efficacy of APL-2 in Glomerulopathies Recruiting NCT03453619 Phase 2 APL-2
3 A Proof of Concept Study for 6 Month Treatment in Patients With C3 Glomerulopathy (C3G) Recruiting NCT03369236 Phase 2 ACH-0144471;Placebo
4 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
5 A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Recruiting NCT03459443 Phase 2 ACH-0144471
6 Controlled Trial Evaluating Avacopan in C3 Glomerulopathy Recruiting NCT03301467 Phase 2 Avacopan;Avacopan Matching Placebo
7 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1 Eculizumab
8 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1 CDX-1135
9 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1 Sulodexide
10 TP10 Use in Patients With C3 Glomerulopathy (C3G) Withdrawn NCT02302755 Phase 1 TP10

Search NIH Clinical Center for Dense Deposit Disease

Genetic Tests for Dense Deposit Disease

Genetic tests related to Dense Deposit Disease:

# Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis, Type Ii 29 DGKE

Anatomical Context for Dense Deposit Disease

MalaCards organs/tissues related to Dense Deposit Disease:

41
Kidney, Breast

Publications for Dense Deposit Disease

Articles related to Dense Deposit Disease:

(show top 50) (show all 51)
# Title Authors Year
1
Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report. ( 29724182 )
2018
2
C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy. ( 29310824 )
2018
3
Dense Deposit Disease Involving C3 and C4d Deposits. ( 29515303 )
2018
4
Cloudy Cornea with Arcus Juvenilis in a Case of Dense Deposit Disease. ( 29950499 )
2018
5
Treatment with bortezomib in dense deposit disease associated with monoclonal gammopathy of undetermined significance. ( 29363742 )
2018
6
Dense deposit disease in a child with febrile sore throat. ( 28748900 )
2017
7
Dense deposit disease associated with multiple myelomaa8c. ( 29208205 )
2017
8
Discontinuation of dialysis with eculizumab therapy in a pediatric patient with dense deposit disease. ( 26759144 )
2016
9
Proliferative C4 Dense Deposit Disease, Acute ThromboticA Microangiopathy, a Monoclonal Gammopathy, andA Acute Kidney Failure. ( 26704376 )
2016
10
Dense Deposit Disease Mimicking a Renal Small Vessel Vasculitis. ( 26361799 )
2015
11
Eculizumab in Pediatric Dense Deposit Disease. ( 26316621 )
2015
12
Overlap of ultrastructural findings in C3 glomerulonephritis and dense deposit disease. ( 26649668 )
2015
13
AJKD Atlas of Renal Pathology: Dense Deposit Disease. ( 26300205 )
2015
14
C4 dense-deposit disease. ( 24552345 )
2014
15
Streptococcal infection as possible trigger for dense deposit disease (C3 glomerulopathy). ( 24384791 )
2014
16
Heterogeneous histologic and clinical evolution in 3 cases of dense deposit disease with long-term follow-up. ( 25260719 )
2014
17
Eculizumab in dense-deposit disease after renal transplantation. ( 24908321 )
2014
18
C3 glomerulopathy: the genetic and clinical findings in dense deposit disease and C3 glomerulonephritis. ( 24799308 )
2014
19
Eculizumab therapy in a patient with dense-deposit disease associated with partial lipodystropy. ( 24464478 )
2014
20
Blockade of alternative complement pathway in dense deposit disease. ( 24672732 )
2014
21
Dense deposit disease in an elderly patient: report of a case. ( 24998957 )
2014
22
Complement factor H-related hybrid protein deregulates complement in dense deposit disease. ( 24334459 )
2014
23
Dense deposit disease: a 29-years electron microscopy experience. ( 24053741 )
2013
24
Alternative pathway dysfunction in kidney disease: a case report and review of dense deposit disease and C3 glomerulopathy. ( 23391537 )
2013
25
Dense Deposit Disease: A Rare Cause of Steroid Resistant Nephrotic Syndrome. ( 23783769 )
2013
26
Dense deposit disease and C3 glomerulopathy. ( 24161036 )
2013
27
Childhood-onset dense deposit disease: a rare cause of proteinuria. ( 24338037 )
2013
28
Eculizumab for dense deposit disease and C3 glomerulonephritis. ( 22403278 )
2012
29
Dense deposit disease in Korean children: a multicenter clinicopathologic study. ( 23091320 )
2012
30
Pathology after eculizumab in dense deposit disease and C3 GN. ( 22677550 )
2012
31
Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. ( 22456601 )
2012
32
Clinical and pathological features of dense deposit disease in Chinese patients. ( 22874109 )
2012
33
Eculizumab in a patient with dense-deposit disease. ( 22435382 )
2012
34
Eculizumab for the treatment of dense-deposit disease. ( 22435383 )
2012
35
Experimental models of membranoproliferative glomerulonephritis, including dense deposit disease. ( 21252520 )
2011
36
A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency. ( 20221776 )
2010
37
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. ( 20852386 )
2010
38
Anti-factor B autoantibody in dense deposit disease. ( 20193965 )
2010
39
Dense deposit disease is not a membranoproliferative glomerulonephritis. ( 17396142 )
2007
40
Membranoproliferative glomerulonephritis type II (dense deposit disease) in association with monoclonal gammopathy. ( 17635761 )
2007
41
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). ( 16299065 )
2006
42
Deletion of Lys224 in regulatory domain 4 of factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). ( 16612335 )
2006
43
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. ( 15800116 )
2005
44
Crescentic glomerulonephritis and dense deposit disease in a woman with breast carcinoma on immunosuppressive chemotherapy. ( 15332237 )
2004
45
Crescentic glomerulonephritis in childhood: acute nonproliferative glomerulitis versus dense deposit disease. ( 12666078 )
2003
46
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. ( 10783137 )
2000
47
Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). ( 8238252 )
1993
48
Porcine membranoproliferative glomerulonephritis with intramembranous dense deposits (porcine dense deposit disease). ( 8323737 )
1993
49
Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II ( 20301598 )
1993
50
Regression of membranoproliferative glomerulonephritis type II (dense deposit disease): observations in six children. ( 3400634 )
1988

Variations for Dense Deposit Disease

ClinVar genetic disease variations for Dense Deposit Disease:

6
(show top 50) (show all 182)
# Gene Variation Type Significance SNP ID Assembly Location
1 CFHR5 NM_030787.3(CFHR5): c.622T> C (p.Cys208Arg) single nucleotide variant Uncertain significance rs41299613 GRCh37 Chromosome 1, 196964861: 196964861
2 CFHR5 NM_030787.3(CFHR5): c.622T> C (p.Cys208Arg) single nucleotide variant Uncertain significance rs41299613 GRCh38 Chromosome 1, 196995731: 196995731
3 CFH NM_000186.3(CFH): c.3176T> C (p.Ile1059Thr) single nucleotide variant Benign/Likely benign rs35343172 GRCh37 Chromosome 1, 196712624: 196712624
4 CFH NM_000186.3(CFH): c.3176T> C (p.Ile1059Thr) single nucleotide variant Benign/Likely benign rs35343172 GRCh38 Chromosome 1, 196743494: 196743494
5 CFH NM_000186.3(CFH): c.-195T> C single nucleotide variant Benign rs35836460 GRCh38 Chromosome 1, 196651923: 196651923
6 CFH NM_000186.3(CFH): c.-195T> C single nucleotide variant Benign rs35836460 GRCh37 Chromosome 1, 196621053: 196621053
7 CFH NM_000186.3(CFH): c.-61A> G single nucleotide variant Uncertain significance rs886045741 GRCh38 Chromosome 1, 196652057: 196652057
8 CFH NM_000186.3(CFH): c.-61A> G single nucleotide variant Uncertain significance rs886045741 GRCh37 Chromosome 1, 196621187: 196621187
9 CFH NM_000186.3(CFH): c.428-3C> T single nucleotide variant Uncertain significance rs886045744 GRCh38 Chromosome 1, 196677473: 196677473
10 CFH NM_000186.3(CFH): c.428-3C> T single nucleotide variant Uncertain significance rs886045744 GRCh37 Chromosome 1, 196646603: 196646603
11 CFH NM_000186.3(CFH): c.1949G> T (p.Gly650Val) single nucleotide variant Likely benign rs143237092 GRCh37 Chromosome 1, 196695675: 196695675
12 CFH NM_000186.3(CFH): c.1949G> T (p.Gly650Val) single nucleotide variant Likely benign rs143237092 GRCh38 Chromosome 1, 196726545: 196726545
13 CFH NM_000186.3(CFH): c.2016A> G (p.Gln672=) single nucleotide variant Benign rs3753396 GRCh37 Chromosome 1, 196695742: 196695742
14 CFH NM_000186.3(CFH): c.2016A> G (p.Gln672=) single nucleotide variant Benign rs3753396 GRCh38 Chromosome 1, 196726612: 196726612
15 CFH NM_000186.3(CFH): c.2236+8T> A single nucleotide variant Likely benign rs7537967 GRCh37 Chromosome 1, 196696078: 196696078
16 CFH NM_000186.3(CFH): c.2236+8T> A single nucleotide variant Likely benign rs7537967 GRCh38 Chromosome 1, 196726948: 196726948
17 CFH NM_000186.3(CFH): c.2808G> T (p.Glu936Asp) single nucleotide variant Benign rs1065489 GRCh37 Chromosome 1, 196709774: 196709774
18 CFH NM_000186.3(CFH): c.2808G> T (p.Glu936Asp) single nucleotide variant Benign rs1065489 GRCh38 Chromosome 1, 196740644: 196740644
19 CFH NM_000186.3(CFH): c.-175T> C single nucleotide variant Uncertain significance rs762143457 GRCh38 Chromosome 1, 196651943: 196651943
20 CFH NM_000186.3(CFH): c.-175T> C single nucleotide variant Uncertain significance rs762143457 GRCh37 Chromosome 1, 196621073: 196621073
21 CFH NM_000186.3(CFH): c.3050C> T (p.Thr1017Ile) single nucleotide variant Likely benign rs34362004 GRCh37 Chromosome 1, 196711098: 196711098
22 CFH NM_000186.3(CFH): c.3050C> T (p.Thr1017Ile) single nucleotide variant Likely benign rs34362004 GRCh38 Chromosome 1, 196741968: 196741968
23 CFH NM_000186.3(CFH): c.3133+8G> T single nucleotide variant Likely benign rs142718541 GRCh38 Chromosome 1, 196742059: 196742059
24 CFH NM_000186.3(CFH): c.3133+8G> T single nucleotide variant Likely benign rs142718541 GRCh37 Chromosome 1, 196711189: 196711189
25 CFH NM_000186.3(CFH): c.-79A> G single nucleotide variant Likely benign rs35906110 GRCh38 Chromosome 1, 196652039: 196652039
26 CFH NM_000186.3(CFH): c.-79A> G single nucleotide variant Likely benign rs35906110 GRCh37 Chromosome 1, 196621169: 196621169
27 CFH NM_000186.3(CFH): c.-36G> C single nucleotide variant Likely benign rs140356702 GRCh38 Chromosome 1, 196652082: 196652082
28 CFH NM_000186.3(CFH): c.-36G> C single nucleotide variant Likely benign rs140356702 GRCh37 Chromosome 1, 196621212: 196621212
29 CFH NM_000186.3(CFH): c.275C> T (p.Pro92Leu) single nucleotide variant Uncertain significance rs886045743 GRCh38 Chromosome 1, 196673887: 196673887
30 CFH NM_000186.3(CFH): c.275C> T (p.Pro92Leu) single nucleotide variant Uncertain significance rs886045743 GRCh37 Chromosome 1, 196643017: 196643017
31 CFH NM_000186.3(CFH): c.285T> C (p.Thr95=) single nucleotide variant Uncertain significance rs148182625 GRCh38 Chromosome 1, 196673897: 196673897
32 CFH NM_000186.3(CFH): c.285T> C (p.Thr95=) single nucleotide variant Uncertain significance rs148182625 GRCh37 Chromosome 1, 196643027: 196643027
33 CFH NM_000186.3(CFH): c.1160-15T> C single nucleotide variant Benign rs34815383 GRCh38 Chromosome 1, 196690048: 196690048
34 CFH NM_000186.3(CFH): c.1160-15T> C single nucleotide variant Benign rs34815383 GRCh37 Chromosome 1, 196659178: 196659178
35 CFH NM_000186.3(CFH): c.3207T> C (p.Ser1069=) single nucleotide variant Likely benign rs62641697 GRCh38 Chromosome 1, 196743525: 196743525
36 CFH NM_000186.3(CFH): c.3207T> C (p.Ser1069=) single nucleotide variant Likely benign rs62641697 GRCh37 Chromosome 1, 196712655: 196712655
37 CFH NM_000186.3(CFH): c.1204C> T (p.His402Tyr) single nucleotide variant Benign rs1061170 GRCh38 Chromosome 1, 196690107: 196690107
38 CFH NM_000186.3(CFH): c.1204C> T (p.His402Tyr) single nucleotide variant Benign rs1061170 GRCh37 Chromosome 1, 196659237: 196659237
39 CFH NM_000186.3(CFH): c.1428A> G (p.Gln476=) single nucleotide variant Likely benign rs34399588 GRCh38 Chromosome 1, 196713826: 196713826
40 CFH NM_000186.3(CFH): c.1428A> G (p.Gln476=) single nucleotide variant Likely benign rs34399588 GRCh37 Chromosome 1, 196682956: 196682956
41 CFH NM_000186.3(CFH): c.3310+12T> C single nucleotide variant Uncertain significance rs757045842 GRCh38 Chromosome 1, 196743640: 196743640
42 CFH NM_000186.3(CFH): c.3310+12T> C single nucleotide variant Uncertain significance rs757045842 GRCh37 Chromosome 1, 196712770: 196712770
43 CFH NM_000186.3(CFH): c.3427C> G (p.Gln1143Glu) single nucleotide variant Benign rs15809 GRCh38 Chromosome 1, 196745933: 196745933
44 CFH NM_000186.3(CFH): c.3427C> G (p.Gln1143Glu) single nucleotide variant Benign rs15809 GRCh37 Chromosome 1, 196715063: 196715063
45 CFH NM_000186.3(CFH): c.1548T> A (p.Asn516Lys) single nucleotide variant Likely benign rs147403664 GRCh38 Chromosome 1, 196715621: 196715621
46 CFH NM_000186.3(CFH): c.1548T> A (p.Asn516Lys) single nucleotide variant Likely benign rs147403664 GRCh37 Chromosome 1, 196684751: 196684751
47 CFH NM_000186.3(CFH): c.2542G> A (p.Gly848Arg) single nucleotide variant Uncertain significance rs886045746 GRCh37 Chromosome 1, 196706082: 196706082
48 CFH NM_000186.3(CFH): c.2542G> A (p.Gly848Arg) single nucleotide variant Uncertain significance rs886045746 GRCh38 Chromosome 1, 196736952: 196736952
49 CFH NM_000186.3(CFH): c.2784C> A (p.Gly928=) single nucleotide variant Uncertain significance rs755926856 GRCh37 Chromosome 1, 196709750: 196709750
50 CFH NM_000186.3(CFH): c.2784C> A (p.Gly928=) single nucleotide variant Uncertain significance rs755926856 GRCh38 Chromosome 1, 196740620: 196740620

Expression for Dense Deposit Disease

Search GEO for disease gene expression data for Dense Deposit Disease.

Pathways for Dense Deposit Disease

GO Terms for Dense Deposit Disease

Cellular components related to Dense Deposit Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.33 C3 CFHR2 CFHR5
2 blood microparticle GO:0072562 9.13 C3 CFB CFH
3 extracellular region GO:0005576 9.1 C3 C5 CFB CFH CFHR2 CFHR5

Biological processes related to Dense Deposit Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.62 C3 C5 CFB CFH
2 immune system process GO:0002376 9.61 C3 C5 CFB
3 negative regulation of endopeptidase activity GO:0010951 9.46 C3 C5
4 complement activation GO:0006956 9.46 C3 C5 CFB CFH
5 regulation of complement activation GO:0030449 9.43 C3 C5 CFB CFH CFHR2 CFHR5
6 negative regulation of protein binding GO:0032091 9.4 CFHR2 CFHR5
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.37 C3 C5
8 positive regulation of cytolysis GO:0045919 9.26 CFHR2 CFHR5
9 complement activation, alternative pathway GO:0006957 9.02 C3 C5 CFB CFH CFHR5

Molecular functions related to Dense Deposit Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C3 C5

Sources for Dense Deposit Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....