DDD
MCID: DNS007
MIFTS: 39

Dense Deposit Disease (DDD)

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Dense Deposit Disease

MalaCards integrated aliases for Dense Deposit Disease:

Name: Dense Deposit Disease 53
Mesangiocapillary Glomerulonephritis, Type Ii 29 6
Membranoproliferative Glomerulonephritis, Type Ii 73
Membranoproliferative Glomerulonephritis Type Ii 53
Glomerulonephritis Membranoproliferative Type 2 53
Membranoproliferative Glomerulonephritis Type 2 53
Mesangiocapillary Glomerulonephritis Type 2 53
Mpgn 2 53
Ddd 53

Classifications:



External Ids:

UMLS 73 C0268743

Summaries for Dense Deposit Disease

NIH Rare Diseases : 53 Dense deposit disease (DDD) is a condition that primarily affects kidney function. Signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. The major features of DDD are due to kidney malfunction, and often include proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. About half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start. DDD can have genetic or non-genetic causes. It can be caused by mutations in the C3 and CFH genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. Most cases are sporadic (occurring by chance in people with no history of the disorder in their family).

MalaCards based summary : Dense Deposit Disease, also known as mesangiocapillary glomerulonephritis, type ii, is related to c3 glomerulopathy and glomerulonephritis. An important gene associated with Dense Deposit Disease is DGKE (Diacylglycerol Kinase Epsilon), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. The drugs Immunoglobulin A and Complement System Proteins have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and breast, and related phenotype is renal/urinary system.

Wikipedia : 76 Membranoproliferative glomerulonephritis ("MPGN"), also known as mesangiocapillary glomerulonephritis,... more...

Related Diseases for Dense Deposit Disease

Diseases related to Dense Deposit Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 c3 glomerulopathy 32.2 C3 CFB CFHR5
2 glomerulonephritis 30.6 C3 CFH CFHR5
3 membranoproliferative glomerulonephritis 30.1 C3 CFB CFH CFHR5
4 macular degeneration, age-related, 1 29.2 C3 CFB CFH CFHR5
5 systemic lupus erythematosus 29.0 C3 C5 CFB CFH
6 dowling-degos disease 1 12.0
7 complement factor h deficiency 11.9
8 degenerative disc disease 11.5
9 dowling-degos disease 11.4
10 dowling-degos disease 2 11.3
11 acne inversa, familial, 2, with or without dowling-degos disease 11.0
12 atrioventricular block 10.4
13 glomerulopathy with fibronectin deposits 2 10.4
14 fibrillary glomerulonephritis 10.4
15 immunotactoid glomerulopathy 10.4
16 collagen type iii glomerulopathy 10.4
17 adrenocortical carcinoma, hereditary 10.3
18 sick sinus syndrome 10.3
19 adrenal cortical adenocarcinoma 10.3
20 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 10.2
21 atrial standstill 1 10.2
22 adrenal carcinoma 10.1
23 proliferative glomerulonephritis 10.1 C3 CFH
24 familial partial lipodystrophy 10.1
25 malignant atrophic papulosis 10.0
26 atrial fibrillation 10.0
27 crescentic glomerulonephritis 10.0
28 kidney disease 10.0
29 monoclonal gammopathy of uncertain significance 10.0
30 hepatitis 10.0
31 niemann-pick disease 10.0
32 hepatitis c 10.0
33 cryoglobulinemia 10.0
34 nephrotic syndrome, type 7 10.0 CFH DGKE
35 lyme disease 10.0 C3 CFH
36 multifocal choroiditis 10.0 CFB CFH
37 choroiditis 10.0 CFB CFH
38 kuhnt-junius degeneration 9.9 CFB CFH
39 lung cancer 9.9
40 myocardial infarction 9.9
41 malignant leydig cell tumor 9.9
42 renal hypertension 9.9
43 colon adenocarcinoma 9.9
44 leydig cell tumor 9.9
45 pulmonary tuberculosis 9.9
46 adenocarcinoma 9.9
47 inferior myocardial infarction 9.9
48 drug dependence 9.9
49 syncope 9.9
50 pneumococcal meningitis 9.9 C3 C5

Graphical network of the top 20 diseases related to Dense Deposit Disease:



Diseases related to Dense Deposit Disease

Symptoms & Phenotypes for Dense Deposit Disease

MGI Mouse Phenotypes related to Dense Deposit Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 C3 C5 CFB CFH

Drugs & Therapeutics for Dense Deposit Disease

Drugs for Dense Deposit Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin A Phase 2
2 Complement System Proteins Phase 2,Phase 1
3 Complement C3 Phase 2
4 Antigen-Antibody Complex Phase 2,Not Applicable
5 Antibodies Phase 2,Not Applicable
6 Immunoglobulins Phase 2,Not Applicable
7 Immunologic Factors Phase 2,Not Applicable
8
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
9 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
10 Vaccines Phase 1
11 Angiotensin-Converting Enzyme Inhibitors Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721 Recruiting NCT02682407 Phase 2
2 Phase II Study Assessing Safety and Efficacy of APL-2 in Glomerulopathies Recruiting NCT03453619 Phase 2 APL-2
3 A Proof of Concept Study for 6 Month Treatment in Patients With C3 Glomerulopathy (C3G) Recruiting NCT03369236 Phase 2 ACH-0144471;Placebo
4 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
5 A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Recruiting NCT03459443 Phase 2 ACH-0144471
6 Controlled Trial Evaluating Avacopan in C3 Glomerulopathy Recruiting NCT03301467 Phase 2 Avacopan;Avacopan Matching Placebo
7 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1 Eculizumab
8 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1 CDX-1135
9 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1 Sulodexide
10 TP10 Use in Patients With C3 Glomerulopathy (C3G) Withdrawn NCT02302755 Phase 1 TP10
11 Non-contrast Enhanced MRI in Patients With C3 Glomerulopathy (C3G) or Immune-complex Membranoproliferative Glomerulonephritis (IC-MPGN) Enrolled in the ACH471-205 Study Not yet recruiting NCT03723512 Not Applicable

Search NIH Clinical Center for Dense Deposit Disease

Genetic Tests for Dense Deposit Disease

Genetic tests related to Dense Deposit Disease:

# Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis, Type Ii 29 DGKE

Anatomical Context for Dense Deposit Disease

MalaCards organs/tissues related to Dense Deposit Disease:

41
Kidney, Liver, Breast, Lung

Publications for Dense Deposit Disease

Articles related to Dense Deposit Disease:

(show top 50) (show all 109)
# Title Authors Year
1
Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report. ( 29724182 )
2018
2
C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy. ( 29310824 )
2018
3
Dense Deposit Disease Involving C3 and C4d Deposits. ( 29515303 )
2018
4
Cloudy Cornea with Arcus Juvenilis in a Case of Dense Deposit Disease. ( 29950499 )
2018
5
Treatment with bortezomib in dense deposit disease associated with monoclonal gammopathy of undetermined significance. ( 29363742 )
2018
6
Retinal Basal Laminar Deposits in Complement fH/fP Mouse Model of Dense Deposit Disease. ( 30025090 )
2018
7
A long history of dense deposit disease. ( 30255792 )
2018
8
Dense deposit disease in a child with febrile sore throat. ( 28748900 )
2017
9
Dense deposit disease associated with multiple myelomaa8c. ( 29208205 )
2017
10
Discontinuation of dialysis with eculizumab therapy in a pediatric patient with dense deposit disease. ( 26759144 )
2016
11
Proliferative C4 Dense Deposit Disease, Acute ThromboticA Microangiopathy, a Monoclonal Gammopathy, andA Acute Kidney Failure. ( 26704376 )
2016
12
Dense Deposit Disease Mimicking a Renal Small Vessel Vasculitis. ( 26361799 )
2015
13
Eculizumab in Pediatric Dense Deposit Disease. ( 26316621 )
2015
14
Overlap of ultrastructural findings in C3 glomerulonephritis and dense deposit disease. ( 26649668 )
2015
15
AJKD Atlas of Renal Pathology: Dense Deposit Disease. ( 26300205 )
2015
16
C4 dense-deposit disease. ( 24552345 )
2014
17
Streptococcal infection as possible trigger for dense deposit disease (C3 glomerulopathy). ( 24384791 )
2014
18
Heterogeneous histologic and clinical evolution in 3 cases of dense deposit disease with long-term follow-up. ( 25260719 )
2014
19
Eculizumab in dense-deposit disease after renal transplantation. ( 24908321 )
2014
20
C3 glomerulopathy: the genetic and clinical findings in dense deposit disease and C3 glomerulonephritis. ( 24799308 )
2014
21
Eculizumab therapy in a patient with dense-deposit disease associated with partial lipodystropy. ( 24464478 )
2014
22
Blockade of alternative complement pathway in dense deposit disease. ( 24672732 )
2014
23
Dense deposit disease in an elderly patient: report of a case. ( 24998957 )
2014
24
Complement factor H-related hybrid protein deregulates complement in dense deposit disease. ( 24334459 )
2014
25
Dense deposit disease: a 29-years electron microscopy experience. ( 24053741 )
2013
26
Alternative pathway dysfunction in kidney disease: a case report and review of dense deposit disease and C3 glomerulopathy. ( 23391537 )
2013
27
Dense Deposit Disease: A Rare Cause of Steroid Resistant Nephrotic Syndrome. ( 23783769 )
2013
28
Dense deposit disease and C3 glomerulopathy. ( 24161036 )
2013
29
Childhood-onset dense deposit disease: a rare cause of proteinuria. ( 24338037 )
2013
30
Eculizumab for dense deposit disease and C3 glomerulonephritis. ( 22403278 )
2012
31
Dense deposit disease in Korean children: a multicenter clinicopathologic study. ( 23091320 )
2012
32
Pathology after eculizumab in dense deposit disease and C3 GN. ( 22677550 )
2012
33
Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. ( 22456601 )
2012
34
Clinical and pathological features of dense deposit disease in Chinese patients. ( 22874109 )
2012
35
Eculizumab in a patient with dense-deposit disease. ( 22435382 )
2012
36
Clinical features and outcomes of 98 children and adults with dense deposit disease. ( 22105967 )
2012
37
Screening for anti-factor B autoantibody in a patient with acute renal injury due to dense deposit disease. ( 22185975 )
2012
38
Causes of alternative pathway dysregulation in dense deposit disease. ( 22223606 )
2012
39
Recurrent dense deposit disease after renal transplantation: an emerging role for complementary therapies. ( 22233157 )
2012
40
Eculizumab for the treatment of dense-deposit disease. ( 22435383 )
2012
41
Anti-factor H antibody affecting factor H cofactor activity in a patient with dense deposit disease. ( 29497514 )
2012
42
Experimental models of membranoproliferative glomerulonephritis, including dense deposit disease. ( 21252520 )
2011
43
Acute renal failure in dense deposit disease: complete recovery after combination therapy with immunosuppressant and plasma exchange. ( 21269585 )
2011
44
Poststreptococcal acute glomerulonephritis and dense deposit disease after pediatric liver transplantation. ( 21383603 )
2011
45
Dense deposit disease. ( 21601923 )
2011
46
Allelic variants of complement genes associated with dense deposit disease. ( 21784901 )
2011
47
A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency. ( 20221776 )
2010
48
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. ( 20852386 )
2010
49
Anti-factor B autoantibody in dense deposit disease. ( 20193965 )
2010
50
Dense deposit disease associated with monoclonal gammopathy of undetermined significance. ( 20832153 )
2010

Variations for Dense Deposit Disease

ClinVar genetic disease variations for Dense Deposit Disease:

6 (show top 50) (show all 184)
# Gene Variation Type Significance SNP ID Assembly Location
1 CFH NM_000186.3(CFH): c.184G> A (p.Val62Ile) single nucleotide variant Benign rs800292 GRCh37 Chromosome 1, 196642233: 196642233
2 CFH NM_000186.3(CFH): c.184G> A (p.Val62Ile) single nucleotide variant Benign rs800292 GRCh38 Chromosome 1, 196673103: 196673103
3 CFHR5 NM_030787.3(CFHR5): c.622T> C (p.Cys208Arg) single nucleotide variant Uncertain significance rs41299613 GRCh37 Chromosome 1, 196964861: 196964861
4 CFHR5 NM_030787.3(CFHR5): c.622T> C (p.Cys208Arg) single nucleotide variant Uncertain significance rs41299613 GRCh38 Chromosome 1, 196995731: 196995731
5 CFH NM_000186.3(CFH): c.3176T> C (p.Ile1059Thr) single nucleotide variant Benign/Likely benign rs35343172 GRCh37 Chromosome 1, 196712624: 196712624
6 CFH NM_000186.3(CFH): c.3176T> C (p.Ile1059Thr) single nucleotide variant Benign/Likely benign rs35343172 GRCh38 Chromosome 1, 196743494: 196743494
7 CFH NM_000186.3(CFH): c.-195T> C single nucleotide variant Benign rs35836460 GRCh38 Chromosome 1, 196651923: 196651923
8 CFH NM_000186.3(CFH): c.-195T> C single nucleotide variant Benign rs35836460 GRCh37 Chromosome 1, 196621053: 196621053
9 CFH NM_000186.3(CFH): c.-61A> G single nucleotide variant Uncertain significance rs886045741 GRCh38 Chromosome 1, 196652057: 196652057
10 CFH NM_000186.3(CFH): c.-61A> G single nucleotide variant Uncertain significance rs886045741 GRCh37 Chromosome 1, 196621187: 196621187
11 CFH NM_000186.3(CFH): c.428-3C> T single nucleotide variant Uncertain significance rs886045744 GRCh38 Chromosome 1, 196677473: 196677473
12 CFH NM_000186.3(CFH): c.428-3C> T single nucleotide variant Uncertain significance rs886045744 GRCh37 Chromosome 1, 196646603: 196646603
13 CFH NM_000186.3(CFH): c.1949G> T (p.Gly650Val) single nucleotide variant Likely benign rs143237092 GRCh37 Chromosome 1, 196695675: 196695675
14 CFH NM_000186.3(CFH): c.1949G> T (p.Gly650Val) single nucleotide variant Likely benign rs143237092 GRCh38 Chromosome 1, 196726545: 196726545
15 CFH NM_000186.3(CFH): c.2016A> G (p.Gln672=) single nucleotide variant Benign rs3753396 GRCh37 Chromosome 1, 196695742: 196695742
16 CFH NM_000186.3(CFH): c.2016A> G (p.Gln672=) single nucleotide variant Benign rs3753396 GRCh38 Chromosome 1, 196726612: 196726612
17 CFH NM_000186.3(CFH): c.2236+8T> A single nucleotide variant Likely benign rs7537967 GRCh37 Chromosome 1, 196696078: 196696078
18 CFH NM_000186.3(CFH): c.2236+8T> A single nucleotide variant Likely benign rs7537967 GRCh38 Chromosome 1, 196726948: 196726948
19 CFH NM_000186.3(CFH): c.2808G> T (p.Glu936Asp) single nucleotide variant Benign rs1065489 GRCh37 Chromosome 1, 196709774: 196709774
20 CFH NM_000186.3(CFH): c.2808G> T (p.Glu936Asp) single nucleotide variant Benign rs1065489 GRCh38 Chromosome 1, 196740644: 196740644
21 CFH NM_000186.3(CFH): c.-175T> C single nucleotide variant Uncertain significance rs762143457 GRCh38 Chromosome 1, 196651943: 196651943
22 CFH NM_000186.3(CFH): c.-175T> C single nucleotide variant Uncertain significance rs762143457 GRCh37 Chromosome 1, 196621073: 196621073
23 CFH NM_000186.3(CFH): c.3050C> T (p.Thr1017Ile) single nucleotide variant Likely benign rs34362004 GRCh37 Chromosome 1, 196711098: 196711098
24 CFH NM_000186.3(CFH): c.3050C> T (p.Thr1017Ile) single nucleotide variant Likely benign rs34362004 GRCh38 Chromosome 1, 196741968: 196741968
25 CFH NM_000186.3(CFH): c.3133+8G> T single nucleotide variant Likely benign rs142718541 GRCh38 Chromosome 1, 196742059: 196742059
26 CFH NM_000186.3(CFH): c.3133+8G> T single nucleotide variant Likely benign rs142718541 GRCh37 Chromosome 1, 196711189: 196711189
27 CFH NM_000186.3(CFH): c.-79A> G single nucleotide variant Likely benign rs35906110 GRCh38 Chromosome 1, 196652039: 196652039
28 CFH NM_000186.3(CFH): c.-79A> G single nucleotide variant Likely benign rs35906110 GRCh37 Chromosome 1, 196621169: 196621169
29 CFH NM_000186.3(CFH): c.-36G> C single nucleotide variant Likely benign rs140356702 GRCh38 Chromosome 1, 196652082: 196652082
30 CFH NM_000186.3(CFH): c.-36G> C single nucleotide variant Likely benign rs140356702 GRCh37 Chromosome 1, 196621212: 196621212
31 CFH NM_000186.3(CFH): c.275C> T (p.Pro92Leu) single nucleotide variant Uncertain significance rs886045743 GRCh38 Chromosome 1, 196673887: 196673887
32 CFH NM_000186.3(CFH): c.275C> T (p.Pro92Leu) single nucleotide variant Uncertain significance rs886045743 GRCh37 Chromosome 1, 196643017: 196643017
33 CFH NM_000186.3(CFH): c.285T> C (p.Thr95=) single nucleotide variant Uncertain significance rs148182625 GRCh38 Chromosome 1, 196673897: 196673897
34 CFH NM_000186.3(CFH): c.285T> C (p.Thr95=) single nucleotide variant Uncertain significance rs148182625 GRCh37 Chromosome 1, 196643027: 196643027
35 CFH NM_000186.3(CFH): c.1160-15T> C single nucleotide variant Benign rs34815383 GRCh38 Chromosome 1, 196690048: 196690048
36 CFH NM_000186.3(CFH): c.1160-15T> C single nucleotide variant Benign rs34815383 GRCh37 Chromosome 1, 196659178: 196659178
37 CFH NM_000186.3(CFH): c.3207T> C (p.Ser1069=) single nucleotide variant Likely benign rs62641697 GRCh38 Chromosome 1, 196743525: 196743525
38 CFH NM_000186.3(CFH): c.3207T> C (p.Ser1069=) single nucleotide variant Likely benign rs62641697 GRCh37 Chromosome 1, 196712655: 196712655
39 CFH NM_000186.3(CFH): c.1204C> T (p.His402Tyr) single nucleotide variant Benign rs1061170 GRCh38 Chromosome 1, 196690107: 196690107
40 CFH NM_000186.3(CFH): c.1204C> T (p.His402Tyr) single nucleotide variant Benign rs1061170 GRCh37 Chromosome 1, 196659237: 196659237
41 CFH NM_000186.3(CFH): c.1428A> G (p.Gln476=) single nucleotide variant Likely benign rs34399588 GRCh38 Chromosome 1, 196713826: 196713826
42 CFH NM_000186.3(CFH): c.1428A> G (p.Gln476=) single nucleotide variant Likely benign rs34399588 GRCh37 Chromosome 1, 196682956: 196682956
43 CFH NM_000186.3(CFH): c.3310+12T> C single nucleotide variant Uncertain significance rs757045842 GRCh38 Chromosome 1, 196743640: 196743640
44 CFH NM_000186.3(CFH): c.3310+12T> C single nucleotide variant Uncertain significance rs757045842 GRCh37 Chromosome 1, 196712770: 196712770
45 CFH NM_000186.3(CFH): c.3427C> G (p.Gln1143Glu) single nucleotide variant Benign rs15809 GRCh38 Chromosome 1, 196745933: 196745933
46 CFH NM_000186.3(CFH): c.3427C> G (p.Gln1143Glu) single nucleotide variant Benign rs15809 GRCh37 Chromosome 1, 196715063: 196715063
47 CFH NM_000186.3(CFH): c.1548T> A (p.Asn516Lys) single nucleotide variant Likely benign rs147403664 GRCh38 Chromosome 1, 196715621: 196715621
48 CFH NM_000186.3(CFH): c.1548T> A (p.Asn516Lys) single nucleotide variant Likely benign rs147403664 GRCh37 Chromosome 1, 196684751: 196684751
49 CFH NM_000186.3(CFH): c.2542G> A (p.Gly848Arg) single nucleotide variant Uncertain significance rs886045746 GRCh37 Chromosome 1, 196706082: 196706082
50 CFH NM_000186.3(CFH): c.2542G> A (p.Gly848Arg) single nucleotide variant Uncertain significance rs886045746 GRCh38 Chromosome 1, 196736952: 196736952

Expression for Dense Deposit Disease

Search GEO for disease gene expression data for Dense Deposit Disease.

Pathways for Dense Deposit Disease

GO Terms for Dense Deposit Disease

Cellular components related to Dense Deposit Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.33 C3 CFHR2 CFHR5
2 blood microparticle GO:0072562 9.13 C3 CFB CFH
3 extracellular region GO:0005576 9.1 C3 C5 CFB CFH CFHR2 CFHR5

Biological processes related to Dense Deposit Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.62 C3 C5 CFB CFH
2 immune system process GO:0002376 9.61 C3 C5 CFB
3 complement activation GO:0006956 9.46 C3 C5 CFB CFH
4 regulation of complement activation GO:0030449 9.43 C3 C5 CFB CFH CFHR2 CFHR5
5 negative regulation of protein binding GO:0032091 9.4 CFHR2 CFHR5
6 positive regulation of vascular endothelial growth factor production GO:0010575 9.37 C3 C5
7 positive regulation of cytolysis GO:0045919 9.26 CFHR2 CFHR5
8 complement activation, alternative pathway GO:0006957 9.02 C3 C5 CFB CFH CFHR5

Molecular functions related to Dense Deposit Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C3 C5

Sources for Dense Deposit Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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